@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : Wbm0740: (2015-12-04 )
MHKILVRSNYKPLVGQIKINGSKNAILPIMAASLLSSSSVVLHNVPDLIDVHLMSELLEGLGAKVNFMHNKDHKANHTLETDCSNINNYAIQYETASKLRASFLMLGPMLSRFGKARTAFPGGCNIGKRPVDMHIKALEEMGAKIEIDGYNIIATVKGKLQGRKITLEKISVGATENIIMAATLAEGVTTINNAATEPEILDLIEFLKKIGADIKINNTKVIITGVKKLNGCIHKIISDRIEAGTYALAAIITNGKLVLEGINLSDIRCIANELEAIGAMVELYDGSIVISRKNGSIKSTNVATDPYPNFPSDMQPQLMSAMCIADGISVIEENIFENRFSHADELRKLGANISIKKNKAAINGIKSLSGANLYATDLRSTAALVLASLVASGETTINNSHHLWRGYEAMHEKLNSCGADISISP
Atome Classification :
(23 SA)
.........10........20........30.....-...40.........50........60........70........80........90........100.......110.......120.......130.......140.....-..150.....-..-160...--...--.170.......180.......190.......200.......210...-..-..-220-.-......230.......240....-...250.......260.......270.......-280.......290.......300.......310.......320.......330.......340.......350.......360.......370.......380.......390.......400.......410.......420...
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
M
H
K
I
L
VRSNYKP
L
V
G
Q
I
K
INGSKN
A
I
L
P
I
M
A
A
S
L
LS-SS
S
V
-
V
LHNVP
D
L
I
D
V
H
L
M
S
E
L
L
E
GLGA
K
V
N
F
M
HNKDHKANHTLETDCSNIN
N
Y
A
I
Q
Y
E
T
A
S
K
L
R
A
S
F
L
M
L
G
P
M
L
S
R
FGKARTAFPGGCNIGKR
P
V
D
M
H
I
K
A
L
E
EMG
A
K
I
E
I-DG
Y
N
I
I
A
T
V
K-GK-LQG
R
K
I
--
T
L
E
--
K
I
SVGATE
N
I
I
M
A
A
T
L
AE
G
V
T
TINNAAT
E
P
E
I
L
D
L
I
E
F
L
K
KIGA
D
I
K
-IN-N
T
-
K
V
I
-
I
-
T
G
V
K
K
L
N
G
C
I
H
K
I
I
S
D
R
I
EA
G
T
Y
-
A
L
A
A
I
ITN
G
K
L
V
L
EGI
N
L
S
D
I
R
C
I
A
N
E
L
E
A
I
G
A
-
M
V
E
LYD
G
S
I
V
I
SRKNGSIKSTNVATDPYPNFPSDM
Q
P
Q
L
M
S
A
M
C
I
AD
G
I
S
V
I
E
E
N
I
F
E
N
RFS
H
A
D
E
L
R
K
LGA
N
I
S
I
KKN
K
A
A
IN
G
I
K
SLSGA
N
L
Y
A
T
D
L
R
S
T
A
A
L
V
L
A
S
L
V
ASGETTINNS
H
H
L
W
R
G
Y
E
A
M
H
E
K
L
N
SCGADISISP
30
PsiBlast_CBE
96.99
41%
-104
- C6 -
5BQ2
2
?
B:
[9-428]
M
D
K
L
I
I
T
G
G
N
R
-
L
D
G
E
I
R
I
S
G
A
K
N
S
A
L
P
I
L
A
A
T
L
L
A
-
D
T
P
V
-
T
V
C
N
L
P
H
L
H
D
I
T
T
M
I
E
L
F
G
R
M
G
V
Q
P
I
I
----
D
E
K
L
N
--
V
E
V
D
A
S
S
I
K
T
L
V
A
P
Y
E
L
V
K
T
M
R
A
S
I
L
V
L
G
P
M
L
A
R
F
G
E
A
E
V
A
L
P
G
G
A
-
I
G
S
R
P
V
D
L
H
I
R
G
L
E
A
M
G
A
Q
I
E
V
-
E
G
G
Y
I
K
A
K
A
P
A
G
G
-
L
R
G
G
H
F
--
F
F
D
--
T
V
S
V
T
G
T
E
N
L
M
M
A
A
A
L
A
N
G
R
T
V
L
Q
N
A
A
R
E
P
E
V
V
D
L
A
N
C
L
N
A
M
G
A
N
V
Q
G
A
G
-
S
D
-
T
I
V
-
I
-
E
G
V
K
R
L
G
G
A
R
Y
D
V
L
P
D
R
I
E
T
G
T
Y
-
L
V
A
A
A
A
T
G
G
R
V
K
L
K
D
T
D
P
T
I
L
E
A
V
L
Q
K
L
E
E
A
G
A
-
H
I
S
T
G
S
N
W
I
E
L
D
M
K
G
N
R
P
K
A
V
N
V
R
T
A
P
Y
P
A
F
P
T
D
M
Q
A
Q
F
I
S
M
N
A
V
A
E
G
T
G
A
V
I
E
T
V
F
E
N
R
F
M
H
V
Y
E
M
N
R
M
G
A
Q
I
L
V
E
G
N
T
A
I
V
T
G
V
P
K
L
K
G
A
P
V
M
A
T
D
L
R
A
S
A
S
L
V
I
A
G
L
V
A
E
G
D
T
L
I
D
R
I
Y
H
I
D
R
G
Y
E
C
I
E
E
K
L
Q
L
L
G
A
K
I
R
R
V
P
29
PsiBlast_CBE
96.69
41%
-102
- C6 -
5BQ2
3
?
C:
[9-428]
M
D
K
L
I
I
T
G
G
N
R
-
L
D
G
E
I
R
I
S
G
A
K
N
S
A
L
P
I
L
A
A
T
L
L
A
-
D
T
P
V
-
T
V
C
N
L
P
H
L
H
D
I
T
T
M
I
E
L
F
G
R
M
G
V
Q
P
I
I
----
D
E
K
L
N
--
V
E
V
D
A
S
S
I
K
T
L
V
A
P
Y
E
L
V
K
T
M
R
A
S
I
L
V
L
G
P
M
L
A
R
F
G
E
A
E
V
A
L
P
G
G
A
-
I
G
S
R
P
V
D
L
H
I
R
G
L
E
A
M
G
A
Q
I
E
V
-
E
G
G
Y
I
K
A
K
A
P
A
G
G
-
L
R
G
G
H
F
--
F
F
D
--
T
V
S
V
T
G
T
E
N
L
M
M
A
A
A
L
A
N
G
R
T
V
L
Q
N
A
A
R
E
P
E
V
V
D
L
A
N
C
L
N
A
M
G
A
N
V
Q
G
A
G
-
S
D
-
T
I
V
-
I
-
E
G
V
K
R
L
G
G
A
R
Y
D
V
L
P
D
R
I
E
T
G
T
Y
-
L
V
A
A
A
A
T
G
G
R
V
K
L
K
D
T
D
P
T
I
L
E
A
V
L
Q
K
L
E
E
A
G
A
-
H
I
S
T
G
S
N
W
I
E
L
D
M
K
G
N
R
P
K
A
V
N
V
R
T
A
P
Y
P
A
F
P
T
D
M
Q
A
Q
F
I
S
M
N
A
V
A
E
G
T
G
A
V
I
E
T
V
F
E
N
R
F
M
H
V
Y
E
M
N
R
M
G
A
Q
I
L
V
E
G
N
T
A
I
V
T
G
V
P
K
L
K
G
A
P
V
M
A
T
D
L
R
A
S
A
S
L
V
I
A
G
L
V
A
E
G
D
T
L
I
D
R
I
Y
H
I
D
R
G
Y
E
C
I
E
E
K
L
Q
L
L
G
A
K
I
R
R
V
P
9
PsiBlast_PDB
96.50
41%
-103
- C6 -
5BQ2
2
?
A:
[9-428]
M
D
K
L
I
I
T
G
G
N
R
-
L
D
G
E
I
R
I
S
G
A
K
N
S
A
L
P
I
L
A
A
T
L
L
A
-
D
T
P
V
-
T
V
C
N
L
P
H
L
H
D
I
T
T
M
I
E
L
F
G
R
M
G
V
Q
P
I
I
----
D
E
K
L
N
--
V
E
V
D
A
S
S
I
K
T
L
V
A
P
Y
E
L
V
K
T
M
R
A
S
I
L
V
L
G
P
M
L
A
R
F
G
E
A
E
V
A
L
P
G
G
-
A
I
G
S
R
P
V
D
L
H
I
R
G
L
E
A
M
G
A
Q
I
E
V
-
E
G
G
Y
I
K
A
K
A
P
A
G
G
-
L
R
G
G
H
F
--
F
F
D
--
T
V
S
V
T
G
T
E
N
L
M
M
A
A
A
L
A
N
G
R
T
V
L
Q
N
A
A
R
E
P
E
V
V
D
L
A
N
C
L
N
A
M
G
A
N
V
Q
G
A
G
-
S
D
-
T
I
V
-
I
-
E
G
V
K
R
L
G
G
A
R
Y
D
V
L
P
D
R
I
E
T
G
T
Y
-
L
V
A
A
A
A
T
G
G
R
V
K
L
K
D
T
D
P
T
I
L
E
A
V
L
Q
K
L
E
E
A
G
A
-
H
I
S
T
G
S
N
W
I
E
L
D
M
K
G
N
R
P
K
A
V
N
V
R
T
A
P
Y
P
A
F
P
T
D
M
Q
A
Q
F
I
S
M
N
A
V
A
E
G
T
G
A
V
I
E
T
V
F
E
N
R
F
M
H
V
Y
E
M
N
R
M
G
A
Q
I
L
V
E
G
N
T
A
I
V
T
G
V
P
K
L
K
G
A
P
V
M
A
T
D
L
R
A
S
A
S
L
V
I
A
G
L
V
A
E
G
D
T
L
I
D
R
I
Y
H
I
D
R
G
Y
E
C
I
E
E
K
L
Q
L
L
G
A
K
I
R
R
V
P
28
PsiBlast_CBE
96.40
41%
-104
- C6 -
5BQ2
3
?
D:
[9-428]
M
D
K
L
I
I
T
G
G
N
R
-
L
D
G
E
I
R
I
S
G
A
K
N
S
A
L
P
I
L
A
A
T
L
L
A
-
D
T
P
V
-
T
V
C
N
L
P
H
L
H
D
I
T
T
M
I
E
L
F
G
R
M
G
V
Q
P
I
I
----
D
E
K
L
N
--
V
E
V
D
A
S
S
I
K
T
L
V
A
P
Y
E
L
V
K
T
M
R
A
S
I
L
V
L
G
P
M
L
A
R
F
G
E
A
E
V
A
L
P
G
G
A
-
I
G
S
R
P
V
D
L
H
I
R
G
L
E
A
M
G
A
Q
I
E
V
-
E
G
G
Y
I
K
A
K
A
P
A
G
G
-
L
R
G
G
H
F
--
F
F
D
--
T
V
S
V
T
G
T
E
N
L
M
M
A
A
A
L
A
N
G
R
T
V
L
Q
N
A
A
R
E
P
E
V
V
D
L
A
N
C
L
N
A
M
G
A
N
V
Q
G
A
G
-
S
D
-
T
I
V
-
I
-
E
G
V
K
R
L
G
G
A
R
Y
D
V
L
P
D
R
I
E
T
G
T
Y
-
L
V
A
A
A
A
T
G
G
R
V
K
L
K
D
T
D
P
T
I
L
E
A
V
L
Q
K
L
E
E
A
G
A
-
H
I
S
T
G
S
N
W
I
E
L
D
M
K
G
N
R
P
K
A
V
N
V
R
T
A
P
Y
P
A
F
P
T
D
M
Q
A
Q
F
I
S
M
N
A
V
A
E
G
T
G
A
V
I
E
T
V
F
E
N
R
F
M
H
V
Y
E
M
N
R
M
G
A
Q
I
L
V
E
G
N
T
A
I
V
T
G
V
P
K
L
K
G
A
P
V
M
A
T
D
L
R
A
S
A
S
L
V
I
A
G
L
V
A
E
G
D
T
L
I
D
R
I
Y
H
I
D
R
G
Y
E
C
I
E
E
K
L
Q
L
L
G
A
K
I
R
R
V
P
40
HHSearch
93.64
44%
-103
- C6 -
3R38
10
MURA1_LISMO
A:
[25-440]
M
E
K
I
I
V
R
G
G
K
-
Q
L
N
G
S
V
K
M
E
G
A
K
N
A
V
L
P
V
I
A
A
T
L
L
A
S
K
G
T
S
-
V
L
K
N
V
P
N
L
S
D
V
F
T
I
N
E
V
L
K
Y
L
N
A
D
V
S
F
V
N
D
-------
E
V
T
V
D
A
T
G
E
I
T
S
D
A
P
F
E
Y
V
R
K
M
R
A
S
I
V
V
M
G
P
L
L
A
R
T
G
S
A
R
V
A
L
P
G
G
C
A
I
G
S
R
P
V
D
L
H
L
K
G
F
E
A
M
G
A
V
V
K
I
-
E
N
G
Y
I
E
A
T
A
E
--
K
-
L
V
G
A
K
V
--
Y
L
D
--
F
P
S
V
G
A
T
Q
N
I
M
M
A
A
T
L
A
E
G
T
T
V
I
E
N
V
A
R
E
P
E
I
V
D
L
A
N
F
L
N
Q
M
G
A
R
V
I
-
G
A
G
T
E
-
V
I
R
-
I
-
E
G
V
K
E
L
T
A
T
E
H
S
I
I
P
D
R
I
E
A
G
T
F
-
M
I
A
A
A
I
T
G
G
N
V
L
I
E
D
A
V
P
E
H
I
S
S
L
I
A
K
L
E
E
M
G
V
-
Q
I
I
E
E
--
G
I
R
V
I
G
P
-
D
K
L
K
A
V
D
V
K
T
M
P
H
P
G
F
P
T
D
M
Q
S
Q
M
M
V
I
Q
M
L
S
E
G
T
S
I
M
T
E
T
V
F
E
N
R
F
M
H
V
E
E
M
R
R
M
N
A
D
M
K
I
E
G
H
S
V
I
I
S
G
P
A
K
L
Q
G
A
E
V
A
A
T
D
L
R
A
A
A
A
L
I
L
A
G
L
V
A
D
G
Y
T
Q
V
T
E
L
K
Y
L
D
R
G
Y
N
N
F
H
G
K
L
Q
A
L
G
A
D
V
E
R
V
D
47
HHSearch
93.27
41%
-106
- C6 -
2YVW
2
MURA_AQUAE
A:
[10-422]
R
D
Y
F
V
I
R
G
G
K
-
P
L
T
G
K
V
K
I
S
G
A
K
N
A
A
L
P
I
M
F
A
T
I
L
T
-
E
E
P
C
-
T
I
T
N
V
P
D
L
L
D
V
R
N
T
L
L
L
L
R
E
L
G
A
E
L
E
F
L
N
N
-------
T
V
F
I
N
P
S
-
I
N
S
F
I
T
N
Q
E
I
I
R
R
M
R
A
S
V
L
S
L
G
P
L
L
G
R
F
G
R
A
V
V
G
L
P
G
G
C
S
I
G
A
R
P
I
D
Q
H
L
K
F
F
K
E
A
G
A
D
V
E
V
-
R
E
G
Y
V
Y
V
N
L
K
-
E
--
K
R
R
V
H
F
--
K
F
D
LV
T
V
T
G
T
E
N
-
A
L
L
Y
L
A
S
V
-
P
E
E
S
I
L
E
N
I
A
L
E
P
E
V
M
D
L
I
E
V
L
K
K
M
G
A
H
V
K
-
V
E
-
G
R
-
S
A
Y
-
V
-
K
G
S
E
N
L
K
G
F
T
H
S
V
I
P
D
R
I
E
A
G
T
F
-
M
V
G
A
V
L
T
D
G
E
I
L
L
E
N
A
R
I
N
H
L
R
A
V
V
E
K
L
K
L
I
G
G
-
E
V
V
E
E
N
G
N
L
R
V
F
R
K
-
E
S
L
R
A
C
D
I
E
T
Q
V
Y
P
G
F
P
T
D
M
Q
A
Q
F
M
A
L
L
S
V
A
K
G
K
S
R
I
K
E
N
I
F
E
H
R
F
H
H
A
Q
E
L
N
R
L
G
A
N
I
T
V
R
G
N
T
A
Y
V
E
G
V
E
R
L
Y
G
S
E
V
Y
S
T
D
L
R
A
S
A
S
L
V
L
A
G
L
V
A
Q
G
E
T
V
V
R
D
V
Y
H
L
D
R
G
Y
E
K
L
E
E
K
L
K
K
L
G
A
D
I
E
R
V
S
23
PsiBlast_CBE
93.03
43%
-102
- C6 -
4R7U
3
MURA_VIBCH
B:
[4-417]
M
E
K
F
R
V
I
G
S
T
Q
P
L
Q
G
E
V
T
I
S
G
A
K
N
A
A
L
P
I
L
F
A
S
I
L
A
-
E
E
P
V
-
E
V
A
N
V
P
H
L
R
D
I
D
T
T
M
E
L
L
E
R
L
G
A
K
V
--------
E
R
N
G
S
V
H
V
D
A
G
P
I
N
Q
Y
C
A
P
Y
D
L
V
K
T
M
R
A
S
I
W
A
L
G
P
L
V
A
R
F
G
Q
G
Q
V
S
L
P
G
G
C
A
I
G
A
R
P
V
D
L
H
I
H
G
L
E
Q
L
G
A
T
I
T
L
E
D
G
Y
-
V
K
A
H
V
D
-
G
R
-
L
Q
G
A
H
I
--
V
M
D
--
K
V
S
V
G
A
T
I
T
I
M
C
A
A
T
L
A
E
G
T
T
V
L
D
N
A
A
R
E
P
E
I
V
D
T
A
M
F
L
N
K
L
G
A
K
I
S
-
G
A
-
G
T
-
D
S
I
T
I
-
E
G
V
E
R
L
G
G
G
K
H
A
V
V
P
D
R
I
E
T
G
T
F
-
L
V
A
A
A
V
S
R
G
K
I
V
C
R
N
T
H
A
H
L
L
E
A
V
L
A
K
L
E
E
A
G
A
-
E
I
E
C
G
E
D
W
I
S
L
D
M
T
G
R
E
L
K
A
V
T
V
R
T
A
P
H
P
G
F
P
T
D
M
Q
A
Q
F
T
L
L
N
M
M
A
K
G
G
G
V
I
T
E
T
I
F
E
N
R
F
M
H
V
P
E
L
K
R
M
G
A
K
A
E
I
E
G
N
T
V
I
C
G
D
V
D
R
L
S
G
A
Q
V
M
A
T
D
L
R
A
S
A
S
L
V
I
A
G
C
I
A
K
G
E
T
I
V
D
R
I
Y
H
I
D
R
G
Y
E
R
I
E
D
K
L
S
A
L
G
A
N
I
E
R
F
R
7
PsiBlast_PDB
93.01
41%
-106
- C6 -
3SPB
-
MURA_ENTCC
A:
[1-413]
M
D
K
F
R
V
Q
G
P
T
R
-
L
Q
G
E
V
T
I
S
G
A
K
N
A
A
L
P
I
L
F
A
A
L
L
A
-
E
E
P
V
-
E
I
Q
N
V
P
K
L
K
D
I
D
T
T
M
K
L
L
T
Q
L
G
T
K
V
--------
E
R
-
G
S
V
W
I
D
A
S
N
V
N
N
F
S
A
P
Y
D
L
V
K
T
M
R
A
S
I
W
A
L
G
P
L
V
A
R
F
G
Q
G
Q
V
S
L
P
G
G
C
A
I
G
A
R
P
V
D
L
H
I
F
G
L
E
K
L
G
A
E
I
K
L
-
E
E
G
Y
V
K
A
S
V
N
-
G
R
-
L
K
G
A
H
I
--
V
M
D
--
K
V
S
V
G
A
T
V
T
I
M
S
A
A
T
L
A
E
G
T
T
I
I
E
N
A
A
R
E
P
E
I
V
D
T
A
N
F
L
V
A
L
G
A
K
I
S
-
G
Q
-
G
T
D
R
I
T
-
I
-
E
G
V
E
R
L
G
G
G
V
Y
R
V
L
P
D
R
I
E
T
G
T
F
-
L
V
A
A
A
I
S
G
G
K
I
V
C
R
N
A
Q
P
D
T
L
D
A
V
L
A
K
L
R
E
A
G
A
-
D
I
E
T
G
E
D
W
I
S
L
D
M
H
G
K
R
P
K
A
V
T
V
R
T
A
P
H
P
A
F
P
T
D
M
Q
A
Q
F
T
L
L
N
L
V
A
E
G
T
G
V
I
T
E
T
I
F
E
N
R
F
M
H
V
P
E
L
I
R
M
G
A
H
A
E
I
E
S
N
T
V
I
C
H
G
V
E
K
L
S
G
A
Q
V
M
A
T
D
L
R
A
S
A
S
L
V
L
A
G
C
I
A
E
G
T
T
V
V
D
R
I
Y
H
I
D
R
G
Y
E
R
I
E
D
K
L
R
A
L
G
A
N
I
E
R
V
K
8
PsiBlast_PDB
92.96
42%
-102
- C6 -
2YVW
2
MURA_AQUAE
A:
[19-420]
----------
K
P
L
T
G
K
V
K
I
S
G
A
K
N
A
A
L
P
I
M
F
A
T
I
L
T
-
E
E
P
C
-
T
I
T
N
V
P
D
L
L
D
V
R
N
T
L
L
L
L
R
E
L
G
A
E
L
E
F
L
N
N
-------
T
V
F
I
N
P
S
-
I
N
S
F
I
T
N
Q
E
I
I
R
R
M
R
A
S
V
L
S
L
G
P
L
L
G
R
F
G
R
A
V
V
G
L
P
G
G
C
S
I
G
A
R
P
I
D
Q
H
L
K
F
F
K
E
A
G
A
D
V
E
V
R
E
G
Y
-
V
Y
V
N
L
K
-
E
K
----
R
R
V
H
F
K
F
D
--
L
V
T
V
T
G
T
E
N
A
L
L
Y
L
A
S
V
P
E
E
S
I
L
E
N
I
A
L
E
P
E
V
M
D
L
I
E
V
L
K
K
M
G
A
H
V
K
-
V
E
-
G
R
-
S
A
Y
-
V
-
K
G
S
E
N
L
K
G
F
T
H
S
V
I
P
D
R
I
E
A
G
T
F
-
M
V
G
A
V
L
T
D
G
E
I
L
L
E
N
A
R
I
N
H
L
R
A
V
V
E
K
L
K
L
I
G
G
-
E
V
V
E
E
N
G
N
L
R
V
F
R
K
E
-
S
L
R
A
C
D
I
E
T
Q
V
Y
P
G
F
P
T
D
M
Q
A
Q
F
M
A
L
L
S
V
A
K
G
K
S
R
I
K
E
N
I
F
E
H
R
F
H
H
A
Q
E
L
N
R
L
G
A
N
I
T
V
R
G
N
T
A
Y
V
E
G
V
E
R
L
Y
G
S
E
V
Y
S
T
D
L
R
A
S
A
S
L
V
L
A
G
L
V
A
Q
G
E
T
V
V
R
D
V
Y
H
L
D
R
G
Y
E
K
L
E
E
K
L
K
K
L
G
A
D
I
E
R
V
S
2
PsiBlast_PDB
92.59
42%
-103
- C6 -
3VCY
4
MURA_VIBFM
A:
[1-414]
M
D
K
F
R
I
Q
G
S
D
K
P
L
S
G
E
V
T
I
S
G
A
K
N
A
A
L
P
I
L
F
A
S
L
L
A
-
E
E
P
V
-
E
V
A
N
V
P
K
L
R
D
V
D
T
T
M
E
L
L
K
R
L
G
A
E
V
S
--------
R
N
G
S
V
H
I
D
A
S
G
V
N
D
F
C
A
P
Y
D
L
V
K
T
M
R
A
S
I
W
A
L
G
P
L
V
A
R
F
G
K
G
Q
V
S
L
P
G
G
C
A
I
G
A
R
P
V
D
L
H
I
H
G
L
E
Q
L
G
A
T
I
K
L
-
E
E
G
Y
V
K
A
E
V
D
-
G
R
-
L
K
G
A
H
I
--
V
M
D
--
K
V
S
V
G
A
T
I
T
V
M
C
A
A
T
L
A
E
G
T
T
V
L
E
N
A
A
R
E
P
E
I
V
D
T
A
N
F
L
N
A
I
G
A
K
V
S
-
G
M
-
G
T
-
D
T
I
T
I
-
E
G
V
E
R
L
G
G
G
Y
H
E
V
V
A
D
R
I
E
T
G
T
F
-
L
V
A
A
A
V
S
G
G
K
I
V
C
K
N
T
K
A
H
L
L
E
A
V
L
A
K
L
E
E
A
G
A
-
D
V
Q
T
G
D
D
W
I
S
L
D
M
T
G
R
E
L
K
A
V
N
I
R
T
A
P
H
P
A
F
P
T
D
M
Q
A
Q
F
T
L
L
N
M
M
A
K
G
S
G
I
I
T
E
T
I
F
E
N
R
F
M
H
I
P
E
L
Q
R
M
G
A
H
A
E
I
E
G
N
T
A
I
C
G
D
T
D
G
L
S
G
A
Q
V
M
A
T
D
L
R
A
S
A
S
L
V
I
A
G
C
I
A
K
G
E
T
I
V
D
R
I
Y
H
I
D
R
G
Y
D
K
I
E
D
K
L
T
A
L
G
A
N
I
E
R
V
H
27
PsiBlast_CBE
92.48
41%
-105
- C6 -
1NAW
2
MURA_ENTCC
B:
[1-413]
M
D
K
F
R
V
Q
G
P
T
R
-
L
Q
G
E
V
T
I
S
G
A
K
N
A
A
L
P
I
L
F
A
A
L
L
A
-
E
E
P
V
-
E
I
Q
N
V
P
K
L
K
D
I
D
T
T
M
K
L
L
T
Q
L
G
T
K
V
--------
E
R
N
G
S
V
W
I
D
A
S
N
V
N
N
F
S
A
P
Y
D
L
V
K
T
M
R
A
S
I
W
A
L
G
P
L
V
A
R
F
G
Q
G
Q
V
S
L
P
G
G
C
A
I
G
A
R
P
V
D
L
H
I
F
G
L
E
K
L
G
A
E
I
K
L
-
E
E
G
Y
V
K
A
S
V
N
-
G
R
-
L
K
G
A
H
I
--
V
M
D
--
K
V
S
V
G
A
T
V
T
I
M
S
A
A
T
L
A
E
G
T
T
I
I
E
N
A
A
R
E
P
E
I
V
D
T
A
N
F
L
V
A
L
G
A
K
I
S
-
G
Q
-
G
T
D
R
I
T
-
I
-
E
G
V
E
R
L
G
G
G
V
Y
R
V
L
P
D
R
I
E
T
G
T
F
-
L
V
A
A
A
I
S
G
G
K
I
V
C
R
N
A
Q
P
D
T
L
D
A
V
L
A
K
L
R
E
A
G
A
-
D
I
E
T
G
E
D
W
I
S
L
D
M
H
G
K
R
P
K
A
V
T
V
R
T
A
P
H
P
A
F
P
T
D
M
Q
A
Q
F
T
L
L
N
L
V
A
E
G
T
G
V
I
T
E
T
I
F
E
N
R
F
M
H
V
P
E
L
I
R
M
G
A
H
A
E
I
E
S
N
T
V
I
C
H
G
V
E
K
L
S
G
A
Q
V
M
A
T
D
L
R
A
S
A
S
L
V
L
A
G
C
I
A
E
G
T
T
V
V
D
R
I
Y
H
I
D
R
G
Y
E
R
I
E
D
K
L
R
A
L
G
A
N
I
E
R
V
K
21
PsiBlast_CBE
92.42
43%
-103
- C6 -
4R7U
4
MURA_VIBCH
D:
[4-417]
M
E
K
F
R
V
I
G
S
T
Q
P
L
Q
G
E
V
T
I
S
G
A
K
N
A
A
L
P
I
L
F
A
S
I
L
A
-
E
E
P
V
-
E
V
A
N
V
P
H
L
R
D
I
D
T
T
M
E
L
L
E
R
L
G
A
K
V
--------
E
R
N
G
S
V
H
V
D
A
G
P
I
N
Q
Y
C
A
P
Y
D
L
V
K
T
M
R
A
S
I
W
A
L
G
P
L
V
A
R
F
G
Q
G
Q
V
S
L
P
G
G
C
A
I
G
A
R
P
V
D
L
H
I
H
G
L
E
Q
L
G
A
T
I
T
L
E
D
G
Y
-
V
K
A
H
V
D
-
G
R
-
L
Q
G
A
H
I
--
V
M
D
--
K
V
S
V
G
A
T
I
T
I
M
C
A
A
T
L
A
E
G
T
T
V
L
D
N
A
A
R
E
P
E
I
V
D
T
A
M
F
L
N
K
L
G
A
K
I
S
-
G
A
-
G
T
-
D
S
I
T
I
-
E
G
V
E
R
L
G
G
G
K
H
A
V
V
P
D
R
I
E
T
G
T
F
-
L
V
A
A
A
V
S
R
G
K
I
V
C
R
N
T
H
A
H
L
L
E
A
V
L
A
K
L
E
E
A
G
A
-
E
I
E
C
G
E
D
W
I
S
L
D
M
T
G
R
E
L
K
A
V
T
V
R
T
A
P
H
P
G
F
P
T
D
M
Q
A
Q
F
T
L
L
N
M
M
A
K
G
G
G
V
I
T
E
T
I
F
E
N
R
F
M
H
V
P
E
L
K
R
M
G
A
K
A
E
I
E
G
N
T
V
I
C
G
D
V
D
R
L
S
G
A
Q
V
M
A
T
D
L
R
A
S
A
S
L
V
I
A
G
C
I
A
K
G
E
T
I
V
D
R
I
Y
H
I
D
R
G
Y
E
R
I
E
D
K
L
S
A
L
G
A
N
I
E
R
F
R
6
PsiBlast_PDB
92.37
41%
-99
- C6 -
2RL2
5
MURA_HAEIN
A:
[1-415]
M
D
K
F
R
V
Y
G
Q
S
R
-
L
S
G
S
V
N
I
S
G
A
K
N
A
A
L
P
I
L
F
A
A
I
L
A
-
T
E
P
V
-
K
L
T
N
V
P
E
L
K
D
I
E
T
T
L
K
I
L
R
Q
L
G
V
V
V
------
D
R
D
A
T
G
A
V
L
L
D
A
S
N
I
N
H
F
T
A
P
Y
E
L
V
K
T
M
R
A
S
I
W
A
L
A
P
L
V
A
R
F
H
Q
G
Q
V
S
L
P
G
G
C
S
I
G
A
R
P
V
D
L
H
I
S
G
L
E
K
L
G
A
D
I
V
L
-
E
E
G
Y
V
K
A
Q
V
S
-
D
R
-
L
V
G
T
R
I
--
V
I
E
--
K
V
S
V
G
A
T
L
S
I
M
M
A
A
T
L
A
K
G
T
T
V
I
E
N
A
A
R
E
P
E
I
V
D
T
A
D
F
L
N
K
M
G
A
K
I
T
G
A
G
-
S
A
-
H
I
T
-
I
-
E
G
V
E
R
L
T
G
C
E
H
S
V
V
P
D
R
I
E
T
G
T
F
-
L
I
A
A
A
I
S
G
G
C
V
V
C
Q
N
T
K
A
D
T
L
D
A
V
I
D
K
L
R
E
A
G
A
-
Q
V
D
V
T
E
N
S
I
T
L
D
M
L
G
N
R
P
K
A
V
N
I
R
T
A
P
H
P
G
F
P
T
D
M
Q
A
Q
F
T
L
L
N
M
V
A
E
G
T
S
I
I
T
E
T
I
F
E
N
R
F
M
H
I
P
E
L
I
R
M
G
G
K
A
E
I
E
G
N
T
A
V
C
H
G
V
E
Q
L
S
G
T
E
V
I
A
T
D
L
R
A
S
I
S
L
V
L
A
G
C
I
A
T
G
E
T
I
V
D
R
I
Y
H
I
D
R
G
Y
E
H
I
E
D
K
L
R
G
L
G
A
K
I
E
R
F
S
1
PsiBlast_PDB
92.13
43%
-101
- C6 -
4R7U
4
MURA_VIBCH
A:
[4-417]
M
E
K
F
R
V
I
G
S
T
Q
P
L
Q
G
E
V
T
I
S
G
A
K
N
A
A
L
P
I
L
F
A
S
I
L
A
-
E
E
P
V
-
E
V
A
N
V
P
H
L
R
D
I
D
T
T
M
E
L
L
E
R
L
G
A
K
V
--------
E
R
N
G
S
V
H
V
D
A
G
P
I
N
Q
Y
C
A
P
Y
D
L
V
K
T
M
R
A
S
I
W
A
L
G
P
L
V
A
R
F
G
Q
G
Q
V
S
L
P
G
G
C
A
I
G
A
R
P
V
D
L
H
I
H
G
L
E
Q
L
G
A
T
I
T
L
E
D
G
Y
-
V
K
A
H
V
D
-
G
R
-
L
Q
G
A
H
I
--
V
M
D
--
K
V
S
V
G
A
T
I
T
I
M
C
A
A
T
L
A
E
G
T
T
V
L
D
N
A
A
R
E
P
E
I
V
D
T
A
M
F
L
N
K
L
G
A
K
I
S
-
G
A
-
G
T
-
D
S
I
T
I
-
E
G
V
E
R
L
G
G
G
K
H
A
V
V
P
D
R
I
E
T
G
T
F
-
L
V
A
A
A
V
S
R
G
K
I
V
C
R
N
T
H
A
H
L
L
E
A
V
L
A
K
L
E
E
A
G
A
-
E
I
E
C
G
E
D
W
I
S
L
D
M
T
G
R
E
L
K
A
V
T
V
R
T
A
P
H
P
G
F
P
T
D
M
Q
A
Q
F
T
L
L
N
M
M
A
K
G
G
G
V
I
T
E
T
I
F
E
N
R
F
M
H
V
P
E
L
K
R
M
G
A
K
A
E
I
E
G
N
T
V
I
C
G
D
V
D
R
L
S
G
A
Q
V
M
A
T
D
L
R
A
S
A
S
L
V
I
A
G
C
I
A
K
G
E
T
I
V
D
R
I
Y
H
I
D
R
G
Y
E
R
I
E
D
K
L
S
A
L
G
A
N
I
E
R
F
R
5
PsiBlast_PDB
92.03
41%
-100
- C6 -
2RL1
2
MURA_HAEIN
A:
[1-415]
M
D
K
F
R
V
Y
G
Q
S
R
-
L
S
G
S
V
N
I
S
G
A
K
N
A
A
L
P
I
L
F
A
A
I
L
A
-
T
E
P
V
-
K
L
T
N
V
P
E
L
K
D
I
E
T
T
L
K
I
L
R
Q
L
G
V
V
V
------
D
R
D
A
T
G
A
V
L
L
D
A
S
N
I
N
H
F
T
A
P
Y
E
L
V
K
T
M
R
A
S
I
W
A
L
A
P
L
V
A
R
F
H
Q
G
Q
V
S
L
P
G
G
C
S
I
G
A
R
P
V
D
L
H
I
S
G
L
E
K
L
G
A
D
I
V
L
-
E
E
G
Y
V
K
A
Q
V
S
-
D
R
-
L
V
G
T
R
I
--
V
I
E
--
K
V
S
V
G
A
T
L
S
I
M
M
A
A
T
L
A
K
G
T
T
V
I
E
N
A
A
R
E
P
E
I
V
D
T
A
D
F
L
N
K
M
G
A
K
I
T
G
A
G
-
S
A
-
H
I
T
-
I
-
E
G
V
E
R
L
T
G
C
E
H
S
V
V
P
D
R
I
E
T
G
T
F
-
L
I
A
A
A
I
S
G
G
C
V
V
C
Q
N
T
K
A
D
T
L
D
A
V
I
D
K
L
R
E
A
G
A
-
Q
V
D
V
T
E
N
S
I
T
L
D
M
L
G
N
R
P
K
A
V
N
I
R
T
A
P
H
P
G
F
P
T
D
M
Q
A
Q
F
T
L
L
N
M
V
A
E
G
T
S
I
I
T
E
T
I
F
E
N
R
F
M
H
I
P
E
L
I
R
M
G
G
K
A
E
I
E
G
N
T
A
V
C
H
G
V
E
Q
L
S
G
T
E
V
I
A
T
D
L
R
A
S
I
S
L
V
L
A
G
C
I
A
T
G
E
T
I
V
D
R
I
Y
H
I
D
R
G
Y
E
H
I
E
D
K
L
R
G
L
G
A
K
I
E
R
F
S
11
PsiBlast_PDB
91.97
45%
-93
- C6 -
3SG1
-
MURA1_BACAN
A:
[25-438]
M
E
K
I
I
V
R
G
G
-
K
R
L
N
G
T
V
R
V
E
G
A
K
N
A
V
L
P
I
I
A
A
A
L
L
A
-
S
D
G
K
N
V
L
S
E
V
P
V
L
S
D
V
Y
T
I
N
E
V
L
R
H
L
N
A
E
V
V
F
E
N
N
Q
-------
V
T
I
D
A
S
K
E
L
N
I
E
A
P
F
E
Y
V
R
K
M
R
A
S
V
Q
V
M
G
P
L
L
A
R
N
G
R
A
R
I
A
L
P
G
G
C
A
I
G
S
R
P
I
D
Q
H
L
K
G
F
E
A
M
G
A
K
V
Q
V
-
G
N
G
F
V
E
A
Y
V
E
-
G
E
-
L
K
G
A
K
I
--
Y
L
D
--
F
P
S
V
G
A
T
E
N
I
M
S
A
A
T
L
A
K
G
T
T
I
L
E
N
A
A
K
E
P
E
I
V
D
L
A
N
F
L
N
A
M
G
A
K
V
R
-
G
A
-
G
T
-
G
T
I
R
I
-
E
G
V
D
K
L
Y
G
A
N
H
S
I
I
P
D
R
I
E
A
G
T
F
-
M
V
A
A
A
I
T
G
G
D
I
L
I
E
N
A
V
P
E
H
L
R
S
I
T
A
K
M
E
E
M
G
V
K
I
I
E
E
N
E
G
V
R
V
I
G
P
D
--
K
L
K
A
V
D
I
K
T
M
P
H
P
G
F
P
T
D
M
Q
S
Q
M
M
A
L
L
L
Q
A
D
G
T
S
M
I
T
E
T
V
F
E
N
R
F
M
H
V
E
E
F
R
R
M
N
A
D
I
K
I
E
G
R
S
V
I
M
N
G
P
N
S
L
Q
G
A
E
V
G
A
T
D
L
R
A
A
A
A
L
I
L
A
G
L
V
S
E
G
Y
T
R
V
T
E
L
K
H
L
D
R
G
Y
V
D
F
H
K
K
L
A
A
L
G
A
T
I
E
R
V
N
3
PsiBlast_PDB
91.60
41%
-99
- C6 -
1UAE
2
MURA_ECOLI
A:
[1-413]
M
D
K
F
R
V
Q
G
P
T
K
-
L
Q
G
E
V
T
I
S
G
A
K
N
A
A
L
P
I
L
F
A
A
L
L
A
-
E
E
P
V
-
E
I
Q
N
V
P
K
L
K
D
V
D
T
S
M
K
L
L
S
Q
L
G
A
K
V
--------
E
R
N
G
S
V
H
I
D
A
R
D
V
N
V
F
C
A
P
Y
D
L
V
K
T
M
R
A
S
I
W
A
L
G
P
L
V
A
R
F
G
Q
G
Q
V
S
L
P
G
G
C
T
I
G
A
R
P
V
D
L
H
I
S
G
L
E
Q
L
G
A
T
I
K
L
-
E
E
G
Y
V
K
A
S
V
D
-
G
R
-
L
K
G
A
H
I
--
V
M
D
--
K
V
S
V
G
A
T
V
T
I
M
C
A
A
T
L
A
E
G
T
T
I
I
E
N
A
A
R
E
P
E
I
V
D
T
A
N
F
L
I
T
L
G
A
K
I
S
-
G
Q
-
G
T
D
R
I
V
-
I
-
E
G
V
E
R
L
G
G
G
V
Y
R
V
L
P
D
R
I
E
T
G
T
F
-
L
V
A
A
A
I
S
R
G
K
I
I
C
R
N
A
Q
P
D
T
L
D
A
V
L
A
K
L
R
D
A
G
A
-
D
I
E
V
G
E
D
W
I
S
L
D
M
H
G
K
R
P
K
A
V
N
V
R
T
A
P
H
P
A
F
P
T
D
M
Q
A
Q
F
T
L
L
N
L
V
A
E
G
T
G
F
I
T
E
T
V
F
E
N
R
F
M
H
V
P
E
L
S
R
M
G
A
H
A
E
I
E
S
N
T
V
I
C
H
G
V
E
K
L
S
G
A
Q
V
M
A
T
D
L
R
A
S
A
S
L
V
L
A
G
C
I
A
E
G
T
T
V
V
D
R
I
Y
H
I
D
R
G
Y
E
R
I
E
D
K
L
R
A
L
G
A
N
I
E
R
V
K
22
PsiBlast_CBE
91.40
43%
-101
- C6 -
4R7U
4
MURA_VIBCH
C:
[4-417]
M
E
K
F
R
V
I
G
S
T
Q
P
L
Q
G
E
V
T
I
S
G
A
K
N
A
A
L
P
I
L
F
A
S
I
L
A
-
E
E
P
V
-
E
V
A
N
V
P
H
L
R
D
I
D
T
T
M
E
L
L
E
R
L
G
A
K
V
--------
E
R
N
G
S
V
H
V
D
A
G
P
I
N
Q
Y
C
A
P
Y
D
L
V
K
T
M
R
A
S
I
W
A
L
G
P
L
V
A
R
F
G
Q
G
Q
V
S
L
P
G
G
C
A
I
G
A
R
P
V
D
L
H
I
H
G
L
E
Q
L
G
A
T
I
T
L
E
D
G
Y
-
V
K
A
H
V
D
-
G
R
-
L
Q
G
A
H
I
--
V
M
D
--
K
V
S
V
G
A
T
I
T
I
M
C
A
A
T
L
A
E
G
T
T
V
L
D
N
A
A
R
E
P
E
I
V
D
T
A
M
F
L
N
K
L
G
A
K
I
S
-
G
A
-
G
T
-
D
S
I
T
I
-
E
G
V
E
R
L
G
G
G
K
H
A
V
V
P
D
R
I
E
T
G
T
F
-
L
V
A
A
A
V
S
R
G
K
I
V
C
R
N
T
H
A
H
L
L
E
A
V
L
A
K
L
E
E
A
G
A
-
E
I
E
C
G
E
D
W
I
S
L
D
M
T
G
R
E
L
K
A
V
T
V
R
T
A
P
H
P
G
F
P
T
D
M
Q
A
Q
F
T
L
L
N
M
M
A
K
G
G
G
V
I
T
E
T
I
F
E
N
R
F
M
H
V
P
E
L
K
R
M
G
A
K
A
E
I
E
G
N
T
V
I
C
G
D
V
D
R
L
S
G
A
Q
V
M
A
T
D
L
R
A
S
A
S
L
V
I
A
G
C
I
A
K
G
E
T
I
V
D
R
I
Y
H
I
D
R
G
Y
E
R
I
E
D
K
L
S
A
L
G
A
N
I
E
R
F
R
26
PsiBlast_CBE
91.31
42%
-104
- C6 -
3VCY
4
MURA_VIBFM
B:
[1-414]
M
D
K
F
R
I
Q
G
S
D
K
P
L
S
G
E
V
T
I
S
G
A
K
N
A
A
L
P
I
L
F
A
S
L
L
A
-
E
E
P
V
-
E
V
A
N
V
P
K
L
R
D
V
D
T
T
M
E
L
L
K
R
L
G
A
E
V
S
--------
R
N
G
S
V
H
I
D
A
S
G
V
N
D
F
C
A
P
Y
D
L
V
K
T
M
R
A
S
I
W
A
L
G
P
L
V
A
R
F
G
K
G
Q
V
S
L
P
G
G
C
A
I
G
A
R
P
V
D
L
H
I
H
G
L
E
Q
L
G
A
T
I
K
L
-
E
E
G
Y
V
K
A
E
V
D
-
G
R
-
L
K
G
A
H
I
--
V
M
D
--
K
V
S
V
G
A
T
I
T
V
M
C
A
A
T
L
A
E
G
T
T
V
L
E
N
A
A
R
E
P
E
I
V
D
T
A
N
F
L
N
A
I
G
A
K
V
S
-
G
M
-
G
T
-
D
T
I
T
I
-
E
G
V
E
R
L
G
G
G
Y
H
E
V
V
A
D
R
I
E
T
G
T
F
-
L
V
A
A
A
V
S
G
G
K
I
V
C
K
N
T
K
A
H
L
L
E
A
V
L
A
K
L
E
E
A
G
A
-
D
V
Q
T
G
D
D
W
I
S
L
D
M
T
G
R
E
L
K
A
V
N
I
R
T
A
P
H
P
A
F
P
T
D
M
Q
A
Q
F
T
L
L
N
M
M
A
K
G
S
G
I
I
T
E
T
I
F
E
N
R
F
M
H
I
P
E
L
Q
R
M
G
A
H
A
E
I
E
G
N
T
A
I
C
G
D
T
D
G
L
S
G
A
Q
V
M
A
T
D
L
R
A
S
A
S
L
V
I
A
G
C
I
A
K
G
E
T
I
V
D
R
I
Y
H
I
D
R
G
Y
D
K
I
E
D
K
L
T
A
L
G
A
N
I
E
R
V
H
25
PsiBlast_CBE
91.28
42%
-102
- C6 -
3VCY
4
MURA_VIBFM
C:
[1-414]
M
D
K
F
R
I
Q
G
S
D
K
P
L
S
G
E
V
T
I
S
G
A
K
N
A
A
L
P
I
L
F
A
S
L
L
A
-
E
E
P
V
-
E
V
A
N
V
P
K
L
R
D
V
D
T
T
M
E
L
L
K
R
L
G
A
E
V
S
--------
R
N
G
S
V
H
I
D
A
S
G
V
N
D
F
C
A
P
Y
D
L
V
K
T
M
R
A
S
I
W
A
L
G
P
L
V
A
R
F
G
K
G
Q
V
S
L
P
G
G
C
A
I
G
A
R
P
V
D
L
H
I
H
G
L
E
Q
L
G
A
T
I
K
L
-
E
E
G
Y
V
K
A
E
V
D
-
G
R
-
L
K
G
A
H
I
--
V
M
D
--
K
V
S
V
G
A
T
I
T
V
M
C
A
A
T
L
A
E
G
T
T
V
L
E
N
A
A
R
E
P
E
I
V
D
T
A
N
F
L
N
A
I
G
A
K
V
S
-
G
M
-
G
T
-
D
T
I
T
I
-
E
G
V
E
R
L
G
G
G
Y
H
E
V
V
A
D
R
I
E
T
G
T
F
-
L
V
A
A
A
V
S
G
G
K
I
V
C
K
N
T
K
A
H
L
L
E
A
V
L
A
K
L
E
E
A
G
A
-
D
V
Q
T
G
D
D
W
I
S
L
D
M
T
G
R
E
L
K
A
V
N
I
R
T
A
P
H
P
A
F
P
T
D
M
Q
A
Q
F
T
L
L
N
M
M
A
K
G
S
G
I
I
T
E
T
I
F
E
N
R
F
M
H
I
P
E
L
Q
R
M
G
A
H
A
E
I
E
G
N
T
A
I
C
G
D
T
D
G
L
S
G
A
Q
V
M
A
T
D
L
R
A
S
A
S
L
V
I
A
G
C
I
A
K
G
E
T
I
V
D
R
I
Y
H
I
D
R
G
Y
D
K
I
E
D
K
L
T
A
L
G
A
N
I
E
R
V
H
10
PsiBlast_PDB
90.16
40%
-95
- C6 -
1A2N
1
MURA_ECOLI
A:
[1-413]
M
D
K
F
R
V
Q
G
P
T
K
-
L
Q
G
E
V
T
I
S
G
A
K
N
A
A
L
P
I
L
F
A
A
L
L
A
-
E
E
P
V
-
E
I
Q
N
V
P
K
L
K
D
V
D
T
S
M
K
L
L
S
Q
L
G
A
K
V
--------
E
R
N
G
S
V
H
I
D
A
R
D
V
N
V
F
C
A
P
Y
D
L
V
K
T
M
R
A
S
I
W
A
L
G
P
L
V
A
R
F
G
Q
G
Q
V
S
L
P
G
G
A
T
I
G
A
R
P
V
D
L
H
I
S
G
L
E
Q
L
G
A
T
I
K
L
-
E
E
G
Y
V
K
A
S
V
D
-
G
R
-
L
K
G
A
H
I
--
V
M
D
--
K
V
S
V
G
A
T
V
T
I
M
C
A
A
T
L
A
E
G
T
T
I
I
E
N
A
A
R
E
P
E
I
V
D
T
A
N
F
L
I
T
L
G
A
K
I
S
-
G
Q
-
G
T
D
R
I
V
-
I
-
E
G
V
E
R
L
G
G
G
V
Y
R
V
L
P
D
R
I
E
T
G
T
F
-
L
V
A
A
A
I
S
R
G
K
I
I
C
R
N
A
Q
P
D
T
L
D
A
V
L
A
K
L
R
D
A
G
A
-
D
I
E
V
G
E
D
W
I
S
L
D
M
H
G
K
R
P
K
A
V
N
V
R
T
A
P
H
P
A
F
P
T
D
M
Q
A
Q
F
T
L
L
N
L
V
A
E
G
T
G
F
I
T
E
T
V
F
E
N
R
F
M
H
V
P
E
L
S
R
M
G
A
H
A
E
I
E
S
N
T
V
I
C
H
G
V
E
K
L
S
G
A
Q
V
M
A
T
D
L
R
A
S
A
S
L
V
L
A
G
C
I
A
E
G
T
T
V
V
D
R
I
Y
H
I
D
R
G
Y
E
R
I
E
D
K
L
R
A
L
G
A
N
I
E
R
V
K
41
HHSearch
85.03
38%
-98
- C6 -
3ZH4
2
?
A:
[1-417]
M
R
K
I
V
I
N
G
G
L
-
P
L
Q
G
E
I
T
I
S
G
A
K
N
S
V
V
A
L
I
P
A
I
I
L
A
-
D
D
V
V
-
T
L
D
C
V
P
D
I
S
D
V
A
S
L
V
E
I
M
E
L
M
G
A
T
V
K
R
Y
D
D
-------
V
L
E
I
D
P
R
G
V
Q
N
I
P
M
P
---
I
N
S
L
R
A
S
Y
Y
F
Y
G
S
L
L
G
R
F
G
E
A
T
V
G
L
----
D
L
G
P
R
P
I
D
L
H
L
K
A
F
E
A
M
G
A
T
A
S
Y
-
E
G
D
N
M
K
L
S
A
K
D
T
G
-
L
H
G
A
S
I
--
Y
M
D
--
T
V
S
V
G
A
T
I
N
T
M
I
A
A
V
K
A
N
G
R
T
I
I
E
N
A
A
R
E
P
E
I
I
D
V
A
T
L
L
N
N
M
G
A
H
I
R
-
G
A
G
T
N
-
I
I
I
-
I
-
D
G
V
E
R
L
H
G
T
R
H
Q
V
I
P
D
R
I
E
A
G
T
Y
-
I
S
L
A
A
A
V
G
K
G
I
R
I
N
N
V
L
Y
E
H
L
E
G
F
I
A
K
L
E
E
M
G
V
-
R
M
T
V
S
E
D
S
I
F
V
E
E
Q
-
S
N
L
K
A
I
N
I
K
T
A
P
Y
P
G
F
A
T
D
L
Q
Q
P
L
T
P
L
L
L
R
A
N
G
R
G
T
I
V
D
T
I
Y
E
K
R
V
N
H
V
F
E
L
A
K
M
D
A
D
I
S
T
T
N
G
H
I
L
Y
T
G
G
R
D
L
R
G
T
S
V
K
A
T
D
L
R
A
G
A
A
L
V
I
A
G
L
M
A
E
G
K
T
E
I
T
N
I
E
F
I
L
R
G
Y
S
D
I
I
E
K
L
R
N
L
G
A
D
I
R
L
V
E
14
PsiBlast_PDB
84.60
38%
-97
- C6 -
3ZH4
2
?
A:
[1-416]
M
R
K
I
V
I
N
G
G
L
-
P
L
Q
G
E
I
T
I
S
G
A
K
N
S
V
V
A
L
I
P
A
I
I
L
A
-
D
D
V
V
-
T
L
D
C
V
P
D
I
S
D
V
A
S
L
V
E
I
M
E
L
M
G
A
T
V
K
-------
R
Y
D
D
V
L
E
I
D
P
R
G
V
Q
N
I
P
M
P
---
I
N
S
L
R
A
S
Y
Y
F
Y
G
S
L
L
G
R
F
G
E
A
T
V
G
L
----
D
L
G
P
R
P
I
D
L
H
L
K
A
F
E
A
M
G
A
T
A
S
Y
-
E
G
D
N
M
K
L
S
A
K
-
D
T
G
L
H
G
A
S
I
--
Y
M
D
--
T
V
S
V
G
A
T
I
N
T
M
I
A
A
V
K
A
N
G
R
T
I
I
E
N
A
A
R
E
P
E
I
I
D
V
A
T
L
L
N
N
M
G
A
H
I
R
-
G
A
-
G
T
-
N
I
I
-
I
I
D
G
V
E
R
L
H
G
T
R
H
Q
V
I
P
D
R
I
E
A
G
T
Y
I
S
L
A
A
A
V
G
K
G
-
I
R
I
N
N
V
L
Y
E
H
L
E
G
F
I
A
K
L
E
E
M
G
V
-
R
M
T
V
S
E
D
S
I
F
V
E
E
Q
S
-
N
L
K
A
I
N
I
K
T
A
P
Y
P
G
F
A
T
D
L
Q
Q
P
L
T
P
L
L
L
R
A
N
G
R
G
T
I
V
D
T
I
Y
E
K
R
V
N
H
V
F
E
L
A
K
M
D
A
D
I
S
T
T
N
G
H
I
L
Y
T
G
G
R
D
L
R
G
T
S
V
K
A
T
D
L
R
A
G
A
A
L
V
I
A
G
L
M
A
E
G
K
T
E
I
T
N
I
E
F
I
L
R
G
Y
S
D
I
I
E
K
L
R
N
L
G
A
D
I
R
L
V
E