@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : Wbm0216: (2015-11-29 )
MLFLPLYTSQVLDRVISSESVSTLTMLTIITLSAFACSAMLETCRYLAMAKIGDWIDKAVTPDLIVRSIRLTSVQSSASSGEAIRDLGVIKNFITGNSIFSLFDTPWSLIYLVVIFMIHTSTGFIATIGIIILVSMAVWNELATKRILQETNEETIRNINAIDVATRNAEVVEAMGMSEFIVSDWCKRNDQNRAMQIKAQNRSNVITGITKFLRSTLQISVIGTGALLAITAHKTAGSIIAASILMGRVLAPFDAAVHTWKFLNQARMSYERLQRLILTSPKREQTMALPEPAGKLEFDRVFFTPYGSNKSTIKGVSFVIEPGDVVGVIGPSASGKSTIAKLTVGVWKPISGVVRLDGADVYTWNREIFGNYVGYLPQDIELFNTSVKANIARMRPDPNTEEIIKAAKIAGIHELILSLPNGYDTTIGNFGVTLSGGQKQLLGLARAFYGNTKLLVLDEPNANLDSNGEACLINAINVARKQNTTTIIITHKLPLLSLADKVILMSDGVIYTMGPRDEILSKLVASSSNTTEDEHSSVSG
Atome Classification :
(20 SA)
-------------------------------.........10........20-.---........30........40........50........60........70-.-....-.---.-.80....---....90........100.......110.......120.......130--..-......140-.-----........150---.......160.......170--.........180.......190.......200.......210.......220......--------.230.......240.......250.......260.......270.....-----..280...-.------.----.--.290.--------......300..-....-.310--.-......320.......330.......340.......350-.........360.......370.......380.......390.-...-.---.-.400.......410.......420.......430.......440.......450.......460.......470....-...480........490.......500.......510.......520.......530.......540
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
-------------------------------
M
L
FLP
L
Y
T
S
Q
V
L
D
R
V
ISSES--V---
S
T
L
T
M
L
T
I
I
T
L
S
A
F
A
C
S
A
M
L
E
T
C
R
Y
L
A
M
A
K
I
G
D
W
I
D
KAV
T
P
D
L
I
V
R
S
I
R
L
-
T
-
S
VQS-S---A-SS
G
E
A
I
R
---
D
L
G
V
I
K
N
F
ITGN
S
I
F
S
L
FDT
P
W
S
L
I
Y
L
V
V
I
F
M
IHTST
G
F
I
A
T
I
G
I
I
---
I
L
-
V
S
M
A
V
W
N
---
E
-----
L
A
T
K
R
I
L
Q
ET
N
---
E
E
T
I
RNI
N
A
I
D
VATR
N
A
E
----
V
V
E
A
MG
M
S
E
F
I
V
S
D
W
C
KRNDQN
R
A
M
Q
I
K
AQNRS
N
V
I
T
G
I
T
K
F
L
R
ST
L
Q
I
S
V
I
GT
G
A
L
L
--------
A
I
T
AHKTA
G
S
I
I
A
A
S
I
L
M
G
R
VL
A
P
F
D
A
A
V
H
T
W
K
F
L
N
Q
A
R
M
S
Y
E
R
L
Q
R
L
I
-----LTSPKREQ-T------M----A--LPEPA--------GK
L
E
F
D
R
V
F
F
T
-PYGS-NKST--I-K
G
V
S
F
V
IEPG
D
V
V
G
V
IGPSASGK
S
T
I
A
K
L
T
V
G
VWKPI---S
G
V
V
R
LDG
A
D
V
Y
T
W
N
R
E
I
F
G
N
Y
V
GYLPQ
D
I
E
L
FNTSVKA
N
I
A
R-MRP-D---P-
N
T
E
E
I
I
K
A
A
K
I
A
G
I
H
E
L
I
L
SLPNGYDTTIGN
F
G
V
T
LSG
G
Q
K
Q
L
L
G
L
A
R
A
FYGN
T
K
L
L
V
L
DEPNANLDSNG
E
A
C
L
I
N
A
I
-NVAR-KQN
T
T
T
I
I
I
THKL
P
L
L
S
LA
D
K
V
I
L
MSD
G
V
I
Y
TMG
P
R
D
E
I
L
S
K
L
V
ASSSNTTEDEHSSVSG
102
HHSearch
83.03
25%
-90
- C1 -
3ZDQ
6
ABCBA_HUMAN
A:
[36-572]
--------------------------------
M
S
A
P
F
F
L
G
K
I
I
D
V
I
Y
T
N
P
T
--
V
DY
S
D
N
L
T
R
L
C
L
G
L
S
A
V
F
L
C
G
A
A
A
N
A
I
R
V
Y
L
M
Q
T
S
G
Q
R
I
V
N
R
L
R
T
S
L
F
S
S
I
L
R
Q
-
E
-
V
A
F
F
D
K
T
R
T
G
E
L
I
N
R
L
S
S
---
D
T
A
L
L
G
R
S
V
T
E
N
L
S
D
G
L
R
A
G
A
Q
A
S
V
G
I
S
M
M
F
F
V
S
P
N
L
A
T
F
V
L
S
V
V
P
---
P
V
-
S
I
I
A
V
I
Y
---
G
-----
R
Y
L
R
K
L
T
K
V
T
Q
---
D
S
L
A
Q
A
T
Q
L
A
E
E
R
I
G
N
V
R
----
T
V
R
A
F
G
K
E
M
T
E
I
E
K
Y
A
S
K
V
D
H
V
M
Q
L
A
R
K
E
A
F
A
R
A
G
F
F
G
A
T
G
L
S
G
N
L
I
V
L
S
V
L
Y
K
G
G
L
L
--------
M
G
S
A
H
M
T
V
G
E
L
S
S
F
L
M
Y
A
F
W
V
G
I
S
I
G
G
L
S
S
F
Y
S
E
L
M
K
G
L
G
A
G
G
R
L
W
E
L
L
-----
E
R
E
P
K
L
P
F
-
N
------
E
G
V
I
L
N
--
E
K
S
F
Q
--------
G
A
L
E
F
K
N
V
H
F
A
-
Y
P
A
R
P
E
V
P
I
--
F
-
Q
D
F
S
L
S
I
P
S
G
S
V
T
A
L
V
G
P
S
G
S
G
K
S
T
V
L
S
L
L
L
R
L
Y
D
P
A
---
S
G
T
I
S
L
D
G
H
D
I
R
Q
L
N
P
V
W
L
R
S
K
I
G
T
V
S
Q
E
P
I
L
F
S
C
S
I
A
E
N
I
A
Y
-
G
A
D
-
D
PSS
V
-
T
A
E
E
I
Q
R
V
A
E
V
A
N
A
V
A
F
I
R
N
F
P
Q
G
F
N
T
V
V
G
E
K
G
V
L
L
S
G
G
Q
K
Q
R
I
A
I
A
R
A
L
L
K
N
P
K
I
L
L
L
D
E
A
T
S
A
L
D
A
E
N
E
Y
L
V
Q
E
A
L
-
D
R
L
M
-
D
-
G
R
T
V
L
V
I
A
H
R
L
S
T
I
K
N
A
N
M
V
A
V
L
D
Q
G
K
I
T
E
Y
G
K
H
E
E
L
L
S
K
P
-----------------
4
PsiBlast_PDB
80.52
29%
-94
- C1 -
3QF4
1
Y288_THEMA
B:
[140-579]
-----------------------------------------------------------------------------------------------------------------------------
V
I
N
---
D
V
D
N
I
N
N
-
V
L
G
N
S
I
I
Q
F
F
S
G
I
V
T
L
A
G
A
V
I
M
M
F
R
V
N
V
I
L
S
L
V
T
L
S
I
V
P
L
T
V
L
-
I
T
Q
I
V
S
S
---
Q
T
R
K
Y
F
Y
E
N
Q
R
V
L
G
Q
L
N
G
I
I
E
E
D
I
S
G
L
T
V
I
K
L
F
T
R
E
E
K
----
E
M
E
K
----------
F
D
R
V
N
E
S
L
R
K
V
G
T
K
A
Q
I
F
S
G
V
L
P
P
L
M
N
M
V
N
N
L
G
F
A
L
I
S
G
F
G
G
W
L
--------
A
L
K
D
I
I
T
V
G
T
I
A
T
F
I
G
Y
S
R
Q
F
T
R
P
L
N
E
L
S
N
Q
F
N
M
I
Q
M
A
L
A
S
A
E
R
I
F
E
I
L
-----
D
L
E
E
E
K
D
D
-
P
------
D
----
A
VE
L
R
E
V
R
--------
G
E
I
E
F
K
N
V
W
F
S
--
Y
D
K
-
K
K
P
V
--
L
-
K
D
I
T
F
H
I
K
P
G
Q
K
V
A
L
V
G
P
T
G
S
G
K
T
T
I
V
N
L
L
M
R
F
Y
D
V
D
---
R
G
Q
I
L
V
D
G
I
D
I
R
K
I
K
R
S
S
L
R
S
S
I
G
I
V
L
Q
D
T
I
L
F
S
T
T
V
K
E
N
L
K
Y
-
G
N
P
-
G
---
A
-
T
D
E
E
I
K
E
A
A
K
L
T
H
S
D
H
F
I
K
H
L
P
E
G
Y
E
T
V
L
T
D
N
G
E
D
L
S
Q
G
Q
R
Q
L
L
A
I
T
R
A
F
L
A
N
P
K
I
L
I
L
D
E
A
T
S
N
V
D
T
K
T
E
K
S
-
I
Q
A
A
-
M
W
K
L
-
M
E
G
K
T
S
I
I
I
A
H
R
L
N
T
I
K
N
A
D
L
I
I
V
L
R
D
G
E
I
V
E
M
G
K
H
D
E
L
I
Q
K
R
G
F
Y
Y
E
L
F
T
S
Q
Y
G
L
V
V
E
K
5
PsiBlast_PDB
79.34
29%
-96
- C1 -
4Q4A
1
Y288_THEMA
B:
[140-579]
-----------------------------------------------------------------------------------------------------------------------------
V
I
N
---
D
V
D
N
I
N
N
-
V
L
G
N
S
I
I
Q
F
F
S
G
I
V
T
L
A
G
A
V
I
M
M
F
R
V
N
V
I
L
S
L
V
T
L
S
I
V
P
L
T
V
L
-
I
T
Q
I
V
S
S
---
Q
T
R
K
Y
F
Y
E
N
Q
R
V
L
G
Q
L
N
G
I
I
E
E
D
I
S
G
L
T
V
I
K
L
F
T
R
E
E
K
----
E
M
E
K
----------
F
D
R
V
N
E
S
L
R
K
V
G
T
K
A
Q
I
F
S
G
V
L
P
P
L
M
N
M
V
N
N
L
G
F
A
L
I
S
G
F
G
G
W
L
--------
A
L
K
D
I
I
T
V
G
T
I
A
T
F
I
G
Y
S
R
Q
F
T
R
P
L
N
E
L
S
N
Q
F
N
M
I
Q
M
A
L
A
S
A
E
R
I
F
E
I
L
-----
D
L
E
E
E
K
D
D
-
P
------
D
----
A
VE
L
R
E
V
R
--------
G
E
I
E
F
K
N
V
W
F
S
--
Y
D
K
-
K
K
P
V
--
L
-
K
D
I
T
F
H
I
K
P
G
Q
K
V
A
L
V
G
P
T
G
S
G
K
T
T
I
V
N
L
L
M
R
F
Y
D
V
D
---
R
G
Q
I
L
V
D
G
I
D
I
R
K
I
K
R
S
S
L
R
S
S
I
G
I
V
L
Q
D
T
I
L
F
S
T
T
V
K
E
N
L
K
Y
-
G
N
P
-
G
---
A
-
T
D
E
E
I
K
E
A
A
K
L
T
H
S
D
H
F
I
K
H
L
P
E
G
Y
E
T
V
L
T
D
N
G
E
D
L
S
Q
G
Q
R
Q
L
L
A
I
T
R
A
F
L
A
N
P
K
I
L
I
L
D
E
A
T
S
N
V
D
T
K
T
E
K
S
-
I
Q
A
A
-
M
W
K
L
-
M
E
G
K
T
S
I
I
I
A
H
R
L
N
T
I
K
N
A
D
L
I
I
V
L
R
D
G
E
I
V
E
M
G
K
H
D
E
L
I
Q
K
R
G
F
Y
Y
E
L
F
T
S
Q
Y
G
L
----
6
PsiBlast_PDB
79.14
29%
-93
- C1 -
4Q4H
-
Y288_THEMA
B:
[140-579]
-----------------------------------------------------------------------------------------------------------------------------
V
I
N
---
D
V
D
N
I
N
N
-
V
L
G
N
S
I
I
Q
F
F
S
G
I
V
T
L
A
G
A
V
I
M
M
F
R
V
N
V
I
L
S
L
V
T
L
S
I
V
P
L
T
V
L
-
I
T
Q
I
V
S
S
---
Q
T
R
K
Y
F
Y
E
N
Q
R
V
L
G
Q
L
N
G
I
I
E
E
D
I
S
G
L
T
V
I
K
L
F
T
R
E
E
K
----
E
M
E
K
----------
F
D
R
V
N
E
S
L
R
K
V
G
T
K
A
Q
I
F
S
G
V
L
P
P
L
M
N
M
V
N
N
L
G
F
A
L
I
S
G
F
G
G
W
L
--------
A
L
K
D
I
I
T
V
G
T
I
A
T
F
I
G
Y
S
R
Q
F
T
R
P
L
N
E
L
S
N
Q
F
N
M
I
Q
M
A
L
A
S
A
E
R
I
F
E
I
L
-----
D
L
E
E
E
K
D
D
-
P
------
D
----
A
VE
L
R
E
V
R
--------
G
E
I
E
F
K
N
V
W
F
S
--
Y
D
K
-
K
K
P
V
--
L
-
K
D
I
T
F
H
I
K
P
G
Q
K
V
A
L
V
G
P
T
G
S
G
K
T
T
I
V
N
L
L
M
R
F
Y
D
V
D
---
R
G
Q
I
L
V
D
G
I
D
I
R
K
I
K
R
S
S
L
R
S
S
I
G
I
V
L
Q
D
T
I
L
F
S
T
T
V
K
E
N
L
K
Y
-
G
N
P
-
G
---
A
-
T
D
E
E
I
K
E
A
A
K
L
T
H
S
D
H
F
I
K
H
L
P
E
G
Y
E
T
V
L
T
D
N
G
E
D
L
S
Q
G
Q
R
Q
L
L
A
I
T
R
A
F
L
A
N
P
K
I
L
I
L
D
E
A
T
S
N
V
D
T
K
T
E
K
S
-
I
Q
A
A
-
M
W
K
L
-
M
E
G
K
T
S
I
I
I
A
H
R
L
N
T
I
K
N
A
D
L
I
I
V
L
R
D
G
E
I
V
E
M
G
K
H
D
E
L
I
Q
K
R
G
F
Y
Y
E
L
F
T
S
Q
Y
G
-----
8
PsiBlast_PDB
77.51
26%
-92
- C1 -
4RY2
-
?
A:
[191-712]
------------------------------------
F
Y
I
K
F
L
F
D
D
L
I
K
F
E
K
--
L
---
N
D
L
H
I
I
S
A
G
F
A
V
I
F
L
L
Q
I
F
L
N
Y
Y
R
S
I
L
V
T
K
L
G
M
S
I
D
K
S
I
M
M
E
Y
Y
S
H
V
L
K
L
P
M
-
N
F
F
N
-
S
---
R
-
K
V
G
E
I
I
S
R
F
M
D
A
S
K
I
R
Q
A
I
S
G
A
T
L
T
I
M
I
D
T
I
M
A
V
I
G
G
I
L
L
Y
I
Q
N
S
S
L
F
F
I
S
F
I
I
I
L
---
L
Y
G
I
I
V
T
V
F
N
K
P
I
Q
-----
N
A
N
R
Q
I
M
E
D
N
A
---
K
L
T
----
S
A
L
V
E
S
V
K
G
I
E
----
T
I
K
S
F
G
A
E
E
--------
Q
T
E
K
S
T
R
D
K
I
E
T
V
M
K
S
S
F
K
E
G
M
L
Y
I
N
L
S
S
L
T
G
I
V
A
G
L
G
G
I
V
I
L
W
A
G
A
Y
N
V
I
K
G
N
M
S
G
G
Q
L
L
A
F
N
A
L
L
A
Y
F
L
T
P
V
K
N
L
I
D
L
Q
P
L
I
Q
T
A
V
V
A
S
N
R
L
G
E
I
L
-----
E
L
A
T
E
K
E
-----------------
L
------------
G
D
I
E
F
R
N
V
D
F
R
--
Y
G
L
-
R
K
P
V
--
L
-
K
N
I
N
L
T
I
P
K
G
K
T
V
A
I
V
G
E
S
G
S
G
K
T
T
L
A
K
L
L
M
N
F
Y
S
P
E
---
K
G
D
I
L
I
N
G
H
S
I
K
N
I
S
L
E
L
I
R
K
K
I
A
F
V
S
Q
D
V
F
I
F
S
G
T
V
K
E
N
L
C
L
-
G
N
E
-
N
---
V
-
D
M
D
E
I
I
K
A
A
K
M
A
N
A
H
D
F
I
E
K
L
P
L
K
Y
D
T
F
L
N
E
S
G
A
N
L
S
E
G
Q
K
Q
R
L
A
I
A
R
A
L
L
K
K
P
D
I
L
I
L
D
E
A
T
S
N
L
D
S
I
T
E
N
H
I
K
D
A
I
--
Y
G
L
-
E
D
D
V
T
V
I
I
I
A
H
R
L
S
T
I
V
N
C
D
K
I
Y
L
L
K
D
G
E
I
V
E
S
G
S
H
T
E
L
I
A
L
K
G
C
Y
F
K
M
W
K
Q
T
E
N
T
----
9
PsiBlast_PDB
76.56
25%
-84
- C1 -
4S0F
2
?
A:
[191-712]
------------------------------------
F
Y
I
K
F
L
F
D
D
L
I
K
F
E
K
--
L
---
N
D
L
H
I
I
S
A
G
F
A
V
I
F
L
L
Q
I
F
L
N
Y
Y
R
S
I
L
V
T
K
L
G
M
S
I
D
K
S
I
M
M
E
Y
Y
S
H
V
L
K
L
P
M
-
N
F
F
N
-
S
---
R
-
K
V
G
E
I
I
S
R
F
M
D
A
S
K
I
R
Q
A
I
S
G
A
T
L
T
I
M
I
D
T
I
M
A
V
I
G
G
I
L
L
Y
I
Q
N
S
S
L
F
F
I
S
F
I
I
I
L
---
L
Y
G
I
I
V
T
V
F
N
K
P
I
Q
-----
N
A
N
R
Q
I
M
E
D
N
A
---
K
L
T
----
S
A
L
V
E
S
V
K
G
I
E
----
T
I
K
S
F
G
A
E
E
--------
Q
T
E
K
S
T
R
D
K
I
E
T
V
M
K
S
S
F
K
E
G
M
L
Y
I
N
L
S
S
L
T
G
I
V
A
G
L
G
G
I
V
I
L
W
A
G
A
Y
N
V
I
K
G
N
M
S
G
G
Q
L
L
A
F
N
A
L
L
A
Y
F
L
T
P
V
K
N
L
I
D
L
Q
P
L
I
Q
T
A
V
V
A
S
N
R
L
G
E
I
L
-----
E
L
A
T
E
K
E
-----------------
L
R
E
D
S
DDFVISL
K
G
D
I
E
F
R
N
V
D
F
R
--
Y
G
L
-
R
K
P
V
--
L
-
K
N
I
N
L
T
I
P
K
G
K
T
V
A
I
V
G
E
S
G
S
G
K
T
T
L
A
K
L
L
M
N
F
Y
S
P
E
---
K
G
D
I
L
I
N
G
H
S
I
K
N
I
S
L
E
L
I
R
K
K
I
A
F
V
S
Q
D
V
F
I
F
S
G
T
V
K
E
N
L
C
L
-
G
N
E
-
N
---
V
-
D
M
D
E
I
I
K
A
A
K
M
A
N
A
H
D
F
I
E
K
L
P
L
K
Y
D
T
F
L
N
E
S
G
A
N
L
S
E
G
Q
K
Q
R
L
A
I
A
R
A
L
L
K
K
P
D
I
L
I
L
D
Q
A
T
S
N
L
D
S
I
T
E
N
H
I
K
D
A
I
--
Y
G
L
-
E
D
D
V
T
V
I
I
I
A
H
R
L
S
T
I
V
N
C
D
K
I
Y
L
L
K
D
G
E
I
V
E
S
G
S
H
T
E
L
I
A
L
K
G
C
Y
F
K
M
W
K
Q
T
E
------
7
PsiBlast_PDB
73.95
30%
-90
- C1 -
4Q4J
-
?
A:
[192-566]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
K
I
Q
E
S
T
---
D
E
V
N
R
V
V
R
E
N
L
L
G
V
R
-------
V
V
R
A
F
R
R
E
E
Y
E
N
E
N
F
R
K
A
N
E
S
L
R
R
S
I
I
S
A
F
S
L
I
V
F
A
L
P
L
F
I
F
I
V
N
M
G
M
I
A
V
L
W
F
G
G
V
L
--------
V
R
N
N
Q
M
E
I
G
S
I
M
A
Y
T
N
Y
L
M
Q
I
M
F
S
L
M
M
I
G
N
I
L
N
F
I
V
R
A
S
A
S
A
K
R
V
L
E
V
L
-----
N
E
K
P
A
I
E
E
-
A
DN
A
---
L
----
A
--
L
P
N
V
E
--------
G
S
V
S
F
E
N
V
E
F
R
-
Y
F
E
N
-
T
D
P
V
--
L
-
S
G
V
N
F
S
V
K
P
G
S
L
V
A
V
L
G
E
T
G
S
G
K
S
T
L
M
N
L
I
P
R
L
I
D
P
E
---
R
G
R
V
E
V
D
E
L
D
V
R
T
V
K
L
K
D
L
R
G
H
I
S
A
V
P
Q
E
T
V
L
F
S
G
T
I
K
E
N
L
K
W
-
G
R
E
-
D
---
A
-
T
D
D
E
I
V
E
A
A
K
I
A
Q
I
H
D
F
I
I
S
L
P
E
G
Y
D
S
R
V
E
R
G
G
R
N
F
S
G
G
Q
K
Q
R
L
S
I
A
R
A
L
V
K
K
P
K
V
L
I
L
D
D
S
T
C
S
V
D
P
I
T
E
K
R
I
L
D
G
L
-
K
R
Y
T
-
K
-
G
S
T
T
F
I
I
T
Q
K
I
P
T
A
L
L
A
D
K
I
L
V
L
H
E
G
K
V
A
G
F
G
T
H
K
E
L
L
E
H
S
K
P
Y
R
E
I
Y
E
S
Q
F
------
103
HHSearch
71.93
19%
-91
- C1 -
3WMG
3
?
A:
[45-582]
---------------------------------
A
F
A
I
V
F
G
R
M
F
Q
V
F
T
K
S
K
S
Q
I
E
---
G
E
T
W
K
Y
S
V
G
F
V
G
I
G
V
F
E
F
I
V
A
G
S
R
T
A
L
F
G
I
A
S
E
R
L
A
R
D
L
R
V
A
A
F
S
N
L
V
E
Q
-
D
-
V
T
Y
F
D
R
RKA
G
E
L
G
G
K
L
N
N
---
D
V
Q
V
I
Q
Y
S
F
S
K
-
L
G
A
V
L
F
N
L
A
Q
C
V
V
G
I
I
V
A
F
I
F
A
P
A
L
T
G
V
L
I
A
L
S
P
---
L
V
-
V
L
A
V
V
V
Q
---
M
-----
I
E
M
S
G
N
T
K
R
S
S
---
E
A
Y
A
S
A
G
S
V
A
A
E
V
F
S
N
I
R
----
T
T
K
A
F
E
A
E
R
Y
E
T
Q
R
Y
G
S
K
L
D
P
L
Y
R
L
G
R
R
R
Y
I
S
D
G
L
F
F
G
L
S
M
L
V
I
F
C
V
Y
A
L
A
L
W
W
G
G
Q
L
--------
I
A
R
G
S
L
N
L
G
N
L
L
T
A
F
F
S
A
I
L
G
F
M
G
V
G
Q
A
A
Q
V
W
P
D
V
T
R
G
L
G
A
G
G
E
L
F
A
M
I
-----
D
R
V
P
Q
Y
R
R
P
D
PG
A
E
V
V
T
----
Q
--
P
L
V
L
K
--------
Q
G
I
V
F
E
N
V
H
F
R
-
Y
P
T
R
M
N
V
E
V
--
L
-
R
G
I
S
L
T
I
P
N
G
K
T
V
A
I
V
G
G
S
G
A
G
K
S
T
I
I
Q
L
L
M
R
F
Y
D
I
E
PQG
G
G
L
L
L
F
D
G
T
P
A
W
N
Y
D
F
H
A
L
R
S
Q
I
G
L
V
S
Q
E
P
V
L
F
S
G
T
I
R
D
N
I
L
Y
-
G
K
R
-
D
---
A
-
T
D
E
E
V
I
Q
A
L
R
E
A
N
A
Y
S
F
V
M
A
L
P
D
G
L
D
T
E
V
G
E
R
G
L
A
L
S
G
G
Q
K
Q
R
I
A
I
A
R
A
I
L
K
H
P
T
L
L
C
L
D
E
S
T
S
A
L
D
A
E
S
E
A
L
V
Q
E
A
L
-
D
R
M
M
A
S
D
G
V
T
S
V
V
I
A
H
R
L
S
T
V
A
R
A
D
L
I
L
V
M
Q
D
G
V
V
V
E
Q
G
N
H
S
E
L
M
A
L
G
P
S
G
F
Y
Y
Q
L
V
E
K
Q
L
A
S
--
122
Fugue
71.10
21%
-76
- C1 -
3B60
2
MSBA_SALTY
A:
[10-581]
W
Q
T
F
R
R
L
W
P
T
I
A
PFK
A
G
L
I
V
A
G
I
A
L
I
L
N
A
A
S
D
T
F
M
L
S
L
L
K
P
L
L
D
D
G
F
G
K
T
D
--
R
---
S
V
L
L
W
M
P
L
V
V
I
G
L
M
I
L
R
G
I
T
S
Y
I
S
S
Y
C
I
S
W
V
S
G
K
V
V
M
T
M
R
R
R
L
F
G
H
M
M
G
M
-
P
V
A
F
F
D
-
K
---
Q
-
S
T
G
T
L
L
S
---
R
I
T
Y
D
S
E
Q
V
A
S
S
S
S
G
A
L
I
T
V
V
R
E
G
A
S
I
I
G
L
F
I
M
M
F
Y
Y
S
W
Q
L
S
I
I
L
V
---
V
L
-
A
P
I
V
S
I
A
---
I
-----
R
V
V
S
K
R
F
R
S
I
S
---
K
N
M
Q
N
T
M
G
Q
V
T
T
S
A
E
Q
M
L
K
G
H
K
E
V
L
I
F
G
G
Q
E
V
E
T
K
R
F
D
K
V
S
N
K
M
R
L
Q
G
M
K
M
V
S
A
S
S
I
S
D
P
I
I
Q
L
I
A
S
L
A
L
A
F
V
L
Y
A
A
S
F
P
--------
S
V
M
D
S
L
T
A
G
T
I
T
V
V
F
S
S
M
I
A
L
M
R
P
L
K
S
L
T
N
V
N
A
Q
F
Q
R
G
M
A
A
C
Q
T
L
F
A
I
L
-----
D
S
E
Q
E
K
D
E
G
K
------
R
----
V
--
I
D
R
A
T
--------
G
D
L
E
F
R
N
V
T
F
T
-
Y
P
G
R
-
E
V
P
A
--
L
-
R
N
I
N
L
K
I
P
A
G
K
T
V
A
L
V
G
R
S
G
S
G
K
S
T
I
A
S
L
I
T
R
F
Y
D
I
D
---
E
G
H
I
L
M
D
G
H
D
L
R
E
Y
T
L
A
S
L
R
N
Q
V
A
L
V
S
Q
N
V
H
L
F
N
D
T
V
A
N
N
I
A
Y
-
A
R
T
-
E
---
E
Y
S
R
E
Q
I
E
E
A
A
R
M
A
Y
A
M
D
F
I
N
K
M
D
N
G
L
D
T
I
I
G
E
N
G
V
L
L
S
G
G
Q
R
Q
R
I
A
I
A
R
A
L
L
R
D
S
P
I
L
I
L
D
E
A
T
S
A
L
D
T
E
S
E
R
A
I
Q
A
A
L
-
D
E
L
Q
-
K
-
N
R
T
S
L
V
I
A
H
R
L
S
T
I
E
Q
A
D
E
I
V
V
V
E
D
G
I
I
V
E
R
G
T
H
S
E
L
L
A
Q
-----
H
G
V
Y
A
Q
L
H
K
M
Q
F
G
100
HHSearch
69.21
21%
-79
- C1 -
3B60
2
MSBA_SALTY
A:
[44-570]
----------------------------------
M
L
S
L
L
K
P
L
L
D
D
G
F
G
K
T
D
--
R
---
S
V
L
L
W
M
P
L
V
V
I
G
L
M
I
L
R
G
I
T
S
Y
I
S
S
Y
C
I
S
W
V
S
G
K
V
V
M
T
M
R
R
R
L
F
G
H
M
M
G
M
-
P
-
V
A
F
F
D
K
QS
T
G
T
L
L
S
R
I
T
Y
---
D
S
E
Q
V
A
S
S
S
S
G
A
L
I
T
V
V
R
E
G
A
S
I
I
G
L
F
I
M
M
F
Y
Y
S
W
Q
L
S
I
I
L
V
V
L
A
P
---
I
V
-
S
I
A
I
R
V
V
---
S
-----
K
R
F
R
S
I
S
K
N
M
Q
---
N
T
M
G
Q
V
T
T
S
A
E
Q
M
L
K
G
H
K
----
E
V
L
I
F
G
G
Q
E
V
E
T
K
R
F
D
K
V
S
N
K
M
R
L
Q
G
M
K
M
V
S
A
S
S
I
S
D
P
I
I
Q
L
I
A
S
L
A
L
A
F
V
L
Y
A
A
S
F
P
--------
S
V
M
D
S
L
T
A
G
T
I
T
V
V
F
S
S
M
I
A
L
M
R
P
L
K
S
L
T
N
V
N
A
Q
F
Q
R
G
M
A
A
C
Q
T
L
F
A
I
L
-----
D
S
E
Q
E
K
D
E
-
G
K
-----
R
----
V
--
I
D
R
A
T
--------
G
D
L
E
F
R
N
V
T
F
T
-
Y
P
G
R
-
E
V
P
A
--
L
-
R
N
I
N
L
K
I
P
A
G
K
T
V
A
L
V
G
R
S
G
S
G
K
S
T
I
A
S
L
I
T
R
F
Y
D
I
D
---
E
G
H
I
L
M
D
G
H
D
L
R
E
Y
T
L
A
S
L
R
N
Q
V
A
L
V
S
Q
N
V
H
L
F
N
D
T
V
A
N
N
I
A
Y
-
A
R
T
E
E
---
Y
-
S
R
E
Q
I
E
E
A
A
R
M
A
Y
A
M
D
F
I
N
K
M
D
N
G
L
D
T
I
I
G
E
N
G
V
L
L
S
G
G
Q
R
Q
R
I
A
I
A
R
A
L
L
R
D
S
P
I
L
I
L
D
E
A
T
S
A
L
D
T
E
S
E
R
A
I
Q
A
A
L
-
D
E
L
Q
-
K
-
N
R
T
S
L
V
I
A
H
R
L
S
T
I
E
Q
A
D
E
I
V
V
V
E
D
G
I
I
V
E
R
G
T
H
S
E
L
L
A
Q
H
G
V
Y
A
Q
L
H
K
M
Q
F
G
-----
36
PsiBlast_CBE
68.48
37%
-129
- C1 -
2GHI
1
?
D:
[18-241]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
E
F
S
D
V
N
F
S
Y------
H
R
T
--
L
-
K
S
I
N
F
F
I
P
S
G
T
T
C
A
L
V
G
H
T
G
S
G
K
S
T
I
A
K
L
L
Y
R
F
Y
D
A
----
E
G
D
I
K
I
G
G
K
N
V
N
K
Y
N
R
N
S
I
R
S
I
I
G
I
V
P
Q
D
T
I
L
F
N
E
T
I
K
Y
N
I
L
Y
-
G
K
L
-
D
---
A
-
T
D
E
E
V
I
K
A
T
K
S
A
Q
L
Y
D
F
I
E
A
L
P
K
K
W
D
T
I
V
------
L
S
G
G
E
R
Q
R
I
A
I
A
R
C
L
L
K
D
P
K
I
V
I
F
D
------
D
S
K
T
E
Y
L
F
Q
K
A
V
-
E
D
-----
N
R
T
L
I
I
I
A
H
R
L
S
T
I
S
S
A
E
S
I
I
L
L
N
K
G
K
I
V
E
K
G
T
H
K
D
L
L
K
L
N
G
E
Y
A
E
M
W
N
M
Q
-------
37
PsiBlast_CBE
68.31
37%
-112
- C1 -
2GHI
4
?
C:
[18-241]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
E
F
S
D
V
N
F
S
Y
P
K
Q
T
-
N
H
R
T
--
L
-
K
S
I
N
F
F
I
P
S
G
T
T
C
A
L
V
G
H
T
G
S
G
K
S
T
I
A
K
L
L
Y
R
F
Y
D
A
----
E
G
D
I
K
I
G
G
K
N
V
N
K
Y
N
R
N
S
I
R
S
I
I
G
I
V
P
Q
D
T
I
L
F
N
E
T
I
K
Y
N
I
L
Y
-
G
K
L
-
D
---
A
-
T
-
E
E
V
I
K
A
T
K
S
A
Q
L
Y
D
F
I
E
A
L
P
K
K
W
D
T
I
V
G
--
G
M
K
L
--
G
E
R
Q
R
I
A
I
A
R
C
L
L
K
D
P
K
I
V
I
F
D
E
A
T
S
S
L
D
S
K
T
E
Y
L
F
Q
K
A
V
-
E
D
L
R
-
K
-
N
R
T
L
I
I
I
A
H
R
L
S
T
I
S
S
A
E
S
I
I
L
L
N
K
G
K
I
V
E
K
G
T
H
K
D
L
L
K
L
N
G
E
Y
A
E
M
W
N
M
Q
-------
38
PsiBlast_CBE
67.68
37%
-111
- C1 -
2GHI
3
?
B:
[18-241]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
E
F
S
D
V
N
F
S
Y
P
K
Q
T
-
N
H
R
T
--
L
-
K
S
I
N
F
F
I
P
S
G
T
T
C
A
L
V
G
H
T
G
S
G
K
S
T
I
A
K
L
L
Y
R
F
Y
D
A
----
E
G
D
I
K
I
G
G
K
N
V
N
K
Y
N
R
N
S
I
R
S
I
I
G
I
V
P
Q
D
T
I
L
F
N
E
T
I
K
Y
N
I
L
Y
-
G
K
L
-
D
---
A
-
T
D
E
E
V
I
K
A
T
K
S
A
Q
L
Y
D
F
I
E
A
L
P
K
K
W
D
T
I
V
G
N
K
-
M
K
L
S
G
G
E
R
Q
R
I
A
I
A
R
C
L
L
K
D
P
K
I
V
I
F
D
E
A
T
S
--
D
S
K
T
E
Y
L
F
Q
K
A
V
-
E
D
L
R
-
K
-
N
R
T
L
I
I
I
A
H
R
--
T
I
S
S
A
E
S
I
I
L
L
N
K
G
K
I
V
E
K
G
T
H
K
D
L
L
K
L
N
G
E
Y
A
E
M
W
N
M
Q
-------
22
PsiBlast_CBE
67.28
34%
-104
- C1 -
2HYD
3
Y1866_STAAM
B:
[260-565]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
I
V
I
G
V
G
A
Y
L
--------
A
I
S
G
S
I
T
V
G
T
L
A
A
F
V
G
Y
L
E
L
L
F
G
P
L
R
R
L
V
A
S
F
T
T
L
T
Q
S
F
A
S
M
D
R
V
F
Q
L
I
DEDYD
I
K
N
G
V
G
A
Q
-
P
------
I
----
E
--
I
K
Q
----------
G
R
I
D
I
D
H
V
S
F
Q
--
Y
N
D
-
N
E
A
P
--
I
L
K
D
I
N
L
S
I
E
K
G
E
T
V
A
F
V
G
M
S
G
G
G
K
S
T
L
I
N
L
I
P
R
F
Y
D
V
T
---
S
G
Q
I
L
I
D
G
H
N
I
K
D
F
L
T
G
S
L
R
N
Q
I
G
L
V
Q
Q
D
N
I
L
F
S
D
T
V
K
E
N
I
L
L
-
G
R
P
-
T
---
A
-
T
D
E
E
V
V
E
A
A
K
M
A
N
A
H
D
F
I
M
N
L
P
Q
G
Y
D
T
E
V
G
E
R
G
V
K
L
S
G
G
Q
K
Q
R
L
S
I
A
R
I
F
L
N
N
P
P
I
L
I
L
D
E
A
T
S
A
L
D
L
E
S
E
S
I
I
Q
E
A
L
-
D
V
L
S
-
K
-
D
R
T
T
L
I
V
A
H
R
L
S
T
I
T
H
A
D
K
I
V
V
I
E
N
G
H
I
V
E
T
G
T
H
R
E
L
I
A
K
Q
G
A
Y
E
H
L
Y
S
I
Q
N
L
-----
20
PsiBlast_PDB
66.77
37%
-117
- C1 -
4Q9J
-
MDR1A_MOUSE
A:
[386-614]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
N
L
E
F
K
N
I
H
F
S
--
Y
P
S
-
R
K
E
V
QI
L
-
K
G
L
N
L
K
V
K
S
G
Q
T
V
A
L
V
G
N
S
G
C
G
K
S
T
T
V
Q
L
M
Q
R
L
Y
D
P
L
---
D
G
M
V
S
I
D
G
Q
D
I
R
T
I
N
V
R
Y
L
R
E
I
I
G
V
V
S
Q
E
P
V
L
F
A
T
T
I
A
E
N
I
R
Y
-
G
R
E
-
D
---
V
-
T
M
D
E
I
E
K
A
V
K
E
A
N
A
Y
D
F
I
M
K
L
P
H
Q
F
D
T
L
V
G
E
R
G
A
Q
L
S
G
G
Q
K
Q
R
I
A
I
A
R
A
L
V
R
N
P
K
I
L
L
L
D
E
A
T
S
A
L
D
T
E
S
E
A
V
V
Q
A
A
L
-
D
K
A
R
--
E
G
R
T
T
I
V
I
A
H
R
L
S
T
V
R
N
A
D
V
I
A
G
F
D
G
G
V
I
V
E
Q
G
N
H
D
E
L
M
R
E
K
G
I
Y
F
K
L
V
M
T
Q
T
P
P
A
S
F
W
1
PsiBlast_PDB
66.60
34%
-103
- C1 -
2HYD
3
Y1866_STAAM
A:
[260-565]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
I
V
I
G
V
G
A
Y
L
--------
A
I
S
G
S
I
T
V
G
T
L
A
A
F
V
G
Y
L
E
L
L
F
G
P
L
R
R
L
V
A
S
F
T
T
L
T
Q
S
F
A
S
M
D
R
V
F
Q
L
I
D
EDYD
I
K
N
G
V
G
A
Q
-
P
------
I
----
E
--
I
K
Q
----------
G
R
I
D
I
D
H
V
S
F
Q
--
Y
N
D
-
N
E
A
P
--
I
L
K
D
I
N
L
S
I
E
K
G
E
T
V
A
F
V
G
M
S
G
G
G
K
S
T
L
I
N
L
I
P
R
F
Y
D
V
T
---
S
G
Q
I
L
I
D
G
H
N
I
K
D
F
L
T
G
S
L
R
N
Q
I
G
L
V
Q
Q
D
N
I
L
F
S
D
T
V
K
E
N
I
L
L
-
G
R
P
-
T
---
A
-
T
D
E
E
V
V
E
A
A
K
M
A
N
A
H
D
F
I
M
N
L
P
Q
G
Y
D
T
E
V
G
E
R
G
V
K
L
S
G
G
Q
K
Q
R
L
S
I
A
R
I
F
L
N
N
P
P
I
L
I
L
D
E
A
T
S
A
L
D
L
E
S
E
S
I
I
Q
E
A
L
-
D
V
L
S
-
K
-
D
R
T
T
L
I
V
A
H
R
L
S
T
I
T
H
A
D
K
I
V
V
I
E
N
G
H
I
V
E
T
G
T
H
R
E
L
I
A
K
Q
G
A
Y
E
H
L
Y
S
I
Q
N
L
-----
80
PsiBlast_CBE
66.51
31%
-104
- C1 -
1JJ7
2
A:
[13-244]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
L
V
Q
F
Q
D
V
S
F
A
Y
P
N
R
P
-
D
V
L
V
--
L
-
Q
G
L
T
F
T
L
R
P
G
E
V
T
A
L
V
G
P
N
G
S
G
K
S
T
V
A
A
L
L
Q
N
L
Y
Q
P
T
---
G
G
Q
L
L
L
D
G
K
P
L
P
Q
Y
E
H
R
Y
L
H
R
Q
V
A
A
V
G
Q
E
P
Q
V
F
G
R
S
L
Q
E
N
I
A
Y
G
L
T
Q
-
K
---
P
-
T
M
E
E
I
T
A
A
A
V
K
S
G
A
H
S
F
I
S
G
L
P
Q
G
Y
D
T
E
V
D
E
A
G
S
Q
L
S
G
G
Q
R
Q
A
V
A
L
A
R
A
L
I
R
K
P
C
V
L
I
L
D
D
A
T
S
A
L
D
A
N
S
Q
L
Q
V
E
Q
L
L
Y
E
S
P
E
-
R
Y
S
R
S
V
L
L
I
T
Q
H
L
S
L
V
E
Q
A
D
H
I
L
F
L
E
G
G
A
I
R
E
G
G
T
H
Q
Q
L
M
E
K
K
G
C
Y
W
A
M
V
Q
A
--------
21
PsiBlast_CBE
66.48
34%
-102
- C1 -
2ONJ
4
Y1866_STAAM
B:
[260-565]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
I
V
I
G
V
G
A
Y
L
--------
A
I
S
G
S
I
T
V
G
T
L
A
A
F
V
G
Y
L
E
L
L
F
G
P
L
R
R
L
V
A
S
F
T
T
L
T
Q
S
F
A
S
M
D
R
V
F
Q
L
I
DEDYD
I
K
N
G
V
G
A
Q
-
P
------
I
----
E
--
I
K
Q
----------
G
R
I
D
I
D
H
V
S
F
Q
--
Y
N
D
-
N
E
A
P
--
I
L
K
D
I
N
L
S
I
E
K
G
E
T
V
A
F
V
G
M
S
G
G
G
K
S
T
L
I
N
L
I
P
R
F
Y
D
V
T
---
S
G
Q
I
L
I
D
G
H
N
I
K
D
F
L
T
G
S
L
R
N
Q
I
G
L
V
Q
Q
D
N
I
L
F
S
D
T
V
K
E
N
I
L
L
-
G
R
P
-
T
---
A
-
T
D
E
E
V
V
E
A
A
K
M
A
N
A
H
D
F
I
M
N
L
P
Q
G
Y
D
T
E
V
G
E
R
G
V
K
L
S
G
G
Q
K
Q
R
L
S
I
A
R
I
F
L
N
N
P
P
I
L
I
L
D
E
A
T
S
A
L
D
L
E
S
E
S
I
I
Q
E
A
L
-
D
V
L
S
-
K
-
D
R
T
T
L
I
V
A
H
R
L
S
T
I
T
H
A
D
K
I
V
V
I
E
N
G
H
I
V
E
T
G
T
H
R
E
L
I
A
K
Q
G
A
Y
E
H
L
Y
S
I
Q
N
L
-----
2
PsiBlast_PDB
66.01
34%
-100
- C1 -
2ONJ
4
Y1866_STAAM
A:
[260-565]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
I
V
I
G
V
G
A
Y
L
--------
A
I
S
G
S
I
T
V
G
T
L
A
A
F
V
G
Y
L
E
L
L
F
G
P
L
R
R
L
V
A
S
F
T
T
L
T
Q
S
F
A
S
M
D
R
V
F
Q
L
I
D
EDYD
I
K
N
G
V
G
A
Q
-
P
------
I
----
E
--
I
K
Q
----------
G
R
I
D
I
D
H
V
S
F
Q
--
Y
N
D
-
N
E
A
P
--
I
L
K
D
I
N
L
S
I
E
K
G
E
T
V
A
F
V
G
M
S
G
G
G
K
S
T
L
I
N
L
I
P
R
F
Y
D
V
T
---
S
G
Q
I
L
I
D
G
H
N
I
K
D
F
L
T
G
S
L
R
N
Q
I
G
L
V
Q
Q
D
N
I
L
F
S
D
T
V
K
E
N
I
L
L
-
G
R
P
-
T
---
A
-
T
D
E
E
V
V
E
A
A
K
M
A
N
A
H
D
F
I
M
N
L
P
Q
G
Y
D
T
E
V
G
E
R
G
V
K
L
S
G
G
Q
K
Q
R
L
S
I
A
R
I
F
L
N
N
P
P
I
L
I
L
D
E
A
T
S
A
L
D
L
E
S
E
S
I
I
Q
E
A
L
-
D
V
L
S
-
K
-
D
R
T
T
L
I
V
A
H
R
L
S
T
I
T
H
A
D
K
I
V
V
I
E
N
G
H
I
V
E
T
G
T
H
R
E
L
I
A
K
Q
G
A
Y
E
H
L
Y
S
I
Q
N
L
-----
19
PsiBlast_PDB
65.91
37%
-117
- C1 -
4Q9I
-
MDR1A_MOUSE
A:
[386-614]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
N
L
E
F
K
N
I
H
F
S
--
Y
P
S
-
R
K
E
V
QI
L
-
K
G
L
N
L
K
V
K
S
G
Q
T
V
A
L
V
G
N
S
G
C
G
K
S
T
T
V
Q
L
M
Q
R
L
Y
D
P
L
---
D
G
M
V
S
I
D
G
Q
D
I
R
T
I
N
V
R
Y
L
R
E
I
I
G
V
V
S
Q
E
P
V
L
F
A
T
T
I
A
E
N
I
R
Y
-
G
R
E
-
D
---
V
-
T
M
D
E
I
E
K
A
V
K
E
A
N
A
Y
D
F
I
M
K
L
P
H
Q
F
D
T
L
V
G
E
R
G
A
Q
L
S
G
G
Q
K
Q
R
I
A
I
A
R
A
L
V
R
N
P
K
I
L
L
L
D
E
A
T
S
A
L
D
T
E
S
E
A
V
V
Q
A
A
L
-
D
K
A
R
--
E
G
R
T
T
I
V
I
A
H
R
L
S
T
V
R
N
A
D
V
I
A
G
F
D
G
G
V
I
V
E
Q
G
N
H
D
E
L
M
R
E
K
G
I
Y
F
K
L
V
M
T
Q
T
S
F
W
R
I
L