@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : RK_HUMAN: (2015-10-18 )
MDFGSLETVVANSAFIAARGSFDGSSSQPSRDKKYLAKLKLPPLSKCESLRDSLSLEFESVCLEQPIGKKLFQQFLQSAEKHLPALELWKDIEDYDTADNDLQPQKAQTILAQYLDPQAKLFCSFLDEGIVAKFKEGPVEIQDGLFQPLLQATLAHLGQAPFQEYLGSLYFLRFLQWKWLEAQPMGEDWFLDFRVLGKGGFGEVSACQMKATGKLYACKKLNKKRLKKRKGYQGAMVEKKILMKVHSRFIVSLAYAFETKADLCLVMTIMNGGDIRYHIYNVNEENPGFPEPRALFYTAQIICGLEHLHQRRIVYRDLKPENVLLDNDGNVRISDLGLAVELLDGQSKTKGYAGTPGFMAPELLQGEEYDFSVDYFALGVTLYEMIAARGPFRARGEKVENKELKHRIISEPVKYPDKFSQASKDFCEALLEKDPEKRLGFRDETCDKLRAHPLFKDLNWRQLEAGMLMPPFIPDSKTVYAKDIQDVGAFSTVKGVAFDKTDTEFFQEFATGNCPIPWQEEMIETGIFGELNVWRSDGQMPDDMKGISGGSSSSSKSGMCLVS
Atome Classification :
(61 SA)
.........10........20........30........40......--..50........60........70....-....80........----90........100..-..-...110.......120.......130----.......---140-..--.....150.......160.......170.......180.-......190.......200.......---210.......220......-.230.......240-..-.-..---.---.250.......260.......270.......280.......290.......300.......-310........320.......330.......340.......350.......360...-....370.......380.......390.......400.......410.......420.......430.......440-.-......450.......460.......470.......480.......490--.--.......500.......510.......520.......530.......540.......550.......560.
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MDFG
S
L
E
T
V
VAN
S
A
F
I
A
A
RGSFDGSSSQP
S
R
D
K
K
Y
L
A
KLKLP
P
L
S
K
C
--
E
S
L
R
D
S
L
S
L
E
F
E
S
V
C
LEQ
P
I
G
K
K
L
F
Q
Q
F
-
L
Q
S
A
E
K
HL
P
A
L
E
L
W
----
K
D
I
E
DYDTADNDLQ
P
-
Q
K
-
A
Q
T
I
L
A
Q
YL
D
P
Q
A
K
L
F
C
S
F
L
DE
G
I
V
A
----
K
FKEGPV---
E
I
Q
-
D
G
--
L
F
Q
P
L
L
Q
A
T
L
A
HLG
Q
A
P
F
Q
E
Y
L
G
S
L
Y
F
L
R
F
L
Q
W
K
WLEAQ-PMGED
W
F
L
D
F
R
V
L
GKGGFGEV
S
A
C
Q
M
---KATGK
L
Y
A
C
K
KL
N
K
K
R
L
K
K
-RKGYQ
G
A
M
V
E
K
K
I
L
-
M
K
-
V
-
H
S
---
R
---
F
I
V
S
L
A
Y
A
FETKA
D
L
C
L
V
M
T
IMNGG
D
I
R
Y
H
I
Y
NVNEENPGFPEPR
A
L
F
Y
T
A
Q
I
I
C
G
L
E
H
L
H
-
Q
-
R
R
I
V
Y
RDLKPE
N
V
L
LDNDG
N
V
R
I
SDL
G
L
A
V
E
LLDGQSKTKGYAGTPGFM
A
P
E
LLQ-GEEYDF
S
V
D
Y
F
A
L
G
V
T
L
Y
E
M
I
AARGPFRARGEKVE
N
K
E
L
K
H
R
I
ISEPVKY
P
D
K
F
S
Q
A
S
K
D
F
C
E
A
L
L
EKD
P
E
K
RLGFR-D-E
T
C
D
K
L
RAHPLFKDL
N
W
R
Q
LEAGMLMPPFIPDSKT
V
Y
A
K
D
I
Q
D
VGAFS---T--VKGVAFDKT
D
T
E
F
F
Q
E
FATGNCPIP
W
Q
E
E
M
I
ETGIFGE
L
N
V
WRSDGQMPDDMKGISGGSSSSSKS
G
M
C
LVS
7
PsiBlast_PDB
99.28
83%
-108
- C1 -
4L9I
2
RK_BOVIN
A:
[1-503]
-----------------------------
S
R
D
R
K
Y
L
A
R
L
K
L
P
P
L
S
K
C
--
E
A
L
R
E
S
L
D
L
G
F
E
G
M
C
L
E
Q
P
I
G
K
R
L
F
Q
Q
F
-
L
R
T
H
E
Q
H
G
P
A
L
Q
L
W
----
K
D
I
E
D
Y
D
T
A
D
D
A
L
R
P
-
Q
K
-
A
Q
A
L
R
A
A
Y
L
E
P
Q
A
Q
L
F
C
S
F
L
D
A
E
T
V
A
----
R
A
R
A
G
------
A
G
-
D
G
--
L
F
Q
P
L
L
R
A
V
L
A
H
L
G
Q
A
P
F
Q
E
F
L
D
S
L
Y
F
L
R
F
L
Q
W
K
W
L
E
A
Q
-
P
M
G
E
D
W
F
L
D
F
R
V
L
G
R
G
G
F
G
E
V
F
A
C
Q
M
---
K
A
T
G
K
L
Y
A
C
K
K
L
N
K
K
R
L
K
K
-
R
K
G
Y
Q
G
A
M
V
E
K
K
I
L
-
A
K
-
V
-
H
S
---
R
---
F
I
V
S
L
A
Y
A
F
E
T
K
T
D
L
C
L
V
M
T
I
M
N
G
G
D
I
R
Y
H
I
Y
N
V
D
E
D
N
P
G
F
Q
E
P
R
A
I
F
Y
T
A
Q
I
V
S
G
L
E
H
L
H
-
Q
-
R
N
I
I
Y
R
D
L
K
P
E
N
V
L
L
D
D
D
G
N
V
R
I
S
D
L
G
L
A
V
E
L
K
A
G
Q
T
K
T
K
G
Y
A
G
T
P
G
F
M
A
P
E
L
L
L
-
G
E
E
Y
D
F
S
V
D
Y
F
A
L
G
V
T
L
Y
E
M
I
A
A
R
G
P
F
R
A
R
G
E
K
V
E
N
K
E
L
K
Q
R
V
L
E
Q
A
V
T
Y
P
D
K
F
S
P
A
S
K
D
F
C
E
A
L
L
Q
K
D
P
E
K
R
L
G
F
R
-
D
-
G
S
C
D
G
L
R
T
H
P
L
F
R
D
I
S
W
R
Q
L
E
A
G
M
L
T
P
P
F
V
P
D
S
R
T
V
Y
A
K
N
I
Q
D
V
G
A
F
S
---
T
--
V
K
G
V
A
F
E
K
A
D
T
E
F
F
Q
E
F
A
S
G
T
C
P
I
P
W
Q
E
E
M
I
E
T
G
V
F
G
D
L
N
V
W
R
P
---------------------------
25
PsiBlast_CBE
98.11
83%
-107
- C1 -
3C4X
1
RK_BOVIN
B:
[31-533]
------------------------------
R
D
R
K
Y
L
A
R
L
K
L
P
P
L
S
K
C
--
E
A
L
R
E
S
L
D
L
G
F
E
G
M
C
L
E
Q
P
I
G
K
R
L
F
Q
Q
F
-
L
R
T
H
E
Q
H
G
P
A
L
Q
L
W
----
K
D
I
E
D
Y
D
T
A
D
D
A
L
R
P
-
Q
K
-
A
Q
A
L
R
A
A
Y
L
E
P
Q
A
Q
L
F
C
S
F
L
D
A
E
T
V
A
----
R
A
-----------------
F
Q
P
L
L
R
A
V
L
A
H
L
G
Q
A
P
F
Q
E
F
L
D
S
L
Y
F
L
R
F
L
Q
W
K
W
L
E
A
Q
-
P
M
G
E
D
W
F
L
D
F
R
V
L
G
R
G
G
F
G
E
V
F
A
C
Q
M
---
K
A
T
G
K
L
Y
A
C
K
K
L
N
K
K
R
L
K
K
-
R
K
G
Y
Q
G
A
M
V
E
K
K
I
L
-
A
K
-
V
-
H
S
---
R
---
F
I
V
S
L
A
Y
A
F
E
T
K
T
D
L
C
L
V
M
T
I
M
N
G
G
D
I
R
Y
H
I
Y
N
V
D
E
D
N
P
G
F
Q
E
P
R
A
I
F
Y
T
A
Q
I
V
S
G
L
E
H
L
H
-
Q
-
R
N
I
I
Y
R
D
L
K
P
E
N
V
L
L
D
D
D
G
N
V
R
I
S
D
L
G
L
A
V
E
L
K
A
G
Q
T
K
T
K
G
Y
A
G
T
P
G
F
M
A
P
E
L
L
L
-
G
E
E
Y
D
F
S
V
D
Y
F
A
L
G
V
T
L
Y
E
M
I
A
A
R
G
P
F
R
A
R
G
E
K
V
E
N
K
E
L
K
Q
R
V
L
E
Q
A
V
T
Y
P
D
K
F
S
P
A
S
K
D
F
C
E
A
L
L
Q
K
D
P
E
K
R
L
G
F
R
-
D
-
G
S
C
D
G
L
R
T
H
P
L
F
R
D
I
S
W
R
Q
L
E
A
G
M
L
T
P
P
F
V
P
D
S
R
T
-------------------------
E
K
A
D
T
E
F
F
Q
E
F
A
S
G
T
C
P
I
P
W
Q
E
E
M
I
E
T
G
V
F
G
D
L
N
V
W
R
P
---------------------------
5
PsiBlast_PDB
97.91
83%
-105
- C1 -
3C4W
1
RK_BOVIN
A:
[31-533]
------------------------------
R
D
R
K
Y
L
A
R
L
K
L
P
P
L
S
K
C
--
E
A
L
R
E
S
L
D
L
G
F
E
G
M
C
L
E
Q
P
I
G
K
R
L
F
Q
Q
F
-
L
R
T
H
E
Q
H
G
P
A
L
Q
L
W
----
K
D
I
E
D
Y
D
T
A
D
D
A
L
R
P
-
Q
K
-
A
Q
A
L
R
A
A
Y
L
E
P
Q
A
Q
L
F
C
S
F
L
D
A
E
T
V
A
----
R
A
R
A
G
A
------
G
-
D
G
--
L
F
Q
P
L
L
R
A
V
L
A
H
L
G
Q
A
P
F
Q
E
F
L
D
S
L
Y
F
L
R
F
L
Q
W
K
W
L
E
A
Q
-
P
M
G
E
D
W
F
L
D
F
R
V
L
G
R
G
G
F
G
E
V
F
A
C
Q
M
---
K
A
T
G
K
L
Y
A
C
K
K
L
N
K
K
R
L
K
K
-
R
K
G
Y
Q
G
A
M
V
E
K
K
I
L
-
A
K
-
V
-
H
S
---
R
---
F
I
V
S
L
A
Y
A
F
E
T
K
T
D
L
C
L
V
M
T
I
M
N
G
G
D
I
R
Y
H
I
Y
N
V
D
E
D
N
P
G
F
Q
E
P
R
A
I
F
Y
T
A
Q
I
V
S
G
L
E
H
L
H
-
Q
-
R
N
I
I
Y
R
D
L
K
P
E
N
V
L
L
D
D
D
G
N
V
R
I
S
D
L
G
L
A
V
E
L
K
A
G
Q
T
K
T
K
G
Y
A
G
T
P
G
F
M
A
P
E
L
L
L
-
G
E
E
Y
D
F
S
V
D
Y
F
A
L
G
V
T
L
Y
E
M
I
A
A
R
G
P
F
R
A
R
G
E
K
V
E
N
K
E
L
K
Q
R
V
L
E
Q
A
V
T
Y
P
D
K
F
S
P
A
S
K
D
F
C
E
A
L
L
Q
K
D
P
E
K
R
L
G
F
R
-
D
-
G
S
C
D
G
L
R
T
H
P
L
F
R
D
I
S
W
R
Q
L
E
A
G
M
L
T
P
P
F
V
P
D
---------
Q
D
V
G
A
F
S
---
T
--
V
K
G
V
A
F
E
K
A
D
T
E
F
F
Q
E
F
A
S
G
T
C
P
I
P
W
Q
E
E
M
I
E
T
G
V
F
G
D
L
N
V
W
R
P
---------------------------
24
PsiBlast_CBE
97.46
83%
-105
- C1 -
3C50
1
RK_BOVIN
B:
[30-533]
-----------------------------
S
R
D
R
K
Y
L
A
R
L
K
L
P
P
L
S
K
C
--
E
A
L
R
E
S
L
D
L
G
F
E
G
M
C
L
E
Q
P
I
G
K
R
L
F
Q
Q
F
-
L
R
T
H
E
Q
H
G
P
A
L
Q
L
W
----
K
D
I
E
D
Y
D
T
A
D
D
A
L
R
P
-
Q
K
-
A
Q
A
L
R
A
A
Y
L
E
P
Q
A
Q
L
F
C
S
F
L
D
A
E
T
V
A
----
R
A
R
A
G
A
------
G
-
D
G
--
L
F
Q
P
L
L
R
A
V
L
A
H
L
G
Q
A
P
F
Q
E
F
L
D
S
L
Y
F
L
R
F
L
Q
W
K
W
L
E
A
Q
-
P
M
G
E
D
W
F
L
D
F
R
V
L
G
R
G
G
F
G
E
V
F
A
C
Q
M
---
K
A
T
G
K
L
Y
A
C
K
K
L
N
K
K
R
L
K
K
-
R
K
G
Y
Q
G
A
M
V
E
K
K
I
L
-
A
K
-
V
-
H
S
---
R
---
F
I
V
S
L
A
Y
A
F
E
T
K
T
D
L
C
L
V
M
T
I
M
N
G
G
D
I
R
Y
H
I
Y
N
V
D
E
D
N
P
G
F
Q
E
P
R
A
I
F
Y
T
A
Q
I
V
S
G
L
E
H
L
H
-
Q
-
R
N
I
I
Y
R
D
L
K
P
E
N
V
L
L
D
D
D
G
N
V
R
I
S
D
L
G
L
A
V
E
L
K
A
G
Q
T
K
T
K
G
Y
A
G
T
P
G
F
M
A
P
E
L
L
L
-
G
E
E
Y
D
F
S
V
D
Y
F
A
L
G
V
T
L
Y
E
M
I
A
A
R
G
P
F
R
A
R
G
E
K
V
E
N
K
E
L
K
Q
R
V
L
E
Q
A
V
T
Y
P
D
K
F
S
P
A
S
K
D
F
C
E
A
L
L
Q
K
D
P
E
K
R
L
G
F
R
-
D
-
G
S
C
D
G
L
R
T
H
P
L
F
R
D
I
S
W
R
Q
L
E
A
G
M
L
T
P
P
F
V
P
D
S
R
T
V
Y
A
--------
F
S
---
T
--
V
K
G
V
A
F
E
K
A
D
T
E
F
F
Q
E
F
A
S
G
T
C
P
I
P
W
Q
E
E
M
I
E
T
G
V
F
G
D
L
N
V
W
R
P
---------------------------
88
HHSearch
97.36
84%
-107
- C1 -
3C4Z
1
RK_BOVIN
A:
[31-533]
------------------------------
R
D
R
K
Y
L
A
R
L
K
L
P
P
L
S
K
C
--
E
A
L
R
E
S
L
D
L
G
F
E
G
M
C
L
E
Q
P
I
G
K
R
L
F
Q
Q
F
-
L
R
T
H
E
Q
H
G
P
A
L
Q
L
W
----
K
D
I
E
D
Y
D
T
A
D
D
A
L
R
P
-
Q
K
-
A
Q
A
L
R
A
A
Y
L
E
P
Q
A
Q
L
F
C
S
F
L
D
A
E
T
V
A
----
R
A
R
A
------
G
----
G
--
L
F
Q
P
L
L
R
A
V
L
A
H
L
G
Q
A
P
F
Q
E
F
L
D
S
L
Y
F
L
R
F
L
Q
W
K
W
L
E
A
Q
-
P
M
G
E
D
W
F
L
D
F
R
V
L
G
R
G
G
F
G
E
V
F
A
C
Q
M
---
K
A
T
G
K
L
Y
A
C
K
K
L
N
K
K
R
L
K
K
-
R
K
G
Y
Q
G
A
M
V
E
K
K
I
L
-
A
K
-
V
-
H
S
---
R
---
F
I
V
S
L
A
Y
A
F
E
T
K
T
D
L
C
L
V
M
T
I
M
N
G
G
D
I
R
Y
H
I
Y
N
V
D
E
D
N
P
G
F
Q
E
P
R
A
I
F
Y
T
A
Q
I
V
S
G
L
E
H
L
H
-
Q
-
R
N
I
I
Y
R
D
L
K
P
E
N
V
L
L
D
D
D
G
N
V
R
I
S
D
L
G
L
A
V
E
L
K
A
G
Q
T
K
T
K
G
Y
A
G
T
P
G
F
M
A
P
E
L
L
L
-
G
E
E
Y
D
F
S
V
D
Y
F
A
L
G
V
T
L
Y
E
M
I
A
A
R
G
P
F
R
A
R
G
E
K
V
E
N
K
E
L
K
Q
R
V
L
E
Q
A
V
T
Y
P
D
K
F
S
P
A
S
K
D
F
C
E
A
L
L
Q
K
D
P
E
K
R
L
G
F
R
-
D
-
G
S
C
D
G
L
R
T
H
P
L
F
R
D
I
S
W
R
Q
L
E
A
G
M
L
T
P
P
F
V
P
D
S
R
T
V
Y
A
K
N
----
G
A
F
S
--------
G
V
A
F
E
K
A
D
T
E
F
F
Q
E
F
A
S
G
T
C
P
I
P
W
Q
E
E
M
I
E
T
G
V
F
G
D
L
N
V
W
R
P
---------------------------
3
PsiBlast_PDB
97.26
83%
-107
- C1 -
3C4Z
1
RK_BOVIN
A:
[31-533]
------------------------------
R
D
R
K
Y
L
A
R
L
K
L
P
P
L
S
K
C
--
E
A
L
R
E
S
L
D
L
G
F
E
G
M
C
L
E
Q
P
I
G
K
R
L
F
Q
Q
F
-
L
R
T
H
E
Q
H
G
P
A
L
Q
L
W
----
K
D
I
E
D
Y
D
T
A
D
D
A
L
R
P
-
Q
K
-
A
Q
A
L
R
A
A
Y
L
E
P
Q
A
Q
L
F
C
S
F
L
D
A
E
T
V
A
----
R
A
R
A
G
----------
G
--
L
F
Q
P
L
L
R
A
V
L
A
H
L
G
Q
A
P
F
Q
E
F
L
D
S
L
Y
F
L
R
F
L
Q
W
K
W
L
E
A
Q
-
P
M
G
E
D
W
F
L
D
F
R
V
L
G
R
G
G
F
G
E
V
F
A
C
Q
M
---
K
A
T
G
K
L
Y
A
C
K
K
L
N
K
K
R
L
K
K
-
R
K
G
Y
Q
G
A
M
V
E
K
K
I
L
-
A
K
-
V
-
H
S
---
R
---
F
I
V
S
L
A
Y
A
F
E
T
K
T
D
L
C
L
V
M
T
I
M
N
G
G
D
I
R
Y
H
I
Y
N
V
D
E
D
N
P
G
F
Q
E
P
R
A
I
F
Y
T
A
Q
I
V
S
G
L
E
H
L
H
-
Q
-
R
N
I
I
Y
R
D
L
K
P
E
N
V
L
L
D
D
D
G
N
V
R
I
S
D
L
G
L
A
V
E
L
K
A
G
Q
T
K
T
K
G
Y
A
G
T
P
G
F
M
A
P
E
L
L
L
-
G
E
E
Y
D
F
S
V
D
Y
F
A
L
G
V
T
L
Y
E
M
I
A
A
R
G
P
F
R
A
R
G
E
K
V
E
N
K
E
L
K
Q
R
V
L
E
Q
A
V
T
Y
P
D
K
F
S
P
A
S
K
D
F
C
E
A
L
L
Q
K
D
P
E
K
R
L
G
F
R
-
D
-
G
S
C
D
G
L
R
T
H
P
L
F
R
D
I
S
W
R
Q
L
E
A
G
M
L
T
P
P
F
V
P
D
S
R
T
V
Y
A
K
N
----
G
A
F
S
--------
G
V
A
F
E
K
A
D
T
E
F
F
Q
E
F
A
S
G
T
C
P
I
P
W
Q
E
E
M
I
E
T
G
V
F
G
D
L
N
V
W
R
P
---------------------------
79
Fugue
97.01
82%
-107
- C1 -
3C4Z
1
RK_BOVIN
A:
[31-533]
------------------------------
R
D
R
K
Y
L
A
R
L
K
L
P
P
L
S
K
C
--
E
A
L
R
E
S
L
D
L
G
F
E
G
M
C
L
E
Q
P
I
G
K
R
L
F
Q
Q
F
-
L
R
T
H
E
Q
H
G
P
A
L
Q
L
W
----
K
D
I
E
D
Y
D
T
A
D
D
A
L
R
P
-
Q
K
-
A
Q
A
L
R
A
A
Y
L
E
P
Q
A
Q
L
F
C
S
F
L
D
A
E
T
V
A
----
R
A
R
A
G
G
------------
L
F
Q
P
L
L
R
A
V
L
A
H
L
G
Q
A
P
F
Q
E
F
L
D
S
L
Y
F
L
R
F
L
Q
W
K
W
L
E
A
Q
-
P
M
G
E
D
W
F
L
D
F
R
V
L
G
R
G
G
F
G
E
V
F
A
C
Q
M
---
K
A
T
G
K
L
Y
A
C
K
K
L
N
K
K
R
L
K
K
-
R
K
G
Y
Q
G
A
M
V
E
K
K
I
L
-
A
K
-
V
-
H
S
---
R
---
F
I
V
S
L
A
Y
A
F
E
T
K
T
D
L
C
L
V
M
T
I
M
N
G
G
D
I
R
Y
H
I
Y
N
V
D
E
D
N
P
G
F
Q
E
P
R
A
I
F
Y
T
A
Q
I
V
S
G
L
E
H
L
H
-
Q
-
R
N
I
I
Y
R
D
L
K
P
E
N
V
L
L
D
D
D
G
N
V
R
I
S
D
L
G
L
A
V
E
L
K
A
G
Q
T
K
T
K
G
Y
A
G
T
P
G
F
M
A
P
E
L
L
L
-
G
E
E
Y
D
F
S
V
D
Y
F
A
L
G
V
T
L
Y
E
M
I
A
A
R
G
P
F
R
A
R
G
E
K
V
E
N
K
E
L
K
Q
R
V
L
E
Q
A
V
T
Y
P
D
K
F
S
P
A
S
K
D
F
C
E
A
L
L
Q
K
D
P
E
K
R
L
G
F
R
-
D
-
G
S
C
D
G
L
R
T
H
P
L
F
R
D
I
S
W
R
Q
L
E
A
G
M
L
T
P
P
F
V
P
D
S
R
T
V
Y
A
K
N
-------
G
---
A
--
F
S
G
V
A
F
E
K
A
D
T
E
F
F
Q
E
F
A
S
G
T
C
P
I
P
W
Q
E
E
M
I
E
T
G
V
F
G
D
L
N
V
W
R
P
---------------------------
1
PsiBlast_PDB
96.87
83%
-102
- C1 -
3C4X
1
RK_BOVIN
A:
[30-533]
-----------------------------
S
R
D
R
K
Y
L
A
R
L
K
L
P
P
L
S
K
C
--
E
A
L
R
E
S
L
D
L
G
F
E
G
M
C
L
E
Q
P
I
G
K
R
L
F
Q
Q
F
-
L
R
T
H
E
Q
H
G
P
A
L
Q
L
W
----
K
D
I
E
D
Y
D
T
A
D
D
A
L
R
P
-
Q
K
-
A
Q
A
L
R
A
A
Y
L
E
P
Q
A
Q
L
F
C
S
F
L
D
A
E
T
V
A
----
R
A
R
A
G
A
------
G
-
D
G
--
L
F
Q
P
L
L
R
A
V
L
A
H
L
G
Q
A
P
F
Q
E
F
L
D
S
L
Y
F
L
R
F
L
Q
W
K
W
L
E
A
Q
-
P
M
G
E
D
W
F
L
D
F
R
V
L
G
R
G
G
F
G
E
V
F
A
C
Q
M
---
K
A
T
G
K
L
Y
A
C
K
K
L
N
K
K
R
L
K
K
-
R
K
G
Y
Q
G
A
M
V
E
K
K
I
L
-
A
K
-
V
-
H
S
---
R
---
F
I
V
S
L
A
Y
A
F
E
T
K
T
D
L
C
L
V
M
T
I
M
N
G
G
D
I
R
Y
H
I
Y
N
V
D
E
D
N
P
G
F
Q
E
P
R
A
I
F
Y
T
A
Q
I
V
S
G
L
E
H
L
H
-
Q
-
R
N
I
I
Y
R
D
L
K
P
E
N
V
L
L
D
D
D
G
N
V
R
I
S
D
L
G
L
A
V
E
L
K
A
G
Q
T
K
T
K
G
Y
A
G
T
P
G
F
M
A
P
E
L
L
L
-
G
E
E
Y
D
F
S
V
D
Y
F
A
L
G
V
T
L
Y
E
M
I
A
A
R
G
P
F
R
A
R
G
E
K
V
E
N
K
E
L
K
Q
R
V
L
E
Q
A
V
T
Y
P
D
K
F
S
P
A
S
K
D
F
C
E
A
L
L
Q
K
D
P
E
K
R
L
G
F
R
-
D
-
G
S
C
D
G
L
R
T
H
P
L
F
R
D
I
S
W
R
Q
L
E
A
G
M
L
T
P
P
F
V
P
D
--------
I
Q
D
V
G
A
F
S
---
T
--
V
K
G
V
A
F
E
K
A
D
T
E
F
F
Q
E
F
A
S
G
T
C
P
I
P
W
Q
E
E
M
I
E
T
G
V
F
G
D
L
N
V
W
R
P
---------------------------
4
PsiBlast_PDB
96.44
83%
-107
- C1 -
3C51
1
RK_BOVIN
A:
[31-533]
------------------------------
R
D
R
K
Y
L
A
R
L
K
L
P
P
L
S
K
C
--
E
A
L
R
E
S
L
D
L
G
F
E
G
M
C
L
E
Q
P
I
G
K
R
L
F
Q
Q
F
-
L
R
T
H
E
Q
H
G
P
A
L
Q
L
W
----
K
D
I
E
D
Y
D
T
A
D
D
A
L
R
P
-
Q
K
-
A
Q
A
L
R
A
A
Y
L
E
P
Q
A
Q
L
F
C
S
F
L
D
A
E
T
V
A
----
R
A
R
A
G
----------
G
--
L
F
Q
P
L
L
R
A
V
L
A
H
L
G
Q
A
P
F
Q
E
F
L
D
S
L
Y
F
L
R
F
L
Q
W
K
W
L
E
A
Q
-
P
M
G
E
D
W
F
L
D
F
R
V
L
G
R
G
G
F
G
E
V
F
A
C
Q
M
---
K
A
T
G
K
L
Y
A
C
K
K
L
N
K
K
R
L
K
K
-
R
K
G
Y
Q
G
A
M
V
E
K
K
I
L
-
A
K
-
V
-
H
S
---
R
---
F
I
V
S
L
A
Y
A
F
E
T
K
T
D
L
C
L
V
M
T
I
M
N
G
G
D
I
R
Y
H
I
Y
N
V
D
E
D
N
P
G
F
Q
E
P
R
A
I
F
Y
T
A
Q
I
V
S
G
L
E
H
L
H
-
Q
-
R
N
I
I
Y
R
D
L
K
P
E
N
V
L
L
D
D
D
G
N
V
R
I
S
D
L
G
L
A
V
E
L
K
A
G
Q
T
K
T
K
G
Y
A
G
T
P
G
F
M
A
P
E
L
L
L
-
G
E
E
Y
D
F
S
V
D
Y
F
A
L
G
V
T
L
Y
E
M
I
A
A
R
G
P
F
R
A
R
G
E
K
V
E
N
K
E
L
K
Q
R
V
L
E
Q
A
V
T
Y
P
D
K
F
S
P
A
S
K
D
F
C
E
A
L
L
Q
K
D
P
E
K
R
L
G
F
R
-
D
-
G
S
C
D
G
L
R
T
H
P
L
F
R
D
I
S
W
R
Q
L
E
A
G
M
L
T
P
P
F
V
P
D
S
R
-------------
S
---
T
--
V
K
G
V
A
F
E
K
A
D
T
E
F
F
Q
E
F
A
S
G
T
C
P
I
P
W
Q
E
E
M
I
E
T
G
V
F
G
D
L
N
V
W
R
P
---------------------------
80
Fugue
84.13
48%
-100
- C1 -
2ACX
1
GRK6_HUMAN
A:
[14-532]
-------------------------
K
A
R
K
G
K
S
K
K
W
R
Q
M
L
Q
F
P
H
I
S
Q
C
--
E
E
L
R
L
S
L
E
R
D
Y
H
S
L
C
E
R
N
P
I
G
R
L
L
F
R
E
F
-
C
A
T
R
P
E
L
S
R
C
V
A
F
L
----
D
G
V
A
E
Y
E
V
T
P
D
D
K
R
K
-
A
C
-
G
R
N
L
T
Q
N
F
L
S
H
T
G
P
D
L
I
P
E
V
P
R
Q
L
V
T
----
N
C
T
Q
R
L
E
---
Q
G
P
C
K
D
--
L
F
Q
E
L
T
R
L
T
H
E
Y
L
S
V
A
P
F
A
D
Y
L
D
S
I
Y
F
N
R
F
L
Q
W
K
W
L
E
R
Q
-
P
V
T
K
N
T
F
R
Q
Y
R
V
L
G
K
G
G
F
G
E
V
C
A
C
Q
V
---
R
A
T
G
K
M
Y
A
C
K
K
L
E
K
K
R
I
K
K
-
R
K
G
E
A
M
A
L
N
E
K
Q
I
L
-
E
K
-
V
-
N
S
---
R
---
F
V
V
S
L
A
Y
A
Y
E
T
K
D
A
L
C
L
V
L
T
L
M
N
G
G
D
L
K
F
H
I
Y
H
M
G
Q
--
A
G
F
P
E
A
R
A
V
F
Y
A
A
E
I
C
C
G
L
E
D
L
H
-
R
-
E
R
I
V
Y
R
D
L
K
P
E
N
I
L
L
D
D
H
G
H
I
R
I
S
D
L
G
L
A
V
H
V
P
E
G
Q
-
T
I
K
G
R
V
G
T
V
G
Y
M
A
P
E
V
V
K
-
N
E
R
Y
T
F
S
P
D
W
W
A
L
G
C
L
L
Y
E
M
I
A
G
Q
S
P
F
Q
Q
R
K
K
K
I
K
R
E
E
V
E
R
L
V
K
E
V
P
E
E
Y
S
E
R
F
S
P
Q
A
R
S
L
C
S
Q
L
L
C
K
D
P
A
E
R
L
G
C
R
-
G
-
G
S
A
R
E
V
K
E
H
P
L
F
K
K
L
N
F
K
R
L
G
A
G
M
L
E
P
P
F
K
P
D
P
Q
A
I
Y
C
E
----------------------
P
T
D
Q
D
F
Y
Q
K
F
A
T
G
S
V
P
I
P
W
Q
N
E
M
V
E
T
E
C
F
Q
E
L
N
V
F
G
L
D
G
S
------------------------
89
HHSearch
84.11
47%
-101
- C1 -
2ACX
1
GRK6_HUMAN
A:
[14-532]
----------------
K
A
R
---------
K
G
K
S
K
K
W
R
Q
M
L
Q
F
P
H
I
S
Q
C
--
E
E
L
R
L
S
L
E
R
D
Y
H
S
L
C
E
R
N
P
I
G
R
L
L
F
R
E
F
-
C
A
T
R
P
E
L
S
R
C
V
A
F
L
----
D
G
V
A
E
Y
E
V
T
P
D
D
K
R
K
-
A
C
-
G
R
N
L
T
Q
N
F
L
S
H
T
G
P
D
L
I
P
E
V
P
R
Q
L
V
T
----
N
C
T
Q
R
L
E
Q
--
G
P
C
-
K
D
--
L
F
Q
E
L
T
R
L
T
H
E
Y
L
S
V
A
P
F
A
D
Y
L
D
S
I
Y
F
N
R
F
L
Q
W
K
W
L
E
R
Q
-
P
V
T
K
N
T
F
R
Q
Y
R
V
L
G
K
G
G
F
G
E
V
C
A
C
Q
V
---
R
A
T
G
K
M
Y
A
C
K
K
L
E
K
K
R
I
K
K
-
R
K
G
E
A
M
A
L
N
E
K
Q
I
L
-
E
K
-
V
-
N
S
---
R
---
F
V
V
S
L
A
Y
A
Y
E
T
K
D
A
L
C
L
V
L
T
L
M
N
G
G
D
L
K
F
H
I
Y
H
M
G
--
Q
A
G
F
P
E
A
R
A
V
F
Y
A
A
E
I
C
C
G
L
E
D
L
H
-
R
-
E
R
I
V
Y
R
D
L
K
P
E
N
I
L
L
D
D
H
G
H
I
R
I
S
D
L
G
L
A
V
H
V
P
E
G
Q
T
-
I
K
G
R
V
G
T
V
G
Y
M
A
P
E
V
V
K
-
N
E
R
Y
T
F
S
P
D
W
W
A
L
G
C
L
L
Y
E
M
I
A
G
Q
S
P
F
Q
Q
R
K
K
K
I
K
R
E
E
V
E
R
L
V
K
E
V
P
E
E
Y
S
E
R
F
S
P
Q
A
R
S
L
C
S
Q
L
L
C
K
D
P
A
E
R
L
G
C
R
-
G
-
G
S
A
R
E
V
K
E
H
P
L
F
K
K
L
N
F
K
R
L
G
A
G
M
L
E
P
P
F
K
P
D
P
Q
A
I
Y
C
----------------------
E
P
T
D
Q
D
F
Y
Q
K
F
A
T
G
S
V
P
I
P
W
Q
N
E
M
V
E
T
E
C
F
Q
E
L
N
V
F
G
L
D
G
S
------------------------
13
PsiBlast_PDB
83.81
48%
-101
- C1 -
2ACX
1
GRK6_HUMAN
A:
[14-532]
----------------
K
A
R
---------
K
G
K
S
K
K
W
R
Q
M
L
Q
F
P
H
I
S
Q
C
--
E
E
L
R
L
S
L
E
R
D
Y
H
S
L
C
E
R
N
P
I
G
R
L
L
F
R
E
F
-
C
A
T
R
P
E
L
S
R
C
V
A
F
L
----
D
G
V
A
E
Y
E
V
T
P
D
D
K
R
K
-
A
C
-
G
R
N
L
T
Q
N
F
L
S
H
T
G
P
D
L
I
P
E
V
P
R
Q
L
V
T
N
C
T
Q
R
L
E
Q
G
P
C
---
K
----
D
--
L
F
Q
E
L
T
R
L
T
H
E
Y
L
S
V
A
P
F
A
D
Y
L
D
S
I
Y
F
N
R
F
L
Q
W
K
W
L
E
R
Q
-
P
V
T
K
N
T
F
R
Q
Y
R
V
L
G
K
G
G
F
G
E
V
C
A
C
Q
V
---
R
A
T
G
K
M
Y
A
C
K
K
L
E
K
K
R
I
K
K
-
R
K
G
E
A
M
A
L
N
E
K
Q
I
L
-
E
K
-
V
-
N
S
---
R
---
F
V
V
S
L
A
Y
A
Y
E
T
K
D
A
L
C
L
V
L
T
L
M
N
G
G
D
L
K
F
H
I
Y
H
M
G
Q
A
--
G
F
P
E
A
R
A
V
F
Y
A
A
E
I
C
C
G
L
E
D
L
H
-
R
-
E
R
I
V
Y
R
D
L
K
P
E
N
I
L
L
D
D
H
G
H
I
R
I
S
D
L
G
L
A
V
H
V
P
E
G
Q
T
-
I
K
G
R
V
G
T
V
G
Y
M
A
P
E
V
V
K
-
N
E
R
Y
T
F
S
P
D
W
W
A
L
G
C
L
L
Y
E
M
I
A
G
Q
S
P
F
Q
Q
R
K
K
K
I
K
R
E
E
V
E
R
L
V
K
E
V
P
E
E
Y
S
E
R
F
S
P
Q
A
R
S
L
C
S
Q
L
L
C
K
D
P
A
E
R
L
G
C
R
-
G
-
G
S
A
R
E
V
K
E
H
P
L
F
K
K
L
N
F
K
R
L
G
A
G
M
L
E
P
P
F
K
P
D
P
Q
A
I
Y
C
----------------------
E
P
T
D
Q
D
F
Y
Q
K
F
A
T
G
S
V
P
I
P
W
Q
N
E
M
V
E
T
E
C
F
Q
E
L
N
V
F
G
L
D
G
S
------------------------
31
PsiBlast_CBE
83.63
48%
-102
- C1 -
2ACX
1
GRK6_HUMAN
B:
[14-535]
----------------
K
A
R
---------
K
G
K
S
K
K
W
R
Q
M
L
Q
F
P
H
I
S
Q
C
--
E
E
L
R
L
S
L
E
R
D
Y
H
S
L
C
E
R
N
P
I
G
R
L
L
F
R
E
F
-
C
A
T
R
P
E
L
S
R
C
V
A
F
L
----
D
G
V
A
E
Y
E
V
T
P
D
D
K
R
K
-
A
C
-
G
R
N
L
T
Q
N
F
L
S
H
T
G
P
D
L
I
P
E
V
P
R
Q
L
V
T
N
C
T
Q
R
L
E
Q
G
P
C
---
K
----
D
--
L
F
Q
E
L
T
R
L
T
H
E
Y
L
S
V
A
P
F
A
D
Y
L
D
S
I
Y
F
N
R
F
L
Q
W
K
W
L
E
R
Q
-
P
V
T
K
N
T
F
R
Q
Y
R
V
L
G
K
G
G
F
G
E
V
C
A
C
Q
V
---
R
A
T
G
K
M
Y
A
C
K
K
L
E
K
K
R
I
K
K
-
R
K
G
E
A
M
A
L
N
E
K
Q
I
L
-
E
K
-
V
-
N
S
---
R
---
F
V
V
S
L
A
Y
A
Y
E
T
K
D
A
L
C
L
V
L
T
L
M
N
G
G
D
L
K
F
H
I
Y
H
M
--
A
--
G
F
P
E
A
R
A
V
F
Y
A
A
E
I
C
C
G
L
E
D
L
H
-
R
-
E
R
I
V
Y
R
D
L
K
P
E
N
I
L
L
D
D
H
G
H
I
R
I
S
D
L
G
L
A
V
H
V
P
E
G
Q
T
-
I
K
G
R
V
G
T
V
G
Y
M
A
P
E
V
V
K
-
N
E
R
Y
T
F
S
P
D
W
W
A
L
G
C
L
L
Y
E
M
I
A
G
Q
S
P
F
Q
Q
---
K
I
K
R
E
E
V
E
R
L
V
K
E
V
P
E
E
Y
S
E
R
F
S
P
Q
A
R
S
L
C
S
Q
L
L
C
K
D
P
A
E
R
L
G
C
R
-
G
-
G
S
A
R
E
V
K
E
H
P
L
F
K
K
L
N
F
K
R
L
G
A
G
M
L
E
P
P
F
K
P
D
P
Q
A
I
Y
-----------------------
E
P
T
D
Q
D
F
Y
Q
K
F
A
T
G
S
V
P
I
P
W
Q
N
E
M
V
E
T
E
C
F
Q
E
L
N
V
F
G
L
D
G
S
V
P
P
---------------------
8
PsiBlast_PDB
83.25
47%
-104
- C1 -
4WNK
1
GRK5_BOVIN
A:
[24-537]
--------------------------
K
G
K
S
K
K
W
K
E
I
--
L
K
F
P
H
I
N
Q
C
--
E
D
L
R
R
T
I
D
R
D
Y
C
S
L
C
D
K
Q
P
V
G
R
L
L
F
R
Q
F
-
C
E
T
R
P
G
L
E
S
Y
I
Q
F
L
----
D
S
V
A
E
Y
E
V
T
P
D
E
K
L
G
-
E
K
-
G
K
E
I
M
T
K
Y
L
T
P
K
S
P
V
F
I
T
Q
V
G
R
D
L
V
S
----
Q
T
E
E
K
L
L
---
Q
K
P
C
K
E
--
L
F
S
A
C
V
Q
S
V
H
D
Y
L
R
G
E
P
F
H
E
Y
L
D
S
M
Y
F
D
R
F
L
Q
W
K
W
L
E
R
Q
-
P
V
T
K
N
T
F
R
Q
Y
R
V
L
G
K
G
G
F
G
E
V
C
A
C
Q
V
---
R
A
T
G
K
M
Y
A
C
K
R
L
E
K
K
R
I
K
K
-
R
K
G
E
S
M
A
L
N
E
K
Q
I
L
-
E
K
-
V
-
N
S
---
R
---
F
V
V
N
L
A
Y
A
Y
E
T
K
D
A
L
C
L
V
L
T
I
M
N
G
G
D
L
K
F
H
I
Y
N
M
G
--
N
P
G
F
E
E
E
R
A
L
F
Y
A
A
E
I
L
C
G
L
E
D
L
H
-
H
-
E
N
I
V
Y
R
D
L
K
P
E
N
I
L
L
D
D
Y
G
H
I
R
I
S
D
L
G
L
A
V
K
I
P
E
G
D
L
-
I
R
G
R
V
G
T
V
G
Y
M
A
P
E
V
L
N
-
N
Q
R
Y
G
L
S
P
D
Y
W
G
L
G
C
L
I
Y
E
M
I
E
G
Q
S
P
F
R
G
R
K
E
K
V
K
R
E
E
V
D
R
R
V
L
E
T
E
E
V
Y
S
H
K
F
S
E
E
A
K
S
I
C
K
M
L
L
T
K
D
A
K
Q
R
L
G
C
Q
-
E
-
E
G
A
A
E
V
K
R
H
P
F
F
R
N
M
N
F
K
R
L
E
A
G
M
L
D
P
P
F
V
P
D
P
R
A
V
Y
------------------------
H
T
D
D
D
F
Y
S
K
F
S
T
G
S
V
P
I
P
W
Q
S
E
M
I
E
T
E
C
F
K
E
L
N
V
F
G
P
H
G
T
L
S
P
D
L
N
R
S
H
---------------
32
PsiBlast_CBE
81.69
47%
-101
- C1 -
4YHJ
1
?
B:
[25-527]
-----------------------------
G
R
S
K
K
W
K
E
I
L
T
L
P
P
V
S
Q
C
--
S
E
L
R
H
S
I
E
K
D
Y
S
S
L
C
D
K
Q
P
I
G
R
R
L
F
R
Q
F
-
C
D
T
K
P
T
L
K
R
H
I
E
F
L
----
D
A
V
A
E
Y
E
V
A
D
D
E
D
R
S
-
D
C
-
G
L
S
I
L
D
R
F
F
N
D
K
L
A
A
P
L
P
E
I
P
P
D
V
V
T
----
E
C
R
L
G
L
K
---
E
E
N
-
P
S
KK
A
F
E
E
C
T
R
V
A
H
N
Y
L
R
G
E
P
F
E
E
Y
Q
E
S
S
Y
F
S
Q
F
L
Q
W
K
W
L
E
R
Q
-
P
V
T
K
N
T
F
R
H
Y
R
V
L
G
K
G
G
F
G
E
V
C
A
C
Q
V
---
R
A
T
G
K
M
Y
A
C
K
K
L
Q
K
K
R
I
K
K
-
R
K
G
E
A
M
A
L
N
E
K
R
I
L
-
E
K
-
V
-
Q
S
---
R
---
F
V
V
S
L
A
Y
A
Y
E
T
K
D
A
L
C
L
V
L
T
I
M
N
G
G
D
L
K
F
H
I
Y
N
L
G
--
N
P
G
F
D
E
Q
R
A
V
F
Y
A
A
E
L
C
C
G
L
E
D
L
Q
-
R
-
E
R
I
V
Y
R
D
L
K
P
E
N
I
L
L
D
D
R
G
H
I
R
I
S
D
L
G
L
A
T
E
I
P
E
G
Q
-
R
V
R
G
R
V
G
T
V
G
Y
M
A
P
E
V
V
N
-
N
E
K
Y
T
F
S
P
D
W
W
G
L
G
C
L
I
Y
E
M
I
Q
G
H
S
P
F
K
K
Y
K
E
K
V
K
W
E
E
V
D
Q
R
I
K
N
D
T
E
E
Y
S
E
K
F
S
E
D
A
K
S
I
C
R
M
L
L
T
K
N
P
S
K
R
L
G
C
R
-
G
-
E
G
A
A
G
V
K
Q
H
P
V
F
K
D
I
N
F
R
R
L
E
A
N
M
L
E
P
P
F
C
P
D
P
H
A
V
Y
C
------------------
G
I
Y
L
D
T
A
D
E
D
F
Y
A
R
F
A
T
G
C
V
S
I
P
W
Q
N
E
M
I
E
S
G
C
F
K
D
I
N
K
------------------------------
14
PsiBlast_PDB
81.61
47%
-99
- C1 -
4YHJ
1
?
A:
[25-525]
-----------------------------
G
R
S
K
K
W
K
E
I
L
T
L
P
P
V
S
Q
C
--
S
E
L
R
H
S
I
E
K
D
Y
S
S
L
C
D
K
Q
P
I
G
R
R
L
F
R
Q
F
-
C
D
T
K
P
T
L
K
R
H
I
E
F
L
----
D
A
V
A
E
Y
E
V
A
D
D
E
D
R
S
-
D
C
-
G
L
S
I
L
D
R
F
F
N
D
K
L
A
A
P
L
P
E
I
P
P
D
V
V
T
----
E
C
R
L
G
L
K
---
E
E
N
-
P
S
KK
A
F
E
E
C
T
R
V
A
H
N
Y
L
R
G
E
P
F
E
E
Y
Q
E
S
S
Y
F
S
Q
F
L
Q
W
K
W
L
E
R
Q
-
P
V
T
K
N
T
F
R
H
Y
R
V
L
G
K
G
G
F
G
E
V
C
A
C
Q
V
---
R
A
T
G
K
M
Y
A
C
K
K
L
Q
K
K
R
I
K
K
-
R
K
G
E
A
M
A
L
N
E
K
R
I
L
-
E
K
-
V
-
Q
S
---
R
---
F
V
V
S
L
A
Y
A
Y
E
T
K
D
A
L
C
L
V
L
T
I
M
N
G
G
D
L
K
F
H
I
Y
N
L
G
--
N
P
G
F
D
E
Q
R
A
V
F
Y
A
A
E
L
C
C
G
L
E
D
L
Q
-
R
-
E
R
I
V
Y
R
D
L
K
P
E
N
I
L
L
D
D
R
G
H
I
R
I
S
D
L
G
L
A
T
E
I
P
E
G
Q
-
R
V
R
G
R
V
G
T
V
G
Y
M
A
P
E
V
V
N
-
N
E
K
Y
T
F
S
P
D
W
W
G
L
G
C
L
I
Y
E
M
I
Q
G
H
S
P
F
K
K
Y
K
E
K
V
K
W
E
E
V
D
Q
R
I
K
N
D
T
E
E
Y
S
E
K
F
S
E
D
A
K
S
I
C
R
M
L
L
T
K
N
P
S
K
R
L
G
C
R
-
G
-
E
G
A
A
G
V
K
Q
H
P
V
F
K
D
I
N
F
R
R
L
E
A
N
M
L
E
P
P
F
C
P
D
P
H
A
V
Y
C
K
D
V
L
D
I
E
Q
F
S
---
V
--
V
K
G
I
Y
L
D
T
A
D
E
D
F
Y
A
R
F
A
T
G
C
V
S
I
P
W
Q
N
E
M
I
E
S
G
C
F
K
D
I
--------------------------------
10
PsiBlast_PDB
81.54
47%
-92
- C1 -
4TND
1
GRK5_HUMAN
A:
[15-537]
-----------------
A
R
E
G
G
G
G
K
R
K
G
K
S
K
K
W
K
E
I
--
L
K
F
P
H
I
S
Q
C
--
E
D
L
R
R
T
I
D
R
D
Y
C
S
L
C
D
K
Q
P
I
G
R
L
L
F
R
Q
F
-
C
E
T
R
----
P
G
L
E
C
Y
I
Q
F
L
D
S
V
A
E
Y
E
V
T
P
D
E
K
L
G
-
E
K
-
G
K
K
I
M
T
K
Y
L
T
P
K
S
P
V
F
I
A
Q
V
G
Q
D
L
V
S
----
Q
T
E
E
K
L
L
---
Q
K
P
C
K
E
--
L
F
S
A
C
A
Q
S
V
H
E
Y
L
R
G
E
P
F
H
E
Y
L
D
S
M
F
F
D
R
F
L
Q
W
K
W
L
E
R
Q
-
P
V
T
K
N
T
F
R
Q
Y
R
V
L
G
K
G
G
F
G
E
V
C
A
C
Q
V
---
R
A
T
G
K
M
Y
A
C
K
R
L
E
K
K
R
I
K
K
-
R
K
G
E
S
M
A
L
N
E
K
Q
I
L
-
E
K
-
V
-
N
S
---
Q
---
F
V
V
N
L
A
Y
A
Y
E
T
K
D
A
L
C
L
V
L
T
I
M
N
G
G
D
L
K
F
H
I
Y
N
M
G
--
N
P
G
F
E
E
E
R
A
L
F
Y
A
A
E
I
L
C
G
L
E
D
L
H
-
H
-
E
N
T
V
Y
R
D
L
K
P
E
N
I
L
L
D
D
Y
G
H
I
R
I
S
D
L
G
L
A
V
K
I
P
E
G
D
L
-
I
R
G
R
V
G
T
V
G
Y
M
A
P
E
V
L
N
-
N
Q
R
Y
G
L
S
P
D
Y
W
G
L
G
C
L
I
Y
E
M
I
E
G
Q
S
P
F
R
G
R
K
E
K
V
K
R
E
E
V
D
R
R
V
L
E
T
E
E
V
Y
S
H
K
F
S
E
E
A
K
S
I
C
K
M
L
L
T
K
D
A
K
Q
R
L
G
C
Q
-
E
-
E
E
A
A
E
V
K
R
H
P
F
F
R
N
M
N
F
K
R
L
E
A
G
M
L
D
P
P
F
V
P
D
P
R
A
V
Y
C
K
D
V
L
D
I
E
Q
F
S
---
T
--
V
K
G
V
N
L
D
H
T
D
D
D
F
Y
S
K
F
S
T
G
S
V
S
I
P
W
Q
N
E
M
I
E
T
E
C
F
K
E
L
N
V
F
G
P
N
G
T
L
P
P
D
L
N
R
N
H
P
P
-------------
9
PsiBlast_PDB
81.40
47%
-93
- C1 -
4TNB
1
GRK5_HUMAN
A:
[15-537]
-----------------
A
R
E
G
G
G
G
K
R
K
G
K
S
K
K
W
K
E
I
--
L
K
F
P
H
I
S
Q
C
--
E
D
L
R
R
T
I
D
R
D
Y
C
S
L
C
D
K
Q
P
I
G
R
L
L
F
R
Q
F
-
C
E
T
R
----
P
G
L
E
C
Y
I
Q
F
L
D
S
V
A
E
Y
E
V
T
P
D
E
K
L
G
-
E
K
-
G
K
K
I
M
T
K
Y
L
T
P
K
S
P
V
F
I
A
Q
V
G
Q
D
L
V
S
----
Q
T
E
E
K
L
L
---
Q
K
P
C
K
E
--
L
F
S
A
C
A
Q
S
V
H
E
Y
L
R
G
E
P
F
H
E
Y
L
D
S
M
F
F
D
R
F
L
Q
W
K
W
L
E
R
Q
-
P
V
T
K
N
T
F
R
Q
Y
R
V
L
G
K
G
G
F
G
E
V
C
A
C
Q
V
---
R
A
T
G
K
M
Y
A
C
K
R
L
E
K
K
R
I
K
K
-
R
K
G
E
S
M
A
L
N
E
K
Q
I
L
-
E
K
-
V
-
N
S
---
Q
---
F
V
V
N
L
A
Y
A
Y
E
T
K
D
A
L
C
L
V
L
T
I
M
N
G
G
D
L
K
F
H
I
Y
N
M
G
--
N
P
G
F
E
E
E
R
A
L
F
Y
A
A
E
I
L
C
G
L
E
D
L
H
-
H
-
E
N
T
V
Y
R
D
L
K
P
E
N
I
L
L
D
D
Y
G
H
I
R
I
S
D
L
G
L
A
V
K
I
P
E
G
D
L
-
I
R
G
R
V
G
T
V
G
Y
M
A
P
E
V
L
N
-
N
Q
R
Y
G
L
S
P
D
Y
W
G
L
G
C
L
I
Y
E
M
I
E
G
Q
S
P
F
R
G
R
K
E
K
V
K
R
E
E
V
D
R
R
V
L
E
T
E
E
V
Y
S
H
K
F
S
E
E
A
K
S
I
C
K
M
L
L
T
K
D
A
K
Q
R
L
G
C
Q
-
E
-
E
E
A
A
E
V
K
R
H
P
F
F
R
N
M
N
F
K
R
L
E
A
G
M
L
D
P
P
F
V
P
D
P
R
A
V
Y
C
K
D
V
L
D
I
E
Q
F
S
---
T
--
V
K
G
V
N
L
D
H
T
D
D
D
F
Y
S
K
F
S
T
G
S
V
S
I
P
W
Q
N
E
M
I
E
T
E
C
F
K
E
L
N
V
F
G
P
N
G
T
L
P
P
D
L
N
R
N
H
P
P
-------------
15
PsiBlast_PDB
71.51
33%
-87
- C1 -
3KRW
1
ARBK1_HUMAN
A:
[29-530]
----------------------------------
K
K
I
L
L
P
E
P
S
I
R
S
V
M
Q
K
Y
L
E
D
R
G
E
V
T
F
E
K
I
-
F
S
Q
K
L
G
Y
L
L
F
R
D
F
C
L
N
H
L
E
E
A
R
P
L
V
E
F
Y
----
E
E
I
K
K
Y
E
K
L
E
T
E
E
E
R
V
A
R
-
S
R
E
I
F
D
S
Y
I
M
K
E
L
-
L
A
--
H
P
F
S
K
S
A
T
----
E
H
V
Q
G
H
L
G
K
K
Q
V
P
-
P
D
--
L
F
Q
P
Y
I
E
E
I
C
Q
N
L
R
G
D
V
F
Q
K
F
I
E
S
D
K
F
T
R
F
C
Q
W
K
N
V
E
L
N
I
H
L
T
M
N
D
F
S
V
H
R
I
I
G
R
G
G
F
G
E
V
Y
G
C
R
K
---
A
D
T
G
K
M
Y
A
M
K
C
L
D
K
K
R
I
K
M
-
K
Q
G
E
T
L
A
L
N
E
R
I
M
L
-
S
L
-
V
-
S
T
GDC
P
---
F
I
V
C
M
S
Y
A
F
H
T
P
D
K
L
S
F
I
L
D
L
M
N
G
G
D
L
H
Y
H
L
----
S
Q
H
G
V
F
S
E
A
D
M
R
F
Y
A
A
E
I
I
L
G
L
E
H
M
H
-
N
-
R
F
V
V
Y
R
D
L
K
P
A
N
I
L
L
D
E
H
G
H
V
R
I
S
D
L
G
L
A
C
D
F
--
S
K
K
K
P
H
A
S
V
G
T
H
G
Y
M
A
P
E
V
L
Q
K
G
V
A
Y
D
S
S
A
D
W
F
S
L
G
C
M
L
F
K
L
L
R
G
H
S
P
F
R
Q
H
K
T
K
-
D
K
H
E
I
D
R
M
T
L
T
M
A
V
E
L
P
D
S
F
S
P
E
L
R
S
L
L
E
G
L
L
Q
R
D
V
N
R
R
L
G
C
L
-
G
-
R
G
A
Q
E
V
K
E
S
P
F
F
R
S
L
D
W
Q
M
V
F
L
Q
K
Y
P
P
P
L
I
P
P
R
------------------
E
ED
T
K
G
I
K
L
L
D
S
D
Q
E
L
Y
R
N
F
P
L
-
T
I
S
E
R
W
Q
Q
E
V
A
E
T
-
V
F
D
T
I
N
A
E
T
D
R
L
E
A
R
K
K
A
K
N
K
Q
L
G
H
E
E
D
Y
A
L
G
K
D
C
I
M
16
PsiBlast_PDB
71.29
33%
-86
- C1 -
3KRX
1
ARBK1_HUMAN
A:
[29-530]
----------------------------------
K
K
I
L
L
P
E
P
S
I
R
S
V
M
Q
K
Y
L
E
D
R
G
E
V
T
F
E
K
I
-
F
S
Q
K
L
G
Y
L
L
F
R
D
F
C
L
N
H
L
E
E
A
R
P
L
V
E
F
Y
----
E
E
I
K
K
Y
E
K
L
E
T
E
E
E
R
V
A
R
-
S
R
E
I
F
D
S
Y
I
M
K
E
L
-
L
A
--
H
P
F
S
K
S
A
T
----
E
H
V
Q
G
H
L
G
K
K
Q
V
P
-
P
D
--
L
F
Q
P
Y
I
E
E
I
C
Q
N
L
R
G
D
V
F
Q
K
F
I
E
S
D
K
F
T
R
F
C
Q
W
K
N
V
E
L
N
I
H
L
T
M
N
D
F
S
V
H
R
I
I
G
R
G
G
F
G
E
V
Y
G
C
R
K
---
A
D
T
G
K
M
Y
A
M
K
C
L
D
K
K
R
I
K
M
-
K
Q
G
E
T
L
A
L
N
E
R
I
M
L
-
S
L
-
V
-
S
T
GDC
P
---
F
I
V
C
M
S
Y
A
F
H
T
P
D
K
L
S
F
I
L
D
L
M
N
G
G
D
L
H
Y
H
L
----
S
Q
H
G
V
F
S
E
A
D
M
R
F
Y
A
A
E
I
I
L
G
L
E
H
M
H
-
N
-
R
F
V
V
Y
R
D
L
K
P
A
N
I
L
L
D
E
H
G
H
V
R
I
S
D
L
G
L
A
C
D
F
--
S
K
K
K
P
H
A
S
V
G
T
H
G
Y
M
A
P
E
V
L
Q
K
G
V
A
Y
D
S
S
A
D
W
F
S
L
G
C
M
L
F
K
L
L
R
G
H
S
P
F
R
Q
H
K
T
K
-
D
K
H
E
I
D
R
M
T
L
T
M
A
V
E
L
P
D
S
F
S
P
E
L
R
S
L
L
E
G
L
L
Q
R
D
V
N
R
R
L
G
C
L
-
G
-
R
G
A
Q
E
V
K
E
S
P
F
F
R
S
L
D
W
Q
M
V
F
L
Q
K
Y
P
P
P
L
I
P
P
R
------------------
E
ED
T
K
G
I
K
L
L
D
S
D
Q
E
L
Y
R
N
F
P
L
-
T
I
S
E
R
W
Q
Q
E
V
A
E
T
-
V
F
D
T
I
N
A
E
T
D
R
L
E
A
R
K
K
A
K
N
K
Q
L
G
H
E
E
D
Y
A
L
G
K
D
C
I
M
36
PsiBlast_CBE
70.85
33%
-95
- C1 -
3PVU
1
ARBK1_BOVIN
A:
[30-530]
----------------------------------
K
K
I
L
L
P
E
P
S
I
R
S
V
M
Q
K
Y
L
E
D
R
G
E
V
T
F
E
K
I
-
F
S
Q
K
L
G
Y
L
L
F
R
D
F
C
L
K
H
L
E
E
A
K
P
L
V
E
F
Y
----
E
E
I
K
K
Y
E
K
L
E
T
E
E
E
R
-
L
V
C
S
R
E
I
F
D
T
Y
I
M
K
E
L
-
L
A
C
S
H
P
F
S
K
S
A
I
----
E
H
V
Q
G
H
L
V
K
K
Q
V
P
-
P
D
--
L
F
Q
P
Y
I
E
E
I
C
Q
N
L
R
G
D
V
F
Q
K
F
I
E
S
D
K
F
T
R
F
C
Q
W
K
N
V
E
L
N
I
H
L
T
M
N
D
F
S
V
H
R
I
I
G
R
G
G
F
G
E
V
Y
G
C
R
K
---
A
D
T
G
K
M
Y
A
M
K
C
L
D
K
K
R
I
K
M
-
K
Q
G
E
T
L
A
L
N
E
R
I
M
L
-
S
L
-
V
-
S
T
GDC
P
---
F
I
V
C
M
S
Y
A
F
H
T
P
D
K
L
S
F
I
L
D
L
M
N
G
G
D
L
H
Y
H
L
----
S
Q
H
G
V
F
S
E
A
D
M
R
F
Y
A
A
E
I
I
L
G
L
E
H
M
H
-
N
-
R
F
V
V
Y
R
D
L
K
P
A
N
I
L
L
D
E
H
G
H
V
R
I
S
D
L
G
L
A
C
D
F
--
S
K
K
K
P
H
A
S
V
G
T
H
G
Y
M
A
P
E
V
L
Q
K
G
V
A
Y
D
S
S
A
D
W
F
S
L
G
C
M
L
F
K
L
L
R
G
H
S
P
F
R
Q
H
K
T
K
-
D
K
H
E
I
D
R
M
T
L
T
M
A
V
E
L
P
D
S
F
S
P
E
L
R
S
L
L
E
G
L
L
Q
R
D
V
N
R
R
L
G
C
L
-
G
-
R
G
A
Q
E
V
K
E
S
P
F
F
R
S
L
D
W
Q
M
V
F
L
Q
K
Y
P
P
P
L
I
P
P
R
G
---------------------------
D
S
D
Q
E
L
Y
R
N
F
P
L
-
T
I
S
E
R
W
Q
Q
E
V
A
E
T
-
V
F
D
T
I
N
A
E
T
D
R
L
E
A
R
K
K
T
K
N
K
Q
L
G
H
E
E
D
Y
A
L
G
K
D
C
I
M
35
PsiBlast_CBE
69.88
33%
-92
- C1 -
3PVW
1
ARBK1_BOVIN
A:
[29-530]
---------------------------------
S
K
K
I
L
L
P
E
P
S
I
R
S
V
M
Q
K
Y
L
E
D
R
G
E
V
T
F
E
K
I
-
F
S
Q
K
L
G
Y
L
L
F
R
D
F
C
L
K
H
L
E
E
A
K
P
L
V
E
F
Y
----
E
E
I
K
K
Y
E
K
L
E
T
E
E
E
R
-
L
V
C
S
R
E
I
F
D
T
Y
I
M
K
E
L
-
L
A
C
S
H
P
F
S
K
S
A
I
----
E
H
V
Q
G
H
L
V
K
K
Q
V
P
-
P
D
--
L
F
Q
P
Y
I
E
E
I
C
Q
N
L
R
G
D
V
F
Q
K
F
I
E
S
D
K
F
T
R
F
C
Q
W
K
N
V
E
L
N
I
H
L
T
M
N
D
F
S
V
H
R
I
I
G
R
G
G
F
G
E
V
Y
G
C
R
K
---
A
D
T
G
K
M
Y
A
M
K
C
L
D
K
K
R
I
K
M
-
K
Q
G
E
T
L
A
L
N
E
R
I
M
L
-
S
L
-
V
-
S
T
GDC
P
---
F
I
V
C
M
S
Y
A
F
H
T
P
D
K
L
S
F
I
L
D
L
M
N
G
G
D
L
H
Y
H
L
----
S
Q
H
G
V
F
S
E
A
D
M
R
F
Y
A
A
E
I
I
L
G
L
E
H
M
H
-
N
-
R
F
V
V
Y
R
D
L
K
P
A
N
I
L
L
D
E
H
G
H
V
R
I
S
D
L
G
L
A
C
D
F
--
S
K
K
K
P
H
A
S
V
G
T
H
G
Y
M
A
P
E
V
L
Q
K
G
V
A
Y
D
S
S
A
D
W
F
S
L
G
C
M
L
F
K
L
L
R
G
H
S
P
F
R
Q
H
K
T
K
-
D
K
H
E
I
D
R
M
T
L
T
M
A
V
E
L
P
D
S
F
S
P
E
L
R
S
L
L
E
G
L
L
Q
R
D
V
N
R
R
L
G
C
L
-
G
-
R
G
A
Q
E
V
K
E
S
P
F
F
R
S
L
D
W
Q
M
V
F
L
Q
K
Y
P
P
P
L
I
P
P
R
G
------------------------
K
L
L
D
S
D
Q
E
L
Y
R
N
F
P
L
-
T
I
S
E
R
W
Q
Q
E
V
A
E
T
-
V
F
D
T
I
N
A
E
T
D
R
L
E
A
R
K
K
T
K
N
K
Q
L
G
H
E
E
D
Y
A
L
G
K
D
C
I
M
18
PsiBlast_PDB
68.68
33%
-90
- C1 -
4PNK
1
ARBK1_HUMAN
A:
[30-531]
----------------------------------
K
K
I
L
L
P
E
P
S
I
R
S
V
M
Q
K
Y
L
E
D
R
G
E
V
T
F
E
K
I
-
F
S
Q
K
L
G
Y
L
L
F
R
D
F
C
L
N
H
L
E
E
A
R
P
L
V
E
F
Y
----
E
E
I
K
K
Y
E
K
L
E
T
E
E
E
R
V
A
R
-
S
R
E
I
F
D
S
Y
I
M
K
E
L
-
L
A
C
S
H
P
F
S
K
S
A
T
----
E
H
V
Q
G
H
L
G
K
K
Q
V
P
-
P
D
--
L
F
Q
P
Y
I
E
E
I
C
Q
N
L
R
G
D
V
F
Q
K
F
I
E
S
D
K
F
T
R
F
C
Q
W
K
N
V
E
L
N
I
H
L
T
M
N
D
F
S
V
H
R
I
I
G
R
G
G
F
G
E
V
Y
G
C
R
K
---
A
D
T
G
K
M
Y
A
M
K
C
L
D
K
K
R
I
K
M
-
K
Q
G
E
T
L
A
L
N
E
R
I
M
L
-
S
L
-
V
-
S
T
GDC
P
---
F
I
V
C
M
S
Y
A
F
H
T
P
D
K
L
S
F
I
L
D
L
M
N
G
G
D
L
H
Y
H
L
----
S
Q
H
G
V
F
S
E
A
D
M
R
F
Y
A
A
E
I
I
L
G
L
E
H
M
H
-
N
-
R
F
V
V
Y
R
D
L
K
P
A
N
I
L
L
D
E
H
G
H
V
R
I
S
D
L
G
L
A
C
D
F
--
S
K
K
K
P
H
A
S
V
G
T
H
G
Y
M
A
P
E
V
L
Q
K
G
V
A
Y
D
S
S
A
D
W
F
S
L
G
C
M
L
F
K
L
L
R
G
H
S
P
F
R
Q
H
K
T
K
-
D
K
H
E
I
D
R
M
T
L
T
M
A
V
E
L
P
D
S
F
S
P
E
L
R
S
L
L
E
G
L
L
Q
R
D
V
N
R
R
L
G
C
L
-
G
-
R
G
A
Q
E
V
K
E
S
P
F
F
R
S
L
D
W
Q
M
V
F
L
Q
K
Y
P
P
P
L
I
P
P
R
-
E
V
N
A
----------------
T
K
G
I
K
L
L
D
S
D
Q
E
L
Y
R
N
F
P
L
-
T
I
S
E
R
W
Q
Q
E
V
A
E
T
-
V
F
D
T
I
N
A
E
T
D
R
L
E
A
R
K
K
A
K
N
K
Q
L
G
H
E
E
D
Y
A
L
G
K
D
C
I
M
19
PsiBlast_PDB
67.21
34%
-85
- C1 -
4MK0
1
ARBK1_HUMAN
A:
[18-502]
---------------------------------------------------
L
E
D
R
G
E
V
T
F
E
K
I
-
F
S
Q
K
L
G
Y
L
L
F
R
D
F
C
L
N
H
L
E
E
A
R
P
L
V
E
F
Y
----
E
E
I
K
K
Y
E
K
L
E
T
E
E
E
R
V
A
R
-
S
R
E
I
F
D
S
Y
I
M
K
E
L
-
L
A
C
S
H
P
F
S
K
S
A
T
----
E
H
V
Q
G
H
L
G
K
K
Q
V
P
-
P
D
--
L
F
Q
P
Y
I
E
E
I
C
Q
N
L
R
G
D
V
F
Q
K
F
I
E
S
D
K
F
T
R
F
C
Q
W
K
N
V
E
L
N
I
H
L
T
M
N
D
F
S
V
H
R
I
I
G
R
G
G
F
G
E
V
Y
G
C
R
K
---
A
D
T
G
K
M
Y
A
M
K
C
L
D
K
K
R
I
K
M
-
K
Q
G
E
T
L
A
L
N
E
R
I
M
L
-
S
L
-
V
-
S
T
GDC
P
---
F
I
V
C
M
S
Y
A
F
H
T
P
D
K
L
S
F
I
L
D
L
M
N
G
G
D
L
H
Y
H
L
----
S
Q
H
G
V
F
S
E
A
D
M
R
F
Y
A
A
E
I
I
L
G
L
E
H
M
H
-
N
-
R
F
V
V
Y
R
D
L
K
P
A
N
I
L
L
D
E
H
G
H
V
R
I
S
D
L
G
L
A
C
D
F
--
S
K
K
K
P
H
A
S
V
G
T
H
G
Y
M
A
P
E
V
L
Q
K
G
V
A
Y
D
S
S
A
D
W
F
S
L
G
C
M
L
F
K
L
L
R
G
H
S
P
F
R
Q
H
K
T
K
-
D
K
H
E
I
D
R
M
T
L
T
M
A
V
E
L
P
D
S
F
S
P
E
L
R
S
L
L
E
G
L
L
Q
R
D
V
N
R
R
L
G
C
L
-
G
-
R
G
A
Q
E
V
K
E
S
P
F
F
R
S
L
D
W
Q
M
V
F
L
Q
K
Y
P
P
P
L
I
P
P
R
G
E
V
N
A
A
D
A
F
------------
T
K
G
I
K
L
L
D
S
D
Q
E
L
Y
R
N
F
P
L
-
T
I
S
E
R
W
Q
Q
E
V
A
E
T
-
V
F
D
T
I
N
A
E
T
D
R
L
E
A
R
K
K
A
K
N
K
Q
L
G
H
E
E
D
Y
A
L
G
K
D
C
I
M
94
HHSearch
53.22
34%
-90
- C1 -
1RDQ
3
KAPCA_MOUSE
E:
[29-331]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
W
E
T
P
S
Q
N
-
T
A
Q
L
D
Q
F
D
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
---
K
E
S
G
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
K
-
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
A
-
V
-
N
F
---
P
---
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
R
R
I
----
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
-
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
R
V
K
G
R
---
T
W
T
L
C
G
T
P
E
A
L
A
P
E
I
I
L
-
S
K
G
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
A
D
Q
----
P
I
Q
I
Y
E
K
I
V
S
G
K
V
R
F
P
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
N
L
-
K
-
N
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
-----
G
P
G
D
T
S
N
F
D
---
D
--
Y
E
E
E
E
I
R
V
S
I
N
E
K
C
G
K
E
F
T
E
F
--------------------------------------------------
102
HHSearch
53.07
38%
-107
- C1 -
2R5T
1
SGK1_HUMAN
A:
[35-318]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
K
P
S
D
F
H
F
L
K
V
I
G
K
G
S
F
G
K
V
L
L
A
R
H
---
K
A
E
E
V
F
Y
A
V
K
V
L
Q
K
K
A
I
L
--------------
V
L
L
K
N
-
V
-
K
H
---
P
---
F
L
V
G
L
H
F
S
F
Q
T
A
D
K
L
Y
F
V
L
D
Y
I
N
G
G
E
L
F
Y
H
L
Q
R
----
E
R
C
F
L
E
P
R
A
R
F
Y
A
A
E
I
A
S
A
L
G
Y
L
H
-
S
-
L
N
I
V
Y
R
D
L
K
P
E
N
I
L
L
D
S
Q
G
H
I
V
L
T
D
F
G
L
C
K
E
N
I
E
H
N
S
T
T
S
T
F
C
G
T
P
E
Y
L
A
P
E
V
L
H
-
K
Q
P
Y
D
R
T
V
D
W
W
C
L
G
A
V
L
Y
E
M
L
Y
G
L
P
P
F
Y
S
R
N
----
T
A
E
M
Y
D
N
I
L
N
K
P
L
Q
L
K
P
N
I
T
N
S
A
R
H
L
L
E
G
L
L
Q
K
D
R
T
K
R
L
G
A
K
---
D
D
F
M
E
I
K
S
H
V
F
F
S
L
I
N
W
D
D
L
I
N
K
K
I
T
P
P
F
N
P
N
V
S
G
------------------------------------------------------------------------------------------
97
HHSearch
52.49
37%
-85
- C1 -
3PFQ
1
KPCB_RAT
A:
[341-648]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
D
F
N
F
L
M
V
L
G
K
G
S
F
G
K
V
M
L
S
E
R
---
K
G
T
D
E
L
Y
A
V
K
I
L
K
K
D
V
V
I
Q
-
D
D
D
V
E
C
T
M
V
E
K
R
V
L
-
A
L
-
P
G
K
P
---
P
---
F
L
T
Q
L
H
S
C
F
Q
T
M
D
R
L
Y
F
V
M
E
Y
V
N
G
G
D
L
M
Y
H
I
Q
Q
V
----
G
R
F
K
E
P
H
A
V
F
Y
A
A
E
I
A
I
G
L
F
F
L
Q
-
S
-
K
G
I
I
Y
R
D
L
K
L
D
N
V
M
L
D
S
E
G
H
I
K
I
A
D
F
G
M
C
K
E
N
I
W
D
G
V
T
T
K
T
F
C
G
T
P
D
Y
I
A
P
E
I
I
A
-
Y
Q
P
Y
G
K
S
V
D
W
W
A
F
G
V
L
L
Y
E
M
L
A
G
Q
A
P
F
E
G
E
----
D
E
D
E
L
F
Q
S
I
M
E
H
N
V
A
Y
P
K
S
M
S
K
E
A
V
A
I
C
K
G
L
M
T
K
H
P
G
K
R
L
G
C
G
-
P
-
E
G
E
R
D
I
K
E
H
A
F
F
R
Y
I
D
W
E
K
L
E
R
K
E
I
Q
P
P
Y
K
P
K
A
S
G
R
---
N
A
E
N
F
D
R
F
F
---
T
--
R
H
P
P
V
L
T
P
P
D
Q
E
V
I
R
N
I
D
Q
S
E
F
E
G
F
S
F
V
N
S
E
F
L
K
P
------------------------------------
67
PsiBlast_CBE
52.39
34%
-96
- C1 -
2F7X
1
KAPCA_BOVIN
E:
[42-320]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
Q
F
E
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
---
M
E
T
G
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
K
-
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
A
-
V
-
N
F
---
P
---
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
G
R
----
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
-
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
R
V
---
K
G
R
T
W
T
L
C
G
T
P
E
Y
L
A
P
E
I
I
L
-
S
K
G
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
A
D
----
Q
P
I
Q
I
Y
E
K
I
V
S
G
K
V
R
F
P
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
N
L
-
K
-
N
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
D
Y
E
E
E
---
E
--
I
R
V
S
I
N
E
K
C
G
K
E
F
S
E
F
-------------------------------------------------------
65
PsiBlast_CBE
52.37
34%
-97
- C1 -
2OH0
1
KAPCA_BOVIN
E:
[42-320]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
Q
F
E
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
---
M
E
T
G
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
K
-
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
A
-
V
-
N
F
---
P
---
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
G
R
----
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
-
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
R
V
---
K
G
R
T
W
T
L
C
G
T
P
E
Y
L
A
P
E
I
I
L
-
S
K
G
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
A
D
----
Q
P
I
Q
I
Y
E
K
I
V
S
G
K
V
R
F
P
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
N
L
-
K
-
N
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
D
Y
E
E
E
---
E
--
I
R
V
S
I
N
E
K
C
G
K
E
F
S
E
F
-------------------------------------------------------
60
PsiBlast_CBE
52.34
34%
-96
- C1 -
2UZW
1
KAPCA_BOVIN
E:
[27-305]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
Q
F
E
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
---
M
E
T
G
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
K
-
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
A
-
V
-
N
F
---
P
---
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
G
R
----
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
-
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
R
V
---
K
G
R
T
W
T
L
C
G
T
P
E
Y
L
A
P
E
I
I
L
-
S
K
G
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
A
D
----
Q
P
I
Q
I
Y
E
K
I
V
S
G
K
V
R
F
P
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
N
L
-
K
-
D
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
D
Y
E
E
E
---
E
--
I
R
V
S
I
N
E
K
C
G
K
E
F
S
E
F
-------------------------------------------------------
68
PsiBlast_CBE
52.02
34%
-95
- C1 -
2F7E
1
KAPCA_BOVIN
E:
[42-320]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
Q
F
E
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
---
M
E
T
G
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
K
-
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
A
-
V
-
N
F
---
P
---
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
G
R
----
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
-
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
R
V
---
K
G
R
T
W
T
L
C
G
T
P
E
Y
L
A
P
E
I
I
L
-
S
K
G
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
A
D
----
Q
P
I
Q
I
Y
E
K
I
V
S
G
K
V
R
F
P
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
N
L
-
K
-
N
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
D
Y
E
E
E
---
E
--
I
R
V
S
I
N
E
K
C
G
K
E
F
S
E
F
-------------------------------------------------------
64
PsiBlast_CBE
51.74
34%
-94
- C1 -
2OJF
1
KAPCA_BOVIN
E:
[42-320]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
Q
F
E
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
---
M
E
T
G
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
K
-
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
A
-
V
-
N
F
---
P
---
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
G
R
----
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
-
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
R
V
---
K
G
R
T
W
T
L
C
G
T
P
E
Y
L
A
P
E
I
I
L
-
S
K
G
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
A
D
----
Q
P
I
Q
I
Y
E
K
I
V
S
G
K
V
R
F
P
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
N
L
-
K
-
N
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
D
Y
E
E
E
---
E
--
I
R
V
S
I
N
E
K
C
G
K
E
F
S
E
F
-------------------------------------------------------
63
PsiBlast_CBE
51.55
34%
-95
- C1 -
2UZT
1
KAPCA_BOVIN
A:
[27-305]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
Q
F
E
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
---
M
E
T
G
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
K
-
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
A
-
V
-
N
F
---
P
---
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
G
R
----
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
-
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
R
V
---
K
G
R
T
W
T
L
C
G
T
P
E
Y
L
A
P
E
I
I
L
-
S
K
G
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
A
D
----
Q
P
I
Q
I
Y
E
K
I
V
S
G
K
V
R
F
P
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
N
L
-
K
-
D
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
D
Y
E
E
E
---
E
--
I
R
V
S
I
N
E
K
C
G
K
E
F
S
E
F
-------------------------------------------------------
66
PsiBlast_CBE
51.40
34%
-99
- C1 -
2F7Z
1
KAPCA_BOVIN
E:
[42-320]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
Q
F
E
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
---
M
E
T
G
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
K
-
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
A
-
V
-
N
F
---
P
---
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
G
R
----
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
-
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
R
V
---
K
G
R
T
W
T
L
C
G
T
P
E
Y
L
A
P
E
I
I
L
-
S
K
G
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
A
D
----
Q
P
I
Q
I
Y
E
K
I
V
S
G
K
V
R
F
P
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
N
L
-
K
-
N
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
D
Y
E
E
E
---
E
--
I
R
V
S
I
N
E
K
C
G
K
E
F
S
E
F
-------------------------------------------------------
11
PsiBlast_PDB
51.30
48%
25
- C1 -
3NYN
2
GRK6_HUMAN
A:
[5-537]
-----
L
E
N
I
V
A
N
T
V
L
L
K
A
R
E
G
--
G
G
G
N
R
K
G
K
S
K
K
W
R
Q
M
L
Q
F
P
H
I
S
Q
C
--
E
E
L
R
L
S
L
E
R
D
Y
H
S
L
C
E
R
Q
P
I
G
R
L
L
F
R
E
F
-
C
A
T
R
P
E
L
S
R
C
V
A
F
L
----
D
G
V
A
E
Y
E
V
T
P
D
D
K
R
K
-
A
C
-
G
R
Q
L
T
Q
N
F
L
S
H
T
G
P
D
L
I
P
E
V
P
R
Q
L
V
T
N
C
T
Q
R
L
E
Q
G
P
C
---
K
----
D
--
L
F
Q
E
L
T
R
L
T
H
E
Y
L
S
V
A
P
F
A
D
Y
L
D
S
I
Y
F
N
R
F
L
Q
W
K
W
L
E
R
Q
-
P
V
T
K
N
T
F
R
Q
Y
R
V
L
G
K
G
G
F
G
E
V
C
A
C
Q
V
---
R
A
T
G
K
M
Y
A
C
K
K
L
E
K
K
R
I
K
K
-
R
K
G
E
A
M
A
L
N
E
K
Q
I
L
-
E
K
-
V
-
N
S
---
R
---
F
V
V
S
L
A
Y
A
Y
E
T
K
D
A
L
C
L
V
L
T
L
M
N
G
G
D
L
K
F
H
I
Y
H
M
G
Q
A
--
G
F
P
E
A
R
A
V
F
Y
A
A
E
I
C
C
G
L
E
D
L
H
-
R
-
E
R
I
V
Y
R
D
L
K
P
E
N
I
L
L
D
D
H
G
H
I
R
I
S
D
L
G
L
A
V
H
V
P
E
G
Q
T
-
I
K
G
R
V
G
T
V
G
Y
M
A
P
E
V
V
K
-
N
E
R
Y
T
F
S
P
D
W
W
A
L
G
C
L
L
Y
E
M
I
A
G
Q
S
P
F
Q
---
K
K
I
K
R
E
E
V
E
R
L
V
K
E
V
P
E
E
Y
S
E
R
F
S
P
Q
A
R
S
L
C
S
Q
L
L
C
K
D
P
A
E
R
L
G
C
R
-
G
-
G
S
A
R
E
V
K
E
H
P
L
F
K
K
L
N
F
K
R
L
G
A
G
M
L
E
P
P
F
K
P
D
P
Q
A
I
Y
C
K
D
V
L
D
I
E
Q
F
S
---
T
--
V
K
G
V
E
L
E
P
T
D
Q
D
F
Y
Q
K
F
A
T
G
S
V
P
I
P
W
Q
N
E
M
V
E
T
E
C
F
Q
E
L
N
V
F
G
L
D
G
S
V
P
P
D
L
D
W
K
G
Q
P
P
A
P
P
K
K
G
L
L
Q
R
L
F
62
PsiBlast_CBE
51.28
34%
-94
- C1 -
2UZU
1
KAPCA_BOVIN
E:
[27-305]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
Q
F
E
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
---
M
E
T
G
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
K
-
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
A
-
V
-
N
F
---
P
---
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
G
R
----
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
-
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
R
V
---
K
G
R
T
W
T
L
C
G
T
P
E
Y
L
A
P
E
I
I
L
-
S
K
G
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
A
D
----
Q
P
I
Q
I
Y
E
K
I
V
S
G
K
V
R
F
P
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
N
L
-
K
-
D
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
D
Y
E
E
E
---
E
--
I
R
V
S
I
N
E
K
C
G
K
E
F
S
E
F
-------------------------------------------------------
73
PsiBlast_CBE
51.17
33%
-89
- C1 -
4L3J
1
KS6B1_HUMAN
A:
[14-304]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
I
R
P
E
C
F
E
L
L
R
V
L
G
K
G
G
Y
G
K
V
F
Q
V
R
K
VTG
A
N
T
G
K
I
F
A
M
K
V
L
K
K
A
M
I
V
R
N
A
K
D
T
A
H
T
K
A
E
R
N
I
L
-
E
E
-
V
-
K
H
---
P
---
F
I
V
D
L
I
Y
A
F
Q
T
G
G
K
L
Y
L
I
L
E
Y
L
S
G
G
E
L
F
M
Q
L
----
E
R
E
G
I
F
M
E
D
T
A
C
F
Y
L
A
E
I
S
M
A
L
G
H
L
H
-
Q
-
K
G
I
I
Y
R
D
L
K
P
E
N
I
M
L
N
H
Q
G
H
V
K
L
T
D
F
G
L
C
K
E
S
I
H
D
G
T
V
T
H
T
F
C
G
T
I
E
Y
M
A
P
E
I
L
M
-
R
S
G
H
N
R
A
V
D
W
W
S
L
G
A
L
M
Y
D
M
L
T
G
A
P
P
F
T
G
E
N
----
R
K
K
T
I
D
K
I
L
K
C
K
L
N
L
P
P
Y
L
T
Q
E
A
R
D
L
L
K
K
L
L
K
R
N
A
A
S
R
L
G
A
G
-
P
-
G
D
A
G
E
V
Q
A
H
P
F
F
R
H
I
N
W
E
E
L
L
A
R
K
V
E
P
P
F
K
P
L
L
Q
S
------------------------------------------------------------------------------------------
58
PsiBlast_CBE
51.16
35%
-102
- C1 -
4OTI
1
A:
[5-312]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
K
S
-
P
L
T
L
E
D
F
K
F
L
A
V
L
G
R
G
H
F
G
K
V
L
L
S
E
F
---
R
P
S
G
E
L
F
A
I
K
A
L
K
K
G
D
I
V
A
-
R
D
E
V
E
S
L
M
C
E
K
R
I
L
-
A
A
-
V
-
T
S
---
A
GHP
F
L
V
N
L
F
G
C
F
Q
T
P
E
H
V
C
F
V
M
E
Y
S
A
G
G
D
L
M
L
H
I
H
S
-----
D
V
F
S
E
P
R
A
I
F
Y
S
A
C
V
V
L
G
L
Q
F
L
H
-
E
-
H
K
I
V
Y
R
D
L
K
L
D
N
L
L
L
D
T
E
G
Y
V
K
I
A
D
F
G
L
--------------------------------
T
R
A
V
D
W
W
G
L
G
V
L
L
Y
E
M
L
V
G
E
S
P
F
P
G
D
D
E
----
E
E
V
F
D
S
I
V
N
D
E
V
R
Y
P
R
F
L
S
A
E
A
I
G
I
M
R
R
L
L
R
R
N
P
E
R
R
L
G
S
S
-
E
-
R
D
A
E
D
V
K
K
Q
P
F
F
R
T
L
G
W
E
A
L
L
A
R
R
L
P
P
P
F
V
P
--------------------
T
--
L
S
G
----
R
T
D
V
S
N
F
D
E
E
F
T
G
E
A
P
T
L
S
P
P
R
D
A
R
P
L
T
A
A
E
Q
A
A
F
L
D
F
D
F
V
A
G
---------------------
37
PsiBlast_CBE
51.10
39%
-82
- C1 -
4RA5
1
B:
[11-286]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
M
L
G
K
G
S
F
G
K
V
F
L
A
E
F
---
K
K
T
N
Q
F
F
A
I
K
A
L
K
K
D
V
V
L
M
-
D
D
D
V
E
C
T
M
V
E
K
R
V
L
S
L
A
-
W
-
E
H
---
P
---
F
L
T
H
M
F
C
T
F
Q
T
K
E
N
L
F
F
V
M
E
Y
L
N
G
G
D
L
M
Y
H
I
Q
S
C
H
K
----
F
D
L
S
R
A
T
F
Y
A
A
E
I
I
L
G
L
Q
F
L
H
-
S
-
K
G
I
V
Y
R
D
L
K
L
D
N
I
L
L
D
K
D
G
H
I
K
I
A
D
F
G
M
C
K
E
N
M
L
G
D
A
K
T
N
E
F
C
G
T
P
D
Y
I
A
P
E
I
L
L
-
G
Q
K
Y
N
H
S
V
D
W
W
S
F
G
V
L
L
Y
E
M
L
I
G
Q
S
P
F
H
G
Q
D
E
----
E
E
L
F
H
S
I
R
M
D
N
P
F
Y
P
R
W
L
E
K
E
A
K
D
L
L
V
K
L
F
V
R
E
P
E
K
R
L
G
V
R
-
G
-
D
----
I
R
Q
H
P
L
F
R
E
I
N
W
E
E
L
E
R
K
E
I
D
P
P
F
R
P
K
V
K
S
P
F
D
P
R
L
S
R
A
L
I
N
S
---
M
--
D
Q
N
M
F
R
N
F
S
F
M
N
P
G
M
--------------------------------------------------------
44
PsiBlast_CBE
51.08
38%
-105
- C1 -
2R5T
1
SGK1_HUMAN
A:
[43-317]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
K
V
I
G
K
G
S
F
G
K
V
L
L
A
R
H
---
K
A
E
E
V
F
Y
A
V
K
V
L
Q
K
K
A
I
L
--------------
V
L
-
L
K
N
V
-
K
H
---
P
---
F
L
V
G
L
H
F
S
F
Q
T
A
D
K
L
Y
F
V
L
D
Y
I
N
G
G
E
L
F
Y
H
L
----
Q
R
E
R
C
F
L
E
P
R
A
R
F
Y
A
A
E
I
A
S
A
L
G
Y
L
H
-
S
-
L
N
I
V
Y
R
D
L
K
P
E
N
I
L
L
D
S
Q
G
H
I
V
L
T
D
F
G
L
C
K
E
N
I
E
H
N
S
T
T
S
T
F
C
G
T
P
E
Y
L
A
P
E
V
L
H
-
K
Q
P
Y
D
R
T
V
D
W
W
C
L
G
A
V
L
Y
E
M
L
Y
G
L
P
P
F
Y
S
R
N
----
T
A
E
M
Y
D
N
I
L
N
K
P
L
Q
L
K
P
N
I
T
N
S
A
R
H
L
L
E
G
L
L
Q
K
D
R
T
K
R
L
G
A
K
-
D
-
D
F
M
E
-
I
K
S
H
V
F
F
S
L
I
N
W
D
D
L
I
N
K
K
I
T
P
P
F
N
P
N
V
S
G
------------------------------------------------------------------------------------------
109
HHSearch
50.94
36%
-102
- C1 -
4EJN
3
AKT1_HUMAN
A:
[145-430]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
T
M
N
E
F
E
Y
L
K
L
L
G
K
G
T
F
G
K
V
I
L
V
K
E
---
K
A
T
G
R
Y
Y
A
M
K
I
L
K
K
E
V
I
V
--------------
V
L
-
Q
N
-
S
-
R
H
---
P
---
F
L
T
A
L
K
Y
S
F
Q
T
H
D
R
L
C
F
V
M
E
Y
A
N
G
G
E
L
F
F
H
L
S
R
----
E
R
V
F
S
E
D
R
A
R
F
Y
G
A
E
I
V
S
A
L
D
Y
L
H
-
S
E
K
N
V
V
Y
R
D
L
K
L
E
N
L
M
L
D
K
D
G
H
I
K
I
T
D
F
G
L
C
K
E
G
I
K
-----
K
T
F
C
G
T
P
E
Y
L
A
P
E
V
L
E
-
D
N
D
Y
G
R
A
V
D
W
W
G
L
G
V
V
M
Y
E
M
M
C
G
R
L
P
F
Y
N
Q
----
D
H
E
K
L
F
E
L
I
L
M
E
E
I
R
F
P
R
T
L
G
P
E
A
K
S
L
L
S
G
L
L
K
K
D
P
K
Q
R
L
G
G
G
-
S
-
E
D
A
K
E
I
M
Q
H
R
F
F
A
G
I
V
W
Q
H
V
Y
E
K
K
L
S
P
P
F
K
P
Q
V
T
S
E
T
D
T
R
Y
F
-----------------------------------------------------------------------------------
76
PsiBlast_CBE
50.87
32%
-86
- C1 -
3WF8
2
KS6B1_HUMAN
A:
[15-302]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
I
R
P
E
C
F
E
L
L
R
V
L
G
K
G
G
Y
G
K
V
F
Q
V
R
K
VTG
A
N
T
G
K
I
F
A
M
K
V
L
K
K
A
M
I
V
R
N
A
K
D
T
A
H
T
K
A
E
R
N
I
L
-
E
E
-
V
-
K
H
---
P
---
F
I
V
D
L
I
Y
A
F
Q
T
G
G
K
L
Y
L
I
L
E
Y
L
S
G
G
E
L
F
M
Q
L
----
E
R
E
G
I
F
M
E
D
T
A
C
F
Y
L
A
E
I
S
M
A
L
G
H
L
H
-
Q
-
K
G
I
I
Y
R
D
L
K
P
E
N
I
M
L
N
H
Q
G
H
V
K
L
T
D
F
G
L
C
K
E
S
I
H
D
G
T
V
T
H
T
F
C
G
T
I
E
Y
M
A
P
E
I
L
M
-
R
S
G
H
N
R
A
V
D
W
W
S
L
G
A
L
M
Y
D
M
L
T
G
A
P
P
F
T
G
E
N
----
R
K
K
T
I
D
K
I
L
K
C
K
L
N
L
P
P
Y
L
T
Q
E
A
R
D
L
L
K
K
L
L
K
R
N
A
A
S
R
L
G
A
G
-
P
-
G
D
A
G
E
V
Q
A
H
P
F
F
R
H
I
N
W
E
E
L
L
A
R
K
V
E
P
P
F
K
P
L
---------------------------------------------------------------------------------------------
72
PsiBlast_CBE
50.78
33%
-88
- C1 -
4L3L
1
KS6B1_HUMAN
A:
[14-304]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
I
R
P
E
C
F
E
L
L
R
V
L
G
K
G
G
Y
G
K
V
F
Q
V
R
K
VTG
A
N
T
G
K
I
F
A
M
K
V
L
K
K
A
M
I
V
R
N
A
K
D
T
A
H
T
K
A
E
R
N
I
L
-
E
E
-
V
-
K
H
---
P
---
F
I
V
D
L
I
Y
A
F
Q
T
G
G
K
L
Y
L
I
L
E
Y
L
S
G
G
E
L
F
M
Q
L
----
E
R
E
G
I
F
M
E
D
T
A
C
F
Y
L
A
E
I
S
M
A
L
G
H
L
H
-
Q
-
K
G
I
I
Y
R
D
L
K
P
E
N
I
M
L
N
H
Q
G
H
V
K
L
T
D
F
G
L
C
K
E
S
I
H
D
G
T
V
T
H
T
F
C
G
T
I
E
Y
M
A
P
E
I
L
M
-
R
S
G
H
N
R
A
V
D
W
W
S
L
G
A
L
M
Y
D
M
L
T
G
A
P
P
F
T
G
E
N
----
R
K
K
T
I
D
K
I
L
K
C
K
L
N
L
P
P
Y
L
T
Q
E
A
R
D
L
L
K
K
L
L
K
R
N
A
A
S
R
L
G
A
G
-
P
-
G
D
A
G
E
V
Q
A
H
P
F
F
R
H
I
N
W
E
E
L
L
A
R
K
V
E
P
P
F
K
P
L
L
Q
S
------------------------------------------------------------------------------------------
96
HHSearch
50.72
33%
-84
- C1 -
4DC2
1
KPCI_MOUSE
A:
[50-371]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
L
Q
D
F
D
L
L
R
V
I
G
R
G
S
Y
A
K
V
L
L
V
R
L
---
K
K
T
D
R
I
Y
A
M
R
V
V
K
K
E
L
V
N
-----
I
D
W
V
Q
T
E
K
H
V
F
-
E
Q
-
A
S
N
H
---
P
---
F
L
V
G
L
H
S
C
F
Q
T
E
S
R
L
F
F
V
I
E
Y
V
N
G
G
D
L
M
F
H
M
Q
R
----
Q
R
K
L
P
E
E
H
A
R
F
Y
S
A
E
I
S
L
A
L
N
Y
L
H
-
E
-
R
G
I
I
Y
R
D
L
K
L
D
N
V
L
L
D
S
E
G
H
I
K
L
T
D
Y
G
M
C
K
E
G
L
R
P
G
D
T
T
S
T
F
C
G
T
P
N
Y
I
A
P
E
I
L
R
-
G
E
D
Y
G
F
S
V
D
W
W
A
L
G
V
L
M
F
E
M
M
A
G
R
S
P
F
D
I
V
G
S
-
N
T
E
D
Y
L
F
Q
V
I
L
E
K
Q
I
R
I
P
R
S
L
S
V
K
A
A
S
V
L
K
S
F
L
N
K
D
P
K
E
R
L
G
C
H
P
Q
-
T
G
F
A
D
I
Q
G
H
P
F
F
R
N
V
D
W
D
M
M
E
Q
K
Q
V
V
P
P
F
K
P
N
I
-----
S
G
E
F
G
L
D
N
F
D
SQF
T
--
N
E
P
V
Q
L
T
P
D
D
D
D
I
V
R
K
I
D
Q
S
E
F
E
G
F
E
Y
I
N
P
-----------------------------------------
75
PsiBlast_CBE
50.53
32%
-86
- C1 -
3WF9
2
KS6B1_HUMAN
A:
[15-302]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
I
R
P
E
C
F
E
L
L
R
V
L
G
K
G
G
Y
G
K
V
F
Q
V
R
K
VTG
A
N
T
G
K
I
F
A
M
K
V
L
K
K
A
M
I
V
R
N
A
K
D
T
A
H
T
K
A
E
R
N
I
L
-
E
E
-
V
-
K
H
---
P
---
F
I
V
D
L
I
Y
A
F
Q
T
G
G
K
L
Y
L
I
L
E
Y
L
S
G
G
E
L
F
M
Q
L
----
E
R
E
G
I
F
M
E
D
T
A
C
F
Y
L
A
E
I
S
M
A
L
G
H
L
H
-
Q
-
K
G
I
I
Y
R
D
L
K
P
E
N
I
M
L
N
H
Q
G
H
V
K
L
T
D
F
G
L
C
K
E
S
I
H
D
G
T
V
T
H
T
F
C
G
T
I
E
Y
M
A
P
E
I
L
M
-
R
S
G
H
N
R
A
V
D
W
W
S
L
G
A
L
M
Y
D
M
L
T
G
A
P
P
F
T
G
E
N
----
R
K
K
T
I
D
K
I
L
K
C
K
L
N
L
P
P
Y
L
T
Q
E
A
R
D
L
L
K
K
L
L
K
R
N
A
A
S
R
L
G
A
G
-
P
-
G
D
A
G
E
V
Q
A
H
P
F
F
R
H
I
N
W
E
E
L
L
A
R
K
V
E
P
P
F
K
P
L
---------------------------------------------------------------------------------------------
77
PsiBlast_CBE
50.28
32%
-90
- C1 -
3WF6
1
KS6B1_HUMAN
A:
[15-304]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
I
R
P
E
C
F
E
L
L
R
V
L
G
K
G
G
Y
G
K
V
F
Q
V
R
K
VTG
A
N
T
G
K
I
F
A
M
K
V
L
K
K
------------
T
K
A
E
R
N
I
L
-
E
E
-
V
-
K
H
---
P
---
F
I
V
D
L
I
Y
A
F
Q
T
G
G
K
L
Y
L
I
L
E
Y
L
S
G
G
E
L
F
M
Q
L
----
E
R
E
G
I
F
M
E
D
T
A
C
F
Y
L
A
E
I
S
M
A
L
G
H
L
H
-
Q
-
K
G
I
I
Y
R
D
L
K
P
E
N
I
M
L
N
H
Q
G
H
V
K
L
T
D
F
G
L
C
K
E
S
I
H
D
G
T
V
T
H
T
F
C
G
T
I
E
Y
M
A
P
E
I
L
M
-
R
S
G
H
N
R
A
V
D
W
W
S
L
G
A
L
M
Y
D
M
L
T
G
A
P
P
F
T
G
E
N
----
R
K
K
T
I
D
K
I
L
K
C
K
L
N
L
P
P
Y
L
T
Q
E
A
R
D
L
L
K
K
L
L
K
R
N
A
A
S
R
L
G
A
G
-
P
-
G
D
A
G
E
V
Q
A
H
P
F
F
R
H
I
N
W
E
E
L
L
A
R
K
V
E
P
P
F
K
P
L
L
Q
-------------------------------------------------------------------------------------------
39
PsiBlast_CBE
50.25
39%
-83
- C1 -
4Q9Z
1
B:
[11-286]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
M
L
G
K
G
S
F
G
K
V
F
L
A
E
F
---
K
K
T
N
Q
F
F
A
I
K
A
L
K
K
D
V
V
L
M
-
D
D
D
V
E
C
T
M
V
E
K
R
V
L
S
L
A
-
W
-
E
H
---
P
---
F
L
T
H
M
F
C
T
F
Q
T
K
E
N
L
F
F
V
M
E
Y
L
N
G
G
D
L
M
Y
H
I
Q
S
C
H
K
----
F
D
L
S
R
A
T
F
Y
A
A
E
I
I
L
G
L
Q
F
L
H
-
S
-
K
G
I
V
Y
R
D
L
K
L
D
N
I
L
L
D
K
D
G
H
I
K
I
A
D
F
G
M
C
K
E
N
M
L
G
D
A
K
T
N
E
F
C
G
T
P
D
Y
I
A
P
E
I
L
L
-
G
Q
K
Y
N
H
S
V
D
W
W
S
F
G
V
L
L
Y
E
M
L
I
G
Q
S
P
F
H
G
Q
D
E
----
E
E
L
F
H
S
I
R
M
D
N
P
F
Y
P
R
W
L
E
K
E
A
K
D
L
L
V
K
L
F
V
R
E
P
E
K
R
L
G
V
R
-
G
-
D
----
I
R
Q
H
P
L
F
R
E
I
N
W
E
E
L
E
R
K
E
I
D
P
P
F
R
P
K
V
K
S
P
F
D
C
S
N
F
D
K
N
M
F
R
---
N
--
F
S
F
M
N
P
G
M
E
R
L
------------------------------------------------------------
42
PsiBlast_CBE
50.23
38%
-102
- C1 -
3HDN
1
SGK1_HUMAN
A:
[43-316]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
K
V
I
G
K
G
S
F
G
K
V
L
L
A
R
H
---
K
A
E
E
V
F
Y
A
V
K
V
L
Q
K
K
A
I
L
--------------
V
L
-
L
K
N
V
-
K
H
---
P
---
F
L
V
G
L
H
F
S
F
Q
T
A
D
K
L
Y
F
V
L
D
Y
I
N
G
G
E
L
F
Y
H
L
----
Q
R
E
R
C
F
L
E
P
R
A
R
F
Y
A
A
E
I
A
S
A
L
G
Y
L
H
-
S
-
L
N
I
V
Y
R
D
L
K
P
E
N
I
L
L
D
S
Q
G
H
I
V
L
T
D
F
G
L
C
K
E
N
I
E
H
N
S
T
T
S
T
F
C
G
T
P
E
Y
L
A
P
E
V
L
H
-
K
Q
P
Y
D
R
T
V
D
W
W
C
L
G
A
V
L
Y
E
M
L
Y
G
L
P
P
F
Y
S
R
N
----
T
A
E
M
Y
D
N
I
L
N
K
P
L
Q
L
K
P
N
I
T
N
S
A
R
H
L
L
E
G
L
L
Q
K
D
R
T
K
R
L
G
A
K
-
D
-
D
F
M
E
-
I
K
S
H
V
F
F
S
L
I
N
W
D
D
L
I
N
K
K
I
T
P
P
F
N
P
----------------------------------------------------------------------------------------------
106
HHSearch
49.96
35%
-89
- C1 -
3WF7
2
KS6B1_HUMAN
A:
[15-304]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
I
R
P
E
C
F
E
L
L
R
V
L
G
K
G
G
Y
G
K
V
F
Q
V
R
K
VTG
A
N
T
G
K
I
F
A
M
K
V
L
K
K
A
M
I
V
R
N
A
K
D
T
A
H
T
K
A
E
R
N
I
L
-
E
E
-
V
-
K
H
---
P
---
F
I
V
D
L
I
Y
A
F
Q
T
G
G
K
L
Y
L
I
L
E
Y
L
S
G
G
E
L
F
M
Q
L
E
R
----
E
G
I
F
M
E
D
T
A
C
F
Y
L
A
E
I
S
M
A
L
G
H
L
H
-
Q
-
K
G
I
I
Y
R
D
L
K
P
E
N
I
M
L
N
H
Q
G
H
V
K
L
T
D
F
G
L
C
K
E
S
I
H
D
---
T
H
T
F
C
G
T
I
E
Y
M
A
P
E
I
L
M
-
R
S
G
H
N
R
A
V
D
W
W
S
L
G
A
L
M
Y
D
M
L
T
G
A
P
P
F
T
G
E
N
----
R
K
K
T
I
D
K
I
L
K
C
K
L
N
L
P
P
Y
L
T
Q
E
A
R
D
L
L
K
K
L
L
K
R
N
A
A
S
R
L
G
A
G
-
P
-
G
D
A
G
E
V
Q
A
H
P
F
F
R
H
I
N
W
E
E
L
L
A
R
K
V
E
P
P
F
K
P
L
L
Q
-------------------------------------------------------------------------------------------
69
PsiBlast_CBE
49.60
32%
-95
- C1 -
3A61
1
KS6B1_HUMAN
A:
[15-299]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
P
E
C
F
E
L
L
R
V
L
G
K
G
G
Y
G
K
V
F
Q
V
R
K
V
T
G
A
N
T
G
K
I
F
A
M
K
V
L
K
---------------
A
E
R
N
I
L
-
E
E
-
V
-
K
H
---
P
---
F
I
V
D
L
I
Y
A
F
Q
T
G
G
K
L
Y
L
I
L
E
Y
L
S
G
G
E
L
F
M
Q
L
----
E
R
E
G
I
F
M
E
D
T
A
C
F
Y
L
A
E
I
S
M
A
L
G
H
L
H
-
Q
-
K
G
I
I
Y
R
D
L
K
P
E
N
I
M
L
N
H
Q
G
H
V
K
L
T
D
F
G
----------------
G
T
I
E
Y
M
A
P
E
I
L
M
-
R
S
G
H
N
R
A
V
D
W
W
S
L
G
A
L
M
Y
D
M
L
T
G
A
P
P
F
T
G
E
N
----
R
K
K
T
I
D
K
I
L
K
C
K
L
N
L
P
P
Y
L
T
Q
E
A
R
D
L
L
K
K
L
L
K
R
N
A
A
S
R
L
G
A
G
-
P
-
G
D
A
G
E
V
Q
A
H
P
F
F
R
H
I
N
W
E
E
L
L
A
R
K
V
E
P
P
F
K
P
----------------------------------------------------------------------------------------------
43
PsiBlast_CBE
49.45
38%
-97
- C1 -
3HDM
1
SGK1_HUMAN
A:
[43-317]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
K
V
I
G
K
G
S
F
G
K
V
L
L
A
R
H
---
K
A
E
E
V
F
Y
A
V
K
V
L
Q
K
K
A
I
L
--------------
V
L
-
L
K
N
V
-
K
H
---
P
---
F
L
V
G
L
H
F
S
F
Q
T
A
D
K
L
Y
F
V
L
D
Y
I
N
G
G
E
L
F
Y
H
L
----
Q
R
E
R
C
F
L
E
P
R
A
R
F
Y
A
A
E
I
A
S
A
L
G
Y
L
H
-
S
-
L
N
I
V
Y
R
D
L
K
P
E
N
I
L
L
D
S
Q
G
H
I
V
L
T
D
F
G
L
C
K
E
N
I
E
H
N
S
T
T
S
T
F
C
G
T
P
E
Y
L
A
P
E
V
L
H
-
K
Q
P
Y
D
R
T
V
D
W
W
C
L
G
A
V
L
Y
E
M
L
Y
G
L
P
P
F
Y
S
R
N
----
T
A
E
M
Y
D
N
I
L
N
K
P
L
Q
L
K
P
N
I
T
N
S
A
R
H
L
L
E
G
L
L
Q
K
D
R
T
K
R
L
G
A
K
-
D
-
D
F
M
E
-
I
K
S
H
V
F
F
S
L
I
N
W
D
D
L
I
N
K
K
I
T
P
P
F
N
P
N
V
S
G
------------------------------------------------------------------------------------------
78
PsiBlast_CBE
49.07
32%
-87
- C1 -
3WF5
1
KS6B1_HUMAN
A:
[15-304]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
I
R
P
E
C
F
E
L
L
R
V
L
G
K
G
G
Y
G
K
V
F
Q
V
R
K
VTG
A
N
T
G
K
I
F
A
M
K
V
L
K
K
------------
T
K
A
E
R
N
I
L
-
E
E
-
V
-
K
H
---
P
---
F
I
V
D
L
I
Y
A
F
Q
T
G
G
K
L
Y
L
I
L
E
Y
L
S
G
G
E
L
F
M
Q
L
----
E
R
E
G
I
F
M
E
D
T
A
C
F
Y
L
A
E
I
S
M
A
L
G
H
L
H
-
Q
-
K
G
I
I
Y
R
D
L
K
P
E
N
I
M
L
N
H
Q
G
H
V
K
L
T
D
F
G
L
C
K
E
S
I
H
D
G
T
V
T
H
T
F
C
G
T
I
E
Y
M
A
P
E
I
L
M
-
R
S
G
H
N
R
A
V
D
W
W
S
L
G
A
L
M
Y
D
M
L
T
G
A
P
P
F
T
G
E
N
----
R
K
K
T
I
D
K
I
L
K
C
K
L
N
L
P
P
Y
L
T
Q
E
A
R
D
L
L
K
K
L
L
K
R
N
A
A
S
R
L
G
A
G
-
P
-
G
D
A
G
E
V
Q
A
H
P
F
F
R
H
I
N
W
E
E
L
L
A
R
K
V
E
P
P
F
K
P
L
L
Q
-------------------------------------------------------------------------------------------
98
HHSearch
49.06
38%
-88
- C1 -
3TXO
1
A:
[23-314]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
N
F
E
F
I
R
V
L
G
K
G
S
F
G
K
V
M
L
A
R
V
---
K
E
T
G
D
L
Y
A
V
K
V
L
K
K
D
V
I
L
Q
-
D
D
D
V
E
C
T
M
T
E
K
R
I
L
-
S
L
-
A
R
N
H
---
P
---
F
L
T
Q
L
F
C
C
F
Q
T
P
D
R
L
F
F
V
M
E
F
V
N
G
G
D
L
M
F
H
I
Q
K
----
S
R
R
F
D
E
A
R
A
R
F
Y
A
A
E
I
I
S
A
L
M
F
L
H
-
D
-
K
G
I
I
Y
R
D
L
K
L
D
N
V
L
L
D
H
E
G
H
C
K
L
A
D
F
G
M
C
K
E
G
I
C
---------
G
T
P
D
Y
I
A
P
E
I
L
Q
-
E
M
L
Y
G
P
A
V
D
W
W
A
M
G
V
L
L
Y
E
M
L
C
G
H
A
P
F
E
A
E
N
----
E
D
D
L
F
E
A
I
L
N
D
E
V
V
Y
P
T
W
L
H
E
D
A
T
G
I
L
K
S
F
M
T
K
N
P
T
M
R
L
G
S
L
-
T
Q
G
G
E
H
A
I
L
R
H
P
F
F
K
E
I
D
W
A
Q
L
N
H
R
Q
I
E
P
P
F
R
P
R
I
-----
K
S
R
E
D
V
S
N
F
D
---
P
--
D
F
I
K
E
E
P
V
L
T
P
I
D
E
G
H
L
P
M
I
N
Q
D
E
F
R
N
F
E
Y
V
S
P
--------------------------------------
61
PsiBlast_CBE
48.70
34%
-89
- C1 -
2UZV
1
KAPCA_BOVIN
A:
[27-305]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
Q
F
E
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
---
M
E
T
G
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
K
-
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
A
-
V
-
N
F
---
P
---
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
G
R
----
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
-
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
R
V
---
K
G
R
T
W
T
L
C
G
T
P
E
Y
L
A
P
E
I
I
L
-
S
K
G
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
A
D
----
Q
P
I
Q
I
Y
E
K
I
V
S
G
K
V
R
F
P
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
N
L
-
K
-
D
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
D
Y
E
E
E
---
E
--
I
R
V
S
I
N
E
K
C
G
K
E
F
S
E
F
-------------------------------------------------------
47
PsiBlast_CBE
47.93
35%
-100
- C1 -
3O96
1
AKT1_HUMAN
A:
[156-430]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
K
L
L
G
K
G
T
F
G
K
V
I
L
V
K
E
---
K
A
T
G
R
Y
Y
A
M
K
I
L
K
K
E
V
I
V
A
-----------
N
R
V
L
-
Q
N
-
S
-
R
H
---
P
---
F
L
T
A
L
K
Y
S
F
Q
T
H
D
R
L
C
F
V
M
E
Y
A
N
G
G
E
L
F
F
H
L
----
S
R
E
R
V
F
S
E
D
R
A
R
F
Y
G
A
E
I
V
S
A
L
D
Y
L
H
S
E
-
K
N
V
V
Y
R
D
L
K
L
E
N
L
M
L
D
K
D
G
H
I
K
I
T
D
F
G
L
C
K
E
--------------
P
E
Y
L
A
P
E
V
L
E
-
D
N
D
Y
G
R
A
V
D
W
W
G
L
G
V
V
M
Y
E
M
M
C
G
R
L
P
F
Y
N
Q
----
D
H
E
K
L
F
E
L
I
L
M
E
E
I
R
F
P
R
T
L
G
P
E
A
K
S
L
L
S
G
L
L
K
K
D
P
K
Q
R
L
G
G
G
-
S
-
E
D
A
K
E
I
M
Q
H
R
F
F
A
G
I
V
W
Q
H
V
Y
E
K
K
L
S
P
P
F
K
P
Q
V
--------------------------------------------------------------------------------------------
71
PsiBlast_CBE
47.61
32%
-94
- C1 -
3A60
1
KS6B1_HUMAN
A:
[13-299]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
I
R
P
E
C
F
E
L
L
R
V
L
G
K
G
G
Y
G
K
V
F
Q
V
R
K
V
T
G
A
N
T
G
K
I
F
A
M
K
V
L
K
K
A
M
-----------
K
A
E
R
N
I
L
-
E
E
-
V
-
K
H
---
P
---
F
I
V
D
L
I
Y
A
F
Q
T
G
G
K
L
Y
L
I
L
E
Y
L
S
G
G
E
L
F
M
Q
L
----
E
R
E
G
I
F
M
E
D
T
A
C
F
Y
L
A
E
I
S
M
A
L
G
H
L
H
-
Q
-
K
G
I
I
Y
R
D
L
K
P
E
N
I
M
L
N
H
Q
G
H
V
K
L
T
D
F
G
L
C
K
E
-------------
T
I
E
Y
M
A
P
E
I
L
M
-
R
S
G
H
N
R
A
V
D
W
W
S
L
G
A
L
M
Y
D
M
L
T
G
A
P
P
F
T
G
E
N
----
R
K
K
T
I
D
K
I
L
K
C
K
L
N
L
P
P
Y
L
T
Q
E
A
R
D
L
L
K
K
L
L
K
R
N
A
A
S
R
L
G
A
G
-
P
-
G
D
A
G
E
V
Q
A
H
P
F
F
R
H
I
N
W
E
E
L
L
A
R
K
V
E
P
P
F
K
P
----------------------------------------------------------------------------------------------
70
PsiBlast_CBE
47.16
32%
-91
- C1 -
3A60
1
KS6B1_HUMAN
B:
[13-300]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
I
R
P
E
C
F
E
L
L
R
V
L
G
K
G
G
Y
G
K
V
F
Q
V
R
K
VTG
A
N
T
G
K
I
F
A
M
K
V
L
K
K
--------------------------
K
H
---
P
---
F
I
V
D
L
I
Y
A
F
Q
T
G
G
K
L
Y
L
I
L
E
Y
L
S
G
G
E
L
F
M
Q
L
----
E
R
E
G
I
F
M
E
D
T
A
C
F
Y
L
A
E
I
S
M
A
L
G
H
L
H
-
Q
-
K
G
I
I
Y
R
D
L
K
P
E
N
I
M
L
N
H
Q
G
H
V
K
L
T
D
F
G
L
C
K
E
S
----------
C
G
T
I
E
Y
M
A
P
E
I
L
M
-
R
S
G
H
N
R
A
V
D
W
W
S
L
G
A
L
M
Y
D
M
L
T
G
A
P
P
F
T
G
E
N
----
R
K
K
T
I
D
K
I
L
K
C
K
L
N
L
P
P
Y
L
T
Q
E
A
R
D
L
L
K
K
L
L
K
R
N
A
A
S
R
L
G
A
G
-
P
-
G
D
A
G
E
V
Q
A
H
P
F
F
R
H
I
N
W
E
E
L
L
A
R
K
V
E
P
P
F
K
P
L
---------------------------------------------------------------------------------------------
74
PsiBlast_CBE
45.99
34%
-98
- C1 -
4RLO
4
KS6B1_HUMAN
B:
[7-287]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
E
L
L
R
V
L
G
K
G
G
Y
G
K
V
F
Q
V
R
K
VTG
A
N
T
G
K
I
F
A
M
K
V
L
K
K
--------------------------
K
H
---
P
---
F
I
V
D
L
I
Y
A
F
Q
T
G
G
K
L
Y
L
I
L
E
Y
L
S
G
G
E
L
F
M
Q
L
----
E
R
E
G
I
F
M
E
D
T
A
C
F
Y
L
A
E
I
S
M
A
L
G
H
L
H
-
Q
-
K
G
I
I
Y
R
D
L
K
P
E
N
I
M
L
N
H
Q
G
H
V
K
L
T
D
F
G
L
C
K
E
S
I
-----------
T
I
E
Y
M
A
P
E
I
L
M
-
R
S
G
H
N
R
A
V
D
W
W
S
L
G
A
L
M
Y
D
M
L
T
G
A
P
P
F
T
G
E
N
----
R
K
K
T
I
D
K
I
L
K
C
K
L
N
L
P
P
Y
L
T
Q
E
A
R
D
L
L
K
K
L
L
K
R
N
A
A
S
R
L
G
A
G
-
P
-
G
D
A
G
E
V
Q
A
H
P
F
F
R
H
I
N
W
E
E
L
L
A
R
K
V
E
P
P
F
K
P
L
---------------------------------------------------------------------------------------------
29
PsiBlast_CBE
41.95
48%
24
- C1 -
3NYO
2
GRK6_HUMAN
B:
[5-537]
-----
L
E
N
I
V
A
N
T
V
L
L
K
A
R
E
G
--
G
G
G
N
R
K
G
K
S
K
K
W
R
Q
M
L
Q
F
P
H
I
S
Q
C
--
E
E
L
R
L
S
L
E
R
D
Y
H
S
L
C
E
R
Q
P
I
G
R
L
L
F
R
E
F
-
C
A
T
R
P
E
L
S
R
C
V
A
F
L
----
D
G
V
A
E
Y
E
V
T
P
D
D
K
R
K
-
A
C
-
G
R
Q
L
T
Q
N
F
L
S
H
T
G
P
D
L
I
P
E
V
P
R
Q
L
V
T
NCTQ
R
L
E
Q
G
P
C
---
K
----
D
--
L
F
Q
E
L
T
R
L
T
H
E
Y
L
S
V
A
P
F
A
D
Y
L
D
S
I
Y
F
N
R
F
L
Q
W
K
W
L
E
R
Q
-
P
V
T
K
N
T
F
R
Q
Y
R
V
L
G
K
G
G
F
G
E
V
C
A
C
Q
V
---
R
A
T
G
K
M
Y
A
C
K
K
L
E
K
K
R
I
K
K
-
R
K
G
E
A
M
A
L
N
E
K
Q
I
L
-
E
K
-
V
-
N
S
---
R
---
F
V
V
S
L
A
Y
A
Y
E
T
K
D
A
L
C
L
V
L
T
L
M
N
G
G
D
L
K
F
H
I
Y
H
M
G
Q
A
--
G
F
P
E
A
R
A
V
F
Y
A
A
E
I
C
C
G
L
E
D
L
H
-
R
-
E
R
I
V
Y
R
D
L
K
P
E
N
I
L
L
D
D
H
G
H
I
R
I
S
D
L
G
L
A
V
H
V
P
E
G
Q
T
-
I
K
G
R
V
G
T
V
G
Y
M
A
P
E
V
V
K
-
N
E
R
Y
T
F
S
P
D
W
W
A
L
G
C
L
L
Y
E
M
I
A
G
Q
S
P
F
Q
---
K
K
I
K
R
E
E
V
E
R
L
V
K
E
V
P
E
E
Y
S
E
R
F
S
P
Q
A
R
S
L
C
S
Q
L
L
C
K
D
P
A
E
R
L
G
C
R
-
G
-
G
S
A
R
E
V
K
E
H
P
L
F
K
K
L
N
F
K
R
L
G
A
G
M
L
E
P
P
F
K
P
D
P
Q
A
I
Y
C
K
D
V
L
D
I
E
Q
F
S
---
T
--
V
K
G
V
E
L
E
P
T
D
Q
D
F
Y
Q
K
F
A
T
G
S
V
P
I
P
W
Q
N
E
M
V
E
T
E
C
F
Q
E
L
N
V
F
G
L
D
G
S
V
P
P
D
L
D
W
K
G
Q
P
P
A
P
P
K
K
G
L
L
Q
R
L
F
12
PsiBlast_PDB
41.43
48%
26
- C1 -
3NYO
2
GRK6_HUMAN
A:
[5-537]
-----
L
E
N
I
V
A
N
T
V
L
L
K
A
R
E
G
--
G
G
G
N
R
K
G
K
S
K
K
W
R
Q
M
L
Q
F
P
H
I
S
Q
C
--
E
E
L
R
L
S
L
E
R
D
Y
H
S
L
C
E
R
Q
P
I
G
R
L
L
F
R
E
F
-
C
A
T
R
P
E
L
S
R
C
V
A
F
L
----
D
G
V
A
E
Y
E
V
T
P
D
D
K
R
K
-
A
C
-
G
R
Q
L
T
Q
N
F
L
S
H
T
G
P
D
L
I
P
E
V
P
R
Q
L
V
T
N
C
T
Q
R
L
E
Q
G
P
C
---
K
----
D
--
L
F
Q
E
L
T
R
L
T
H
E
Y
L
S
V
A
P
F
A
D
Y
L
D
S
I
Y
F
N
R
F
L
Q
W
K
W
L
E
R
Q
-
P
V
T
K
N
T
F
R
Q
Y
R
V
L
G
K
G
G
F
G
E
V
C
A
C
Q
V
---
R
A
T
G
K
M
Y
A
C
K
K
L
E
K
K
R
I
K
K
-
R
K
G
E
A
M
A
L
N
E
K
Q
I
L
-
E
K
-
V
-
N
S
---
R
---
F
V
V
S
L
A
Y
A
Y
E
T
K
D
A
L
C
L
V
L
T
L
M
N
G
G
D
L
K
F
H
I
Y
H
M
G
Q
A
--
G
F
P
E
A
R
A
V
F
Y
A
A
E
I
C
C
G
L
E
D
L
H
-
R
-
E
R
I
V
Y
R
D
L
K
P
E
N
I
L
L
D
D
H
G
H
I
R
I
S
D
L
G
L
A
V
H
V
P
E
G
Q
T
-
I
K
G
R
V
G
T
V
G
Y
M
A
P
E
V
V
K
-
N
E
R
Y
T
F
S
P
D
W
W
A
L
G
C
L
L
Y
E
M
I
A
G
Q
S
P
F
Q
---
K
K
I
K
R
E
E
V
E
R
L
V
K
E
V
P
E
E
Y
S
E
R
F
S
P
Q
A
R
S
L
C
S
Q
L
L
C
K
D
P
A
E
R
L
G
C
R
-
G
-
G
S
A
R
E
V
K
E
H
P
L
F
K
K
L
N
F
K
R
L
G
A
G
M
L
E
P
P
F
K
P
D
P
Q
A
I
Y
C
K
D
V
L
D
I
E
Q
F
S
---
T
--
V
K
G
V
E
L
E
P
T
D
Q
D
F
Y
Q
K
F
A
T
G
S
V
P
I
P
W
Q
N
E
M
V
E
T
E
C
F
Q
E
L
N
V
F
G
L
D
G
S
V
P
P
D
L
D
W
K
G
Q
P
P
A
P
P
K
K
G
L
L
Q
R
L
F
30
PsiBlast_CBE
40.60
48%
29
- C1 -
3NYN
2
GRK6_HUMAN
B:
[5-537]
-----
L
E
N
I
V
A
N
T
V
L
L
K
A
R
E
G
--
G
G
G
N
R
K
G
K
S
K
K
W
R
Q
M
L
Q
F
P
H
I
S
Q
C
--
E
E
L
R
L
S
L
E
R
D
Y
H
S
L
C
E
R
Q
P
I
G
R
L
L
F
R
E
F
-
C
A
T
R
P
E
L
S
R
C
V
A
F
L
----
D
G
V
A
E
Y
E
V
T
P
D
D
K
R
K
-
A
C
-
G
R
Q
L
T
Q
N
F
L
S
H
T
G
P
D
L
I
P
E
V
P
R
Q
L
V
T
NCTQ
R
L
E
Q
G
P
C
---
K
----
D
--
L
F
Q
E
L
T
R
L
T
H
E
Y
L
S
V
A
P
F
A
D
Y
L
D
S
I
Y
F
N
R
F
L
Q
W
K
W
L
E
R
Q
-
P
V
T
K
N
T
F
R
Q
Y
R
V
L
G
K
G
G
F
G
E
V
C
A
C
Q
V
---
R
A
T
G
K
M
Y
A
C
K
K
L
E
K
K
R
I
K
K
-
R
K
G
E
A
M
A
L
N
E
K
Q
I
L
-
E
K
-
V
-
N
S
---
R
---
F
V
V
S
L
A
Y
A
Y
E
T
K
D
A
L
C
L
V
L
T
L
M
N
G
G
D
L
K
F
H
I
Y
H
M
G
Q
A
--
G
F
P
E
A
R
A
V
F
Y
A
A
E
I
C
C
G
L
E
D
L
H
-
R
-
E
R
I
V
Y
R
D
L
K
P
E
N
I
L
L
D
D
H
G
H
I
R
I
S
D
L
G
L
A
V
H
V
P
E
G
Q
T
-
I
K
G
R
V
G
T
V
G
Y
M
A
P
E
V
V
K
-
N
E
R
Y
T
F
S
P
D
W
W
A
L
G
C
L
L
Y
E
M
I
A
G
Q
S
P
F
Q
---
K
K
I
K
R
E
E
V
E
R
L
V
K
E
V
P
E
E
Y
S
E
R
F
S
P
Q
A
R
S
L
C
S
Q
L
L
C
K
D
P
A
E
R
L
G
C
R
-
G
-
G
S
A
R
E
V
K
E
H
P
L
F
K
K
L
N
F
K
R
L
G
A
G
M
L
E
P
P
F
K
P
D
P
Q
A
I
Y
C
K
D
V
L
D
I
E
Q
F
S
---
T
--
V
K
G
V
E
L
E
P
T
D
Q
D
F
Y
Q
K
F
A
T
G
S
V
P
I
P
W
Q
N
E
M
V
E
T
E
C
F
Q
E
L
N
V
F
G
L
D
G
S
V
P
P
D
L
D
W
K
G
Q
P
P
A
P
P
K
K
G
L
L
Q
R
L
F