@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : Wbm0184: (2015-11-29 )
MPSNVKLLEARLKAEYYTVIVAHDSEEAIDLVAKQQPDIILLDIMMPKINGFKVCKNLKSTPLTTHIPIIMVTALHDTHDRVQGINAGADDFLTKPIDETALSARIKSLTRLKMVIDELRLRGETNAEICGVAGSSIMDYSNQIFDSNILVVDEDIFQAEQIHNVLKQRFKLINILNDPMEALKVGIEDNYDLIISDMQFSETDGLRLCSEFRSKVETRYTPILILSEDYNKNNLVKALDVGANDYLTVPLDESELIARVNLQVKRKRYQDALRMNLFNNAEMSIKDPLTNCYNRRYFDTHLRNIIKDSVEKNRRLSLMILDIDYFKIVNDDFGHSAGDELLKQIQKRISENIRVTDLLARFGGEEFVVVMPDTNISDAYIVAERIREIIATEPFILSDKNTTHNVTVSIGVVEMQESDLDNIEKFIVRADRYLYKAKNSGRNRVVTS
Atome Classification :
(20 SA)
---------.........10........20........30........40........50........60........70........80........90........100.......110.......120.......130.....-..140.......150.......160.......170-.......180.......190.......200.......210.......220.......230.....--..240.......250.......260...---------------....270.......280.......290.......300.......310....----...320.......330.......340.......350.-......360.......370...-----....380.......390.--......400.......410.....-..420.......-430.......440......---
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
---------MPS
N
V
K
L
L
E
A
R
LKA
E
Y
Y
T
V
I
V
AHDS
E
E
A
I
D
L
V
AKQQP
D
I
I
L
L
D
IMMPKI
N
G
F
K
V
C
K
NLKSTPLTTHI
P
I
I
M
V
T
A
LHD
T
H
D
R
VQGINAG
A
D
D
FLTK
P
I
D
E
T
A
L
S
A
R
I
K
S
L
T
R
L
K
M
V
I
D
E
L
RLRGETNA
E
I
CGVAG
S
S
I
-
M
D
Y
S
N
QIFDSN
I
L
V
VD
E
D
I
F
Q
A
E
Q
I
H
N
V
L
K
Q
R
F
K
L
-
I
N
I
LND
P
M
E
A
L
K
VGIEDN
Y
D
L
I
I
SDMQFSET
D
G
L
R
L
C
S
E
F
R
S
K
V
ETRY
T
P
I
L
I
L
SEDYNKNN
L
V
K
--
A
L
DVGAN
D
Y
L
T
VPL
D
E
S
E
L
I
A
R
VN
L
Q
V
K
---------------
R
K
R
Y
Q
D
A
L
R
M
N
LFNNA
E
M
S
IKD
P
L
T
N
C
Y
N
R
R
Y
F
D
T
H
L
R
N
I
I
K
D
S
V
EKNR
R
L
----
S
L
M
I
L
D
I
D
Y
F
K
I
VNDDFGH
S
A
G
D
E
L
L
K
Q
I
Q
K
R
I
SENI-
R
V
T
D
L
L
A
R
FGG
E
E
F
V
V
V
MPDTN-----IS
D
A
Y
I
V
A
E
R
I
R
E
I
IATE--
P
F
I
LSDKNTT
H
N
V
T
V
S
I
G
V
V
EMQE-S
D
L
D
N
I
E
K
F
I
V
R
-
A
D
R
Y
L
Y
KAKNSGRNRVVTS---
23
PsiBlast_CBE
90.22
43%
-101
- C6 -
2WB4
10
PLED_CAUCN
B:
[13-450]
-----------
A
N
V
R
L
L
E
A
K
L
T
A
E
Y
Y
E
V
S
T
A
M
D
G
P
T
A
L
A
M
A
A
R
D
L
P
D
I
I
L
L
D
V
M
M
P
G
M
D
G
F
T
V
C
R
K
L
K
D
D
P
T
T
R
H
I
P
V
V
L
I
T
A
L
D
G
R
G
D
R
I
Q
G
L
E
S
G
A
S
D
F
L
T
K
P
I
D
D
V
M
L
F
A
R
V
R
S
L
T
R
F
K
L
V
I
D
E
L
R
Q
R
E
A
S
G
------------
L
D
G
----
L
G
G
R
V
L
I
V
D
D
N
E
R
Q
A
Q
R
V
A
A
E
L
G
V
E
H
R
P
-
V
-
I
E
S
D
P
-
E
K
A
K
I
S
A
G
G
P
V
D
L
V
I
V
N
A
A
A
K
N
F
D
G
L
R
F
T
A
A
L
R
S
E
E
R
T
R
Q
L
P
V
L
A
M
V
D
P
D
D
R
G
R
M
V
K
--
A
L
E
I
G
V
N
D
I
L
S
R
P
I
D
P
Q
E
L
S
A
R
V
K
T
Q
I
Q
---------------
R
K
R
Y
T
D
Y
L
R
N
N
L
D
H
S
L
E
L
A
V
T
D
Q
L
T
G
L
H
N
R
R
Y
M
T
G
Q
L
D
S
L
V
K
R
A
T
L
G
G
D
P
V
----
S
A
L
L
I
D
I
D
F
F
K
K
I
N
D
T
F
G
H
D
I
G
D
E
V
L
R
E
F
A
L
R
L
A
S
N
V
-
R
A
I
D
L
P
C
R
Y
G
G
E
E
F
V
V
I
M
P
D
T
A
-----
L
A
D
A
L
R
I
A
E
R
I
R
M
H
V
S
G
S
--
P
F
T
V
A
H
G
R
E
M
L
N
V
T
I
S
I
G
-
V
S
A
T
A
-
G
E
G
D
T
P
E
A
L
L
K
R
-
A
D
E
G
V
Y
Q
A
K
A
S
G
R
N
A
V
V
G
K
---
3
PsiBlast_PDB
88.84
43%
-100
- C5 -
2WB4
9
PLED_CAUCN
A:
[13-450]
-----------
A
N
V
R
L
L
E
A
K
L
T
A
E
Y
Y
E
V
S
T
A
M
D
G
P
T
A
L
A
M
A
A
R
D
L
P
D
I
I
L
L
D
V
M
M
P
G
M
D
G
F
T
V
C
R
K
L
K
D
D
P
T
T
R
H
I
P
V
V
L
I
T
A
L
D
G
R
G
D
R
I
Q
G
L
E
S
G
A
S
D
F
L
T
K
P
I
D
D
V
M
L
F
A
R
V
R
S
L
T
R
F
K
L
V
I
D
E
L
R
Q
R
E
A
S
G
R
R
M
G
V
I
A
G
A
A
A
R
L
D
G
----
L
G
G
R
V
L
I
V
D
D
N
E
R
Q
A
Q
R
V
A
A
E
L
G
V
E
H
R
P
-
V
-
I
E
S
D
P
-
E
K
A
K
I
S
A
G
G
P
V
D
L
V
I
V
N
A
A
A
K
N
F
D
G
L
R
F
T
A
A
L
R
S
E
E
R
T
R
Q
L
P
V
L
A
M
V
D
P
D
D
R
G
R
M
V
K
--
A
L
E
I
G
V
N
D
I
L
S
R
P
I
D
P
Q
E
L
S
A
R
V
K
T
Q
I
Q
---------------
R
K
R
Y
T
D
Y
L
R
N
N
L
D
H
S
L
E
L
A
V
T
D
Q
L
T
G
L
H
N
R
R
Y
M
T
G
Q
L
D
S
L
V
K
R
A
T
L
G
G
D
P
V
----
S
A
L
L
I
D
I
D
F
F
K
K
I
N
D
T
F
G
H
D
I
G
D
E
V
L
R
E
F
A
L
R
L
A
S
N
V
-
R
A
I
D
L
P
C
R
Y
G
G
E
E
F
V
V
I
M
P
D
T
A
-----
L
A
D
A
L
R
I
A
E
R
I
R
M
H
V
S
G
S
--
P
F
T
V
A
H
G
R
E
M
L
N
V
T
I
S
I
G
-
V
S
A
T
A
-
G
E
G
D
T
P
E
A
L
L
K
R
-
A
D
E
G
V
Y
Q
A
K
A
S
G
R
N
A
V
V
G
K
---
22
PsiBlast_CBE
88.22
43%
-89
- C5 -
1W25
3
PLED_CAUCN
B:
[12-449]
-----------
A
N
V
R
L
L
E
A
K
L
T
A
E
Y
Y
E
V
S
T
A
M
D
G
P
T
A
L
A
M
A
A
R
D
L
P
D
I
I
L
L
D
V
M
M
P
G
M
D
G
F
T
V
C
R
K
L
K
D
D
P
T
T
R
H
I
P
V
V
L
I
T
A
L
D
G
R
G
D
R
I
Q
G
L
E
S
G
A
S
D
F
L
T
K
P
I
D
D
V
M
L
F
A
R
V
R
S
L
T
R
F
K
L
V
I
D
E
L
R
Q
R
E
A
S
G
R
R
M
G
V
I
A
G
A
A
A
R
L
D
G
----
L
G
G
R
V
L
I
V
D
D
N
E
R
Q
A
Q
R
V
A
A
E
L
G
V
E
H
R
P
-
V
-
I
E
S
D
P
-
E
K
A
K
I
S
A
G
G
P
V
D
L
V
I
V
N
A
A
A
K
N
F
D
G
L
R
F
T
A
A
L
R
S
E
E
R
T
R
Q
L
P
V
L
A
M
V
D
P
D
D
R
G
R
M
V
K
--
A
L
E
I
G
V
N
D
I
L
S
R
P
I
D
P
Q
E
L
S
A
R
V
K
T
Q
I
Q
---------------
R
K
R
Y
T
D
Y
L
R
N
N
L
D
H
S
L
E
L
A
V
T
D
Q
L
T
G
L
H
N
R
R
Y
M
T
G
Q
L
D
S
L
V
K
R
A
T
L
G
G
D
P
V
----
S
A
L
L
I
D
I
D
F
F
K
K
I
N
D
T
F
G
H
D
I
G
D
E
V
L
R
E
F
A
L
R
L
A
S
N
V
-
R
A
I
D
L
P
C
R
Y
G
G
E
E
F
V
V
I
M
P
D
T
A
-----
L
A
D
A
L
R
I
A
E
R
I
R
M
H
V
S
G
S
--
P
F
T
V
A
H
G
R
E
M
L
N
V
T
I
S
I
G
-
V
S
A
T
A
-
G
E
G
D
T
P
E
A
L
L
K
R
-
A
D
E
G
V
Y
Q
A
K
A
S
G
R
N
A
V
V
G
K
---
2
PsiBlast_PDB
88.19
43%
-97
- C5 -
2V0N
13
PLED_CAUCN
A:
[12-449]
-----------
A
N
V
R
L
L
E
A
K
L
T
A
E
Y
Y
E
V
S
T
A
M
D
G
P
T
A
L
A
M
A
A
R
D
L
P
D
I
I
L
L
D
V
M
M
P
G
M
D
G
F
T
V
C
R
K
L
K
D
D
P
T
T
R
H
I
P
V
V
L
I
T
A
L
D
G
R
G
D
R
I
Q
G
L
E
S
G
A
S
D
F
L
T
K
P
I
D
D
V
M
L
F
A
R
V
R
S
L
T
R
F
K
L
V
I
D
E
L
R
Q
R
E
A
S
G
R
R
M
G
V
I
A
G
A
A
A
R
L
D
G
----
L
G
G
R
V
L
I
V
D
D
N
E
R
Q
A
Q
R
V
A
A
E
L
G
V
E
H
R
P
-
V
-
I
E
S
D
P
-
E
K
A
K
I
S
A
G
G
P
V
D
L
V
I
V
N
A
A
A
K
N
F
D
G
L
R
F
T
A
A
L
R
S
E
E
R
T
R
Q
L
P
V
L
A
M
V
D
P
D
D
R
G
R
M
V
K
--
A
L
E
I
G
V
N
D
I
L
S
R
P
I
D
P
Q
E
L
S
A
R
V
K
T
Q
I
Q
---------------
R
K
R
Y
T
D
Y
L
R
N
N
L
D
H
S
L
E
L
A
V
T
D
Q
L
T
G
L
H
N
R
R
Y
M
T
G
Q
L
D
S
L
V
K
R
A
T
L
G
G
D
P
V
----
S
A
L
L
I
D
I
D
F
F
K
K
I
N
D
T
F
G
H
D
I
G
D
E
V
L
R
E
F
A
L
R
L
A
S
N
V
-
R
A
I
D
L
P
C
R
Y
G
G
E
E
F
V
V
I
M
P
D
T
A
-----
L
A
D
A
L
R
I
A
E
R
I
R
M
H
V
S
G
S
--
P
F
T
V
A
H
G
R
E
M
L
N
V
T
I
S
I
G
-
V
S
A
T
A
-
G
E
G
D
T
P
E
A
L
L
K
R
-
A
D
E
G
V
Y
Q
A
K
A
S
G
R
N
A
V
V
G
K
---
75
HHSearch
87.74
43%
-90
- C5 -
1W25
4
PLED_CAUCN
A:
[14-451]
-------------
V
R
L
L
E
A
K
L
T
A
E
Y
Y
E
V
S
T
A
M
D
G
P
T
A
L
A
M
A
A
R
D
L
P
D
I
I
L
L
D
V
M
M
P
G
M
D
G
F
T
V
C
R
K
L
K
D
D
P
T
T
R
H
I
P
V
V
L
I
T
A
L
D
G
R
G
D
R
I
Q
G
L
E
S
G
A
S
D
F
L
T
K
P
I
D
D
V
M
L
F
A
R
V
R
S
L
T
R
F
K
L
V
I
D
E
L
R
Q
R
E
A
S
G
R
R
M
G
V
I
A
G
----
A
A
A
R
L
D
G
L
G
G
R
V
L
I
V
D
D
N
E
R
Q
A
Q
R
V
A
A
E
L
G
V
E
H
R
P
-
V
I
-
E
S
D
-
P
E
K
A
K
I
S
A
G
G
P
V
D
L
V
I
V
N
A
A
A
K
N
F
D
G
L
R
F
T
A
A
L
R
S
E
E
R
T
R
Q
L
P
V
L
A
M
V
D
P
D
D
R
G
R
M
V
K
--
A
L
E
I
G
V
N
D
I
L
S
R
P
I
D
P
Q
E
L
S
A
R
V
K
T
Q
I
Q
---------------
R
K
R
Y
T
D
Y
L
R
N
N
L
D
H
S
L
E
L
A
V
T
D
Q
L
T
G
L
H
N
R
R
Y
M
T
G
Q
L
D
S
L
V
K
R
A
T
L
G
G
D
P
V
----
S
A
L
L
I
D
I
D
F
F
K
K
I
N
D
T
F
G
H
D
I
G
D
E
V
L
R
E
F
A
L
R
L
A
S
N
V
-
R
A
I
D
L
P
C
R
Y
G
G
E
E
F
V
V
I
M
P
D
T
A
-----
L
A
D
A
L
R
I
A
E
R
I
R
M
H
V
S
G
S
--
P
F
T
V
A
H
G
R
E
M
L
N
V
T
I
S
I
G
V
S
A
T
A
G
--
E
G
D
T
P
E
A
L
L
K
R
-
A
D
E
G
V
Y
Q
A
K
A
S
G
R
N
A
V
V
G
K
---
21
PsiBlast_CBE
87.48
43%
-97
- C6 -
2V0N
9
PLED_CAUCN
B:
[12-449]
-----------
A
N
V
R
L
L
E
A
K
L
T
A
E
Y
Y
E
V
S
T
A
M
D
G
P
T
A
L
A
M
A
A
R
D
L
P
D
I
I
L
L
D
V
M
M
P
G
M
D
G
F
T
V
C
R
K
L
K
D
D
P
T
T
R
H
I
P
V
V
L
I
T
A
L
D
G
R
G
D
R
I
Q
G
L
E
S
G
A
S
D
F
L
T
K
P
I
D
D
V
M
L
F
A
R
V
R
S
L
T
R
F
K
L
V
I
D
E
L
R
Q
R
E
A
S
G
R
R
M
G
V
I
A
G
A
A
A
R
L
D
G
----
L
G
G
R
V
L
I
V
D
D
N
E
R
Q
A
Q
R
V
A
A
E
L
G
V
E
H
R
P
-
V
-
I
E
S
D
P
-
E
K
A
K
I
S
A
G
G
P
V
D
L
V
I
V
N
A
A
A
K
N
F
D
G
L
R
F
T
A
A
L
R
S
E
E
R
T
R
Q
L
P
V
L
A
M
V
D
P
D
D
R
G
R
M
V
K
--
A
L
E
I
G
V
N
D
I
L
S
R
P
I
D
P
Q
E
L
S
A
R
V
K
T
Q
I
Q
---------------
R
K
R
Y
T
D
Y
L
R
N
N
L
D
H
S
L
E
L
A
V
T
D
Q
L
T
G
L
H
N
R
R
Y
M
T
G
Q
L
D
S
L
V
K
R
A
T
L
G
G
D
P
V
----
S
A
L
L
I
D
I
D
F
F
K
K
I
N
D
T
F
G
H
D
I
G
D
E
V
L
R
E
F
A
L
R
L
A
S
N
V
-
R
A
I
D
L
P
C
R
Y
G
G
E
E
F
V
V
I
M
P
D
T
A
-----
L
A
D
A
L
R
I
A
E
R
I
R
M
H
V
S
G
S
--
P
F
T
V
A
H
G
R
E
M
L
N
V
T
I
S
I
G
-
V
S
A
T
A
-
G
E
G
D
T
P
E
A
L
L
K
R
-
A
D
E
G
V
Y
Q
A
K
A
S
G
R
N
A
V
V
G
K
---
1
PsiBlast_PDB
87.26
43%
-89
- C5 -
1W25
4
PLED_CAUCN
A:
[12-449]
-----------
A
N
V
R
L
L
E
A
K
L
T
A
E
Y
Y
E
V
S
T
A
M
D
G
P
T
A
L
A
M
A
A
R
D
L
P
D
I
I
L
L
D
V
M
M
P
G
M
D
G
F
T
V
C
R
K
L
K
D
D
P
T
T
R
H
I
P
V
V
L
I
T
A
L
D
G
R
G
D
R
I
Q
G
L
E
S
G
A
S
D
F
L
T
K
P
I
D
D
V
M
L
F
A
R
V
R
S
L
T
R
F
K
L
V
I
D
E
L
R
Q
R
E
A
S
G
R
R
M
G
V
I
A
G
A
A
A
R
L
D
G
----
L
G
G
R
V
L
I
V
D
D
N
E
R
Q
A
Q
R
V
A
A
E
L
G
V
E
H
R
P
-
V
-
I
E
S
D
P
-
E
K
A
K
I
S
A
G
G
P
V
D
L
V
I
V
N
A
A
A
K
N
F
D
G
L
R
F
T
A
A
L
R
S
E
E
R
T
R
Q
L
P
V
L
A
M
V
D
P
D
D
R
G
R
M
V
K
--
A
L
E
I
G
V
N
D
I
L
S
R
P
I
D
P
Q
E
L
S
A
R
V
K
T
Q
I
Q
---------------
R
K
R
Y
T
D
Y
L
R
N
N
L
D
H
S
L
E
L
A
V
T
D
Q
L
T
G
L
H
N
R
R
Y
M
T
G
Q
L
D
S
L
V
K
R
A
T
L
G
G
D
P
V
----
S
A
L
L
I
D
I
D
F
F
K
K
I
N
D
T
F
G
H
D
I
G
D
E
V
L
R
E
F
A
L
R
L
A
S
N
V
-
R
A
I
D
L
P
C
R
Y
G
G
E
E
F
V
V
I
M
P
D
T
A
-----
L
A
D
A
L
R
I
A
E
R
I
R
M
H
V
S
G
S
--
P
F
T
V
A
H
G
R
E
M
L
N
V
T
I
S
I
G
-
V
S
A
T
A
-
G
E
G
D
T
P
E
A
L
L
K
R
-
A
D
E
G
V
Y
Q
A
K
A
S
G
R
N
A
V
V
G
K
---
96
Fugue
86.88
42%
-88
- C5 -
1W25
4
PLED_CAUCN
A:
[1-454]
S
A
R
I
L
V
V
D
D
I
E
A
N
V
R
L
L
E
A
K
L
T
A
E
Y
Y
E
V
S
T
A
M
D
G
P
T
A
L
A
M
A
A
R
D
L
P
D
I
I
L
L
D
V
M
M
P
G
M
D
G
F
T
V
C
R
K
L
K
D
D
P
T
T
R
H
I
P
V
V
L
I
T
A
L
D
G
R
G
D
R
I
Q
G
L
E
S
G
A
S
D
F
L
T
K
P
I
D
D
V
M
L
F
A
R
V
R
S
L
T
R
F
K
L
V
I
D
E
L
R
Q
R
E
A
S
G
R
R
---
M
G
V
I
A
G
-
A
A
A
R
L
D
G
L
G
G
R
V
L
I
V
D
D
N
E
R
Q
A
Q
R
V
A
A
E
L
G
V
E
H
---
R
P
V
I
E
S
D
P
E
K
A
K
I
S
A
G
G
P
V
D
L
V
I
V
N
A
A
A
K
N
F
D
G
L
R
F
T
A
A
L
R
S
E
E
R
T
R
Q
L
P
V
L
A
M
V
D
P
D
D
R
G
R
M
V
K
--
A
L
E
I
G
V
N
D
I
L
S
R
P
I
D
P
Q
E
L
S
A
R
V
K
T
Q
I
Q
---------------
R
K
R
Y
T
D
Y
L
R
N
N
L
D
H
S
L
E
L
A
V
T
D
Q
L
T
G
L
H
N
R
R
Y
M
T
G
Q
L
D
S
L
V
K
R
A
T
L
G
G
D
P
V
----
S
A
L
L
I
D
I
D
F
F
K
K
I
N
D
T
F
G
H
D
I
G
D
E
V
L
R
E
F
A
L
R
L
A
S
N
V
-
R
A
I
D
L
P
C
R
Y
G
G
E
E
F
V
V
I
M
P
D
T
A
-----
L
A
D
A
L
R
I
A
E
R
I
R
M
H
V
S
G
S
--
P
F
T
V
A
H
G
R
E
M
L
N
V
T
I
S
I
G
V
S
A
T
A
G
-
E
G
-
D
T
P
E
A
L
L
K
R
-
A
D
E
G
V
Y
Q
A
K
A
S
G
R
N
A
V
V
G
K
A
AH
24
PsiBlast_CBE
75.00
33%
-99
- C6 -
3BRE
3
?
B:
[21-334]
--------------------------------------------------------------------------------------------------------------------------------------------------------------
V
L
L
V
D
D
Q
A
M
I
G
E
A
V
R
R
S
L
A
S
E
A
G
I
D
F
H
F
C
S
D
P
Q
Q
A
V
A
V
A
N
Q
I
K
P
T
V
I
L
Q
D
L
V
M
P
G
V
D
G
L
T
L
L
A
A
Y
R
G
N
P
A
T
R
D
I
P
I
I
V
L
S
T
K
E
E
P
T
V
K
S
A
--
A
F
A
A
G
A
N
D
Y
L
V
K
L
P
D
A
I
E
L
V
A
R
I
R
Y
H
S
R
S
Y
I
A
L
Q
Q
R
D
E
A
Y
R
A
L
R
E
S
Q
Q
Q
L
L
E
T
N
L
V
L
Q
R
L
M
N
-
S
D
G
L
T
G
L
S
N
R
R
H
F
D
E
Y
L
E
M
E
W
R
R
S
L
R
E
Q
S
Q
L
----
S
L
L
M
I
D
V
D
Y
F
K
S
Y
N
D
T
F
G
H
V
A
G
D
E
A
L
R
Q
V
A
G
A
I
R
E
G
C
S
R
S
S
D
L
A
A
R
Y
G
G
E
E
F
A
M
V
L
P
G
T
S
-----
P
G
G
A
R
L
L
A
E
K
V
R
R
T
V
E
S
L
--
Q
I
S
H
D
Q
P
R
P
G
S
H
L
T
V
S
I
G
V
S
T
L
V
P
-
G
G
G
G
Q
T
F
R
V
L
I
E
M
A
D
Q
A
L
Y
Q
A
K
N
N
G
R
N
Q
V
G
L
M
---
4
PsiBlast_PDB
72.21
33%
-99
- C6 -
3BRE
3
?
A:
[21-334]
--------------------------------------------------------------------------------------------------------------------------------------------------------------
V
L
L
V
D
D
Q
A
M
I
G
E
A
V
R
R
S
L
A
S
E
A
G
I
D
F
H
F
C
S
D
P
Q
Q
A
V
A
V
A
N
Q
I
K
P
T
V
I
L
Q
D
L
V
M
P
G
V
D
G
L
T
L
L
A
A
Y
R
G
N
P
A
T
R
D
I
P
I
I
V
L
S
T
K
E
E
P
T
V
K
S
A
--
A
F
A
A
G
A
N
D
Y
L
V
K
L
P
D
A
I
E
L
V
A
R
I
R
Y
H
S
R
S
Y
I
A
L
Q
Q
R
D
E
A
Y
R
A
L
R
E
S
Q
Q
Q
L
L
E
T
N
L
V
L
Q
R
L
M
N
-
S
D
G
L
T
G
L
S
N
R
R
H
F
D
E
Y
L
E
M
E
W
R
R
S
L
R
E
Q
S
Q
L
----
S
L
L
M
I
D
V
D
Y
F
K
S
Y
N
D
T
F
G
H
V
A
G
D
E
A
L
R
Q
V
A
G
A
I
R
E
G
C
S
R
S
S
D
L
A
A
R
Y
G
G
E
E
F
A
M
V
L
P
G
T
S
-----
P
G
G
A
R
L
L
A
E
K
V
R
R
T
V
E
S
L
--
Q
I
S
H
D
Q
P
R
P
G
S
H
L
T
V
S
I
G
V
S
T
L
V
P
-
G
G
G
G
Q
T
F
R
V
L
I
E
M
A
D
Q
A
L
Y
Q
A
K
N
N
G
R
N
Q
V
G
L
M
---
5
PsiBlast_PDB
70.84
34%
-102
- C6 -
3I5A
3
?
A:
[19-334]
--------------------------------------------------------------------------------------------------------------------------------------------------------------
V
L
L
V
D
D
Q
A
M
I
G
E
A
V
R
R
G
L
A
G
H
E
S
I
D
F
H
F
C
A
D
P
H
Q
A
I
A
Q
A
V
Q
I
K
P
T
V
I
L
Q
D
L
V
M
P
G
L
D
G
L
T
L
V
R
E
Y
R
S
N
P
L
T
R
D
I
P
I
I
V
L
S
T
--
K
E
D
P
L
I
K
S
A
A
F
A
A
G
A
N
D
Y
L
V
K
L
P
D
N
I
E
L
V
A
R
I
R
Y
H
S
R
S
Y
M
T
L
L
Q
R
D
E
A
Y
R
A
L
R
V
S
Q
Q
Q
L
L
D
T
N
L
V
L
Q
R
L
M
N
-
S
D
G
L
T
G
L
S
N
R
R
H
F
D
E
Y
L
E
L
E
W
R
R
A
T
R
D
Q
A
Q
L
----
S
L
L
M
I
D
V
D
Y
F
K
A
Y
N
D
N
F
G
H
L
E
G
D
E
A
L
R
Q
V
A
K
A
I
R
N
S
C
S
R
P
S
D
L
P
A
R
Y
G
G
E
E
F
A
M
V
L
P
N
T
S
-----
P
G
G
A
R
L
L
A
E
K
L
R
Q
S
V
A
G
M
NI
P
H
I
A
P
V
P
G
S
S
--
L
T
V
S
I
G
V
A
T
V
T
P
-
Q
V
G
Q
H
S
R
Q
L
I
L
D
-
A
D
K
G
L
Y
L
A
K
N
N
G
R
N
Q
V
A
A
G
---
78
HHSearch
56.68
38%
-102
* C6 *
3IGN
2
?
A:
[6-169]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
L
S
M
T
D
R
L
T
G
L
L
N
R
G
T
W
E
N
L
V
D
A
E
Y
E
R
F
R
R
Y
G
Q
A
T
----
S
L
V
M
F
D
I
D
H
F
K
P
V
N
D
T
Y
G
H
L
A
G
D
E
V
I
R
H
T
A
D
V
T
R
N
N
I
-
R
Q
S
D
S
A
G
R
Y
G
G
E
E
F
G
I
I
L
P
E
T
D
-----
A
E
S
A
R
V
I
C
E
R
I
R
E
A
I
E
K
S
--
T
V
S
T
S
--
A
G
D
I
Q
Y
T
V
S
M
G
I
A
Q
L
T
E
--
T
P
E
N
Y
M
Q
W
M
Q
K
-
A
D
E
A
L
Y
K
A
K
E
S
G
R
N
K
V
V
V
S
---
80
HHSearch
56.07
39%
-95
- C6 -
3I5C
5
GCN4_YEAST
A:
[24-196]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
R
L
K
K
L
V
N
S
D
G
L
T
G
L
S
N
R
R
H
F
D
E
Y
L
E
M
E
W
R
R
S
L
R
E
Q
S
Q
L
----
S
L
L
M
I
D
V
D
Y
F
K
S
Y
N
D
T
F
G
H
V
A
G
D
E
A
L
R
Q
V
A
G
A
I
R
E
G
C
S
R
S
S
D
L
A
A
R
Y
G
G
E
E
F
A
M
V
L
P
G
T
S
-----
P
G
G
A
R
L
L
A
E
K
V
R
R
T
V
E
S
L
--
Q
I
S
H
D
Q
P
R
P
G
S
H
L
T
V
S
I
G
V
S
T
L
V
P
G
G
G
G
Q
T
F
R
V
L
I
E
M
-
A
D
Q
A
L
Y
Q
A
K
N
N
G
R
N
Q
V
G
L
M
---
12
PsiBlast_PDB
55.86
33%
-110
- C6 -
4RNH
-
?
A:
[21-182]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
A
Y
Y
D
A
L
T
H
L
P
N
R
T
L
F
Q
D
R
L
H
T
A
L
Q
Q
A
E
R
N
G
Q
W
V
----
V
L
M
F
L
D
L
D
R
F
------
L
G
H
A
A
G
D
R
M
L
Q
E
V
A
T
R
L
S
A
C
V
-
S
Q
D
D
T
V
A
R
M
G
G
D
E
F
T
L
L
L
P
S
Q
G
D
R
E
I
A
L
K
R
A
I
Q
V
A
E
L
I
L
G
R
L
A
-
R
--
P
F
T
L
E
G
R
E
F
F
--
V
T
A
S
I
G
V
A
-
L
S
P
-
Q
D
G
A
E
L
S
L
L
M
K
N
-
A
D
T
A
M
Y
H
A
K
E
M
G
K
N
N
F
Q
F
Y
---
81
HHSearch
54.54
33%
-104
- C6 -
3TVK
5
YDEH_ECOLI
A:
[4-162]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
N
M
D
V
L
T
G
L
P
G
R
R
V
L
D
E
S
F
D
H
Q
L
R
N
A
--
E
P
L
N
L
----
Y
L
M
L
L
D
I
D
R
F
K
L
V
N
D
T
Y
G
H
L
I
G
D
V
V
L
R
T
L
A
T
Y
L
A
S
W
T
-
R
D
Y
E
T
V
Y
R
Y
G
G
E
E
F
I
I
I
V
K
A
A
N
-----
D
E
E
A
C
R
A
G
V
R
I
C
Q
L
V
D
N
H
--
A
I
T
H
S
--
E
G
H
I
N
I
T
V
T
A
G
V
S
R
A
F
P
-
E
--
E
P
L
D
V
V
I
G
R
-
A
D
R
A
M
Y
E
G
K
Q
T
G
R
N
R
C
M
F
I
---
10
PsiBlast_PDB
54.38
35%
-120
- C6 -
4URS
6
?
A:
[27-178]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
A
Y
H
D
P
L
T
G
L
P
N
R
R
Y
F
F
E
L
G
N
R
Y
L
D
L
A
K
R
E
G
K
K
V
----
F
V
L
F
V
D
L
A
G
F
K
A
I
N
D
T
Y
G
H
L
S
G
D
E
V
L
K
T
V
S
K
R
I
L
D
R
V
-
R
R
S
D
V
V
A
R
Y
G
G
D
E
F
T
I
L
L
Y
D
M
K
-----
E
E
Y
L
K
S
L
L
E
R
I
L
S
T
F
-
R
E
--
P
V
R
V
E
N
K
H
L
S
--
V
T
P
N
I
G
V
A
R
F
P
E
--
D
G
E
N
L
E
E
L
L
K
V
-
A
D
M
R
M
Y
K
A
K
E
M
K
V
P
Y
F
S
L
S
---
11
PsiBlast_PDB
54.09
33%
-102
- C6 -
4RNF
-
?
A:
[21-182]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
A
Y
Y
D
A
L
T
H
L
P
N
R
T
L
F
Q
D
R
L
H
T
A
L
Q
Q
A
E
R
N
G
Q
W
V
----
V
L
M
F
L
D
L
D
-----
N
D
S
L
G
H
A
A
G
D
R
M
L
Q
E
V
A
T
R
L
S
A
C
V
-
S
Q
D
D
T
V
A
R
M
G
G
D
E
F
T
L
L
L
P
S
Q
G
D
R
E
I
A
L
K
R
A
I
Q
V
A
E
L
I
L
G
R
L
A
-
R
--
P
F
T
L
E
G
R
E
F
F
--
V
T
A
S
I
G
V
A
-
L
S
P
-
Q
D
G
A
E
L
S
L
L
M
K
N
-
A
D
T
A
M
Y
H
A
K
E
M
G
K
N
N
F
Q
F
Y
---
7
PsiBlast_PDB
54.08
40%
-98
- C6 -
3I5C
5
GCN4_YEAST
A:
[33-193]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
G
L
T
G
L
S
N
R
R
H
F
D
E
Y
L
E
M
E
W
R
R
S
L
R
E
Q
S
Q
L
----
S
L
L
M
I
D
V
D
Y
F
K
S
Y
N
D
T
F
G
H
V
A
G
D
E
A
L
R
Q
V
A
G
A
I
R
E
G
C
S
R
S
S
D
L
A
A
R
Y
G
G
E
E
F
A
M
V
L
P
G
T
S
-----
P
G
G
A
R
L
L
A
E
K
V
R
R
T
V
E
S
L
--
Q
I
S
H
D
Q
P
R
P
G
S
H
L
T
V
S
I
G
V
S
T
L
V
P
-
G
G
G
G
Q
T
F
R
V
L
I
E
M
A
D
Q
A
L
Y
Q
A
K
N
N
G
R
N
Q
V
G
L
M
---
27
PsiBlast_CBE
53.77
35%
-126
- C6 -
4URS
7
?
B:
[27-178]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
A
Y
H
D
P
L
T
G
L
P
N
R
R
Y
F
F
E
L
G
N
R
Y
L
D
L
A
K
R
E
G
K
K
V
----
F
V
L
F
V
D
L
A
G
F
K
A
I
N
D
T
Y
G
H
L
S
G
D
E
V
L
K
T
V
S
K
R
I
L
D
R
V
-
R
R
S
D
V
V
A
R
Y
G
G
D
E
F
T
I
L
L
Y
D
M
K
-----
E
E
Y
L
K
S
L
L
E
R
I
L
S
T
F
-
R
E
--
P
V
R
V
E
N
K
H
L
S
--
V
T
P
N
I
G
V
A
R
F
P
E
--
D
G
E
N
L
E
E
L
L
K
V
-
A
D
M
R
M
Y
K
A
K
E
M
K
V
P
Y
F
S
L
S
---
8
PsiBlast_PDB
53.64
39%
-93
- C6 -
3IGN
2
?
A:
[5-169]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
K
L
S
M
T
D
R
L
T
G
L
L
N
R
G
T
W
E
----
N
L
V
D
A
E
Y
E
R
F
R
R
Y
G
Q
A
T
S
L
V
M
F
D
I
D
H
F
K
P
V
N
D
T
Y
G
H
L
A
G
D
E
V
I
R
H
T
A
D
V
T
R
N
N
I
-
R
Q
S
D
S
A
G
R
Y
G
G
E
E
F
G
I
I
L
P
E
T
D
-----
A
E
S
A
R
V
I
C
E
R
I
R
E
A
I
--
E
--
K
S
T
V
S
T
S
A
G
D
I
Q
Y
T
V
S
M
G
I
A
Q
L
T
E
-
T
P
-
E
N
Y
M
Q
W
M
Q
K
-
A
D
E
A
L
Y
K
A
K
E
S
G
R
N
K
V
V
V
S
---