@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : MYO3B_HUMAN: (2015-10-15 )
MKHLYGLFHYNPMMLGLESLPDPTDTWEIIETIGKGTYGKVYKVTNKRDGSLAAVKILDPVSDMDEEIEAEYNILQFLPNHPNVVKFYGMFYKADHCVGGQLWLVLELCNGGSVTELVKGLLRCGQRLDEAMISYILYGALLGLQHLHNNRIIHRDVKGNNILLTTEGGVKLVDFGVSAQLTSTRLRRNTSVGTPFWMAPEVIACEQQYDSSYDARCDVWSLGITAIELGDGDPPLFDMHPVKTLFKIPRNPPPTLLHPEKWCEEFNHFISQCLIKDFERRPSVTHLLDHPFIKGVHGKVLFLQKQLAKVLQDQKHQNPVAKTRHERMHTRRPYHVEDAEKYCLEDDLVNLEVLDEDTIIHQLQKRYADLLIYTYVGDILIALNPFQNLSIYSPQFSRLYHGVKRASNPPHIFASADAAYQCMVTLSKDQCIVISGESGSGKTESAHLIVQHLTFLGKANNQTLREKILQVNSLVEAFGNSCTAINDNSSRFGKYLEMMFTPTGVVMGARISEYLLEKSRVIKQAAREKNFHIFYYIYAGLHHQKKLSDFRLPEEKPPRYIADETGRVMHDITSKESYRRQFEAIQHCFRIIGFTDKEVHSVYRILAGILNIGNIEFAAISSQHQTDKSEVPNAEALQNAASVLCISPEELQEALTSHCVVTRGETIIRANTVDRAADVRDAMSKALYGRLFSWIVNRINTLLQPDENICSAGGGMNVGILDIFGFENFQRNSFEQLCINIANEQIQYYFNQHVFALEQMEYQNEGIDAVPVEYEDNRPLLDMFLQKPLGLLALLDEESRFPQATDQTLVDKFEDNLRCKYFWRPKGVELCFGIQHYAGKVLYDASGVLEKNRDTLPADVVVVLRTSENKLLQQLFSIPLTKTGNLAQTRARITVASSSLPPHFSAGKAKVDTLEVIRHPEETTNMKRQTVASYFRYSLMDLLSKMVVGQPHFVRCIKPNDDREALQFSRERVLAQLRSTGILETVSIRRQGYSHRILFEEFVKRYYYLAFTAHQTPLASKESCVAILEKSRLDHWVLGKTKVFLKYYHVEQLNLLLREVIGRVVVLQAYTKGWLGARRYKRVREKREKGAIAIQSAWRGYDARRKFKKISNRRNESAAHNQAGDTSNQSSGPHSPVAAGTRGSAEVQDCSEPGDHKVLRGSVHRRSHSQAESNNGRTQTSSNSPAVTEKNGHSQAQSSPKGCDIFAGHANKHSVSGTDLLSSRICHPAPDQQGLSLWGAPQKPGSENGLAQKHRTPRRRCQQPKMLSSPEDTMYYNQLNGTLEYQGSKRKPRKLGQIKVLDGEDEYYKSLSPVDCIPEENNSAHPSFFSSSSKGDSFAQH
Atome Classification :
(52 SA)
.........10........20........30........40........50........60........70........80........90........100.......110.......120.......130.......140.......150.......160.......170.......180.......190.......200.......210.......220.......230.......240.......250.......260.......270.......280.......290.......300.......310.......320.......330.......340.......350.......360.......-370.......380.......-390.......400.......410.......420.......430.......440.......450.-......---460----.......470.......480.......490.......500.......510.......520.......530.......540-------.......550.......560.-....-..570-........580--------........--.590.......600.......610.......620.......630........640...-....650.......660-----.......670.......680.......690.......700.......710.......720.......730.......740.......750.......760.......770...-....780...-....790.......800.......810---......--..820...--------...-----...830---------........840.......850.......860.......-870.......880.......890.......900.......910.......920.......930.......940.......950.......960.......970.......980.......990.......1000...--...1010-......1020....-....1030--.--.....1040......1050......1060...-....1070......1080......1090..---...---.1100......1110......1120......1130......1140......1150......1160......1170......1180......1190......1200......1210......1220......1230......1240......1250......1260......1270......1280......1290......1300......1310......1320......1330......1340
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MK
H
L
Y
G
L
FHYN
P
M
M
L
G
L
E
SLPDPT
D
T
W
E
I
I
E
T
IGKGTYG
K
V
Y
K
V
TNKRDG
S
L
A
A
V
K
I
LDPVS
D
M
D
E
E
I
E
A
E
Y
N
I
L
Q
FLPNHP
N
V
V
K
F
Y
G
M
F
Y
KADHCVG
G
Q
L
W
L
V
L
E
LCNGG
S
V
T
E
L
V
K
G
L
L
R
C
G
Q
R
L
D
E
A
M
I
S
Y
I
L
Y
G
A
L
L
G
L
Q
H
L
HNN
R
I
I
H
R
DVKG
N
N
I
L
L
TTEG
G
V
K
L
V
D
FGVSA
Q
L
T
S
T
R
LRRNTSVGTPFWMA
P
E
V
I
A
C
E
Q
Q
YDSSYDARC
D
V
W
S
L
G
I
T
A
I
ELGDGDPPLFDMH
P
V
K
T
L
F
KIPRNPPPTLL
H
P
E
K
W
C
E
E
F
N
H
F
I
S
Q
C
L
I
K
D
F
E
RRPS
V
T
H
L
LDHPFIKGVHGK
V
L
F
L
Q
K
Q
L
A
K
V
L
Q
DQKHQN
P
V
A
K
T
R
H
E
R
MHTRRPY
H
V
E
D
A
E
K
Y
CLEDDLV
N
L
E
VLD
E
D
T
I
I
H
Q
L
Q
K
R
Y
A
D
-
L
L
I
Y
TYVG
D
I
L
I
ALNPFQNL-SIY
S
P
Q
F
S
R
L
Y
H
G
V
K
RASNP
P
H
I
F
ASAD
A
A
Y
Q
C
M
V
T
LSKD
Q
C
I
V
I
SGESGSGK
T
E
S
A
H
L
I
V
Q
H
L
-
T
F
LGKA---N
N
Q
----
T
L
R
E
K
I
L
Q
V
N
S
L
V
E
A
FGNS
C
T
AIND
N
S
S
R
F
G
K
Y
L
E
M
MFTPT
G
V
V
M
G
A
R
I
S
E
Y
L
L
E
K
S
R
V
I
K
Q
A
A
REKN
F
H
I
F
Y
Y
I
YAGL
H
-------
H
Q
K
K
L
S
DFRLPEEKPPRYIAD-ET
G
R
-
V
M
H
D
--ITS
K
E
S
Y
R
R
----------
Q
F
E
A
I
Q
H
C
--
F
R
IIGFT
D
K
E
V
H
S
V
Y
R
I
L
A
G
I
L
NIG
N
I
E
F
A
A
ISSQHQT
D
K
SEV-P
N
A
E
A
L
Q
N
A
A
S
V
L
C
-I
S
P
E
E
L
Q
E
A
L
T
S
H
C
V
VT-----RG
E
T
I
I
R
ANTVD
R
A
A
D
V
R
D
A
M
S
K
A
L
Y
G
R
L
F
S
W
I
V
N
R
I
N
T
LLQPD
E
N
I
CSAGG
G
M
N
V
G
I
L
D
I
FGFENFQRN
S
F
E
Q
L
C
I
N
I
A
N
E
Q
I
Q
Y
Y
F
N
Q
H
V
F
A
L
E
Q
M
E
YQNEGIDAVPVEYE-DNR
P
L
L
D
M
F
L
-QKP
L
G
L
L
A
LLDEESRFPQAT
D
Q
T
L
V
D
----
K
FEDN
L
--
R
C
K
--
Y
F
W--------RPK-----G
V
E
L
C
----------
F
G
I
Q
H
YA
G
K
V
L
YDASGVLEKNRDTLPA
D
V
V
V
V
L
RTS
E
N
-
K
L
L
Q
Q
L
FSIPLTKTG
N
L
A
Q
T
R
A
R
I
T
V
ASSSLPPHFSAGKAKV
D
T
L
E
V
IRH
P
E
E
TT
N
M
K
R
Q
T
V
A
S
Y
F
R
Y
S
L
M
D
L
L
S
K
M
VVGQP
H
F
V
R
C
IKPND
D
R
E
A
L
Q
F
S
R
E
R
V
L
A
Q
L
R
STGI
L
E
T
V
S
I
R
RQGYSH
R
I
L
F
E
E
F
V
K
R
Y
--
Y
Y
L
A
F
TA-HQTPLA
S
--
K
E
S
C
V
-
A
I
L
E
K
SRL--D--
H
W
VLG
K
T
K
V
F
L
K
Y
Y
H
V
E
Q
L
N
L
L
L
R
E
V
I
-
G
R
V
V
-
V
L
Q
A
Y
T
K
G
W
L
G
A
R
R
Y
K
R
V
R
E
K
R
EK
G
A
I
A
I
Q
---
S
A
W---R
G
Y
D
A
R
R
K
F
K
K
I
SNRRNESAAHNQAGDTSNQSSGPHSPVAAGTRGSAEVQDCSEPGD
H
K
V
L
R
G
S
VHRRSHSQAESNNGRTQTSSNSPAVTEKNGHSQAQSSPKG
C
D
I
F
AGHANKHSVS
G
T
D
L
L
S
SRICHPAPDQQGLSLWGAPQKPGSENG
L
A
Q
KHR
T
P
R
R
RCQQPKMLSSPED
T
M
Y
Y
NQLN
G
T
L
E
YQGSKRKPRKL
G
Q
I
K
VLDG
E
D
E
Y
Y
KSLSPVDCIPEENNSAHPSFFSSSSKGDSFAQH
44
PsiBlast_CBE
85.22
35%
-101
- C2 -
1W7J
1
MYO5A_CHICK
A:
[71-791]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
N
D
L
T
A
L
S
Y
L
H
E
P
A
V
L
H
N
L
K
V
R
F
I
D
S
K
L
I
Y
T
Y
C
G
I
V
L
V
A
I
N
P
Y
E
Q
L
-
P
I
Y
G
E
D
I
I
N
A
Y
S
G
Q
N
M
G
D
M
D
P
H
I
F
A
V
A
E
E
A
Y
K
Q
M
A
R
D
E
R
N
Q
S
I
I
V
S
G
E
S
G
A
G
K
T
V
S
A
K
Y
A
M
R
Y
F
A
T
V
S
G
S
A
---
S
E
A
----
N
V
E
E
K
V
L
A
S
N
P
I
M
E
S
I
G
N
A
K
T
T
R
N
D
N
S
S
R
F
G
K
Y
I
E
I
G
F
D
K
R
Y
R
I
I
G
A
N
M
R
T
Y
L
L
E
K
S
R
V
V
F
Q
A
E
E
E
R
N
Y
H
I
F
Y
Q
L
C
A
S
A
--------
A
L
P
E
F
K
T
L
R
L
G
N
A
N
Y
F
H
Y
T
K
Q
-
G
G
S
P
-
V
I
D
G
--
I
---
D
D
A
K
E
----------
M
V
N
T
R
Q
A
C
---
T
L
L
G
I
S
D
S
Y
Q
M
G
I
F
R
I
L
A
G
I
L
H
L
G
N
V
E
F
A
S
R
D
S
----
D
S
C
A
I
P
P
K
H
D
P
L
T
I
F
C
D
L
M
G
-
V
D
Y
E
E
M
A
H
W
L
C
H
R
K
L
A
T
-----
A
T
E
T
Y
I
K
P
I
S
K
L
H
A
I
N
A
R
D
A
L
A
K
H
I
Y
A
N
L
F
N
W
I
V
D
H
V
N
K
A
L
H
-----
S
T
V
K
Q
H
S
F
I
G
V
L
D
I
Y
G
F
E
T
F
E
I
N
S
F
E
Q
F
C
I
N
Y
A
N
E
K
L
Q
Q
Q
F
N
M
H
V
F
K
L
E
Q
E
E
Y
M
K
E
Q
I
P
W
T
L
I
D
F
Y
-
D
N
Q
P
C
I
N
L
-
I
-
E
A
K
M
G
V
L
D
L
L
D
E
E
C
K
M
P
K
G
S
D
D
T
W
A
Q
----
K
L
Y
N
T
H
LN
K
C
A
--
L
F
E
--------
K
P
R
-----
L
S
N
K
A
----------
F
I
I
K
H
F
A
D
K
V
E
Y
Q
C
E
G
F
L
E
K
N
K
D
T
V
Y
E
E
Q
I
K
V
L
K
S
S
K
K
F
K
L
L
P
E
L
F
Q
---------------------------------------------------
K
T
V
G
H
Q
F
R
N
S
L
H
L
L
M
E
T
L
N
A
T
T
P
H
Y
V
R
C
I
K
P
N
D
F
K
F
P
F
T
F
D
E
K
R
A
V
Q
Q
L
R
A
C
G
V
L
E
T
I
R
I
S
A
A
G
F
P
S
R
W
T
Y
Q
E
F
F
S
R
Y
--
R
V
L
---
M
-
K
Q
K
D
V
L
S
D
R
K
Q
T
C
K
-
N
V
L
E
K
L
I
L
DK
D
--
K
Y
Q
F
G
K
T
K
I
F
F
R
A
G
Q
V
A
Y
L
E
K
I
R
A
D
K
L
R
A
A
C
I
-
R
I
Q
K
T
I
R
G
W
L
M
R
K
K
Y
M
R
M
R
R
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
9
PsiBlast_PDB
81.33
35%
-98
- C2 -
1MMD
1
MYS2_DICDI
A:
[89-747]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
D
M
S
E
L
S
Y
L
N
E
P
A
V
F
H
N
L
R
V
R
Y
N
Q
-
D
L
I
Y
T
Y
S
G
L
F
L
V
A
V
N
P
F
K
R
I
-
P
I
Y
T
Q
E
M
V
D
I
F
K
G
R
R
R
N
E
V
A
P
H
I
F
A
I
S
D
V
A
Y
R
S
M
L
D
D
R
Q
N
Q
S
L
L
I
T
G
E
S
G
A
G
K
T
E
N
T
K
K
V
I
Q
Y
L
-
A
S
V
A
G
R
---
N
Q
A
G---
V
L
E
Q
Q
I
L
Q
A
N
P
I
L
E
A
F
G
N
A
K
T
T
R
N
N
N
S
S
R
F
G
K
F
I
E
I
Q
F
N
N
A
G
F
I
S
G
A
S
I
Q
S
Y
L
L
E
K
S
R
V
V
F
Q
S
E
T
E
R
N
Y
H
I
F
Y
Q
L
L
A
G
A
T
-------
A
E
E
K
K
A
-
L
H
L
A
G
P
E
S
F
N
Y
L
-
N
-
Q
S
G
C
-
V
D
I
K
--
G
V
S
D
E
D
-------------
E
F
K
I
T
R
Q
A
--
M
D
I
V
G
F
S
Q
E
E
Q
M
S
I
F
K
I
I
A
G
I
L
H
L
G
N
I
K
F
E
K
G
A
G
E
G
A
V
L
K
D
K
T
-----
A
L
N
A
A
S
T
V
F
G
-
V
N
P
S
V
L
E
K
A
L
M
E
P
R
I
L
A
-----
G
R
D
L
V
A
Q
H
L
N
V
E
K
S
S
S
S
R
D
A
L
V
K
A
L
Y
G
R
L
F
L
W
L
V
K
K
I
N
N
V
L
------
C
S
E
R
A
A
Y
F
I
G
V
L
D
I
S
G
F
E
I
F
K
V
N
S
F
E
Q
L
C
I
N
Y
T
N
E
K
L
Q
Q
F
F
N
H
H
M
F
K
V
E
Q
E
E
Y
L
K
E
K
I
N
-------L
D
S
Q
A
T
I
D
L
I
D
G
R
Q
P
P
G
I
L
A
L
L
D
E
Q
S
V
F
P
N
A
T
D
N
T
L
I
T
----
K
L
H
S
H
F
--
S
K
K
NA
K
Y
E
--------
E
P
R
-----
F
S
K
T
E
----------
F
G
V
T
H
Y
A
G
Q
V
M
Y
E
I
Q
D
W
L
E
K
N
K
D
P
L
Q
Q
D
L
E
L
C
F
K
D
S
S
D
-
N
V
V
T
K
L
F
N
D
P
-----
N
I
A
-----------------
S
R
A
-----
F
I
---------------
T
V
A
A
Q
Y
K
E
Q
L
A
S
L
M
A
T
L
E
T
T
N
P
H
F
V
R
C
I
I
P
N
N
K
Q
L
P
A
K
L
E
D
K
V
V
L
D
Q
L
R
C
N
G
V
L
E
G
I
R
I
T
R
K
G
F
P
N
R
I
I
Y
A
D
F
V
K
R
Y
--
Y
L
L
A
P
N
V
-
P
R
D
A
E
D
S
--
Q
K
A
T
D
-
A
V
L
K
H
L
N
I
--
D
PE
Q
Y
R
F
G
I
T
K
I
F
F
R
A
G
Q
L
A
R
I
E
E
A
R
E
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
33
PsiBlast_CBE
81.14
35%
-98
- C2 -
1D0X
1
MYS2_DICDI
A:
[89-747]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
D
M
S
E
L
S
Y
L
N
E
P
A
V
F
H
N
L
R
V
R
Y
N
Q
-
D
L
I
Y
T
Y
S
G
L
F
L
V
A
V
N
P
F
K
R
I
-
P
I
Y
T
Q
E
M
V
D
I
F
K
G
R
R
R
N
E
V
A
P
H
I
F
A
I
S
D
V
A
Y
R
S
M
L
D
D
R
Q
N
Q
S
L
L
I
T
G
E
S
G
A
G
K
T
E
N
T
K
K
V
I
Q
Y
L
-
A
S
V
A
G
R
---
N
--G---
V
L
E
Q
Q
I
L
Q
A
N
P
I
L
E
A
F
G
N
A
K
T
T
R
N
N
N
S
S
R
F
G
K
F
I
E
I
Q
F
N
N
A
G
F
I
S
G
A
S
I
Q
S
Y
L
L
E
K
S
R
V
V
F
Q
S
E
T
E
R
N
Y
H
I
F
Y
Q
L
L
A
G
A
T
-------
A
E
E
K
K
A
-
L
H
L
A
G
P
E
S
F
N
Y
L
-
N
-
Q
S
G
C
-
V
--
D
--
I
K
G
V
-
S
D
S
E
----------
E
F
K
I
T
R
Q
A
--
M
D
I
V
G
F
S
Q
E
E
Q
M
S
I
F
K
I
I
A
G
I
L
H
L
G
N
I
K
F
E
K
G
A
G
E
G
A
V
L
K
D
K
T
-----
A
L
N
A
A
S
T
V
F
G
-
V
N
P
S
V
L
E
K
A
L
M
E
P
R
I
L
A
-----
G
R
D
L
V
A
Q
H
L
N
V
E
K
S
S
S
S
R
D
A
L
V
K
A
L
Y
G
R
L
F
L
W
L
V
K
K
I
N
N
V
L
------
C
Q
E
R
K
A
Y
F
I
G
V
L
D
I
S
G
F
E
I
F
K
V
N
S
F
E
Q
L
C
I
N
Y
T
N
E
K
L
Q
Q
F
F
N
H
H
M
F
K
L
E
Q
E
E
Y
L
K
E
K
I
N
--------
D
S
Q
A
T
I
D
L
I
D
G
R
Q
P
P
G
I
L
A
L
L
D
E
Q
S
V
F
P
N
A
T
D
N
T
L
I
T
----
K
L
H
S
H
F
--
S
K
K
NA
K
Y
E
--------
E
P
R
-----
F
S
K
T
E
----------
F
G
V
T
H
Y
A
G
Q
V
M
Y
E
I
Q
D
W
L
E
K
N
K
D
P
L
Q
Q
D
L
E
L
C
F
K
D
S
S
D
-
N
V
V
T
K
L
F
N
D
P
-----
N
I
A
-----------------
S
R
A
-----
F
I
---------------
T
V
A
A
Q
Y
K
E
Q
L
A
S
L
M
A
T
L
E
T
T
N
P
H
F
V
R
C
I
I
P
N
N
K
Q
L
P
A
K
L
E
D
K
V
V
L
D
Q
L
R
C
N
G
V
L
E
G
I
R
I
T
R
K
G
F
P
N
R
I
I
Y
A
D
F
V
K
R
Y
--
Y
L
L
A
P
N
V
-
P
R
D
A
E
D
S
--
Q
K
A
T
D
-
A
V
L
K
H
L
N
I
--
D
PE
Q
Y
R
F
G
I
T
K
I
F
F
R
A
G
Q
L
A
R
I
E
E
A
R
E
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
24
PsiBlast_CBE
81.02
35%
-99
- C2 -
1JX2
2
MYS2_DICDI
A:
[100-758]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
D
M
S
E
L
S
Y
L
N
E
P
A
V
F
H
N
L
R
V
R
Y
N
Q
-
D
L
I
Y
T
Y
S
G
L
F
L
V
A
V
N
P
F
K
R
I
-
P
I
Y
T
Q
E
M
V
D
I
F
K
G
R
R
R
N
E
V
A
P
H
I
F
A
I
S
D
V
A
Y
R
S
M
L
D
D
R
Q
N
Q
S
L
L
I
T
G
E
S
G
A
G
K
T
E
N
T
K
K
V
I
Q
Y
L
-
A
S
V
A
G
-------SG--
V
L
E
Q
Q
I
L
Q
A
N
P
I
L
E
A
F
G
N
A
K
T
T
R
N
N
N
S
S
R
F
G
K
F
I
E
I
Q
F
N
S
A
G
F
I
S
G
A
S
I
Q
S
Y
L
L
E
K
S
R
V
V
F
Q
S
E
T
E
R
N
Y
H
I
F
Y
Q
L
L
A
G
A
T
-------
A
E
E
K
K
A
-
L
H
L
A
G
P
E
S
F
N
Y
L
-
N
-
Q
S
G
C
-
V
--
D
--
I
K
G
V
-
S
D
S
E
----------
E
F
K
I
T
R
Q
A
--
M
D
I
V
G
F
S
Q
E
E
Q
M
S
I
F
K
I
I
A
G
I
L
H
L
G
N
I
K
F
E
K
G
A
G
E
G
A
V
L
K
D
K
T
-----
A
L
N
A
A
S
T
V
F
G
-
V
N
P
S
V
L
E
K
A
L
M
E
P
R
I
L
A
-----
G
R
D
L
V
A
Q
H
L
N
V
E
K
S
S
S
S
R
D
A
L
V
K
A
L
Y
G
R
L
F
L
W
L
V
K
K
I
N
N
V
L
------
C
Q
E
R
K
A
Y
F
I
G
V
L
D
I
S
G
F
E
I
F
K
V
N
S
F
E
Q
L
C
I
N
Y
T
N
E
K
L
Q
Q
F
F
N
H
H
M
F
K
L
E
Q
E
E
Y
L
K
E
K
I
N
W
T
F
I
D
F
G
L
D
S
Q
A
T
I
D
L
I
D
G
R
Q
P
P
G
I
L
A
L
L
D
E
Q
S
V
F
P
N
A
T
D
N
T
L
I
T
----
K
L
H
S
H
F
--
S
K
K
NA
K
Y
E
--------
E
P
R
-----
F
S
K
T
E
----------
F
G
V
T
H
Y
A
G
Q
V
M
Y
E
I
Q
D
W
L
E
K
N
K
D
P
L
Q
Q
D
L
E
L
C
F
K
D
S
S
D
-
N
V
V
T
K
L
F
N
D
P
-----
N
I
A
-----------------
S
R
A
K
K
G
A
N
F
I
---------------
T
V
A
A
Q
Y
K
E
Q
L
A
S
L
M
A
T
L
E
T
T
N
P
H
F
V
R
C
I
I
P
N
N
K
Q
L
P
A
K
L
E
D
K
V
V
L
D
Q
L
R
C
N
G
V
L
E
G
I
R
I
T
R
K
G
F
P
N
R
I
I
Y
A
D
F
V
K
R
Y
--
Y
L
L
A
P
N
V
-
P
R
D
A
E
D
S
--
Q
K
A
T
D
-
A
V
L
K
H
L
N
I
--
D
PE
Q
Y
R
F
G
I
T
K
I
F
F
R
A
G
Q
L
A
R
I
E
E
A
R
E
Q
R
I
-
S
E
I
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
60
PsiBlast_CBE
80.93
33%
-97
- C2 -
1S5G
1
MYS_ARGIR
A:
[86-825]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
D
M
A
N
M
T
Y
L
N
E
A
S
V
L
Y
N
L
R
S
R
Y
T
S
-
G
L
I
Y
T
Y
S
G
L
F
C
I
A
V
N
P
Y
R
R
L
-
P
I
Y
T
D
S
V
I
A
K
Y
R
G
K
R
K
T
E
I
P
P
H
L
F
S
V
A
D
N
A
Y
Q
N
M
V
T
D
R
E
N
Q
S
C
L
I
T
G
E
S
G
A
G
K
T
E
N
T
K
K
V
I
M
Y
L
-
A
K
V
A
C
A
---
V
--EG--
S
L
E
D
Q
I
I
Q
A
N
P
V
L
E
A
Y
G
N
A
K
T
T
R
N
N
N
S
S
R
F
G
K
F
I
R
I
H
F
G
P
T
G
K
I
A
G
A
D
I
E
T
Y
L
L
E
K
S
R
V
T
Y
Q
Q
S
A
E
R
N
Y
H
I
F
Y
Q
I
C
S
--
N
-------
A
I
P
E
L
N
D
V
M
L
V
T
P
D
S
G
L
Y
S
F
I
-
N
Q
G
C
-
L
T
V
D
N-
I
D
D
V
E
--------------
E
F
K
L
C
D
E
A
--
F
D
I
L
G
F
T
K
E
E
K
Q
S
M
F
K
C
T
A
S
I
L
H
M
G
E
M
K
F
K
Q
R
P
R
E
E
Q
A
E
S
D
G
T
-
A
E
A
E
K
V
----
A
F
L
C
G
I
N
A
G
D
L
L
K
A
L
L
K
P
K
V
K
V
-----
G
T
E
M
V
T
K
G
Q
N
M
N
Q
V
V
N
S
V
G
A
L
A
K
S
L
Y
D
R
M
F
N
W
L
V
R
R
V
N
K
T
L
D
-----
T
K
A
K
R
N
Y
Y
I
G
V
L
D
I
A
G
F
E
I
F
D
F
N
S
F
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Q
L
C
I
N
Y
T
N
E
R
L
Q
Q
F
F
N
H
H
M
F
I
L
E
Q
E
E
Y
K
K
E
G
I
A
W
E
F
I
D
F
G
-
M
D
L
Q
M
C
I
D
L
I
-
E
K
P
M
G
I
L
S
I
L
E
E
E
C
M
F
P
K
A
D
D
K
S
F
Q
D
----
K
L
Y
Q
N
H
--
M
G
K
--
N
R
M
FT
K
P
G
K
P
T
R
P
N
-----
Q
G
P
A
H
----------
F
E
L
H
H
Y
A
G
N
V
P
Y
S
I
T
G
W
L
E
K
N
K
D
P
I
N
E
N
V
V
A
L
L
G
A
S
K
E
-
P
L
V
A
E
L
F
K
A
P
E
------------------------------------------------
Q
T
I
S
A
V
H
R
E
S
L
N
K
L
M
K
N
L
Y
S
T
H
P
H
F
V
R
C
I
I
P
N
E
L
K
Q
P
G
L
V
D
A
E
L
V
L
H
Q
L
Q
C
N
G
V
L
E
G
I
R
I
C
R
K
G
F
P
S
R
L
I
Y
S
E
F
K
Q
R
Y
--
S
I
L
A
P
N
A
I
P
Q
G
F
V
D
G
--
K
T
V
S
E
-
K
I
L
A
G
L
Q
M
--
D
PA
E
Y
R
L
G
T
T
K
V
F
F
K
A
G
V
L
G
N
L
E
E
M
R
D
E
R
L
-
S
K
I
I
S
M
F
Q
A
H
I
R
G
Y
L
I
R
K
A
Y
K
K
L
Q
D
Q
R
-
I
G
L
S
V
I
Q
---
R
N
I
---
R
K
W
L
V
L
R
N
W
Q
W
W
K
L
Y
S
K
V
K
P
L
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
36
PsiBlast_CBE
80.89
35%
-98
- C2 -
1W9K
8
MYS2_DICDI
A:
[89-747]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
D
M
S
E
L
S
Y
L
N
E
P
A
V
F
H
N
L
R
V
R
Y
N
Q
-
D
L
I
Y
T
Y
S
G
L
F
L
V
A
V
N
P
F
K
R
I
-
P
I
Y
T
Q
E
M
V
D
I
F
K
G
R
R
R
N
E
V
A
P
H
I
F
A
I
S
D
V
A
Y
R
S
M
L
D
D
R
Q
N
Q
S
L
L
I
T
G
E
S
G
A
G
K
T
E
N
T
K
K
V
I
Q
Y
L
-
A
S
V
A
G
R
------G---
V
L
E
Q
Q
I
L
Q
A
N
P
I
L
E
A
F
G
N
A
K
T
T
R
N
N
N
S
S
R
F
G
K
F
I
E
I
Q
F
N
S
A
G
F
I
S
G
A
S
I
Q
S
Y
L
L
E
K
S
R
V
V
F
Q
S
E
T
E
R
N
Y
H
I
F
Y
Q
L
L
A
G
A
T
-------
A
E
E
K
K
A
-
L
H
L
A
G
P
E
S
F
N
Y
L
-
N
-
Q
S
G
C
-
V
--
D
--
I
K
G
V
-
S
D
S
E
----------
E
F
K
I
T
R
Q
A
--
M
D
I
V
G
F
S
Q
E
E
Q
M
S
I
F
K
I
I
A
G
I
L
H
L
G
N
I
K
F
E
K
G
A
G
E
G
A
V
L
K
D
K
T
-----
A
L
N
A
A
S
T
V
F
G
-
V
N
P
S
V
L
E
K
A
L
M
E
P
R
I
L
A
-----
G
R
D
L
V
A
Q
H
L
N
V
E
K
S
S
S
S
R
D
A
L
V
K
A
L
Y
G
R
L
F
L
W
L
V
K
K
I
N
N
V
L
------
C
E
E
R
K
A
Y
F
I
G
V
L
D
I
E
G
F
E
I
F
K
V
N
S
F
E
Q
L
C
I
N
Y
T
N
E
K
L
Q
Q
F
F
N
H
H
M
F
K
L
E
Q
E
E
Y
L
K
E
K
I
N
W
T
F
I
D
F
G
L
D
S
Q
A
T
I
D
L
I
D
G
R
Q
P
P
G
I
L
A
L
L
D
E
Q
S
V
F
P
N
A
T
D
N
T
L
I
T
----
K
L
H
S
H
F
--
S
K
K
NA
K
Y
E
--------
E
P
R
-----
F
S
K
T
E
----------
F
G
V
T
H
Y
A
G
Q
V
M
Y
E
I
Q
D
W
L
E
K
N
K
D
P
L
Q
Q
D
L
E
L
C
F
K
D
S
S
D
-
N
V
V
T
K
L
F
N
D
P
-----
N
I
A
-----------------
S
R
A
K
----
F
I
---------------
T
V
A
A
Q
Y
K
E
Q
L
A
S
L
M
A
T
L
E
T
T
N
P
H
F
V
R
C
I
I
P
N
N
K
Q
L
P
A
K
L
E
D
K
V
V
L
D
Q
L
R
C
N
G
V
L
E
G
I
R
I
T
R
K
G
F
P
N
R
I
I
Y
A
D
F
V
K
----------------
E
D
S
--
Q
K
A
T
D
-
A
V
L
K
H
L
----
D
PE
Q
F
R
F
G
I
T
K
I
F
F
R
A
G
Q
L
A
R
I
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
31
PsiBlast_CBE
80.52
35%
-97
- C2 -
1D0Z
1
MYS2_DICDI
A:
[89-747]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
D
M
S
E
L
S
Y
L
N
E
P
A
V
F
H
N
L
R
V
R
Y
N
Q
-
D
L
I
Y
T
Y
S
G
L
F
L
V
A
V
N
P
F
K
R
I
-
P
I
Y
T
Q
E
M
V
D
I
F
K
G
R
R
R
N
E
V
A
P
H
I
F
A
I
S
D
V
A
Y
R
S
M
L
D
D
R
Q
N
Q
S
L
L
I
T
G
E
S
G
A
G
K
T
E
N
T
K
K
V
I
Q
Y
L
-
A
S
V
A
G
R
---
N
Q
-G---
V
L
E
Q
Q
I
L
Q
A
N
P
I
L
E
A
F
G
N
A
K
T
T
R
N
N
N
S
S
R
F
G
K
F
I
E
I
Q
F
N
N
A
G
F
I
S
G
A
S
I
Q
S
Y
L
L
E
K
S
R
V
V
F
Q
S
E
T
E
R
N
Y
H
I
F
Y
Q
L
L
A
G
A
T
-------
A
E
E
K
K
A
-
L
H
L
A
G
P
E
S
F
N
Y
L
-
N
-
Q
S
G
C
-
V
--
D
--
I
K
G
V
-
S
D
S
E
----------
E
F
K
I
T
R
Q
A
--
M
D
I
V
G
F
S
Q
E
E
Q
M
S
I
F
K
I
I
A
G
I
L
H
L
G
N
I
K
F
E
K
G
A
G
E
G
A
V
L
K
D
K
T
-----
A
L
N
A
A
S
T
V
F
G
-
V
N
P
S
V
L
E
K
A
L
M
E
P
R
I
L
A
-----
G
R
D
L
V
A
Q
H
L
N
V
E
K
S
S
S
S
R
D
A
L
V
K
A
L
Y
G
R
L
F
L
W
L
V
K
K
I
N
N
V
L
------
C
Q
E
R
K
A
Y
F
I
G
V
L
D
I
S
G
F
E
I
F
K
V
N
S
F
E
Q
L
C
I
N
Y
T
N
E
K
L
Q
Q
F
F
N
H
H
M
F
K
L
E
Q
E
E
Y
L
K
E
K
I
N
-------L
D
S
Q
A
T
I
D
L
I
D
G
R
Q
P
P
G
I
L
A
L
L
D
E
Q
S
V
F
P
N
A
T
D
N
T
L
I
T
----
K
L
H
S
H
F
--
S
K
K
NA
K
Y
E
--------
E
P
R
-----
F
S
K
T
E
----------
F
G
V
T
H
Y
A
G
Q
V
M
Y
E
I
Q
D
W
L
E
K
N
K
D
P
L
Q
Q
D
L
E
L
C
F
K
D
S
S
D
-
N
V
V
T
K
L
F
N
D
P
-----
N
I
A
-----------------
S
R
A
-----
F
I
---------------
T
V
A
A
Q
Y
K
E
Q
L
A
S
L
M
A
T
L
E
T
T
N
P
H
F
V
R
C
I
I
P
N
N
K
Q
L
P
A
K
L
E
D
K
V
V
L
D
Q
L
R
C
N
G
V
L
E
G
I
R
I
T
R
K
G
F
P
N
R
I
I
Y
A
D
F
V
K
R
Y
--
Y
L
L
A
P
N
V
-
P
R
D
A
E
D
S
--
Q
K
A
T
D
-
A
V
L
K
H
L
N
I
--
D
PE
Q
Y
R
F
G
I
T
K
I
F
F
R
A
G
Q
L
A
R
I
E
E
A
R
E
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
45
PsiBlast_CBE
80.45
35%
-96
- C2 -
1W7I
1
MYO5A_CHICK
A:
[71-791]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
N
D
L
T
A
L
S
Y
L
H
E
P
A
V
L
H
N
L
K
V
R
F
I
D
S
K
L
I
Y
T
Y
C
G
I
V
L
V
A
I
N
P
Y
E
Q
L
-
P
I
Y
G
E
D
I
I
N
A
Y
S
G
Q
N
M
G
D
M
D
P
H
I
F
A
V
A
E
E
A
Y
K
Q
M
A
R
D
E
R
N
Q
S
I
I
V
S
G
E
S
G
A
G
K
T
V
S
A
K
Y
A
M
R
Y
F
A
T
V
S
G
S
A
---
S
E
A
----
N
V
E
E
K
V
L
A
S
N
P
I
M
E
S
I
G
N
A
K
T
T
R
N
D
N
S
S
R
F
G
K
Y
I
E
I
G
F
D
K
R
Y
R
I
I
G
A
N
M
R
T
Y
L
L
E
K
S
R
V
V
F
Q
A
E
E
E
R
N
Y
H
I
F
Y
Q
L
C
A
S
A
--------
A
L
P
E
F
K
T
L
R
L
G
N
A
N
Y
F
H
Y
T
K
Q
-
G
G
S
P
-
V
I
D
G
--
I
---
D
D
A
K
E
----------
M
V
N
T
R
Q
A
C
---
T
L
L
G
I
S
D
S
Y
Q
M
G
I
F
R
I
L
A
G
I
L
H
L
G
N
V
E
F
A
S
R
D
S
----
D
S
C
A
I
P
P
K
H
D
P
L
T
I
F
C
D
L
M
G
-
V
D
Y
E
E
M
A
H
W
L
C
H
R
K
L
A
---------
T
Y
I
K
P
I
S
K
L
H
A
I
N
A
R
D
A
L
A
K
H
I
Y
A
N
L
F
N
W
I
V
D
H
V
N
K
A
L
H
-----
S
T
V
K
Q
H
S
F
I
G
V
L
D
I
Y
G
F
E
T
F
E
I
N
S
F
E
Q
F
C
I
N
Y
A
N
E
K
L
Q
Q
Q
F
N
M
H
V
F
K
L
E
Q
E
E
Y
M
K
E
Q
I
P
W
T
L
I
D
F
Y
-
D
N
Q
P
C
I
N
L
-
I
-
E
A
K
M
G
V
L
D
L
L
D
E
E
C
K
M
P
K
G
S
D
D
T
W
A
Q
----
K
L
Y
N
T
H
LN
K
C
A
--
L
F
E
--------
K
P
R
-----
L
S
N
K
A
----------
F
I
I
K
H
F
A
D
K
V
E
Y
Q
C
E
G
F
L
E
K
N
K
D
T
V
Y
E
E
Q
I
K
V
L
K
S
S
K
K
F
K
L
L
P
E
L
F
Q
-------------------------------------------------
H
K
K
T
V
G
H
Q
F
R
N
S
L
H
L
L
M
E
T
L
N
A
T
T
P
H
Y
V
R
C
I
K
P
N
D
F
K
F
P
F
T
F
D
E
K
R
A
V
Q
Q
L
R
A
C
G
V
L
E
T
I
R
I
S
A
A
G
F
P
S
R
W
T
Y
Q
E
F
F
S
R
Y
--
R
V
L
---
M
-
K
Q
K
D
V
L
S
D
R
K
Q
T
C
K
-
N
V
L
E
K
L
I
L
DK
D
--
K
Y
Q
F
G
K
T
K
I
F
F
R
A
G
Q
V
A
Y
L
E
K
I
R
A
D
K
L
R
A
A
C
I
-
R
I
Q
K
T
I
R
G
W
L
M
R
K
K
Y
M
R
M
R
R
G
D
A
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
29
PsiBlast_CBE
80.43
35%
-98
- C2 -
1D1C
1
MYS2_DICDI
A:
[89-747]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
D
M
S
E
L
S
Y
L
N
E
P
A
V
F
H
N
L
R
V
R
Y
N
Q
-
D
L
I
Y
T
Y
S
G
L
F
L
V
A
V
N
P
F
K
R
I
-
P
I
Y
T
Q
E
M
V
D
I
F
K
G
R
R
R
N
E
V
A
P
H
I
F
A
I
S
D
V
A
Y
R
S
M
L
D
D
R
Q
N
Q
S
L
L
I
T
G
E
S
G
A
G
K
T
E
N
T
K
K
V
I
Q
Y
L
-
A
S
V
A
G
R
---
N
Q
A
G---
V
L
E
Q
Q
I
L
Q
A
N
P
I
L
E
A
F
G
N
A
K
T
T
R
N
N
N
S
S
R
F
G
K
F
I
E
I
Q
F
N
N
A
G
F
I
S
G
A
S
I
Q
S
Y
L
L
E
K
S
R
V
V
F
Q
S
E
T
E
R
N
Y
H
I
F
Y
Q
L
L
A
G
A
T
-------
A
E
E
K
K
A
-
L
H
L
A
G
P
E
S
F
N
Y
L
-
N
-
Q
S
G
C
-
V
--
D
--
I
K
G
V
-
S
D
S
E
----------
E
F
K
I
T
R
Q
A
--
M
D
I
V
G
F
S
Q
E
E
Q
M
S
I
F
K
I
I
A
G
I
L
H
L
G
N
I
K
F
E
K
G
A
G
E
G
A
V
L
K
D
K
T
-----
A
L
N
A
A
S
T
V
F
G
-
V
N
P
S
V
L
E
K
A
L
M
E
P
R
I
L
A
-----
G
R
D
L
V
A
Q
H
L
N
V
E
K
S
S
S
S
R
D
A
L
V
K
A
L
Y
G
R
L
F
L
W
L
V
K
K
I
N
N
V
L
------
C
Q
E
R
K
A
Y
F
I
G
V
L
D
I
S
G
F
E
I
F
K
V
N
S
F
E
Q
L
C
I
N
Y
T
N
E
K
L
Q
Q
F
F
N
H
H
M
F
K
L
E
Q
E
E
Y
L
K
E
K
I
N
-------L
D
S
Q
A
T
I
D
L
I
D
G
R
Q
P
P
G
I
L
A
L
L
D
E
Q
S
V
F
P
N
A
T
D
N
T
L
I
T
----
K
L
H
S
H
F
--
S
K
K
NA
K
Y
E
--------
E
P
R
-----
F
S
K
T
E
----------
F
G
V
T
H
Y
A
G
Q
V
M
Y
E
I
Q
D
W
L
E
K
N
K
D
P
L
Q
Q
D
L
E
L
C
F
K
D
S
S
D
-
N
V
V
T
K
L
F
N
D
P
-----
N
I
A
-----------------
S
R
----
A
N
F
I
---------------
T
V
A
A
Q
Y
K
E
Q
L
A
S
L
M
A
T
L
E
T
T
N
P
H
F
V
R
C
I
I
P
N
N
K
Q
L
P
A
K
L
E
D
K
V
V
L
D
Q
L
R
C
N
G
V
L
E
G
I
R
I
T
R
K
G
F
P
N
R
I
I
Y
A
D
F
V
K
R
Y
--
Y
L
L
A
P
N
V
-
P
R
D
A
E
D
S
--
Q
K
A
T
D
-
A
V
L
K
H
L
N
I
--
D
PE
Q
Y
R
F
G
I
T
K
I
F
F
R
A
G
Q
L
A
R
I
E
E
A
R
E
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
39
PsiBlast_CBE
80.34
35%
-100
- C2 -
1FMW
1
MYS2_DICDI
A:
[89-747]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
D
M
S
E
L
S
Y
L
N
E
P
A
V
F
H
N
L
R
V
R
Y
N
Q
-
D
L
I
Y
T
Y
S
G
L
F
L
V
A
V
N
P
F
K
R
I
-
P
I
Y
T
Q
E
M
V
D
I
F
K
G
R
R
R
N
E
V
A
P
H
I
F
A
I
S
D
V
A
Y
R
S
M
L
D
D
R
Q
N
Q
S
L
L
I
T
G
E
S
G
A
G
K
T
E
N
T
K
K
V
I
Q
Y
L
-
A
S
V
A
G
R
------G---
V
L
E
Q
Q
I
L
Q
A
N
P
I
L
E
A
F
G
N
A
K
T
T
R
N
N
N
S
S
R
F
G
K
F
I
E
I
Q
F
N
N
A
G
F
I
S
G
A
S
I
Q
S
Y
L
L
E
K
S
R
V
V
F
Q
S
E
T
E
R
N
Y
H
I
F
Y
Q
L
L
A
G
A
T
-------
A
E
E
K
K
A
-
L
H
L
A
G
P
E
S
F
N
Y
L
-
N
-
Q
S
G
C
-
V
--
D
--
I
K
G
V
-
S
D
S
E
----------
E
F
K
I
T
R
Q
A
--
M
D
I
V
G
F
S
Q
E
E
Q
M
S
I
F
K
I
I
A
G
I
L
H
L
G
N
I
K
F
E
K
G
A
G
E
G
A
V
L
K
D
K
T
-----
A
L
N
A
A
S
T
V
F
G
-
V
N
P
S
V
L
E
K
A
L
M
E
P
R
I
L
A
-----
G
R
D
L
V
A
Q
H
L
N
V
E
K
S
S
S
S
R
D
A
L
V
K
A
L
Y
G
R
L
F
L
W
L
V
K
K
I
N
N
V
L
------
C
Q
E
R
K
A
Y
F
I
G
V
L
D
I
S
G
F
E
I
F
K
V
N
S
F
E
Q
L
C
I
N
Y
T
N
E
K
L
Q
Q
F
F
N
H
H
M
F
K
V
E
Q
E
E
Y
L
K
E
K
I
---------
D
S
Q
A
T
I
D
L
I
D
G
R
Q
P
P
G
I
L
A
L
L
D
E
Q
S
V
F
P
N
A
T
D
N
T
L
I
T
----
K
L
H
S
H
F
--
S
K
K
NA
K
Y
E
--------
E
P
R
-----
F
S
K
T
E
----------
F
G
V
T
H
Y
A
G
Q
V
M
Y
E
I
Q
D
W
L
E
K
N
K
D
P
L
Q
Q
D
L
E
L
C
F
K
D
S
S
D
-
N
V
V
T
K
L
F
N
D
P
-----
N
I
A
-----------------
S
R
A
-----
F
I
---------------
T
V
A
A
Q
Y
K
E
Q
L
A
S
L
M
A
T
L
E
T
T
N
P
H
F
V
R
C
I
I
P
N
N
K
Q
L
P
A
K
L
E
D
K
V
V
L
D
Q
L
R
C
N
G
V
L
E
G
I
R
I
T
R
K
G
F
P
N
R
I
I
Y
A
D
F
V
K
R
Y
--
Y
L
L
A
P
N
V
-
P
R
D
A
E
D
S
--
Q
K
A
T
D
-
A
V
L
K
H
L
N
I
--
D
PE
Q
Y
R
F
G
I
T
K
I
F
F
R
A
G
Q
L
A
R
I
E
E
A
R
E
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
61
PsiBlast_CBE
80.15
33%
-94
- C2 -
1QVI
1
MYS_ARGIR
A:
[86-825]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
D
M
A
N
M
T
Y
L
N
E
A
S
V
L
Y
N
L
R
S
R
Y
T
S
-
G
L
I
Y
T
Y
S
G
L
F
C
I
A
V
N
P
Y
R
R
L
-
P
I
Y
T
D
S
V
I
A
K
Y
R
G
K
R
K
T
E
I
P
P
H
L
F
S
V
A
D
N
A
Y
Q
N
M
V
T
D
R
E
N
Q
S
C
L
I
T
G
E
S
G
A
G
K
T
E
N
T
K
K
V
I
M
Y
L
-
A
K
V
A
C
A
---
V
K
-EG--
S
L
E
D
Q
I
I
Q
A
N
P
V
L
E
A
Y
G
N
A
K
T
T
R
N
N
N
S
S
R
F
G
K
F
I
R
I
H
F
G
P
T
G
K
I
A
G
A
D
I
E
T
Y
L
L
E
K
S
R
V
T
Y
Q
Q
S
A
E
R
N
Y
H
I
F
Y
Q
I
C
S
--
N
-------
A
I
P
E
L
N
D
V
M
L
V
T
P
D
S
G
L
Y
S
F
I
-
N
Q
G
C
-
L
T
V
D
N-
I
D
D
V
E
--------------
E
F
K
L
C
D
E
A
--
F
D
I
L
G
F
T
K
E
E
K
Q
S
M
F
K
C
T
A
S
I
L
H
M
G
E
M
K
F
K
Q
R
P
R
E
E
Q
A
E
S
D
G
T
-
A
E
A
E
K
V
----
A
F
L
C
G
I
N
A
G
D
L
L
K
A
L
L
K
P
K
V
K
V
-----
G
T
E
M
V
T
K
G
Q
N
M
N
Q
V
V
N
S
V
G
A
L
A
K
S
L
Y
D
R
M
F
N
W
L
V
R
R
V
N
K
T
L
D
-----
T
K
A
K
R
N
Y
Y
I
G
V
L
D
I
A
G
F
E
I
F
D
F
N
S
F
E
Q
L
C
I
N
Y
T
N
E
R
L
Q
Q
F
F
N
H
H
M
F
I
L
E
Q
E
E
Y
K
K
E
G
I
A
W
E
F
I
D
F
G
-
M
D
L
Q
M
C
I
D
L
I
-
E
K
P
M
G
I
L
S
I
L
E
E
E
C
M
F
P
K
A
D
D
K
S
F
Q
D
----
K
L
Y
Q
N
H
--
M
G
K
--
N
R
M
FTKPGKPT
R
P
N
-----
Q
G
P
A
H
----------
F
E
L
H
H
Y
A
G
N
V
P
Y
S
I
T
G
W
L
E
K
N
K
D
P
I
N
E
N
V
V
A
L
L
G
A
S
K
E
-
P
L
V
A
E
L
F
K
A
P
E
E
------------------
F
----------------------------
Q
T
I
S
A
V
H
R
E
S
L
N
K
L
M
K
N
L
Y
S
T
H
P
H
F
V
R
C
I
I
P
N
E
L
K
Q
P
G
L
V
D
A
E
L
V
L
H
Q
L
Q
C
N
G
V
L
E
G
I
R
I
C
R
K
G
F
P
S
R
L
I
Y
S
E
F
K
Q
R
Y
--
S
I
L
A
P
N
A
I
P
--
F
V
D
G
--
K
T
V
S
E
-
K
I
L
A
G
L
Q
M
--
D
PA
E
Y
R
L
G
T
T
K
V
F
F
K
A
G
V
L
G
N
L
E
E
M
R
D
E
R
L
-
S
K
I
I
S
M
F
Q
A
H
I
R
G
Y
L
I
R
K
A
Y
K
K
L
Q
D
Q
R
-
I
G
L
S
V
I
Q
---
R
N
I
---
R
K
W
L
V
L
R
N
W
Q
W
W
K
L
Y
S
K
V
K
P
L
L
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
20
PsiBlast_PDB
79.89
35%
-97
- C2 -
1JWY
2
MYS2_DICDI
A:
[100-758]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
D
M
S
E
L
S
Y
L
N
E
P
A
V
F
H
N
L
R
V
R
Y
N
Q
-
D
L
I
Y
T
Y
S
G
L
F
L
V
A
V
N
P
F
K
R
I
-
P
I
Y
T
Q
E
M
V
D
I
F
K
G
R
R
R
N
E
V
A
P
H
I
F
A
I
S
D
V
A
Y
R
S
M
L
D
D
R
Q
N
Q
S
L
L
I
T
G
E
S
G
A
G
K
T
E
N
T
K
K
V
I
Q
Y
L
-
A
S
V
A
G
-------SG--
V
L
E
Q
Q
I
L
Q
A
N
P
I
L
E
A
F
G
N
A
K
T
T
R
N
N
N
S
S
R
F
G
K
F
I
E
I
Q
F
N
S
A
G
F
I
S
G
A
S
I
Q
S
Y
L
L
E
K
S
R
V
V
F
Q
S
E
T
E
R
N
Y
H
I
F
Y
Q
L
L
A
G
A
T
-------
A
E
E
K
K
A
-
L
H
L
A
G
P
E
S
F
N
Y
L
-
N
-
Q
S
G
C
-
V
--
D
--
I
K
G
V
-
S
D
S
E
----------
E
F
K
I
T
R
Q
A
--
M
D
I
V
G
F
S
Q
E
E
Q
M
S
I
F
K
I
I
A
G
I
L
H
L
G
N
I
K
F
E
K
G
A
G
E
G
A
V
L
K
D
K
T
-----
A
L
N
A
A
S
T
V
F
G
-
V
N
P
S
V
L
E
K
A
L
M
E
P
R
I
L
A
-----
G
R
D
L
V
A
Q
H
L
N
V
E
K
S
S
S
S
R
D
A
L
V
K
A
L
Y
G
R
L
F
L
W
L
V
K
K
I
N
N
V
L
------
C
Q
E
R
K
A
Y
F
I
G
V
L
D
I
S
G
F
E
I
F
K
V
N
S
F
E
Q
L
C
I
N
Y
T
N
E
K
L
Q
Q
F
F
N
H
H
M
F
K
L
E
Q
E
E
Y
L
K
E
K
I
N
W
T
F
I
D
F
G
L
D
S
Q
A
T
I
D
L
I
D
G
R
Q
P
P
G
I
L
A
L
L
D
E
Q
S
V
F
P
N
A
T
D
N
T
L
I
T
----
K
L
H
S
H
F
--
S
K
K
NA
K
Y
E
--------
E
P
R
-----
F
S
K
T
E
----------
F
G
V
T
H
Y
A
G
Q
V
M
Y
E
I
Q
D
W
L
E
K
N
K
D
P
L
Q
Q
D
L
E
L
C
F
K
D
S
S
D
-
N
V
V
T
K
L
F
N
D
P
-----
N
I
A
-----------------
S
R
A
K
K
G
A
N
F
I
---------------
T
V
A
A
Q
Y
K
E
Q
L
A
S
L
M
A
T
L
E
T
T
N
P
H
F
V
R
C
I
I
P
N
N
K
Q
L
P
A
K
L
E
D
K
V
V
L
D
Q
L
R
C
N
G
V
L
E
G
I
R
I
T
R
K
G
F
P
N
R
I
I
Y
A
D
F
V
K
R
Y
--
Y
L
L
A
P
N
V
-
P
R
D
A
E
D
S
--
Q
K
A
T
D
-
A
V
L
K
H
L
N
I
--
D
PE
Q
Y
R
F
G
I
T
K
I
F
F
R
A
G
Q
L
A
R
I
E
E
A
R
E
Q
R
I
-
S
E
I
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
58
PsiBlast_CBE
79.88
33%
-98
- C2 -
1KK8
2
MYS_ARGIR
A:
[86-825]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
D
M
A
N
M
T
Y
L
N
E
A
S
V
L
Y
N
L
R
S
R
Y
T
S
-
G
L
I
Y
T
Y
S
G
L
F
C
I
A
V
N
P
Y
R
R
L
-
P
I
Y
T
D
S
V
I
A
K
Y
R
G
K
R
K
T
E
I
P
P
H
L
F
S
V
A
D
N
A
Y
Q
N
M
V
T
D
R
E
N
Q
S
C
L
I
T
G
E
S
G
A
G
K
T
E
N
T
K
K
V
I
M
Y
L
-
A
K
V
A
C
A
---
V
K
K
KEG-
S
L
E
D
Q
I
I
Q
A
N
P
V
L
E
A
Y
G
N
A
K
T
T
R
N
N
N
S
S
R
F
G
K
F
I
R
I
H
F
G
P
T
G
K
I
A
G
A
D
I
E
T
Y
L
L
E
K
S
R
V
T
Y
Q
Q
S
A
E
R
N
Y
H
I
F
Y
Q
I
C
S
--
N
-------
A
I
P
E
L
N
D
V
M
L
V
T
P
D
S
G
L
Y
S
F
I
-
N
Q
G
C
-
L
T
V
D
N-
I
D
D
V
E
--------------
E
F
K
L
C
D
E
A
--
F
D
I
L
G
F
T
K
E
E
K
Q
S
M
F
K
C
T
A
S
I
L
H
M
G
E
M
K
F
K
Q
----
E
Q
A
E
S
D
G
T
-
A
E
A
E
K
V
----
A
F
L
C
G
I
N
A
G
D
L
L
K
A
L
L
K
P
K
V
K
---------
M
V
T
K
G
Q
N
M
N
Q
V
V
N
S
V
G
A
L
A
K
S
L
Y
D
R
M
F
N
W
L
V
R
R
V
N
K
T
L
D
-----
T
K
A
K
R
N
Y
Y
I
G
V
L
D
I
A
G
F
E
I
F
D
F
N
S
F
E
Q
L
C
I
N
Y
T
N
E
R
L
Q
Q
F
F
N
H
H
M
F
I
L
E
Q
E
E
Y
K
K
E
G
I
A
W
E
F
I
D
F
G
-
M
D
L
Q
M
C
I
D
L
I
-
E
K
P
M
G
I
L
S
I
L
E
E
E
C
M
F
P
K
A
D
D
K
S
F
Q
D
----
K
L
Y
Q
N
H
--
M
G
K
--
N
R
M
FTKPGKPT
R
P
N
-----
Q
G
P
A
H
----------
F
E
L
H
H
Y
A
G
N
V
P
Y
S
I
T
G
W
L
E
K
N
K
D
P
I
N
E
N
V
V
A
L
L
G
A
S
K
E
-
P
L
V
A
E
L
F
K
A
--------------------------------------------------
Q
T
I
S
A
V
H
R
E
S
L
N
K
L
M
K
N
L
Y
S
T
H
P
H
F
V
R
C
I
I
P
N
E
L
K
Q
P
G
L
V
D
A
E
L
V
L
H
Q
L
Q
C
N
G
V
L
E
-----
R
K
G
F
P
S
R
L
I
Y
S
E
F
K
Q
R
Y
--
S
I
L
A
P
N
A
I
P
Q
---
D
G
--
K
T
V
S
E
-
K
I
L
A
G
L
Q
M
--
D
PA
E
Y
R
L
G
T
T
K
V
F
F
K
A
G
V
L
G
N
L
E
E
M
R
D
E
R
L
-
S
K
I
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M
F
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A
H
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R
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Y
L
I
R
K
A
Y
K
K
L
Q
D
Q
R
-
I
G
L
S
V
I
Q
---
R
N
I
---
R
K
W
L
V
L
R
N
W
Q
W
W
K
L
Y
S
K
V
K
P
L
L
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
6
PsiBlast_PDB
79.81
35%
-97
- C2 -
1W9J
5
MYS2_DICDI
A:
[89-747]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
D
M
S
E
L
S
Y
L
N
E
P
A
V
F
H
N
L
R
V
R
Y
N
Q
-
D
L
I
Y
T
Y
S
G
L
F
L
V
A
V
N
P
F
K
R
I
-
P
I
Y
T
Q
E
M
V
D
I
F
K
G
R
R
R
N
E
V
A
P
H
I
F
A
I
S
D
V
A
Y
R
S
M
L
D
D
R
Q
N
Q
S
L
L
I
T
G
E
S
G
A
G
K
T
E
N
T
K
K
V
I
Q
Y
L
-
A
S
V
A
G
R
------G---
V
L
E
Q
Q
I
L
Q
A
N
P
I
L
E
A
F
G
N
A
K
T
T
R
N
N
N
S
S
R
F
G
K
F
I
E
I
Q
F
N
S
A
G
F
I
S
G
A
S
I
Q
S
Y
L
L
E
K
S
R
V
V
F
Q
S
E
T
E
R
N
Y
H
I
F
Y
Q
L
L
A
G
A
T
-------
A
E
E
K
K
A
-
L
H
L
A
G
P
E
S
F
N
Y
L
-
N
-
Q
S
G
C
-
V
--
D
--
I
K
G
V
-
S
D
S
E
----------
E
F
K
I
T
R
Q
A
--
M
D
I
V
G
F
S
Q
E
E
Q
M
S
I
F
K
I
I
A
G
I
L
H
L
G
N
I
K
F
E
K
G
A
G
E
G
A
V
L
K
D
K
T
-----
A
L
N
A
A
S
T
V
F
G
-
V
N
P
S
V
L
E
K
A
L
M
E
P
R
I
L
A
-----
G
R
D
L
V
A
Q
H
L
N
V
E
K
S
S
S
S
R
D
A
L
V
K
A
L
Y
G
R
L
F
L
W
L
V
K
K
I
N
N
V
L
------
C
Q
E
R
K
A
Y
F
I
G
V
L
D
I
Y
G
F
E
I
F
K
V
N
S
F
E
Q
L
C
I
N
Y
T
N
E
K
L
Q
Q
F
F
N
H
H
M
F
K
L
E
Q
E
E
Y
L
K
E
K
I
N
W
T
F
I
D
F
G
L
D
S
Q
A
T
I
D
L
I
D
G
R
Q
P
P
G
I
L
A
L
L
D
E
Q
S
V
F
P
N
A
T
D
N
T
L
I
T
----
K
L
H
S
H
F
--
S
K
K
NA
K
Y
E
--------
E
P
R
-----
F
S
K
T
E
----------
F
G
V
T
H
Y
A
G
Q
V
M
Y
E
I
Q
D
W
L
E
K
N
K
D
P
L
Q
Q
D
L
E
L
C
F
K
D
S
S
D
-
N
V
V
T
K
L
F
N
D
P
-----
N
I
A
-----------------
S
R
A
K
K
G
A
N
F
I
---------------
T
V
A
A
Q
Y
K
E
Q
L
A
S
L
M
A
T
L
E
T
T
N
P
H
F
V
R
C
I
I
P
N
N
K
Q
L
P
A
K
L
E
D
K
V
V
L
D
Q
L
R
C
N
G
V
L
E
G
I
R
I
T
R
K
G
F
P
N
R
I
I
Y
A
D
F
V
K
R
Y
----------------
S
--
Q
K
A
T
D
-----------
D
PE
Q
Y
R
F
G
I
T
K
I
F
F
R
A
G
Q
L
A
R
I
E
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
32
PsiBlast_CBE
79.43
35%
-97
- C2 -
1D0Y
1
MYS2_DICDI
A:
[89-747]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
D
M
S
E
L
S
Y
L
N
E
P
A
V
F
H
N
L
R
V
R
Y
N
Q
-
D
L
I
Y
T
Y
S
G
L
F
L
V
A
V
N
P
F
K
R
I
-
P
I
Y
T
Q
E
M
V
D
I
F
K
G
R
R
R
N
E
V
A
P
H
I
F
A
I
S
D
V
A
Y
R
S
M
L
D
D
R
Q
N
Q
S
L
L
I
T
G
E
S
G
A
G
K
T
E
N
T
K
K
V
I
Q
Y
L
-
A
S
V
A
G
R
---
N
--G---
V
L
E
Q
Q
I
L
Q
A
N
P
I
L
E
A
F
G
N
A
K
T
T
R
N
N
N
S
S
R
F
G
K
F
I
E
I
Q
F
N
N
A
G
F
I
S
G
A
S
I
Q
S
Y
L
L
E
K
S
R
V
V
F
Q
S
E
T
E
R
N
Y
H
I
F
Y
Q
L
L
A
G
A
T
-------
A
E
E
K
K
A
-
L
H
L
A
G
P
E
S
F
N
Y
L
-
N
-
Q
S
G
C
-
V
--
D
--
I
K
G
V
-
S
D
S
E
----------
E
F
K
I
T
R
Q
A
--
M
D
I
V
G
F
S
Q
E
E
Q
M
S
I
F
K
I
I
A
G
I
L
H
L
G
N
I
K
F
E
K
G
A
G
E
G
A
V
L
K
D
K
T
-----
A
L
N
A
A
S
T
V
F
G
-
V
N
P
S
V
L
E
K
A
L
M
E
P
R
I
L
A
-----
G
R
D
L
V
A
Q
H
L
N
V
E
K
S
S
S
S
R
D
A
L
V
K
A
L
Y
G
R
L
F
L
W
L
V
K
K
I
N
N
V
L
------
C
Q
E
R
K
A
Y
F
I
G
V
L
D
I
S
G
F
E
I
F
K
V
N
S
F
E
Q
L
C
I
N
Y
T
N
E
K
L
Q
Q
F
F
N
H
H
M
F
K
L
E
Q
E
E
Y
L
K
E
K
I
N
-------L
D
S
Q
A
T
I
D
L
I
D
G
R
Q
P
P
G
I
L
A
L
L
D
E
Q
S
V
F
P
N
A
T
D
N
T
L
I
T
----
K
L
H
S
H
F
--
S
K
K
NA
K
Y
E
--------
E
P
R
-----
F
S
K
T
E
----------
F
G
V
T
H
Y
A
G
Q
V
M
Y
E
I
Q
D
W
L
E
K
N
K
D
P
L
Q
Q
D
L
E
L
C
F
K
D
S
S
D
-
N
V
V
T
K
L
F
N
D
P
-----
N
I
A
-----------------
S
R
A
-----
F
I
---------------
T
V
A
A
Q
Y
K
E
Q
L
A
S
L
M
A
T
L
E
T
T
N
P
H
F
V
R
C
I
I
P
N
N
K
Q
L
P
A
K
L
E
D
K
V
V
L
D
Q
L
R
C
N
G
V
L
E
G
I
R
I
T
R
K
G
F
P
N
R
I
I
Y
A
D
F
V
K
R
Y
--
Y
L
L
A
P
N
V
-
P
R
D
A
E
D
S
--
Q
K
A
T
D
-
A
V
L
K
H
L
N
I
--
D
PE
Q
Y
R
F
G
I
T
K
I
F
F
R
A
G
Q
L
A
R
I
E
E
A
R
E
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
5
PsiBlast_PDB
79.28
35%
-96
- C2 -
1MMG
1
MYS2_DICDI
A:
[89-747]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
D
M
S
E
L
S
Y
L
N
E
P
A
V
F
H
N
L
R
V
R
Y
N
Q
-
D
L
I
Y
T
Y
S
G
L
F
L
V
A
V
N
P
F
K
R
I
-
P
I
Y
T
Q
E
M
V
D
I
F
K
G
R
R
R
N
E
V
A
P
H
I
F
A
I
S
D
V
A
Y
R
S
M
L
D
D
R
Q
N
Q
S
L
L
I
T
G
E
S
G
A
G
K
T
E
N
T
K
K
V
I
Q
Y
L
-
A
S
V
A
G
R
---
N
--G---
V
L
E
Q
Q
I
L
Q
A
N
P
I
L
E
A
F
G
N
A
K
T
T
R
N
N
N
S
S
R
F
G
K
F
I
E
I
Q
F
N
N
A
G
F
I
S
G
A
S
I
Q
S
Y
L
L
E
K
S
R
V
V
F
Q
S
T
T
E
R
N
Y
H
I
F
Y
Q
L
L
A
G
A
T
-------
A
E
E
K
K
A
-
L
H
L
A
G
P
E
S
F
N
Y
L
-
N
-
Q
S
G
C
-
V
D
I
K
--
G
V
S
D
E
D
-------------
E
F
K
I
T
R
Q
A
--
M
D
I
V
G
F
S
Q
E
E
Q
M
S
I
F
K
I
I
A
G
I
L
H
L
G
N
I
K
F
E
K
G
A
G
E
G
A
V
L
K
D
K
T
-----
A
L
N
A
A
S
T
V
F
G
-
V
N
P
S
V
L
E
K
A
L
M
E
P
R
I
L
A
-----
G
R
D
L
V
A
Q
H
L
N
V
E
K
S
S
S
S
R
D
A
L
V
K
A
L
Y
G
R
L
F
L
W
L
V
K
K
I
N
N
V
L
------
C
S
E
R
K
A
Y
F
I
G
V
L
D
I
S
G
F
E
I
F
K
V
N
S
F
E
Q
L
C
I
N
Y
T
N
E
K
L
Q
Q
F
F
N
H
H
M
F
K
V
E
Q
E
E
Y
L
K
E
K
I
N
-------L
D
S
Q
A
T
I
D
L
I
D
G
R
Q
P
P
G
I
L
A
L
L
D
E
Q
S
V
F
P
N
A
T
D
N
T
L
I
T
----
K
L
H
S
H
F
--
S
K
K
NA
K
Y
E
--------
E
P
R
-----
F
S
K
T
E
----------
F
G
V
T
H
Y
A
G
Q
V
M
Y
E
I
Q
D
W
L
E
K
N
K
D
P
L
Q
Q
D
L
E
L
C
F
K
D
S
S
D
-
N
V
V
T
K
L
F
N
D
P
-----
N
I
A
-----------------
S
R
A
-----
F
L
---------------
T
V
A
A
Q
Y
K
E
Q
L
A
S
L
M
A
T
L
E
T
T
N
P
H
F
V
R
C
I
I
P
N
N
K
Q
L
P
A
K
L
E
D
K
V
V
L
D
Q
L
R
C
N
G
V
L
E
A
I
R
I
T
R
K
G
F
P
N
R
I
I
Y
A
D
F
V
K
R
Y
--
Y
D
L
A
P
N
V
-
P
R
D
A
E
D
S
--
Q
K
A
T
D
-
A
V
L
K
H
L
N
I
--
D
PE
Q
F
R
F
G
I
T
K
I
F
F
R
A
G
Q
L
A
R
I
E
E
A
R
E
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
35
PsiBlast_CBE
79.27
35%
-98
- C2 -
1MMA
1
MYS2_DICDI
A:
[89-747]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
D
M
S
E
L
S
Y
L
N
E
P
A
V
F
H
N
L
R
V
R
Y
N
Q
-
D
L
I
Y
T
Y
S
G
L
F
L
V
A
V
N
P
F
K
R
I
-
P
I
Y
T
Q
E
M
V
D
I
F
K
G
R
R
R
N
E
V
A
P
H
I
F
A
I
S
D
V
A
Y
R
S
M
L
D
D
R
Q
N
Q
S
L
L
I
T
G
E
S
G
A
G
K
T
E
N
T
K
K
V
I
Q
Y
L
-
A
S
V
A
G
R
---
N
Q
-G---
V
L
E
Q
Q
I
L
Q
A
N
P
I
L
E
A
F
G
N
A
K
T
T
R
N
N
N
S
S
R
F
G
K
F
I
E
I
Q
F
N
N
A
G
F
I
S
G
A
S
I
Q
S
Y
L
L
E
K
S
R
V
V
F
Q
S
E
T
E
R
N
Y
H
I
F
Y
Q
L
L
A
G
A
T
-------
A
E
E
K
K
A
-
L
H
L
A
G
P
E
S
F
N
Y
L
-
N
-
Q
S
G
C
-
V
--
D
--
I
K
G
V
-
S
D
S
E
----------
E
F
K
I
T
R
Q
A
--
M
D
I
V
G
F
S
Q
E
E
Q
M
S
I
F
K
I
I
A
G
I
L
H
L
G
N
I
K
F
E
K
G
A
G
E
G
A
V
L
K
D
K
T
-----
A
L
N
A
A
S
T
V
F
G
-
V
N
P
S
V
L
E
K
A
L
M
E
P
R
I
L
A
-----
G
R
D
L
V
A
Q
H
L
N
V
E
K
S
S
S
S
R
D
A
L
V
K
A
L
Y
G
R
L
F
L
W
L
V
K
K
I
N
N
V
L
------
C
Q
E
R
K
A
Y
F
I
G
V
L
D
I
S
G
F
E
I
F
K
V
N
S
F
E
Q
L
C
I
N
Y
T
N
E
K
L
Q
Q
F
F
N
H
H
M
F
K
L
E
Q
E
E
Y
L
K
E
------
I
D
F
G
L
D
S
Q
A
T
I
D
L
I
D
G
R
Q
P
P
G
I
L
A
L
L
D
E
Q
S
V
F
P
N
A
T
D
N
T
L
I
T
----
K
L
H
S
H
F
--
S
K
K
NA
K
Y
E
--------
E
P
R
-----
F
S
K
T
E
----------
F
G
V
T
H
Y
A
G
Q
V
M
Y
E
I
Q
D
W
L
E
K
N
K
D
P
L
Q
Q
D
L
E
L
C
F
K
D
S
S
D
-
N
V
V
T
K
L
F
N
D
P
-----
N
I
A
-----------------
S
R
----
A
N
F
I
---------------
T
V
A
A
Q
Y
K
E
Q
L
A
S
L
M
A
T
L
E
T
T
N
P
H
F
V
R
C
I
I
P
N
N
K
Q
L
P
A
K
L
E
D
K
V
V
L
D
Q
L
R
C
N
G
V
L
E
G
I
R
I
T
R
K
G
F
P
N
R
I
I
Y
A
D
F
-----------------------
Q
K
A
T
D
-
A
V
L
K
H
L
N
I
--
D
PE
Q
F
R
F
G
I
T
K
I
F
F
R
A
G
Q
L
A
R
I
E
E
A
R
E
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
11
PsiBlast_PDB
79.25
35%
-98
- C2 -
1MNE
1
MYS2_DICDI
A:
[89-747]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
D
M
S
E
L
S
Y
L
N
E
P
A
V
F
H
N
L
R
V
R
Y
N
Q
-
D
L
I
Y
T
Y
S
G
L
F
L
V
A
V
N
P
F
K
R
I
-
P
I
Y
T
Q
E
M
V
D
I
F
K
G
R
R
R
N
E
V
A
P
H
I
F
A
I
S
D
V
A
Y
R
S
M
L
D
D
R
Q
N
Q
S
L
L
I
T
G
E
S
G
A
G
K
T
E
N
T
K
K
V
I
Q
Y
L
-
A
S
V
A
G
R
---
N
Q
-G---
V
L
E
Q
Q
I
L
Q
A
N
P
I
L
E
A
F
G
N
A
K
T
T
R
N
N
N
S
S
R
F
G
K
F
I
E
I
Q
F
N
N
A
G
F
I
S
G
A
S
I
Q
S
Y
L
L
E
K
S
R
V
V
F
Q
S
E
T
E
R
N
Y
H
I
F
Y
Q
L
L
A
G
A
T
-------
A
E
E
K
K
A
-
L
H
L
A
G
P
E
S
F
N
Y
L
-
N
-
Q
S
G
C
-
V
D
I
K
--
G
V
S
D
E
D
-------------
E
F
K
I
T
R
Q
A
--
M
D
I
V
G
F
S
Q
E
E
Q
M
S
I
F
K
I
I
A
G
I
L
H
L
G
N
I
K
F
E
K
G
A
G
E
G
A
V
L
K
D
K
T
-----
A
L
N
A
A
S
T
V
F
G
-
V
N
P
S
V
L
E
K
A
L
M
E
P
R
I
L
A
-----
G
R
D
L
V
A
Q
H
L
N
V
E
K
S
S
S
S
R
D
A
L
V
K
A
L
Y
G
R
L
F
L
W
L
V
K
K
I
N
N
V
L
------
C
S
E
R
A
A
Y
F
I
G
V
L
D
I
S
G
F
E
I
F
K
V
N
S
F
E
Q
L
C
I
N
Y
T
N
E
K
L
Q
Q
F
F
N
H
H
M
F
K
V
E
Q
E
E
Y
L
K
E
K
I
N
-------L
D
S
Q
A
T
I
D
L
I
D
G
R
Q
P
P
G
I
L
A
L
L
D
E
Q
S
V
F
P
N
A
T
D
N
T
L
I
T
----
K
L
H
S
H
F
--
S
K
K
NA
K
Y
E
--------
E
P
R
-----
F
S
K
T
E
----------
F
G
V
T
H
Y
A
G
Q
V
M
Y
E
I
Q
D
W
L
E
K
N
K
D
P
L
Q
Q
D
L
E
L
C
F
K
D
S
S
D
-
N
V
V
T
K
L
F
N
D
P
-----
N
I
A
-----------------
S
R
A
-----
F
I
---------------
T
V
A
A
Q
Y
K
E
Q
L
A
S
L
M
A
T
L
E
T
T
N
P
H
F
V
R
C
I
I
P
N
N
K
Q
L
P
A
K
L
E
D
K
V
V
L
D
Q
L
R
C
N
G
V
L
E
G
I
R
I
T
R
K
G
F
P
N
R
I
I
Y
A
D
F
V
K
R
Y
--
Y
L
L
A
P
N
V
-
P
R
D
A
E
D
S
--
Q
K
A
T
D
-
A
V
L
K
H
L
N
I
--
D
PE
Q
Y
R
F
G
I
T
K
I
F
F
R
A
G
Q
L
A
R
I
E
E
A
R
E
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
42
PsiBlast_CBE
79.10
35%
-95
- C2 -
2XO8
2
MYS2_DICDI
A:
[88-746]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
D
M
S
E
L
S
Y
L
N
E
P
A
V
F
H
N
L
R
V
R
Y
N
Q
-
D
L
I
Y
T
Y
S
G
L
F
L
V
A
V
N
P
F
K
I
I
-
P
I
Y
T
Q
E
M
V
D
I
F
K
G
R
R
R
N
E
V
A
P
H
I
F
A
I
S
D
V
A
Y
R
S
M
L
D
D
R
Q
N
Q
S
L
L
I
T
G
E
S
G
A
G
K
T
E
N
T
K
K
V
I
Q
Y
L
-
A
S
V
A
G
R
---
N
Q
A
NGSG
V
L
E
Q
Q
I
L
Q
A
N
P
I
L
E
A
F
G
N
A
K
T
T
R
N
N
N
S
S
R
F
G
K
F
I
E
I
Q
F
N
S
A
G
F
I
S
G
A
S
I
Q
S
Y
L
L
E
K
S
R
V
V
F
Q
S
E
T
E
R
N
Y
H
I
F
Y
Q
L
L
A
G
A
T
-------
A
E
E
K
K
A
-
L
H
L
A
G
P
E
S
F
N
Y
L
-
N
-
Q
S
G
C
-
V
--
D
--
I
K
G
V
-
S
D
S
E
----------
E
F
K
I
T
R
Q
A
--
M
D
I
V
G
F
S
Q
E
E
Q
M
S
I
F
K
I
I
A
G
I
L
H
L
G
N
I
K
F
E
K
G
A
G
E
G
A
V
L
K
D
K
T
-----
A
L
N
A
A
S
T
V
F
G
-
V
N
P
S
V
L
E
K
A
L
M
E
P
R
I
L
A
-----
G
R
D
L
V
A
Q
H
L
N
V
E
K
S
S
S
S
R
D
A
L
V
K
A
L
Y
G
R
L
F
L
W
L
V
I
K
I
N
N
V
L
------
C
Q
E
R
K
A
Y
F
I
G
V
L
D
I
S
G
F
E
I
F
K
V
N
S
F
E
Q
L
C
I
N
Y
T
N
E
K
L
Q
Q
F
F
N
H
H
M
F
K
L
E
Q
E
E
Y
L
K
E
K
I
N
W
T
F
I
D
F
G
L
D
S
Q
A
T
I
D
L
I
D
G
R
Q
P
P
G
I
L
A
L
L
D
E
Q
S
V
F
P
N
A
T
D
N
T
L
I
T
----
K
L
H
S
H
F
--
S
K
K
NA
K
Y
E
--------
E
P
R
-----
F
S
K
T
E
----------
F
G
V
T
H
Y
A
G
Q
V
M
Y
E
I
Q
D
W
L
E
K
N
K
D
P
L
Q
Q
D
L
E
L
C
F
K
D
S
S
D
-
N
V
V
T
K
L
F
N
D
P
-----
N
I
A
-----------------
S
R
A
K
K
G
A
N
F
I
---------------
T
V
A
A
Q
Y
K
E
Q
L
A
S
L
M
A
T
L
E
T
T
N
P
H
F
V
R
C
I
I
P
N
N
K
Q
L
P
A
K
L
E
D
K
V
V
L
D
Q
L
R
C
N
G
V
L
E
G
I
R
I
T
R
K
G
F
P
N
R
I
I
Y
A
D
F
V
K
R
Y
--
Y
L
L
A
P
N
V
-
P
R
D
A
E
D
S
--
Q
K
A
T
D
-
A
V
L
K
H
L
N
I
--
D
PE
Q
Y
R
F
G
I
T
K
I
F
F
R
A
G
Q
L
A
R
I
E
E
A
R
E
Q
R
L
-
E
S
N
E
-
P
P
M
D
F
D
D
D
I
P
F
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
43
PsiBlast_CBE
79.07
35%
-99
- C2 -
4PJK
7
MYS2_DICDI
A:
[89-747]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
D
M
S
E
L
S
Y
L
N
E
P
A
V
F
H
N
L
R
V
R
Y
N
Q
-
D
L
I
Y
T
Y
S
G
L
F
L
V
A
V
N
P
F
K
R
I
-
P
I
Y
T
Q
E
M
V
D
I
F
K
G
R
R
R
N
E
V
A
P
H
I
F
A
I
S
D
V
A
Y
R
S
M
L
D
D
R
Q
N
Q
S
L
L
I
T
G
E
S
G
A
G
K
T
E
N
T
K
K
V
I
Q
Y
L
-
A
S
V
A
G
R
------G---
V
L
E
Q
Q
I
L
Q
A
N
P
I
L
E
A
F
G
N
A
K
T
T
R
N
N
N
S
S
E
F
G
K
F
I
E
I
Q
F
N
S
A
G
F
I
S
G
A
S
I
Q
S
Y
L
L
E
K
S
R
V
V
F
Q
S
E
T
E
R
N
Y
H
I
F
Y
Q
L
L
A
G
A
T
-------
A
E
E
K
K
A
-
L
H
L
A
G
P
E
S
F
N
Y
L
-
N
-
Q
S
G
C
-
V
--
D
--
I
K
G
V
-
S
D
S
E
----------
E
F
K
I
T
R
Q
A
--
M
D
I
V
G
F
S
Q
E
E
Q
M
S
I
F
K
I
I
A
G
I
L
H
L
G
N
I
K
F
E
K
G
A
G
E
G
A
V
L
K
D
K
T
-----
A
L
N
A
A
S
T
V
F
G
-
V
N
P
S
V
L
E
K
A
L
M
E
P
R
I
L
A
-----
G
R
D
L
V
A
Q
H
L
N
V
E
K
S
S
S
S
R
D
A
L
V
K
A
L
Y
G
R
L
F
L
W
L
V
K
K
I
N
N
V
L
------
C
Q
E
R
K
A
Y
F
I
G
V
L
D
I
S
G
F
R
I
F
K
V
N
S
F
E
Q
L
C
I
N
Y
T
N
E
K
L
Q
Q
F
F
N
H
H
M
F
K
L
E
Q
E
E
Y
L
K
E
K
I
N
W
T
F
I
D
F
G
L
D
S
Q
A
T
I
D
L
I
D
G
R
Q
P
P
G
I
L
A
L
L
D
E
Q
S
V
F
P
N
A
T
D
N
T
L
I
T
----
K
L
H
S
H
F
--
S
K
K
NA
K
Y
E
--------
E
P
R
-----
F
S
K
T
E
----------
F
G
V
T
H
Y
A
G
Q
V
M
Y
E
I
Q
D
W
L
E
K
N
K
D
P
L
Q
Q
D
L
E
L
C
F
K
D
S
S
D
-
N
V
V
T
K
L
F
N
D
P
-----
N
I
A
-----------------
S
R
A
K
K
G
A
N
F
I
---------------
T
V
A
A
Q
Y
K
E
Q
L
A
S
L
M
A
T
L
E
T
T
N
P
H
F
V
R
C
I
I
P
N
N
K
Q
L
P
A
K
L
E
D
K
V
V
L
D
Q
L
R
C
N
G
V
L
E
G
I
R
I
T
R
K
G
F
P
N
R
I
I
Y
A
D
F
-------------------------
A
T
D
-
A
V
---------E-
Q
Y
R
F
G
I
T
K
I
F
F
R
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
30
PsiBlast_CBE
79.03
35%
-98
- C2 -
1D1A
1
MYS2_DICDI
A:
[89-747]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
D
M
S
E
L
S
Y
L
N
E
P
A
V
F
H
N
L
R
V
R
Y
N
Q
-
D
L
I
Y
T
Y
S
G
L
F
L
V
A
V
N
P
F
K
R
I
-
P
I
Y
T
Q
E
M
V
D
I
F
K
G
R
R
R
N
E
V
A
P
H
I
F
A
I
S
D
V
A
Y
R
S
M
L
D
D
R
Q
N
Q
S
L
L
I
T
G
E
S
G
A
G
K
T
E
N
T
K
K
V
I
Q
Y
L
-
A
S
V
A
G
R
---
N
Q
-G---
V
L
E
Q
Q
I
L
Q
A
N
P
I
L
E
A
F
G
N
A
K
T
T
R
N
N
N
S
S
R
F
G
K
F
I
E
I
Q
F
N
N
A
G
F
I
S
G
A
S
I
Q
S
Y
L
L
E
K
S
R
V
V
F
Q
S
E
T
E
R
N
Y
H
I
F
Y
Q
L
L
A
G
A
T
-------
A
E
E
K
K
A
-
L
H
L
A
G
P
E
S
F
N
Y
L
-
N
-
Q
S
G
C
-
V
--
D
--
I
K
G
V
-
S
D
S
E
----------
E
F
K
I
T
R
Q
A
--
M
D
I
V
G
F
S
Q
E
E
Q
M
S
I
F
K
I
I
A
G
I
L
H
L
G
N
I
K
F
E
K
G
A
G
E
G
A
V
L
K
D
K
T
-----
A
L
N
A
A
S
T
V
F
G
-
V
N
P
S
V
L
E
K
A
L
M
E
P
R
I
L
A
-----
G
R
D
L
V
A
Q
H
L
N
V
E
K
S
S
S
S
R
D
A
L
V
K
A
L
Y
G
R
L
F
L
W
L
V
K
K
I
N
N
V
L
------
C
Q
E
R
K
A
Y
F
I
G
V
L
D
I
S
G
F
E
I
F
K
V
N
S
F
E
Q
L
C
I
N
Y
T
N
E
K
L
Q
Q
F
F
N
H
H
M
F
K
L
E
Q
E
E
Y
L
K
E
K
I
N
W
----
F
G
L
D
S
Q
A
T
I
D
L
I
D
G
R
Q
P
P
G
I
L
A
L
L
D
E
Q
S
V
F
P
N
A
T
D
N
T
L
I
T
----
K
L
H
S
H
F
--
S
K
K
NA
K
Y
E
--------
E
P
R
-----
F
S
K
T
E
----------
F
G
V
T
H
Y
A
G
Q
V
M
Y
E
I
Q
D
W
L
E
K
N
K
D
P
L
Q
Q
D
L
E
L
C
F
K
D
S
S
D
-
N
V
V
T
K
L
F
N
D
P
-----
N
I
A
-----------------
S
R
A
-----
F
I
---------------
T
V
A
A
Q
Y
K
E
Q
L
A
S
L
M
A
T
L
E
T
T
N
P
H
F
V
R
C
I
I
P
N
N
K
Q
L
P
A
K
L
E
D
K
V
V
L
D
Q
L
R
C
N
G
V
L
E
G
I
R
I
T
R
K
G
F
P
N
R
I
I
Y
A
D
F
V
K
R
Y
--
Y
L
L
A
P
N
V
-
P
R
D
A
E
D
S
--
Q
K
A
T
D
-
A
V
L
K
H
L
N
I
--
D
PE
Q
Y
R
F
G
I
T
K
I
F
F
R
A
G
Q
L
A
R
I
E
E
A
R
E
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
28
PsiBlast_CBE
78.86
35%
-97
- C2 -
1LVK
1
MYS2_DICDI
A:
[89-747]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
D
M
S
E
L
S
Y
L
N
E
P
A
V
F
H
N
L
R
V
R
Y
N
Q
-
D
L
I
Y
T
Y
S
G
L
F
L
V
A
V
N
P
F
K
R
I
-
P
I
Y
T
Q
E
M
V
D
I
F
K
G
R
R
R
N
E
V
A
P
H
I
F
A
I
S
D
V
A
Y
R
S
M
L
D
D
R
Q
N
Q
S
L
L
I
T
G
E
S
G
A
G
K
T
E
N
T
K
K
V
I
Q
Y
L
-
A
S
V
A
G
R
---
N
Q
A
G---
V
L
E
Q
Q
I
L
Q
A
N
P
I
L
E
A
F
G
N
A
K
T
T
R
N
N
N
S
S
R
F
G
K
F
I
E
I
Q
F
N
N
A
G
F
I
S
G
A
S
I
Q
S
Y
L
L
E
K
S
R
V
V
F
Q
S
T
S
E
R
N
Y
H
I
F
Y
Q
L
L
A
G
A
T
-------
A
E
E
K
K
A
-
L
H
L
A
G
P
E
S
F
N
Y
L
-
N
-
Q
S
G
C
-
V
D
I
K
--
G
V
S
D
E
D
-------------
E
F
K
I
T
R
Q
A
--
M
D
I
V
G
F
S
Q
E
E
Q
M
S
I
F
K
I
I
A
G
I
L
H
L
G
N
I
K
F
E
K
G
A
G
E
G
A
V
L
K
D
K
T
-----
A
L
N
A
A
S
T
V
F
G
-
V
N
P
S
V
L
E
K
A
L
M
E
P
R
I
L
A
-----
G
R
D
L
V
A
Q
H
L
N
V
E
K
S
S
S
S
R
D
A
L
V
K
A
L
Y
G
R
L
F
L
W
L
V
K
K
I
N
N
V
L
------
C
S
E
R
K
A
Y
F
I
G
V
L
D
I
S
G
F
E
I
F
K
V
N
S
F
E
Q
L
C
I
N
Y
T
N
E
K
L
Q
Q
F
F
N
H
H
M
F
K
V
E
Q
E
K
Y
L
K
E
K
I
N
-------L
D
S
Q
A
T
I
D
L
I
D
G
R
Q
P
P
G
I
L
A
L
L
D
E
Q
S
V
F
P
N
A
T
D
N
T
L
I
T
----
K
L
H
S
H
F
--
S
K
K
NA
K
Y
E
--------
E
P
R
-----
F
S
K
T
E
----------
F
G
V
T
H
Y
A
G
Q
V
M
Y
E
I
Q
D
W
L
E
K
N
K
D
P
L
Q
Q
D
L
E
L
C
F
K
D
S
S
D
-
N
V
V
T
K
L
F
N
D
P
-----
N
I
A
-----------------
S
R
A
-----
F
L
---------------
T
V
A
A
Q
Y
K
E
Q
L
A
S
L
M
A
T
L
E
T
T
N
P
H
F
V
R
C
I
I
P
N
N
K
Q
L
P
A
K
L
E
D
K
V
V
L
D
Q
L
R
C
N
G
V
L
E
G
I
R
I
T
R
K
G
F
P
N
R
I
I
Y
A
D
F
V
K
R
Y
--
Y
D
L
A
P
N
V
-
P
R
D
A
E
D
S
--
Q
K
A
T
D
-
A
V
L
K
H
L
N
I
--
D
PE
Q
F
R
F
G
I
T
K
I
F
F
R
A
G
Q
L
A
R
I
E
E
A
R
E
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
34
PsiBlast_CBE
78.82
35%
-96
- C2 -
1W9L
5
MYS2_DICDI
A:
[89-747]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
D
M
S
E
L
S
Y
L
N
E
P
A
V
F
H
N
L
R
V
R
Y
N
Q
-
D
L
I
Y
T
Y
S
G
L
F
L
V
A
V
N
P
F
K
R
I
-
P
I
Y
T
Q
E
M
V
D
I
F
K
G
R
R
R
N
E
V
A
P
H
I
F
A
I
S
D
V
A
Y
R
S
M
L
D
D
R
Q
N
Q
S
L
L
I
T
G
E
S
G
A
G
K
T
E
N
T
K
K
V
I
Q
Y
L
-
A
S
V
A
G
R
----------
V
L
E
Q
Q
I
L
Q
A
N
P
I
L
E
A
F
G
N
A
K
T
T
R
N
N
N
S
S
R
F
G
K
F
I
E
I
Q
F
N
S
A
G
F
I
S
G
A
S
I
Q
S
Y
L
L
E
K
S
R
V
V
F
Q
S
E
T
E
R
N
Y
H
I
F
Y
Q
L
L
A
G
A
T
-------
A
E
E
K
K
A
-
L
H
L
A
G
P
E
S
F
N
Y
L
-
N
-
Q
S
G
C
-
V
--
D
--
I
K
G
V
-
S
D
S
E
----------
E
F
K
I
T
R
Q
A
--
M
D
I
V
G
F
S
Q
E
E
Q
M
S
I
F
K
I
I
A
G
I
L
H
L
G
N
I
K
F
E
K
G
A
G
E
G
A
V
L
K
D
K
T
-----
A
L
N
A
A
S
T
V
F
G
-
V
N
P
S
V
L
E
K
A
L
M
E
P
R
I
L
A
-----
G
R
D
L
V
A
Q
H
L
N
V
E
K
S
S
S
S
R
D
A
L
V
K
A
L
Y
G
R
L
F
L
W
L
V
K
K
I
N
N
V
L
------
C
Q
E
R
K
A
Y
F
I
G
V
L
D
I
E
G
F
E
I
F
K
V
N
S
F
E
Q
L
C
I
N
Y
T
N
E
K
L
Q
Q
F
F
N
H
H
M
F
K
L
E
Q
E
E
Y
L
K
E
K
I
N
W
T
F
I
D
F
G
L
D
S
Q
A
T
I
D
L
I
D
G
R
Q
P
P
G
I
L
A
L
L
D
E
Q
S
V
F
P
N
A
T
D
N
T
L
I
T
----
K
L
H
S
H
F
--
S
K
K
NA
K
Y
E
--------
E
P
R
-----
F
S
K
T
E
----------
F
G
V
T
H
Y
A
G
Q
V
M
Y
E
I
Q
D
W
L
E
K
N
K
D
P
L
Q
Q
D
L
E
L
C
F
K
D
S
S
D
-
N
V
V
T
K
L
F
N
D
P
-----
N
I
A
-----------------
S
R
A
K
K
G
A
N
F
I
---------------
T
V
A
A
Q
Y
K
E
Q
L
A
S
L
M
A
T
L
E
T
T
N
P
H
F
V
R
C
I
I
P
N
N
K
Q
L
P
A
K
L
E
D
K
V
V
L
D
Q
L
R
C
N
G
V
L
E
G
I
R
I
T
R
K
G
F
P
N
R
I
I
Y
A
D
F
V
K
R
Y
------------
D
A
E
D
S
--
Q
K
A
T
D
-
A
V
L
-------
D
PE
Q
Y
R
F
G
I
T
K
I
F
F
R
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
18
PsiBlast_PDB
78.77
35%
-95
- C2 -
4AE3
7
MYS2_DICDI
A:
[88-746]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
D
M
S
E
L
S
Y
L
N
E
P
A
V
F
H
N
L
R
V
R
Y
N
Q
-
D
L
I
Y
T
Y
S
G
L
F
L
V
A
V
N
P
F
K
R
I
-
P
I
Y
T
Q
E
M
V
D
I
F
K
G
R
R
R
N
E
V
A
P
H
I
F
A
I
S
D
V
A
Y
R
S
M
L
D
D
R
Q
N
Q
S
L
L
I
T
G
E
S
G
A
G
K
T
E
N
T
K
K
V
I
Q
Y
L
-
A
S
V
A
G
R
------SG--
V
L
E
Q
Q
I
L
Q
A
N
P
I
L
E
A
F
G
N
A
K
T
T
R
N
N
N
S
S
R
F
G
K
F
I
E
I
Q
F
N
S
A
G
F
I
S
G
A
S
I
Q
S
Y
L
L
E
K
S
R
V
V
F
Q
S
E
T
E
R
N
Y
H
I
F
Y
Q
L
L
A
G
A
T
-------
A
E
E
K
K
A
-
L
H
L
A
G
P
E
S
F
N
Y
L
-
N
-
Q
S
G
C
-
V
--
D
--
I
K
G
V
-
S
D
S
E
----------
E
F
K
I
T
R
Q
A
--
M
D
I
V
G
F
S
Q
E
E
Q
M
S
I
F
K
I
I
A
G
I
L
H
L
G
N
I
K
F
E
K
G
A
G
E
G
A
V
L
K
D
K
T
-----
A
L
N
A
A
S
T
V
F
G
-
V
N
P
S
V
L
E
K
A
L
M
E
P
R
I
L
A
-----
G
R
D
L
V
A
Q
H
L
N
V
E
K
S
S
S
S
R
D
A
L
V
K
A
L
Y
G
R
L
F
L
W
L
V
K
K
I
N
N
V
L
------
C
Q
E
R
K
A
Y
F
I
G
V
L
D
I
S
G
F
E
I
F
K
V
N
S
F
E
Q
L
C
I
N
Y
T
N
E
K
L
Q
Q
F
F
N
H
H
M
F
K
L
E
Q
E
E
Y
L
K
E
K
I
N
W
T
F
I
D
F
G
L
D
S
Q
A
T
I
D
L
I
D
G
R
Q
P
P
G
I
L
A
L
L
D
E
Q
S
V
F
P
N
A
T
D
N
T
L
I
T
----
K
L
H
S
H
F
--
S
K
K
NA
K
Y
E
--------
E
P
R
-----
F
S
K
T
E
----------
F
G
V
T
H
Y
A
G
Q
V
M
Y
E
I
Q
D
W
L
E
K
N
K
D
P
L
Q
Q
D
L
E
L
C
F
K
D
S
S
D
-
N
V
V
T
K
L
F
N
D
P
-----
N
I
A
-----------------
S
R
A
K
K
G
A
N
F
I
---------------
T
V
A
A
Q
Y
K
E
Q
L
A
S
L
M
A
T
L
E
T
T
N
P
H
F
V
R
C
I
I
P
N
N
K
Q
L
P
A
K
L
E
D
K
V
V
L
D
Q
L
R
C
N
G
V
L
E
G
I
R
I
T
R
K
G
F
P
N
R
I
I
Y
A
D
F
V
K
R
Y
--
Y
L
L
A
P
N
V
-
P
R
D
A
E
D
S
--
Q
K
A
T
D
-
A
V
L
K
H
L
N
I
--
D
PE
Q
Y
R
F
G
I
T
K
I
F
F
R
A
G
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
17
PsiBlast_PDB
78.57
35%
-93
- C2 -
2XEL
2
MYS2_DICDI
A:
[88-746]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
D
M
S
E
L
S
Y
L
N
E
P
A
V
F
H
N
L
R
V
R
Y
N
Q
-
D
L
I
Y
T
Y
S
G
L
F
L
V
A
V
N
P
F
K
R
I
-
P
I
Y
T
Q
E
M
V
D
I
F
K
G
R
R
R
N
E
V
A
P
H
I
F
A
I
S
D
V
A
Y
R
S
M
L
D
D
R
Q
N
Q
S
L
L
I
T
G
E
S
G
A
G
K
T
E
N
T
K
K
V
I
Q
Y
L
-
A
S
V
A
G
R
---
N
Q
A
NGSG
V
L
E
Q
Q
I
L
Q
A
N
P
I
L
E
A
F
G
N
A
K
T
T
R
N
N
N
S
S
R
F
G
K
F
I
E
I
Q
F
N
S
A
G
F
I
S
G
A
S
I
Q
S
Y
L
L
E
K
S
R
V
V
F
Q
S
E
T
E
R
N
Y
H
I
F
Y
Q
L
L
A
G
A
T
-------
A
E
E
K
K
A
-
L
H
L
A
G
P
E
S
F
N
Y
L
-
N
-
Q
S
G
C
-
V
--
D
--
I
K
G
V
-
S
D
S
E
----------
E
F
K
I
T
R
Q
A
--
M
D
I
V
G
F
S
Q
E
E
Q
M
S
I
F
K
I
I
A
G
I
L
H
L
G
N
I
K
F
E
K
G
A
G
E
G
A
V
L
K
D
K
T
-----
A
L
N
A
A
S
T
V
F
G
-
V
N
P
S
V
L
E
K
A
L
M
E
P
R
I
L
A
-----
G
R
D
L
V
A
Q
H
L
N
V
E
K
S
S
S
S
R
D
A
L
V
K
A
L
Y
G
R
L
F
L
W
L
V
K
K
I
N
N
V
L
------
C
Q
E
R
K
A
Y
F
I
G
V
L
D
I
S
G
F
E
I
F
K
V
N
S
F
E
Q
L
C
I
N
Y
T
N
E
K
L
Q
Q
F
F
N
H
H
M
F
K
L
E
Q
E
E
Y
L
K
E
K
I
N
W
T
F
I
D
F
G
L
D
S
Q
A
T
I
D
L
I
D
G
R
Q
P
P
G
I
L
A
L
L
D
E
Q
S
V
F
P
N
A
T
D
N
T
L
I
T
----
K
L
H
S
H
F
--
S
K
K
NA
K
Y
E
--------
E
P
R
-----
F
S
K
T
E
----------
F
G
V
T
H
Y
A
G
Q
V
M
Y
E
I
Q
D
W
L
E
K
N
K
D
P
L
Q
Q
D
L
E
L
C
F
K
D
S
S
D
-
N
V
V
T
K
L
F
N
D
P
-----
N
I
A
-----------------
S
R
A
K
K
G
A
N
F
I
---------------
T
V
A
A
Q
Y
K
E
Q
L
A
S
L
M
A
T
L
E
T
T
N
P
H
F
V
R
C
I
I
P
N
N
K
Q
L
P
A
K
L
E
D
K
V
V
L
D
Q
L
R
C
N
G
V
L
E
G
I
R
I
T
R
K
G
F
P
N
R
I
I
Y
A
D
F
V
K
R
Y
--
Y
L
L
A
P
N
V
-
P
R
D
A
E
D
S
--
Q
K
A
T
D
-
A
V
L
K
H
L
N
I
--
D
PE
Q
Y
R
F
G
I
T
K
I
F
F
R
A
G
Q
L
A
R
I
E
E
A
R
E
Q
R
L
-
E
S
N
E
-
P
P
M
D
F
D
D
D
I
P
F
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
27
PsiBlast_CBE
78.47
35%
-98
- C2 -
1MMN
1
MYS2_DICDI
A:
[89-747]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
D
M
S
E
L
S
Y
L
N
E
P
A
V
F
H
N
L
R
V
R
Y
N
Q
-
D
L
I
Y
T
Y
S
G
L
F
L
V
A
V
N
P
F
K
R
I
-
P
I
Y
T
Q
E
M
V
D
I
F
K
G
R
R
R
N
E
V
A
P
H
I
F
A
I
S
D
V
A
Y
R
S
M
L
D
D
R
Q
N
Q
S
L
L
I
T
G
E
S
G
A
G
K
T
E
N
T
K
K
V
I
Q
Y
L
-
A
S
V
A
G
-------G---
V
L
E
Q
Q
I
L
Q
A
N
P
I
L
E
A
F
G
N
A
K
T
T
R
N
N
N
S
S
R
F
G
K
F
I
E
I
Q
F
N
N
A
G
F
I
S
G
A
S
I
Q
S
Y
L
L
E
K
S
R
V
V
F
Q
S
T
T
E
R
N
Y
H
I
F
Y
Q
L
L
A
G
A
T
-------
A
E
E
K
K
A
-
L
H
L
A
G
P
E
S
F
N
Y
L
-
N
-
Q
S
G
C
-
V
D
I
K
--
G
V
S
D
E
---
E
----------
E
F
K
I
T
R
Q
A
--
M
D
I
V
G
F
S
Q
E
E
Q
M
S
I
F
K
I
I
A
G
I
L
H
L
G
N
I
K
F
E
K
G
A
G
E
G
A
V
L
K
D
K
T
-----
A
L
N
A
A
S
T
V
F
G
-
V
N
P
S
V
L
E
K
A
L
M
E
P
R
I
L
A
-----
G
R
D
L
V
A
Q
H
L
N
V
E
K
S
S
S
S
R
D
A
L
V
K
A
L
Y
G
R
L
F
L
W
L
V
K
K
I
N
N
V
L
------
C
S
E
R
K
A
Y
F
I
G
V
L
D
I
S
G
F
E
I
F
K
V
N
S
F
E
Q
L
C
I
N
Y
T
N
E
K
L
Q
Q
F
F
N
H
H
M
F
K
V
E
Q
E
E
Y
L
K
E
K
I
---------
D
S
Q
A
T
I
D
L
I
D
G
R
Q
P
P
G
I
L
A
L
L
D
E
Q
S
V
F
P
N
A
T
D
N
T
L
I
T
----
K
L
H
S
H
F
--
S
K
K
NA
K
Y
E
--------
E
P
R
-----
F
S
K
T
E
----------
F
G
V
T
H
Y
A
G
Q
V
M
Y
E
I
Q
D
W
L
E
K
N
K
D
P
L
Q
Q
D
L
E
L
C
F
K
D
S
S
D
-
N
V
V
T
K
L
F
N
D
P
-----
N
I
A
-----------------
S
R
A
-----
F
I
---------------
T
V
A
A
Q
Y
K
E
Q
L
A
S
L
M
A
T
L
E
T
T
N
P
H
F
V
R
C
I
I
P
N
N
K
Q
L
P
A
K
L
E
D
K
V
V
L
D
Q
L
R
C
N
G
V
L
E
G
I
R
I
T
R
K
G
F
P
N
R
I
I
Y
A
D
F
V
K
R
Y
--
Y
D
L
A
P
N
V
-
P
R
D
A
E
D
S
--
Q
K
A
T
D
-
A
V
L
K
H
L
N
I
--
D
PE
Q
F
R
F
G
I
T
K
I
F
F
R
A
G
Q
L
A
R
I
E
E
A
R
E
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
13
PsiBlast_PDB
78.39
35%
-95
- C2 -
3MNQ
5
MYS2_DICDI
A:
[100-758]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
D
M
S
E
L
S
Y
L
N
E
P
A
V
F
H
N
L
R
V
R
Y
N
Q
-
D
L
I
Y
T
Y
S
G
L
F
L
V
A
V
N
P
F
K
R
I
-
P
I
Y
T
Q
E
M
V
D
I
F
K
G
R
R
R
N
E
V
A
P
H
I
F
A
I
S
D
V
A
Y
R
S
M
L
D
D
R
Q
N
Q
S
L
L
I
T
G
E
S
G
A
G
K
T
E
N
T
K
K
V
I
Q
Y
L
-
A
S
V
A
G
R
---
N
Q
A
NGSG
V
L
E
Q
Q
I
L
Q
A
N
P
I
L
E
A
F
G
N
A
K
T
T
R
N
N
N
S
S
R
F
G
K
F
I
E
I
Q
F
N
S
A
G
F
I
S
G
A
S
I
Q
S
Y
L
L
E
K
S
R
V
V
F
Q
S
E
T
E
R
N
Y
H
I
F
Y
Q
L
L
A
G
A
T
-------
A
E
E
K
K
A
-
L
H
L
A
G
P
E
S
F
N
Y
L
-
N
-
Q
S
G
C
-
V
--
D
--
I
K
G
V
-
S
D
S
E
----------
E
F
K
I
T
R
Q
A
--
M
D
I
V
G
F
S
Q
E
E
Q
M
S
I
F
K
I
I
A
G
I
L
H
L
G
N
I
K
F
E
K
G
A
G
E
G
A
V
L
K
D
K
T
-----
A
L
N
A
A
S
T
V
F
G
-
V
N
P
S
V
L
E
K
A
L
M
E
P
R
I
L
A
-----
G
R
D
L
V
A
Q
H
L
N
V
E
K
S
S
S
S
R
D
A
L
V
K
A
L
Y
G
R
L
F
L
W
L
V
K
K
I
N
N
V
L
------
C
Q
E
R
K
A
Y
F
I
G
V
L
D
I
S
G
F
E
I
F
K
V
N
S
F
E
Q
L
C
I
N
Y
T
N
E
K
L
Q
Q
F
F
N
H
H
M
F
K
L
E
Q
E
E
Y
L
K
E
K
I
N
W
T
F
I
D
F
G
L
D
S
Q
A
T
I
D
L
I
D
G
R
Q
P
P
G
I
L
A
L
L
D
E
Q
S
V
F
P
N
A
T
D
N
T
L
I
T
----
K
L
H
S
H
F
--
S
K
K
NA
K
Y
E
--------
E
P
R
-----
F
S
K
T
E
----------
F
G
V
T
H
Y
A
G
Q
V
M
Y
E
I
Q
D
W
L
E
K
N
K
D
P
L
Q
Q
D
L
E
L
C
F
K
D
S
S
D
-
N
V
V
T
K
L
F
N
D
P
-----
N
I
A
-----------------
S
R
A
K
K
G
A
N
F
I
---------------
T
V
A
A
Q
Y
K
E
Q
L
A
S
L
M
A
T
L
E
T
T
N
P
H
F
V
R
C
I
I
P
N
N
K
Q
L
P
A
K
L
E
D
K
V
V
L
D
Q
L
R
C
N
G
V
L
E
G
I
R
I
T
R
K
G
F
P
N
R
I
I
Y
A
D
F
V
K
R
Y
-----------
R
D
A
E
D
S
--
Q
K
A
T
D
-
A
---------
D
PE
Q
Y
R
F
G
I
T
K
I
F
F
R
A
G
Q
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
38
PsiBlast_CBE
78.14
35%
-95
- C2 -
3MYH
2
MYS2_DICDI
X:
[89-747]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
D
M
S
E
L
S
Y
L
N
E
P
A
V
F
H
N
L
R
V
R
Y
N
Q
-
D
L
I
Y
T
Y
S
G
L
F
L
V
A
V
N
P
F
K
R
I
-
P
I
Y
T
Q
E
M
V
D
I
F
K
G
R
R
R
N
E
V
A
P
H
I
F
A
I
S
D
V
A
Y
R
S
M
L
D
D
R
Q
N
Q
S
L
L
I
T
G
E
S
G
A
G
K
T
E
N
T
K
K
V
I
Q
Y
L
-
A
S
V
A
G
R
------G---
V
L
E
Q
Q
I
L
Q
A
N
P
I
L
E
A
F
G
N
A
K
T
T
R
N
N
N
A
S
R
F
G
K
F
I
E
I
Q
F
N
S
A
G
F
I
S
G
A
S
I
Q
S
Y
L
L
E
K
S
R
V
V
F
Q
S
E
T
E
R
N
Y
H
I
F
Y
Q
L
L
A
G
A
T
-------
A
E
E
K
K
A
-
L
H
L
A
G
P
E
S
F
N
Y
L
-
N
-
Q
S
G
C
-
V
--
D
--
I
K
G
V
-
S
D
S
E
----------
E
F
K
I
T
R
Q
A
--
M
D
I
V
G
F
S
Q
E
E
Q
M
S
I
F
K
I
I
A
G
I
L
H
L
G
N
I
K
F
E
K
G
A
G
E
G
A
V
L
K
D
K
T
-----
A
L
N
A
A
S
T
V
F
G
-
V
N
P
S
V
L
E
K
A
L
M
E
P
R
I
L
A
-----
G
R
D
L
V
A
Q
H
L
N
V
E
K
S
S
S
S
R
D
A
L
V
K
A
L
Y
G
R
L
F
L
W
L
V
K
K
I
N
N
V
L
------
C
Q
E
R
K
A
Y
F
I
G
V
L
D
I
S
G
F
E
I
F
K
V
N
S
F
E
Q
L
C
I
N
Y
T
N
E
K
L
Q
Q
F
F
N
H
H
M
F
K
L
E
Q
E
E
Y
L
K
E
K
I
N
W
T
F
I
D
F
G
L
D
S
Q
A
T
I
D
L
I
D
G
R
Q
P
P
G
I
L
A
L
L
D
E
Q
S
V
F
P
N
A
T
D
N
T
L
I
T
----
K
L
H
S
H
F
--
S
K
K
NA
K
Y
E
--------
E
P
R
-----
F
S
K
T
E
----------
F
G
V
T
H
Y
A
G
Q
V
M
Y
E
I
Q
D
W
L
E
K
N
K
D
P
L
Q
Q
D
L
E
L
C
F
K
D
S
S
D
-
N
V
V
T
K
L
F
N
D
P
-----
N
I
A
-----------------
S
R
A
K
K
G
A
N
F
I
---------------
T
V
A
A
Q
Y
K
E
Q
L
A
S
L
M
A
T
L
E
T
T
N
P
H
F
V
R
C
I
I
P
N
N
K
Q
L
P
A
K
L
E
D
K
V
V
L
D
Q
L
R
C
N
G
V
L
E
G
I
R
I
T
R
K
G
F
P
N
R
I
I
Y
A
D
----------------------------------------
D
PE
Q
Y
R
F
G
I
T
K
I
F
F
R
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
37
PsiBlast_CBE
78.08
35%
-94
- C2 -
3MYK
2
MYS2_DICDI
X:
[89-747]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
D
M
S
E
L
S
Y
L
N
E
P
A
V
F
H
N
L
R
V
R
Y
N
Q
-
D
L
I
Y
T
Y
S
G
L
F
L
V
A
V
N
P
F
K
R
I
-
P
I
Y
T
Q
E
M
V
D
I
F
K
G
R
R
R
N
E
V
A
P
H
I
F
A
I
S
D
V
A
Y
R
S
M
L
D
D
R
Q
N
Q
S
L
L
I
T
G
E
S
G
A
G
K
T
E
N
T
K
K
V
I
Q
Y
L
-
A
S
V
A
G
R
---
N
--SG--
V
L
E
Q
Q
I
L
Q
A
N
P
I
L
E
A
F
G
N
A
K
T
T
R
N
N
N
A
S
R
F
G
K
F
I
E
I
Q
F
N
S
A
G
F
I
S
G
A
S
I
Q
S
Y
L
L
E
K
S
R
V
V
F
Q
S
E
T
E
R
N
Y
H
I
F
Y
Q
L
L
A
G
A
T
-------
A
E
E
K
K
A
-
L
H
L
A
G
P
E
S
F
N
Y
L
-
N
-
Q
S
G
C
-
V
--
D
--
I
K
G
V
-
S
D
S
E
----------
E
F
K
I
T
R
Q
A
--
M
D
I
V
G
F
S
Q
E
E
Q
M
S
I
F
K
I
I
A
G
I
L
H
L
G
N
I
K
F
E
K
G
A
G
E
G
A
V
L
K
D
K
T
-----
A
L
N
A
A
S
T
V
F
G
-
V
N
P
S
V
L
E
K
A
L
M
E
P
R
I
L
A
-----
G
R
D
L
V
A
Q
H
L
N
V
E
K
S
S
S
S
R
D
A
L
V
K
A
L
Y
G
R
L
F
L
W
L
V
K
K
I
N
N
V
L
------
C
Q
E
R
K
A
Y
F
I
G
V
L
D
I
S
G
F
E
I
F
K
V
N
S
F
E
Q
L
C
I
N
Y
T
N
E
K
L
Q
Q
F
F
N
H
H
M
F
K
L
E
Q
E
E
Y
L
K
E
K
I
N
W
T
F
I
D
F
G
L
D
S
Q
A
T
I
D
L
I
D
G
R
Q
P
P
G
I
L
A
L
L
D
E
Q
S
V
F
P
N
A
T
D
N
T
L
I
T
----
K
L
H
S
H
F
--
S
K
K
NA
K
Y
E
--------
E
P
R
-----
F
S
K
T
E
----------
F
G
V
T
H
Y
A
G
Q
V
M
Y
E
I
Q
D
W
L
E
K
N
K
D
P
L
Q
Q
D
L
E
L
C
F
K
D
S
S
D
-
N
V
V
T
K
L
F
N
D
P
-----
N
I
A
-----------------
S
R
A
K
K
G
A
N
F
I
---------------
T
V
A
A
Q
Y
K
E
Q
L
A
S
L
M
A
T
L
E
T
T
N
P
H
F
V
R
C
I
I
P
N
N
K
Q
L
P
A
K
L
E
D
K
V
V
L
D
Q
L
R
C
N
G
V
L
E
G
I
R
I
T
R
K
G
F
P
N
R
I
I
----------------------------------------------
Q
Y
R
F
G
I
T
K
I
F
F
R
A
G
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
7
PsiBlast_PDB
77.98
35%
-96
- C2 -
1W9I
16
MYS2_DICDI
A:
[89-747]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
D
M
S
E
L
S
Y
L
N
E
P
A
V
F
H
N
L
R
V
R
Y
N
Q
-
D
L
I
Y
T
Y
S
G
L
F
L
V
A
V
N
P
F
K
R
I
-
P
I
Y
T
Q
E
M
V
D
I
F
K
G
R
R
R
N
E
V
A
P
H
I
F
A
I
S
D
V
A
Y
R
S
M
L
D
D
R
Q
N
Q
S
L
L
I
T
G
E
S
G
A
G
K
T
E
N
T
K
K
V
I
Q
Y
L
-
A
S
V
A
G
R
------G---
V
L
E
Q
Q
I
L
Q
A
N
P
I
L
E
A
F
G
N
A
K
T
T
R
N
N
N
S
S
R
F
G
K
F
I
E
I
Q
F
N
S
A
G
F
I
S
G
A
S
I
Q
S
Y
L
L
E
K
S
R
V
V
F
Q
S
E
T
E
R
N
Y
H
I
F
Y
Q
L
L
A
G
A
T
-------
A
E
E
K
K
A
-
L
H
L
A
G
P
E
S
F
N
Y
L
-
N
-
Q
S
G
C
-
V
--
D
--
I
K
G
V
-
S
D
S
E
----------
E
F
K
I
T
R
Q
A
--
M
D
I
V
G
F
S
Q
E
E
Q
M
S
I
F
K
I
I
A
G
I
L
H
L
G
N
I
K
F
E
K
G
A
G
E
G
A
V
L
K
D
K
T
-----
A
L
N
A
A
S
T
V
F
G
-
V
N
P
S
V
L
E
K
A
L
M
E
P
R
I
L
A
-----
G
R
D
L
V
A
Q
H
L
N
V
E
K
S
S
S
S
R
D
A
L
V
K
A
L
Y
G
R
L
F
L
W
L
V
K
K
I
N
N
V
L
------
C
Q
E
R
K
A
Y
F
I
G
V
L
D
I
Y
G
F
E
I
F
K
V
N
S
F
E
Q
L
C
I
N
Y
T
N
E
K
L
Q
Q
F
F
N
H
H
M
F
K
L
E
Q
E
E
Y
L
K
E
K
I
N
W
T
F
I
D
F
G
L
D
S
Q
A
T
I
D
L
I
D
G
R
Q
P
P
G
I
L
A
L
L
D
E
Q
S
V
F
P
N
A
T
D
N
T
L
I
T
----
K
L
H
S
H
F
--
S
K
K
NA
K
Y
E
--------
E
P
R
-----
F
S
K
T
E
----------
F
G
V
T
H
Y
A
G
Q
V
M
Y
E
I
Q
D
W
L
E
K
N
K
D
P
L
Q
Q
D
L
E
L
C
F
K
D
S
S
D
-
N
V
V
T
K
L
F
N
D
P
-----
N
I
A
-----------------
S
R
A
K
K
G
A
N
F
I
---------------
T
V
A
A
Q
Y
K
E
Q
L
A
S
L
M
A
T
L
E
T
T
N
P
H
F
V
R
C
I
I
P
N
N
K
Q
L
P
A
K
L
E
D
K
V
V
L
D
Q
L
R
C
N
G
V
L
E
G
I
R
I
T
R
K
G
F
P
N
R
I
I
Y
A
D
-------------------------------------------
Q
F
R
F
G
I
T
K
I
F
F
R
A
G
Q
L
A
R
I
E
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
63
PsiBlast_CBE
77.81
33%
-95
- C2 -
1B7T
1
MYS_ARGIR
A:
[86-825]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
D
M
A
N
M
T
Y
L
N
E
A
S
V
L
Y
N
L
R
S
R
Y
T
S
-
G
L
I
Y
T
Y
S
G
L
F
C
I
A
V
N
P
Y
R
R
L
-
P
I
Y
T
D
S
V
I
A
K
Y
R
G
K
R
K
T
E
I
P
P
H
L
F
S
V
A
D
N
A
Y
Q
N
M
V
T
D
R
E
N
Q
S
C
L
I
T
G
E
S
G
A
G
K
T
E
N
T
K
K
V
I
M
Y
L
-
A
K
V
A
C
A
------EG--
S
L
E
D
Q
I
I
Q
A
N
P
V
L
E
A
Y
G
N
A
K
T
T
R
N
N
N
S
S
R
F
G
K
F
I
R
I
H
F
G
P
T
G
K
I
A
G
A
D
I
E
T
Y
L
L
E
K
S
R
V
T
Y
Q
Q
S
A
E
R
N
Y
H
I
F
Y
Q
I
C
S
--
N
-------
A
I
P
E
L
N
D
V
M
L
V
T
P
D
S
G
L
Y
S
F
I
-
N
Q
G
C
-
L
T
V
D
N-
I
D
D
V
E
--------------
E
F
K
L
C
D
E
A
--
F
D
I
L
G
F
T
K
E
E
K
Q
S
M
F
K
C
T
A
S
I
L
H
M
G
E
M
K
F
K
------
Q
A
E
S
D
G
T
-
A
E
A
E
K
V
----
A
F
L
C
G
I
N
A
G
D
L
L
K
A
L
L
K
P
K
V
------------
T
K
G
Q
N
M
N
Q
V
V
N
S
V
G
A
L
A
K
S
L
Y
D
R
M
F
N
W
L
V
R
R
V
N
K
T
L
D
-----
T
K
A
K
R
N
Y
Y
I
G
V
L
D
I
A
G
F
E
I
F
D
F
N
S
F
E
Q
L
C
I
N
Y
T
N
E
R
L
Q
Q
F
F
N
H
H
M
F
I
L
E
Q
E
E
Y
K
K
E
G
I
A
W
E
F
I
D
F
G
-
M
D
L
Q
M
C
I
D
L
I
-
E
K
P
M
G
I
L
S
I
L
E
E
E
C
M
F
P
K
A
D
D
K
S
F
Q
D
----
K
L
Y
Q
N
H
--
M
G
K
--
N
R
M
FTK
P
G
K
P
T
R
P
N
-----
Q
G
P
A
H
----------
F
E
L
H
H
Y
A
G
N
V
P
Y
S
I
T
G
W
L
E
K
N
K
D
P
I
N
E
N
V
V
A
L
L
G
A
S
K
E
-
P
L
V
A
E
L
F
K
A
--------------------------------------------------
Q
T
I
S
A
V
H
R
E
S
L
N
K
L
M
K
N
L
Y
S
T
H
P
H
F
V
R
C
I
I
P
N
E
L
K
Q
P
G
L
V
D
A
E
L
V
L
H
Q
L
Q
C
N
G
--------
R
K
G
F
P
S
R
L
I
Y
S
E
F
K
Q
R
Y
--
S
I
L
A
P
N
A
I
P
----
D
G
--
K
T
V
S
E
-
K
I
L
A
G
L
Q
M
--
D
PA
E
Y
R
L
G
T
T
K
V
F
F
K
A
G
V
L
G
N
L
E
E
M
R
D
E
R
L
-
S
K
I
I
S
M
F
Q
A
H
I
R
G
Y
L
I
R
K
A
Y
K
K
L
Q
D
Q
R
-
I
G
L
S
V
I
Q
---
R
N
I
---
R
K
W
L
V
L
R
N
W
Q
W
W
K
L
Y
S
K
V
K
P
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
12
PsiBlast_PDB
77.29
35%
-93
- C2 -
1VOM
1
MYS2_DICDI
A:
[89-747]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
D
M
S
E
L
S
Y
L
N
E
P
A
V
F
H
N
L
R
V
R
Y
N
Q
-
D
L
I
Y
T
Y
S
G
L
F
L
V
A
V
N
P
F
K
R
I
-
P
I
Y
T
Q
E
M
V
D
I
F
K
G
R
R
R
N
E
V
A
P
H
I
F
A
I
S
D
V
A
Y
R
S
M
L
D
D
R
Q
N
Q
S
L
L
I
T
G
E
S
G
A
G
K
T
E
N
T
K
K
V
I
Q
Y
L
-
A
S
V
A
G
R
---
N
Q
-G---
V
L
E
Q
Q
I
L
Q
A
N
P
I
L
E
A
F
G
N
A
K
T
T
R
N
N
N
S
S
R
F
G
K
F
I
E
I
Q
F
N
N
A
G
F
I
S
G
A
S
I
Q
S
Y
L
L
E
K
S
R
V
V
F
Q
S
E
T
E
R
N
Y
H
I
F
Y
Q
L
L
A
G
A
T
-------
A
E
E
K
K
A
-
L
H
L
A
G
P
E
S
F
N
Y
L
-
N
-
Q
S
G
C
-
V
D
I
K
--
G
V
S
D
E
D
-------------
E
F
K
I
T
R
Q
A
--
M
D
I
V
G
F
S
Q
E
E
Q
M
S
I
F
K
I
I
A
G
I
L
H
L
G
N
I
K
F
E
K
G
A
G
E
G
A
V
L
K
D
K
T
-----
A
L
N
A
A
S
T
V
F
G
-
V
N
P
S
V
L
E
K
A
L
M
E
P
R
I
L
A
-----
G
R
D
L
V
A
Q
H
L
N
V
E
K
S
S
S
S
R
D
A
L
V
K
A
L
Y
G
R
L
F
L
W
L
V
K
K
I
N
N
V
L
------
C
S
E
R
A
A
Y
F
I
G
V
L
D
I
S
G
F
E
I
F
K
V
N
S
F
E
Q
L
C
I
N
Y
T
N
E
K
L
Q
Q
F
F
N
H
H
M
F
K
V
E
Q
E
E
Y
L
K
E
K
I
N
W
T
F
I
D
F
G
L
D
S
Q
A
T
I
D
L
I
D
G
R
Q
P
P
G
I
L
A
L
L
D
E
Q
S
V
F
P
N
A
T
D
N
T
L
I
T
----
K
L
H
S
H
F
--
S
K
K
NA
K
Y
E
--------
E
P
R
-----
F
S
K
T
E
----------
F
G
V
T
H
Y
A
G
Q
V
M
Y
E
I
Q
D
W
L
E
K
N
K
D
P
L
Q
Q
D
L
E
L
C
F
K
D
S
S
D
-
N
V
V
T
K
L
F
N
D
P
-----
N
I
A
-----------------
S
R
A
K
K
G
A
N
F
I
---------------
T
V
A
A
Q
Y
K
E
Q
L
A
S
L
M
A
T
L
E
T
T
N
P
H
F
V
R
C
I
I
P
N
N
K
Q
L
P
A
K
L
E
D
K
V
V
L
D
Q
L
R
C
N
G
V
L
E
G
I
R
I
T
R
K
G
F
P
N
R
I
I
Y
A
D
F
V
K
R
Y
--
Y
L
L
A
P
-
V
-
P
R
D
------
Q
K
A
T
--------
N
I
--
D
PE
Q
Y
R
F
G
I
T
K
I
F
F
R
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
14
PsiBlast_PDB
77.14
35%
-95
- C2 -
2JHR
2
MYS2_DICDI
A:
[100-758]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
D
M
S
E
L
S
Y
L
N
E
P
A
V
F
H
N
L
R
V
R
Y
N
Q
-
D
L
I
Y
T
Y
S
G
L
F
L
V
A
V
N
P
F
K
R
I
-
P
I
Y
T
Q
E
M
V
D
I
F
K
G
R
R
R
N
E
V
A
P
H
I
F
A
I
S
D
V
A
Y
R
S
M
L
D
D
R
Q
N
Q
S
L
L
I
T
G
E
S
G
A
G
K
T
E
N
T
K
K
V
I
Q
Y
L
-
A
S
V
A
G
R
---
N
Q
A
NG
S
G
V
L
E
Q
Q
I
L
Q
A
N
P
I
L
E
A
F
G
N
A
K
T
T
R
N
N
N
S
S
R
F
G
K
F
I
E
I
Q
F
N
S
A
G
F
I
S
G
A
S
I
Q
S
Y
L
L
E
K
S
R
V
V
F
Q
S
E
T
E
R
N
Y
H
I
F
Y
Q
L
L
A
G
A
T
-------
A
E
E
K
K
A
-
L
H
L
A
G
P
E
S
F
N
Y
L
-
N
-
Q
S
G
C
-
V
--
D
--
I
K
G
V
-
S
D
S
E
----------
E
F
K
I
T
R
Q
A
--
M
D
I
V
G
F
S
Q
E
E
Q
M
S
I
F
K
I
I
A
G
I
L
H
L
G
N
I
K
F
E
K
G
A
G
E
G
A
V
L
K
D
K
T
-----
A
L
N
A
A
S
T
V
F
G
-
V
N
P
S
V
L
E
K
A
L
M
E
P
R
I
L
A
-----
G
R
D
L
V
A
Q
H
L
N
V
E
K
S
S
S
S
R
D
A
L
V
K
A
L
Y
G
R
L
F
L
W
L
V
K
K
I
N
N
V
L
------
C
Q
E
R
K
A
Y
F
I
G
V
L
D
I
S
G
F
E
I
F
K
V
N
S
F
E
Q
L
C
I
N
Y
T
N
E
K
L
Q
Q
F
F
N
H
H
M
F
K
L
E
Q
E
E
Y
L
K
E
K
I
N
W
T
F
I
D
F
G
L
D
S
Q
A
T
I
D
L
I
D
G
R
Q
P
P
G
I
L
A
L
L
D
E
Q
S
V
F
P
N
A
T
D
N
T
L
I
T
----
K
L
H
S
H
F
--
S
K
K
NA
K
Y
E
--------
E
P
R
-----
F
S
K
T
E
----------
F
G
V
T
H
Y
A
G
Q
V
M
Y
E
I
Q
D
W
L
E
K
N
K
D
P
L
Q
Q
D
L
E
L
C
F
K
D
S
S
D
-
N
V
V
T
K
L
F
N
D
P
-----
N
I
A
-----------------
S
R
A
K
K
G
A
N
F
I
---------------
T
V
A
A
Q
Y
K
E
Q
L
A
S
L
M
A
T
L
E
T
T
N
P
H
F
V
R
C
I
I
P
N
N
K
Q
L
P
A
K
L
E
D
K
V
V
L
D
Q
L
R
C
N
G
V
L
E
G
I
R
I
T
R
K
G
F
P
N
R
I
I
Y
A
D
F
V
K
R
Y
--
Y
L
L
A
P
N
V
-
P
R
D
A
E
D
S
--
Q
K
A
T
D
-
A
V
L
K
H
L
N
I
--
D
PE
Q
Y
R
F
G
I
T
K
I
F
F
R
A
G
Q
L
A
R
I
E
E
A
R
E
Q
R
L
-
E
S
N
E
-
P
P
M
D
F
D
D
D
I
P
F
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
15
PsiBlast_PDB
76.17
35%
-93
- C2 -
2JJ9
1
MYS2_DICDI
A:
[100-704]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
D
M
S
E
L
S
Y
L
N
E
P
A
V
F
H
N
L
R
V
R
Y
N
Q
-
D
L
I
Y
T
Y
S
G
L
F
L
V
A
V
N
P
F
K
R
I
-
P
I
Y
T
Q
E
M
V
D
I
F
K
G
R
R
R
N
E
V
A
P
H
I
F
A
I
S
D
V
A
Y
R
S
M
L
D
D
R
Q
N
Q
S
L
L
I
T
G
E
S
G
A
G
K
T
E
N
T
K
K
V
I
Q
Y
L
-
A
S
V
A
G
R
---
N
Q
A
NGSG
V
L
E
Q
Q
I
L
Q
A
N
P
I
L
E
A
F
G
N
A
K
T
T
R
N
N
N
S
S
R
F
G
K
F
I
E
I
Q
F
N
S
A
G
F
I
S
G
A
S
I
Q
S
Y
L
L
E
K
S
R
V
V
F
Q
S
E
T
E
R
N
Y
H
I
F
Y
Q
L
L
A
G
A
T
-------
A
E
E
K
K
A
-
L
H
L
A
G
P
E
S
F
N
Y
L
-
N
-
Q
S
G
C
-
V
--
D
--
I
K
G
V
-
S
D
S
E
----------
E
F
K
I
T
R
Q
A
--
M
D
I
V
G
F
S
Q
E
E
Q
M
S
I
F
K
I
I
A
G
I
L
H
L
G
N
I
K
F
E
K
G
A
G
E
G
A
V
L
K
D
K
T
-----
A
L
N
A
A
S
T
V
F
G
-
V
N
P
S
V
L
E
K
A
L
M
E
P
R
I
L
A
-----
G
R
D
L
V
A
Q
H
L
N
V
E
K
S
S
S
S
R
D
A
L
V
K
A
L
Y
G
R
L
F
L
W
L
V
K
K
I
N
N
V
L
------
C
Q
E
R
K
A
Y
F
I
G
V
L
D
I
S
G
F
E
I
F
K
V
N
S
F
E
Q
L
C
I
N
Y
T
N
E
K
L
Q
Q
F
F
N
H
H
M
F
K
L
E
Q
E
E
Y
L
K
E
K
I
N
W
T
F
I
D
F
G
L
D
S
Q
A
T
I
D
L
I
D
G
R
Q
P
P
G
I
L
A
L
L
D
E
Q
S
V
F
P
N
A
T
D
N
T
L
I
T
----
K
L
H
S
H
F
--
S
K
K
NA
K
Y
E
--------
E
P
R
-----
F
S
K
T
E
----------
F
G
V
T
H
Y
A
G
Q
V
M
Y
E
I
Q
D
W
L
E
K
N
K
D
P
L
Q
Q
D
L
E
L
C
F
K
D
S
S
D
-
N
V
V
T
K
L
F
N
D
P
-----
N
I
A
-----------------
S
R
A
K
K
G
A
N
F
I
---------------
T
V
A
A
Q
Y
K
E
Q
L
A
S
L
M
A
T
L
E
T
T
N
P
H
F
V
R
C
I
I
P
N
N
K
Q
L
P
A
K
L
E
D
K
V
V
L
D
Q
L
R
C
N
G
V
L
E
G
I
R
I
T
R
K
G
F
P
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
69
PsiBlast_CBE
76.02
32%
-83
- C2 -
3I5F
1
?
A:
[62-835]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
T
Q
E
T
R
V
V
K
K
D
D
I
G
Q
R
N
P
P
K
F
E
M
N
M
D
M
A
N
L
T
F
L
N
E
A
S
I
L
H
N
L
R
S
R
Y
E
S
-
G
F
I
Y
T
Y
S
G
L
F
C
I
A
I
N
P
Y
R
R
L
-
P
I
Y
T
Q
G
L
V
D
K
Y
R
G
K
R
R
A
E
M
P
P
H
L
F
S
I
A
D
N
A
Y
Q
Y
M
L
Q
D
R
E
N
Q
S
M
L
I
T
G
E
S
G
A
G
K
T
E
N
T
K
K
V
I
Q
Y
F
-
A
L
V
A
A
S
LAE
K
K
G
----
T
L
E
D
Q
I
V
Q
C
N
P
V
L
E
A
Y
G
N
A
K
T
T
R
N
N
N
S
S
R
F
G
K
F
I
R
I
H
F
G
T
Q
G
K
I
A
G
A
D
I
E
T
Y
L
L
E
K
S
R
V
T
Y
Q
Q
S
A
E
R
N
Y
H
I
F
Y
Q
L
L
S
P
A
F
-------
P
E
N
I
E
K
I
L
A
V
P
D
--
P
G
L
Y
G
F
I
-
N
Q
G
T
-
L
T
V
D
--
G
I
D
D
E
E
-------------
E
M
G
L
T
D
T
A
--
F
D
V
L
G
F
T
D
E
E
K
L
S
M
Y
K
C
T
G
C
I
L
H
L
G
E
M
K
W
K
Q
R
G
E
Q
A
E
A
D
G
T
-----
A
E
A
-
E
K
V
A
F
L
L
G
-
V
N
A
G
D
L
L
K
C
L
L
K
P
K
I
K
V
-----
G
T
E
Y
V
T
Q
G
R
N
K
D
Q
V
T
N
S
I
A
A
L
A
K
S
L
Y
D
R
M
F
N
W
L
V
R
R
V
N
Q
T
L
D
-----
T
K
A
K
R
Q
F
F
I
G
V
L
D
I
A
G
F
E
I
F
D
F
N
S
F
E
Q
L
C
I
N
Y
T
N
E
R
L
Q
Q
F
F
N
H
H
M
F
V
L
E
Q
E
E
Y
K
K
E
G
I
V
W
E
F
I
D
F
G
-
L
D
L
Q
A
C
I
E
L
I
-
E
K
P
M
G
I
L
S
I
L
E
E
E
C
M
F
P
K
A
S
D
T
S
F
K
N
----
K
L
Y
D
N
H
--
L
G
K
NP
M
F
G
--------
K
P
K
P
P
KAG
C
A
E
A
H
----------
F
C
L
H
H
Y
A
G
S
V
S
Y
S
I
A
G
W
L
D
K
N
K
D
P
I
N
E
N
V
V
E
L
L
Q
N
S
K
E
-
P
I
V
K
M
L
F
T
P
----------------------------
A
--------------------
F
Q
T
I
S
S
V
H
K
E
S
L
N
K
L
M
K
N
L
Y
S
T
H
P
H
F
V
R
C
I
I
P
N
E
L
K
T
P
G
L
I
D
A
A
L
V
L
H
Q
L
R
C
N
G
V
L
E
G
I
R
I
C
R
K
G
F
P
N
R
I
I
Y
S
E
F
K
Q
R
Y
--
S
I
L
A
P
N
A
-
V
P
S
G
F
A
D
--
G
K
V
V
T
D
K
A
L
S
A
L
Q
L
--
D
PN
E
Y
R
L
G
N
T
K
V
F
F
K
A
G
V
L
G
M
L
E
D
M
R
D
E
R
L
-
S
K
I
I
S
M
F
Q
A
H
I
R
G
Y
L
M
R
K
A
Y
K
K
L
Q
D
Q
R
-
I
G
L
T
L
I
Q
R
N
V
R
K
W
L
V
L
R
N
W
E
W
W
R
L
F
N
K
V
K
P
L
L
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
41
PsiBlast_CBE
75.91
35%
-91
- C2 -
2Y8I
1
MYS2_DICDI
X:
[88-746]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
D
M
S
E
L
S
Y
L
N
E
P
A
V
F
H
N
L
R
V
R
Y
N
Q
-
D
L
I
Y
T
Y
S
G
L
F
L
V
A
V
N
P
F
K
R
I
-
P
I
Y
T
Q
E
M
V
D
I
F
K
G
R
R
R
N
E
V
A
P
H
I
F
A
I
S
D
V
A
Y
R
S
M
L
D
D
R
Q
N
Q
S
L
L
I
T
G
E
S
G
A
G
K
T
E
N
T
K
K
V
I
Q
Y
L
-
A
S
V
A
G
R
---
N
Q
A
NGSG
V
L
E
Q
Q
I
L
Q
A
N
P
I
L
E
A
F
G
N
A
K
T
T
R
N
N
N
S
S
R
F
G
K
F
I
E
I
Q
F
N
S
A
G
F
I
S
G
A
S
I
Q
S
Y
L
L
E
K
S
R
V
V
F
Q
S
E
T
E
R
N
Y
H
I
F
Y
Q
L
L
A
G
A
T
-------
A
E
E
K
K
A
-
L
H
L
A
G
P
E
S
F
N
Y
L
-
N
-
Q
S
G
C
-
V
--
D
--
I
K
G
V
-
S
D
S
E
----------
E
F
K
I
T
R
Q
A
--
M
D
I
V
G
F
S
Q
E
E
Q
M
S
I
F
K
I
I
A
G
I
L
H
L
G
N
I
K
F
E
K
G
A
G
E
G
A
V
L
K
D
K
T
-----
A
L
N
A
A
S
T
V
F
G
-
V
N
P
S
V
L
E
K
A
L
M
E
P
R
I
L
A
-----
G
R
D
L
V
A
Q
H
L
N
V
E
K
S
S
S
S
R
D
A
L
V
K
A
L
Y
G
R
L
F
L
W
L
V
K
K
I
N
N
V
L
------
C
Q
E
R
K
A
Y
F
I
G
V
L
D
I
S
G
F
E
I
F
K
V
N
S
F
E
Q
L
C
I
N
Y
T
N
E
K
L
Q
Q
F
F
N
H
H
M
F
K
L
E
Q
E
E
Y
L
K
E
K
I
N
W
T
F
I
D
F
G
L
D
S
Q
A
T
I
D
L
I
D
G
R
Q
P
P
G
I
L
A
L
L
D
E
Q
S
V
F
P
N
A
T
D
N
T
L
I
T
----
K
L
H
S
H
F
--
S
K
K
NA
K
Y
E
--------
E
P
R
-----
F
S
K
T
E
----------
F
G
V
T
H
Y
A
G
Q
V
M
Y
E
I
Q
D
W
L
E
K
N
K
D
P
L
Q
Q
D
L
E
L
C
F
K
D
S
S
D
-
N
V
V
T
K
L
F
N
D
P
-----
N
I
A
-----------------
S
R
A
K
K
G
A
N
F
I
---------------
T
V
A
A
Q
Y
K
E
Q
L
A
S
L
M
A
T
L
E
T
T
N
P
H
F
V
R
C
I
I
P
N
N
K
Q
L
P
A
K
L
E
D
K
V
V
L
D
Q
L
R
C
N
A
V
L
E
G
I
R
I
T
R
K
G
F
P
N
R
I
I
Y
A
D
F
V
K
R
Y
--
Y
L
L
A
P
N
V
-
P
R
D
A
E
D
S
--
Q
K
A
T
D
-
A
V
L
K
H
L
N
I
--
D
PE
Q
Y
R
F
G
I
T
K
I
F
F
R
A
G
Q
L
A
R
I
E
E
A
R
E
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
57
PsiBlast_CBE
75.71
36%
-93
- C2 -
2X9H
2
MYS2_DICDI
A:
[88-695]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
D
M
S
E
L
S
Y
L
N
E
P
A
V
F
H
N
L
R
V
R
Y
N
Q
-
D
L
I
Y
T
Y
S
G
L
F
L
V
A
V
N
P
F
K
I
I
-
P
I
Y
T
Q
E
M
V
D
I
F
K
G
R
R
R
N
E
V
A
P
H
I
F
A
I
S
D
V
A
Y
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M
L
D
D
R
Q
N
Q
S
L
L
I
T
G
E
S
G
A
G
K
T
E
N
T
K
K
V
I
Q
Y
L
-
A
S
V
A
G
R
------GSG-
V
L
E
Q
Q
I
L
Q
A
N
P
I
L
E
A
F
G
N
A
K
T
T
R
N
N
N
S
S
R
F
G
K
F
I
E
I
Q
F
N
S
A
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I
S
G
A
S
I
Q
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L
L
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S
R
V
V
F
Q
S
E
T
E
R
N
Y
H
I
F
Y
Q
L
L
A
G
A
T
-------
A
E
E
K
K
A
-
L
H
L
A
G
P
E
S
F
N
Y
L
-
N
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S
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V
--
D
--
I
K
G
V
-
S
D
S
E
----------
E
F
K
I
T
R
Q
A
--
M
D
I
V
G
F
S
Q
E
E
Q
M
S
I
F
K
I
I
A
G
I
L
H
L
G
N
I
K
F
E
K
G
A
G
E
G
A
V
L
K
D
K
T
-----
A
L
N
A
A
S
T
V
F
G
-
V
N
P
S
V
L
E
K
A
L
M
E
P
R
I
L
A
-----
G
R
D
L
V
A
Q
H
L
N
V
E
K
S
S
S
S
R
D
A
L
V
K
A
L
Y
G
R
L
F
L
W
L
V
I
K
I
N
N
V
L
------
C
Q
E
R
K
A
Y
F
I
G
V
L
D
I
S
G
F
E
I
F
K
V
N
S
F
E
Q
L
C
I
N
Y
T
N
E
K
L
Q
Q
F
F
N
H
H
M
F
K
L
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Q
E
E
Y
L
K
E
K
I
N
W
T
F
I
D
F
G
L
D
S
Q
A
T
I
D
L
I
D
G
R
Q
P
P
G
I
L
A
L
L
D
E
Q
S
V
F
P
N
A
T
D
N
T
L
I
T
----
K
L
H
S
H
F
--
S
K
K
NA
K
Y
E
--------
E
P
R
-----
F
S
K
T
E
----------
F
G
V
T
H
Y
A
G
Q
V
M
Y
E
I
Q
D
W
L
E
K
N
K
D
P
L
Q
Q
D
L
E
L
C
F
K
D
S
S
D
-
N
V
V
T
K
L
F
N
D
P
-----
N
I
A
-----------------
S
R
A
K
K
G
A
N
F
I
---------------
T
V
A
A
Q
Y
K
E
Q
L
A
S
L
M
A
T
L
E
T
T
N
P
H
F
V
R
C
I
I
P
N
N
K
Q
L
P
A
K
L
E
D
K
V
V
L
D
Q
L
R
C
N
G
V
L
E
G
I
R
I
T
R
K
G
F
P
N
R
I
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
56
PsiBlast_CBE
75.02
36%
-92
- C2 -
3MKD
1
MYS2_DICDI
A:
[88-691]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
D
M
S
E
L
S
Y
L
N
E
P
A
V
F
H
N
L
R
V
R
Y
N
Q
-
D
L
I
Y
T
Y
S
G
L
F
L
V
A
V
N
P
F
K
R
I
-
P
I
Y
T
Q
E
M
V
D
I
F
K
G
R
R
R
N
E
V
A
P
H
I
F
A
I
S
D
V
A
Y
R
S
M
L
D
D
R
Q
N
Q
S
L
L
I
T
G
E
S
G
A
G
K
T
E
N
T
K
K
V
I
Q
Y
L
-
A
S
V
A
G
R
---
N
Q
A
NGSG
V
L
E
Q
Q
I
L
Q
A
N
P
I
L
E
A
F
G
N
A
K
T
T
R
N
N
N
S
S
R
F
G
K
F
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E
I
Q
F
N
S
A
G
F
I
S
G
A
S
I
Q
S
Y
L
L
E
K
S
R
V
V
F
Q
S
E
T
E
R
N
Y
H
I
F
Y
Q
L
L
A
G
A
T
-------
A
E
E
K
K
A
-
L
H
L
A
G
P
E
S
F
N
Y
L
-
N
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Q
S
G
C
-
V
--
D
--
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K
G
V
-
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D
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E
----------
E
F
K
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T
R
Q
A
--
M
D
I
V
G
F
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Q
E
E
Q
M
S
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F
K
I
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A
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L
H
L
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K
F
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K
G
A
G
E
G
A
V
L
K
D
K
T
-----
A
L
N
A
A
S
T
V
F
G
-
V
N
P
S
V
L
E
K
A
L
M
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P
R
I
L
A
-----
G
R
D
L
V
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Q
H
L
N
V
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K
S
S
S
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D
A
L
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A
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L
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W
L
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K
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N
N
V
L
------
C
Q
E
R
K
A
Y
F
I
G
V
L
D
I
Y
G
F
E
I
F
K
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N
S
F
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Q
L
C
I
N
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T
N
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K
L
Q
Q
F
F
N
H
H
M
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K
L
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E
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Y
L
K
E
K
I
N
W
T
F
I
D
F
G
L
D
S
Q
A
T
I
D
L
I
D
G
R
Q
P
P
G
I
L
A
L
L
D
E
Q
S
V
F
P
N
A
T
D
N
T
L
I
T
----
K
L
H
S
H
F
--
S
K
K
NA
K
Y
E
--------
E
P
R
-----
F
S
K
T
E
----------
F
G
V
T
H
Y
A
G
Q
V
M
Y
E
I
Q
D
W
L
E
K
N
K
D
P
L
Q
Q
D
L
E
L
C
F
K
D
S
S
D
-
N
V
V
T
K
L
F
N
D
P
-----
N
I
A
-----------------
S
R
A
K
K
G
A
N
F
I
---------------
T
V
A
A
Q
Y
K
E
Q
L
A
S
L
M
A
T
L
E
T
T
N
P
H
F
V
R
C
I
I
P
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N
K
Q
L
P
A
K
L
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D
K
V
V
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L
R
C
N
G
V
L
E
G
I
R
I
T
R
K
G
F
P
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
72
PsiBlast_CBE
74.68
31%
-83
- C2 -
3L9I
1
MYO6_PIG
A:
[48-796]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
P
A
E
E
D
S
K
K
D
V
E
D
N
-
C
S
L
M
Y
L
N
E
A
T
L
L
H
N
I
K
V
R
Y
S
K
-
D
R
I
Y
T
Y
V
A
N
I
L
I
A
V
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P
Y
F
D
I
P
K
I
Y
S
S
E
T
I
K
S
Y
Q
G
K
S
L
G
T
M
P
P
H
V
F
A
I
A
D
K
A
F
R
D
M
K
V
L
K
L
S
Q
S
I
I
V
S
G
E
S
G
A
G
K
T
E
N
T
K
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Y
L
-
T
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Y
G
---
T
G
Q
----
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D
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V
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A
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P
L
L
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A
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G
N
A
K
T
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R
N
N
N
S
S
R
F
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K
F
V
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I
H
F
N
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S
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V
V
G
G
F
V
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H
Y
L
L
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C
V
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G
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F
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C
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S
L
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D
PGLD
D
H
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D
F
I
R
M
C
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M
K
K
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L
D
D
E
E
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L
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--
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-
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-----
S
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V
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D
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N
S
F
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F
C
I
N
Y
C
N
E
K
L
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F
F
N
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R
I
L
K
E
E
Q
E
L
Y
Q
K
E
G
L
G
V
N
E
V
H
Y
V
-
D
N
Q
D
C
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D
L
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R
L
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I
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A
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H
Q
K
H
K
D
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F
--
R
L
S
--
I
-----------
P
R
-----
K
S
K
L
A
IHRNIRDDE
G
F
I
I
R
H
F
A
G
A
V
C
Y
E
T
T
Q
F
V
E
K
N
N
D
A
L
H
M
S
L
E
S
L
I
C
E
S
R
D
-
K
F
I
R
E
L
F
E
--------------------------------------
F
I
------------
S
V
G
N
K
F
K
T
Q
L
N
L
L
L
D
K
L
R
S
T
G
A
S
F
I
R
C
I
K
P
N
L
K
M
T
S
H
H
F
E
G
A
Q
I
L
S
Q
L
Q
C
S
G
M
V
S
V
L
D
L
M
Q
G
G
F
P
S
R
A
S
F
H
E
L
Y
N
M
Y
KK
Y
M
P
D
K
L
A
-
R
L
D
P
R
L
F
--
C
K
A
L
F
-
K
A
L
G
L
N
E
I
--
D
---
Y
K
F
G
L
T
K
V
F
F
R
P
G
K
F
A
E
F
D
Q
I
M
K
S
D
P
-
D
H
L
A
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E
L
V
K
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V
N
H
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S
R
W
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K
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C
S
L
S
V
I
K
L
K
N
---
K
I
K
---
Y
R
A
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
74
PsiBlast_CBE
74.35
31%
-83
- C2 -
4DBP
21
MYO6_PIG
A:
[48-796]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
P
A
E
E
D
S
K
K
D
V
E
D
N
-
C
S
L
M
Y
L
N
E
A
T
L
L
H
N
I
K
V
R
Y
S
K
-
D
R
I
Y
T
Y
V
A
N
I
L
I
A
V
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P
Y
F
D
I
P
K
I
Y
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S
E
T
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K
S
Y
Q
G
K
S
L
G
T
M
P
P
H
V
F
A
I
A
D
K
A
F
R
D
M
K
V
L
K
L
S
Q
S
I
I
V
S
G
E
S
G
A
G
K
T
E
N
T
K
F
V
L
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Y
L
-
T
-
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S
Y
G
---
T
G
Q
----
D
I
Y
D
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V
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A
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P
L
L
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A
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N
A
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T
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N
N
N
S
S
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F
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I
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F
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--
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K
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D
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-----
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--
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-----
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A
IHRNIRDDE
G
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D
-
K
F
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R
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L
F
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--------------------------------------
F
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------------
S
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L
L
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N
E
I
--
D
---
Y
K
F
G
L
T
K
V
F
F
R
P
G
K
F
A
E
F
D
Q
I
M
K
S
D
P
-
D
H
L
A
-
E
L
V
K
R
V
N
H
W
L
I
C
S
R
W
K
K
V
Q
W
C
S
L
S
V
I
K
L
K
N
---
K
I
K
---
Y
R
A
E
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
16
PsiBlast_PDB
74.33
35%
-94
- C2 -
3MJX
2
MYS2_DICDI
A:
[100-709]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
D
M
S
E
L
S
Y
L
N
E
P
A
V
F
H
N
L
R
V
R
Y
N
Q
-
D
L
I
Y
T
Y
S
G
L
F
L
V
A
V
N
P
F
K
R
I
-
P
I
Y
T
Q
E
M
V
D
I
F
K
G
R
R
R
N
E
V
A
P
H
I
F
A
I
S
D
V
A
Y
R
S
M
L
D
D
R
Q
N
Q
S
L
L
I
T
G
E
S
G
A
G
K
T
E
N
T
K
K
V
I
Q
Y
L
-
A
S
V
A
G
-------G---
V
L
E
Q
Q
I
L
Q
A
N
P
I
L
E
A
F
G
N
A
K
T
T
R
N
N
N
S
S
R
F
G
K
F
I
E
I
Q
F
N
S
A
G
F
I
S
G
A
S
I
Q
S
Y
L
L
E
K
S
R
V
V
F
Q
S
E
T
E
R
N
Y
H
I
F
Y
Q
L
L
A
G
A
T
-------
A
E
E
K
K
A
-
L
H
L
A
G
P
E
S
F
N
Y
L
-
N
-
Q
S
G
C
-
V
--
D
--
I
K
G
V
-
S
D
S
E
----------
E
F
K
I
T
R
Q
A
--
M
D
I
V
G
F
S
Q
E
E
Q
M
S
I
F
K
I
I
A
G
I
L
H
L
G
N
I
K
F
E
K
G
A
G
E
G
A
V
L
K
D
K
T
-----
A
L
N
A
A
S
T
V
F
G
-
V
N
P
S
V
L
E
K
A
L
M
E
P
R
I
L
A
-----
G
R
D
L
V
A
Q
H
L
N
V
E
K
S
S
S
S
R
D
A
L
V
K
A
L
Y
G
R
L
F
L
W
L
V
K
K
I
N
N
V
L
------
C
Q
E
R
K
A
Y
F
I
G
V
L
D
I
S
G
F
E
I
F
K
V
N
S
F
E
Q
L
C
I
N
Y
T
N
E
K
L
Q
Q
F
F
N
H
H
M
F
K
L
E
Q
E
E
Y
L
K
E
K
I
N
W
T
F
I
D
F
G
L
D
S
Q
A
T
I
D
L
I
D
G
R
Q
P
P
G
I
L
A
L
L
D
E
Q
S
V
F
P
N
A
T
D
N
T
L
I
T
----
K
L
H
S
H
F
--
S
K
K
NA
K
Y
E
--------
E
P
R
-----
F
S
K
T
E
----------
F
G
V
T
H
Y
A
G
Q
V
M
Y
E
I
Q
D
W
L
E
K
N
K
D
P
L
Q
Q
D
L
E
L
C
F
K
D
S
S
D
-
N
V
V
T
K
L
F
N
D
P
-----
N
I
A
-----------------
S
R
A
K
K
G
A
N
F
I
---------------
T
V
A
A
Q
Y
K
E
Q
L
A
S
L
M
A
T
L
E
T
T
N
P
H
F
V
R
C
I
I
P
N
N
K
Q
L
P
A
K
L
E
D
K
V
V
L
D
Q
L
R
C
N
G
V
L
E
G
I
R
I
T
R
K
G
F
P
N
R
I
I
Y
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
73
PsiBlast_CBE
73.60
31%
-83
- C2 -
2BKH
6
MYO6_PIG
A:
[48-796]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
P
A
E
E
D
S
K
K
D
V
E
D
N
-
C
S
L
M
Y
L
N
E
A
T
L
L
H
N
I
K
V
R
Y
S
K
-
D
R
I
Y
T
Y
V
A
N
I
L
I
A
V
N
P
Y
F
D
I
P
K
I
Y
S
S
E
T
I
K
S
Y
Q
G
K
S
L
G
T
M
P
P
H
V
F
A
I
A
D
K
A
F
R
D
M
K
V
L
K
L
S
Q
S
I
I
V
S
G
E
S
G
A
G
K
T
E
N
T
K
F
V
L
R
Y
L
-
T
-
E
S
Y
G
---
T
G
Q
----
D
I
D
D
R
I
V
E
A
N
P
L
L
E
A
F
G
N
A
K
T
V
R
N
N
N
S
S
R
F
G
K
F
V
E
I
H
F
N
E
K
S
S
V
V
G
G
F
V
S
H
Y
L
L
E
K
S
R
I
C
V
Q
G
K
E
E
R
N
Y
H
I
F
Y
R
L
C
A
G
A
S
E
D
I
R
E
R
L
H
L
S
S
P
D
N
F
R
Y
L
N
R
G
C
T
R
Y
F
A
N
K
E
T
D
K
Q
I
L
Q
N
--
R
K
S
P
E
Y
L
K
A
G
S
L
K
D
PLLD
D
H
G
D
F
I
R
M
C
T
A
M
K
K
I
G
L
D
D
E
E
K
L
D
L
F
R
V
V
A
G
V
L
H
L
G
N
I
D
F
E
E
A
G
-----
C
N
L
K
N
-
K
S
T
Q
A
L
E
Y
C
A
E
L
L
G
-
L
D
Q
D
D
L
R
V
S
L
T
T
R
V
M
L
T
TAGG
A
K
G
T
V
I
K
V
P
L
K
V
E
Q
A
N
N
A
R
D
A
L
A
K
T
V
Y
S
H
L
F
D
H
V
V
N
R
V
N
Q
C
F
-
P
F
E
T
-----
S
S
Y
F
I
G
V
L
D
I
A
G
F
E
Y
F
E
H
N
S
F
E
Q
F
C
I
N
Y
C
N
E
K
L
Q
Q
F
F
N
E
R
I
L
K
E
E
Q
E
L
Y
Q
K
E
G
L
G
V
N
E
V
H
Y
V
-
D
N
Q
D
C
I
D
L
I
E
-
A
R
L
V
G
I
L
D
I
L
D
E
E
N
R
L
P
Q
P
S
D
Q
H
F
T
S
A
V
H
Q
K
H
K
D
H
F
--
R
L
S
--
I
-----------
P
R
-----
K
S
K
L
A
IHRNIRDDE
G
F
I
I
R
H
F
A
G
A
V
C
Y
E
T
T
Q
F
V
E
K
N
N
D
A
L
H
M
S
L
E
S
L
I
C
E
S
R
D
-
K
F
I
R
E
L
F
E
--------------------------------------
F
I
------------
S
V
G
N
K
F
K
T
Q
L
N
L
L
L
D
K
L
R
S
T
G
A
S
F
I
R
C
I
K
P
N
L
K
M
T
S
H
H
F
E
G
A
Q
I
L
S
Q
L
Q
C
S
G
M
V
S
V
L
D
L
M
Q
G
G
F
P
S
R
A
S
F
H
E
L
Y
N
M
Y
KK
Y
M
P
D
K
L
A
-
R
L
D
P
R
L
F
--
C
K
A
L
F
-
K
A
L
G
L
N
E
I
--
D
---
Y
K
F
G
L
T
K
V
F
F
R
P
G
K
F
A
E
F
D
Q
I
M
K
S
D
P
-
D
H
L
A
-
E
L
V
K
R
V
N
H
W
L
I
C
S
R
W
K
K
V
Q
W
C
S
L
S
V
I
K
L
K
N
---
K
I
K
---
Y
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
62
PsiBlast_CBE
73.56
33%
-92
- C2 -
1KQM
1
MYS_ARGIR
A:
[86-825]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
D
M
A
N
M
T
Y
L
N
E
A
S
V
L
Y
N
L
R
S
R
Y
T
S
-
G
L
I
Y
T
Y
S
G
L
F
C
I
A
V
N
P
Y
R
R
L
-
P
I
Y
T
D
S
V
I
A
K
Y
R
G
K
R
K
T
E
I
P
P
H
L
F
S
V
A
D
N
A
Y
Q
N
M
V
T
D
R
E
N
Q
S
C
L
I
T
G
E
S
G
A
G
K
T
E
N
T
K
K
V
I
M
Y
L
-
A
K
V
A
C
A
---
V
--G---
S
L
E
D
Q
I
I
Q
A
N
P
V
L
E
A
Y
G
N
A
K
T
T
R
N
N
N
S
S
R
F
G
K
F
I
R
I
H
F
G
P
T
G
K
I
A
G
A
D
I
E
T
Y
L
L
E
K
S
R
V
T
Y
Q
Q
S
A
E
R
N
Y
H
I
F
Y
Q
I
C
S
--
N
-------
A
I
P
E
L
N
D
V
M
L
V
T
P
D
S
G
L
Y
S
F
I
-
N
Q
G
C
-
L
T
V
D
N-
I
D
D
V
E
--------------
E
F
K
L
C
D
E
A
--
F
D
I
L
G
F
T
K
E
E
K
Q
S
M
F
K
C
T
A
S
I
L
H
M
G
E
M
K
F
K
-----
E
Q
A
E
S
D
G
T
-
A
E
A
E
K
V
----
A
F
L
C
G
I
N
A
G
D
L
L
K
A
L
L
K
P
K
V
K
V
--------
M
V
T
K
G
Q
N
M
N
Q
V
V
N
S
V
G
A
L
A
K
S
L
Y
D
R
M
F
N
W
L
V
R
R
V
N
K
T
L
D
-----
T
K
A
K
R
N
Y
Y
I
G
V
L
D
I
A
G
F
E
I
F
D
F
N
S
F
E
Q
L
C
I
N
Y
T
N
E
R
L
Q
Q
F
F
N
H
H
M
F
I
L
E
Q
E
E
Y
K
K
E
G
I
A
W
E
--
D
F
G
-
M
D
L
Q
M
C
I
D
L
I
-
E
K
P
M
G
I
L
S
I
L
E
E
E
C
---
K
A
D
D
K
S
F
Q
D
----
K
L
Y
Q
N
H
--
M
G
K
--
N
R
M
F
T
K
P
G
K
PT
R
P
N
-----
Q
G
P
A
H
----------
F
E
L
H
H
Y
A
G
N
V
P
Y
S
I
T
G
W
L
E
K
N
K
D
P
I
N
E
N
V
V
A
L
L
G
A
S
K
E
-
P
L
V
A
E
L
F
K
A
P
E
E
P
----------------
A
F
----------------------------
Q
T
I
S
A
V
H
R
E
S
L
N
K
L
M
K
N
L
Y
S
T
H
P
H
F
V
R
C
I
I
P
N
E
L
K
Q
P
G
L
V
D
A
E
L
V
L
H
Q
L
Q
C
N
G
V
L
E
------
K
G
F
P
S
R
L
I
Y
S
E
F
K
Q
R
Y
--
S
I
L
A
P
N
A
I-----
D
G
--
K
T
V
S
E
-
K
I
L
A
G
L
Q
M
--
D
PA
E
Y
R
L
G
T
T
K
V
F
F
K
A
G
V
L
G
N
L
E
E
M
R
D
E
R
L
-
S
K
I
I
S
M
F
Q
A
H
I
R
G
Y
L
I
R
K
A
Y
K
K
L
Q
D
Q
R
-
I
G
L
S
V
I
Q
---
R
N
I
---
R
K
W
L
V
L
R
N
W
Q
W
W
K
L
Y
S
K
V
K
P
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
86
PsiBlast_CBE
73.42
31%
-84
- C2 -
4PFO
15
?
A:
[48-787]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
P
A
E
E
D
S
K
K
D
V
E
D
N
-
C
S
L
M
Y
L
N
E
A
T
L
L
H
N
I
K
V
R
Y
S
K
-
D
R
I
Y
T
Y
V
A
N
I
L
I
A
V
N
P
Y
F
D
I
P
K
I
Y
S
S
E
T
I
K
S
Y
Q
G
K
S
L
G
T
M
P
P
H
V
F
A
I
A
D
K
A
F
R
D
M
K
V
L
K
L
S
Q
S
I
I
V
S
G
E
S
G
A
G
K
T
E
N
T
K
F
V
L
R
Y
L
-
T
-
E
S
Y
G
---
T
---------
D
R
I
V
E
A
N
P
L
L
E
A
F
G
N
A
K
T
V
R
N
N
N
S
S
R
F
G
K
F
V
E
I
H
F
N
E
K
S
S
V
V
G
G
F
V
S
H
Y
L
L
E
K
S
R
I
C
V
Q
G
K
E
E
R
N
Y
H
I
F
Y
R
L
C
A
G
A
S
E
D
I
R
E
R
L
H
L
S
S
P
D
N
F
R
Y
L
N
R
G
C
T
R
Y
F
A
N
K
E
T
D
K
Q
I
L
Q
N
--
R
K
S
P
E
Y
L
K
A
G
S
L
K
D
PLLD
D
H
G
D
F
I
R
M
C
T
A
M
K
K
I
G
L
D
D
E
E
K
L
D
L
F
R
V
V
A
G
V
L
H
L
G
N
I
D
F
E
E
A
G
S
T
S
G
G
C
N
L
K
N
-
K
S
T
Q
A
L
E
Y
C
A
E
L
L
G
-
L
D
Q
D
D
L
R
V
S
L
T
T
R
V
M
----------
V
I
K
V
P
L
K
V
E
Q
A
N
N
A
R
D
A
L
A
K
T
V
Y
S
H
L
F
D
H
V
V
N
R
V
N
Q
C
F
-
P
F
E
T
-----
S
S
Y
F
I
G
V
L
D
I
A
G
F
E
Y
F
E
H
N
S
F
E
Q
F
C
I
N
Y
C
N
E
K
L
Q
Q
F
F
N
E
R
I
L
K
E
E
Q
E
L
Y
Q
K
E
G
L
G
V
N
E
V
H
Y
V
-
D
N
Q
D
C
I
D
L
I
E
-
A
R
L
V
G
I
L
D
I
L
D
E
E
N
R
L
P
Q
P
S
D
Q
H
F
T
S
A
V
H
Q
K
H
K
D
H
F
--
R
L
S
--
I
-----------
P
R
-----
K
S
K
L
A
IHRNIRDDE
G
F
I
I
R
H
F
A
G
A
V
C
Y
E
T
T
Q
F
V
E
K
N
N
D
A
L
H
M
S
L
E
S
L
I
C
E
S
R
D
-
K
F
I
R
E
L
F
E
------------------------------------
L
S
F
I
------------
S
V
G
N
K
F
K
T
Q
L
N
L
L
L
D
K
L
R
S
T
G
A
S
F
I
R
C
I
K
P
N
L
K
M
T
S
H
H
F
E
G
A
Q
I
L
S
Q
L
Q
C
S
G
M
V
S
V
L
D
L
M
Q
G
G
F
P
S
R
A
S
F
H
E
L
Y
N
M
Y
KK
Y
M
P
D
K
L
A
-
R
L
D
P
R
L
F
--
C
K
A
L
F
-
K
A
L
G
L
N
E
I
--
D
---
Y
K
F
G
L
T
K
V
F
F
R
P
G
K
F
A
E
F
D
Q
I
M
K
S
D
P
-
D
H
L
A
-
E
L
V
K
R
V
N
H
W
L
I
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
87
PsiBlast_CBE
73.02
31%
-85
- C2 -
4PJL
13
?
A:
[48-787]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
P
A
E
E
D
S
K
K
D
V
E
D
N
-
C
S
L
M
Y
L
N
E
A
T
L
L
H
N
I
K
V
R
Y
S
K
-
D
R
I
Y
T
Y
V
A
N
I
L
I
A
V
N
P
Y
F
D
I
P
K
I
Y
S
S
E
T
I
K
S
Y
Q
G
K
S
L
G
T
M
P
P
H
V
F
A
I
A
D
K
A
F
R
D
M
K
V
L
K
L
S
Q
S
I
I
V
S
G
E
S
G
A
G
K
T
E
N
T
K
F
V
L
R
Y
L
-
T
-
E
S
Y
G
---
T
G
Q
----
D
I
D
D
R
I
V
E
A
N
P
L
L
E
A
F
G
N
A
K
T
V
R
N
N
N
S
S
R
F
G
K
F
V
E
I
H
F
N
E
K
S
S
V
V
G
G
F
V
S
H
Y
L
L
E
K
S
R
I
C
V
Q
G
K
E
E
R
N
Y
H
I
F
Y
R
L
C
A
G
A
S
E
D
I
R
E
R
L
H
L
S
S
P
D
N
F
R
Y
L
N
R
G
C
T
R
Y
F
A
N
K
E
T
D
K
Q
I
L
Q
N
--
R
K
S
P
E
Y
L
K
A
G
S
L
K
D
PLLD
D
H
G
D
F
I
R
M
C
T
A
M
K
K
I
G
L
D
D
E
E
K
L
D
L
F
R
V
V
A
G
V
L
H
L
G
N
I
D
F
E
E
A
G
S
T
S
G
G
C
N
L
K
N
-
K
S
T
Q
A
L
E
Y
C
A
E
L
L
G
-
L
D
Q
D
D
L
R
V
S
L
T
T
R
V
M
----------
V
I
K
V
P
L
K
V
E
Q
A
N
N
A
R
D
A
L
A
K
T
V
Y
S
H
L
F
D
H
V
V
N
R
V
N
Q
C
F
-
P
F
E
T
-----
S
S
Y
F
I
G
V
L
D
I
E
G
F
E
Y
F
E
H
N
S
F
E
Q
F
C
I
N
Y
C
N
E
K
L
Q
Q
F
F
N
E
R
I
L
K
E
E
Q
E
L
Y
Q
K
E
G
L
G
V
N
E
V
H
Y
V
-
D
N
Q
D
C
I
D
L
I
E
-
A
R
L
V
G
I
L
D
I
L
D
E
E
N
R
L
P
Q
P
S
D
Q
H
F
T
S
A
V
H
Q
K
H
K
D
H
F
--
R
L
S
--
I
-----------
P
R
-----
K
S
K
L
A
IHRNIRDDE
G
F
I
I
R
H
F
A
G
A
V
C
Y
E
T
T
Q
F
V
E
K
N
N
D
A
L
H
M
S
L
E
S
L
I
C
E
S
R
D
-
K
F
I
R
E
L
F
E
------------------------------------
L
S
F
I
------------
S
V
G
N
K
F
K
T
Q
L
N
L
L
L
D
K
L
R
S
T
G
A
S
F
I
R
C
I
K
P
N
L
K
M
T
S
H
H
F
E
G
A
Q
I
L
S
Q
L
Q
C
S
G
M
V
S
V
L
D
L
M
Q
G
G
F
P
S
R
A
S
F
H
E
L
Y
N
M
Y
KK
Y
M
P
D
K
L
A
-
R
L
D
P
R
L
F
--
C
K
A
L
F
-
K
A
L
G
L
N
E
I
--
D
---
Y
K
F
G
L
T
K
V
F
F
R
P
G
K
F
A
E
F
D
Q
I
M
K
S
D
P
-
D
H
L
A
-
E
L
V
K
R
V
N
H
W
L
I
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
84
PsiBlast_CBE
72.86
31%
-85
- C2 -
4PJM
9
?
A:
[48-787]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
P
A
E
E
D
S
K
K
D
V
E
D
N
-
C
S
L
M
Y
L
N
E
A
T
L
L
H
N
I
K
V
R
Y
S
K
-
D
R
I
Y
T
Y
V
A
N
I
L
I
A
V
N
P
Y
F
D
I
P
K
I
Y
S
S
E
T
I
K
S
Y
Q
G
K
S
L
G
T
M
P
P
H
V
F
A
I
A
D
K
A
F
R
D
M
K
V
L
K
L
S
Q
S
I
I
V
S
G
E
S
G
A
G
K
T
E
N
T
K
F
V
L
R
Y
L
-
T
-
E
S
Y
G
---
T
---------
D
R
I
V
E
A
N
P
L
L
E
A
F
G
N
A
K
T
V
R
N
N
N
S
S
R
F
G
K
F
V
E
I
H
F
N
E
K
S
S
V
V
G
G
F
V
S
H
Y
L
L
E
K
S
R
I
C
V
Q
G
K
E
E
R
N
Y
H
I
F
Y
R
L
C
A
G
A
S
E
D
I
R
E
R
L
H
L
S
S
P
D
N
F
R
Y
L
N
R
G
C
T
R
Y
F
A
N
K
E
T
D
K
Q
I
L
Q
N
--
R
K
S
P
E
Y
L
K
A
G
S
L
K
D
PLLD
D
H
G
D
F
I
R
M
C
T
A
M
K
K
I
G
L
D
D
E
E
K
L
D
L
F
R
V
V
A
G
V
L
H
L
G
N
I
D
F
E
E
A
G
S
T
S
G
G
C
N
L
K
N
-
K
S
T
Q
A
L
E
Y
C
A
E
L
L
G
-
L
D
Q
D
D
L
R
V
S
L
T
T
R
V
M
L
----------
I
K
V
P
L
K
V
E
Q
A
N
N
A
R
D
A
L
A
K
T
V
Y
S
H
L
F
D
H
V
V
N
R
V
N
Q
C
F
-
P
F
E
T
-----
S
S
Y
F
I
G
V
L
D
I
A
G
F
E
Y
F
E
H
N
S
F
E
Q
F
C
I
N
Y
C
N
E
K
L
Q
Q
F
F
N
E
R
I
L
K
E
E
Q
E
L
Y
Q
K
E
G
L
G
V
N
E
V
H
Y
V
-
D
N
Q
D
C
I
D
L
I
E
-
A
R
L
V
G
I
L
D
I
L
D
E
E
N
R
L
P
Q
P
S
D
Q
H
F
T
S
A
V
H
Q
K
H
K
D
H
F
--
R
L
S
--
I
-----------
P
R
-----
K
S
K
--IHRNIRDDE
G
F
I
I
R
H
F
A
G
A
V
C
Y
E
T
T
Q
F
V
E
K
N
N
D
A
L
H
M
S
L
E
S
L
I
C
E
S
R
D
-
K
F
I
R
E
L
F
E
------------------------------------
L
S
F
I
------------
S
V
G
N
K
F
K
T
Q
L
N
L
L
L
D
K
L
R
S
T
G
A
S
F
I
R
C
I
K
P
N
L
K
M
T
S
H
H
F
E
G
A
Q
I
L
S
Q
L
Q
C
S
G
M
V
S
V
L
D
L
M
Q
G
G
F
P
S
R
A
S
F
H
E
L
Y
N
M
Y
KK
Y
M
P
D
K
L
A
-
R
L
D
P
R
L
F
--
C
K
A
L
F
-
K
A
L
G
L
N
E
I
--
D
---
Y
K
F
G
L
T
K
V
F
F
R
P
G
K
F
A
E
F
D
Q
I
M
K
S
D
P
-
D
H
L
A
-
E
L
V
K
R
V
N
H
W
L
I
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
76
PsiBlast_CBE
72.74
31%
-88
- C2 -
2VB6
1
MYO6_PIG
A:
[48-770]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
P
A
E
E
D
S
K
K
D
V
E
D
N
-
C
S
L
M
Y
L
N
E
A
T
L
L
H
N
I
K
V
R
Y
S
K
-
D
R
I
Y
T
Y
V
A
N
I
L
I
A
V
N
P
Y
F
D
I
P
K
I
Y
S
S
E
T
I
K
S
Y
Q
G
K
S
L
G
T
M
P
P
H
V
F
A
I
A
D
K
A
F
R
D
M
K
V
L
K
L
S
Q
S
I
I
V
S
G
E
S
G
A
G
K
T
E
N
T
K
F
V
L
R
Y
L
-
T
-
E
S
Y
G
---
T
G
Q
----
D
I
D
D
R
I
V
E
A
N
P
L
L
E
A
F
G
N
A
K
T
V
R
N
N
N
S
S
R
F
G
K
F
V
E
I
H
F
N
E
K
S
S
V
V
G
G
F
V
S
H
Y
L
L
E
K
S
R
I
C
V
Q
G
K
E
E
R
N
Y
H
I
F
Y
R
L
C
A
G
A
S
-------
E
D
I
R
E
---
R
L
H
L
S
S
P
D
N
F
R
Y
L
----------PL
L
D
D
H
G
D
F
I
R
----------
M
C
T
A
M
K
K
------
I
G
L
D
D
E
E
K
L
D
L
F
R
V
V
A
G
V
L
H
L
G
N
I
D
F
----------------
S
T
Q
A
L
E
Y
C
A
E
L
L
G
-
L
D
Q
D
D
L
R
V
S
L
T
T
-----------------
P
L
K
V
E
Q
A
N
N
A
R
D
A
L
A
K
T
V
Y
S
H
L
F
D
H
V
V
N
R
V
N
Q
C
F
-
P
F
E
T
-----
S
S
Y
F
I
G
V
L
D
I
A
G
F
E
Y
F
E
H
N
S
F
E
Q
F
C
I
N
Y
C
N
E
K
L
Q
Q
F
F
N
E
R
I
L
K
E
E
Q
E
L
Y
Q
K
E
G
L
G
-----
Y
V
-
D
N
Q
D
C
I
D
L
I
E
-
A
R
L
V
G
I
L
D
I
L
D
E
E
N
R
L
P
Q
P
S
D
Q
H
F
T
S
A
V
H
Q
K
H
K
D
H
F
--
R
L
S
--
I
-----------
P
R
-----
K
S
K
L
A
I
H
R
N
IRDDE
G
F
I
I
R
H
F
A
G
A
V
C
Y
E
T
T
Q
F
V
E
K
N
N
D
A
L
H
M
S
L
E
S
L
I
C
E
S
R
D
-
K
F
I
R
E
L
F
E
---
S
----------------------------------
F
I
------------
S
V
G
N
K
F
K
T
Q
L
N
L
L
L
D
K
L
R
S
T
G
A
S
F
I
R
C
I
K
P
N
L
K
M
T
S
H
H
F
E
G
A
Q
I
L
S
Q
L
Q
C
S
G
M
V
S
V
L
D
L
M
Q
G
G
F
P
S
R
A
S
F
H
E
L
Y
N
M
Y
KK
Y
M
P
D
K
L
A
-
R
L
D
P
R
L
F
--
C
K
A
L
F
-
K
A
L
G
L
N
E
I
--
D
---
Y
K
F
G
L
T
K
V
F
F
R
P
G
K
F
A
E
F
D
Q
I
M
K
S
D
P
-
D
H
L
A
-
E
L
V
K
R
V
N
H
W
L
I
C
S
R
W
K
K
V
Q
W
C
S
L
S
V
I
K
L
K
N
---
K
I
K
---
Y
R
A
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
75
PsiBlast_CBE
72.72
31%
-83
- C2 -
4DBQ
1
MYO6_PIG
A:
[48-770]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
P
A
E
E
D
S
K
K
D
V
E
D
N
-
C
S
L
M
Y
L
N
E
A
T
L
L
H
N
I
K
V
R
Y
S
K
-
D
R
I
Y
T
Y
V
A
N
I
L
I
A
V
N
P
Y
F
D
I
P
K
I
Y
S
S
E
T
I
K
S
Y
Q
G
K
S
L
G
T
M
P
P
H
V
F
A
I
A
D
K
A
F
R
D
M
K
V
L
K
L
S
Q
S
I
I
V
S
G
E
S
G
A
G
K
T
E
N
T
K
F
V
L
R
Y
L
-
T
-
E
S
Y
G
---
T
G
Q
----
D
I
Y
D
R
I
V
E
A
N
P
L
L
E
A
F
G
N
A
K
T
V
R
N
N
N
S
S
R
F
G
K
F
V
E
I
H
F
N
E
K
S
S
V
V
G
G
F
V
S
H
Y
L
L
E
K
S
R
I
C
V
Q
G
K
E
E
R
N
Y
H
I
F
Y
R
L
C
A
G
A
S
-------
E
D
I
R
E
---
R
L
H
L
S
S
P
D
N
F
R
Y
L
-
N
R
------
D
PL
L
D
D
H
G
D
F
I
R
----------
M
C
T
A
M
K
K
------
I
G
L
D
D
E
E
K
L
D
L
F
R
V
V
A
G
V
L
H
L
G
N
I
D
F
---------
C
N
L
K
N
-
K
S
T
Q
A
L
E
Y
C
A
E
L
L
G
-
L
D
Q
D
D
L
R
V
S
L
T
T
R
V
M
-------------
V
P
L
K
V
E
Q
A
N
N
A
R
D
A
L
A
K
T
V
Y
S
H
L
F
D
H
V
V
N
R
V
N
Q
C
F
-
P
F
E
T
-----
S
S
Y
F
I
G
V
L
D
I
A
G
F
E
Y
F
E
H
N
S
F
E
Q
F
C
I
N
Y
C
N
E
K
L
Q
Q
F
F
N
E
R
I
L
K
E
E
Q
E
L
Y
Q
K
E
G
L
G
V
N
E
V
H
Y
V
-
D
N
Q
D
C
I
D
L
I
E
-
A
R
L
V
G
I
L
D
I
L
D
E
E
N
R
L
P
Q
P
S
D
Q
H
F
T
S
A
V
H
Q
K
H
K
D
H
F
--
R
L
S
--
I
-----------
P
R
-----
K
S
K
L
A
I
H
R
N
IRDDE
G
F
I
I
R
H
F
A
G
A
V
C
Y
E
T
T
Q
F
V
E
K
N
N
D
A
L
H
M
S
L
E
S
L
I
C
E
S
R
D
-
K
F
I
R
E
L
F
E
---
S
--------------------------------
L
S
F
I
------------
S
V
G
N
K
F
K
T
Q
L
N
L
L
L
D
K
L
R
S
T
G
A
S
F
I
R
C
I
K
P
N
L
K
M
T
S
H
H
F
E
G
A
Q
I
L
S
Q
L
Q
C
S
G
M
V
S
V
L
D
L
M
Q
G
G
F
P
S
R
A
S
F
H
E
L
Y
N
M
Y
KK
Y
M
P
D
K
L
A
-
R
L
D
P
R
L
F
--
C
K
A
L
F
-
K
A
L
G
L
N
E
I
--
D
---
Y
K
F
G
L
T
K
V
F
F
R
P
G
K
F
A
E
F
D
Q
I
M
K
S
D
P
-
D
H
L
A
-
E
L
V
K
R
V
N
H
W
L
I
C
S
R
W
K
K
V
Q
W
C
S
L
S
V
I
K
L
K
N
---
K
I
K
---
Y
R
A
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
77
PsiBlast_CBE
72.50
31%
-89
- C2 -
2VAS
1
MYO6_PIG
A:
[48-770]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
P
A
E
E
D
S
K
K
D
V
E
D
N
-
C
S
L
M
Y
L
N
E
A
T
L
L
H
N
I
K
V
R
Y
S
K
-
D
R
I
Y
T
Y
V
A
N
I
L
I
A
V
N
P
Y
F
D
I
P
K
I
Y
S
S
E
T
I
K
S
Y
Q
G
K
S
L
G
T
M
P
P
H
V
F
A
I
A
D
K
A
F
R
D
M
K
V
L
K
L
S
Q
S
I
I
V
S
G
E
S
G
A
G
K
T
E
N
T
K
F
V
L
R
Y
L
-
T
-
E
S
Y
G
---
T
G
Q
----
D
I
D
D
R
I
V
E
A
N
P
L
L
E
A
F
G
N
A
K
T
V
R
N
N
N
S
S
R
F
G
K
F
V
E
I
H
F
N
E
K
S
S
V
V
G
G
F
V
S
H
Y
L
L
E
K
S
R
I
C
V
Q
G
K
E
E
R
N
Y
H
I
F
Y
R
L
C
A
G
A
S
-------
E
D
I
R
E
---
R
L
H
L
S
S
P
D
N
F
R
Y
L
-
N
--------PL
L
D
D
H
G
D
F
I
R
----------
M
C
T
A
M
K
K
------
I
G
L
D
D
E
E
K
L
D
L
F
R
V
V
A
G
V
L
H
L
G
N
I
D
F
----------------
S
T
Q
A
L
E
Y
C
A
E
L
L
G
-
L
D
Q
D
D
L
R
V
S
L
T
T
R
----------------
P
L
K
V
E
Q
A
N
N
A
R
D
A
L
A
K
T
V
Y
S
H
L
F
D
H
V
V
N
R
V
N
Q
C
F
-
P
F
E
T
-----
S
S
Y
F
I
G
V
L
D
I
A
G
F
E
Y
F
E
H
N
S
F
E
Q
F
C
I
N
Y
C
N
E
K
L
Q
Q
F
F
N
E
R
I
L
K
E
E
Q
E
L
Y
Q
K
E
G
L
G
V
N
E
V
H
Y
V
-
D
N
Q
D
C
I
D
L
I
E
-
A
R
L
V
G
I
L
D
I
L
D
E
E
N
R
L
P
Q
P
S
D
Q
H
F
T
S
A
V
H
Q
K
H
K
D
H
F
--
R
L
S
--
I
-----------
P
R
-----
K
S
K
L
A
I
H
R
N
IRDDE
G
F
I
I
R
H
F
A
G
A
V
C
Y
E
T
T
Q
F
V
E
K
N
N
D
A
L
H
M
S
L
E
S
L
I
C
E
S
R
D
-
K
F
I
R
E
L
F
E
---
S
----------------------------------
F
I
------------
S
V
G
N
K
F
K
T
Q
L
N
L
L
L
D
K
L
R
S
T
G
A
S
F
I
R
C
I
K
P
N
L
K
M
T
S
H
H
F
E
G
A
Q
I
L
S
Q
L
Q
C
S
G
M
V
S
V
L
D
L
M
Q
G
G
F
P
S
R
A
S
F
H
E
L
Y
N
M
Y
KK
Y
M
P
D
K
L
A
-
R
L
D
P
R
L
F
--
C
K
A
L
F
-
K
A
L
G
L
N
E
I
--
D
---
Y
K
F
G
L
T
K
V
F
F
R
P
G
K
F
A
E
F
D
Q
I
M
K
S
D
P
-
D
H
L
A
-
E
L
V
K
R
V
N
H
W
L
I
C
S
R
W
K
K
V
Q
W
C
S
L
S
V
I
K
L
K
N
---
K
I
K
---
Y
R
A
E
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
78
PsiBlast_CBE
71.46
31%
-84
- C2 -
4PJJ
3
?
A:
[48-770]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
P
A
E
E
D
S
K
K
D
V
E
D
N
-
C
S
L
M
Y
L
N
E
A
T
L
L
H
N
I
K
V
R
Y
S
K
-
D
R
I
Y
T
Y
V
A
N
I
L
I
A
V
N
P
Y
F
D
I
P
K
I
Y
S
S
E
T
I
K
S
Y
Q
G
K
S
L
G
T
M
P
P
H
V
F
A
I
A
D
K
A
F
R
D
M
K
V
L
K
L
S
Q
S
I
I
V
S
G
E
S
G
A
G
K
T
E
N
T
K
F
V
L
R
Y
L
-
T
-
E
S
Y
G
---
T
G
Q
----
D
I
D
D
R
I
V
E
A
N
P
L
L
E
A
F
G
N
A
K
T
V
R
N
N
N
S
S
R
F
G
K
F
V
E
I
H
F
N
E
K
S
S
V
V
G
G
F
V
S
H
Y
L
L
E
K
S
R
I
C
V
Q
G
K
E
E
R
N
Y
H
I
F
Y
R
L
C
A
G
A
S
-------
E
D
I
R
E
---
R
L
H
L
S
S
P
D
N
F
R
Y
L
-
N
--------PL
L
D
D
H
G
D
F
I
R
----------
M
C
T
A
M
K
K
------
I
G
L
D
D
E
E
K
L
D
L
F
R
V
V
A
G
V
L
H
L
G
N
I
D
F
E
E
-------
C
N
L
K
N
-
K
S
T
Q
A
L
E
Y
C
A
E
L
L
G
-
L
D
Q
D
D
L
R
V
S
L
T
T
M
V
---------------
P
L
K
V
E
Q
A
N
N
A
R
D
A
L
A
K
T
V
Y
S
H
L
F
D
H
V
V
N
R
V
N
Q
C
F
-
P
F
E
T
-----
S
S
Y
F
I
G
V
L
D
I
A
G
F
E
Y
F
E
H
N
S
F
E
Q
F
C
I
N
Y
C
N
E
K
L
Q
Q
F
F
N
E
R
I
L
K
E
E
Q
E
L
Y
Q
K
E
G
L
G
V
N
E
V
H
Y
V
-
D
N
Q
D
C
I
D
L
I
E
-
A
R
L
V
G
I
L
D
I
L
D
E
E
N
R
L
P
Q
P
S
D
Q
H
F
T
S
A
V
H
Q
K
H
K
D
H
F
--
R
L
S
--
I
-----------
P
R
-----
K
S
K
L
A
I
H
R
N
IRDDE
G
F
I
I
R
H
F
A
G
A
V
C
Y
E
T
T
Q
F
V
E
K
N
N
D
A
L
H
M
S
L
E
S
L
I
C
E
S
R
D
-
K
F
I
R
E
L
F
E
---
S
S
-------------------------------
L
S
F
I
------------
S
V
G
N
K
F
K
T
Q
L
N
L
L
L
D
K
L
R
S
T
G
A
S
F
I
R
C
I
K
P
N
L
K
M
T
S
H
H
F
E
G
A
Q
I
L
S
Q
L
Q
C
S
G
M
V
S
V
L
D
L
M
Q
G
G
F
P
S
R
A
S
F
H
E
L
Y
N
M
Y
KK
Y
M
P
D
K
L
A
-
R
L
D
P
R
L
F
--
C
K
A
L
F
-
K
A
L
G
L
N
E
I
--
D
---
Y
K
F
G
L
T
K
V
F
F
R
P
G
K
F
A
E
F
D
Q
I
M
K
S
D
P
-
D
H
L
A
-
E
L
V
K
R
V
N
H
W
L
I
C
S
R
W
K
K
V
Q
W
C
S
L
S
V
I
K
L
K
N
---
K
I
K
---
Y
R
A
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
10
PsiBlast_PDB
70.63
35%
-91
- C2 -
1MND
1
MYS2_DICDI
A:
[89-690]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
D
M
S
E
L
S
Y
L
N
E
P
A
V
F
H
N
L
R
V
R
Y
N
Q
-
D
L
I
Y
T
Y
S
G
L
F
L
V
A
V
N
P
F
K
R
I
-
P
I
Y
T
Q
E
M
V
D
I
F
K
G
R
R
R
N
E
V
A
P
H
I
F
A
I
S
D
V
A
Y
R
S
M
L
D
D
R
Q
N
Q
S
L
L
I
T
G
E
S
G
A
G
K
T
E
N
T
K
K
V
I
Q
Y
L
-
A
S
V
A
G
-----------
V
L
E
Q
Q
I
L
Q
A
N
P
I
L
E
A
F
G
N
A
K
T
T
R
N
N
N
S
S
R
F
G
K
F
I
E
I
Q
F
N
N
A
G
F
I
S
G
A
S
I
Q
S
Y
L
L
E
K
S
R
V
V
F
Q
S
E
T
E
R
N
Y
H
I
F
Y
Q
L
L
A
G
A
T
-------
A
E
E
K
K
A
-
L
H
L
A
G
P
E
S
F
N
Y
L
-
N
-
Q
S
G
C
-
V
D
I
K
--
G
V
S
D
E
D
-------------
E
F
K
I
T
R
Q
A
--
M
D
I
V
G
F
S
Q
E
E
Q
M
S
I
F
K
I
I
A
G
I
L
H
L
G
N
I
K
F
E
K
G
A
G
E
G
A
V
L
K
D
K
T
-----
A
L
N
A
A
S
T
V
F
G
-
V
N
P
S
V
L
E
K
A
L
M
E
P
R
I
L
A
-----
G
R
D
L
V
A
Q
H
L
N
V
E
K
S
S
S
S
R
D
A
L
V
K
A
L
Y
G
R
L
F
L
W
L
V
K
K
I
N
N
V
L
------
C
S
-
R
A
A
Y
F
I
G
V
L
D
I
S
G
F
E
I
F
K
V
N
S
F
E
Q
L
C
I
N
Y
T
N
E
K
L
Q
Q
F
F
N
H
H
M
----------------------
D
S
Q
A
T
I
D
L
I
D
G
R
Q
P
P
G
I
L
A
L
L
D
E
Q
S
V
F
P
N
A
T
D
N
T
L
I
T
----
K
L
H
S
H
F
--
S
K
K
NA
K
Y
E
--------
E
P
R
-----
F
S
K
T
E
----------
F
G
V
T
H
Y
A
G
Q
V
M
Y
E
I
Q
D
W
L
E
K
N
K
D
P
L
Q
Q
D
L
E
L
C
F
K
D
S
S
D
-
N
V
V
T
K
L
F
N
D
P
-----
N
I
A
-----------------
S
R
------
F
I
---------------
T
V
A
A
Q
Y
K
E
Q
L
A
S
L
M
A
T
L
E
T
T
N
P
H
F
V
R
C
I
I
P
N
N
K
Q
L
P
A
K
L
E
D
K
V
V
L
D
Q
L
R
C
N
G
V
L
E
-
I
R
I
T
R
K
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
83
PsiBlast_CBE
70.41
31%
-82
- C2 -
4PK4
1
?
A:
[48-787]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
P
A
E
E
D
S
K
K
D
V
E
D
N
-
C
S
L
M
Y
L
N
E
A
T
L
L
H
N
I
K
V
R
Y
S
K
-
D
R
I
Y
T
Y
V
A
N
I
L
I
A
V
N
P
Y
F
D
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