@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : Wbm0118: (2015-11-28 )
MRILNYTIINLVISKSLLLNMNGIKKGIIHIIGIGGIGMSAIAEILHNSNYKVQGSDAQSNNNVDRLQKLGIEIYIGHNANNIKQAQVVVYSSAIKSDNVELVAARNNNKTILHRSGILAEIMKDKYVIAVSGSSGKTTTTAMIASIFDHSNTDATVIVGGILNSYQNNSKLGKSDILLIEADESDETMLKIPANIAVITSINNDHIDHYGTFDNIKNAFSQFINSADFAILPDSVGINDSESVSIKFGFEGVYPFVIQSPFVVPVHDIGIKKKKSASCSIKASNVKANNIRQHNNSIEFDVLIDGCSIDRSHWIPASCTETTAVLPLSSTQITSLRSRIIKNVVLSNAIGMHKVSNALAAISVAIKLGINDVDIKKGLLEFKGVARRFSLVADIKDVKLIEDYAHHPSEIQATLTAARSITKGKIIGIIEPFRFARIRNFFDEFIRIFMMFDYVILVPVHPPEDKPILGCRIDDIQEALISNGFNNVKIMNDALLISNFISDSTNSGDIVLFIGAGINVARLARETVVFMSGVEI
Atome Classification :
(20 SA)
--------.........10........20-...-----.....30........40--........50........60--...-..-.--...70....-.------------..--.80-..--..--....90.......-----.--100.......-110.......120..-.--.....130......-.140....-...150.......-------------160.-.---------.------------------------..-------------------------------.----------.-----------.---170----.----------.---------.......180.-..-.--.-.-------.190-----...--......200.......210-....-----....220.....----.---.230--..-.....---240--.---.---------...------....250.......260...-....270.......280.......290.......300.......310.......320.......330.......340.......350.......360.....--.---.---370-........380.......390..----.....400.......410.......420-..-.....430.......440..-.....450........460..--.....470.......480.--......490.......500..---.-----------....510.......520.......530....
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
--------
M
R
I
L
N
Y
T
I
I
N
L
V
I
S
K
S
L
L
LNM-NGI-----KKG
I
I
H
I
I
G
IGGI
G
M
S
A
--
I
A
E
I
L
HNSN
Y
K
V
QGSDAQS---NN
N
-
V
D
-
R
--
L
Q
KL
G
I
E
I
Y
-
I
------------GH--NAN-N
I
--
K
Q
--
A
Q
V
V
V
Y
S
SAIKSD-----
N
--
V
E
L
V
A
ARNN
N
-
K
T
I
L
HRS
G
I
L
A
E
-
I
M-K--D
K
Y
V
I
A
V
SGSSG
K
T
-
T
T
T
A
M
I
A
S
-
I
FDHSNT
D
A
T
V
I
V
-------------
G
G
-
I
-
L
---------
N
------------------------
S
Y-------------------------------Q----------N-----------N---S------K----------L---------GKS
D
I
L
L
I
EAD-ES-D--E-
T
-------
M
L
-------KIP--A
N
I
A
V
I
T
SINNDHIDHY-G-
T
F
D
N
-----
I
K
N
A
F
S
Q
F
I
NSA----D---
F
A
IL--PD-SVGIN---D----S---
E
---------
S
V
S
------
I
K
F
GFEGV
Y
P
F
V
IQS
P
F
V
V
P
-
V
HDIGIKKKKSAS
C
S
I
K
ASNVKANNIRQHNNS
I
E
F
D
V
L
I
DGCSIDRSHWIPASCTE
T
T
A
V
L
PLS
S
T
Q
I
T
S
L
R
S
R
I
I
K
N
V
V
L
SNAI
G
M
H
K
V
S
N
A
L
A
A
I
S
V
A
I
K
--L---G---I
N
--
D
V
D
I
K
K
G
L
L
E
F
K
G
V
A
R
R
F
S
L
V
AD----
I
K
D
V
K
L
I
E
D
YAH
H
P
S
E
I
Q
A
T
L
T
A
A
RSIT-KG-
K
I
I
G
I
IE
P
F
R
F
A
R
I
R
N
F
F
D
E
-
F
I
R
I
F
M
-
M
F
D
Y
V
I
L
V
PVHPPE--DK
P
I
L
G
C
R
I
D
D
I
Q
E
A
L
I
SN--GFN
N
V
K
I
M
N
D
A
L
L
I
S
N
F
ISDS---T-----------NSG
D
I
V
L
F
IGAG
I
N
V
A
R
L
A
R
E
T
V
V
F
MSGVEI
26
HHSearch
96.65
35%
-104
- C1 -
1P3D
4
MURC_HAEIN
A:
[16-473]
--------------------------------
R
-----
R
V
Q
Q
I
H
F
I
G
I
G
G
A
G
M
S
G
--
I
A
E
I
L
L
N
E
G
Y
Q
I
S
G
S
D
I
A
D
---
G
V
V
-
T
Q
-
R
--
L
A
Q
A
G
A
K
I
Y
-
I
------------
G
H
--
A
E
E
-
H
I
--
E
G
--
A
S
V
V
V
V
S
S
A
I
K
D
D
-----
N
--
P
E
L
V
T
S
K
Q
K
R
-
I
P
V
I
Q
R
A
Q
M
L
A
E
-
I
M
-
R
--
F
R
H
G
I
A
V
A
G
T
H
G
K
T
-
T
T
T
A
M
I
S
M
-
I
Y
T
Q
A
K
L
D
P
T
F
V
N
-------------
G
G
-
L
-
V
---------
K
------------------------
S
A
-------------------------------
G
----------
K
-----------
N
---
A
------
H
----------
L
---------
G
A
S
R
Y
L
I
A
E
A
D
-
E
S
-
D
--
A
-
S
-------
F
L
-------
H
L
Q
--
P
M
V
S
V
V
T
N
M
E
P
D
H
M
D
T
Y
-
E
G
D
F
E
K
-----
M
K
A
T
Y
V
K
F
L
H
N
L
----
P
FY
G
L
A
V
M
C
A
D
D
-
P
V
L
M
E
L
V
P
K
----
V
---
G
---------
R
Q
V
------
I
T
Y
G
F
S
E
-------------------------------
Q
A
D
Y
R
I
E
D
Y
E
Q
T
G
F
Q
G
H
Y
T
V
I
C
P
N
N
---------------------------------
E
R
I
N
V
L
L
N
V
P
G
K
H
N
A
L
N
A
T
A
A
L
A
V
A
K
E
--
E
---
G
---
I
A
--
N
E
A
I
L
E
A
L
A
D
F
Q
G
A
G
R
R
F
D
Q
L
G
E
F
I
R
P
N
G
K
V
R
L
V
D
D
Y
G
H
H
P
T
E
V
G
V
T
I
K
A
A
R
E
G
W
G
D
K
-
R
I
V
M
I
F
Q
P
H
R
Y
S
R
T
R
D
L
F
D
D
-
F
V
Q
V
L
S
-
Q
V
D
A
L
I
M
L
D
V
Y
A
A
G
--
E
A
P
I
V
G
A
D
S
K
S
L
C
R
S
I
R
N
L
--
G
K
V
D
P
I
L
V
S
D
T
S
Q
L
G
D
V
L
D
Q
I
---
I
-----------
Q
D
G
D
L
I
L
A
Q
G
A
G
S
-
V
S
K
I
S
R
G
L
A
E
S
W
-----
28
HHSearch
72.62
22%
-92
* C1 *
3LK7
3
MURD_STRA5
A:
[4-432]
----------------------------
I
-
T
T
F
-----
E
N
K
K
V
L
V
L
G
L
A
R
S
G
E
-
A
--
A
A
R
L
L
A
K
L
G
A
I
V
T
V
N
D
G
K
P
FDE
N
P
T
-
A
Q
-
S
--
L
L
E
E
G
I
K
V
V
-
C
------------
G
S
--
H
P
L
E
L
L
D
-
E
D
--
F
C
Y
M
I
K
N
P
G
I
P
Y
N
-----
N
--
P
M
V
K
K
A
L
E
K
Q
-
I
P
V
L
T
E
V
E
L
A
Y
L
-
V
--
S
--
E
S
Q
L
I
G
I
T
G
S
N
G
K
T
-
T
T
T
T
M
I
A
E
-
V
L
N
A
G
G
Q
-
R
G
L
L
A
-------------
G
N
-
I
-----------
G
------------------------
F
P
-------------------------------
A
----------
S
-----------
E
V
V
-
Q
------
A
----------
A
---------
N
D
K
D
T
L
V
M
E
L
S
-
S
F
-
Q
--
L
M
G
-------
V
K
-------
E
F
R
--
P
H
I
A
V
I
T
N
L
M
P
T
H
L
D
Y
H
-
G
-
S
F
E
D
-----
Y
V
A
A
K
W
N
I
Q
N
Q
M
SSS-
D
---
F
L
V
L
N
F
N
Q
-
G
I
S
K
E
L
A
K
T
----
T
---
K
---------
A
T
I
------
V
P
F
S
T
T
E
K
------------------------------
V
D
G
A
Y
V
Q
D
---------
K
Q
L
F
Y
K
G
E
--------------------------------
N
I
M
S
V
D
D
I
G
V
P
G
S
H
N
V
E
N
A
L
A
T
I
A
V
A
K
L
--
A
---
G
---
I
S
--
N
Q
V
I
R
E
T
L
S
N
F
G
G
V
K
H
R
L
Q
S
L
G
K
----
V
H
G
I
S
F
Y
N
D
S
K
--
S
T
N
I
L
A
T
Q
K
A
L
S
G
F
D
-
N
T
-
K
V
I
L
I
A
G
G
L
--
D
R
G
N
E
-
F
D
E
-
L
I
P
D
I
T
-
G
L
K
H
M
V
V
L
G
E
-------------
S
A
S
R
V
K
R
A
A
Q
K
A
--
G
V
T
-
Y
S
D
A
L
D
V
R
D
A
V
H
K
A
Y
E
V
---
A
-----------
Q
Q
G
D
V
I
L
L
S
P
A
N
A
-
S
W
D
M
Y
K
N
F
E
V
R
G
D
E
F
I
D
31
HHSearch
72.31
28%
-90
- C1 -
3EAG
2
?
A:
[3-326]
--------------------------------------
A
M
K
H
I
H
I
I
G
I
G
G
T
F
M
G
G
--
L
A
A
I
A
K
E
A
G
F
E
V
S
G
C
D
A
K
M
---
Y
P
P
M
S
T
-
Q
--
L
E
A
L
G
I
D
V
Y
-
E
------------
G
F
--
D
A
A
-
Q
L
DE
F
K
--
A
D
V
Y
V
I
G
N
V
A
K
R
G
-----
M
--
D
V
V
E
A
I
L
N
L
G
-
L
P
Y
I
S
G
P
Q
W
L
S
E
-
N
V
-
L
H-
H
H
W
V
L
G
V
A
G
T
H
G
K
T
-
T
T
A
S
M
L
A
W
-
V
L
E
Y
A
G
L
A
P
G
F
L
I
-------------
G
G
-
V
-
P
---------
E
------------------------
N
F
GVS----------------------------
A
----------
R
LPQTP------
R
Q--
D
------
P
----------
N
---------
S
Q
S
P
F
F
V
I
E
A
D
-
E
Y
-
D
--
T
-
A
FFDKRSK
F
V
-------
H
Y
R
--
P
R
T
A
V
L
N
N
L
E
F
D
H
A
D
I
F
-
A
-
D
L
G
A
-----
I
Q
T
Q
F
H
Y
L
V
R
T
V
PSE-
G
---
L
I
V
C
N
G
R
Q
-
Q
S
L
Q
D
T
L
D
K
G---
C
---
W
---------
T
P
V
------
E
K
F
G
T
E
H
---------------------------------
G
W
Q
A
G
E
A
N
A
---
D
G
S
F
D
V
L
L
D
G
K
---------------------------------
T
A
G
R
V
K
W
D
L
M
G
R
H
N
R
M
N
A
L
A
V
I
A
A
A
R
H
--
V
---
G
---
V
D
--
I
Q
T
A
C
E
A
L
G
A
F
K
N
V
K
R
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
8
PsiBlast_PDB
66.43
21%
-84
- C1 -
3EAG
2
?
A:
[20-326]
---------------------------------------------------------
L
A
A
I
A
K
E
A
G
F
E
V
S
G
C
D
A
K
M
---
Y
P
P
-
M
S
T
Q
--
L
E
A
L
G
I
D
V
Y
-
E
------------
G
F
--
D
A
A
-
Q
L
--
D
E
FK
A
D
V
Y
V
I
G
N
V
A
K
R
G
-----
M
--
D
V
V
E
A
I
L
N
L
G
-
L
P
Y
I
S
G
P
Q
W
L
S
E
N
V
L
-
H
--
H
H
W
V
L
G
V
A
G
T
H
G
K
T
-
T
T
A
S
M
L
A
W
-
V
L
E
Y
A
G
L
A
P
G
F
L
I
-------------
G
G
-
V
-
P
---------
E
------------------------
N
F
-------------------------------
G
----------
V
-----------
S
---
A
------
R
----------
L
PQTPRQDPN
S
Q
S
P
F
F
V
I
E
A
D
-
E
Y
-
D
--
T
-
A
-------
F
F
DKRSKFV
H
Y
R
--
P
R
T
A
V
L
N
N
L
E
F
D
H
A
D
I
F
-
A
-
D
L
G
A
-----
I
Q
T
Q
F
H
Y
L
V
R
T
------------
V
--
P
---------------
S
---
E
---------
G
L
I
------
V
C
N
G
R
Q
Q
S
L
Q
D
T
L
D
K
G
C
W
T
P
-
V
E
K
F
G
T
E
H
G
W
Q
A
G
--------------
E
A
N
A
D
G
S
F
D
V
L
L
D
G
K
T
A
G
R
V
K
W
---------------------------------
D
L
M
G
R
H
N
R
M
N
A
L
A
V
I
A
A
A
R
H
--
V
---
G
---
V
D
--
I
Q
T
A
C
E
A
L
G
A
F
K
N
V
K
R
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
33
HHSearch
65.73
21%
-98
- C1 -
3NRS
7
?
A:
[51-426]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
P
K
I
F
T
V
A
G
T
N
G
K
G
-
T
T
C
C
T
L
E
A
-
I
L
L
A
A
G
L
R
V
G
V
Y
S
-------------
S
P
H
L
-
L
RYTERVRIQ
G
------------------------
Q
E
L
S
E
A
E
H
S
H
S
F
A
Q
I
E
A
G
R
GD
I
S
L
T
Y
F
E
F
G
T
L
S
A
----------
L
-----------
Q
L
--
F
------
K
----------
Q
---------
A
K
L
D
V
V
I
L
E
V
G
-
L
G
-
G
RL
D
-
A
-------
T
N
-------
I
V
D
--
S
D
V
A
A
I
T
S
I
A
L
D
H
T
D
W
L
-
G
Y
D
R
E
S
-----
I
G
R
E
K
A
G
V
F
R
G
G
----
K
---
P
A
V
V
GE
P
D
M
P
Q
S
I
A
---
D
V
---
A
A
E
L
G
---------
A
Q
L
Y
R
R
DVA
W
K
F
S
Q
----------------------------------------------
N
G
W
H
W
Q
C
---
G
----------------------------------
E
R
Q
L
T
G
L
P
V
P
N
-
V
P
L
A
N
A
A
T
A
L
A
V
L
H
Y
S
E
L
---
P
---
L
S
--
D
E
A
I
R
Q
G
L
Q
A
A
-
S
L
P
G
R
F
Q
V
V
S
E
------
Q
P
L
L
I
L
D
V
A
H
N
P
H
A
A
R
Y
L
V
N
R
L
A
Q
V
I
--
G
-
K
V
R
A
V
V
G
M
L
S
D
---
K
D
-
I
A
G
-
T
L
A
C
L
S
E
R
V
D
E
W
Y
C
A
P
L
E
G
P
-------
R
G
A
S
A
G
Q
L
A
E
H
L
V
S
-------
A
R
Q
F
S
D
V
E
T
A
W
R
Q
A
M
Q
D
---
A
-----------
D
T
Q
D
V
V
I
V
C
G
S
F
H
T
V
A
H
V
M
A
A
L
H
L
-------
1
PsiBlast_PDB
64.85
45%
-98
- C1 -
1GQY
2
MURC_HAEIN
A:
[21-222]
------------------------------------------
I
H
F
I
G
I
G
G
A
G
M
S
G
--
I
A
E
I
L
L
N
E
G
Y
Q
I
S
G
S
D
I
A
D
---
G
V
V
-
T
Q
-
R
--
L
A
Q
A
G
A
K
I
Y
-
I
------------
G
H
--
A
E
E
-
H
I
--
E
G
--
A
S
V
V
V
V
S
S
A
I
K
D
D
-----
N
--
P
E
L
V
T
S
K
Q
K
R
-
I
P
V
I
Q
R
A
Q
M
L
A
E
-
I
M
-
R
--
F
R
H
G
I
A
V
A
G
T
H
G
K
T
-
T
T
T
A
M
I
S
M
-
I
Y
T
Q
A
K
L
D
P
T
F
V
N
-------------
G
G
-
L
-
V
---------
K
------------------------
S
A
-------------------------------
G
----------
K
-----------
N
---
A
------
H
----------
L
---------
G
A
S
R
Y
L
I
A
E
A
D
-
E
S
-
D
--
A
-
S
-------
F
L
-------
H
L
Q
--
P
M
V
S
V
V
T
N
M
E
P
D
--------
D
F
E
K
-----
M
K
A
T
Y
V
K
F
L
H
N
L
----
P
---
F
Y
G
L
--
A
V
-
M
C
A
D
D
---
P
----
V
---
L
---------
M
E
L
------
V
P
K
V
G
R
Q
V
I
T
Y
G
F
S
E
Q
A
D
Y
R
-
I
E
D
Y
E
Q
T
G
F
Q
G
H
Y
T
V
I
C
P
N
N
E
R
I
N
V
L
L
N
V
P
G
K
H
N
A
L
N
A
T
A
A
L
A
V
A
K
E
E
G
I
A
N
E
A
I
L
E
A
L
A
D
F
Q
G
A
G
R
R
F
D
Q
L
G
E
F
I
R
P
N
G
K
V
R
L
V
D
D
Y
G
H
H
P
T
E
V
G
V
T
I
K
A
A
--
R
---
E
---
G
W
--
G
D
K
R
I
V
M
I
F
Q
P
H
R
Y
S
R
T
R
D
L
F
D
D
----
F
V
Q
V
L
S
Q
V
D
A
L
I
M
L
D
V
Y
A
A
G
E
A
P
I
V
G
A
D
-
S
K
-
S
L
C
R
S
I
R
N
L
G
K
V
D
P
I
L
V
S
D
T
-
S
Q
L
G
D
V
-
L
D
Q
I
I
Q
D
G
D
L
I
L
A
Q
--
G
A
G
S
V
S
K
I
S
R
G
L
A
E
S
W
K
N
----------------------------------------------------------------------
21
PsiBlast_CBE
64.65
45%
-103
- C1 -
1GQY
2
MURC_HAEIN
B:
[21-222]
------------------------------------------
I
H
F
I
G
I
G
G
A
G
M
S
G
--
I
A
E
I
L
L
N
E
G
Y
Q
I
S
G
S
D
I
A
D
---
G
V
V
-
T
Q
-
R
--
L
A
Q
A
G
A
K
I
Y
-
I
------------
G
H
--
A
E
E
-
H
I
--
E
G
--
A
S
V
V
V
V
S
S
A
I
K
D
D
-----
N
--
P
E
L
V
T
S
K
Q
K
R
-
I
P
V
I
Q
R
A
Q
M
L
A
E
-
I
M
-
R
--
F
R
H
G
I
A
V
A
G
T
H
G
K
T
-
T
T
T
A
M
I
S
M
-
I
Y
T
Q
A
K
L
D
P
T
F
V
N
-------------
G
G
-
L
-
V
---------
K
------------------------
S
A
-------------------------------
G
----------
K
-----------
N
---
A
------
H
----------
L
---------
G
A
S
R
Y
L
I
A
E
A
D
-
E
S
-
D
--
A
-
S
-------
F
L
-------
H
L
Q
--
P
M
V
S
V
V
T
N
M
E
P
D
H
M
D
T
Y
E
G
-
D
F
E
K
-----
M
K
A
T
Y
V
K
F
L
H
N
L
----
P
---
F
Y
G
L
--
A
V
-
M
C
A
D
D
---
P
----
V
---
L
---------
M
E
L
------
V
P
K
V
G
R
Q
V
I
T
Y
G
F
S
E
Q
A
D
Y
R
-
I
E
D
Y
E
Q
T
G
F
Q
G
H
Y
T
V
I
C
P
N
N
E
R
I
N
V
L
L
N
V
P
G
K
H
N
A
L
N
A
T
A
A
L
A
V
A
K
E
E
G
I
A
N
E
A
I
L
E
A
L
A
D
F
Q
G
A
G
R
R
F
D
Q
L
G
E
F
I
R
P
N
G
K
V
R
L
V
D
D
Y
G
H
H
P
T
E
V
G
V
T
I
K
A
A
--
R
---
E
---
G
W
--
G
D
K
R
I
V
M
I
F
Q
P
H
R
Y
S
R
T
R
D
L
F
D
D
----
F
V
Q
V
L
S
Q
V
D
A
L
I
M
L
D
V
Y
A
A
G
E
A
P
I
V
G
A
D
-
S
K
-
S
L
C
R
S
I
R
N
L
G
K
V
D
P
I
L
V
S
D
T
-
S
Q
L
G
D
V
-
L
D
Q
I
I
Q
D
G
D
L
I
L
A
Q
--
G
A
G
S
V
S
K
I
S
R
G
L
A
E
S
W
K
-----------------------------------------------------------------------
35
HHSearch
63.57
18%
-89
- C1 -
1O5Z
8
?
A:
[52-422]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
K
T
I
H
I
G
G
T
N
G
K
G
-
S
V
A
N
M
V
S
N
-
I
L
V
S
Q
G
Y
R
V
G
S
Y
Y
S
PHLSTFRERIRL
N
E
-
E
Y
I
---------
S
E
E
D
V
V
K
I
Y
E
T
M
E
P
I
L
N
E
L
D
KEEIF
S
P
-------------------------------
S
F
F
E
V
V
T
A
M
A
F
L
-----------
Y
---
F
------
A
----------
E
---------
K
N
V
D
I
A
V
L
E
V
G
-
L
G
G
R
L-
D
-
A
-------
T
N
-------
V
V
F
--
P
L
C
S
T
I
V
T
V
D
R
--------Y
T
I
E
Q
-----
I
A
W
E
K
S
G
I
I
K
E
R
----
V
---
P
L
V
T
G-
E
R
K
R
E
A
L
K
V
M
E
D
V
---
A
---
R
K
--------
K
S
S
------
R
M
Y
V
I
D
K
-------------------------------
D
F
S
V
K
V
K
S
L
K
--
L
H
E
N
R
F
D
Y
C
G
E
N
----------------------------------
T
F
E
D
L
V
L
T
M
N
G
P
H
Q
I
E
N
A
G
V
A
L
K
T
L
E
A
--
T
---
G
---
L
P
LS
E
K
A
I
R
E
G
L
K
N
A
K
N
-
L
G
R
F
E
I
L
E
K
-----
N
G
K
M
Y
I
L
D
G
A
H
N
P
H
G
A
E
S
L
V
R
S
L
K
L
Y
F
N
G
E
-
P
L
S
L
V
I
G
I
L
D
D
---
K
N
-
R
E
D
-
I
L
R
K
Y
T
G
I
F
E
R
V
I
V
T
R
V
P
S
P
R
-------
M
K
D
M
N
S
L
V
D
M
A
K
K
F
---
F
K
N
V
E
V
I
E
D
P
L
E
A
I
E
--------------------
S
T
E
R
A
T
V
V
T
G
S
L
F
L
V
G
Y
V
R
E
F
L
T
T
G
K
I
N
E
E
W
22
PsiBlast_CBE
62.72
40%
-94
- C1 -
4HV4
1
MURC_YERPE
B:
[18-226]
---------------------------
E
M
-
R
R
V
-----
R
H
--
I
H
F
V
G
I
G
G
A
G
M
G
G
--
I
A
E
V
L
A
N
E
G
Y
Q
I
S
G
S
D
L
A
P
---
N
S
V
-
T
Q
-
H
--
L
T
A
L
G
A
Q
I
Y
-
F
------------
H
H
--
R
P
E
-
N
V
--
L
D
--
A
S
V
V
V
V
S
T
A
I
S
A
D
-----
N
--
P
E
I
V
A
A
R
E
A
R
-
I
P
V
I
R
R
A
E
M
L
A
E
-
L
M
-
R
--
Y
R
H
G
I
A
V
A
G
T
H
G
K
T
-
T
T
T
A
M
L
S
S
-
I
Y
A
E
A
G
L
D
P
T
F
V
N
-------------
G
G
-
L
-
V
---------
K
------------------------
A
A
-------------------------------
G
----------
T
-----------
H
---
A
------
R
----------
L
---------
G
S
S
R
Y
L
I
A
E
A
D
-
E
S
-
D
--
A
-
S
-------
F
L
-------
H
L
Q
--
P
M
V
A
I
V
T
N
I
E
A
D
--------
D
F
E
N
-----
L
K
Q
T
F
I
N
F
L
H
N
L
----
P
---
F
Y
G
R
--
A
V
-
M
C
I
D
D
---
P
----
V
---
V
---------
R
E
L
------
L
P
R
V
G
R
H
I
T
T
Y
G
F
S
D
D
A
D
V
Q
-
I
A
S
Y
R
Q
E
G
P
Q
G
H
F
T
L
R
R
Q
D
K
P
L
I
E
V
T
L
N
A
P
G
R
H
N
A
L
N
A
A
A
A
V
A
V
A
T
E
E
G
I
E
D
E
D
I
L
R
A
L
V
G
F
Q
G
T
G
R
R
F
D
F
L
G
N
F
P
L
A
P
V
N
G
K
E
G
S
A
M
L
V
D
D
Y
G
H
H
P
T
E
V
D
A
--
T
---
I
---
K
A
--
A
R
A
G
W
P
D
K
R
I
V
M
L
F
Q
P
H
R
Y
T
R
T
R
----
D
L
Y
D
D
F
A
N
V
L
S
Q
V
D
V
L
L
M
L
D
V
Y
A
A
G
E
P
P
-
I
P
-
G
A
D
S
R
A
L
C
R
T
I
R
N
R
G
K
L
D
P
I
-
L
V
P
D
S
E
-
S
A
P
E
M
L
A
Q
I
L
N
G
E
D
--
L
I
L
V
Q
G
A
G
N
I
G
K
I
A
R
K
L
A
E
--
H
K
L
Q
P
Q
-------------------------------------------------------------
3
PsiBlast_PDB
62.29
43%
-94
- C1 -
1P31
2
MURC_HAEIN
A:
[21-222]
------------------------------------------
I
H
F
I
G
I
G
G
A
G
M
S
G
--
I
A
E
I
L
L
N
E
G
Y
Q
I
S
G
S
D
I
A
D
---
G
V
V
-
T
Q
-
R
--
L
A
Q
A
G
A
K
I
Y
-
I
------------
G
H
--
A
E
E
-
H
I
--
E
G
--
A
S
V
V
V
V
S
S
A
I
K
D
D
-----
N
--
P
E
L
V
T
S
K
Q
K
R
-
I
P
V
I
Q
R
A
Q
M
L
A
E
-
I
M
-
R
--
F
R
H
G
I
A
V
A
G
T
H
G
K
T
-
T
T
T
A
M
I
S
M
-
I
Y
T
Q
A
K
L
D
P
T
F
V
N
-------------
G
G
-
L
-
V
---------
K
------------------------
S
A
-------------------------------
G
----------
K
-----------
N
---
A
------
H
----------
L
---------
G
A
S
R
Y
L
I
A
E
A
D
-
E
S
-
D
--
A
-
S
-------
F
L
-------
H
L
Q
--
P
M
V
S
V
V
T
N
M
E
P
D
H
M
D
T
Y
E
G
-
D
F
E
K
-----
M
K
A
T
Y
V
K
F
L
H
N
L
----
P
---
F
Y
G
L
--
A
V
-
M
C
A
D
D
---
P
----
V
---
L
---------
M
E
L
------
V
P
K
V
G
R
Q
V
I
T
Y
G
F
S
E
Q
A
D
Y
R
-
I
E
D
Y
E
Q
T
G
F
Q
G
H
Y
T
V
I
C
P
N
N
E
R
I
N
V
L
L
N
V
P
G
K
H
N
A
L
N
A
T
A
A
L
A
V
A
K
E
E
G
I
A
N
E
A
I
L
E
A
L
A
D
F
Q
G
A
G
R
R
F
D
Q
L
G
E
F
I
R
P
N
G
K
V
R
L
V
D
D
Y
G
H
H
P
T
E
V
G
V
T
I
K
A
A
--
R
---
E
---
G
W
--
G
D
K
R
I
V
M
I
F
Q
P
H
R
Y
S
R
T
R
D
L
F
D
D
----
F
V
Q
V
L
S
Q
V
D
A
L
I
M
L
D
V
Y
A
A
G
E
A
P
I
V
G
A
D
-
S
K
-
S
L
C
R
S
I
R
N
L
G
K
V
D
P
I
L
V
S
D
T
-
S
Q
L
G
D
V
-
L
D
Q
I
I
Q
D
G
D
L
I
L
A
Q
--
G
A
G
S
V
S
K
I
S
R
G
L
A
E
S
W
K
-----------------------------------------------------------------------
2
PsiBlast_PDB
62.03
40%
-97
- C1 -
4HV4
1
MURC_YERPE
A:
[22-226]
--------------------------------
V
-----
R
H
--
I
H
F
V
G
I
G
G
A
G
M
G
G
--
I
A
E
V
L
A
N
E
G
Y
Q
I
S
G
S
D
L
A
P
---
N
S
V
-
T
Q
-
H
--
L
T
A
L
G
A
Q
I
Y
-
F
------------
H
H
--
R
P
E
-
N
V
--
L
D
--
A
S
V
V
V
V
S
T
A
I
S
A
D
-----
N
--
P
E
I
V
A
A
R
E
A
R
-
I
P
V
I
R
R
A
E
M
L
A
E
-
L
M
-
R
--
Y
R
H
G
I
A
V
A
G
T
H
G
K
T
-
T
T
T
A
M
L
S
S
-
I
Y
A
E
A
G
L
D
P
T
F
V
N
-------------
G
G
-
L
-
V
---------
K
------------------------
A
A
-------------------------------
G
----------
T
-----------
H
---
A
------
R
----------
L
---------
G
S
S
R
Y
L
I
A
E
A
D
-
E
S
-
D
--
A
-
S
-------
F
L
-------
H
L
Q
--
P
M
V
A
I
V
T
N
I
E
A
D
H
M
D
T
Y
Q
G
-
D
F
E
N
-----
L
K
Q
T
F
I
N
F
L
H
N
L
----
P
---
F
Y
G
R
--
A
V
-
M
C
I
D
D
---
P
----
V
---
V
---------
R
E
L
------
L
P
R
V
G
R
H
I
T
T
Y
G
F
S
D
D
A
D
V
Q
-
I
A
S
Y
R
Q
E
G
P
Q
G
H
F
T
L
R
R
Q
D
K
P
L
I
E
V
T
L
N
A
P
G
R
H
N
A
L
N
A
A
A
A
V
A
V
A
T
E
E
G
I
E
D
E
D
I
L
R
A
L
V
G
F
Q
G
T
G
R
R
F
D
F
L
G
N
F
P
L
A
P
V
N
G
K
E
G
S
A
M
L
V
D
D
Y
G
H
H
P
T
E
V
D
A
--
T
---
I
---
K
A
--
A
R
A
G
W
P
D
K
R
I
V
M
L
F
Q
P
H
R
Y
T
R
T
R
----
D
L
Y
D
D
F
A
N
V
L
S
Q
V
D
V
L
L
M
L
D
V
Y
A
A
G
E
P
P
-
I
P
-
G
A
D
S
R
A
L
C
R
T
I
R
N
R
G
K
L
D
P
I
-
L
V
P
D
S
E
-
S
A
P
E
M
L
A
Q
I
L
N
G
E
D
--
L
I
L
V
Q
G
A
G
N
I
G
K
I
A
R
K
L
A
E
--
H
K
L
Q
P
Q
-------------------------------------------------------------
4
PsiBlast_PDB
61.47
43%
-93
- C1 -
1P3D
4
MURC_HAEIN
A:
[21-222]
------------------------------------------
I
H
F
I
G
I
G
G
A
G
M
S
G
--
I
A
E
I
L
L
N
E
G
Y
Q
I
S
G
S
D
I
A
D
---
G
V
V
-
T
Q
-
R
--
L
A
Q
A
G
A
K
I
Y
-
I
------------
G
H
--
A
E
E
-
H
I
--
E
G
--
A
S
V
V
V
V
S
S
A
I
K
D
D
-----
N
--
P
E
L
V
T
S
K
Q
K
R
-
I
P
V
I
Q
R
A
Q
M
L
A
E
-
I
M
-
R
--
F
R
H
G
I
A
V
A
G
T
H
G
K
T
-
T
T
T
A
M
I
S
M
-
I
Y
T
Q
A
K
L
D
P
T
F
V
N
-------------
G
G
-
L
-
V
---------
K
------------------------
S
A
-------------------------------
G
----------
K
-----------
N
---
A
------
H
----------
L
---------
G
A
S
R
Y
L
I
A
E
A
D
-
E
S
-
D
--
A
-
S
-------
F
L
-------
H
L
Q
--
P
M
V
S
V
V
T
N
M
E
P
D
H
M
D
T
Y
E
G
-
D
F
E
K
-----
M
K
A
T
Y
V
K
F
L
H
N
L
----
P
---
F
Y
G
L
--
A
V
-
M
C
A
D
D
---
P
----
V
---
L
---------
M
E
L
------
V
P
K
V
G
R
Q
V
I
T
Y
G
F
S
E
Q
A
D
Y
R
-
I
E
D
Y
E
Q
T
G
F
Q
G
H
Y
T
V
I
C
P
N
N
E
R
I
N
V
L
L
N
V
P
G
K
H
N
A
L
N
A
T
A
A
L
A
V
A
K
E
E
G
I
A
N
E
A
I
L
E
A
L
A
D
F
Q
G
A
G
R
R
F
D
Q
L
G
E
F
I
R
P
N
G
K
V
R
L
V
D
D
Y
G
H
H
P
T
E
V
G
V
T
I
K
A
A
--
R
---
E
---
G
W
--
G
D
K
R
I
V
M
I
F
Q
P
H
R
Y
S
R
T
R
D
L
F
D
D
----
F
V
Q
V
L
S
Q
V
D
A
L
I
M
L
D
V
Y
A
A
G
E
A
P
I
V
G
A
D
-
S
K
-
S
L
C
R
S
I
R
N
L
G
K
V
D
P
I
L
V
S
D
T
-
S
Q
L
G
D
V
-
L
D
Q
I
I
Q
D
G
D
L
I
L
A
Q
--
G
A
G
S
V
S
K
I
S
R
G
L
A
E
S
W
------------------------------------------------------------------------
5
PsiBlast_PDB
61.03
40%
-98
- C1 -
2F00
1
MURC_ECOLI
A:
[22-223]
------------------------------------------
I
H
F
V
G
I
G
G
A
G
M
G
G
--
I
A
E
V
L
A
N
E
G
Y
Q
I
S
G
S
D
L
A
P
---
N
P
V
-
T
Q
-
Q
--
L
M
N
L
G
A
T
I
Y
-
F
------------
N
H
--
R
P
E
-
N
V
--
R
D
--
A
S
V
V
V
V
S
S
A
I
S
A
D
-----
N
--
P
E
I
V
A
A
H
E
A
R
-
I
P
V
I
R
R
A
E
M
L
A
E
-
L
M
-
R
--
F
R
H
G
I
A
I
A
G
T
H
G
K
T
-
T
T
T
A
M
V
S
S
-
I
Y
A
E
A
G
L
D
P
T
F
V
N
-------------
G
G
-
L
-
V
---------
K
------------------------
A
A
-------------------------------
G
----------
V
-----------
H
---
A
------
R
----------
L
---------
G
H
G
R
Y
L
I
A
E
A
D
-
E
S
-
D
--
A
-
S
-------
F
L
-------
H
L
Q
--
P
M
V
A
I
V
T
N
I
E
A
D
H
M
D
T
Y
Q
G
-
D
F
E
N
-----
L
K
Q
T
F
I
N
F
L
H
N
L
----
P
---
F
Y
G
R
--
A
V
-
M
C
V
D
D
---
P
----
V
---
I
---------
R
E
L
------
L
P
R
V
G
R
Q
T
T
T
Y
G
F
S
E
D
A
D
V
R
-
V
E
D
Y
Q
Q
I
G
P
Q
G
H
F
T
L
L
R
Q
D
K
E
P
M
R
V
T
L
N
A
P
G
R
H
N
A
L
N
A
A
A
A
V
A
V
A
T
E
E
G
I
D
D
E
A
I
L
R
A
L
E
S
F
Q
G
T
G
R
R
F
D
F
L
G
E
F
P
L
E
P
V
N
G
K
S
G
T
A
M
L
V
D
D
Y
G
H
H
P
T
E
V
D
A
--
T
---
I
---
K
A
--
A
R
A
G
W
P
D
K
N
L
V
M
L
F
Q
P
H
R
F
T
R
T
R
----
D
L
Y
D
D
F
A
N
V
L
T
Q
V
D
T
L
L
M
L
E
V
Y
P
A
G
E
A
P
-
I
P
-
G
A
D
S
R
S
L
C
R
T
D
P
I
L
V
P
D
P
A
R
-
V
A
E
M
L
A
-
P
V
L
T
G
N
D
L
I
L
V
Q
G
A
--
G
N
I
G
K
I
A
R
S
L
A
E
I
K
L
K
P
Q
----------------------------------------------------------------------
32
HHSearch
60.42
16%
-94
- C1 -
2VOS
8
?
A:
[63-473]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
Y
P
S
I
H
I
A
G
T
N
G
K
T
-
S
V
A
R
M
V
D
A
-
L
V
T
A
L
H
R
R
T
G
R
T
T
S
PHLQSPVERISI
D
G
-
K
P
I
---------
S
------------------------
P
A
Q
Y
V
A
T
Y
R
E
I
E
P
L
V
A
L
I
D
Q
Q
S
Q
A
S-------------------
P
AMS
K
F
E
V
L
T
A
M
A
F
A
A
F
------
A
----------
D
---------
A
P
V
D
V
A
V
V
E
V
G
-
M
G
-
G
RW
D
-
A
-------
T
N
-------
V
I
N
--
A
P
V
A
V
I
T
P
I
S
I
D
H
V
D
Y
L
-
G
A
D
I
A
G
-----
I
A
G
E
K
A
G
I
I
T
R
A
PSP
D
T
---
V
A
V
I
G
R
Q
V
-
P
K
V
M
E
---
V
L
L
A
E
S
---
V
---------
R
A
D
------
A
S
V
A
R
E
--------------------------------
D
S
E
F
A
V
L
R
R
Q
I
A
V
G
G
Q
V
L
Q
L
Q
G
L
G
G
---------------------------------
V
Y
S
D
I
Y
L
P
L
H
G
E
H
Q
A
H
N
A
V
L
A
L
A
S
V
E
A
--
F
F
GA
Q
---
L
D
--
G
D
A
V
R
A
G
F
A
A
V
-
T
S
P
G
R
L
E
R
M
R
S
------
A
P
T
V
F
I
D
A
A
H
N
P
A
G
A
S
A
L
A
Q
T
L
A
H
E
F
D
F
R
-
F
L
V
G
V
L
S
V
L
G
D
---
K
D
-
V
D
G
-
I
L
A
A
L
E
P
V
F
D
S
V
V
V
T
H
N
G
S
P
R
-------
A
L
D
V
E
A
L
A
L
A
A
G
E
R
F-
G
P
D
R
V
R
T
A
E
N
L
R
D
A
I
D
V
A
T
S
L
---
V
D
D
A
A
A
DPDVAG--
R
T
G
I
V
I
T
G
S
V
V
T
A
G
A
A
R
T
L
F
G
R
D
P
Q
----
55
Fugue
53.19
14%
-75
- C1 -
2VOS
8
?
A:
[22-487]
D
E
I
A
S
L
L
Q
V
E
H
L
L
D
Q
R
W
R
I
D
P
S
L
T
R
I
S
A
L
M
D
L
L
GSPQR
S
Y
P
S
I
H
I
A
G
T
N
G
K
T
S
V
A
R
M
V
D
A
L
V
T
A
L
H
R
R
--------------------------------------------------------------
T
G
R
T
T
S
P
H
L
Q
S
-----
P
--
V
E
R
I
S
I
D
G
K
P
-
I
S
P
A
Q
Y
V
A
T
Y
R
E
-
I
E
-
P
--
L
V
A
L
I
D
Q
Q
S
Q
A
S
P
A
M
S
K
F
E
V
L
T
A
M
A
F
A
A
F
A
D
A
---------------------------------------------------------------------------------------------------------------------------------------------------
P
V
D
V
A
V
V
E
V
G
M
G
G
-
R
W-
D
-
A
-------
T
N
-------
V
I
N
--
A
P
V
A
V
I
T
P
I
S
I
D
H
V
D
Y
L
-
G
--------------------
A
D
----
I
---
A
G
I
A
--
G
E
-
K
A
G
I
--------------------------------
I
T
R
A
P
S
P
D
T
V
A
V
I
G
R
Q
V
P
K
V
M
E
V
L
L
A
E
S
V
R
A
D
A
S
V
A
R
E
D
S
E
F
A
V
L
R
R
Q
I
A
V
G
G
Q
V
L
Q
L
Q
G
L
--------------------------------
G
G
V
Y
S
D
I
Y
L
P
L
-
H
G
E
H
Q
A
H
N
A
V
L
A
L
A
S
V
E
A
--
F
---
F
GAQ
L
D
--
G
D
A
V
R
A
G
F
A
A
V
T
S
P
G
R
----
L
E
R
M---
R
S
A
P
T
V
F
I
D
A
A
H
N
P
A
G
A
S
A
L
A
Q
T
L
A
H
E
F
-
D
F
R
F
L
V
G
V
L
S
V
L
G
D
K
D
V
D
G
I
L
A
A
-
L
E
P
----
V
F
D
S
V
V
V
T
H
N
G
S
P
R
AL
D
V
E
A
L
A
L
A
A
G
E
R
F
G
P
D
R
V
R
--
T
A
E
N
L
R
D
A
I
D
V
A
T
S
L
V
D
D
A
A
A
DPD
V
-----------
A
G
R
T
G
I
V
I
T
G
S
V
V
T
A
G
A
A
R
T
L
F
G
R
D
P
Q
----
24
HHSearch
47.98
29%
10
- C1 -
1J6U
-
MURC_THEMA
A:
[0-444]
---------------------------------------
H
M
K
I
H
F
V
G
I
G
G
I
G
M
S
A
--
V
A
L
H
E
F
S
N
G
N
D
V
Y
G
S
N
I
E
E
---
T
E
R
-
T
A
-
Y
--
L
R
K
L
G
I
P
I
F
-
V
------------
P
H
--
S
A
D
-
N
W
--
Y
D
--
P
D
L
V
I
K
T
P
A
V
R
D
D
-----
N
--
P
E
I
V
R
A
R
M
E
R
-
V
P
I
E
N
R
L
H
Y
F
R
D
-
T
L
-
K
R
E
K
K
E
E
F
A
V
T
G
T
D
G
K
T
-
T
T
T
A
M
V
A
H
-
V
L
K
H
L
R
K
S
P
T
V
F
L
-------------
G
G
-
I
-
M
---------
D
------------------------
S
L
-------------------------------
E
----------
H
-----------
G
---
N
------
Y
----------
E
---------
K
G
N
G
P
V
V
Y
E
L
D
-
E
S
-
E
--
E
-
F
-------
F
S
-------
E
F
S
--
P
N
Y
L
I
I
T
N
A
R
G
D
H
L
E
N
Y
-
G
N
S
L
T
R
-----
Y
R
S
A
F
E
K
I
S
R
N
T
----
D
---
L
V
V
T
F
A
E
D
-
E
L
T
S
H
----------------------
L
G
D
------
V
T
F
G
V
K
K
--------------------------------
G
T
Y
T
L
E
M
R
S
A
S
R
A
E
Q
K
A
M
V
E
K
N
G
K
---------------------------------
R
Y
L
E
L
K
L
K
V
P
G
F
H
N
V
L
N
A
L
A
V
I
A
L
F
D
S
--
L
---
G
---
Y
D
--
L
A
P
V
L
E
A
L
E
E
F
R
G
V
H
R
R
F
S
I
A
F
H
DP--
E
T
N
I
Y
V
I
D
D
Y
A
H
T
P
D
E
I
R
N
L
L
Q
T
A
K
E
V
F
E
N
E
-
K
I
V
V
I
F
Q
P
H
R
--------
G
N
-
F
A
K
A
L
Q
-
L
A
D
E
V
V
V
T
E
V
Y
D
-----------
S
G
K
M
I
W
D
S
L
K
S
L
--
G
K
E
-
A
Y
F
V
E
K
L
P
E
L
E
K
V
I
--
S
---
V
-----------
S
E
N
T
V
F
L
F
V
G
A
G
D
-
I
I
Y
S
S
R
R
F
V
E
R
Y
Q
S
S
K
-
25
HHSearch
47.36
22%
-2
- C1 -
3HN7
-
?
A:
[0-500]
---------------------------------------
G
M
H
I
H
I
L
G
I
C
G
T
F
M
G
S
--
L
A
L
L
A
R
A
L
G
H
T
V
T
G
S
D
A
N
I
---
Y
P
P
M
S
T
-
Q
--
L
E
Q
A
G
V
T
I
E
-
E
------------
G
Y
--
L
I
A
-
H
L
Q-
P
A
--
P
D
L
V
V
V
G
N
A
M
K
R
G
-----
M
--
D
V
I
E
Y
M
L
D
T
G
-
L
R
Y
T
S
G
P
Q
F
L
S
E
-
Q
V
L
Q
--
S
R
H
V
I
A
V
A
G
T
H
G
K
T
-
T
T
T
T
M
L
A
W
-
I
L
H
Y
A
G
I
D
A
G
F
L
I
-------------
G
G
-
V
-
P
---------
L
------------------------
V
N
TT-----------------------------
D
----------
T
-----------
N
L
Q
-
Q
V
F
AHSS
Y
LGTEKDDSDN
S
---------
V
N
T
G
Y
F
V
I
E
A
D
-
E
Y
-
D
--
S
-
A
FFDKRS
K
F
V
-------
H
Y
R
--
P
R
T
A
I
L
N
N
L
E
F
D
--------
D
L
D
A
-----
I
Q
T
Q
F
H
H
M
V
R
M
I
PST-
G
---
K
I
I
M
P
A
A
T
-
I
S
L
E
D
---
T
----
L
---
A
K
GVW
T
P
I
W
R
T
S
V
------
I
D
-----------------------------------
N
S
S
D
W
Q
A
E
L
I
S
--
A
D
G
S
Q
F
T
V
S
F
N
D
N
-------------------------------
K
E
A
T
A
L
V
N
W
S
M
S
G
L
H
N
V
N
N
A
L
V
A
I
A
A
A
Y
N
--
I
---
G
---
V
S
--
V
K
T
A
C
A
A
L
S
A
F
A
G
I
K
R
R
M
E
L
I
G
D
----
V
N
D
I
L
V
F
D
D
F
A
H
H
P
T
A
I
T
T
T
L
D
G
A
K
K
K
L
A
D
R
-
R
L
W
A
I
I
E
P
R
S
N
T
M
K
M
G
I
H
Q
D
S
L
A
Q
S
A
T
-
L
A
D
H
T
L
W
Y
E
P
T
G
L
E
--
W
G
L
------
K
E
V
I
D
N
A
T
I
A
NP
S
I
G
S
Q
Q
V
L
S
S
V
D
D
I
I
K
H
I
C
T
H
---
A
-----------
K
A
G
D
A
I
V
I
M
S
N
G
G
-
F
E
G
I
H
Q
R
L
L
T
A
L
G
N
I
V
A
13
PsiBlast_PDB
44.52
23%
-65
- C1 -
4BUC
14
MURD_THEMA
A:
[23-222]
------------------------------------------
I
G
F
L
G
F
G
K
S
N
R
S
L
--
L
K
Y
L
L
N
H
Q
E
A
K
F
F
V
S
E
A
K
T
---
L
D
G
-
E
T
-
K
K
F
L
E
E
H
S
V
E
Y
E
-
E
------------
G
G
--
H
T
E
-
K
L
--
L
D
--
C
D
V
V
Y
V
S
P
G
I
K
P
D
-----
T
S
M
I
E
L
L
S
S
R
G
V
K
L
S
T
E
L
Q
---
F
F
L
D
-
N
V
-
D
--
P
K
K
V
V
G
I
T
G
T
D
G
K
S
-
T
A
T
A
L
M
Y
H
-
V
L
--
S
G
R
G
F
K
T
F
L
-------------
G
G
-
N
-
F
---------
G
------------------------
T
P
-------------------------------
A
----------
V
-----------
E
---
A
------
L
----------
E
---------
G
E
Y
D
Y
Y
V
L
E
M
S
-
S
F
-
Q
--
L
-
F
-------
W
S
-------
E
R
P
YL
S
N
F
L
V
L
-
N
I
S
E
D
H
L
D
W
H
-
S
-
S
F
K
E
Y
V
D
S
K
L
K
P
A
F
L
Q
T
E
G
D
L
----
F
---
V
Y
N
K
--
H
I
-
E
R
L
R
N
---
L
----
E
---
G
---------
V
R
S
------
R
K
I
P
F
W
T
D
E
N
F
A
T
E
K
E
L
I
V
R
-
G
K
K
Y
T
L
P
G
N
Y
P
Y
Q
M
R
E
N
I
L
A
V
S
V
L
Y
M
E
M
F
N
E
L
E
S
F
L
E
L
L
R
D
F
K
P
L
P
H
R
M
E
Y
L
G
Q
I
D
G
R
H
F
Y
N
D
S
K
A
T
S
T
H
A
V
L
G
A
L
S
N
F
D
K
V
V
L
I
M
C
G
I
G
K
K
E
N
Y
S
L
F
V
E
K
A
--
S
---
P
---
K
L
--
K
H
L
I
M
F
G
E
I
S
K
E
L
A
P
F
V
G
K
I
P
H
S
----
I
V
E
N
M
E
E
A
F
E
K
A
M
E
V
S
E
K
G
D
V
I
L
L
S
P
G
G
-
A
S
-
F
A
K
R
G
E
H
F
R
E
I
F
K
R
H
G
G
D
------------------------------------------------------------------------------------------------------------------
37
HHSearch
44.34
17%
-94
- C1 -
3MVN
-
?
A:
[317-451]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
L
E
V
K
G
V
----
V
N
N
I
T
V
Y
D
D
F
A
H
H
P
T
A
I
T
A
T
I
D
A
L
R
A
K
V
G
Q
Q
-
R
I
L
A
V
L
E
P
R
--------
K
H
E
-
L
A
T
S
L
Q
-
D
A
D
S
V
F
I
Y
Q
P
-----------
W
Q
----
V
S
E
V
L
A
N
L
---
A
Q
P
A
I
S
A
D
D
V
D
E
L
V
M
R
I
V
Q
Q
---
A
-----------
K
P
N
D
H
I
L
I
M
S
N
G
A
-
F
G
G
I
H
Q
K
L
L
T
A
L
-----
47
HHSearch
42.59
16%
-105
- C1 -
3OJO
1
?
A:
[12-146]
----------------------------------------
S
K
L
T
V
V
G
L
G
Y
I
G
L
-
P
--
T
S
I
M
F
A
K
H
G
V
D
V
L
G
V
D
I
N
Q
---
Q
T
--
I
D
-
K
--
L
Q
N
G
Q
I
S
I
E
E
P
G
L
Q
E
V
Y
E
E
V
L
S
S
G
K
L
K
V
S
T
-
T
P
--
E
A
--
S
D
V
F
I
I
A
V
P
T
P
N
N
DDQYR
S
--
C
D
I
S
L
V
M
R
-----
A
L
---
D
S
I
L
P
-
F
L
-
K
--
K
G
N
T
I
I
V
E
S
T
I
A
P
K
-
T
M
D
D
F
V
K
P
-
V
I
E
N
L
G
F
T
I
G
E
D
I
-------------
Y
L
-
V
-
H
---------
C
------------------------
P
E
-------------------------------
R
----------
V
-----------
L
---
P
------
G
----------
K
---------
I
L
E
E
L
V
H
N
N
R
I
-
I
G
-
G
--
V
-
T
-------
K
A
-------
C
I
E
--
A
G
K
R
V
Y
R
T
F
V
Q
G
E
M
I
E
T
-
D
-
A
R
T
A
-----
E
M
S
K
L
M
E
N
T
Y
R
D
----
V
---
N
I
A
L
--
A
N
-
E
L
T
K
I
---
C
----
N
---
N
---------
L
N
I
------
N
V
L
D
V
I
E
M
A
N
K
H
P
R
V
N
I
H
Q
P
-
G
P
G
V
G
G
H
C
L
A
V
D
P
N
A
K
L
I
Q
T
G
R
E
I
N
N
S
M
P
A
Y
V
V
D
T
T
K
Q
I
I
K
A
L
S
G
N
K
V
T
V
F
G
L
T
Y
K
G
D
V
D
D
I
R
E
S
P
A
F
D
I
Y
E
L
L
N
Q
E
P
D
I
E
V
C
A
Y
D
P
H
V
E
L
D
F
V
E
H
D
M
S
H
A
V
--
K
---
D
---
A
S
--
L
V
L
I
L
S
D
H
S
E
F
K
N
L
S
D
S
H
F
D
K
M
K
----
H
K
V
I
F
D
T
K
N
V
V
K
S
S
F
E
D
V
L
Y
Y
N
Y
G
N
I
F
N
-
F
I
-------------------------------------------------------------------------------------------------------------------------------------