@TOME V2.3
(Nov 2016)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : NIM1_HUMAN: (2015-10-15 )
MTAVYMNGGGLVNPHYARWDRRDSVESGCQTESSKEGEEGQPRQLTPFEKLTQDMSQDEKVVREITLGKRIGFYRIRGEIGSGNFSQVKLGIHSLTKEKVAIKILDKTKLDQKTQRLLSREISSMEKLHHPNIIRLYEVVETLSKLHLVMEYAGGGELFGKISTEGKLSEPESKLIFSQIVSAVKHMHENQIIHRDLKAENVFYTSNTCVKVGDFGFSTVSKKGEMLNTFCGSPPYAAPELFRDEHYIGIYVDIWALGVLLYFMVTGTMPFRAETVAKLKKSILEGTYSVPPHVSEPCHRLIRGVLQQIPTERYGIDCIMNDEWMQGVPYPTPLEPFQLDPKHLSETSTLKEEENEVKSTLEHLGITEEHIRNNQGRDARSSITGVYRIILHRVQRKKALESVPVMMLPDPKERDLKKGSRVYRGIRHTSKFCSIL
Atome Classification :
(36 SA)
.........10........20........30........40........50........60........70.......-.--80........90........100.......-110-....-.---..120.....-..130.......140----.......150.......160.....-..170.......180.......190.......200....---...210.......220--........230.......240.......250.---........260.......270.-...----...280.......290----.----.---......300.......310.......320..-.-....-330...---..-..340....-...350.......360.......370..-.....380.......390.......400.......410.......420.......430....
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
M
T
A
V
Y
MNGGGLVNP
H
Y
ARWDRRDSVESGCQTESSKEGEEGQPRQLT
P
F
E
K
L
T
Q
D
M
S
Q
D
E
K
V
V
R
E
I
TLGKR
I
G
F
Y
R
I
R
G
-E--IGSG
N
F
S
Q
V
K
L
G
I
H
S
LTKE
K
V
A
I
K
I
LDKTK-L
D
Q
-
K
T
Q
R
-
L
---
L
S
R
E
I
S
S
M
E
K
-LHHP
N
I
I
R
L
Y
E
V
V
E
T
----
L
S
K
L
H
L
V
MEYAGGG
E
L
F
G
K
ISTEGK-LSE
P
E
S
K
L
I
F
S
Q
I
V
S
A
V
K
H
M
H
EN
Q
I
I
H
R
DLKAE
N
V
F
YTS---N
T
C
V
K
VGDFG
F
S
T
V
S---KK
G
E
M
L
N
T
FCGSPPYA
A
P
E
L
FRDE
H
Y
I
G
I
--
Y
---
V
D
I
W
A
L
G
V
L
L
Y
F
M
VTGTMPF
R
A
-
E
T
V
----
A
K
L
K
K
S
I
LEGTYSV-P----P----H---V
S
E
P
C
H
R
L
I
R
G
V
L
Q
QIPTERYG
I
D
C
I
MN
D
E
W
-M-QGVP-YPTPLE---PF-QL
D
P
K
HLSE-TST
L
K
E
E
E
N
E
V
K
S
T
L
E
HLGI
T
E
E
H
IRNN-QGR
D
A
R
S
S
I
T
G
V
Y
R
I
I
L
H
R
V
Q
R
K
K
A
L
E
SV
P
V
M
MLPDP
K
E
R
D
L
K
K
G
S
R
V
Y
R
G
I
R
H
T
S
K
F
CSIL
11
PsiBlast_PDB
82.11
37%
-102
- C1 -
4RER
2
AAPK1_HUMAN
A:
[4-320]
---------------------------------------------------------------------
K
I
G
H
Y
I
L
G
D
-
T
--
L
G
V
G
T
F
G
K
V
K
V
G
K
H
E
L
T
G
H
K
V
A
V
K
I
L
N
R
Q
K
-
I
R
S
L
D
V
V
G
-
K
---
I
R
R
E
I
Q
N
L
K
L
-
F
R
H
P
H
I
I
K
L
Y
Q
V
I
S
T
----
P
S
D
I
F
M
V
M
E
Y
V
S
G
G
E
L
F
D
Y
I
C
K
N
G
R
-
L
D
E
K
E
S
R
R
L
F
Q
Q
I
L
S
G
V
D
Y
C
H
R
H
M
V
V
H
R
D
L
K
P
E
N
V
L
L
D
A
---
H
M
N
A
K
I
A
D
F
G
L
S
N
M
M
---
S
D
G
E
F
L
R
T
S
C
G
S
P
N
Y
A
A
P
E
V
I
S
G
R
L
Y
A
G
P
--
E
---
V
D
I
W
S
S
G
V
I
L
Y
A
L
L
C
G
T
L
P
F
D
D
-
D
H
V
----
P
T
L
F
K
K
I
C
D
G
I
F
Y
T
-
P
----
Q
----
Y
---
L
N
P
S
V
I
S
L
L
K
H
M
L
Q
V
D
P
M
K
R
A
S
I
K
D
I
R
E
H
E
W
-
F
K
Q
D
L
P
K
Y
L
F
P
E
D
---
P
---------
S
Y
-
S
----
D
D
E
-
A
L
K
E
V
C
E
K
F
E
C
S
E
E
E
V
L
S
C
L
Y
N
R
N
H
Q
D
P
L
A
V
A
Y
H
L
I
I
D
N
R
R
I
M
N
E
A
K
D
F
Y
L
A
T
S
P
P
D
D
H
H
L
T
R
P
H
P
E
R
V
P
F
L
V
A
E
T
P
R
K
A
K
W
125
HHSearch
80.34
36%
-94
- C1 -
4BKY
1
MELK_HUMAN
A:
[9-331]
----------------------------------------------------------------------
L
K
Y
Y
E
L
H
E
-
T
--
I
G
T
G
G
F
A
K
V
K
L
A
C
H
I
L
T
G
E
M
V
A
I
K
I
M
D
K
N
T
-
L
---
D
-
L
P
-
R
---
I
K
T
E
I
E
A
L
K
N
-
L
R
H
Q
H
I
C
Q
L
Y
H
V
L
E
T
----
A
N
K
I
F
M
V
L
E
Y
C
P
G
G
E
L
F
D
Y
I
I
S
Q
D
R
-
L
S
E
E
E
T
R
V
V
F
R
Q
I
V
S
A
V
A
Y
V
H
S
Q
G
Y
A
H
R
D
L
K
P
E
N
L
L
F
D
E
---
Y
H
K
L
K
L
I
D
F
G
L
C
A
----------------
S
L
A
Y
A
A
P
E
L
I
Q
G
K
---
G
S
--
E
---
A
D
V
W
S
M
G
I
L
L
Y
V
L
M
C
G
F
L
P
F
D
D
-
D
N
V
----
M
A
L
Y
K
K
I
M
R
G
K
Y
D
V
-
P
----
K
----
W
---
L
S
P
S
S
I
L
L
L
Q
Q
M
L
Q
V
D
P
K
K
R
I
S
M
K
N
L
L
N
H
P
W
-
I
-
M
Q
D
--
Y
N
Y
P
V
E
---
W
Q
-
S
K
N
P
F
------
I
H
L
--
D
D
D
C
V
T
E
L
S
V
H
H
R
N
N
R
Q
T
M
E
D
L
-
I
S
L
W
Q
Y
D
H
L
T
A
T
Y
L
L
L
L
A
K
K
A
R
G
K
P
V
R
L
R
---------------------------------
24
PsiBlast_CBE
78.65
40%
-110
- C1 -
3AQV
1
AAPK2_HUMAN
A:
[9-266]
---------------------------------------------------------------------
K
I
G
H
Y
V
L
G
D
-
T
--
L
G
V
G
T
F
G
K
V
K
I
G
E
H
Q
L
T
G
H
K
V
A
V
K
I
L
N
R
Q
K
-
I
R
S
L
D
V
V
G
-
K
---
I
K
R
E
I
Q
N
L
K
L
-
F
R
H
P
H
I
I
K
L
Y
Q
V
I
S
T
----
P
T
D
F
F
M
V
M
E
Y
V
S
G
G
E
L
F
D
Y
I
C
K
H
G
R
-
V
E
E
M
E
A
R
R
L
F
Q
Q
I
L
S
A
V
D
Y
C
H
R
H
M
V
V
H
R
D
L
K
P
E
N
V
L
L
D
A
---
H
M
N
A
K
I
A
D
F
G
L
S
N
M
M
---
S
D
G
E
F
L
------
P
N
Y
A
A
P
E
V
I
S
G
R
L
Y
A
G
P
--
E
---
V
D
I
W
S
C
G
V
I
L
Y
A
L
L
C
G
T
L
P
F
D
D
-
E
H
V
----
P
T
L
F
K
K
I
R
G
G
V
F
Y
I
-
P
----
E
----
Y
---
L
N
R
S
V
A
T
L
L
M
H
M
L
Q
V
D
P
L
K
R
A
T
I
K
D
I
R
E
H
E
W
-
F
-
K
Q
D
L
-
P
S
Y
L
F
P
---
E
-------------------------------------------------------------------------------------------------------
19
PsiBlast_PDB
78.18
39%
-114
- C1 -
4BKZ
1
MELK_HUMAN
A:
[9-293]
----------------------------------------------------------------------
L
K
Y
Y
E
L
H
E
-
T
--
I
G
T
G
--
A
K
V
K
L
A
C
H
I
L
T
G
E
M
V
A
I
K
I
M
D
K
N
T
-
L
----
L
P
R
-
I
----
K
T
E
I
E
A
L
K
N
-
L
R
H
Q
H
I
C
Q
L
Y
H
V
L
E
T
----
A
N
K
I
F
M
V
L
E
Y
C
P
G
G
E
L
F
D
Y
I
I
S
Q
D
R
-
L
S
E
E
E
T
R
V
V
F
R
Q
I
V
S
A
V
A
Y
V
H
S
Q
G
Y
A
H
R
D
L
K
P
E
N
L
L
F
D
E
---
Y
H
K
L
K
L
I
D
F
G
L
C
A
----------------
S
L
A
Y
A
A
P
E
L
I
Q
G
----
G
S
--
E
---
A
D
V
W
S
M
G
I
L
L
Y
V
L
M
C
G
F
L
P
F
D
D
-
D
N
V
----
M
A
L
Y
K
K
I
M
R
G
K
Y
D
V
-
P
----
K
----
W
---
L
S
P
S
S
I
L
L
L
Q
Q
M
L
Q
V
D
P
K
K
R
I
S
M
K
N
L
L
N
H
P
W
I
M
-
Q
D
Y
N
-
Y
P
V
E
W
Q
SKN
P
F
I
H
L
D
D
D
C
V
T
E
-
L
S
V
H
H
R
N
N
R
Q
T
M
E
D
L
I
S
L
W
Q
Y
D
H
L
T
A
T
Y
-
L
L
L
L
A
K
K
A
R
G
K
P
V
R
L
R
L
---------------------------------------------
17
PsiBlast_PDB
78.15
39%
-109
- C1 -
4BL1
1
MELK_HUMAN
A:
[9-293]
----------------------------------------------------------------------
L
K
Y
Y
E
L
H
E
-
T
--
I
G
T
G
G
F
A
K
V
K
L
A
C
H
I
L
T
G
E
M
V
A
I
K
I
M
D
K
N
T
-
L
----
L
P
R
-
I
----
K
T
E
I
E
A
L
K
N
-
L
R
H
Q
H
I
C
Q
L
Y
H
V
L
E
T
----
A
N
K
I
F
M
V
L
E
Y
C
P
G
G
E
L
F
D
Y
I
I
S
Q
D
R
-
L
S
E
E
E
T
R
V
V
F
R
Q
I
V
S
A
V
A
Y
V
H
S
Q
G
Y
A
H
R
D
L
K
P
E
N
L
L
F
D
E
---
Y
H
K
L
K
L
I
D
F
G
L
C
A
K
---------------
S
L
A
Y
A
A
P
E
L
I
Q
G
K
---
G
S
--
E
---
A
D
V
W
S
M
G
I
L
L
Y
V
L
M
C
G
F
L
P
F
D
D
-
D
N
V
----
M
A
L
Y
K
K
I
M
R
G
K
Y
D
V
-
P
----
K
----
W
---
L
S
P
S
S
I
L
L
L
Q
Q
M
L
Q
V
D
P
K
K
R
I
S
M
K
N
L
L
N
H
P
W
I
M
-
Q
D
Y
N
-
Y
P
V
E
W
Q
SKN
P
F
I
H
L
D
D
D
C
V
T
E
-
L
S
V
H
H
R
N
N
R
Q
T
M
E
D
L
I
S
L
W
Q
Y
D
H
L
T
A
T
Y
-
L
L
L
L
A
K
K
A
R
G
K
P
V
R
L
R
----------------------------------------------
58
PsiBlast_CBE
76.90
34%
-124
- C1 -
4FG8
1
KCC1A_HUMAN
B:
[20-278]
-------------------------------------------------------------------------
Y
D
F
R
D
-
V
--
L
G
T
G
A
F
S
E
V
I
L
A
E
D
K
R
T
Q
K
L
V
A
I
K
C
I
A
K
------------------
N
E
I
A
V
L
H
K
-
I
K
H
P
N
I
V
A
L
D
D
I
Y
E
S
----
G
G
H
L
Y
L
I
M
Q
L
V
S
G
G
E
L
F
D
R
I
V
E
K
G
F
-
Y
T
E
R
D
A
S
R
L
I
F
Q
V
L
D
A
V
K
Y
L
H
D
L
G
I
V
H
R
D
L
K
P
E
N
L
L
Y
Y
S
LDE
D
S
K
I
M
I
S
D
F
G
----------
G
S
V
L
S
T
A
C
G
T
P
G
Y
V
A
P
E
V
L
A
Q
K
P
Y
-
S
K
--
A
---
V
D
C
W
S
I
G
V
I
A
Y
I
L
L
C
G
Y
P
P
F
Y
D
-
E
N
D
----
A
K
L
F
E
Q
I
L
K
A
E
Y
E
F
D
S
----
P
----
Y
WDD
I
S
D
S
A
K
D
F
I
R
H
L
M
E
K
D
P
E
K
R
F
T
C
E
Q
A
L
Q
H
P
W
-
I
-
A
G
D
T
-
A
L
D
K
N
I
---
H
Q
-
S
V
S
E
Q
I
K
K
N
-
F
A
-----------------------------------------------------------------------------------------
60
PsiBlast_CBE
76.04
34%
-121
- C1 -
4FG7
1
KCC1A_HUMAN
A:
[20-277]
-------------------------------------------------------------------------
Y
D
F
R
D
-
V
--
L
G
T
G
A
F
S
E
V
I
L
A
E
D
K
R
T
Q
K
L
V
A
I
K
C
I
A
-------------
S
---
M
E
N
E
I
A
V
L
H
K
-
I
K
H
P
N
I
V
A
L
D
D
I
Y
E
S
----
G
G
H
L
Y
L
I
M
Q
L
V
S
G
G
E
L
F
D
R
I
V
E
K
G
F
-
Y
T
E
R
D
A
S
R
L
I
F
Q
V
L
D
A
V
K
Y
L
H
D
L
G
I
V
H
R
D
L
K
P
E
N
L
L
Y
Y
S
LDE
D
S
K
I
M
I
S
D
F
G
L
S
K
M
E
---
D
P
G
--------
T
P
G
Y
V
A
P
E
V
L
A
Q
K
---
S
K
--
A
---
V
D
C
W
S
I
G
V
I
A
Y
I
L
L
C
G
Y
P
P
F
Y
D
-
E
N
D
----
A
K
L
F
E
Q
I
L
K
A
E
Y
E
F
D
S
----
P
----
Y
WDD
I
S
D
S
A
K
D
F
I
R
H
L
M
E
K
D
P
E
K
R
F
T
C
E
Q
A
L
Q
H
P
W
-
I
-
A
---------------------------------------------------------------------------------------------------------------------
59
PsiBlast_CBE
71.32
34%
-129
- C1 -
4FG8
1
KCC1A_HUMAN
A:
[20-278]
-------------------------------------------------------------------------
Y
D
F
R
D
-
V
--
L
G
T
G
A
F
S
E
V
I
L
A
E
D
K
R
T
Q
K
L
V
A
I
K
C
I
A
K
E
-----------------
N
E
I
A
V
L
H
K
-
I
K
H
P
N
I
V
A
L
D
D
I
Y
E
S
----
G
G
H
L
Y
L
I
M
Q
L
V
S
G
G
E
L
F
D
R
I
V
E
K
G
F
-
Y
T
E
R
D
A
S
R
L
I
F
Q
V
L
D
A
V
K
Y
L
H
D
L
G
I
V
H
R
D
L
K
P
E
N
L
L
Y
Y
S
LDE
D
S
K
I
M
I
S
D
F
--------------------
T
P
G
Y
V
A
P
E
V
L
A
Q
K
P
Y
-
S
K
--
A
---
V
D
C
W
S
I
G
V
I
A
Y
I
L
L
C
G
Y
P
P
F
Y
D
-
E
N
D
----
A
K
L
F
E
Q
I
L
K
A
E
Y
E
F
D
S
----
P
----
Y
WDD
I
S
D
S
A
K
D
F
I
R
H
L
M
E
K
D
P
E
K
R
F
T
C
E
Q
A
L
Q
H
P
W
-
I
-
A
G
D
T
-
A
L
D
K
N
I
---
H
Q
-
S
V
S
E
Q
I
K
K
N
-
F
A
-----------------------------------------------------------------------------------------
102
PsiBlast_CBE
70.44
35%
-121
- C1 -
2W0J
1
CHK2_HUMAN
A:
[12-279]
-------------------------------------------------------------------------
Y
I
M
S
K
-
T
--
L
G
S
---
G
E
V
K
L
A
F
E
R
K
T
C
K
K
V
A
I
K
I
I
S
K
-------------N--
V
E
T
E
I
E
I
L
K
K
-
L
N
H
P
C
I
I
K
I
K
N
F
F
D
A
-----
E
D
Y
Y
I
V
L
E
L
M
E
G
G
E
L
F
D
K
V
V
G
N
K
R
-
L
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
E
N
G
I
I
H
R
D
L
K
P
E
N
V
L
L
S
S
QEE
D
C
L
I
K
I
T
D
F
G
H
S
K
I
L
-----
T
S
L
M
R
T
L
C
G
T
P
T
Y
L
A
P
E
V
L
V
S
V
G
T
A
G
Y
NR
A
---
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
S
E
H
R
T
Q
----
V
S
L
K
D
Q
I
T
S
G
K
Y
N
F
-
I
----
P
EVWA
E
---
V
S
E
K
A
L
D
L
V
K
K
L
L
V
V
D
P
K
A
R
F
T
T
E
E
A
L
R
H
P
W
-
L
-
Q
D
E
D
-
M
K
R
K
F
Q
---
D
L
-
L
S
E
E
N
E
T
A
L
-
P
Q
-----------------------------------------------------------------------------------------
97
PsiBlast_CBE
68.85
35%
-116
- C1 -
2YIT
1
CHK2_HUMAN
A:
[12-279]
-------------------------------------------------------------------------
Y
I
M
S
K
-
T
--
L
G
S
G
A
C
G
E
V
K
L
A
F
E
R
K
T
C
K
K
V
A
I
K
I
I
S
K
-------------LN-
V
E
T
E
I
E
I
L
K
K
-
L
N
H
P
C
I
I
K
I
K
N
F
F
D
A
-----
E
D
Y
Y
I
V
L
E
L
M
E
G
G
E
L
F
D
K
V
V
G
N
K
R
-
L
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
E
N
G
I
I
H
R
D
L
K
P
E
N
V
L
L
S
S
QEE
D
C
L
I
K
I
T
D
F
G
H
S
K
I
L
---
G
E
T
S
L
M
R
T
L
C
G
T
P
T
Y
L
A
P
E
V
L
V
S
V
G
T
A
G
Y
NR
A
---
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
S
E
H
R
T
Q
----
V
S
L
K
D
Q
I
T
S
G
K
Y
N
F
-
I
----
P
EVWA
E
---
V
S
E
K
A
L
D
L
V
K
K
L
L
V
V
D
P
K
A
R
F
T
T
E
E
A
L
R
H
P
W
-
L
-
Q
D
E
D
-
M
K
R
K
F
Q
---
D
L
-
L
S
E
E
N
E
S
T
A
-
L
P
Q
----------------------------------------------------------------------------------------
100
PsiBlast_CBE
68.58
35%
-119
- C1 -
2YCS
1
CHK2_HUMAN
A:
[12-279]
-------------------------------------------------------------------------
Y
I
M
S
K
-
T
--
L
G
S
---
G
E
V
K
L
A
F
E
R
K
T
C
K
K
V
A
I
K
I
I
S
K
-------------N--
V
E
T
E
I
E
I
L
K
K
-
L
N
H
P
C
I
I
K
I
K
N
F
F
D
A
-----
E
D
Y
Y
I
V
L
E
L
M
E
G
G
E
L
F
D
K
V
V
G
N
K
R
-
L
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
E
N
G
I
I
H
R
D
L
K
P
E
N
V
L
L
S
S
QEE
D
C
L
I
K
I
T
D
F
G
H
S
K
I
L
-----
T
S
L
M
R
T
L
C
G
T
P
T
Y
L
A
P
E
V
L
V
S
V
G
T
A
G
Y
NR
A
---
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
S
E
H
R
T
Q
----
V
S
L
K
D
Q
I
T
S
G
K
Y
N
F
-
I
----
P
EVWA
E
---
V
S
E
K
A
L
D
L
V
K
K
L
L
V
V
D
P
K
A
R
F
T
T
E
E
A
L
R
H
P
W
-
L
-
Q
D
E
D
-
M
K
R
K
F
Q
---
D
L
-
L
S
E
E
N
E
S
T
A
-
L
P
Q
----------------------------------------------------------------------------------------
40
PsiBlast_CBE
67.97
36%
-106
- C1 -
4CZT
4
CIPKN_ARATH
D:
[9-269]
---------------------------------------------------------------------
R
V
G
K
Y
E
L
G
R
-
T
--
L
G
E
G
T
F
A
K
V
K
F
A
R
N
V
E
N
G
D
N
V
A
I
K
V
I
D
K
E
K
V
L
K
N
-
K
M
I
A
-
Q
---
I
K
R
E
I
S
T
M
K
L
-
I
K
H
P
N
V
I
R
M
F
E
V
M
A
S
----
K
T
K
I
Y
F
V
L
E
F
V
T
G
G
E
L
F
D
K
I
S
S
N
G
R
-
L
K
E
D
E
A
R
K
Y
F
Q
Q
L
I
N
A
V
D
Y
C
H
S
R
G
V
Y
H
R
D
L
K
P
E
N
L
L
L
D
A
---
N
G
A
L
K
V
S
D
F
G
L
S
A
L
P
QQV
R
E
D
G
L
L
H
T
T
C
G
T
P
N
Y
V
A
P
E
V
I
N
N
K
G
Y
D
G
A
--
K
---
A
D
L
W
S
C
G
V
I
L
F
V
L
M
A
G
Y
L
P
F
E
D
-
S
N
L
----
T
S
L
Y
K
K
I
F
K
A
E
F
T
C
-
P
----
P
----
W
---
F
S
A
S
A
K
K
L
I
K
R
I
L
D
P
N
P
A
T
R
I
T
F
A
E
V
I
E
N
E
W
-
F
-
K
K
G
Y
-
K
A
P
K
F
E
---
N
A
-
D
V
S
L
D
D
V
D
A
-
I
F
D
D
S
N
L
V
V
E
R
R
E
------------------------------------------------------------------------------
96
PsiBlast_CBE
67.56
35%
-119
- C1 -
2YCR
1
CHK2_HUMAN
A:
[12-279]
-------------------------------------------------------------------------
Y
I
M
S
K
-
T
--
L
G
S
---
G
E
V
K
L
A
F
E
R
K
T
C
K
K
V
A
I
K
I
I
S
K
-------------N--
V
E
T
E
I
E
I
L
K
K
-
L
N
H
P
C
I
I
K
I
K
N
F
F
D
A
-----
E
D
Y
Y
I
V
L
E
L
M
E
G
G
E
L
F
D
K
V
V
G
N
K
R
-
L
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
E
N
G
I
I
H
R
D
L
K
P
E
N
V
L
L
S
S
QEE
D
C
L
I
K
I
T
D
F
G
H
S
K
I
L
---
G
E
T
S
L
M
R
T
L
C
G
T
P
T
Y
L
A
P
E
V
L
V
S
V
G
T
A
G
Y
NR
A
---
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
S
E
H
R
T
Q
----
V
S
L
K
D
Q
I
T
S
G
K
Y
N
F
-
I
----
P
EVWA
E
---
V
S
E
K
A
L
D
L
V
K
K
L
L
V
V
D
P
K
A
R
F
T
T
E
E
A
L
R
H
P
W
-
L
-
Q
D
E
D
-
M
K
R
K
F
Q
---
D
L
-
L
S
E
E
N
E
S
T
A
-
K
P
Q
----------------------------------------------------------------------------------------
42
PsiBlast_CBE
67.41
36%
-108
- C1 -
4CZT
2
CIPKN_ARATH
B:
[9-269]
---------------------------------------------------------------------
R
V
G
K
Y
E
L
G
R
-
T
--
L
G
E
G
T
F
A
K
V
K
F
A
R
N
V
E
N
G
D
N
V
A
I
K
V
I
D
K
E
K
V
L
K
N
-
K
M
I
A
-
Q
---
I
K
R
E
I
S
T
M
K
L
-
I
K
H
P
N
V
I
R
M
F
E
V
M
A
S
----
K
T
K
I
Y
F
V
L
E
F
V
T
G
G
E
L
F
D
K
I
S
S
N
G
R
-
L
K
E
D
E
A
R
K
Y
F
Q
Q
L
I
N
A
V
D
Y
C
H
S
R
G
V
Y
H
R
D
L
K
P
E
N
L
L
L
D
A
---
N
G
A
L
K
V
S
D
F
G
L
S
A
L
P
QQV
R
E
D
G
L
L
H
T
T
C
G
T
P
N
Y
V
A
P
E
V
I
N
N
K
G
Y
D
G
A
--
K
---
A
D
L
W
S
C
G
V
I
L
F
V
L
M
A
G
Y
L
P
F
E
D
-
S
N
L
----
T
S
L
Y
K
K
I
F
K
A
E
F
T
C
-
P
----
P
----
W
---
F
S
A
S
A
K
K
L
I
K
R
I
L
D
P
N
P
A
T
R
I
T
F
A
E
V
I
E
N
E
W
-
F
-
K
K
G
Y
-
K
A
P
K
F
E
---
D
D
-
V
D
A
I
F
D
D
S
G
--------------------------------------------------------------------------------------------
43
PsiBlast_CBE
67.21
36%
-102
- C1 -
4CZT
3
CIPKN_ARATH
A:
[9-269]
---------------------------------------------------------------------
R
V
G
K
Y
E
L
G
R
-
T
--
L
G
E
G
T
F
A
K
V
K
F
A
R
N
V
E
N
G
D
N
V
A
I
K
V
I
D
K
E
K
V
L
K
N
-
K
M
I
A
-
Q
---
I
K
R
E
I
S
T
M
K
L
-
I
K
H
P
N
V
I
R
M
F
E
V
M
A
S
----
K
T
K
I
Y
F
V
L
E
F
V
T
G
G
E
L
F
D
K
I
S
S
N
G
R
-
L
K
E
D
E
A
R
K
Y
F
Q
Q
L
I
N
A
V
D
Y
C
H
S
R
G
V
Y
H
R
D
L
K
P
E
N
L
L
L
D
A
---
N
G
A
L
K
V
S
D
F
G
L
S
A
L
P
QQV
R
E
D
G
L
L
H
T
T
C
G
T
P
N
Y
V
A
P
E
V
I
N
N
K
G
Y
D
G
A
--
K
---
A
D
L
W
S
C
G
V
I
L
F
V
L
M
A
G
Y
L
P
F
E
D
-
S
N
L
----
T
S
L
Y
K
K
I
F
K
A
E
F
T
C
-
P
----
P
----
W
---
F
S
A
S
A
K
K
L
I
K
R
I
L
D
P
N
P
A
T
R
I
T
F
A
E
V
I
E
N
E
W
-
F
-
K
K
G
Y
-
K
A
P
K
F
E
---
N
V
-
S
L
D
D
V
D
A
I
F
-
D
D
S
G
E
S
-------------------------------------------------------------------------------------
46
PsiBlast_CBE
67.18
36%
-108
- C1 -
4CZU
3
CIPKN_ARATH
B:
[9-269]
---------------------------------------------------------------------
R
V
G
K
Y
E
L
G
R
-
T
--
L
G
E
G
T
F
A
K
V
K
F
A
R
N
V
E
N
G
D
N
V
A
I
K
V
I
D
K
E
K
V
L
K
N
-
K
M
I
A
-
Q
---
I
K
R
E
I
S
T
M
K
L
-
I
K
H
P
N
V
I
R
M
F
E
V
M
A
S
----
K
T
K
I
Y
F
V
L
E
F
V
T
G
G
E
L
F
D
K
I
S
S
N
G
R
-
L
K
E
D
E
A
R
K
Y
F
Q
Q
L
I
N
A
V
D
Y
C
H
S
R
G
V
Y
H
R
D
L
K
P
E
N
L
L
L
D
A
---
N
G
A
L
K
V
S
D
F
G
L
S
A
L
P
QQV
R
E
D
G
L
L
H
D
T
C
G
T
P
N
Y
V
A
P
E
V
I
N
N
K
G
Y
D
G
A
--
K
---
A
D
L
W
S
C
G
V
I
L
F
V
L
M
A
G
Y
L
P
F
E
D
-
S
N
L
----
T
S
L
Y
K
K
I
F
K
A
E
F
T
C
-
P
----
P
----
W
---
F
S
A
S
A
K
K
L
I
K
R
I
L
D
P
N
P
A
T
R
I
T
F
A
E
V
I
E
N
E
W
-
F
-
K
K
G
Y
-
K
A
P
K
F
E
---
D
D
-
V
D
A
I
F
D
D
S
G
--------------------------------------------------------------------------------------------
45
PsiBlast_CBE
66.76
36%
-110
- C1 -
4CZU
3
CIPKN_ARATH
C:
[9-269]
---------------------------------------------------------------------
R
V
G
K
Y
E
L
G
R
-
T
--
L
G
E
G
T
F
A
K
V
K
F
A
R
N
V
E
N
G
D
N
V
A
I
K
V
I
D
K
E
K
V
L
K
N
-
K
M
I
A
-
Q
---
I
K
R
E
I
S
T
M
K
L
-
I
K
H
P
N
V
I
R
M
F
E
V
M
A
S
----
K
T
K
I
Y
F
V
L
E
F
V
T
G
G
E
L
F
D
K
I
S
S
N
G
R
-
L
K
E
D
E
A
R
K
Y
F
Q
Q
L
I
N
A
V
D
Y
C
H
S
R
G
V
Y
H
R
D
L
K
P
E
N
L
L
L
D
A
---
N
G
A
L
K
V
S
D
F
G
L
S
A
L
P
QQV
R
E
D
G
L
L
H
D
T
C
G
T
P
N
Y
V
A
P
E
V
I
N
N
K
G
Y
D
G
A
--
K
---
A
D
L
W
S
C
G
V
I
L
F
V
L
M
A
G
Y
L
P
F
E
D
-
S
N
L
----
T
S
L
Y
K
K
I
F
K
A
E
F
T
C
-
P
----
P
----
W
---
F
S
A
S
A
K
K
L
I
K
R
I
L
D
P
N
P
A
T
R
I
T
F
A
E
V
I
E
N
E
W
-
F
-
K
K
G
Y
-
K
A
P
K
F
E
---
N
A
-
D
V
D
A
I
F
D
D
S
--------------------------------------------------------------------------------------------
47
PsiBlast_CBE
66.60
36%
-106
- C1 -
4CZU
3
CIPKN_ARATH
A:
[9-269]
---------------------------------------------------------------------
R
V
G
K
Y
E
L
G
R
-
T
--
L
G
E
G
T
F
A
K
V
K
F
A
R
N
V
E
N
G
D
N
V
A
I
K
V
I
D
K
E
K
V
L
K
N
-
K
M
I
A
-
Q
---
I
K
R
E
I
S
T
M
K
L
-
I
K
H
P
N
V
I
R
M
F
E
V
M
A
S
----
K
T
K
I
Y
F
V
L
E
F
V
T
G
G
E
L
F
D
K
I
S
S
N
G
R
-
L
K
E
D
E
A
R
K
Y
F
Q
Q
L
I
N
A
V
D
Y
C
H
S
R
G
V
Y
H
R
D
L
K
P
E
N
L
L
L
D
A
---
N
G
A
L
K
V
S
D
F
G
L
S
A
L
P
QQV
R
E
D
G
L
L
H
D
T
C
G
T
P
N
Y
V
A
P
E
V
I
N
N
K
G
Y
D
G
A
--
K
---
A
D
L
W
S
C
G
V
I
L
F
V
L
M
A
G
Y
L
P
F
E
D
-
S
N
L
----
T
S
L
Y
K
K
I
F
K
A
E
F
T
C
-
P
----
P
----
W
---
F
S
A
S
A
K
K
L
I
K
R
I
L
D
P
N
P
A
T
R
I
T
F
A
E
V
I
E
N
E
W
-
F
-
K
K
G
Y
-
K
A
P
K
F
E
---
N
D
-
D
V
D
A
I
F
D
D
S
-
G
E
S
K
N
L
V
V
-----------------------------------------------------------------------------------
109
PsiBlast_CBE
66.42
35%
-120
- C1 -
4BDF
3
CHK2_HUMAN
A:
[18-285]
-------------------------------------------------------------------------
Y
I
M
S
K
-
T
--
L
G
----
G
E
V
K
L
A
F
E
R
K
T
C
K
K
V
A
I
K
I
I
S
K
-------------N--
V
E
T
E
I
E
I
L
K
K
-
L
N
H
P
C
I
I
K
I
K
N
F
F
D
A
-----
E
D
Y
Y
I
V
L
E
L
M
E
G
G
E
L
F
D
K
V
V
G
N
K
R
-
L
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
E
N
G
I
I
H
R
D
L
K
P
E
N
V
L
L
S
S
QEE
D
C
L
I
K
I
T
D
F
G
H
S
K
I
L
---
G
E
T
S
L
M
R
T
L
C
G
T
P
T
Y
L
A
P
E
V
L
V
S
V
G
T
A
G
Y
NR
A
---
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
S
E
H
R
T
Q
----
V
S
L
K
D
Q
I
T
S
G
K
Y
N
F
-
I
----
P
EVWA
E
---
V
S
E
K
A
L
D
L
V
K
K
L
L
V
V
D
P
K
A
R
F
T
T
E
E
A
L
R
H
P
W
-
L
-
Q
D
E
D
-
M
K
R
K
F
Q
---
D
L
-
L
S
E
E
N
E
S
T
A
-
L
P
Q
V
L
--------------------------------------------------------------------------------------
101
PsiBlast_CBE
66.23
35%
-114
- C1 -
2YCQ
1
CHK2_HUMAN
A:
[12-279]
-------------------------------------------------------------------------
Y
I
M
S
K
-
T
--
L
G
S
G
A
C
G
E
V
K
L
A
F
E
R
K
T
C
K
K
V
A
I
K
I
I
S
K
-------------N--
V
E
T
E
I
E
I
L
K
K
-
L
N
H
P
C
I
I
K
I
K
N
F
F
D
A
-----
E
D
Y
Y
I
V
L
E
L
M
E
G
G
E
L
F
D
K
V
V
G
N
K
R
-
L
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
E
N
G
I
I
H
R
D
L
K
P
E
N
V
L
L
S
S
QEE
D
C
L
I
K
I
T
D
F
G
H
S
K
I
L
---
G
E
T
S
L
M
R
T
L
C
G
T
P
T
Y
L
A
P
E
V
L
V
S
V
G
T
A
G
Y
NR
A
---
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
S
E
H
R
T
Q
----
V
S
L
K
D
Q
I
T
S
G
K
Y
N
F
-
I
----
P
EVWA
E
---
V
S
E
K
A
L
D
L
V
K
K
L
L
V
V
D
P
K
A
R
F
T
T
E
E
A
L
R
H
P
W
-
L
-
Q
D
E
D
-
M
K
R
K
F
Q
---
D
L
-
L
S
E
E
N
E
S
T
A
-
L
P
Q
----------------------------------------------------------------------------------------
98
PsiBlast_CBE
65.95
35%
-120
- C1 -
2YIR
1
CHK2_HUMAN
A:
[12-279]
-------------------------------------------------------------------------
Y
I
M
S
K
-
T
--
L
G
S
G
A
C
G
E
V
K
L
A
F
E
R
K
T
C
K
K
V
A
I
K
I
I
S
K
-------------LN-
V
E
T
E
I
E
I
L
K
K
-
L
N
H
P
C
I
I
K
I
K
N
F
F
D
A
-----
E
D
Y
Y
I
V
L
E
L
M
E
G
G
E
L
F
D
K
V
V
G
N
K
R
-
L
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
E
N
G
I
I
H
R
D
L
K
P
E
N
V
L
L
S
S
QEE
D
C
L
I
K
I
T
D
F
G
H
S
K
I
L
---
G
E
T
S
L
M
R
T
L
C
G
T
P
T
Y
L
A
P
E
V
L
V
S
V
G
T
A
G
Y
NR
A
---
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
S
E
H
R
T
Q
----
V
S
L
K
D
Q
I
T
S
G
K
Y
N
F
-
I
----
P
EVWA
E
---
V
S
E
K
A
L
D
L
V
K
K
L
L
V
V
D
P
K
A
R
F
T
T
E
E
A
L
R
H
P
W
-
L
-
Q
D
E
D
-
M
K
R
K
F
Q
---
D
L
-
L
S
E
E
N
E
S
T
A
-
L
P
-----------------------------------------------------------------------------------------
95
PsiBlast_CBE
65.89
33%
-109
- C1 -
3MA6
1
?
A:
[33-292]
--------------------------------------------------------------------------
R
Y
K
G
-
Q
R
V
L
G
K
G
S
F
G
E
V
I
L
C
K
D
K
I
T
G
Q
E
C
A
V
K
V
I
S
K
R
Q
-
V
K
Q
-
K
T
D
K
E
S
---
L
L
R
E
V
Q
L
L
K
Q
-
L
D
H
P
N
I
M
K
L
Y
E
F
F
E
D
----
K
G
Y
F
Y
L
V
G
E
V
Y
T
G
G
E
L
F
D
E
I
I
S
R
K
R
-
F
S
E
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
K
N
K
I
V
H
R
D
L
K
P
E
N
L
L
L
E
S
KSK
D
A
N
I
R
I
I
D
F
G
L
S
T
H
F
---
E
-
S
K
K
M
K
D
K
I
G
T
A
Y
Y
I
A
P
E
V
L
H
-----
G
T
--
Y
DEK
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
F
N
G
-
A
N
E
----
Y
D
I
L
K
K
V
E
K
G
K
Y
T
F
-
E
L
P
Q
W
K
----
K
---
V
S
E
S
A
K
D
L
I
R
K
M
L
T
Y
V
P
S
M
R
I
S
A
R
D
A
L
D
H
E
W
-
I
-
Q
T
Y
T
-
K
----------------------------------------------------------------------------------------------------------------
103
PsiBlast_CBE
65.41
35%
-111
- C1 -
2YCF
1
CHK2_HUMAN
A:
[12-279]
-------------------------------------------------------------------------
Y
I
M
S
K
-
T
--
L
G
S
G
A
C
G
E
V
K
L
A
F
E
R
K
T
C
K
K
V
A
I
K
I
I
S
K
-------------N--
V
E
T
E
I
E
I
L
K
K
-
L
N
H
P
C
I
I
K
I
K
N
F
F
D
A
-----
E
D
Y
Y
I
V
L
E
L
M
E
G
G
E
L
F
D
K
V
V
G
N
K
R
-
L
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
E
N
G
I
I
H
R
D
L
K
P
E
N
V
L
L
S
S
QEE
D
C
L
I
K
I
T
D
F
G
H
S
K
I
L
---
G
E
T
S
L
M
R
T
L
C
G
T
P
T
Y
L
A
P
E
V
L
V
S
V
G
T
A
G
Y
NR
A
---
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
S
E
H
R
T
Q
----
V
S
L
K
D
Q
I
T
S
G
K
Y
N
F
-
I
----
P
EVWA
E
---
V
S
E
K
A
L
D
L
V
K
K
L
L
V
V
D
P
K
A
R
F
T
T
E
E
A
L
R
H
P
W
-
L
-
Q
D
E
D
-
M
K
R
K
F
Q
---
D
L
-
L
S
E
E
N
E
S
T
A
-
L
P
Q
----------------------------------------------------------------------------------------
44
PsiBlast_CBE
65.35
36%
-105
- C1 -
4CZU
3
CIPKN_ARATH
D:
[9-269]
---------------------------------------------------------------------
R
V
G
K
Y
E
L
G
R
-
T
--
L
G
E
G
T
F
A
K
V
K
F
A
R
N
V
E
N
G
D
N
V
A
I
K
V
I
D
K
E
K
V
L
K
N
-
K
M
I
A
-
Q
---
I
K
R
E
I
S
T
M
K
L
-
I
K
H
P
N
V
I
R
M
F
E
V
M
A
S
----
K
T
K
I
Y
F
V
L
E
F
V
T
G
G
E
L
F
D
K
I
S
S
N
G
R
-
L
K
E
D
E
A
R
K
Y
F
Q
Q
L
I
N
A
V
D
Y
C
H
S
R
G
V
Y
H
R
D
L
K
P
E
N
L
L
L
D
A
---
N
G
A
L
K
V
S
D
F
G
L
S
A
L
P
QQV
R
E
D
G
L
L
H
D
T
C
G
T
P
N
Y
V
A
P
E
V
I
N
N
K
G
Y
D
G
A
--
K
---
A
D
L
W
S
C
G
V
I
L
F
V
L
M
A
G
Y
L
P
F
E
D
-
S
N
L
----
T
S
L
Y
K
K
I
F
K
A
E
F
T
C
-
P
----
P
----
W
---
F
S
A
S
A
K
K
L
I
K
R
I
L
D
P
N
P
A
T
R
I
T
F
A
E
V
I
E
N
E
W
-
F
-
K
K
G
Y
-
K
A
P
K
F
E
---
N
A
-
D
V
S
L
D
D
V
D
A
-
I
F
D
D
S
N
L
V
V
E
R
R
E
------------------------------------------------------------------------------
104
PsiBlast_CBE
65.30
35%
-120
- C1 -
4BDK
4
CHK2_HUMAN
A:
[18-285]
-------------------------------------------------------------------------
Y
I
M
S
K
-
T
--
L
G
----
G
E
V
K
L
A
F
E
R
K
T
C
K
K
V
A
I
K
I
I
S
K
-------------A
L
N
V
E
T
E
I
E
I
L
K
K
-
L
N
H
P
C
I
I
K
I
K
N
F
F
D
A
-----
E
D
Y
Y
I
V
L
E
L
M
E
G
G
E
L
F
D
K
V
V
G
N
K
R
-
L
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
E
N
G
I
I
H
R
D
L
K
P
E
N
V
L
L
S
S
QEE
D
C
L
I
K
I
T
D
F
G
H
S
K
I
L
---
G
E
T
S
L
M
R
T
L
C
G
T
P
T
Y
L
A
P
E
V
L
V
S
V
G
T
A
G
Y
NR
A
---
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
S
E
H
R
T
Q
----
V
S
L
K
D
Q
I
T
S
G
K
Y
N
F
-
I
----
P
EVWA
E
---
V
S
E
K
A
L
D
L
V
K
K
L
L
V
V
D
P
K
A
R
F
T
T
E
E
A
L
R
H
P
W
-
L
-
Q
D
E
D
-
M
K
R
K
F
Q
---
D
L
-
L
S
E
E
N
E
S
T
A
-
L
P
Q
V
L
A
-------------------------------------------------------------------------------------
111
PsiBlast_CBE
65.25
35%
-126
- C1 -
4BDD
3
CHK2_HUMAN
A:
[18-285]
-------------------------------------------------------------------------
Y
I
M
S
K
-
T
--
L
------
E
V
K
L
A
F
E
R
K
T
C
K
K
V
A
I
K
I
I
S
K
-------------N--
V
E
T
E
I
E
I
L
K
K
-
L
N
H
P
C
I
I
K
I
K
N
F
F
D
A
-----
E
D
Y
Y
I
V
L
E
L
M
E
G
G
E
L
F
D
K
V
V
G
N
K
R
-
L
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
E
N
G
I
I
H
R
D
L
K
P
E
N
V
L
L
S
S
QEE
D
C
L
I
K
I
T
D
F
G
H
S
K
I
L
-----
T
S
L
M
R
T
L
C
G
T
P
T
Y
L
A
P
E
V
L
V
S
V
G
T
A
G
Y
NR
A
---
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
S
E
H
R
T
Q
----
V
S
L
K
D
Q
I
T
S
G
K
Y
N
F
-
I
----
P
EVWA
E
---
V
S
E
K
A
L
D
L
V
K
K
L
L
V
V
D
P
K
A
R
F
T
T
E
E
A
L
R
H
P
W
-
L
-
Q
D
E
D
-
M
K
R
K
F
Q
---
D
L
-
L
S
E
E
N
E
S
T
A
-
L
P
Q
V
L
--------------------------------------------------------------------------------------
99
PsiBlast_CBE
65.03
35%
-116
- C1 -
2YIQ
1
CHK2_HUMAN
A:
[12-279]
-------------------------------------------------------------------------
Y
I
M
S
K
-
T
--
L
G
----
G
E
V
K
L
A
F
E
R
K
T
C
K
K
V
A
I
K
I
I
S
K
----------------
V
E
T
E
I
E
I
L
K
K
-
L
N
H
P
C
I
I
K
I
K
N
F
F
D
A
-----
E
D
Y
Y
I
V
L
E
L
M
E
G
G
E
L
F
D
K
V
V
G
N
K
R
-
L
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
E
N
G
I
I
H
R
D
L
K
P
E
N
V
L
L
S
S
QEE
D
C
L
I
K
I
T
D
F
G
H
S
K
I
L
---
G
E
T
S
L
M
R
T
L
C
G
T
P
T
Y
L
A
P
E
V
L
V
S
V
G
T
A
G
Y
NR
A
---
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
S
E
H
R
T
Q
----
V
S
L
K
D
Q
I
T
S
G
K
Y
N
F
-
I
----
P
EVWA
E
---
V
S
E
K
A
L
D
L
V
K
K
L
L
V
V
D
P
K
A
R
F
T
T
E
E
A
L
R
H
P
W
-
L
-
Q
D
E
D
-
M
K
R
K
F
Q
---
D
L
-
L
S
E
E
N
E
S
T
A
-
L
P
Q
----------------------------------------------------------------------------------------
112
PsiBlast_CBE
64.87
35%
-124
- C1 -
4BDC
2
CHK2_HUMAN
A:
[18-285]
-------------------------------------------------------------------------
Y
I
M
S
K
-
T
--
L
G
S
----
E
V
K
L
A
F
E
R
K
T
C
K
K
V
A
I
K
I
I
S
K
-------------N--
V
E
T
E
I
E
I
L
K
K
-
L
N
H
P
C
I
I
K
I
K
N
F
F
D
A
-----
E
D
Y
Y
I
V
L
E
L
M
E
G
G
E
L
F
D
K
V
V
G
N
K
R
-
L
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
E
N
G
I
I
H
R
D
L
K
P
E
N
V
L
L
S
S
QEE
D
C
L
I
K
I
T
D
F
G
H
S
K
I
L
----
E
T
S
L
M
R
T
L
C
G
T
P
T
Y
L
A
P
E
V
L
V
S
V
G
T
A
G
Y
NR
A
---
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
S
E
H
R
T
Q
----
V
S
L
K
D
Q
I
T
S
G
K
Y
N
F
-
I
----
P
EVWA
E
---
V
S
E
K
A
L
D
L
V
K
K
L
L
V
V
D
P
K
A
R
F
T
T
E
E
A
L
R
H
P
W
-
L
-
Q
D
E
D
-
M
K
R
K
F
Q
---
D
L
-
L
S
E
E
N
E
S
T
A
-
L
P
Q
V
L
--------------------------------------------------------------------------------------
108
PsiBlast_CBE
64.81
35%
-117
- C1 -
4BDG
2
CHK2_HUMAN
A:
[18-285]
-------------------------------------------------------------------------
Y
I
M
S
K
-
T
--
L
G
S
---
G
E
V
K
L
A
F
E
R
K
T
C
K
K
V
A
I
K
I
I
S
K
-------------N--
V
E
T
E
I
E
I
L
K
K
-
L
N
H
P
C
I
I
K
I
K
N
F
F
D
A
-----
E
D
Y
Y
I
V
L
E
L
M
E
G
G
E
L
F
D
K
V
V
G
N
K
R
-
L
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
E
N
G
I
I
H
R
D
L
K
P
E
N
V
L
L
S
S
QEE
D
C
L
I
K
I
T
D
F
G
H
S
K
I
L
---
G
E
T
S
L
M
R
T
L
C
G
T
P
T
Y
L
A
P
E
V
L
V
S
V
G
T
A
G
Y
NR
A
---
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
S
E
H
R
T
Q
----
V
S
L
K
D
Q
I
T
S
G
K
Y
N
F
-
I
----
P
EVWA
E
---
V
S
E
K
A
L
D
L
V
K
K
L
L
V
V
D
P
K
A
R
F
T
T
E
E
A
L
R
H
P
W
-
L
-
Q
D
E
D
-
M
K
R
K
F
Q
---
D
L
-
L
S
E
E
N
E
S
T
A
-
L
P
Q
V
L
--------------------------------------------------------------------------------------
110
PsiBlast_CBE
64.54
35%
-124
- C1 -
4BDE
5
CHK2_HUMAN
A:
[18-285]
-------------------------------------------------------------------------
Y
I
M
S
K
-
T
--
L
------
E
V
K
L
A
F
E
R
K
T
C
K
K
V
A
I
K
I
I
S
K
-------------A
L
N
V
E
T
E
I
E
I
L
K
K
-
L
N
H
P
C
I
I
K
I
K
N
F
F
D
A
-----
E
D
Y
Y
I
V
L
E
L
M
E
G
G
E
L
F
D
K
V
V
G
N
K
R
-
L
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
E
N
G
I
I
H
R
D
L
K
P
E
N
V
L
L
S
S
QEE
D
C
L
I
K
I
T
D
F
G
H
S
K
I
L
-----
T
S
L
M
R
T
L
C
G
T
P
T
Y
L
A
P
E
V
L
V
S
V
G
T
A
G
Y
NR
A
---
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
S
E
H
R
T
Q
----
V
S
L
K
D
Q
I
T
S
G
K
Y
N
F
-
I
----
P
EVWA
E
---
V
S
E
K
A
L
D
L
V
K
K
L
L
V
V
D
P
K
A
R
F
T
T
E
E
A
L
R
H
P
W
-
L
-
Q
D
E
D
-
M
K
R
K
F
Q
---
D
L
-
L
S
E
E
N
E
S
T
A
-
L
P
Q
V
L
A
-------------------------------------------------------------------------------------
94
PsiBlast_CBE
63.95
33%
-108
- C1 -
3MA6
1
?
B:
[33-292]
--------------------------------------------------------------------------
R
Y
K
G
-
Q
RV
L
G
K
G
S
F
G
E
V
I
L
C
K
D
K
I
T
G
Q
E
C
A
V
K
V
I
S
K
R
Q
-
V
K
Q
--
T
D
K
E
S
---
L
L
R
E
V
Q
L
L
K
Q
-
L
D
H
P
N
I
M
K
L
Y
E
F
F
E
D
----
K
G
Y
F
Y
L
V
G
E
V
Y
T
G
G
E
L
F
D
E
I
I
S
R
K
R
-
F
S
E
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
K
N
K
I
V
H
R
D
L
K
P
E
N
L
L
L
E
S
KSK
D
A
N
I
R
I
I
D
F
G
L
S
T
H
F
---
E
A
S
K
K
M
K
D
K
I
G
T
A
Y
Y
I
A
P
E
V
L
H
-----
G
T
--
Y
DE
K
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
F
N
G
-
A
N
E
----
Y
D
I
L
K
K
V
E
K
G
K
Y
T
F
-
E
LPQW
K
----
K
---
V
S
E
S
A
K
D
L
I
R
K
M
L
T
Y
V
P
S
M
R
I
S
A
R
D
A
L
D
H
E
W
-
I
-
Q
T
Y
T
------------------------------------------------------------------------------------------------------------------
105
PsiBlast_CBE
63.48
35%
-122
- C1 -
4BDJ
1
CHK2_HUMAN
A:
[18-285]
-------------------------------------------------------------------------
Y
I
M
S
K
-
T
--
L
G
-----
E
V
K
L
A
F
E
R
K
T
C
K
K
V
A
I
K
I
I
S
K
-------------N--
V
E
T
E
I
E
I
L
K
K
-
L
N
H
P
C
I
I
K
I
K
N
F
F
D
A
-----
E
D
Y
Y
I
V
L
E
L
M
E
G
G
E
L
F
D
K
V
V
G
N
K
R
-
L
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
E
N
G
I
I
H
R
D
L
K
P
E
N
V
L
L
S
S
QEE
D
C
L
I
K
I
T
D
F
G
H
S
K
I
L
----
E
T
S
L
M
R
T
L
C
G
T
P
T
Y
L
A
P
E
V
L
V
S
V
G
T
A
G
Y
NR
A
---
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
S
E
H
R
T
Q
----
V
S
L
K
D
Q
I
T
S
G
K
Y
N
F
-
I
----
P
EVWA
E
---
V
S
E
K
A
L
D
L
V
K
K
L
L
V
V
D
P
K
A
R
F
T
T
E
E
A
L
R
H
P
W
-
L
-
Q
D
E
D
-
M
K
R
K
F
Q
---
D
L
-
L
S
E
E
N
E
S
T
A
-
L
P
Q
V
L
A
-------------------------------------------------------------------------------------
41
PsiBlast_CBE
63.39
36%
-113
- C1 -
4CZT
3
CIPKN_ARATH
C:
[10-269]
----------------------------------------------------------------------
V
G
K
Y
E
L
G
R
-
T
--
L
G
E
G
T
F
A
K
V
K
F
A
R
N
V
E
N
G
D
N
V
A
I
K
V
I
D
K
E
K
V
L
K
N
-
K
M
I
A
-
Q
---
I
K
R
E
I
S
T
M
K
L
-
I
K
H
P
N
V
I
R
M
F
E
V
M
A
S
----
K
T
K
I
Y
F
V
L
E
F
V
T
G
G
E
L
F
D
K
I
S
S
N
G
R
-
L
K
E
D
E
A
R
K
Y
F
Q
Q
L
I
N
A
V
D
Y
C
H
S
R
G
V
Y
H
R
D
L
K
P
E
N
L
L
L
D
A
---
N
G
A
L
K
V
S
D
F
G
L
S
A
L
P
QQV
R
E
D
G
L
L
H
T
T
C
G
T
P
N
Y
V
A
P
E
V
I
N
N
K
G
Y
D
G
A
--
K
---
A
D
L
W
S
C
G
V
I
L
F
V
L
M
A
G
Y
L
P
F
E
D
-
S
N
L
----
T
S
L
Y
K
K
I
F
K
A
E
F
T
C
-
P
----
P
----
W
---
F
S
A
S
A
K
K
L
I
K
R
I
L
D
P
N
P
A
T
R
I
T
F
A
E
V
I
E
N
E
W
-
F
-
K
K
G
Y
-
K
A
P
K
F
E
---
N
A
-
D
V
S
L
D
D
V
D
A
-
I
F
D
D
S
G
-------------------------------------------------------------------------------------
56
PsiBlast_CBE
63.24
36%
-105
- C1 -
2JAM
3
KCC1G_HUMAN
B:
[17-267]
----------------------------------------------------------------------------------
L
G
S
G
A
F
S
E
V
F
L
V
K
Q
R
L
T
G
K
L
F
A
L
K
C
I
K
K
S
--------
S
------
L
E
N
E
I
A
V
L
K
K
-
I
K
H
E
N
I
V
T
L
E
D
I
Y
E
S
----
T
T
H
Y
Y
L
V
M
Q
L
V
S
G
G
E
L
F
D
R
I
L
E
R
G
V
-
Y
T
E
K
D
A
S
L
V
I
Q
Q
V
L
S
A
V
K
Y
L
H
E
N
G
I
V
H
R
D
L
K
P
E
N
L
L
Y
L
T
PEE
N
S
K
I
M
I
T
D
F
G
L
S
K
M
E
---
Q
N
G
-
I
M
S
T
A
C
G
T
P
G
Y
V
A
P
E
V
L
A
Q
K
P
Y
S
K
A
------
V
D
C
W
S
I
G
V
I
T
Y
I
L
L
C
G
Y
P
P
F
Y
E
-
E
T
E
----
S
K
L
F
E
K
I
K
E
G
Y
Y
E
F
-
E
----
S
PFWD
D
---
I
S
E
S
A
K
D
F
I
C
H
L
L
E
K
D
P
N
E
R
Y
T
C
E
K
A
L
S
H
P
W
-
I
-
D
G
N
T
-
A
L
H
R
D
I
---
Y
P
-
S
V
S
L
Q
I
Q
K
N
-
F
A
K
----------------------------------------------------------------------------------------
135
HHSearch
62.34
33%
-95
- C1 -
1NXK
1
MAPK2_HUMAN
A:
[55-345]
-----------------------------------------------------------------
K
K
N
A
I
I
D
D
Y
K
V
T
S
Q
V
--
L
G
L
G
I
N
G
K
V
L
Q
I
F
N
K
R
T
Q
E
K
F
A
L
K
M
L
Q
D
C
P
----------
K
---
A
R
R
E
V
E
L
H
W
R
A
S
Q
C
P
H
I
V
R
I
V
D
V
Y
E
N
LYAG
R
K
C
L
L
I
V
M
E
C
L
D
G
G
E
L
F
S
R
I
Q
D
R
--A
F
T
E
R
E
A
S
E
I
M
K
S
I
G
E
A
I
Q
Y
L
H
S
I
N
I
A
H
R
D
V
K
P
E
N
L
L
Y
T
S
KRP
N
A
I
L
K
L
T
D
F
G
F
A
K
E
T
---
T
-----------
P
Y
Y
V
A
P
E
V
L
G
P
E
K
Y
-
D
K
--
S
---
C
D
M
W
S
L
G
V
I
M
Y
I
L
L
C
G
Y
P
P
F
Y
S
-
N
H
G
LAIS
P
G
M
K
T
R
I
R
M
G
Q
Y
E
F
-
P
----
N
PEWS
E
---
V
S
E
E
V
K
M
L
I
R
N
L
L
K
T
E
P
T
Q
R
M
T
I
T
E
F
M
N
H
P
W
-
I
-
M
Q
S
T
-
K
-
V
P
Q
T
---
P
L
-
H
T
-
S
R
V
L
K
E
D-------------------------------------------------------------------------------------------
57
PsiBlast_CBE
61.38
36%
-108
- C1 -
2JAM
3
KCC1G_HUMAN
A:
[17-267]
----------------------------------------------------------------------------------
L
G
S
G
A
F
S
E
V
F
L
V
K
Q
R
L
T
G
K
L
F
A
L
K
C
I
K
K
S
--------
S
------
L
E
N
E
I
A
V
L
K
K
-
I
K
H
E
N
I
V
T
L
E
D
I
Y
E
S
----
T
T
H
Y
Y
L
V
M
Q
L
V
S
G
G
E
L
F
D
R
I
L
E
R
G
V
-
Y
T
E
K
D
A
S
L
V
I
Q
Q
V
L
S
A
V
K
Y
L
H
E
N
G
I
V
H
R
D
L
K
P
E
N
L
L
Y
L
T
PEE
N
S
K
I
M
I
T
D
F
G
L
S
K
M
E
---
Q
N
G
-
I
M
S
T
A
C
G
T
P
G
Y
V
A
P
E
V
L
A
Q
K
P
Y
S
K
A
------
V
D
C
W
S
I
G
V
I
T
Y
I
L
L
C
G
Y
P
P
F
Y
E
-
E
T
E
----
S
K
L
F
E
K
I
K
E
G
Y
Y
E
F
-
E
----
S
PFWD
D
---
I
S
E
S
A
K
D
F
I
C
H
L
L
E
K
D
P
N
E
R
Y
T
C
E
K
A
L
S
H
P
W
-
I
-
D
G
N
T
-
A
L
H
R
D
I
---
Y
P
-
S
V
S
L
Q
I
Q
K
N
-
F
A
K
S
---------------------------------------------------------------------------------------