@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : Wbm0704: (2015-12-04 )
MTKGDWEAVIGLEVHAQVSSKTKLFSSSSTEFGAEHNTQVSLVDAAMPGTLPILNYYSIEQAIRTGLALSAEINKSSYFDRKNYFYPDLPQGYQITQFFEPIVKNGRIFINNNKKEVRIARIHLEQDAGKSIHEESKTYVDLNRAGVALMEIVSEPDLRSSEEAAEFMKKLRQILRYIGSCDGDMEKGSLRCDANVSVRPKGSSTFGTRCEIKNLNSICYIMQAIDYEIQRQIEILESGEKISQDTLLFDVSLGKTKVMRNKEDASDYRYFPEPDLLPVEISQDKIDSIRSSLPELPDQKKLRYIRELSINKYDADVITSDKAIANYFEELIKKHDSKLAVTWLTVELFGRLNKAGIDIVSSPIKANALSELLDFIVDGTISARLGKQVFDIMFETGKPASLIIKEQDLKQITDKGQISEIIDKIINDNQDKVQEYQNGKTKLYGFFVGEVMKLTKGKASPDVVNFILSEKLSS
Atome Classification :
(20 SA)
.........10........20........30-........40........50........60........70........80........90........100.......110-.---.--.--......120.......130..------.------....140.......150.......160.......170.......180.......190.......200.......210.......220.......230.......240.......250.......260.......270.......280.......290.......300.......310.......320.......330.-.-.-....340.......350.......360.......370.......380.......390.......400.......410.......420.......430.......440.......450.......460.......470..--------
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MTKGD
W
E
A
V
I
G
L
E
V
H
A
Q
VSSK
T
K
LFSSSSTE-FGAEHN
T
Q
V
S
L
V
DAAMPGTL
P
I
L
N
Y
Y
S
I
E
Q
A
I
R
TG
L
A
L
S
A
EINKSSYFDRKNYFYPDLPQG
Y
Q
I
T
Q
F
F
E
P
I
VKN
G
R
I
F
I
---N---N--N--K
K
E
V
R
I
A
R
I
H
L
EQDAGK
S
I
H
E------E------S
K
T
Y
V
D
L
N
R
A
G
V
A
L
M
E
I
VSEPDLR
S
S
E
E
A
A
E
F
M
K
K
L
R
Q
I
L
R
Y
I
GSCDGDMEKG
S
L
R
CDA
N
V
S
V
RPKGSSTFG
T
R
C
E
IK
N
L
N
S
I
C
Y
I
M
Q
A
I
D
Y
E
I
Q
R
Q
I
E
I
L
ESGEKISQ
D
T
L
L
F
D
VSLG
K
T
K
V
MRNKEDASDYRYFPEPD
L
L
P
V
EIS
Q
D
K
I
D
S
I
R
S
SLPELP
D
Q
K
K
L
R
Y
I
R
E
LSINKYDADVITS
D
K
A
I
A
N
Y
F
E
E
L
I
K
-K-H-DS
K
L
A
V
T
W
L
T
V
E
L
F
G
R
L
N
KAGIDIVSSP
I
K
A
N
A
L
S
E
L
L
D
F
I
VDG
T
I
S
A
R
L
G
K
Q
V
F
D
I
M
FETGK
P
A
S
L
I
I
K
E
Q
D
L
K
Q
I
TDK
G
Q
I
S
E
I
I
D
K
I
IND
N
Q
D
K
V
Q
E
Y
QNG
K
T
K
L
Y
G
F
F
V
G
E
V
M
K
L
TKGKAS
P
D
V
V
N
F
I
L
S
E
KLSS--------
47
Fugue
94.02
44%
-88
- C2 -
3IP4
1
GATB_STAAM
B:
[1-482]
---
M
H
F
E
T
V
I
G
L
E
V
H
V
E
L
K
T
D
S
K
M
F
S
P
S
P
A
H
-
F
G
A
E
P
N
S
N
T
N
V
I
D
L
A
Y
P
G
V
L
P
V
V
N
K
R
A
V
D
W
A
M
R
A
A
M
A
L
N
M
E
I
A
T
E
S
K
F
D
R
K
N
Y
F
Y
P
D
N
P
K
A
Y
Q
I
S
Q
F
D
Q
P
I
G
E
N
G
Y
I
D
I
E
V
-
D
---
G
--
E
--
T
K
R
I
G
I
T
R
L
H
M
E
E
D
A
G
K
S
T
H
K
------
G
------
E
Y
S
L
V
D
L
N
R
Q
G
T
P
L
I
E
I
V
S
E
P
D
I
R
S
P
K
E
A
Y
A
Y
L
E
K
L
R
S
I
I
Q
Y
T
G
V
S
D
V
K
M
E
E
G
S
L
R
C
D
A
N
I
S
L
R
P
Y
G
Q
E
K
F
G
T
K
A
E
L
K
N
L
N
S
F
N
Y
V
R
K
G
L
E
Y
E
E
K
R
Q
E
E
E
L
L
N
G
G
E
I
G
Q
E
T
R
R
F
D
E
S
T
G
K
T
I
L
M
R
V
K
E
G
S
D
D
Y
R
Y
F
P
E
P
D
I
V
P
L
Y
I
D
D
A
W
K
E
R
V
R
Q
T
I
P
E
L
P
D
E
R
K
A
K
Y
V
N
E
L
G
L
P
A
Y
D
A
H
V
L
T
L
T
K
E
M
S
D
F
F
E
S
T
I
E
-
H
-
G
A
D
V
K
L
T
S
N
W
L
M
G
G
V
N
E
Y
L
N
K
N
Q
V
E
L
L
D
T
K
L
T
P
E
N
L
A
G
M
I
K
L
I
E
D
G
T
M
S
S
K
I
A
K
K
V
F
P
E
L
A
A
K
G
G
N
A
K
Q
I
M
E
D
N
G
L
V
Q
I
S
D
E
A
T
L
L
K
F
V
N
E
A
L
D
N
N
E
Q
S
V
E
D
Y
K
N
G
K
G
K
A
M
G
F
L
V
G
Q
I
M
K
A
S
K
G
Q
A
N
P
Q
L
V
N
Q
L
L
K
Q
E
L
D
K
R
LEHHHHH
35
HHSearch
93.51
44%
-87
- C2 -
3IP4
1
GATB_STAAM
B:
[1-473]
---
M
H
F
E
T
V
I
G
L
E
V
H
V
E
L
K
T
D
S
K
M
F
S
P
S
P
A
H
-
F
G
A
E
P
N
S
N
T
N
V
I
D
L
A
Y
P
G
V
L
P
V
V
N
K
R
A
V
D
W
A
M
R
A
A
M
A
L
N
M
E
I
A
T
E
S
K
F
D
R
K
N
Y
F
Y
P
D
N
P
K
A
Y
Q
I
S
Q
F
D
Q
P
I
G
E
N
G
Y
I
D
I
---
E
V
D
-
G
--
E
--
T
K
R
I
G
I
T
R
L
H
M
E
E
D
A
G
K
S
T
H
K
------
G
------
E
Y
S
L
V
D
L
N
R
Q
G
T
P
L
I
E
I
V
S
E
P
D
I
R
S
P
K
E
A
Y
A
Y
L
E
K
L
R
S
I
I
Q
Y
T
G
V
S
D
V
K
M
E
E
G
S
L
R
C
D
A
N
I
S
L
R
P
Y
G
Q
E
K
F
G
T
K
A
E
L
K
N
L
N
S
F
N
Y
V
R
K
G
L
E
Y
E
E
K
R
Q
E
E
E
L
L
N
G
G
E
I
G
Q
E
T
R
R
F
D
E
S
T
G
K
T
I
L
M
R
V
K
E
G
S
D
D
Y
R
Y
F
P
E
P
D
I
V
P
L
Y
I
D
D
A
W
K
E
R
V
R
Q
T
I
P
E
L
P
D
E
R
K
A
K
Y
V
N
E
L
G
L
P
A
Y
D
A
H
V
L
T
L
T
K
E
M
S
D
F
F
E
S
T
I
E
-
H
G
A
-
D
V
K
L
T
S
N
W
L
M
G
G
V
N
E
Y
L
N
K
N
Q
V
E
L
L
D
T
K
L
T
P
E
N
L
A
G
M
I
K
L
I
E
D
G
T
M
S
S
K
I
A
K
K
V
F
P
E
L
A
A
K
G
G
N
A
K
Q
I
M
E
D
N
G
L
V
Q
I
S
D
E
A
T
L
L
K
F
V
N
E
A
L
D
N
N
E
Q
S
V
E
D
Y
K
N
G
K
G
K
A
M
G
F
L
V
G
Q
I
M
K
A
S
K
G
Q
A
N
P
Q
L
V
N
Q
L
L
K
Q
E
L
D
K
--------
11
PsiBlast_PDB
93.00
44%
-89
- C2 -
3IP4
1
GATB_STAAM
B:
[3-472]
-----
F
E
T
V
I
G
L
E
V
H
V
E
L
K
T
D
S
K
M
F
S
P
S
P
A
H
-
F
G
A
E
P
N
S
N
T
N
V
I
D
L
A
Y
P
G
V
L
P
V
V
N
K
R
A
V
D
W
A
M
R
A
A
M
A
L
N
M
E
I
A
T
E
S
K
F
D
R
K
N
Y
F
Y
P
D
N
P
K
A
Y
Q
I
S
Q
F
D
Q
P
I
G
E
N
G
Y
I
D
I
E
V
-
D
---
G
--
E
--
T
K
R
I
G
I
T
R
L
H
M
E
E
D
A
G
K
S
T
H
K
------
G
------
E
Y
S
L
V
D
L
N
R
Q
G
T
P
L
I
E
I
V
S
E
P
D
I
R
S
P
K
E
A
Y
A
Y
L
E
K
L
R
S
I
I
Q
Y
T
G
V
S
D
V
K
M
E
E
G
S
L
R
C
D
A
N
I
S
L
R
P
Y
G
Q
E
K
F
G
T
K
A
E
L
K
N
L
N
S
F
N
Y
V
R
K
G
L
E
Y
E
E
K
R
Q
E
E
E
L
L
N
G
G
E
I
G
Q
E
T
R
R
F
D
E
S
T
G
K
T
I
L
M
R
V
K
E
G
S
D
D
Y
R
Y
F
P
E
P
D
I
V
P
L
Y
I
D
D
A
W
K
E
R
V
R
Q
T
I
P
E
L
P
D
E
R
K
A
K
Y
V
N
E
L
G
L
P
A
Y
D
A
H
V
L
T
L
T
K
E
M
S
D
F
F
E
S
T
I
E
-
H
G
A
-
D
V
K
L
T
S
N
W
L
M
G
G
V
N
E
Y
L
N
K
N
Q
V
E
L
L
D
T
K
L
T
P
E
N
L
A
G
M
I
K
L
I
E
D
G
T
M
S
S
K
I
A
K
K
V
F
P
E
L
A
A
K
G
G
N
A
K
Q
I
M
E
D
N
G
L
V
Q
I
S
D
E
A
T
L
L
K
F
V
N
E
A
L
D
N
N
E
Q
S
V
E
D
Y
K
N
G
K
G
K
A
M
G
F
L
V
G
Q
I
M
K
A
S
K
G
Q
A
N
P
Q
L
V
N
Q
L
L
K
Q
E
L
D
K
--------
45
Fugue
90.12
50%
-91
- C2 -
3H0L
2
GATB_AQUAE
B:
[3-412]
---
E
K
Y
E
A
V
I
G
L
E
I
H
V
Q
M
D
T
K
T
K
M
F
C
G
C
K
V
E
-
F
G
A
E
P
N
T
N
V
C
P
V
C
L
G
M
P
G
A
L
P
I
V
N
K
R
A
V
E
Y
A
I
R
A
S
L
A
L
N
C
E
V
H
E
E
S
V
F
A
R
K
H
Y
F
Y
P
D
L
P
K
G
Y
Q
I
S
Q
Y
E
K
P
L
A
T
N
G
W
V
E
L
N
L
P
N
---
G
--
E
--
K
K
K
V
R
I
R
R
L
H
I
E
E
D
A
G
K
N
I
H
E
------
G
------
D
K
T
L
V
D
L
N
R
A
G
T
P
L
M
E
I
V
T
E
P
D
I
R
T
P
E
E
A
R
L
F
L
E
K
L
R
N
I
M
R
Y
A
G
V
S
K
A
D
M
E
K
G
Q
L
R
C
D
I
N
V
S
I
R
P
K
G
S
K
E
F
G
T
R
V
E
I
K
N
V
N
S
F
R
F
V
Q
K
A
L
E
Y
E
I
E
R
Q
I
N
V
V
E
E
G
G
E
V
V
Q
E
T
R
T
F
D
P
Q
T
G
K
T
Y
P
M
R
T
K
E
E
A
E
D
Y
R
Y
F
P
D
P
D
L
V
P
L
K
V
K
K
E
W
I
E
E
I
K
K
N
M
P
E
L
P
D
Q
R
F
E
R
L
I
K
E
Y
G
L
S
E
Y
E
A
G
I
L
V
N
H
K
E
V
G
D
F
F
E
E
A
V
R
-
H
F
K
-
E
P
K
G
I
V
N
W
L
I
N
D
L
L
G
L
L
R
D
K
G
I
S
I
E
E
S
P
V
K
P
E
H
L
A
E
L
V
K
L
I
K
E
K
V
I
S
T
K
I
G
K
E
V
I
K
E
M
V
E
T
G
K
T
P
S
Q
I
V
E
E
K
G
L
-------------------------------------------------------------------------
36
HHSearch
89.73
50%
-89
- C2 -
3H0L
2
GATB_AQUAE
B:
[3-412]
---
E
K
Y
E
A
V
I
G
L
E
I
H
V
Q
M
D
T
K
T
K
M
F
C
G
C
K
V
E
-
F
G
A
E
P
N
T
N
V
C
P
V
C
L
G
M
P
G
A
L
P
I
V
N
K
R
A
V
E
Y
A
I
R
A
S
L
A
L
N
C
E
V
H
E
E
S
V
F
A
R
K
H
Y
F
Y
P
D
L
P
K
G
Y
Q
I
S
Q
Y
E
K
P
L
A
T
N
G
W
V
E
L
---
N
L
PN
G
--
E
--
K
K
K
V
R
I
R
R
L
H
I
E
E
D
A
G
K
N
I
H
E
------
G
------
D
K
T
L
V
D
L
N
R
A
G
T
P
L
M
E
I
V
T
E
P
D
I
R
T
P
E
E
A
R
L
F
L
E
K
L
R
N
I
M
R
Y
A
G
V
S
K
A
D
M
E
K
G
Q
L
R
C
D
I
N
V
S
I
R
P
K
G
S
K
E
F
G
T
R
V
E
I
K
N
V
N
S
F
R
F
V
Q
K
A
L
E
Y
E
I
E
R
Q
I
N
V
V
E
E
G
G
E
V
V
Q
E
T
R
T
F
D
P
Q
T
G
K
T
Y
P
M
R
T
K
E
E
A
E
D
Y
R
Y
F
P
D
P
D
L
V
P
L
K
V
K
K
E
W
I
E
E
I
K
K
N
M
P
E
L
P
D
Q
R
F
E
R
L
I
K
E
Y
G
L
S
E
Y
E
A
G
I
L
V
N
H
K
E
V
G
D
F
F
E
E
A
V
R
-
H
F
K
-
E
P
K
G
I
V
N
W
L
I
N
D
L
L
G
L
L
R
D
K
G
I
S
I
E
E
S
P
V
K
P
E
H
L
A
E
L
V
K
L
I
K
E
K
V
I
S
T
K
I
G
K
E
V
I
K
E
M
V
E
T
G
K
T
P
S
Q
I
V
E
E
K
G
L
-------------------------------------------------------------------------
1
PsiBlast_PDB
89.32
50%
-90
- C2 -
3H0L
2
GATB_AQUAE
B:
[5-412]
-----
Y
E
A
V
I
G
L
E
I
H
V
Q
M
D
T
K
T
K
M
F
C
G
C
K
V
E
-
F
G
A
E
P
N
T
N
V
C
P
V
C
L
G
M
P
G
A
L
P
I
V
N
K
R
A
V
E
Y
A
I
R
A
S
L
A
L
N
C
E
V
H
E
E
S
V
F
A
R
K
H
Y
F
Y
P
D
L
P
K
G
Y
Q
I
S
Q
Y
E
K
P
L
A
T
N
G
W
V
E
L
---
N
L
PN
G
--
E
--
K
K
K
V
R
I
R
R
L
H
I
E
E
D
A
G
K
N
I
H
E
------
G
------
D
K
T
L
V
D
L
N
R
A
G
T
P
L
M
E
I
V
T
E
P
D
I
R
T
P
E
E
A
R
L
F
L
E
K
L
R
N
I
M
R
Y
A
G
V
S
K
A
D
M
E
K
G
Q
L
R
C
D
I
N
V
S
I
R
P
K
G
S
K
E
F
G
T
R
V
E
I
K
N
V
N
S
F
R
F
V
Q
K
A
L
E
Y
E
I
E
R
Q
I
N
V
V
E
E
G
G
E
V
V
Q
E
T
R
T
F
D
P
Q
T
G
K
T
Y
P
M
R
T
K
E
E
A
E
D
Y
R
Y
F
P
D
P
D
L
V
P
L
K
V
K
K
E
W
I
E
E
I
K
K
N
M
P
E
L
P
D
Q
R
F
E
R
L
I
K
E
Y
G
L
S
E
Y
E
A
G
I
L
V
N
H
K
E
V
G
D
F
F
E
E
A
V
R
-
H
F
K
-
E
P
K
G
I
V
N
W
L
I
N
D
L
L
G
L
L
R
D
K
G
I
S
I
E
E
S
P
V
K
P
E
H
L
A
E
L
V
K
L
I
K
E
K
V
I
S
T
K
I
G
K
E
V
I
K
E
M
V
E
T
G
K
T
P
S
Q
I
V
E
E
K
G
L
-------------------------------------------------------------------------
34
PsiBlast_CBE
89.14
50%
-88
- C2 -
3H0L
30
GATB_AQUAE
W:
[5-412]
-----
Y
E
A
V
I
G
L
E
I
H
V
Q
M
D
T
K
T
K
M
F
C
G
C
K
V
E
-
F
G
A
E
P
N
T
N
V
C
P
V
C
L
G
M
P
G
A
L
P
I
V
N
K
R
A
V
E
Y
A
I
R
A
S
L
A
L
N
C
E
V
H
E
E
S
V
F
A
R
K
H
Y
F
Y
P
D
L
P
K
G
Y
Q
I
S
Q
Y
E
K
P
L
A
T
N
G
W
V
E
L
---
N
LPN
G
--
E
--
K
K
K
V
R
I
R
R
L
H
I
E
E
D
A
G
K
N
I
H
E
------
G
------
D
K
T
L
V
D
L
N
R
A
G
T
P
L
M
E
I
V
T
E
P
D
I
R
T
P
E
E
A
R
L
F
L
E
K
L
R
N
I
M
R
Y
A
G
V
S
K
A
D
M
E
K
G
Q
L
R
C
D
I
N
V
S
I
R
P
K
G
S
K
E
F
G
T
R
V
E
I
K
N
V
N
S
F
R
F
V
Q
K
A
L
E
Y
E
I
E
R
Q
I
N
V
V
E
E
G
G
E
V
V
Q
E
T
R
T
F
D
P
Q
T
G
K
T
Y
P
M
R
T
K
E
E
A
E
D
Y
R
Y
F
P
D
P
D
L
V
P
L
K
V
K
K
E
W
I
E
E
I
K
K
N
M
P
E
L
P
D
Q
R
F
E
R
L
I
K
E
Y
G
L
S
E
Y
E
A
G
I
L
V
N
H
K
E
V
G
D
F
F
E
E
A
V
R
-
H
F
K
-
E
P
K
G
I
V
N
W
L
I
N
D
L
L
G
L
L
R
D
K
G
I
S
I
E
E
S
P
V
K
P
E
H
L
A
E
L
V
K
L
I
K
E
K
V
I
S
T
K
I
G
K
E
V
I
K
E
M
V
E
T
G
K
T
P
S
Q
I
V
E
E
K
G
L
-------------------------------------------------------------------------
27
PsiBlast_CBE
88.98
50%
-89
- C2 -
3H0M
21
GATB_AQUAE
W:
[5-412]
-----
Y
E
A
V
I
G
L
E
I
H
V
Q
M
D
T
K
T
K
M
F
C
G
C
K
V
E
-
F
G
A
E
P
N
T
N
V
C
P
V
C
L
G
M
P
G
A
L
P
I
V
N
K
R
A
V
E
Y
A
I
R
A
S
L
A
L
N
C
E
V
H
E
E
S
V
F
A
R
K
H
Y
F
Y
P
D
L
P
K
G
Y
Q
I
S
Q
Y
E
K
P
L
A
T
N
G
W
V
E
L
---
N
LPN
G
--
E
--
K
K
K
V
R
I
R
R
L
H
I
E
E
D
A
G
K
N
I
H
E
------
G
------
D
K
T
L
V
D
L
N
R
A
G
T
P
L
M
E
I
V
T
E
P
D
I
R
T
P
E
E
A
R
L
F
L
E
K
L
R
N
I
M
R
Y
A
G
V
S
K
A
D
M
E
K
G
Q
L
R
C
D
I
N
V
S
I
R
P
K
G
S
K
E
F
G
T
R
V
E
I
K
N
V
N
S
F
R
F
V
Q
K
A
L
E
Y
E
I
E
R
Q
I
N
V
V
E
E
G
G
E
V
V
Q
E
T
R
T
F
D
P
Q
T
G
K
T
Y
P
M
R
T
K
E
E
A
E
D
Y
R
Y
F
P
D
P
D
L
V
P
L
K
V
K
K
E
W
I
E
E
I
K
K
N
M
P
E
L
P
D
Q
R
F
E
R
L
I
K
E
Y
G
L
S
E
Y
E
A
G
I
L
V
N
H
K
E
V
G
D
F
F
E
E
A
V
R
-
H
F
K
-
E
P
K
G
I
V
N
W
L
I
N
D
L
L
G
L
L
R
D
K
G
I
S
I
E
E
S
P
V
K
P
E
H
L
A
E
L
V
K
L
I
K
E
K
V
I
S
T
K
I
G
K
E
V
I
K
E
M
V
E
T
G
K
T
P
S
Q
I
V
E
E
K
G
L
-------------------------------------------------------------------------
2
PsiBlast_PDB
88.85
50%
-89
- C2 -
3H0M
-
GATB_AQUAE
B:
[5-412]
-----
Y
E
A
V
I
G
L
E
I
H
V
Q
M
D
T
K
T
K
M
F
C
G
C
K
V
E
-
F
G
A
E
P
N
T
N
V
C
P
V
C
L
G
M
P
G
A
L
P
I
V
N
K
R
A
V
E
Y
A
I
R
A
S
L
A
L
N
C
E
V
H
E
E
S
V
F
A
R
K
H
Y
F
Y
P
D
L
P
K
G
Y
Q
I
S
Q
Y
E
K
P
L
A
T
N
G
W
V
E
L
---
N
L
PN
G
--
E
--
K
K
K
V
R
I
R
R
L
H
I
E
E
D
A
G
K
N
I
H
E
------
G
------
D
K
T
L
V
D
L
N
R
A
G
T
P
L
M
E
I
V
T
E
P
D
I
R
T
P
E
E
A
R
L
F
L
E
K
L
R
N
I
M
R
Y
A
G
V
S
K
A
D
M
E
K
G
Q
L
R
C
D
I
N
V
S
I
R
P
K
G
S
K
E
F
G
T
R
V
E
I
K
N
V
N
S
F
R
F
V
Q
K
A
L
E
Y
E
I
E
R
Q
I
N
V
V
E
E
G
G
E
V
V
Q
E
T
R
T
F
D
P
Q
T
G
K
T
Y
P
M
R
T
K
E
E
A
E
D
Y
R
Y
F
P
D
P
D
L
V
P
L
K
V
K
K
E
W
I
E
E
I
K
K
N
M
P
E
L
P
D
Q
R
F
E
R
L
I
K
E
Y
G
L
S
E
Y
E
A
G
I
L
V
N
H
K
E
V
G
D
F
F
E
E
A
V
R
-
H
F
K
-
E
P
K
G
I
V
N
W
L
I
N
D
L
L
G
L
L
R
D
K
G
I
S
I
E
E
S
P
V
K
P
E
H
L
A
E
L
V
K
L
I
K
E
K
V
I
S
T
K
I
G
K
E
V
I
K
E
M
V
E
T
G
K
T
P
S
Q
I
V
E
E
K
G
L
-------------------------------------------------------------------------
20
PsiBlast_CBE
88.74
50%
-89
- C2 -
3H0R
32
GATB_AQUAE
W:
[5-412]
-----
Y
E
A
V
I
G
L
E
I
H
V
Q
M
D
T
K
T
K
M
F
C
G
C
K
V
E
-
F
G
A
E
P
N
T
N
V
C
P
V
C
L
G
M
P
G
A
L
P
I
V
N
K
R
A
V
E
Y
A
I
R
A
S
L
A
L
N
C
E
V
H
E
E
S
V
F
A
R
K
H
Y
F
Y
P
D
L
P
K
G
Y
Q
I
S
Q
Y
E
K
P
L
A
T
N
G
W
V
E
L
---
N
LPN
G
--
E
--
K
K
K
V
R
I
R
R
L
H
I
E
E
D
A
G
K
N
I
H
E
------
G
------
D
K
T
L
V
D
L
N
R
A
G
T
P
L
M
E
I
V
T
E
P
D
I
R
T
P
E
E
A
R
L
F
L
E
K
L
R
N
I
M
R
Y
A
G
V
S
K
A
D
M
E
K
G
Q
L
R
C
D
I
N
V
S
I
R
P
K
G
S
K
E
F
G
T
R
V
E
I
K
N
V
N
S
F
R
F
V
Q
K
A
L
E
Y
E
I
E
R
Q
I
N
V
V
E
E
G
G
E
V
V
Q
E
T
R
T
F
D
P
Q
T
G
K
T
Y
P
M
R
T
K
E
E
A
E
D
Y
R
Y
F
P
D
P
D
L
V
P
L
K
V
K
K
E
W
I
E
E
I
K
K
N
M
P
E
L
P
D
Q
R
F
E
R
L
I
K
E
Y
G
L
S
E
Y
E
A
G
I
L
V
N
H
K
E
V
G
D
F
F
E
E
A
V
R
-
H
F
K
-
E
P
K
G
I
V
N
W
L
I
N
D
L
L
G
L
L
R
D
K
G
I
S
I
E
E
S
P
V
K
P
E
H
L
A
E
L
V
K
L
I
K
E
K
V
I
S
T
K
I
G
K
E
V
I
K
E
M
V
E
T
G
K
T
P
S
Q
I
V
E
E
K
G
L
-------------------------------------------------------------------------
37
HHSearch
88.34
45%
-85
- C2 -
3AL0
1
GATB_THEMA
B:
[1-481]
---
M
R
Y
R
P
V
I
G
L
E
I
H
V
Q
L
S
T
K
T
K
A
F
C
S
C
P
A
D
V
F
E
L
P
P
N
T
A
I
C
P
V
C
T
G
Q
P
G
A
L
P
V
P
N
E
E
M
I
R
F
A
V
K
T
A
L
A
L
N
C
K
I
H
K
Y
S
R
F
D
R
K
N
Y
F
Y
P
D
L
P
K
G
Y
Q
I
S
Q
Y
F
Y
P
I
A
T
E
G
F
L
E
I
---
D
---
G
DE
G
--
R
K
K
V
R
I
R
R
L
H
L
E
E
D
A
G
K
L
V
H
E
------
G
DSITRA
S
Y
S
L
V
D
M
N
R
C
G
V
P
L
I
E
I
V
T
E
P
D
I
S
S
P
R
E
A
R
V
F
M
E
K
L
R
S
I
V
R
Y
L
G
V
S
T
G
D
M
E
K
G
A
L
R
C
D
A
N
I
S
V
V
D
T
E
T
G
R
Q
S
N
R
V
E
V
K
N
M
N
S
F
R
F
V
E
R
A
L
E
Y
E
F
E
R
I
V
K
A
M
E
R
G
E
D
V
E
R
E
T
R
G
W
D
M
A
T
K
I
T
V
S
M
R
G
K
E
E
E
S
D
Y
R
Y
F
P
E
P
D
I
P
P
V
V
L
S
D
E
Y
L
E
E
V
K
K
E
L
P
E
L
P
D
E
K
A
E
R
F
M
R
E
Y
G
L
P
E
Y
D
A
K
V
L
T
S
S
K
E
L
A
E
F
F
E
E
C
V
K
-
V
V
N
-
R
P
K
D
L
S
N
W
I
M
T
E
V
L
R
E
L
N
E
R
N
I
E
I
T
E
S
K
L
T
P
Q
H
F
A
D
L
F
K
L
M
D
E
G
K
I
S
I
K
I
A
K
E
I
F
P
E
V
F
E
T
G
K
M
P
S
Q
I
V
E
E
K
G
L
T
Q
I
N
D
E
K
L
I
E
E
L
V
K
K
A
M
E
Q
N
P
K
A
V
Q
D
Y
K
S
G
K
K
K
A
A
G
F
F
V
G
Y
V
M
R
E
T
K
G
K
A
N
P
E
L
T
N
R
I
I
Q
K
L
L
E
G
--------
3
PsiBlast_PDB
88.22
50%
-87
- C2 -
3H0R
-
GATB_AQUAE
B:
[5-412]
-----
Y
E
A
V
I
G
L
E
I
H
V
Q
M
D
T
K
T
K
M
F
C
G
C
K
V
E
-
F
G
A
E
P
N
T
N
V
C
P
V
C
L
G
M
P
G
A
L
P
I
V
N
K
R
A
V
E
Y
A
I
R
A
S
L
A
L
N
C
E
V
H
E
E
S
V
F
A
R
K
H
Y
F
Y
P
D
L
P
K
G
Y
Q
I
S
Q
Y
E
K
P
L
A
T
N
G
W
V
E
L
---
N
L
PN
G
--
E
--
K
K
K
V
R
I
R
R
L
H
I
E
E
D
A
G
K
N
I
H
E
------
G
------
D
K
T
L
V
D
L
N
R
A
G
T
P
L
M
E
I
V
T
E
P
D
I
R
T
P
E
E
A
R
L
F
L
E
K
L
R
N
I
M
R
Y
A
G
V
S
K
A
D
M
E
K
G
Q
L
R
C
D
I
N
V
S
I
R
P
K
G
S
K
E
F
G
T
R
V
E
I
K
N
V
N
S
F
R
F
V
Q
K
A
L
E
Y
E
I
E
R
Q
I
N
V
V
E
E
G
G
E
V
V
Q
E
T
R
T
F
D
P
Q
T
G
K
T
Y
P
M
R
T
K
E
E
A
E
D
Y
R
Y
F
P
D
P
D
L
V
P
L
K
V
K
K
E
W
I
E
E
I
K
K
N
M
P
E
L
P
D
Q
R
F
E
R
L
I
K
E
Y
G
L
S
E
Y
E
A
G
I
L
V
N
H
K
E
V
G
D
F
F
E
E
A
V
R
-
H
F
K
-
E
P
K
G
I
V
N
W
L
I
N
D
L
L
G
L
L
R
D
K
G
I
S
I
E
E
S
P
V
K
P
E
H
L
A
E
L
V
K
L
I
K
E
K
V
I
S
T
K
I
G
K
E
V
I
K
E
M
V
E
T
G
K
T
P
S
Q
I
V
E
E
K
G
L
-------------------------------------------------------------------------
4
PsiBlast_PDB
87.45
44%
-84
- C2 -
3AL0
1
GATB_THEMA
B:
[3-479]
-----
Y
R
P
V
I
G
L
E
I
H
V
Q
L
S
T
K
T
K
A
F
C
S
C
P
A
D
V
F
E
L
P
P
N
T
A
I
C
P
V
C
T
G
Q
P
G
A
L
P
V
P
N
E
E
M
I
R
F
A
V
K
T
A
L
A
L
N
C
K
I
H
K
Y
S
R
F
D
R
K
N
Y
F
Y
P
D
L
P
K
G
Y
Q
I
S
Q
Y
F
Y
P
I
A
T
E
G
F
L
E
I
---
D
---
G
--
D
EG
R
K
K
V
R
I
R
R
L
H
L
E
E
D
A
G
K
L
V
H
E
GDSITR
A
------
S
Y
S
L
V
D
M
N
R
C
G
V
P
L
I
E
I
V
T
E
P
D
I
S
S
P
R
E
A
R
V
F
M
E
K
L
R
S
I
V
R
Y
L
G
V
S
T
G
D
M
E
K
G
A
L
R
C
D
A
N
I
S
V
V
D
T
E
T
G
R
Q
S
N
R
V
E
V
K
N
M
N
S
F
R
F
V
E
R
A
L
E
Y
E
F
E
R
I
V
K
A
M
E
R
G
E
D
V
E
R
E
T
R
G
W
D
M
A
T
K
I
T
V
S
M
R
G
K
E
E
E
S
D
Y
R
Y
F
P
E
P
D
I
P
P
V
V
L
S
D
E
Y
L
E
E
V
K
K
E
L
P
E
L
P
D
E
K
A
E
R
F
M
R
E
Y
G
L
P
E
Y
D
A
K
V
L
T
S
S
K
E
L
A
E
F
F
E
E
C
V
K
V
V
-
N
-
R
P
K
D
L
S
N
W
I
M
T
E
V
L
R
E
L
N
E
R
N
I
E
I
T
E
S
K
L
T
P
Q
H
F
A
D
L
F
K
L
M
D
E
G
K
I
S
I
K
I
A
K
E
I
F
P
E
V
F
E
T
G
K
M
P
S
Q
I
V
E
E
K
G
L
T
Q
I
N
D
E
K
L
I
E
E
L
V
K
K
A
M
E
Q
N
P
K
A
V
Q
D
Y
K
S
G
K
K
K
A
A
G
F
F
V
G
Y
V
M
R
E
T
K
G
K
A
N
P
E
L
T
N
R
I
I
Q
K
L
L
E
G
--------
10
PsiBlast_PDB
82.82
44%
-84
- C2 -
2G5I
2
GATB_STAAM
B:
[3-411]
-----
F
E
T
V
I
G
L
E
V
H
V
E
L
K
T
D
S
K
M
F
S
P
S
P
A
H
-
F
G
A
E
P
N
S
N
T
N
V
I
D
L
A
Y
P
G
V
L
P
V
V
N
K
R
A
V
D
W
A
M
R
A
A
M
A
L
N
M
E
I
A
T
E
S
K
F
D
R
K
N
Y
F
Y
P
D
N
P
K
A
Y
Q
I
S
Q
F
D
Q
P
I
G
E
N
G
Y
I
D
I
E
V
-
D
---
G
--
E
--
T
K
R
I
G
I
T
R
L
H
M
E
E
D
A
G
K
S
T
H
K
------
G
------
E
Y
S
L
V
D
L
N
R
Q
G
T
P
L
I
E
I
V
S
E
P
D
I
R
S
P
K
E
A
Y
A
Y
L
E
K
L
R
S
I
I
Q
Y
T
G
V
S
D
V
K
M
E
E
G
S
L
R
C
D
A
N
I
S
L
R
P
Y
G
Q
E
K
F
G
T
K
A
E
L
K
N
L
N
S
F
N
Y
V
R
K
G
L
E
Y
E
E
K
R
Q
E
E
E
L
L
N
G
G
E
I
G
Q
E
T
R
R
F
D
E
S
T
G
K
T
I
L
M
R
V
K
E
G
S
D
D
Y
R
Y
F
P
E
P
D
I
V
P
L
Y
I
D
D
A
W
K
E
R
V
R
Q
T
I
P
E
L
P
D
E
R
K
A
K
Y
V
N
E
L
G
L
P
A
Y
D
A
H
V
L
T
L
T
K
E
M
S
D
F
F
E
S
T
I
E
-
H
G
A
-
D
V
K
L
T
S
N
W
L
M
G
G
V
N
E
Y
L
N
K
N
Q
V
E
L
L
D
T
K
L
T
P
E
N
L
A
G
M
I
K
L
I
E
D
G
T
M
S
S
K
I
A
K
K
V
F
P
E
L
A
A
K
G
G
N
A
K
Q
I
M
E
D
N
G
L
V
Q
-----------------------------------------------------------------------
46
Fugue
81.94
45%
-83
* C2 *
2F2A
1
GATB_STAAM
B:
[4-411]
------
E
T
V
I
G
L
E
V
H
V
E
L
K
T
D
S
K
M
F
S
P
S
P
A
H
-
F
G
A
E
P
N
S
N
T
N
V
I
D
L
A
Y
P
G
V
L
P
V
V
N
K
R
A
V
D
W
A
M
R
A
A
M
A
L
N
M
E
I
A
T
E
S
K
F
D
R
K
N
Y
F
Y
P
D
N
P
K
A
Y
Q
I
S
Q
F
D
Q
P
I
G
E
N
G
Y
I
D
I
---
E
V
D-
G
--
E
--
T
K
R
I
G
I
T
R
L
H
M
E
E
D
A
G
K
S
T
H
K
------
G
------
E
Y
S
L
V
D
L
N
R
Q
G
T
P
L
I
E
I
V
S
E
P
D
I
R
S
P
K
E
A
Y
A
Y
L
E
K
L
R
S
I
I
Q
Y
T
G
V
S
D
V
K
M
E
E
G
S
L
R
C
D
A
N
I
S
L
R
P
Y
G
Q
E
K
F
G
T
K
A
E
L
K
N
L
N
S
F
N
Y
V
R
K
G
L
E
Y
E
E
K
R
Q
E
E
E
L
L
N
G
G
E
I
G
Q
E
T
R
R
F
D
E
S
T
G
K
T
I
L
M
R
V
K
E
G
S
D
D
Y
R
Y
F
P
E
P
D
I
V
P
L
Y
I
D
D
A
W
K
E
R
V
R
Q
T
I
P
E
L
P
D
E
R
K
A
K
Y
V
N
E
L
G
L
P
A
Y
D
A
H
V
L
T
L
T
K
E
M
S
D
F
F
E
S
T
I
E
-
H
-
G
A
D
V
K
L
T
S
N
W
L
M
G
G
V
N
E
Y
L
N
K
N
Q
V
E
L
L
D
T
K
L
T
P
E
N
L
A
G
M
I
K
L
I
E
D
G
T
M
S
S
K
I
A
K
K
V
F
P
E
L
A
A
K
G
G
N
A
K
Q
I
M
E
D
N
G
L
V
Q
-----------------------------------------------------------------------
8
PsiBlast_PDB
81.83
44%
-83
- C2 -
2F2A
1
GATB_STAAM
B:
[4-411]
------
E
T
V
I
G
L
E
V
H
V
E
L
K
T
D
S
K
M
F
S
P
S
P
A
H
-
F
G
A
E
P
N
S
N
T
N
V
I
D
L
A
Y
P
G
V
L
P
V
V
N
K
R
A
V
D
W
A
M
R
A
A
M
A
L
N
M
E
I
A
T
E
S
K
F
D
R
K
N
Y
F
Y
P
D
N
P
K
A
Y
Q
I
S
Q
F
D
Q
P
I
G
E
N
G
Y
I
D
I
E
V
-
D
---
G
--
E
--
T
K
R
I
G
I
T
R
L
H
M
E
E
D
A
G
K
S
T
H
K
------
G
------
E
Y
S
L
V
D
L
N
R
Q
G
T
P
L
I
E
I
V
S
E
P
D
I
R
S
P
K
E
A
Y
A
Y
L
E
K
L
R
S
I
I
Q
Y
T
G
V
S
D
V
K
M
E
E
G
S
L
R
C
D
A
N
I
S
L
R
P
Y
G
Q
E
K
F
G
T
K
A
E
L
K
N
L
N
S
F
N
Y
V
R
K
G
L
E
Y
E
E
K
R
Q
E
E
E
L
L
N
G
G
E
I
G
Q
E
T
R
R
F
D
E
S
T
G
K
T
I
L
M
R
V
K
E
G
S
D
D
Y
R
Y
F
P
E
P
D
I
V
P
L
Y
I
D
D
A
W
K
E
R
V
R
Q
T
I
P
E
L
P
D
E
R
K
A
K
Y
V
N
E
L
G
L
P
A
Y
D
A
H
V
L
T
L
T
K
E
M
S
D
F
F
E
S
T
I
E
-
H
G
A
-
D
V
K
L
T
S
N
W
L
M
G
G
V
N
E
Y
L
N
K
N
Q
V
E
L
L
D
T
K
L
T
P
E
N
L
A
G
M
I
K
L
I
E
D
G
T
M
S
S
K
I
A
K
K
V
F
P
E
L
A
A
K
G
G
N
A
K
Q
I
M
E
D
N
G
L
V
Q
-----------------------------------------------------------------------
7
PsiBlast_PDB
81.53
44%
-79
- C2 -
2DQN
1
GATB_STAAM
B:
[3-407]
-----
F
E
T
V
I
G
L
E
V
H
V
E
L
K
T
D
S
K
M
F
S
P
S
P
A
H
-
F
G
A
E
P
N
S
N
T
N
V
I
D
L
A
Y
P
G
V
L
P
V
V
N
K
R
A
V
D
W
A
M
R
A
A
M
A
L
N
M
E
I
A
T
E
S
K
F
D
R
K
N
Y
F
Y
P
D
N
P
K
A
Y
Q
I
S
Q
F
D
Q
P
I
G
E
N
G
Y
I
D
I
E
V
-
D
---
G
--
E
--
T
K
R
I
G
I
T
R
L
H
M
E
E
D
A
G
K
S
T
H
K
------
G
------
E
Y
S
L
V
D
L
N
R
Q
G
T
P
L
I
E
I
V
S
E
P
D
I
R
S
P
K
E
A
Y
A
Y
L
E
K
L
R
S
I
I
Q
Y
T
G
V
S
D
V
K
M
E
E
G
S
L
R
C
D
A
N
I
S
L
R
P
Y
G
Q
E
K
F
G
T
K
A
E
L
K
N
L
N
S
F
N
Y
V
R
K
G
L
E
Y
E
E
K
R
Q
E
E
E
L
L
N
G
G
E
I
G
Q
E
T
R
R
F
D
E
S
T
G
K
T
I
L
M
R
V
K
E
G
S
D
D
Y
R
Y
F
P
E
P
D
I
V
P
L
Y
I
D
D
A
W
K
E
R
V
R
Q
T
I
P
E
L
P
D
E
R
K
A
K
Y
V
N
E
L
G
L
P
A
Y
D
A
H
V
L
T
L
T
K
E
M
S
D
F
F
E
S
T
I
E
-
H
G
A
-
D
V
K
L
T
S
N
W
L
M
G
G
V
N
E
Y
L
N
K
N
Q
V
E
L
L
D
T
K
L
T
P
E
N
L
A
G
M
I
K
L
I
E
D
G
T
M
S
S
K
I
A
K
K
V
F
P
E
L
A
A
K
G
G
N
A
K
Q
I
M
E
D
N
---------------------------------------------------------------------------
9
PsiBlast_PDB
81.01
44%
-78
- C2 -
2G5H
1
GATB_STAAM
B:
[3-400]
-----
F
E
T
V
I
G
L
E
V
H
V
E
L
K
T
D
S
K
M
F
S
P
S
P
A
H
-
F
G
A
E
P
N
S
N
T
N
V
I
D
L
A
Y
P
G
V
L
P
V
V
N
K
R
A
V
D
W
A
M
R
A
A
M
A
L
N
M
E
I
A
T
E
S
K
F
D
R
K
N
Y
F
Y
P
D
N
P
K
A
Y
Q
I
S
Q
F
D
Q
P
I
G
E
N
G
Y
I
D
I
E
V
-
D
---
G
--
E
--
T
K
R
I
G
I
T
R
L
H
M
E
E
D
A
G
K
S
T
H
K
------
G
------
E
Y
S
L
V
D
L
N
R
Q
G
T
P
L
I
E
I
V
S
E
P
D
I
R
S
P
K
E
A
Y
A
Y
L
E
K
L
R
S
I
I
Q
Y
T
G
V
S
D
V
K
M
E
E
G
S
L
R
C
D
A
N
I
S
L
R
P
Y
G
Q
E
K
F
G
T
K
A
E
L
K
N
L
N
S
F
N
Y
V
R
K
G
L
E
Y
E
E
K
R
Q
E
E
E
L
L
N
G
G
E
I
G
Q
E
T
R
R
F
D
E
S
T
G
K
T
I
L
M
R
V
K
E
G
S
D
D
Y
R
Y
F
P
E
P
D
I
V
P
L
Y
I
D
D
A
W
K
E
R
V
R
Q
T
I
P
E
L
P
D
E
R
K
A
K
Y
V
N
E
L
G
L
P
A
Y
D
A
H
V
L
T
L
T
K
E
M
S
D
F
F
E
S
T
I
E
-
H
G
A
-
D
V
K
L
T
S
N
W
L
M
G
G
V
N
E
Y
L
N
K
N
Q
V
E
L
L
D
T
K
L
T
P
E
N
L
A
G
M
I
K
L
I
E
D
G
T
M
S
S
K
I
A
K
K
V
F
P
E
L
A
A
K
G
G
N
A
----------------------------------------------------------------------------------
6
PsiBlast_PDB
80.13
44%
-80
- C2 -
2DF4
2
GATB_STAAM
B:
[3-400]
-----
F
E
T
V
I
G
L
E
V
H
V
E
L
K
T
D
S
K
M
F
S
P
S
P
A
H
-
F
G
A
E
P
N
S
N
T
N
V
I
D
L
A
Y
P
G
V
L
P
V
V
N
K
R
A
V
D
W
A
M
R
A
A
M
A
L
N
M
E
I
A
T
E
S
K
F
D
R
K
N
Y
F
Y
P
D
N
P
K
A
Y
Q
I
S
Q
F
D
Q
P
I
G
E
N
G
Y
I
D
I
E
V
-
D
---
G
--
E
--
T
K
R
I
G
I
T
R
L
H
M
E
E
D
A
G
K
S
T
H
K
------
G
------
E
Y
S
L
V
D
L
N
R
Q
G
T
P
L
I
E
I
V
S
E
P
D
I
R
S
P
K
E
A
Y
A
Y
L
E
K
L
R
S
I
I
Q
Y
T
G
V
S
D
V
K
M
E
E
G
S
L
R
C
D
A
N
I
S
L
R
P
Y
G
Q
E
K
F
G
T
K
A
E
L
K
N
L
N
S
F
N
Y
V
R
K
G
L
E
Y
E
E
K
R
Q
E
E
E
L
L
N
G
G
E
I
G
Q
E
T
R
R
F
D
E
S
T
G
K
T
I
L
M
R
V
K
E
G
S
D
D
Y
R
Y
F
P
E
P
D
I
V
P
L
Y
I
D
D
A
W
K
E
R
V
R
Q
T
I
P
E
L
P
D
E
R
K
A
K
Y
V
N
E
L
G
L
P
A
Y
D
A
H
V
L
T
L
T
K
E
M
S
D
F
F
E
S
T
I
E
-
H
G
A
-
D
V
K
L
T
S
N
W
L
M
G
G
V
N
E
Y
L
N
K
N
Q
V
E
L
L
D
T
K
L
T
P
E
N
L
A
G
M
I
K
L
I
E
D
G
T
M
S
S
K
I
A
K
K
V
F
P
E
L
A
A
K
G
G
N
A
----------------------------------------------------------------------------------
5
PsiBlast_PDB
69.35
51%
-83
- C2 -
4WJ3
-
GATB_PSEAE
B:
[3-282]
-----
W
E
T
V
I
G
L
E
I
H
A
Q
L
A
T
Q
S
K
I
F
S
G
S
S
T
A
-
F
G
A
A
P
N
T
Q
A
S
L
V
D
L
A
M
P
G
T
L
P
V
L
N
E
E
A
V
R
M
A
C
L
F
G
L
A
I
D
A
R
I
D
R
Q
N
V
F
A
R
K
N
Y
F
Y
P
D
L
P
K
G
Y
Q
T
S
Q
M
D
H
P
I
V
G
K
G
H
L
D
I
T
L
E
D
---
G
--
T
--
T
K
R
I
G
I
T
R
A
H
L
E
E
D
A
G
K
S
L
H
E
D------------
G
M
S
G
I
D
L
N
R
A
G
T
P
L
L
E
I
V
S
E
P
D
I
R
S
A
K
E
A
V
A
Y
V
K
A
I
H
A
L
V
R
Y
L
G
I
C
D
G
N
M
A
E
G
S
L
R
C
D
C
N
V
S
V
R
P
K
G
Q
A
E
F
G
T
R
A
E
I
K
N
V
N
S
F
R
F
I
E
K
A
I
N
H
E
I
Q
R
Q
I
E
L
I
E
D
G
G
K
V
V
Q
E
T
R
L
Y
D
P
N
K
D
E
T
R
S
M
R
G
K
E
E
A
N
D
Y
R
Y
F
P
C
P
D
L
L
P
V
V
I
E
P
E
Y
L
A
K
L
R
E
Q
L
P
E
L
P
V
Q
K
R
E
R
F
E
S
Q
Y
G
L
S
A
Y
D
A
S
V
L
S
A
S
R
E
M
A
D
Y
F
E
K
V
Q
G
I
C
-
G
-
D
A
K
L
A
A
N
W
V
M
V
E
L
G
S
L
L
N
K
D
G
L
E
I
E
Q
S
P
V
S
A
E
Q
L
G
G
M
I
L
R
I
K
D
N
T
I
S
G
K
L
A
K
M
V
F
E
A
M
A
N
G
E
G
S
A
U
N
K
U
N
K
U
N
K
U
N
K
U
N
K
U
N
K
U
N
K
U
N
K
U
N
K
U
N
K
U
N
K
U
N
K
U
N
K
U
N
K
U
N
K
U
N
K
U
N
K
U
N
K
U
N
K
U
N
K
U
N
K
U
N
K
U
N
K
U
N
K
U
N
--------