@TOME V2.3
(Nov 2016)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : Wbm0209: (2015-11-29 )
MDTVYVKYVCQEKPETMEEKLIYYFSQDKCEGNAEMKSLLGGKGANLAEMCNIGIPVPPGFTISTSACKSYYQGNGLSDDLCSTIKEYMTMLENDIGCKFGDSNNPLLVSIRSGSVNSMPGMLDTILNAGLNDTTVIGLAKKSGERFAYDSYCRFIMMYSNVVLQLDHQLFQSIIDNERQKNGAKSLADLNVDVLKRIVCDFKKIVHEKTEKHFPQDIEEQLLSSVNAVFASWQNERAVSYRKIHNIPENLGTAVNVQAMVFGNLNNNSATGVIFTRNPSTGEKKCFGEFLVNAQGEDVVSGVYTPIPINGKQENTMEKLMLSVYQELCEVCKKLEVHYKDMQDIEFTVQGGKLWILQTRSGKRTAEATVRITVDMVNEGTITKEEGILKIDPKIFDNLLHPVLEARGDQKVIGKGLPASPGVASGYVVFSASDAEKAAEQGKKIILVRLETSSEDINGMNAASGIITARGGMTSHAAVVTRGMGKPCICSVNGLHIDKNGNFFSVGDTTVNKGEPITINGGTGEVMLGILPTILPELSQEFKTIINWIDETKMIKVRANADTPKDAKIAKEFGAEGIGLCRTEHMFFASNRIEFIQRLIIADDKTERASALSKLEEMQKSDFKEIFSIMGGREVTIRLLDPPLHEFLPDNQSTIEKIAKSLNKSVESVKNKIVQLSEKNPMLGHRGCRLAISHPEIYSMQTRAILSAVDELKKEKKAEVKPEIMIPFIMSEKEFILICELLKKEAKNFDVNYSIGTMIELPRAALIADKLAKYAEFFSFGTNDLTQTTMGLSRDDSVSFLNSYKENNIFENDPFEVLDVEGVGELIKIAIERGKKTRKEIKLGVCGEHGADPRSIEFLIKSGVSYISCSPYRVPIAKLVAAQKSKCVG
Atome Classification :
(23 SA)
.........10........20........30........40........50........60........70.-.-..-.-...80........90........100.......110.......120.......130.......140..--.--....150.......160.......170.......180.......190.......200.......-210-........220.......230.......240.......250.......260.......270.......280.......290.......300.......310-----------.....------------------....320.......330.......340.......350.......360.......370.......380.......390.......400..--.---..--.--.410-........420.......430.......440.......450.......460..--.....---470.......480.......490.......500.......510.......520....---...530.....--..540.........550.......560.......570.......580.......590-........600.......610.......620.......630.......640.......650-.--.......660.......670.......680.......690.......700.......710.......720.......730------....-------..--..740.......-------750------.......760.......770.......780.......790..-.....800.......810......-.820.......830.....----..840.......850.......860.......870.......880.......
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MD
T
V
Y
V
K
Y
VCQEK
P
E
T
M
E
E
K
L
I
Y
Y
FSQDKCEG
N
A
E
M
K
S
L
LGGKGA
N
L
A
E
M
CNIGIPVPPG
F
T
I
S
T
S
A
C
K
S
Y
Y-Q-GN-G-L
S
D
D
L
C
S
T
I
K
E
Y
M
T
M
L
ENDIGCKFGDSNN
P
L
L
V
S
IRSGSVNSM
P
G
M
L
D
T
I
L
NAGLND
T
T
V
I
G
L
AKKSG--E--RF
A
Y
D
S
Y
C
R
F
I
M
M
Y
S
N
V
V
L
Q
L
D
H
Q
L
F
Q
S
I
I
D
N
E
R
Q
KNG
A
K
S
L
A
DL
N
V
D
V
L
K
R
I
V
C
D
F
K
K
I
V
H
E
K
-
T
-
E
-KHF
P
Q
D
I
E
E
Q
L
L
S
S
V
N
A
V
F
A
S
WQNERA
V
S
Y
R
K
I
HNI
P
E
N
LGT
A
V
N
V
Q
A
M
V
F
GNLNNNSA
T
G
V
I
F
TRNPSTG
E
K
K
C
F
G
E
F
L
VNAQGE
D
V
VSGVYTPIPIN-------------GKQE
N
------------------
T
M
E
K
L
M
L
S
V
Y
Q
E
L
C
E
V
C
K
K
L
E
V
H
Y
KDMQ
D
I
E
F
T
V
QG
G
K
L
W
I
L
QTRSGKRT
A
E
A
T
V
R
I
T
V
D
MVNEGTITKEE
G
I
L
K
I
D
P
K
I
F
D
N
L
L
H
P
V
L
--
E
---AR--G--DQ
K
--
V
IGKGLPASPGVAS
G
Y
V
V
F
SAS
D
A
E
K
A
A
EQG
K
K
I
I
L
V
R
L
ETSSEDINGMNAA
S
--
G
I
I
T
A---RGGM
T
S
H
A
A
V
V
TRGMGK
P
C
I
C
S
VN
G
L
H
IDKNG
N
F
F
SVGDTTVNKG
E
P
I
T
INGGT
G
E
V
---
M
L
G
I
L
P
T
I
L
P
E
--
L
S
Q
--
E
F
K
T
I
I
N
W
IDET
K
M
I
K
V
R
ANADTP
K
D
A
K
I
A
K
E
FGAEGIGLCR
T
E
H
M
F
F
A
S
-
N
-
R
I
E
F
I
Q
R
L
I
IADD
K
T
E
R
A
S
A
L
S
K
L
E
E
M
Q
K
S
D
F
K
E
I
F
S
IMGG
R
E
V
T
I
R
LLDP
P
L
H
E
FLPD
N
--
Q
--
S
T
I
E
K
I
A
K
S
L
N
K
S
V
E
S
V
K
N
K
I
V
QLSEKNPMLGHRG
C
R
L
A
ISHP
E
I
Y
S
M
Q
T
R
A
I
L
S
A
V
D
E
L
K
K
E
K
KAEVKP
E
I
M
I
P
F
IMS-------EK
E
F
-------
I
L
--
I
C
E
L
L
K
K
E
A
KNF-------DVN------YSIG
T
M
IEL
P
R
A
A
L
I
A
D
K
L
A
K
Y
A
E
F
F
SFGTND
L
T
Q
T
TMGLSR-D
D
S
V
S
F
L
N
S
YKENNIFENDP
F
E
V
L
-
D
V
E
G
V
G
E
L
I
K
I
A
I
E
RGKK
T
----
R
K
E
I
K
L
G
V
CGEHGADP
R
S
I
E
F
L
I
K
SGV
S
Y
ISCSPYR
V
P
I
A
K
L
V
A
A
Q
K
SKCVG
2
PsiBlast_PDB
97.28
50%
-85
- C4 -
1KBL
6
PPDK_CLOSY
A:
[2-860]
-------------------
K
W
V
Y
K
F
E
----
E
G
N
A
S
M
R
N
L
L
G
G
K
G
C
N
L
A
E
M
T
I
L
G
M
P
I
P
Q
G
F
T
V
T
T
E
A
C
T
E
Y
Y
N
S
-
G
K
-
Q
-
I
T
Q
E
I
Q
D
Q
I
F
E
A
I
T
W
L
E
E
L
N
G
K
K
F
G
D
T
E
D
P
L
L
V
S
V
R
S
G
A
R
A
S
M
P
G
M
M
D
T
I
L
N
L
G
L
N
D
V
A
V
E
G
F
A
K
K
T
G
--
N
P
-
R
F
A
Y
D
S
Y
R
R
F
I
Q
M
Y
S
D
V
V
M
E
V
P
K
S
H
F
E
K
I
I
D
A
M
K
E
E
K
G
V
H
F
D
T
D
L
T
A
D
D
L
K
E
L
A
E
K
F
K
A
V
Y
K
E
A
-
M
-
N
G
E
E
F
P
Q
E
P
K
D
Q
L
M
G
A
V
K
A
V
F
R
S
W
D
N
P
R
A
I
V
Y
R
R
M
N
D
I
P
G
D
W
G
T
A
V
N
V
Q
T
M
V
F
G
N
K
G
E
T
S
G
T
G
V
A
F
T
R
N
P
S
T
G
E
K
G
I
Y
G
E
Y
L
I
N
A
Q
G
E
D
V
V
A
G
V
R
T
P
Q
P
I
T
------------------------------------
Q
L
E
N
D
M
P
D
C
Y
K
Q
F
M
D
L
A
M
K
L
E
K
H
F
R
D
M
Q
D
M
E
F
T
I
E
E
G
K
L
Y
F
L
Q
T
R
N
G
K
R
T
A
P
A
A
L
Q
I
A
C
D
L
V
D
E
G
M
I
T
E
E
E
A
V
V
R
I
E
A
K
S
L
D
Q
L
L
H
P
T
F
--
N
P
A
-
A
L
--
K
--
A
G
E
--
V
I
G
S
A
L
P
A
S
P
G
A
A
A
G
K
V
Y
F
T
A
D
E
A
K
A
A
H
E
K
G
E
R
V
I
L
V
R
L
E
T
S
P
E
D
I
E
G
M
H
A
A
E
--
G
I
L
T
V
---
R
G
G
M
T
S
H
A
A
V
V
A
R
G
M
G
T
C
C
V
S
G
C
G
E
I
K
I
N
E
E
A
K
T
F
E
L
G
G
H
T
F
A
E
G
D
Y
I
S
L
D
G
S
T
G
K
I
---
Y
K
G
D
I
E
T
Q
E
A
S
--
V
S
G
--
S
F
E
R
I
M
V
W
A
D
K
F
R
T
L
K
V
R
T
N
A
D
T
P
E
D
T
L
N
A
V
K
L
G
A
E
G
I
G
L
C
R
T
E
H
M
F
F
E
A
-
D
-
R
I
M
K
I
R
K
M
I
L
S
D
S
V
E
A
R
E
E
A
L
N
E
L
I
P
F
Q
K
G
D
F
K
A
M
Y
K
A
L
E
G
R
P
M
T
V
R
Y
L
D
P
P
L
H
E
F
V
P
H
T
--
E
--
E
E
Q
A
E
L
A
K
N
M
G
L
T
L
A
E
V
K
A
K
V
D
E
L
H
E
F
N
P
M
M
G
H
R
G
C
R
L
A
V
T
Y
P
E
I
A
K
M
Q
T
R
A
V
M
E
A
A
I
E
V
K
E
E
T
G
I
D
I
V
P
E
I
M
I
P
L
V
G
E
-------
K
K
E
L
K
F
V
K
D
V
V
V
E
--
V
A
E
Q
V
K
K
E
-
K
G
S
-------
D
M
Q
------
Y
H
I
G
T
M
I
E
I
P
R
A
A
L
T
A
D
A
I
A
E
E
A
E
F
F
S
F
G
T
N
D
L
T
Q
M
T
F
G
F
S
R
-
D
D
A
G
K
F
L
D
S
Y
Y
K
A
K
I
Y
E
S
D
P
F
A
R
L
-
D
Q
T
G
V
G
Q
L
V
E
M
A
V
K
K
G
R
Q
T
----
R
P
G
L
K
C
G
I
C
G
E
H
G
G
D
P
S
S
V
E
F
C
H
K
V
G
L
N
Y
V
S
C
S
P
F
R
V
P
I
A
R
L
A
A
A
Q
A
A
L
N
N
-
45
Fugue
97.22
51%
-85
- C4 -
1KBL
6
PPDK_CLOSY
A:
[1-872]
------------------
A
K
W
V
Y
K
----
F
E
E
G
N
A
S
M
R
N
L
L
G
G
K
G
C
N
L
A
E
M
T
I
L
G
M
P
I
P
Q
G
F
T
V
T
T
E
A
C
T
E
Y
Y
-
N
S
G
K
-
Q
-
I
T
Q
E
I
Q
D
Q
I
F
E
A
I
T
W
L
E
E
L
N
G
K
K
F
G
D
T
E
D
P
L
L
V
S
V
R
S
G
A
R
A
S
M
P
G
M
M
D
T
I
L
N
L
G
L
N
D
V
A
V
E
G
F
A
K
K
T
G
---N
P
R
F
A
Y
D
S
Y
R
R
F
I
Q
M
Y
S
D
V
V
M
E
V
P
K
S
H
F
E
K
I
I
D
A
M
K
E
E
K
G
V
H
F
D
T
D
L
T
A
D
D
L
K
E
L
A
E
K
F
K
A
V
Y
K
E
A
-
M
N
G
-
E
E
F
P
Q
E
P
K
D
Q
L
M
G
A
V
K
A
V
F
R
S
W
D
N
P
R
A
I
V
Y
R
R
M
N
D
I
P
G
D
W
G
T
A
V
N
V
Q
T
M
V
F
G
N
K
G
E
T
S
G
T
G
V
A
F
T
R
N
P
S
T
G
E
K
G
I
Y
G
E
Y
L
I
N
A
Q
G
E
D
V
V
A
G
V
R
T
P
Q
P
I
T
Q------------------------------------
L
E
N
D
M
P
D
C
Y
K
Q
F
M
D
L
A
M
K
L
E
K
H
F
R
D
M
Q
D
M
E
F
T
I
E
E
G
K
L
Y
F
L
Q
T
R
N
G
K
R
T
A
P
A
A
L
Q
I
A
C
D
L
V
D
E
G
M
I
T
E
E
E
A
V
V
R
I
E
A
K
S
L
D
Q
L
L
H
P
T
F
--
N
---
P
A
--
A
--
L
K
A
GE
V
I
G
S
A
L
P
A
S
P
G
A
A
A
G
K
V
Y
F
T
A
D
E
A
K
A
A
H
E
K
G
E
R
V
I
L
V
R
L
E
T
S
P
E
D
I
E
G
M
H
A
A
E
--
G
I
L
T
V
---
R
G
G
M
T
S
H
A
A
V
V
A
R
G
M
G
T
C
C
V
S
G
C
G
E
I
K
I
N
E
E
A
K
T
F
E
L
G
G
H
T
F
A
E
G
D
Y
I
S
L
D
G
S
T
G
K
I
---
Y
K
G
D
I
E
T
Q
E
A
-
S
V
S
-
G
--
S
F
E
R
I
M
V
W
A
D
K
F
R
T
L
K
V
R
T
N
A
D
T
P
E
D
T
L
N
A
V
K
L
G
A
E
G
I
G
L
C
R
T
E
H
M
F
F
E
A
-
D
-
R
I
M
K
I
R
K
M
I
L
S
D
S
V
E
A
R
E
E
A
L
N
E
L
I
P
F
Q
K
G
D
F
K
A
M
Y
K
A
L
E
G
R
P
M
T
V
R
Y
L
D
P
P
L
H
E
F
V
P
H
T
--
E
--
E
E
Q
A
E
L
A
K
N
M
G
L
T
L
A
E
V
K
A
K
V
D
E
L
H
E
F
N
P
M
M
G
H
R
G
C
R
L
A
V
T
Y
P
E
I
A
K
M
Q
T
R
A
V
M
E
A
A
I
E
V
K
E
E
T
G
I
D
I
V
P
E
I
M
I
P
L
V
G
E
-------
K
K
E
L
-------
K
F
--
V
K
D
V
V
V
E
V
A
E
Q
V
-------
K
K
E
K
GSD
M
Q
Y
H
I
G
T
M
I
E
I
P
R
A
A
L
T
A
D
A
I
A
E
E
A
E
F
F
S
F
G
T
N
D
L
T
Q
M
T
F
G
F
S
R
-
D
D
A
G
K
F
L
D
S
Y
Y
K
A
K
I
Y
E
S
D
P
F
A
R
L
-
D
Q
T
G
V
G
Q
L
V
E
M
A
V
K
K
G
R
Q
T
----
R
P
G
L
K
C
G
I
C
G
E
H
G
G
D
P
S
S
V
E
F
C
H
K
V
G
L
N
Y
V
S
C
S
P
F
R
V
P
I
A
R
L
A
A
A
Q
A
A
L
N
N
-
3
PsiBlast_PDB
96.60
50%
-86
- C4 -
1KC7
6
PPDK_CLOSY
A:
[2-860]
-------------------
K
W
V
Y
K
F
E
----
E
G
N
A
S
M
R
N
L
L
G
G
K
G
C
N
L
A
E
M
T
I
L
G
M
P
I
P
Q
G
F
T
V
T
T
E
A
C
T
E
Y
Y
N
S
-
G
K
-
Q
-
I
T
Q
E
I
Q
D
Q
I
F
E
A
I
T
W
L
E
E
L
N
G
K
K
F
G
D
T
E
D
P
L
L
V
S
V
R
S
G
A
R
A
S
M
P
G
M
M
D
T
I
L
N
L
G
L
N
D
V
A
V
E
G
F
A
K
K
T
G
--
N
P
-
R
F
A
Y
D
S
Y
R
R
F
I
Q
M
Y
S
D
V
V
M
E
V
P
K
S
H
F
E
K
I
I
D
A
M
K
E
E
K
G
V
H
F
D
T
D
L
T
A
D
D
L
K
E
L
A
E
K
F
K
A
V
Y
K
E
A
-
M
-
N
G
E
E
F
P
Q
E
P
K
D
Q
L
M
G
A
V
K
A
V
F
R
S
W
D
N
P
R
A
I
V
Y
R
R
M
N
D
I
P
G
D
W
G
T
A
V
N
V
Q
T
M
V
F
G
N
K
G
E
T
S
G
T
G
V
A
F
T
R
N
P
S
T
G
E
K
G
I
Y
G
E
Y
L
I
N
A
Q
G
E
D
V
V
A
G
V
R
T
P
Q
P
I
T
------------------------------------
Q
L
E
N
D
M
P
D
C
Y
K
Q
F
M
D
L
A
M
K
L
E
K
H
F
R
D
M
Q
D
M
E
F
T
I
E
E
G
K
L
Y
F
L
Q
T
R
N
G
K
R
T
A
P
A
A
L
Q
I
A
C
D
L
V
D
E
G
M
I
T
E
E
E
A
V
V
R
I
E
A
K
S
L
D
Q
L
L
H
P
T
F
--
N
P
A
-
A
L
--
K
--
A
G
E
--
V
I
G
S
A
L
P
A
S
P
G
A
A
A
G
K
V
Y
F
T
A
D
E
A
K
A
A
H
E
K
G
E
R
V
I
L
V
R
L
E
T
S
P
E
D
I
E
G
M
H
A
A
E
--
G
I
L
T
V
---
R
G
G
M
T
S
H
A
A
V
V
A
R
G
M
G
T
C
C
V
S
G
C
G
E
I
K
I
N
E
E
A
K
T
F
E
L
G
G
H
T
F
A
E
G
D
Y
I
S
L
D
G
S
T
G
K
I
---
Y
K
G
D
I
E
T
Q
E
A
S
--
V
S
G
--
S
F
E
R
I
M
V
W
A
D
K
F
R
T
L
K
V
R
T
N
A
D
T
P
E
D
T
L
N
A
V
K
L
G
A
E
G
I
G
L
C
R
T
E
H
M
F
F
E
A
-
D
-
R
I
M
K
I
R
K
M
I
L
S
D
S
V
E
A
R
E
E
A
L
N
E
L
I
P
F
Q
K
G
D
F
K
A
M
Y
K
A
L
E
G
R
P
M
T
V
R
Y
L
D
P
P
L
H
E
F
V
P
H
T
--
E
--
E
E
Q
A
E
L
A
K
N
M
G
L
T
L
A
E
V
K
A
K
V
D
E
L
H
E
F
N
P
M
M
G
H
R
G
C
R
L
A
V
T
Y
P
E
I
A
K
M
Q
T
R
A
V
M
E
A
A
I
E
V
K
E
E
T
G
I
D
I
V
P
E
I
M
I
P
L
V
G
E
-------
K
K
E
L
K
F
V
K
D
V
V
V
E
--
V
A
E
Q
V
K
K
E
-
K
G
S
-------
D
M
Q
------
Y
H
I
G
T
M
I
E
I
P
R
A
A
L
T
A
D
A
I
A
E
E
A
E
F
F
S
F
G
T
N
D
L
T
Q
M
T
F
G
F
S
R
-
D
D
A
G
K
F
L
D
S
Y
Y
K
A
K
I
Y
E
S
D
P
F
A
R
L
-
D
Q
T
G
V
G
Q
L
V
E
M
A
V
K
K
G
R
Q
T
----
R
P
G
L
K
C
G
I
C
G
E
H
G
G
D
P
S
S
V
E
F
C
H
K
V
G
L
N
Y
V
S
C
S
P
F
R
V
P
I
A
R
L
A
A
A
Q
A
A
L
N
N
-
5
PsiBlast_PDB
95.80
50%
-81
- C4 -
1DIK
3
PPDK_CLOSY
A:
[3-861]
-------------------
K
W
V
Y
K
F
E
----
E
G
N
A
S
M
R
N
L
L
G
G
K
G
C
N
L
A
E
M
T
I
L
G
M
P
I
P
Q
G
F
T
V
T
T
E
A
C
T
E
Y
Y
N
S
-
G
K
-
Q
-
I
T
Q
E
I
Q
D
Q
I
F
E
A
I
T
W
L
E
E
L
N
G
K
K
F
G
D
T
E
D
P
L
L
V
S
V
R
S
A
A
R
A
S
M
P
G
M
M
D
T
I
L
N
L
G
L
N
D
V
A
V
E
G
F
A
K
K
T
G
--
N
P
-
R
F
A
Y
D
S
Y
R
R
F
I
Q
M
Y
S
D
V
V
M
E
V
P
K
S
H
F
E
K
I
I
D
A
M
K
E
E
K
G
V
H
F
D
T
D
L
T
A
D
D
L
K
E
L
A
E
K
F
K
A
V
Y
K
E
A
-
M
-
N
G
E
E
F
P
Q
E
P
K
D
Q
L
M
G
A
V
K
A
V
F
R
S
W
D
N
P
R
A
I
V
Y
R
R
M
N
D
I
P
G
D
W
G
T
A
V
N
V
Q
T
M
V
F
G
N
K
G
E
T
S
G
T
G
V
A
F
T
R
N
P
S
T
G
E
K
G
I
Y
G
E
Y
L
I
N
A
Q
G
E
D
V
V
A
G
V
R
T
P
Q
P
I
T
------------------------------------
Q
L
E
N
D
M
P
D
C
Y
K
Q
F
M
D
L
A
M
K
L
E
K
H
F
R
D
M
Q
D
M
E
F
T
I
E
E
G
K
L
Y
F
L
Q
T
R
N
G
K
R
T
A
P
A
A
L
Q
I
A
C
D
L
V
D
E
G
M
I
T
E
E
E
A
V
V
R
I
E
A
K
S
L
D
Q
L
L
H
P
T
F
--
N
P
A
-
A
L
--
K
--
A
G
E
--
V
I
G
S
A
L
P
A
S
P
G
A
A
A
G
K
V
Y
F
T
A
D
E
A
K
A
A
H
E
K
G
E
R
V
I
L
V
R
L
E
T
S
P
E
D
I
E
G
M
H
A
A
E
--
G
I
L
T
V
---
R
G
G
M
T
S
H
A
A
V
V
A
R
G
M
G
T
C
C
V
S
G
C
G
E
I
K
I
N
E
E
A
K
T
F
E
L
G
G
H
T
F
A
E
G
D
Y
I
S
L
D
G
S
T
G
K
I
-------
I
E
T
Q
E
A
S
--
V
S
G
--
S
F
E
R
I
M
V
W
A
D
K
F
R
T
L
K
V
R
T
N
A
D
T
P
E
D
T
L
N
A
V
K
L
G
A
E
G
I
G
L
C
R
T
E
H
M
F
F
E
A
-
D
-
R
I
M
K
I
R
K
M
I
L
S
D
S
V
E
A
R
E
E
A
L
N
E
L
I
P
F
Q
K
G
D
F
K
A
M
Y
K
A
L
E
G
R
P
M
T
V
R
Y
L
D
P
P
L
H
E
F
V
P
H
T
--
E
--
E
E
Q
A
E
L
A
K
N
M
G
L
T
L
A
E
V
K
A
K
V
D
E
L
H
E
F
N
P
M
M
G
H
R
G
C
R
L
A
V
T
Y
P
E
I
A
K
M
Q
T
R
A
V
M
E
A
A
I
E
V
K
E
E
T
G
I
D
I
V
P
E
I
M
I
P
L
V
G
E
-------
K
K
E
L
K
F
V
K
D
V
V
V
E
--
V
A
E
Q
V
K
K
E
-
K
G
S
-------
D
M
Q
------
Y
H
I
G
T
M
I
E
I
P
R
A
A
L
T
A
D
A
I
A
E
E
A
E
F
F
S
F
G
T
N
D
L
T
Q
M
T
F
G
F
S
R
-
D
D
A
G
K
F
L
D
S
Y
Y
K
A
K
I
Y
E
S
D
P
F
A
R
L
-
D
Q
T
G
V
G
Q
L
V
E
M
A
V
K
K
G
R
Q
T
----
R
P
G
L
K
C
G
I
C
G
E
H
G
G
D
P
S
S
V
E
F
C
H
K
V
G
L
N
Y
V
S
C
S
P
F
R
V
P
I
A
R
L
A
A
A
Q
A
A
L
N
N
K
7
PsiBlast_PDB
95.72
50%
-92
- C4 -
2R82
2
PPDK_CLOSY
A:
[3-861]
-------------------
K
W
V
Y
K
F
E
----
E
G
N
A
S
M
R
N
L
L
G
G
K
G
C
N
L
A
E
M
T
I
L
G
M
P
I
P
Q
G
F
T
V
T
T
E
A
C
T
E
Y
Y
N
S
-
G
K
-
Q
-
I
T
Q
E
I
Q
D
Q
I
F
E
A
I
T
W
L
E
E
L
N
G
K
K
F
G
D
T
E
D
P
L
L
V
S
V
R
S
G
A
R
A
S
M
P
G
M
M
D
T
I
L
N
L
G
L
N
D
V
A
V
E
G
F
A
K
K
T
G
--
N
P
-
R
F
A
Y
D
S
Y
R
R
F
I
Q
M
Y
S
D
V
V
M
E
V
P
K
S
H
F
E
K
I
I
D
A
M
K
E
E
K
G
V
H
F
D
T
D
L
T
A
D
D
L
K
E
L
A
E
K
F
K
A
V
Y
K
E
A
-
M
-
N
G
E
E
F
P
Q
E
P
K
D
Q
L
M
G
A
V
K
A
V
F
R
S
W
D
N
P
E
A
I
V
Y
R
R
M
N
D
I
P
G
D
W
G
T
A
V
N
V
Q
T
M
V
F
G
N
K
G
E
T
S
G
T
G
V
A
F
T
R
N
P
D
T
G
E
K
G
I
Y
G
R
Y
L
I
N
A
Q
G
E
D
V
V
A
G
V
R
T
P
Q
P
I
T
------------------------------------
Q
L
E
N
D
M
P
D
C
Y
K
Q
F
M
D
L
A
M
K
L
E
K
H
F
R
D
M
Q
D
M
E
F
T
I
E
E
G
K
L
Y
F
L
Q
T
R
N
G
K
R
T
A
P
A
A
L
Q
I
A
C
D
L
V
D
E
G
M
I
T
E
E
E
A
V
V
R
I
E
A
K
S
L
D
Q
L
L
H
P
T
F
--
N
P
A
-
A
L
--
K
--
A
G
E
--
V
I
G
S
A
L
P
A
S
P
G
A
A
A
G
K
V
Y
F
T
A
D
E
A
K
A
A
H
E
K
G
E
R
V
I
L
V
R
L
E
T
S
P
E
D
I
E
G
M
H
A
A
E
--
G
I
L
T
V
---
R
G
G
M
T
S
H
A
A
V
V
A
R
G
M
G
T
C
C
V
S
G
C
G
E
I
K
I
N
E
E
A
K
T
F
E
L
G
G
H
T
F
A
E
G
D
Y
I
S
L
D
G
S
T
G
K
I
---
Y
K
G
D
I
E
T
Q
E
A
S
--
V
S
G
--
S
F
E
R
I
M
V
W
A
D
K
F
R
T
L
K
V
R
T
N
A
D
T
P
E
D
T
L
N
A
V
K
L
G
A
E
G
I
G
L
C
R
T
E
H
M
F
F
E
A
-
D
-
R
I
M
K
I
R
K
M
I
L
S
D
S
V
E
A
R
E
E
A
L
N
E
L
I
P
F
Q
K
G
D
F
K
A
M
Y
K
A
L
E
G
R
P
M
T
V
R
Y
L
D
P
P
L
H
E
F
V
P
H
T
--
E
--
E
E
Q
A
E
L
A
K
N
M
G
L
T
L
A
E
V
K
A
K
V
D
E
L
H
E
F
N
P
M
M
G
H
R
G
C
R
L
A
V
T
Y
P
E
I
A
K
M
Q
T
R
A
V
M
E
A
A
I
E
V
K
E
E
T
G
I
D
I
V
P
E
I
M
I
P
L
V
G
E
-------
K
K
E
L
K
F
V
K
D
V
V
V
E
--
V
A
E
Q
V
K
K
E
-
K
G
S
-------
D
M
Q
------
Y
H
I
G
T
M
I
E
I
P
R
A
A
L
T
A
D
A
I
A
E
E
A
E
F
F
S
F
G
T
N
D
L
T
Q
M
T
F
G
F
S
R
-
D
D
A
G
K
F
L
D
S
Y
Y
K
A
K
I
Y
E
S
D
P
F
A
R
L
-
D
Q
T
G
V
G
Q
L
V
E
M
A
V
K
K
G
R
Q
T
----
R
P
G
L
K
C
G
I
C
G
E
H
G
G
D
P
S
S
V
E
F
C
H
K
V
G
L
N
Y
V
S
C
S
P
F
R
V
P
I
A
R
L
A
A
A
Q
A
A
L
N
N
-
1
PsiBlast_PDB
95.68
50%
-87
- C4 -
2X0S
-
?
A:
[3-894]
------------------
K
K
W
V
Y
Y
F
G
G
G
N
A
D
G
N
K
N
M
K
E
L
L
G
G
K
G
A
N
L
A
E
M
V
N
L
G
I
P
V
P
P
G
F
T
I
T
T
E
A
C
K
T
Y
Q
-
E
-
T
E
-
T
-
I
P
Q
E
V
A
D
Q
V
R
E
N
V
S
R
V
E
K
E
M
G
A
K
F
G
D
P
A
N
P
L
L
F
S
V
R
S
G
A
A
A
S
M
----
D
T
V
L
N
L
G
L
N
K
V
T
V
D
A
W
V
R
R
A
P
RL
E
--
R
F
V
Y
D
S
Y
R
R
F
I
T
M
Y
A
D
I
V
M
Q
V
G
R
E
D
F
E
E
A
L
S
R
M
K
E
R
R
G
T
K
F
D
T
D
L
T
A
S
D
L
K
E
L
C
D
G
Y
L
E
L
F
E
L
K
-
T
-
G
-
C
S
F
P
Q
D
P
V
M
Q
L
F
A
A
I
K
A
V
F
R
S
W
G
N
P
R
A
T
I
Y
R
R
M
N
N
I
T
G
L
L
G
T
A
V
N
V
Q
A
M
V
F
G
N
I
N
D
R
S
A
T
G
V
A
F
S
R
S
P
S
T
G
E
N
F
F
F
G
E
Y
L
V
N
A
Q
G
E
D
V
V
A
G
I
R
T
P
Q
Q
I
N
H
S
L
S
L
R
W
A
K
A
H
GV
G
E
E
E
R
R
K
RYP-------------
S
M
E
E
A
M
P
E
N
Y
R
L
L
C
D
V
R
K
R
L
E
N
H
Y
R
D
M
Q
D
L
E
F
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V
Q
D
G
R
L
W
L
L
Q
C
R
N
G
K
R
T
I
H
A
A
V
R
I
A
I
D
M
V
N
E
G
L
I
S
R
E
E
A
V
L
R
I
D
P
Y
Q
V
D
H
L
M
H
P
N
L
--
E
PG-
A
E
--
K
--
A
N
K
--
P
I
G
R
G
L
A
A
S
P
G
A
A
V
G
Q
V
V
F
D
A
E
S
A
K
E
W
S
G
R
G
K
K
V
I
M
V
R
L
E
T
S
P
E
D
L
A
G
M
D
A
A
C
--
G
I
L
T
A
---
R
G
G
M
T
S
H
A
A
V
V
A
R
G
M
G
K
C
C
V
S
G
C
G
D
M
V
I
--
R
G
K
S
F
K
L
N
G
S
V
F
R
E
G
D
Y
I
T
I
D
G
S
K
G
L
I
---
Y
A
G
K
L
K
L
R
S
P
D
--
L
K
G
--
S
F
Q
T
I
L
Q
W
C
Q
E
M
K
R
L
G
V
R
T
N
A
D
T
P
A
D
A
A
K
A
R
S
F
G
A
E
G
V
G
L
C
R
T
E
H
M
F
F
E
G
-
S
-
R
I
N
F
I
R
E
M
I
L
A
D
S
A
S
G
R
K
A
A
L
D
K
L
L
P
I
Q
R
A
D
F
V
G
I
L
R
A
M
R
G
L
P
V
T
I
R
L
L
D
P
P
L
H
E
F
V
P
H
D
--
A
--
A
A
Q
F
E
L
A
Q
K
L
G
M
P
A
E
K
V
R
N
R
V
N
A
L
H
E
L
N
P
M
L
G
H
R
G
C
R
L
G
I
T
Y
P
E
I
Y
N
M
Q
V
R
A
I
I
E
A
A
I
A
V
-
S
E
E
G
S
S
V
I
P
E
I
M
V
P
L
V
G
K
-------
K
E
E
L
-------
S
L
--
I
R
E
E
V
V
K
T
A
E
A
V
I
T
K
S
G
K
-
R
V
H
------
Y
T
V
G
T
M
I
E
V
P
R
A
A
V
T
A
D
S
I
A
Q
K
A
D
F
F
S
F
G
T
N
D
L
T
Q
M
G
C
G
F
S
R
-
D
D
A
G
P
F
L
R
H
Y
G
N
L
G
I
Y
A
Q
D
P
F
Q
S
I
-
D
Q
E
G
I
G
E
L
V
R
I
A
V
T
K
G
R
R
V
----
K
P
M
L
K
M
G
I
C
G
E
H
G
G
D
P
A
T
I
G
F
C
H
K
V
G
L
D
Y
V
S
C
S
P
F
R
V
P
V
A
I
V
A
A
A
H
A
S
I
K
D
R
4
PsiBlast_PDB
95.55
50%
-81
- C4 -
1GGO
2
PPDK_CLOSY
A:
[2-860]
-------------------
K
W
V
Y
K
F
E
----
E
G
N
A
S
M
R
N
L
L
G
G
K
G
C
N
L
A
E
M
T
I
L
G
M
P
I
P
Q
G
F
T
V
T
T
E
A
C
T
E
Y
Y
N
S
-
G
K
-
Q
-
I
T
Q
E
I
Q
D
Q
I
F
E
A
I
T
W
L
E
E
L
N
G
K
K
F
G
D
T
E
D
P
L
L
V
S
V
R
S
G
A
R
A
S
M
P
G
M
M
D
T
I
L
N
L
G
L
N
D
V
A
V
E
G
F
A
K
K
T
G
--
N
P
-
R
F
A
Y
D
S
Y
R
R
F
I
Q
M
Y
S
D
V
V
M
E
V
P
K
S
H
F
E
K
I
I
D
A
M
K
E
E
K
G
V
H
F
D
T
D
L
T
A
D
D
L
K
E
L
A
E
K
F
K
A
V
Y
K
E
A
-
M
-
N
G
E
E
F
P
Q
E
P
K
D
Q
L
M
G
A
V
K
A
V
F
R
S
W
D
N
P
R
A
I
V
Y
R
R
M
N
D
I
P
G
D
W
G
T
A
V
N
V
Q
T
M
V
F
G
N
K
G
E
T
S
G
T
G
V
A
F
T
R
N
P
S
T
G
E
K
G
I
Y
G
E
Y
L
I
N
A
Q
G
E
D
V
V
A
G
V
R
T
P
Q
P
I
T
------------------------------------
Q
L
E
N
D
M
P
D
C
Y
K
Q
F
M
D
L
A
M
K
L
E
K
H
F
R
D
M
Q
D
M
E
F
T
I
E
E
G
K
L
Y
F
L
Q
T
R
N
G
K
R
T
A
P
A
A
L
Q
I
A
C
D
L
V
D
E
G
M
I
T
E
E
E
A
V
V
R
I
E
A
K
S
L
D
Q
L
L
H
P
T
F
--
N
P
A
-
A
L
--
K
--
A
G
E
--
V
I
G
S
A
L
P
A
S
P
G
A
A
A
G
K
V
Y
F
T
A
D
E
A
K
A
A
H
E
K
G
E
R
V
I
L
V
R
L
E
T
S
P
E
D
I
E
G
M
H
A
A
E
--
G
I
L
T
V
---
R
G
G
M
A
S
H
A
A
V
V
A
R
G
M
G
T
C
C
V
S
G
C
G
E
I
K
I
N
E
E
A
K
T
F
E
L
G
G
H
T
F
A
E
G
D
Y
I
S
L
D
G
S
T
G
K
I
-------
I
E
T
Q
E
A
S
--
V
S
G
--
S
F
E
R
I
M
V
W
A
D
K
F
R
T
L
K
V
R
T
N
A
D
T
P
E
D
T
L
N
A
V
K
L
G
A
E
G
I
G
L
C
R
T
E
H
M
F
F
E
A
-
D
-
R
I
M
K
I
R
K
M
I
L
S
D
S
V
E
A
R
E
E
A
L
N
E
L
I
P
F
Q
K
G
D
F
K
A
M
Y
K
A
L
E
G
R
P
M
T
V
R
Y
L
D
P
P
L
H
E
F
V
P
H
T
--
E
--
E
E
Q
A
E
L
A
K
N
M
G
L
T
L
A
E
V
K
A
K
V
D
E
L
H
E
F
N
P
M
M
G
H
R
G
C
R
L
A
V
T
Y
P
E
I
A
K
M
Q
T
R
A
V
M
E
A
A
I
E
V
K
E
E
T
G
I
D
I
V
P
E
I
M
I
P
L
V
G
E
-------
K
K
E
L
K
F
V
K
D
V
V
V
E
--
V
A
E
Q
V
K
K
E
-
K
G
S
-------
D
M
Q
------
Y
H
I
G
T
M
I
E
I
P
R
A
A
L
T
A
D
A
I
A
E
E
A
E
F
F
S
F
G
T
N
D
L
T
Q
M
T
F
G
F
S
R
-
D
D
A
G
K
F
L
D
S
Y
Y
K
A
K
I
Y
E
S
D
P
F
A
R
L
-
D
Q
T
G
V
G
Q
L
V
E
M
A
V
K
K
G
R
Q
T
----
R
P
G
L
K
C
G
I
C
G
E
H
G
G
D
P
S
S
V
E
F
C
H
K
V
G
L
N
Y
V
S
C
S
P
F
R
V
P
I
A
R
L
A
A
A
Q
A
A
L
N
N
K
8
PsiBlast_PDB
95.50
50%
-89
- C4 -
1VBG
4
PPDK1_MAIZE
A:
[3-873]
------------------
K
K
R
V
F
H
F
G
K
G
K
S
E
G
N
K
T
M
K
E
L
L
G
G
K
G
A
N
L
A
E
M
A
S
I
G
L
S
V
P
P
G
F
T
V
S
T
E
A
C
Q
Q
Y
Q
-
D
A
G
C
-
A
-
L
P
A
G
L
W
A
E
I
V
D
G
L
Q
W
V
E
E
Y
M
G
A
T
L
G
D
P
Q
R
P
L
L
L
S
V
R
S
G
A
A
V
S
M
P
G
M
M
D
T
V
L
N
L
G
L
N
D
E
V
A
A
G
L
A
A
K
S
G
--
E
--
R
F
A
Y
D
S
F
R
R
F
L
D
M
F
G
N
V
V
M
D
I
P
R
S
L
F
E
E
K
L
E
H
M
K
E
S
K
G
L
K
N
D
T
D
L
T
A
S
D
L
K
E
L
V
G
Q
Y
K
E
V
Y
L
S
A
-
K
-
G
-
E
P
F
P
S
D
P
K
K
Q
L
E
L
A
V
L
A
V
F
N
S
W
E
S
P
R
A
K
K
Y
R
S
I
N
Q
I
T
G
L
R
G
T
A
V
N
V
Q
C
M
V
F
G
N
M
G
N
T
S
G
T
G
V
L
F
T
R
N
P
N
T
G
E
K
K
L
Y
G
E
F
L
V
N
A
Q
G
E
D
V
V
A
G
I
R
T
P
------------------
E
D
L
D
------------------
A
M
K
N
L
M
P
Q
A
Y
D
E
L
V
E
N
C
N
I
L
E
S
H
Y
K
E
M
Q
D
I
E
F
T
V
Q
E
N
R
L
W
M
L
Q
C
R
T
G
K
R
T
G
K
S
A
V
K
I
A
V
D
M
V
N
E
G
L
V
E
P
R
S
A
I
K
M
V
E
P
G
H
L
D
Q
L
L
H
P
Q
F
--
E
NPS
A
Y
--
K
--
D
Q
---
V
I
A
T
G
L
P
A
S
P
G
A
A
V
G
Q
V
V
F
T
A
E
D
A
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A
W
H
S
Q
G
K
A
A
I
L
V
R
A
E
T
S
P
E
D
V
G
G
M
H
A
A
V
--
G
I
L
T
E
---
R
G
G
M
T
S
H
A
A
V
V
A
R
G
W
G
K
C
C
V
S
G
C
S
G
I
R
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N
D
A
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K
L
V
T
I
G
G
H
V
L
R
E
G
E
W
L
S
L
N
G
S
T
G
E
V
---
I
L
G
K
Q
P
L
S
P
P
A
--
L
S
G
--
D
L
G
T
F
M
A
W
V
D
D
V
R
K
L
K
V
L
A
N
A
D
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P
D
D
A
L
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A
R
N
N
G
A
Q
G
I
G
L
C
R
T
E
H
M
F
F
A
S
-
D
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R
I
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A
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R
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M
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M
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P
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L
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L
R
Q
Q
A
L
D
R
L
L
P
Y
Q
R
S
D
F
E
G
I
F
R
A
M
D
G
L
P
V
T
I
R
L
L
D
P
P
L
H
E
F
L
P
E
G
N
I
E
--
D
I
V
S
E
L
C
A
E
T
G
A
N
Q
E
D
A
L
A
R
I
E
K
L
S
E
V
N
P
M
L
G
F
R
G
C
R
L
G
I
S
Y
P
E
L
T
E
M
Q
A
R
A
I
F
E
A
A
I
A
M
T
N
Q
-
G
V
Q
V
F
P
E
I
M
V
P
L
V
G
T
-------
P
Q
E
L
-------
G
H
--
Q
V
T
L
I
R
Q
V
A
E
K
V
-------
F
A
N
V
G
K
T
I
G
Y
K
V
G
T
M
I
E
I
P
R
A
A
L
V
A
D
E
I
A
E
Q
A
E
F
F
S
F
G
T
N
D
L
T
Q
M
T
F
G
Y
S
R
-
D
D
V
G
K
F
I
P
V
Y
L
A
Q
G
I
L
Q
H
D
P
F
E
V
L
-
D
Q
R
G
V
G
E
L
V
K
F
A
T
E
R
G
R
K
A
----
R
P
N
L
K
V
G
I
C
G
E
H
G
G
E
P
S
S
V
A
F
F
A
K
A
G
L
D
Y
V
S
C
S
P
F
R
V
P
I
A
R
L
A
A
A
Q
V
L
V
---
44
Fugue
94.93
51%
-76
- C4 -
1JDE
2
PPDK_CLOSY
A:
[1-873]
------------------
A
K
W
V
Y
K
F
E
----
E
G
N
A
S
M
R
N
L
L
G
G
A
G
C
N
L
A
E
M
T
I
L
G
M
P
I
P
Q
G
F
T
V
T
T
E
A
C
T
E
Y
Y
N
S
-
G
K
-
Q
-
I
T
Q
E
I
Q
D
Q
I
F
E
A
I
T
W
L
E
E
L
N
G
K
K
F
G
D
T
E
D
P
L
L
V
S
V
R
S
G
A
R
A
S
M
P
G
M
M
D
T
I
L
N
L
G
L
N
D
V
A
V
E
G
F
A
K
K
T
G
N-
P
--
R
F
A
Y
D
S
Y
R
R
F
I
Q
M
Y
S
D
V
V
M
E
V
P
K
S
H
F
E
K
I
I
D
A
M
K
E
E
K
G
V
H
F
D
T
D
L
T
A
D
D
L
K
E
L
A
E
K
F
K
A
V
Y
K
E
A
M
N
-
G
-
E
E
F
P
Q
E
P
K
D
Q
L
M
G
A
V
K
A
V
F
R
S
W
D
N
P
R
A
I
V
Y
R
R
M
N
D
I
P
G
D
W
G
T
A
V
N
V
Q
T
M
V
F
G
N
K
G
E
T
S
G
T
G
V
A
F
T
R
N
P
S
T
G
E
K
G
I
Y
G
E
Y
L
I
N
A
Q
G
E
D
V
V
A
G
V
R
T
P
------------------
Q
P
I
T
------------------
Q
L
E
N
D
M
P
D
C
Y
K
Q
F
M
D
L
A
M
K
L
E
K
H
F
R
D
M
Q
D
M
E
F
T
I
E
E
G
K
L
Y
F
L
Q
T
R
N
G
K
R
T
A
P
A
A
L
Q
I
A
C
D
L
V
D
E
G
M
I
T
E
E
E
A
V
V
R
I
E
A
K
S
L
D
Q
L
L
H
P
T
F
N
P
A
---
A
L
--
K
--
A
G
E
--
V
I
G
S
A
L
P
A
S
P
G
A
A
A
G
K
V
Y
F
T
A
D
E
A
K
A
A
H
E
K
G
E
R
V
I
L
V
R
L
E
T
S
P
E
D
I
E
G
M
H
A
A
E
--
G
I
L
T
V
---
R
G
G
M
T
S
H
A
A
V
V
A
R
G
M
G
T
C
C
V
S
G
C
G
E
I
K
I
N
E
E
A
K
T
F
E
L
G
G
H
T
F
A
E
G
D
Y
I
S
L
D
G
S
T
G
K
I
--------
E
T
Q
E
A
S
--
V
S
G
--
S
F
E
R
I
M
V
W
A
D
K
F
R
T
L
K
V
R
T
N
A
D
T
P
E
D
T
L
N
A
V
K
L
G
A
E
G
I
G
L
C
R
T
E
H
M
F
F
E
A
-
D
-
R
I
M
K
I
R
K
M
I
L
S
D
S
V
E
A
R
E
E
A
L
N
E
L
I
P
F
Q
K
G
D
F
K
A
M
Y
K
A
L
E
G
R
P
M
T
V
R
Y
L
D
P
P
L
H
E
F
V
P
H
T
--
E
--
E
E
Q
A
E
L
A
K
N
M
G
L
T
L
A
E
V
K
A
K
V
D
E
L
H
E
F
N
P
M
M
G
H
R
G
C
R
L
A
V
T
Y
P
E
I
A
K
M
Q
T
R
A
V
M
E
A
A
I
E
V
K
E
E
T
G
I
D
I
V
P
E
I
M
I
P
L
V
G
E
-------
K
K
E
L
-------
K
F
--
V
K
D
V
V
V
E
V
A
E
Q
V
KKEKGS-
D
M
Q
------
Y
H
I
G
T
M
I
E
I
P
R
A
A
L
T
A
D
A
I
A
E
E
A
E
F
F
S
F
G
T
N
D
L
T
Q
M
T
F
G
F
S
R
-
D
D
A
G
K
F
L
D
S
Y
Y
K
A
K
I
Y
E
S
D
P
F
A
R
L
-
D
Q
T
G
V
G
Q
L
V
E
M
A
V
K
K
G
R
Q
T
----
R
P
G
L
K
C
G
I
C
G
E
H
G
G
D
P
S
S
V
E
F
C
H
K
V
G
L
N
Y
V
S
C
S
P
F
R
V
P
I
A
R
L
A
A
A
Q
A
A
L
N
N
K
6
PsiBlast_PDB
94.34
50%
-77
- C4 -
2DIK
2
PPDK_CLOSY
A:
[2-860]
-------------------
K
W
V
Y
K
F
E
----
E
G
N
A
S
M
R
N
L
L
G
G
K
G
C
N
L
A
E
M
T
I
L
G
M
P
I
P
Q
G
F
T
V
T
T
E
A
C
T
E
Y
Y
N
S
-
G
K
-
Q
-
I
T
Q
E
I
Q
D
Q
I
F
E
A
I
T
W
L
E
E
L
N
G
K
K
F
G
D
T
E
D
P
L
L
V
S
V
R
S
A
A
R
A
S
M
P
G
M
M
D
T
I
L
N
L
G
L
N
D
V
A
V
E
G
F
A
K
K
T
G
--
N
P
-
R
F
A
Y
D
S
Y
R
R
F
I
Q
M
Y
S
D
V
V
M
E
V
P
K
S
H
F
E
K
I
I
D
A
M
K
E
E
K
G
V
H
F
D
T
D
L
T
A
D
D
L
K
E
L
A
E
K
F
K
A
V
Y
K
E
A
-
M
-
N
G
E
E
F
P
Q
E
P
K
D
Q
L
M
G
A
V
K
A
V
F
R
S
W
D
N
P
R
A
I
V
Y
R
R
M
N
D
I
P
G
D
W
G
T
A
V
N
V
Q
T
M
V
F
G
N
K
G
E
T
S
G
T
G
V
A
F
T
R
N
P
S
T
G
E
K
G
I
Y
G
E
Y
L
I
N
A
Q
G
E
D
V
V
A
G
V
R
T
P
Q
P
I
T
------------------------------------
Q
L
E
N
D
M
P
D
C
Y
K
Q
F
M
D
L
A
M
K
L
E
K
H
F
R
D
M
Q
D
M
E
F
T
I
E
E
G
K
L
Y
F
L
Q
T
A
N
G
K
R
T
A
P
A
A
L
Q
I
A
C
D
L
V
D
E
G
M
I
T
E
E
E
A
V
V
R
I
E
A
K
S
L
D
Q
L
L
H
P
T
F
--
N
P
A
-
A
L
--
K
--
A
G
E
--
V
I
G
S
A
L
P
A
S
P
G
A
A
A
G
K
V
Y
F
T
A
D
E
A
K
A
A
H
E
K
G
E
R
V
I
L
V
R
L
E
T
S
P
E
D
I
E
G
M
H
A
A
E
--
G
I
L
T
V
---
R
G
G
M
T
S
H
A
A
V
V
A
R
G
M
G
T
C
C
V
S
G
C
G
E
I
K
I
N
E
E
A
K
T
F
E
L
G
G
H
T
F
A
E
G
D
Y
I
S
L
D
G
S
T
G
K
I
-------
I
E
T
Q
E
A
S
--
V
S
G
--
S
F
E
R
I
M
V
W
A
D
K
F
R
T
L
K
V
R
T
N
A
D
T
P
E
D
T
L
N
A
V
K
L
G
A
E
G
I
G
L
C
R
T
E
H
M
F
F
E
A
-
D
-
R
I
M
K
I
R
K
M
I
L
S
D
S
V
E
A
R
E
E
A
L
N
E
L
I
P
F
Q
K
G
D
F
K
A
M
Y
K
A
L
E
G
R
P
M
T
V
R
Y
L
D
P
P
L
H
E
F
V
P
H
T
--
E
--
E
E
Q
A
E
L
A
K
N
M
G
L
T
L
A
E
V
K
A
K
V
D
E
L
H
E
F
N
P
M
M
G
H
R
G
C
R
L
A
V
T
Y
P
E
I
A
K
M
Q
T
R
A
V
M
E
A
A
I
E
V
K
E
E
T
G
I
D
I
V
P
E
I
M
I
P
L
V
G
E
-------
K
K
E
L
K
F
V
K
D
V
V
V
E
--
V
A
E
Q
V
K
K
E
-
K
G
S
-------
D
M
Q
------
Y
H
I
G
T
M
I
E
I
P
R
A
A
L
T
A
D
A
I
A
E
E
A
E
F
F
S
F
G
T
N
D
L
T
Q
M
T
F
G
F
S
R
-
D
D
A
G
K
F
L
D
S
Y
Y
K
A
K
I
Y
E
S
D
P
F
A
R
L
-
D
Q
T
G
V
G
Q
L
V
E
M
A
V
K
K
G
R
Q
T
----
R
P
G
L
K
C
G
I
C
G
E
H
G
G
D
P
S
S
V
E
F
C
H
K
V
G
L
N
Y
V
S
C
S
P
F
R
V
P
I
A
R
L
A
A
A
Q
A
A
L
N
N
K
9
PsiBlast_PDB
94.04
50%
-88
- C4 -
1VBH
3
PPDK1_MAIZE
A:
[3-873]
------------------
K
K
R
V
F
H
F
G
K
G
K
S
E
G
N
K
T
M
K
E
L
L
G
G
K
G
A
N
L
A
E
M
A
S
I
G
L
S
V
P
P
G
F
T
V
S
T
E
A
C
Q
Q
Y
Q
-
D
A
G
C
-
A
-
L
P
A
G
L
W
A
E
I
V
D
G
L
Q
W
V
E
E
Y
M
G
A
T
L
G
D
P
Q
R
P
L
L
L
S
V
R
S
G
A
A
V
S
M
P
G
M
M
D
T
V
L
N
L
G
L
N
D
E
V
A
A
G
L
A
A
K
S
G
--
E
--
R
F
A
Y
D
S
F
R
R
F
L
D
M
F
G
N
V
V
M
D
I
P
R
S
L
F
E
E
K
L
E
H
M
K
E
S
K
G
L
K
N
D
T
D
L
T
A
S
D
L
K
E
L
V
G
Q
Y
K
E
V
Y
L
S
A
-
K
-
G
-
E
P
F
P
S
D
P
K
K
Q
L
E
L
A
V
L
A
V
F
N
S
W
E
S
P
R
A
K
K
Y
R
S
I
N
Q
I
T
G
L
R
G
T
A
V
N
V
Q
C
M
V
F
G
N
M
G
N
T
S
G
T
G
V
L
F
T
R
N
P
N
T
G
E
K
K
L
Y
G
E
F
L
V
N
A
---------
R
T
P
------------------
E
D
L
D
------------------
A
M
K
N
L
M
P
Q
A
Y
D
E
L
V
E
N
C
N
I
L
E
S
H
Y
K
E
M
Q
D
I
E
F
T
V
Q
E
N
R
L
W
M
L
Q
C
R
T
G
K
R
T
G
K
S
A
V
K
I
A
V
D
M
V
N
E
G
L
V
E
P
R
S
A
I
K
M
V
E
P
G
H
L
D
Q
L
L
H
P
Q
F
--
E
NPS
A
Y
--
K
--
D
Q
---
V
I
A
T
G
L
P
A
S
P
G
A
A
V
G
Q
V
V
F
T
A
E
D
A
E
A
W
H
S
Q
G
K
A
A
I
L
V
R
A
E
T
S
P
E
D
V
G
G
M
H
A
A
V
--
G
I
L
T
E
------
M
T
S
H
A
A
V
V
A
R
G
W
G
K
C
C
V
S
G
C
S
G
I
R
V
N
D
A
E
K
L
V
T
I
G
G
H
V
L
R
E
G
E
W
L
S
L
N
G
S
T
G
E
V
---
I
L
G
K
Q
P
L
S
P
P
A
--
L
S
G
--
D
L
G
T
F
M
A
W
V
D
D
V
R
K
L
K
V
L
A
N
A
D
T
P
D
D
A
L
T
A
R
N
N
G
A
Q
G
I
G
L
C
R
T
E
H
M
F
F
A
S
-
D
E
R
I
K
A
V
R
Q
M
I
M
A
P
T
L
E
L
R
Q
Q
A
L
D
R
L
L
P
Y
Q
R
S
D
F
E
G
I
F
R
A
M
D
G
L
P
V
T
I
R
L
L
D
P
P
L
H
E
F
L
P
E
G
N
I
E
--
D
I
V
S
E
L
C
A
E
T
G
A
N
Q
E
D
A
L
A
R
I
E
K
L
S
E
V
N
P
M
L
G
F
R
G
C
R
L
G
I
S
Y
P
E
L
T
E
M
Q
A
R
A
I
F
E
A
A
I
A
M
T
N
Q
-
G
V
Q
V
F
P
E
I
M
V
P
L
V
G
T
-------
P
Q
E
L
-------
G
H
--
Q
V
T
L
I
R
Q
V
A
E
K
V
-------
F
A
N
V
G
K
T
I
G
Y
K
V
G
T
M
I
E
I
P
R
A
A
L
V
A
D
E
I
A
E
Q
A
E
F
F
S
F
G
T
N
D
L
T
Q
M
T
F
G
Y
S
R
-
D
D
V
G
K
F
I
P
V
Y
L
A
Q
G
I
L
Q
H
D
P
F
E
V
L
-
D
Q
R
G
V
G
E
L
V
K
F
A
T
E
R
G
R
K
A
----
R
P
N
L
K
V
G
I
C
G
E
H
G
G
E
P
S
S
V
A
F
F
A
K
A
G
L
D
Y
V
S
C
S
P
F
R
V
P
I
A
R
L
A
A
A
Q
V
L
V
---
23
HHSearch
91.04
48%
-73
- C4 -
1KBL
6
PPDK_CLOSY
A:
[1-871]
------------------
A
K
W
V
Y
K
F
E
E
G
----
N
A
S
M
R
N
L
L
G
G
K
G
C
N
L
A
E
M
T
I
L
G
M
P
I
P
Q
G
F
T
V
T
T
E
A
C
T
E
Y
Y
-
N
-
S
G
K
Q
-
I
T
Q
E
I
Q
D
Q
I
F
E
A
I
T
W
L
E
E
L
N
G
K
K
F
G
D
T
E
D
P
L
L
V
S
V
R
S
G
A
R
A
S
M
P
G
M
M
D
T
I
L
N
L
G
L
N
D
V
A
V
E
G
F
A
K
K
T
G
N-
P
--
R
F
A
Y
D
S
Y
R
R
F
I
Q
M
Y
S
D
V
V
M
E
V
P
K
S
H
F
E
K
I
I
D
A
M
K
E
E
K
G
V
H
F
D
T
D
L
T
A
D
D
L
K
E
L
A
E
K
F
K
A
V
Y
K
E
A
-
M
N
G
-
E
E
F
P
Q
E
P
K
D
Q
L
M
G
A
V
K
A
V
F
R
S
W
D
N
P
R
A
I
V
Y
R
R
M
N
D
I
P
G
D
W
G
T
A
V
N
V
Q
T
M
V
F
G
N
K
G
E
T
S
G
T
G
V
A
F
T
R
N
P
S
T
G
E
K
G
I
Y
G
E
Y
L
I
N
A
Q
G
E
D
V
V
A
G
V
R
T
P
Q
P
I
T
-------------
Q
L
E
-----------------------
N
D
M
P
D
C
Y
K
Q
F
M
D
L
A
M
K
L
E
K
H
F
R
D
M
Q
D
M
E
F
T
I
E
E
G
K
L
Y
F
L
Q
T
R
N
G
K
R
T
A
P
A
A
L
Q
I
A
C
D
L
V
D
E
G
M
I
T
E
E
E
A
V
V
R
I
E
A
K
S
L
D
Q
L
L
H
P
T
F
--
N
---
P
A
A
L
K
--
A
G
E
--
V
I
G
S
A
L
P
A
S
P
G
A
A
A
G
K
V
Y
F
T
A
D
E
A
K
A
A
H
E
K
G
E
R
V
I
L
V
R
L
E
T
S
P
E
D
I
E
G
M
H
A
A
E
--
G
I
L
T
V
RGG
M
T
S
H
A
A
V
V
A
R
G
M
G
T
C
C
V
S
G
C
G
E
I
K
I
N
E
E
A
K
T
F
E
L
G
G
H
T
F
A
E
G
D
Y
I
S
L
D
G
S
T
G
K
I
Y
K
G
---
D
I
E
T
Q
E
A
S
V
S
-----
G
--
S
F
E
R
I
M
V
W
A
D
K
F
R
T
L
K
V
R
T
N
A
D
T
P
E
D
T
L
N
A
V
K
L
G
A
E
G
I
G
L
C
R
T
E
H
M
F
F
E
A
-
D
-
R
I
M
K
I
R
K
M
I
L
S
D
S
V
E
A
R
E
E
A
L
N
E
L
I
P
F
Q
K
G
D
F
K
A
M
Y
K
A
L
E
G
R
P
M
T
V
R
Y
L
D
P
P
L
H
E
F
V
P
H
T
--
E
--
E
E
Q
A
E
L
A
K
N
M
G
L
T
L
A
E
V
K
A
K
V
D
E
L
H
E
F
N
P
M
M
G
H
R
G
C
R
L
A
V
T
Y
P
E
I
A
K
M
Q
T
R
A
V
M
E
A
A
I
E
V
K
E
E
T
G
I
D
I
V
P
E
I
M
I
P
L
V
G
E
-------
K
K
E
L
-------
K
F
--
V
K
D
V
V
V
E
V
A
E
Q
V
K
K
E
K
GS-
D
M
Q
------
Y
H
I
G
T
M
I
E
I
P
R
A
A
L
T
A
D
A
I
A
E
E
A
E
F
F
S
F
G
T
N
D
L
T
Q
M
T
F
G
F
S
R
-
D
D
A
G
K
F
L
D
S
Y
Y
K
A
K
I
Y
E
S
D
P
F
A
R
L
D
Q
T
-
G
V
G
Q
L
V
E
M
A
V
K
K
G
R
Q
T
----
R
P
G
L
K
C
G
I
C
G
E
H
G
G
D
P
S
S
V
E
F
C
H
K
V
G
L
N
Y
V
S
C
S
P
F
R
V
P
I
A
R
L
A
A
A
Q
A
A
L
N
N
-
24
HHSearch
89.43
48%
-78
- C4 -
1VBG
4
PPDK1_MAIZE
A:
[3-875]
------------------
K
K
R
V
F
H
F
G
K
G
K
S
E
G
N
K
T
M
K
E
L
L
G
G
K
G
A
N
L
A
E
M
A
S
I
G
L
S
V
P
P
G
F
T
V
S
T
E
A
C
Q
Q
Y
Q
-
D
-
A
G
C
A
-
L
P
A
G
L
W
A
E
I
V
D
G
L
Q
W
V
E
E
Y
M
G
A
T
L
G
D
P
Q
R
P
L
L
L
S
V
R
S
G
A
A
V
S
M
P
G
M
M
D
T
V
L
N
L
G
L
N
D
E
V
A
A
G
L
A
A
K
S
G
--
E
--
R
F
A
Y
D
S
F
R
R
F
L
D
M
F
G
N
V
V
M
D
I
P
R
S
L
F
E
E
K
L
E
H
M
K
E
S
K
G
L
K
N
D
T
D
L
T
A
S
D
L
K
E
L
V
G
Q
Y
K
E
V
Y
L
S
A
-
K
-
G
-
E
P
F
P
S
D
P
K
K
Q
L
E
L
A
V
L
A
V
F
N
S
W
E
S
P
R
A
K
K
Y
R
S
I
N
Q
I
T
G
L
R
G
T
A
V
N
V
Q
C
M
V
F
G
N
M
G
N
T
S
G
T
G
V
L
F
T
R
N
P
N
T
G
E
K
K
L
Y
G
E
F
L
V
N
A
Q
G
E
D
V
V
A
G
I
R
T
P
E
D
L
D
-------------
A
M
-----------------------
K
N
L
M
P
Q
A
Y
D
E
L
V
E
N
C
N
I
L
E
S
H
Y
K
E
M
Q
D
I
E
F
T
V
Q
E
N
R
L
W
M
L
Q
C
R
T
G
K
R
T
G
K
S
A
V
K
I
A
V
D
M
V
N
E
G
L
V
E
P
R
S
A
I
K
M
V
E
P
G
H
L
D
Q
L
L
H
P
Q
F
--
E
---
N
P
--
S
AY
K
D
Q
--
V
I
A
T
G
L
P
A
S
P
G
A
A
V
G
Q
V
V
F
T
A
E
D
A
E
A
W
H
S
Q
G
K
A
A
I
L
V
R
A
E
T
S
P
E
D
V
G
G
M
H
A
A
V
--
G
I
L
T
E
RGG
M
T
S
H
A
A
V
V
A
R
G
W
G
K
C
C
V
S
G
C
S
G
I
R
V
N
D
A
E
K
L
V
T
I
G
G
H
V
L
R
E
G
E
W
L
S
L
N
G
S
T
G
E
V
I
L
G
---
K
Q
P
L
S
P
P
A
L
S
-----
G
--
D
L
G
T
F
M
A
W
V
D
D
V
R
K
L
K
V
L
A
N
A
D
T
P
D
D
A
L
T
A
R
N
N
G
A
Q
G
I
G
L
C
R
T
E
H
M
F
F
A
S
D
E
-
R
I
K
A
V
R
Q
M
I
M
A
P
T
L
E
L
R
Q
Q
A
L
D
R
L
L
P
Y
Q
R
S
D
F
E
G
I
F
R
A
M
D
G
L
P
V
T
I
R
L
L
D
P
P
L
H
E
F
L
P
E
G
--
N
I
E
D
I
V
S
E
L
C
A
E
T
G
A
N
Q
E
D
A
L
A
R
I
E
K
L
S
E
V
N
P
M
L
G
F
R
G
C
R
L
G
I
S
Y
P
E
L
T
E
M
Q
A
R
A
I
F
E
A
A
I
A
M
T
-
N
Q
G
V
Q
V
F
P
E
I
M
V
P
L
V
G
T
-------
P
Q
E
L
-------
G
H
--
Q
V
T
L
I
R
Q
V
A
E
K
V
F
A
N
V
G
K
-
T
I
G
------
Y
K
V
G
T
M
I
E
I
P
R
A
A
L
V
A
D
E
I
A
E
Q
A
E
F
F
S
F
G
T
N
D
L
T
Q
M
T
F
G
Y
S
R
-
D
D
V
G
K
F
I
P
V
Y
L
A
Q
G
I
L
Q
H
D
P
F
E
V
L
-
D
Q
R
G
V
G
E
L
V
K
F
A
T
E
R
G
R
K
A
----
R
P
N
L
K
V
G
I
C
G
E
H
G
G
E
P
S
S
V
A
F
F
A
K
A
G
L
D
Y
V
S
C
S
P
F
R
V
P
I
A
R
L
A
A
A
Q
V
L
V
---
22
HHSearch
89.43
48%
-74
- C4 -
2X0S
-
?
A:
[2-896]
-----------------
A
K
K
W
V
Y
Y
F
G
G
G
N
A
D
G
N
K
N
M
K
E
L
L
G
G
K
G
A
N
L
A
E
M
V
N
L
G
I
P
V
P
P
G
F
T
I
T
T
E
A
C
K
T
Y
Q
-
E
-
T
E
-
T
-
I
P
Q
E
V
A
D
Q
V
R
E
N
V
S
R
V
E
K
E
M
G
A
K
F
G
D
P
A
N
P
L
L
F
S
V
R
S
G
A
A
A
S
M
----
D
T
V
L
N
L
G
L
N
K
V
T
V
D
A
W
V
R
R
A
P
RL
E
--
R
F
V
Y
D
S
Y
R
R
F
I
T
M
Y
A
D
I
V
M
Q
V
G
R
E
D
F
E
E
A
L
S
R
M
K
E
R
R
G
T
K
F
D
T
D
L
T
A
S
D
L
K
E
L
C
D
G
Y
L
E
L
F
E
L
K
-
T
-
G
-
C
S
F
P
Q
D
P
V
M
Q
L
F
A
A
I
K
A
V
F
R
S
W
G
N
P
R
A
T
I
Y
R
R
M
N
N
I
T
G
L
L
G
T
A
V
N
V
Q
A
M
V
F
G
N
I
N
D
R
S
A
T
G
V
A
F
S
R
S
P
S
T
G
E
N
F
F
F
G
E
Y
L
V
N
A
Q
G
E
D
V
V
A
G
I
R
T
P
Q
Q
I
N
-------------
H
S
L
S
L
R
W
A
K
A
H
GVG
E
E
E
R
R
K
RYP
S
M
E
E
A
M
P
E
N
Y
R
L
L
C
D
V
R
K
R
L
E
N
H
Y
R
D
M
Q
D
L
E
F
T
V
Q
D
G
R
L
W
L
L
Q
C
R
N
G
K
R
T
I
H
A
A
V
R
I
A
I
D
M
V
N
E
G
L
I
S
R
E
E
A
V
L
R
I
D
P
Y
Q
V
D
H
L
M
H
P
N
L
--
E
---
P
G
--
A
EK
A
N
K
--
P
I
G
R
G
L
A
A
S
P
G
A
A
V
G
Q
V
V
F
D
A
E
S
A
K
E
W
S
G
R
G
K
K
V
I
M
V
R
L
E
T
S
P
E
D
L
A
G
M
D
A
A
C
--
G
I
L
T
A
RGG
M
T
S
H
A
A
V
V
A
R
G
M
G
K
C
C
V
S
G
C
G
D
M
V
I
--
R
G
K
S
F
K
L
N
G
S
V
F
R
E
G
D
Y
I
T
I
D
G
S
K
G
L
I
Y
A
G
---
K
L
K
L
R
S
P
D
L
-----
K
G
--
S
F
Q
T
I
L
Q
W
C
Q
E
M
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49
Fugue
63.72
49%
-84
- C4 -
1DIK
2
?
?:
[510-874]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
E
T
Q
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A
S
--
V
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A
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N
N
K
47
Fugue
59.41
52%
-83
- C4 -
1KBL
1
PPDK_CLOSY
A:
[1-375]
------------------
A
K
W
V
Y
K
-
F
E
---
E
G
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L
L
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Q------------------------------------
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46
Fugue
57.72
52%
-82
- C4 -
1DIK
1
?
?:
[2-376]
------------------
A
K
W
V
Y
K
F
E
----
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A
12
PsiBlast_PDB
50.85
27%
-70
- C4 -
2XDF
-
PT1_ECOLI
A:
[155-531]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
V
I
L
V
A
A
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L
N
L
K
K
VL
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---
A
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G
A
E
R
N
G
A
E
G
V
G
L
Y
R
T
E
F
L
F
M
D
R
-
D
-
A
L
--------------------
P
T
E
E
E
Q
F
A
A
Y
K
A
V
A
E
A
C
G
S
Q
A
V
I
V
R
T
M
D
I
G
G
D
K
E
L
P
---------------
Y
M
N
F
P
-----------
K
E
E
N
P
F
L
G
W
R
A
I
R
I
A
M
D
R
R
E
I
L
R
D
Q
L
R
A
I
L
R
A
--------
S
A
F
G
K
L
R
I
M
F
P
M
I
I
S
V
E
E
V
R
A
L
R
K
E
I
-------
E
I
--
Y
K
Q
E
L
R
D
E
G
K
A
F
-------
D
E
S
------
I
E
I
G
V
M
V
E
T
P
A
A
A
T
I
A
R
H
L
A
K
E
V
D
F
F
S
I
G
T
N
D
L
T
Q
Y
T
L
A
V
D
R
G
N
D
M
I
S
H
L
--------
Y
Q
P
M
S
P
S
V
L
-
N
L
--
I
K
Q
V
I
D
A
S
H
A
E
G
K
W
T
----------
G
M
C
G
E
L
A
G
D
E
R
A
T
L
L
L
L
G
M
G
L
D
E
F
S
M
S
A
I
S
I
P
R
I
K
K
I
I
R
N
T
N
F
E
D
A
16
PsiBlast_PDB
49.25
27%
-70
- C4 -
2L5H
-
PT1_ECOLI
A:
[155-531]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
V
I
L
V
A
A
D
L
T
P
S
E
T
A
Q
L
N
L
K
K
VL
G
F
I
T
D
---
A
G
G
R
T
S
Q
T
S
I
M
A
R
S
L
E
L
P
A
I
V
G
T
G
S
V
T
S
Q
V
K
N
D
D
Y
L
I
L
D
A
V
N
N
Q
---
V
Y
V
N
P
-
T
N
E
V
I
D
K
M
R
A
V
Q
E
Q
V
A
S
E
--
K
A
E
L
A
K
L
K
D
L
P
A
I
T
L
D
G
H
Q
V
E
V
C
A
N
I
G
T
V
R
D
V
E
G
A
E
R
N
G
A
E
G
V
G
L
Y
R
T
E
F
L
F
M
D
R
-
D
-
A
L
--------------------
P
T
E
E
E
Q
F
A
A
Y
K
A
V
A
E
A
C
G
S
Q
A
V
I
V
R
T
M
D
I
G
G
D
K
E
L
P
---------------
Y
M
N
F
P
-----------
K
E
E
N
P
F
L
G
W
R
A
I
R
I
A
M
D
R
R
E
I
L
R
D
Q
L
R
A
I
L
R
A
--------
S
A
F
G
K
L
R
I
M
F
P
M
I
I
S
V
E
E
V
R
A
L
R
K
E
I
-------
E
I
--
Y
K
Q
E
L
R
D
E
G
K
A
F
-------
D
E
S
------
I
E
I
G
V
M
V
E
T
P
A
A
A
T
I
A
R
H
L
A
K
E
V
D
F
F
S
I
G
T
N
D
L
T
Q
Y
T
L
A
V
D
R
G
N
D
M
I
S
H
L
--------
Y
Q
P
M
S
P
S
V
L
-
N
L
--
I
K
Q
V
I
D
A
S
H
A
E
G
K
W
T
----------
G
M
C
G
E
L
A
G
D
E
R
A
T
L
L
L
L
G
M
G
L
D
E
F
S
M
S
A
I
S
I
P
R
I
K
K
I
I
R
N
T
N
F
E
D
A
11
PsiBlast_PDB
49.08
27%
-67
- C4 -
2KX9
-
PT1_ECOLI
A:
[155-531]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
V
I
L
V
A
A
D
L
T
P
S
E
T
A
Q
L
N
L
K
K
VL
G
F
I
T
D
---
A
G
G
R
T
S
H
T
S
I
M
A
R
S
L
E
L
P
A
I
V
G
T
G
S
V
T
S
Q
V
K
N
D
D
Y
L
I
L
D
A
V
N
N
Q
---
V
Y
V
N
P
-
T
N
E
V
I
D
K
M
R
A
V
Q
E
Q
V
A
S
E
--
K
A
E
L
A
K
L
K
D
L
P
A
I
T
L
D
G
H
Q
V
E
V
C
A
N
I
G
T
V
R
D
V
E
G
A
E
R
N
G
A
E
G
V
G
L
Y
R
T
E
F
L
F
M
D
R
-
D
-
A
L
--------------------
P
T
E
E
E
Q
F
A
A
Y
K
A
V
A
E
A
C
G
S
Q
A
V
I
V
R
T
M
D
I
G
G
D
K
E
L
P
---------------
Y
M
N
F
P
-----------
K
E
E
N
P
F
L
G
W
R
A
I
R
I
A
M
D
R
R
E
I
L
R
D
Q
L
R
A
I
L
R
A
--------
S
A
F
G
K
L
R
I
M
F
P
M
I
I
S
V
E
E
V
R
A
L
R
K
E
I
-------
E
I
--
Y
K
Q
E
L
R
D
E
G
K
A
F
-------
D
E
S
------
I
E
I
G
V
M
V
E
T
P
A
A
A
T
I
A
R
H
L
A
K
E
V
D
F
F
S
I
G
T
N
D
L
T
Q
Y
T
L
A
V
D
R
G
N
D
M
I
S
H
L
--------
Y
Q
P
M
S
P
S
V
L
-
N
L
--
I
K
Q
V
I
D
A
S
H
A
E
G
K
W
T
----------
G
M
C
G
E
L
A
G
D
E
R
A
T
L
L
L
L
G
M
G
L
D
E
F
S
M
S
A
I
S
I
P
R
I
K
K
I
I
R
N
T
N
F
E
D
A
28
HHSearch
47.56
36%
-54
- C4 -
2XZ9
2
?
A:
[14-294]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
P
D
G
K
K
-
V
M
L
A
A
N
I
G
T
P
K
D
V
A
S
A
L
A
N
G
A
E
G
V
G
L
F
R
T
E
F
L
Y
M
D
R
-
N
-
S
L
---------
P
S
E
E
-----------
E
Q
F
E
A
Y
K
E
V
V
E
K
M
G
G
R
P
V
T
I
R
T
L
D
I
G
G
D
K
E
L
P
Y
L
--------------------------
D
M
P
K
E
M
N
P
F
L
G
Y
R
A
I
R
L
C
L
D
R
P
D
I
F
K
T
Q
L
R
A
I
L
R
A
S
A
-----
Y
G
---
N
V
Q
I
M
Y
P
M
I
S
S
-------
V
E
E
V
-------
R
K
--
A
N
S
I
L
E
E
V
K
A
E
L
D
R
E
GVKY
D
K
E
------
I
K
V
G
I
M
V
E
I
P
S
A
A
V
T
A
D
I
L
A
K
E
V
D
F
F
S
I
G
T
N
D
L
T
Q
Y
T
L
A
V
D
R
-
M
N
E
--
H
V
K
E
Y
Y
-------
Q
P
---
F
-
H
P
-
A
I
L
R
L
V
K
M
V
I
D
A
A
H
K
E
------
G
K
F
A
A
M
C
G
E
M
A
G
D
P
L
A
A
V
I
L
L
G
L
G
L
D
E
F
S
M
S
A
T
S
I
P
E
I
K
N
I
I
R
N
V
E
Y
E
K
A
13
PsiBlast_PDB
47.01
30%
-64
- C4 -
2XZ7
2
?
A:
[6-283]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
--
Q
L
K
D
L
P
A
E
T
P
D
G
K
K
V
M
L
A
A
N
I
G
T
P
K
D
V
A
S
A
L
A
N
G
A
E
G
V
G
L
F
R
T
E
F
L
Y
M
D
R
-
N
-
S
L
P
S
--------------------
E
E
E
Q
F
E
A
Y
K
E
V
V
E
K
M
G
G
R
P
V
T
I
R
T
L
D
I
G
G
D
K
E
L
P
--------------------------
Y
L
D
M
P
K
E
M
N
P
F
L
G
Y
R
A
I
R
L
C
L
D
R
P
D
I
F
K
T
Q
L
R
A
I
L
R
A
--------
S
A
Y
G
N
V
Q
I
M
Y
P
M
I
S
S
-------
V
E
E
V
R
K
A
N
S
--
I
L
E
E
V
K
A
E
L
D
R
E
G
V
K
Y
-------
D
K
E
------
I
K
V
G
I
M
V
E
I
P
S
A
A
V
T
A
D
I
L
A
K
E
V
D
F
F
S
I
G
T
N
D
L
T
Q
Y
T
L
A
V
D
R
-------
M
N
E
H
V
K
E
Y
Y
---
Q
P
F
H
-----
P
A
I
L
R
L
V
K
M
V
I
D
A
A
H
K
E
----
G
K
--
F
A
A
M
C
G
E
M
A
G
D
P
L
A
A
V
I
L
L
G
L
G
L
D
E
F
S
M
S
A
T
S
I
P
E
I
K
N
I
I
R
N
V
E
Y
E
K
A
14
PsiBlast_PDB
46.29
30%
-61
- C4 -
2XZ9
2
?
A:
[7-282]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
K
D
L
P
A
E
T
P
D
G
K
K
V
M
L
A
A
N
I
G
T
P
K
D
V
A
S
A
L
A
N
G
A
E
G
V
G
L
F
R
T
E
F
L
Y
M
D
R
-
N
-
S
L
P
S
--------------------
E
E
E
Q
F
E
A
Y
K
E
V
V
E
K
M
G
G
R
P
V
T
I
R
T
L
D
I
G
G
D
K
E
L
P
--------------------------
Y
L
D
M
P
K
E
M
N
P
F
L
G
Y
R
A
I
R
L
C
L
D
R
P
D
I
F
K
T
Q
L
R
A
I
L
R
A
--------
S
A
Y
G
N
V
Q
I
M
Y
P
M
I
S
S
-------
V
E
E
V
R
K
A
N
S
--
I
L
E
E
V
K
A
E
L
D
R
E
G
V
K
Y
-------
D
K
E
------
I
K
V
G
I
M
V
E
I
P
S
A
A
V
T
A
D
I
L
A
K
E
V
D
F
F
S
I
G
T
N
D
L
T
Q
Y
T
L
A
V
D
R
-------
M
N
E
H
V
K
E
Y
Y
---
Q
P
F
H
-----
P
A
I
L
R
L
V
K
M
V
I
D
A
A
H
K
E
----
G
K
--
F
A
A
M
C
G
E
M
A
G
D
P
L
A
A
V
I
L
L
G
L
G
L
D
E
F
S
M
S
A
T
S
I
P
E
I
K
N
I
I
R
N
V
E
Y
E
K
A