@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : Wbm0750: (2015-12-04 )
MQVKTPTINPKFEKKNNLALIESIDLDFIPYACHYDEETILTKQGELLKIIKLEDYSSADNYSDLRTEIRKSISKNIDSLYFTVWIHTVRKRNKLSLKWNKTGDFSDKLHSTWLDKLTNSKLRYINELYIVILVSDFNKHSNNSFFFGGIRNKHKLSLQENHQELQRVTDLIQSDLEPFGAKKLALRFNGDKVYSEMIEFLHYIVTLTHKDHPICERDLSQYIKNLKIAFGFNTFQTIFENQQKFGSVFCIKEYREIPLGNIDRCLQLDSELIITEIIIFTSNNKAMKEFKKQINMLQVSEDNTLLRNSEIKEIIELEGTSTIDFCQQKIIFTIFADDRNRLAENISSLSSVMSLIGLMMFRTDLHMENHFWAQLPGNFAFVTQPKNILAKYACSFAMLHDFTSGTLKGGRWKEAVTVFFSKKGSPYFFNFHGKKNNGHTTILGAPNSGRTSLINFLLSESRKFNPRIIILDNTGKSIIFTKAVSGKYYIIDPKYKNKSLKFNPLNIEDSASNRSMLVELIKRMVADTSLVGIKEKIKKVVDSIFAIPRESRSISRISEMLLLLKGKISKWCGDGEFAYLFQDSDESDIDWKIKTISLNTANLTKHKECMSVILYYFLYSFEAQCDGSPAILVLDEAWEISSIFPTEEGFDNWMQRMTELNVVVILSTENLNLAFASEFTQYLDKHVDTRILMPNFNANRLYMKAFSLSKEELNIILQTPTQEGLFLIKQYKGLVTLNLDLKNIQEIHVLSANRETIKYMYEAIKEKGEEVNKWLPVFYGKCKT
Atome Classification :
(20 SA)
--.........10........20........30........40........50........60........70........80........90....-....100.......110...-....120.......130.......140.......150.......160.......170.......180.......190.......200.......210.......220.......230.......240.......250...-----....260.......270.......280.......290...-....300.......310.---......-.320.......330.......340.......350.......360...--....370.......380.......390.......400..--.....410.......420.......430--.---.......440.......450...-....460..-.----.....470.......480-.......490.......500.....----..--510......-.520....---...530.......540.......----------550........560.-----...----------------------.-------------..570.......580.......590-------....---...600........610.......620...------....630..-....-.640...--.---..--..650----.......------660......-----.670.....---..680.......---690.-..---.-...700-----.....-...710.......720.......730......---.740.-......750.......-760.......770.........780..
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
--MQVKTPTINPKFEKKN
N
L
A
L
I
E
SIDLDFIPYACHYDEETILTKQG
E
L
L
K
I
I
K
LEDYSSAD
N
Y
S
D
L
R
T
E
I
R
K
S
I
S
K
N
I
D
S
L
Y
F
T
V
W
I
H
T
V
RKR
N
K
L
-
S
L
K
WNKTGDF
S
D
K
L
H
S
T
W
L
D
-
K
LTN
S
K
L
R
Y
I
N
E
L
Y
I
V
I
L
V
SDFNKHSNN
S
F
F
F
GGIRN
K
H
K
L
S
L
Q
E
N
H
Q
E
L
Q
R
V
T
D
L
I
Q
SDLEPFGA
K
K
L
A
L
R
FN
G
D
K
V
Y
S
E
M
I
E
F
L
H
Y
I
V
T
LTHKDHP
I
C
E
R
D
L
S
Q
Y
I
KN
L
K
I
A
FG
F
N
T
F
Q
T
I
F
E
N
Q
Q
K
FG
S
V
F
C
I
K
E
Y
R-----EIPLG
N
I
D
R
C
L
QLDSE
L
I
I
T
E
I
I
I
F
TSN
N
K
A
M
K
E
F
K
K
QI
N
-
M
L
Q
VSEDNTLL
R
N
S
E
-
I
K
---
E
I
I
ELE-GT
S
T
I
D
F
C
QQ
K
I
I
F
T
I
FAD
D
R
N
R
L
A
E
N
I
S
S
L
S
S
V
M
S
L
I
G
L
M
M
F
R
T
DL--HMEN
H
F
W
A
QLPG
N
F
A
F
V
T
Q
P
K
N
I
L
A
K
Y
A
C
S
F
A
M
L
H
DFTS--GTLKGGRW
K
E
A
V
T
V
F
F
SKKGS
P
Y
F
F
N
F
---H---GKKNNG
H
T
T
I
L
GAPNS
G
R
T
S
L
I
N
-
F
L
L
S
ES-RK-F----N
P
R
I
I
I
LDNTG
K
S
I
I
F
T
K-AVSG
K
Y
Y
I
IDPKYKNKS
L
K
FNPLNI----ED--SAS
N
R
S
M
L
V
-
E
L
I
K
R
M
VA---DTSL
V
G
I
K
E
K
I
K
K
V
V
D
S
I
F
AIPR----------E-S
R
S
I
S
R
I
S
E
M
L
L
L
-----
L
K
G
----------------------
K
-------------
I
S
K
WCGDG
E
F
A
Y
L
FQDSDESDI
D
W
K
-------
I
K
T
I
---
S
LNT-
A
N
L
T
K
H
K
E
C
M
S
V
I
L
Y
Y
F
L
Y
S
FEAQC------DGS
P
A
I
L
V
L-DEAW-E
I
-
S
SIF--P---T
E
--
E
G
F
D
N
----
W
M
Q
R
M
TE------L
N
V
V
V
I
L
ST-----ENL
N
L
A
F
A
S
---
E
F
T
Q
Y
L
D
KHVD
T
---
R
I
LM-PN---F-NA
N
R
L
------
Y
M
K
A
F-SL
S
K
E
E
L
N
I
I
L
QTPTQE
G
L
F
L
I
K
QYK
G
L
V
T
L
N
---LDLKN-
I
Q
E
I
H
V
LSA
N
R
E
T
I
K
Y
-
M
Y
E
A
I
K
E
KG
E
E
--
V
N
K
W
L
P
V
FYGKCKT
47
Fugue
78.63
14%
-53
* C4 *
4NL4
3
?
H:
[18-747]
SV
A
H
V
A
L
P
V
P
L
P
R
-----------
T
F
D
Y
L
L
P
E
G
M
A
V
K
A
G
C
R
V
R
V
P
F
G
K
Q
E
R
I
G
I
V
A
A
V
S
E
R
---
S
E
L
P
L
D
E
L
K
P
V
A
E
A
L
D
D
E
--
P
V
F
S
T
T
V
W
R
L
L
M
W
-
A
A
E
Y
Y
H
H
-
P
I
G
D
V
L
F
H
A
L
P
V
-
M
L
R
Q
G
K
P
A
S
A
T
P
L
W
Y
W
F
A
T
E
Q
G
Q
V
V
D
L
N
G
-------------
L
K
R
S
R
K
Q
Q
Q
A
L
A
A
L
R
Q
G
K
I
W
R
H
Q
V
G
E
L
--
E
F
N
-
E
A
A
L
Q
A
L
R
G
K
G
L
A
E
L
A
C
E
A
T
D
W
R
---
S
A
Y
S
V
A
G
E
R
L
R
L
N
T
E
Q
A
T
A
V
G
A
I
H
S
A
A
D
R
F
S
A
W
L
L
A
G
I
T
GSGKT
E
V
Y
L
S
V
L
E
N
V
L
A
Q
G
R
Q
A
L
V
M
-
V
P
E
I
G
L
T
P
Q
T
I
A
R
F
R
Q
R
F
N
-
A
P
V
E
V
L
H
S
G
L
N
D
S
E
R
-
L
S
---
A
W
L
K
A
K
N
G
E
A
A
I
V
I
G
T
R
S
S
L
F
T
P
F
K
D
------------------
L
G
V
I
V
I
D
E
E
H
-----
D
S
S
Y
K
Q
Q
E
G
W
R
Y
H
A
R
D
L
A
V
W
R
A
H
S
E
Q
I
P
I
I
L
G
S
A
T
P
AL
E
T
L
H
N
V
R
Q
G
K
Y
R
Q
L
T
L
S
K
P
A
Q
Q
H
V
L
D
L
---
K
---
G
Q
P
L
Q
A
G
L
S
---------
P
A
L
I
S
-
R
M
R
Q
H
L
-
Q
A
-
D
----
N
Q
V
I
L
F
L
N
R
R
G
F
A
P
A
L
L
C
-
H
D
C
G
W
I
A
E
C
P
R
C
D
S
Y
Y
T
L
H
Q
A
Q
H
H
L
----
R
C
--
H
H
C
D
S
Q
R
P
I
-
P
R
Q
C
P
S
C
G
---
S
T
H
L
V
P
V
G
I
G
T
E
Q
L
E
Q
A
L
A
P
L
F
P
----------
E
--
V
P
I
S
R
I
-----------------------------------------------------------------
D
R
H
L
A
A
V
H
R
G
-------
G
A
R
I
---
L
I
G
T
-
Q
M
L
A
K
G
H
H
F
P
D
V
T
L
V
S
L
L
--------------------
D
V
-
D
G
A
L
--
F
-
S
A
D
F
--
R
---
S
A
--
E
R
F
A
Q
----
L
Y
T
Q
V
S
G
RAGRAG
K
Q
G
E
V
I
L
Q
T
HHPEH
P
L
L
Q
T
L
L
Y
K
---
G
Y
D
A
F
A
E
Q
A
L
A
E
---
R
Q
T
M
Q
L
P
---
P
-
W
T
S
H
V
------
L
I
R
A
E
-
D
H
N
N
Q
Q
A
P
L
F
L
Q
Q
L
R
N
L
L
Q
A
S
P
L
A
D
E
K
L
W
V
L
G
---
P
V
P
A
L
-
R
W
Q
I
L
L
Q
H
P
S
R
V
R
L
Q
H
-
I
V
S
G
T
L
A
L
I
N
T
--
L
P
E
A
W
V
L
D
V
D
P
I
E
G
45
Fugue
78.15
16%
-86
* C5 *
4AG6
3
?
A:
[3-385]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
G
I
N
D
G
S
G
I
V
L
G
K
D
R
D
G
G
L
V
L
V
D
I
WKR
G
---
G
D
R
T
N
S
N
W
T
I
L
A
K
P
G
A
G
K
S
F
T
A
K
M
L
L
L
R
E
Y
M
Q
-------
G
S
R
V
I
I
I
D
P
E
R
E
---
Y
K
E
M
C
R
K
L
G
G
V
W
I
N
--
C
T
G
G
E
G
K
I
N
P
L
Q
V
R
L
R
P
Q
S
--
P
L
A
L
H
I
Q
T
L
-
R
T
F
F
S
L
Y
L
---
R
D
L
T
D
T
E
K
A
A
L
E
D
A
L
V
E
V
Y
K
E
A
G
ITWDTDPRGV
P
-
N
D
K
W
P
T
V
K
E
L
Y
E
Y
-----
C
V
K
----------------------
K
A
E
ENPETY
G
R
L
S
V
L
L
K
R
A
A
E
G
A
D
S
Y
L
W
A
G
P
T
A
V
E
A
D
S
D
-------
F
I
V
F
D
VH
D
L
Q
N
-
A
E
D
Q
V
K
R
A
Q
Y
F
N
V
L
S
F
A
W
N
I
L
E
R
D
R
------
R
-
E
R
T
V
L
V
V
-
D
E
A
W
M
L
V
D
P
Q
T
P
--
Q
---
A
I
--
A
F
L
R
D
----
T
S
K
R
I
R
K
------
Y
N
G
S
L
I
V
I
S
-----
Q
N
V
I
D
F
L
A
P
---
E
V
Q
R
Y
G
Q
A
L
L
D
N
PT
Y
K
L
L
L
-
A
Q
---
G
-
E
K
D
L
E
------
A
I
T
T
L
M
N
L
S
E
A
E
H
D
L
L
V
N
A
K
R
G
E
G
L
F
V
A
G
T
Q
R
I
H
I
K
I
E
---
A
A
P
Y
E
M
Q
Y
------------------------------------------
54
Fugue
75.58
18%
-28
- C2 -
2BVL
8
TOXB_PEPDI
A:
[1-543]
--
M
S
L
V
N
---
R
K
Q
L
E
K
M
A
N
V
R
F
-
R
T
Q
E
D
E
Y
V
A
I
L
D
A
L
E
E
Y
H
N
M
S
E
N
T
V
V
E
K
Y
L
K
L
K
D
I
N
S
L
---
T
D
I
C
I
D
T
Y
K
K
S
G
R
N
K
A
L
K
K
F
K
E
Y
L
V
T
----
E
V
L
-
E
L
K
N
N
N
L
T
P
V
E
K
N
L
H
F
V
W
I
G
G
Q
I
N
D
T
A
I
N
Y
I
N
Q
W
K
D
V
----------
N
S
D
Y
N
V
N
V
F
Y
D
S
N
A
F
L
I
N
T
L
K
K
T
V
V
E
--
S
A
I
N
D
T
L
E
S
F
R
E
N
L
N
D
P
R
F
D
-------------------------------------
Y
N
K
F
F
R
K
R
M
E
I
I
Y
D
K
Q
K
N
F
I
N
Y
Y
K
A
Q
R
E
E
------------------
N
P
E
L
I
I
D
D
I
V
K
T
Y
L
S
N
E
Y
S
K
E
I
D
E
L
N
T
-
Y
I
E
E
S
L
N
K
I
T
Q
N
S
G
N
D
V
R
---
N
F
G
E
F
K
-
N
G
E
S
F
N
L
Y
E
Q
E
L
V
-----
E
R
W
N
L
A
A
A
S
D
I
L
R
I
S
A
L
K
E
I
G
G
M
Y
L
D
V
D
M
-----------
L
P
G
I
Q
P
D
L
F
E
S
I
E
K
P
S
S
V
T
V
D
F
W
E
M
T
K
L
E
A
--
I
M
K
Y
K
E
--------
Y
I
P
E
Y
T
S
E
H
F
D
M
L
---
D
---
E
E
V
Q
S
S
F
E
S
V
L
A
S
K
-
S
D
K
S
E
I
F
S
-
S
L
--
G
D
-
M
E
-
A
----
S
P
L
E
V
K
I
A
F
N
S
K
G
I
I
N
Q
G
-
L
I
S
V
K
--------------------------------
D
S
Y
C
S
-
N
L
I
V
K
Q
-----------
I
E
N
R
Y
K
I
L
N
N
S
L
N
P
A
I
S
----------
E
-
D
N
D
----------------------------------------------------------------------------------------------
F
N
T
-
T
T
N
T
F
I
D
S
I
M
A
E
----------
A
N
A
------
D
N
G
R
F
M
M
E
L
-
G
K
Y
L
-
R
V
-
G
-
F
F
--
P
----------------------
D
------
V
K
T
T
I
N
L
S
G
-----
P
E
A
Y
A
A
A
Y
Q
---
D
L
L
M
F
K
E
G
S
M
N
I
---
H
L
I
------------
E
A
------
D
L
R
N
F
-
E
I
S
K
T
N
I
S
---
Q
S
T
E
Q
E
M
A
S
L
--------------------------
W
S
F
D
D
A
R
A
K
A
-
Q
F
E
E
Y
K
R
N
Y
F
E
--
G
A
L
-----------
51
Fugue
75.37
19%
18
- C4 -
4OUA
8
?
B:
[4-557]
-----
L
L
A
T
V
G
P
T
G
G
V
K
N
R
L
D
I
V
D
F
V
R
-----------
D
E
K
F
F
T
L
Y
I
R
A
L
Q
A
I
Q
D
K
D
Q
S
D
Y
S
S
F
F
Q
L
S
G
---------
I
H
G
L
P
F
T
P
W
A
----
K
P
K
D
T
-
P
T
V
P
Y
E
S
G
------
Y
C
T
H
S
Q
-
V
L
F
P
T
W
H
R
V
Y
V
S
I
Y
E
Q
I
L
Q
E
A
A
K
G
I
A
K
K
F
-------
T
V
H
K
K
E
W
A
Q
A
A
E
D
L
R
----------
Q
P
Y
W
D
T
G
F
A
L
V
P
P
D
E
I
I
K
L
E
Q
V
K
I
T
N
Y
D
G
T
K
I
T
V
R
N
P
I
L
R
Y
S
F
H
P
I
D
P
S
F
N
G
Y
P
N
F
D
T
W
K
T
-------------------------
T
V
R
N
P
D
A
D
K
K
E
N
I
P
A
L
I
G
K
L
D
L
-----
E
A
D
S
T
R
E
K
T
Y
N
-
M
L
K
F
N
A
N
----------------------------------
W
E
A
F
S
N
H
G
E
F
D
D
T
H
A
N
S
L
E
A
V
H
D
D
I
H
G
F
V
G
R
G
A
I
RG
H
M
T
H
A
L
F
A
A
F
---------------------------------------------------
D
P
I
F
W
L
H
---
H
---
S
N
V
D
R
-
H
L
S
L
W
Q
A
L
Y
P
G
V
W
V
T
Q
G
-
P
E
R
E
G
S
-
M
G
-
F
----
A
P
G
T
E
L
N
K
D
S
----------------
A
L
E
P
F
Y
E
T
E
D
K
P
W
T
S
V
P
L
----
T
D
--
T
A
L
L
N
Y
S
Y
P
-
D
F
D
K
V
K
G
G
---
T
P
D
L
V
--
R
D
Y
I
N
D
H
I
D
R
R
Y
G
I
K
K
----------
S
-
E
G
G
K
N
P
A
Q
D
L
L
S
D
-----
F
K
G
----------------------
V
-----------------------------
T
H
D
H
N
E
D
L
K
-------
M
F
D
W
---
T
I
Q
A
-
S
W
K
K
F
E
L
D
D
S
F
A
I
I
F
Y
F
------
A
A
------
D
G
S
T
N
--
V
T
-
K
E
N
Y
--
I
-
G
S
I
N
--
I
-----------------
F
R
G
T
T
P
------
T
N
C
A
N
C
R
T
Q
-----
D
N
L
V
Q
E
G
F
V
---
H
L
D
R
F
I
A
R
D
L
D
T
--------
F
D
---
P
-
Q
A
V
H
R
------
Y
L
K
E
------
K
K
L
S
Y
K
V
V
A
D
D
H
S
------------------
V
T
L
K
S
-
L
-
R
I
R
V
Q
G
R
P
L
H
L
P
P
G
-
V
S
F
P
R
L
D
K
N
I
P
--
I
V
N
F
D
D
V
L
D
L
V
T
G
-
52
Fugue
69.33
14%
-29
- C5 -
2IUT
3
FTSK_PSEAE
A:
[70-477]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
P
P
L
S
L
L
D
P
A
E
V
K
Q
K
S
Y
S
P
E
S
L
E
A
M
S
R
--
L
L
E
I
K
L
K
E
F
G
V
E
V
S
V
D
S
V
H
P
G
P
V
I
T
R
F
E
I
Q
P
A
--
A
G
V
K
V
--
S
R
I
S
N
--
L
A
K
D
L
A
R
S
L
A
V
I
S
V
R
V
V
E
V
I
---
P
---
G
K
T
----
T
V
G
I
E
I
P
N
E
D
R
Q
M
V
R
F
-
S
E
V
L
S
S
-
P
E
-
Y
----
D
E
-----
H
K
S
T
V
P
L
A
L
G
H
-
D
I
G
G
R
P
I
I
T
D
L
A
K
M
P
H
L
L
V
A
G
T
T
G
S
----
G
K
--
S
V
G
V
N
A
M
L
L
-
S
I
L
F
K
S
T
P
---
S
E
A
R
L
I
M
I
D
P
K
M
L
E
L
S
I
Y
E
G
I
P
H
----------
L
L
C
P
V
V
T
D
M
K
E
A
A
N
A
-----
L
R
W
----------------------
S
-------------
V
A
E
M
E
R
R
Y
R
L
M
A
A
M
G
V
R
N
L
A
G
F
N
R
K
-------
V
K
D
A
---
E
E
A
G
-
T
P
L
T
D
P
L
F
R
R
E
S
-----
P
D
D
E
P
P
Q
L
------
S
T
L
P
T
I
V
V
V
V
D
E
F
A
-
D
M
-
M
M
I
V
G
K
K
---
V
E
--
E
L
I
A
R
----
I
A
Q
K
A
R
A
------
A
G
I
H
L
I
L
A
T
-----
Q
R
P
S
V
D
V
------
I
T
G
L
I
K
A
N
I
P
T
---
R
I
A
F
-
Q
-----------------------
V
S
S
K
I
D
S
R
T
I
L
D
Q
G
G
A
E
Q
L
L
---
G
H
G
D
M
L
Y
L
P
---
P
G
T
G
L
-
P
I
R
V
H
G
A
F
V
S
D
D
E
V
H
R
-
V
V
E
A
W
K
L
R
G
A
P
D
Y
I
E
D
I
L
A
G
-------
50
Fugue
65.95
12%
-14
- C1 -
4HHR
17
DOX1_ARATH
A:
[12-651]
-S
M
K
V
I
T
S
L
I
S
S
I
L
L
K
F
I
H
K
D
F
H
E
I
Y
A
------
R
M
S
L
L
D
R
F
L
L
L
I
V
H
G
V
D
K
M
V
P
W
H
K
L
P
V
F
L
G
L
T
Y
L
E
V
R
R
H
L
H
Q
Q
Y
N
L
L
N
V
G
Q
T
P
T
G
I
R
F
D
P
A
N
Y
P
-
Y
R
--
T
A
D
G
K
F
N
D
P
F
N
E
G
V
G
S
-
Q
N
S
F
F
G
-
R
N
C
P
P
V
D
--------------------------
Q
K
S
K
L
R
R
P
D
P
M
V
V
A
T
K
L
L
G
R
K
K
F
--------
I
D
T
G
K
Q
F
N
M
I
A
A
S
W
I
Q
F
M
I
H
D
W
I
D
H
L
E
D
T
H
Q
I
E
L
V
A
P
K
E
V
A
S
K
C
P
L
S
S
F
R
F
L
K
T
K
E
V
P
T
G
F
F
E
I
K
T
G
S
Q
-----
N
I
R
T
P
W
W
D
------------
S
S
V
I
Y
G
S
N
S
K
T
L
D
R
V
R
T
Y
K
D
G
K
L
K
I
S
E
E
T
G
L
L
L
H
D
E
-
D
G
---
L
A
--
I
S
-
G
D
I
R
N
S
W
A
G
V
S
A
L
Q
A
L
F
I
K
E
H
N
A
V
C
D
A
L
K
D
E
---------------------
D
D
D
L
-----
E
D
E
D
L
Y
R
Y
A
R
L
V
T
S
A
V
V
A
K
I
H
T
I
D
W
T
V
--
Q
L
L
K
--------
T
D
T
L
L
A
G
M
R
A
N
W
Y
G
L
---
L
---
G
K
K
F
K
D
S
F
G
H
A
G
----
S
S
I
L
G
G
V
-
V
G
M
K
K
P
-
Q
N
-
H
----
G
V
P
Y
S
L
T
E
D
F
T
S
V
Y
R
M
H
S
-
L
L
P
D
Q
L
H
I
L
D
I
D
D
V
P
G
--
T
N
K
S
L
P
L
----
I
Q
--
E
I
S
M
R
D
L
I
G
-
R
K
G
E
E
T
M
S
---
H
I
G
-------
F
T
K
L
M
V
S
M
G
H
Q
A
S
----------
G
-
A
L
E
L
M
N
Y
P
M
W
L
R
D
-----
I
V
P
----------------------
H
------------------------
D
P
N
G
Q
A
R
P
D
H
V
D
L
A
-------
A
L
E
I
---
Y
R
D
R
E
R
S
V
P
R
Y
N
E
F
R
R
S
M
F
M
I
P
I
T
K
W
E
D
L
T
------
E
D
E
E
A
I
E
V
L
-
D
D
V
Y
-
D
--------
G
---
D
V
--
E
E
L
D
L
----
L
V
G
L
M
A
E
------
K
K
I
K
G
F
A
I
S
-----
E
T
A
F
Y
I
F
L
I
---
M
A
T
R
R
L
E
---
A
D
---
R
F
F
T
-
S
D
---
F
-
N
E
T
I
Y
--------------
T
K
K
G
L
E
W
V
N
T
T
-
E
S
L
K
D
V
I
D
R
H
Y
P
D
M
T
D
K
W
---
M
N
S
E
S
-
A
F
S
V
W
D
S
P
P
L
T
K
N
P
I
P
-
L
Y
L
R
I
P
S
--------------------
20
HHSearch
59.78
9%
-64
- C3 -
1E9R
2
?
A:
[35-362]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
K
A
K
Q
V
T
V
A
G
---
V
PMP
R
D
A
E
P
R
H
L
L
V
N
G
A
T
G
T
G
K
S
V
L
L
R
-
E
L
A
Y
T
G
-
L
L
-
R
----
G
D
R
M
V
I
V
D
P
N
G
D
M
L
S
K
F
G
-
R
D
K
D
I
I
L
N
P
Y
D
---
Q
R
T
K
G
W
S
F
F
N
E
----
I
R
--
N
D
Y
D
W
Q
R
Y
A
L
S
V
V
P
R
G
K
T
D
E
A
E
E
W
A
S
Y
G
R
L
L
L
R
E
T
A
K
K
L
A
L
I
G
-------------
T
P
S
M
R
E
L
F
H
W
T
T
I
AT
F
D
D
L
R
G
F
L
EGTLA
E
S
L
F
A
GS
N
E
A
S
K
A
L
T
S
-------------
A
R
F
V
L
S
-
D
K
L
P
E
H
V
T
M
P
-
D
G
D
F
S
I
R
S
W
L
E
DPN
G
G
N
L
---
F
I
T
W
-
R
E
D
M
--
G
P
A
L
R
P
L
I
S
A
W
V
D
V
V
C
T
S
I
L
S
LPEE
P
K
R
R
L
W
L
F
I
-
D
E
L
A
-
S
L
-
E
---------
K
L
--
A
S
L
A
D
----
A
L
T
K
G
R
K
------
A
G
L
R
V
V
A
G
L
-----
Q
S
T
S
Q
L
D
D
V
YG
V
K
E
A
Q
T
L
R
A
S
F
R
S
---
L
V
V
L
-
G
G
SRT
D
P
K
T
N
E
D
------
M
S
L
S
L
-
G
E
H
E
V
E
R
D
R
A
L
E
R
V
R
E
R
V
V
M
P
A
E
I
A
N
L
P
D
L
T
A
---
Y
V
G
F
A
-
G
N
R
P
I
A
K
V
P
L
E
I
K
Q
F
A
-
N
R
Q
P
A
F
V
E
G
T
-----------------
5
PsiBlast_PDB
43.63
33%
26
- C3 -
2CV8
1
ENDA_SULTO
A:
[6-101]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
K
D
---
K
I
L
I
-
K
N
---
I
-
E
D
A
R
L
I
Y
K
M
GY
Y
G
K
P
I
-
G
-------
S
E
L
I
L
S
L
I
E
G
V
Y
L
V
K
K
G
K
L
E
I
V
S
N
G
E
R
L
D
F
E
R
-
L
Y
Q
I
G
V
T
Q
I
P
R
F
R
I
L
Y
S
V
Y
E
D
L
R
E
K
G
Y
V
--
V
R
S
G
I
K
Y
G
A
D
F
A
V
Y
48
Fugue
42.67
22%
36
- C5 -
3FBL
1
Y132_AFV1Y
A:
[1-82]
--------------------------------------------------------------------------------
Y
H
K
L
R
L
A
I
K
E
I
C
K
T
D
G
I
P
N
I
K
W
G
M
Y
I
A
F
G
E
K
L
L
K
S
Y
L
K
-
M
K
A
G
S
A
S
S
D
M
I
A
E
Y
I
N
N
A
I
S
A
F
S
S
R
T
G
I
S
-----------------
Q
E
T
A
Q
K
I
A
D
F
I
T
S
N
Y
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
26
HHSearch
40.62
18%
48
- C3 -
2IUT
-
FTSK_PSEAE
A:
[343-410]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
T
I
V
V
V
V
-
D
E
F
A
-
D
M
-
M
---------
M
I
V
G
K
K
V
E
E
L
I
A
R
I
A
Q
K
A
R
A
------
A
G
I
H
L
I
L
A
T
-----
Q
R
P
S
V
D
------
V
I
T
G
L
I
K
A
N
I
P
T
---
R
I
A
F
-
Q
V
---
S
-------------------------------------------------------------------------------------------------------
37
HHSearch
38.19
14%
12
- C3 -
2R2A
-
?
A:
[86-151]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
I
G
S
I
V
I
V
-
D
E
A
Q
-
D
V
-
W
P
A
R
--
S
AGS
K
I
--
P
E
N
V
Q
----
W
L
N
T
H
R
H
------
Q
G
I
D
I
F
V
L
T
-----
Q
G
P
K
L
L
D
Q
--------
N
L
R
T
L
V
R
K
---
H
Y
H
I
-
A
S
---
N
-
K
M
G
M
R
------
T
L
L
E
W
-
K
I
C
A
D
D
P
V
K
M
A
S
S
A
F
S
S
I
Y
T
L
D
K
K
V
Y
D
L
Y
E
S
------------------------------------------------------
21
HHSearch
37.90
17%
148
- C3 -
2IUS
-
FTSK_ECOLI
A:
[965-1026]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
V
V
L
G
K
------
D
I
A
G
E
P
V
V
A
D
L
---
A
------
K
M
P
H
L
L
V
A
G
T
T
G
S
G
A
S
V
G
V
N
-
A
M
I
L
S
M
-
L
Y
-
K
AQPE
D
V
R
F
I
M
I
D
P
K
M
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
1
PsiBlast_PDB
37.05
30%
144
- C3 -
1WFV
-
A:
[32-86]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
E
Y
K
M
D
L
Y
-
V
L
R
L
A
E
D
G
P
A
I
R
N
G
R
-
M
R
VGD
Q
I
I
E
I
N
-
G
E
S
T
R
D
M
T
H
A
R
A
I
E
L
I
K
S
G
G
R
R
V
R
L
L
L
K
R
G
T
G
S
G
P
S
S
G
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
44
HHSearch
36.67
17%
150
* C3 *
2DR3
1
Y284_PYRHO
A:
[22-62]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
R
N
V
V
L
L
S
G
G
P
G
T
G
K
T
I
F
S
Q
-
Q
F
L
W
N
G
-
L
K
-
M
----
G
E
P
G
I
Y
V
A
L
E
E
H
P
V
Q
V
R
Q
-
N
M
A
Q
F
G
W
D
V
K
P
Y
E
E
K
G
M
F
A
M
V
D
A
F
T
----
A
G
--
I
G
K
E
Y
E
K
Y
I
-
V
H
D
L
T
D
I
R
---
E
F
I
E
V
L
R
Q
A
I
R
D
I
N
A
K
R
V
V
V
D
S
V
----------
T
-
T
L
Y
I
N
K
P
A
M
A
R
S
I
-----
I
L
Q
----------------------
L
-------------
K
R
V
L
A
G
T
G
C
T
S
I
F
V
S
Q
V
S
G
F
G
P
G
V
E
-------
H
G
V
D
---
G
I
I
R
-
L
D
L
D
E
I
D
G
E
L
K
R
S
L
I
V
W
K
M
R
G
T
S
H
S
------
M
R
R
H
P
F
D
I
T
-
D
K
G
I
-
I
V
-
Y
P
D
K
--
V
---
L
K
--
R
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
32
HHSearch
35.78
12%
185
- C3 -
2ORV
1
KITH_HUMAN
A:
[18-57]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
G
Q
I
Q
V
I
L
G
P
M
F
S
G
K
S
T
E
L
M
-
R
R
V
R
R
F
-
Q
I
-
A
----
Q
Y
K
C
L
V
I
K
Y
A
K
D
T
R
Y
M
E
A
-
L
P
A
C
L
L
R
D
V
A
Q
E
A
L
G
V
A
V
I
G
I
D
E
G
Q
----
F
F
--
P
D
I
V
E
F
C
E
A
-
M
A
N
A
G
K
T
V
---
I
V
A
A
L
D
G
T
F
Q
R
K
P
F
G
A
I
L
N
L
V
P
L
----------
A
-
E
S
V
V
K
L
T
A
V
C
M
E
C
-----
F
R
E
----------------------
A
-------------
A
Y
T
K
R
L
G
T
E
K
E
V
E
V
I
G
G
A
D
K
Y
H
S
V
C
-------
R
L
C
Y
---
F
K
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
12
PsiBlast_PDB
35.17
31%
187
- C3 -
2B9B
2
?
A:
[421-481]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
S
I
D
P
L
D
I
----
S
Q
N
L
A
A
V
N
K
S
L
S
D
-
A
L
Q
H
L
A
Q
S
---
D
T
Y
L
S
A
I
E
D
K
I
E
E
I
L
S
K
I
Y
H
I
E
N
----------
E
----
I
A
R
I
K
K
L
I
G
E
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
31
HHSearch
34.87
12%
158
- C3 -
2B8T
1
KITH_UREPA
A:
[11-51]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
G
W
I
E
F
I
T
G
P
M
F
A
G
K
T
A
E
L
I
-
R
R
L
H
R
L
-
E
Y
-
A
----
D
V
K
Y
L
V
F
K
P
K
I
D
T
R
S
I
R
N
-
I
Q
S
R
T
G
T
S
L
P
S
V
E
V
E
S
A
P
E
I
L
N
Y
I
M
----
S
N
--
S
F
N
D
E
T
K
V
I
-
G
I
D
E
V
Q
F
F
---
D
D
R
I
C
E
V
A
N
I
L
A
E
N
G
F
V
V
I
I
S
G
L
----------
D
-
K
N
F
K
G
E
P
F
G
P
I
A
K
-----
L
F
T
----------------------
Y
-------------
A
D
K
I
T
K
L
T
A
I
C
N
E
C
G
A
E
A
T
H
S
L
R
K
I
-------
D
G
K
H
---
A
D
Y
N
-
D
D
I
V
K
I
G
C
Q
E
F
Y
S
A
V
C
R
H
H
H
K
V
P
N
R
------
P
Y
L
N
S
N
S
E
E
-
F
I
K
F
-
F
K
-
N
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
14
PsiBlast_PDB
34.83
31%
195
- C3 -
4WSG
1
?
A:
[421-479]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
P
I
D
P
L
D
I
----
S
Q
N
L
A
A
V
N
K
S
L
S
D
-
A
L
Q
H
L
A
Q
S
---
D
T
Y
L
S
A
I
E
D
K
I
E
E
I
L
S
K
I
Y
H
I
E
N
----------
E
----
I
A
R
I
K
K
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
42
HHSearch
34.69
2%
166
- C3 -
1CR0
1
A:
[34-77]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
G
E
V
I
M
V
T
S
G
S
G
M
G
K
S
T
F
V
R
-
Q
Q
A
L
Q
W
-
G
T
A
M
----
G
K
K
V
G
L
A
M
L
E
E
S
V
E
E
T
A
E
-
D
L
I
G
L
H
N
R
V
R
L
R
Q
S
D
S
L
K
R
E
I
I
E
N
G
----
K
F
--
D
Q
W
F
D
E
L
F
G
-
N
D
T
F
H
L
Y
D
---
S
F
A
E
A
E
T
D
R
L
L
A
K
L
A
Y
M
R
S
G
L
G
C
----------
D
-
V
I
I
L
D
H
I
S
I
R
K
M
I
-----
D
N
L
----------------------
M
-------------
T
K
L
K
G
F
A
K
S
T
G
V
V
L
V
V
I
C
H
L
K
D
L
R
G
-------
A
L
R
Q
---
L
S
D
T
-
I
I
A
L
E
R
N
Q
L
V
L
V
R
I
L
K
C
R
F
T
G
D
T
G
I
------
A
G
Y
M
E
Y
N
K
E
-
T
G
W
L
-
E
P
-
S
S
Y
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
18
PsiBlast_PDB
34.08
28%
119
- C3 -
3A5Y
1
EPMA_ECOLI
A:
[242-303]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
A
Q
I
S
T
E
D
H
R
V
A
E
R
-
F
E
V
Y
Y
K
G
I
E
L
A
N
G
F
H
E
L
T
D
A
R
E
Q
Q
Q
R
F
E
Q
D
N
R
K
R
A
A
R
-----
G
L
P
Q
H
P
I
D
Q
N
L
I
E
A
L
K
V
G
M
P
D
C
S
G
V
A
L
G
V
D
R
L
V
M
L
A
L
G
A
E
-
T
L
A
E
V
I
A
F
S
V
D
R
A
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------