@TOME V2.3
(Nov 2016)
Ref.
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : SA0147: (2016-03-12 )
MAHLSVKLRLLILALIDSLIVTFSVFVSYYILEPYFKTYSVKLLILAAISLFISHHISAFIFNMYHRAWEYASVSELILIVKAVTTSIVITMVVVTIVTGNRPFFRLYLITWMMHLILIGGSRLFWRIYRKYLGGKSFNKKPTLVVGAGQAGSMLIRQMLKSDEMKLEPVLAVDDDEHKRNITITEGVKVQGKIADIPELVRKYKIKKIIIAIPTIGQERLKEINNICHMDGVELLKMPNIEDVMSGELEVNQLKKVEVEDLLGRDPVELDMDMISNELTNKTILVTGAGGSIGSEICRQVCNFYPERIILLGHGENSIYLINRELRNRFGKNVDIVPIIADVQNRARMFEIMETYKPYAVYHAAAHKHVPLMEDNPEEAVHNNILGTKNTAEAAKNAEVKKFVMISTDKAVNPPNVMGASKRIAEMIIQSLNDETHRTNFVAVRFGNVLGSRGSVIPLFKSQIEEGGPVTVTHPEMTRYFMTIPEASRLVLQAGALAEGGEVFVLDMGEPVKIVDLARNLIKLSGKKEDDIRITYTGIRPGEKMFEELMNKDEVHPEQVFEKIYRGKVQHMKCNEVEAIIQDIVNDFSKEKIINYANGKKGDNYVR
Atome Classification :
(20 SA)
.........10........20........30........40........50........60........70........80........90........100.......110.......120.......130.......140.......150.......160.......170.......180.......190.......200.......210.......220.......230.......240.......250.......260.......270.......280.......290.......300...-.-...310....---...320........330.......340.......350.......360.......370.......380.......390....-..---------.----400.......410------------------------.......420....--...430..--.--------....440.......450...----....460...-.-...470-.......480.......490......-----.500.......--510...-....520.......530.......540.......550.......560....--...570.......580.......590.......600.....--------
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MAHL
S
V
K
L
R
L
L
I
L
A
L
I
D
S
L
I
V
T
F
S
V
F
V
S
Y
Y
I
L
E
P
Y
F
K
T
Y
S
V
K
L
L
I
L
A
A
I
S
L
F
I
S
H
H
I
S
A
F
I
F
N
M
Y
H
R
A
W
E
Y
A
S
V
S
E
L
I
L
I
V
K
A
V
T
T
S
I
V
I
T
M
V
V
V
T
I
VTGNR
P
F
F
R
L
Y
L
I
T
W
M
M
H
L
I
L
IGG
S
R
L
F
W
R
I
Y
R
K
Y
LGGKSFNKKP
T
L
V
V
GAG
Q
A
G
S
M
L
I
R
Q
M
L
KSDEMKL
E
P
V
L
A
VDDDEHKR
N
I
T
ITEG
V
K
V
QGKIA
D
I
P
E
L
V
R
K
YK
I
K
K
I
I
I
AIPTI
G
Q
E
R
L
K
E
I
N
N
I
CHMDG
V
E
LLKMP
N
I
E
D
V
MSGE
L
E
V
N
Q
L
K
K
V
E
V
E
D
L
LGRD
P
V
E
L
D
M
D
M
I
S
N
ELTN
K
T
I
L
V
TGAGG
S
I
G
S
E
I
C
R
Q
V
C
N
FY-P-
E
R
I
I
L
L
GHGE---
N
S
I
Y
L
-I
N
R
E
L
R
N
RFGKNV
D
I
V
P
I
I
A
D
V
Q
N
R
A
R
M
F
E
I
M
E
TYKP
Y
A
V
Y
HAAAHKHVPLMEDN
P
E
E
A
V
H
NNILGTK
N
T
A
E
AAK-NA---------
E
----
V
K
K
F
V
M
I
STDKAV------------------------NPPNVM
G
A
S
K
R
I
A
E
--
M
I
I
Q
SLND--E--------THR
T
N
F
V
A
V
R
F
G
N
VLGSRG
S
----
V
I
P
L
F
K
S
Q
IE-E-GG
P
V
T
V
-T
H
P
E
M
T
R
Y
F
M
TIP
E
A
S
R
L
V
L
QAGALA-----EG
G
E
V
F
V
L
DMG--EP
V
K
I
V
-
D
L
A
R
N
L
I
K
LSGKKED
D
I
R
I
T
Y
TGIR
P
G
E
K
M
F
E
E
L
M
N
KDEV
H
P
E
Q
V
F
E
K
I
Y
R--GKVQHMK
C
N
E
V
E
A
I
I
Q
D
I
V
N
D
F
S
K
E
K
I
I
NYANGKKGDNYVR--------
7
PsiBlast_PDB
92.45
36%
-63
- C1 -
4G5H
15
?
A:
[25-289]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
K
I
L
L
I
T
G
G
T
G
S
F
G
N
A
V
M
K
R
F
L
D
S
N
-
I
-
K
E
I
R
I
F
S
R
D
E
---
K
K
-----
Q
D
D
I
R
K
K
Y
N
-
N
S
K
L
K
F
Y
I
G
D
V
R
D
S
Q
S
V
E
T
A
M
R
D
V
D
--
Y
V
F
H
A
A
A
L
K
Q
V
P
S
C
E
F
F
P
V
E
A
V
K
T
N
I
I
G
T
E
N
V
L
Q
S
A
I
-
H
Q
---------
N
----
V
K
K
V
I
C
L
S
T
D
K
A
A
------------------------
Y
P
I
N
A
M
G
I
S
K
A
M
M
E
K
V
F
V
A
K
S
R
N
I
--
R
--------
S
E
Q
T
L
I
C
G
T
R
Y
G
N
V
M
A
S
R
G
S
----
V
I
P
L
F
I
D
K
I
K
-
A
-
G
E
P
L
T
I
-
T
D
P
D
M
T
R
F
L
M
S
L
E
D
A
V
E
L
V
V
H
A
F
K
H
A
-----
E
T
G
D
I
M
V
--
Q
K
--
A
P
S
S
T
V
G
D
L
A
T
A
L
L
E
L
F
---
E
A
D
N
A
I
E
I
I
G
T
R
H
G
E
K
K
A
E
T
L
L
T
R
E
E
---------------------------------------------------------------
26
PsiBlast_CBE
92.36
36%
-63
- C1 -
3W1V
7
?
B:
[25-289]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
K
I
L
L
I
T
G
G
T
G
S
F
G
N
A
V
M
K
R
F
L
D
S
N
-
I
-
K
E
I
R
I
F
S
R
D
E
---
K
K
-----
Q
D
D
I
R
K
K
Y
N
-
N
S
K
L
K
F
Y
I
G
D
V
R
D
S
Q
S
V
E
T
A
M
R
D
V
D
--
Y
V
F
H
A
A
A
L
K
Q
V
P
S
C
E
F
F
P
V
E
A
V
K
T
N
I
I
G
T
E
N
V
L
Q
S
A
I
-
H
Q
---------
N
----
V
K
K
V
I
C
L
S
T
D
K
A
A
------------------------
Y
P
I
N
A
M
G
I
S
K
A
M
M
E
KV
F
V
A
K
S
R
N
I
--
R
--------
S
E
Q
T
L
I
C
G
T
R
Y
G
N
V
M
A
S
R
G
S
----
V
I
P
L
F
I
D
K
I
K
-
A
-
G
E
P
L
T
I
-
T
D
P
D
M
T
R
F
L
M
S
L
E
D
A
V
E
L
V
V
H
A
F
K
H
A
-----
E
T
G
D
I
M
V
--
Q
K
--
A
P
S
S
T
V
G
D
L
A
T
A
L
L
E
L
F
---
E
A
D
N
A
I
E
I
I
G
T
R
H
G
E
K
K
A
E
T
L
L
T
R
E
E
---------------------------------------------------------------
6
PsiBlast_PDB
91.93
36%
-61
- C1 -
3W1V
7
?
A:
[25-289]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
K
I
L
L
I
T
G
G
T
G
S
F
G
N
A
V
M
K
R
F
L
D
S
N
-
I
-
K
E
I
R
I
F
S
R
D
E
---
K
K
-----
Q
D
D
I
R
K
K
Y
N
-
N
S
K
L
K
F
Y
I
G
D
V
R
D
S
Q
S
V
E
T
A
M
R
D
V
D
--
Y
V
F
H
A
A
A
L
K
Q
V
P
S
C
E
F
F
P
V
E
A
V
K
T
N
I
I
G
T
E
N
V
L
Q
S
A
I
-
H
Q
---------
N
----
V
K
K
V
I
C
L
S
T
D
K
A
A
------------------------
Y
P
I
N
A
M
G
I
S
K
A
M
M
E
K
V
F
V
A
K
S
R
N
I
--
R
--------
S
E
Q
T
L
I
C
G
T
R
Y
G
N
V
M
A
S
R
G
S
----
V
I
P
L
F
I
D
K
I
K
-
A
-
G
E
P
L
T
I
-
T
D
P
D
M
T
R
F
L
M
S
L
E
D
A
V
E
L
V
V
H
A
F
K
H
A
-----
E
T
G
D
I
M
V
--
Q
K
--
A
P
S
S
T
V
G
D
L
A
T
A
L
L
E
L
F
---
E
A
D
N
A
I
E
I
I
G
T
R
H
G
E
K
K
A
E
T
L
L
T
R
E
E
---------------------------------------------------------------
8
PsiBlast_PDB
90.46
36%
-67
- C1 -
3VVC
6
?
A:
[25-309]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
K
I
L
L
I
T
G
G
T
G
S
F
G
N
A
V
M
K
R
F
L
D
S
N
-
I
-
K
E
I
R
I
F
S
R
D
E
---
K
K
-----
Q
D
D
I
R
K
K
Y
N
-
N
S
K
L
K
F
Y
I
G
D
V
R
D
S
Q
S
V
E
T
A
M
R
D
V
D
--
Y
V
F
H
A
A
A
L
K
Q
V
P
S
C
E
F
F
P
V
E
A
V
K
T
N
I
I
G
T
E
N
V
L
Q
S
A
I
-
H
Q
---------
N
----
V
K
K
V
I
C
L
S
T
D
E
A
A
------------------------
Y
P
I
N
A
M
G
I
S
K
A
M
M
E
K
V
F
V
A
K
S
R
N
I
--
R
--------
S
E
Q
T
L
I
C
G
T
R
Y
G
N
V
M
A
S
R
G
S
----
V
I
P
L
F
I
D
K
I
K
-
A
-
G
E
P
L
T
I
-
T
D
P
D
M
T
R
F
L
M
S
L
E
D
A
V
E
L
V
V
H
A
F
K
H
A
-----
E
T
G
D
I
M
V
--
Q
K
--
A
P
S
S
T
V
G
D
L
A
T
A
L
L
E
L
F
---
E
A
D
N
A
I
E
I
I
G
T
R
H
G
E
K
K
A
E
T
L
L
T
R
E
E
---------------------------------------------------------------
9
PsiBlast_PDB
88.46
36%
-60
- C1 -
4J2O
2
?
A:
[21-308]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
K
D
K
V
L
L
I
T
G
G
T
G
S
F
G
N
A
V
L
K
R
F
L
E
T
D
-
I
-
K
E
I
R
I
F
S
R
D
E
---
K
K
-----
Q
D
D
M
R
K
K
Y
-
H
S
A
K
L
K
F
Y
I
G
D
V
R
D
Y
N
S
I
--
L
N
A
T
R
G
V
D
Y
I
Y
H
A
A
A
L
K
Q
V
P
S
C
E
F
H
P
M
E
A
V
K
T
N
V
L
G
T
E
N
V
L
E
A
A
I
-
Q
N
---------
H
----
V
K
R
V
V
C
L
S
T
D
K
A
V
------------------------
Y
P
I
N
A
M
G
I
S
K
A
M
M
E
K
V
M
V
A
K
S
R
N
L
--
E
--------
G
L
D
T
V
I
C
G
T
R
Y
G
N
V
M
A
S
R
G
S
----
V
I
P
L
F
V
D
Q
I
R
-
Q
-
G
K
P
L
T
I
-
T
D
P
N
M
T
R
F
M
M
T
L
E
D
A
V
D
L
V
L
Y
A
F
E
H
G
-----
E
N
G
D
I
F
V
-
Q
K
A
--
P
A
A
T
I
A
-
V
L
A
E
A
L
K
Q
L
L
N
V
E
D
H
P
I
S
I
--
M
G
T
R
H
G
E
K
A
F
E
A
L
L
S
R
E
E
---------------------------------------------------------------
1
PsiBlast_PDB
86.91
34%
-65
- C1 -
2GN4
3
PSEB_HELPY
A:
[17-294]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
M
L
D
N
Q
T
I
L
I
T
G
G
T
G
S
F
G
K
C
F
V
R
K
V
L
D
T
T
N
A
-
K
K
I
I
V
Y
S
R
D
E
L
K
Q
S
E
M
A
M
-
E
F
N
D
P
R
M
R
F
--------
F
I
G
D
V
R
D
L
E
R
L
N
Y
A
L
E
G
V
D
--
I
C
I
H
A
A
A
L
K
H
V
P
I
A
E
Y
N
P
L
E
C
I
K
T
N
I
M
G
A
S
N
V
I
N
A
C
L
-
K
N
---------
A
----
I
S
Q
V
I
A
L
S
T
D
K
A
A
------------------------
N
P
I
N
L
Y
G
A
T
K
L
C
S
D
--
K
L
F
V
S
A
N
N
FK
G
--------
S
S
Q
T
Q
F
S
V
V
R
Y
G
N
V
V
G
S
R
G
S
----
V
V
P
F
F
K
K
L
V
Q
N
K
-
A
S
E
I
P
I
-
T
D
I
R
M
T
R
F
W
I
T
L
D
E
G
V
S
F
V
L
K
S
L
K
R
M
-----
H
G
G
E
I
F
V
P
K
I
P
--
S
-
M
K
M
T
-
D
L
A
K
A
L
A
P
N
T
P
T
K
-------
I
I
G
I
R
P
G
E
K
L
H
E
V
M
I
P
K
D
E
S
H
L
A
L
E
F
E
D
F
F
----------------------------------------------------
24
PsiBlast_CBE
86.23
34%
-67
- C1 -
2GN6
3
PSEB_HELPY
B:
[18-294]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
L
D
N
Q
T
I
L
I
T
G
G
T
G
S
F
G
K
C
F
V
R
K
V
L
D
T
T
N
A
-
K
K
I
I
V
Y
S
R
D
E
L
K
Q
S
E
M
A
M
-
E
F
N
D
P
R
M
R
F
--------
F
I
G
D
V
R
D
L
E
R
L
N
Y
A
L
E
G
V
D
--
I
C
I
H
A
A
A
L
K
H
V
P
I
A
E
Y
N
P
L
E
C
I
K
T
N
I
M
G
A
S
N
V
I
N
A
C
L
-
K
N
---------
A
----
I
S
Q
V
I
A
L
S
T
D
K
A
A
------------------------
N
P
I
N
L
Y
G
A
T
K
L
C
S
D
--
K
L
F
V
S
A
N
N
FK
G
--------
S
S
Q
T
Q
F
S
V
V
R
Y
G
N
V
V
G
S
R
G
S
----
V
V
P
F
F
K
K
L
V
Q
N
K
-
A
S
E
I
P
I
-
T
D
I
R
M
T
R
F
W
I
T
L
D
E
G
V
S
F
V
L
K
S
L
K
R
M
-----
H
G
G
E
I
F
V
P
K
I
P
--
S
-
M
K
M
T
-
D
L
A
K
A
L
A
P
N
T
P
T
K
-------
I
I
G
I
R
P
G
E
K
L
H
E
V
M
I
P
K
D
E
S
H
L
A
L
E
F
E
D
F
F
----------------------------------------------------
5
PsiBlast_PDB
86.11
34%
-65
- C1 -
2GNA
2
PSEB_HELPY
A:
[17-294]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
M
L
D
N
Q
T
I
L
I
T
G
G
T
G
S
F
G
K
C
F
V
R
K
V
L
D
T
T
N
A
-
K
K
I
I
V
Y
S
R
D
E
L
K
Q
S
E
M
A
M
-
E
F
N
D
P
R
M
R
F
--------
F
I
G
D
V
R
D
L
E
R
L
N
Y
A
L
E
G
V
D
--
I
C
I
H
A
A
A
L
K
H
V
P
I
A
E
Y
N
P
L
E
C
I
K
T
N
I
M
G
A
S
N
V
I
N
A
C
L
-
K
N
---------
A
----
I
S
Q
V
I
A
L
S
T
D
K
A
A
------------------------
N
P
I
N
L
Y
G
A
T
K
L
C
S
D
--
K
L
F
V
S
A
N
N
FK
G
--------
S
S
Q
T
Q
F
S
V
V
R
Y
G
N
V
V
G
S
R
G
S
----
V
V
P
F
F
K
K
L
V
Q
N
K
-
A
S
E
I
P
I
-
T
D
I
R
M
T
R
F
W
I
T
L
D
E
G
V
S
F
V
L
K
S
L
K
R
M
-----
H
G
G
E
I
F
V
P
K
I
P
--
S
-
M
K
M
T
-
D
L
A
K
A
L
A
P
N
T
P
T
K
-------
I
I
G
I
R
P
G
E
K
L
H
E
V
M
I
P
K
D
E
S
H
L
A
L
E
F
E
D
F
F
----------------------------------------------------
4
PsiBlast_PDB
85.52
34%
-60
- C1 -
2GN9
2
PSEB_HELPY
A:
[17-294]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
M
L
D
N
Q
T
I
L
I
T
G
G
T
G
S
F
G
K
C
F
V
R
K
V
L
D
T
T
N
A
-
K
K
I
I
V
Y
S
R
D
E
L
K
Q
S
E
M
A
M
-
E
F
N
D
P
R
M
R
F
--------
F
I
G
D
V
R
D
L
E
R
L
N
Y
A
L
E
G
V
D
--
I
C
I
H
A
A
A
L
K
H
V
P
I
A
E
Y
N
P
L
E
C
I
K
T
N
I
M
G
A
S
N
V
I
N
A
C
L
-
K
N
---------
A
----
I
S
Q
V
I
A
L
S
T
D
K
A
A
------------------------
N
P
I
N
L
Y
G
A
T
K
L
C
S
D
--
K
L
F
V
S
A
N
N
FK
G
--------
S
S
Q
T
Q
F
S
V
V
R
Y
G
N
V
V
G
S
R
G
S
----
V
V
P
F
F
K
K
L
V
Q
N
K
-
A
S
E
I
P
I
-
T
D
I
R
M
T
R
F
W
I
T
L
D
E
G
V
S
F
V
L
K
S
L
K
R
M
-----
H
G
G
E
I
F
V
P
K
I
P
--
S
-
M
K
M
T
-
D
L
A
K
A
L
A
P
N
T
P
T
K
-------
I
I
G
I
R
P
G
E
K
L
H
E
V
M
I
P
K
D
E
S
H
L
A
L
E
F
E
D
F
F
----------------------------------------------------
23
PsiBlast_CBE
85.40
34%
-62
- C1 -
2GN8
3
PSEB_HELPY
B:
[17-294]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
M
L
D
N
Q
T
I
L
I
T
G
G
T
G
S
F
G
K
C
F
V
R
K
V
L
D
T
T
N
A
-
K
K
I
I
V
Y
S
R
D
E
L
K
Q
S
E
M
A
M
-
E
F
N
D
P
R
M
R
F
--------
F
I
G
D
V
R
D
L
E
R
L
N
Y
A
L
E
G
V
D
--
I
C
I
H
A
A
A
L
K
H
V
P
I
A
E
Y
N
P
L
E
C
I
K
T
N
I
M
G
A
S
N
V
I
N
A
C
L
-
K
N
---------
A
----
I
S
Q
V
I
A
L
S
T
D
K
A
A
------------------------
N
P
I
N
L
Y
G
A
T
K
L
C
S
D
--
K
L
F
V
S
A
N
N
FK
G
--------
S
S
Q
T
Q
F
S
V
V
R
Y
G
N
V
V
G
S
R
G
S
----
V
V
P
F
F
K
K
L
V
Q
N
K
-
A
S
E
I
P
I
-
T
D
I
R
M
T
R
F
W
I
T
L
D
E
G
V
S
F
V
L
K
S
L
K
R
M
-----
H
G
G
E
I
F
V
P
K
I
P
--
S
-
M
K
M
T
-
D
L
A
K
A
L
A
P
N
T
P
T
K
-------
I
I
G
I
R
P
G
E
K
L
H
E
V
M
I
P
K
D
E
S
H
L
A
L
E
F
E
D
F
F
----------------------------------------------------
25
PsiBlast_CBE
85.34
34%
-64
- C1 -
2GN4
4
PSEB_HELPY
B:
[18-294]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
L
D
N
Q
T
I
L
I
T
G
G
T
G
S
F
G
K
C
F
V
R
K
V
L
D
T
T
N
A
-
K
K
I
I
V
Y
S
R
D
E
L
K
Q
S
E
M
A
M
-
E
F
N
D
P
R
M
R
F
--------
F
I
G
D
V
R
D
L
E
R
L
N
Y
A
L
E
G
V
D
--
I
C
I
H
A
A
A
L
K
H
V
P
I
A
E
Y
N
P
L
E
C
I
K
T
N
I
M
G
A
S
N
V
I
N
A
C
L
-
K
N
---------
A
----
I
S
Q
V
I
A
L
S
T
D
K
A
A
------------------------
N
P
I
N
L
Y
G
A
T
K
L
C
S
D
--
K
L
F
V
S
A
N
N
FK
G
--------
S
S
Q
T
Q
F
S
V
V
R
Y
G
N
V
V
G
S
R
G
S
----
V
V
P
F
F
K
K
L
V
Q
N
K
-
A
S
E
I
P
I
-
T
D
I
R
M
T
R
F
W
I
T
L
D
E
G
V
S
F
V
L
K
S
L
K
R
M
-----
H
G
G
E
I
F
V
P
K
I
P
--
S
-
M
K
M
T
-
D
L
A
K
A
L
A
P
N
T
P
T
K
-------
I
I
G
I
R
P
G
E
K
L
H
E
V
M
I
P
K
D
E
S
H
L
A
L
E
F
E
D
F
F
----------------------------------------------------
22
PsiBlast_CBE
85.29
34%
-63
- C1 -
2GN9
4
PSEB_HELPY
B:
[18-294]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
L
D
N
Q
T
I
L
I
T
G
G
T
G
S
F
G
K
C
F
V
R
K
V
L
D
T
T
N
A
-
K
K
I
I
V
Y
S
R
D
E
L
K
Q
S
E
M
A
M
-
E
F
N
D
P
R
M
R
F
--------
F
I
G
D
V
R
D
L
E
R
L
N
Y
A
L
E
G
V
D
--
I
C
I
H
A
A
A
L
K
H
V
P
I
A
E
Y
N
P
L
E
C
I
K
T
N
I
M
G
A
S
N
V
I
N
A
C
L
-
K
N
---------
A
----
I
S
Q
V
I
A
L
S
T
D
K
A
A
------------------------
N
P
I
N
L
Y
G
A
T
K
L
C
S
D
--
K
L
F
V
S
A
N
N
FK
G
--------
S
S
Q
T
Q
F
S
V
V
R
Y
G
N
V
V
G
S
R
G
S
----
V
V
P
F
F
K
K
L
V
Q
N
K
-
A
S
E
I
P
I
-
T
D
I
R
M
T
R
F
W
I
T
L
D
E
G
V
S
F
V
L
K
S
L
K
R
M
-----
H
G
G
E
I
F
V
P
K
I
P
--
S
-
M
K
M
T
-
D
L
A
K
A
L
A
P
N
T
P
T
K
-------
I
I
G
I
R
P
G
E
K
L
H
E
V
M
I
P
K
D
E
S
H
L
A
L
E
F
E
D
F
F
----------------------------------------------------
31
Fugue
84.80
31%
-54
- C1 -
2GN4
3
PSEB_HELPY
A:
[16-344]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
N
M
L
D
N
Q
T
I
L
I
T
G
G
T
G
S
F
G
K
C
F
V
R
K
V
L
D
T
T
N
A
-
K
K
I
I
V
Y
S
R
D
E
---
L
K
Q
S
E
-
M
A
M
E
F
N
D
P
-----
R
M
R
F
F
I
G
D
V
R
D
L
E
R
L
N
Y
A
L
E
--
G
V
D
I
C
I
H
A
A
A
L
K
H
V
P
I
A
E
Y
N
P
L
E
C
I
K
T
N
I
M
G
A
S
N
V
I
N
A
C
L
-
K
N
---------
A
----
I
S
Q
V
I
A
L
S
T
D
K
A
A
------------------------
N
P
I
N
L
Y
G
A
T
K
L
C
S
D
--
K
L
F
V
S
A
N
N
FK
G
--------
S
S
Q
T
Q
F
S
V
V
R
Y
G
N
V
V
G
S
R
G
S
----
V
V
P
F
F
K
K
L
V
Q
-
N
K
A
S
E
I
P
I
-
T
D
I
R
M
T
R
F
W
I
T
L
D
E
G
V
S
F
V
L
K
S
L
K
R
M
-----
H
G
G
E
I
F
V
P
K
I
---
P
S
M
K
M
T
-
D
L
A
K
A
L
A
P
-------
N
T
P
T
K
I
I
G
I
R
P
G
E
K
L
H
E
V
M
I
P
K
D
E
S
H
L
A
L
E
F
E
D
F
F
I
--
I
Q
P
T
I
S
F
Q
T
P
K
D
Y
T
L
T
K
L
H
E
K
G
Q
K
V
A
P
D
F
E
Y
S
S
H
N
N
N
Q
W
L
E
P
D
D
L
L
K
L
L
2
PsiBlast_PDB
84.74
34%
-64
- C1 -
2GN6
2
PSEB_HELPY
A:
[17-294]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
M
L
D
N
Q
T
I
L
I
T
G
G
T
G
S
F
G
K
C
F
V
R
K
V
L
D
T
T
N
A
-
K
K
I
I
V
Y
S
R
D
E
L
K
Q
S
E
M
A
M
-
E
F
N
D
P
R
M
R
F
--------
F
I
G
D
V
R
D
L
E
R
L
N
Y
A
L
E
G
V
D
--
I
C
I
H
A
A
A
L
K
H
V
P
I
A
E
Y
N
P
L
E
C
I
K
T
N
I
M
G
A
S
N
V
I
N
A
C
L
-
K
N
---------
A
----
I
S
Q
V
I
A
L
S
T
D
K
A
A
------------------------
N
P
I
N
L
Y
G
A
T
K
L
C
S
D
--
K
L
F
V
S
A
N
N
FK
G
--------
S
S
Q
T
Q
F
S
V
V
R
Y
G
N
V
V
G
S
R
G
S
----
V
V
P
F
F
K
K
L
V
Q
N
K
-
A
S
E
I
P
I
-
T
D
I
R
M
T
R
F
W
I
T
L
D
E
G
V
S
F
V
L
K
S
L
K
R
M
-----
H
G
G
E
I
F
V
P
K
I
P
--
S
-
M
K
M
T
-
D
L
A
K
A
L
A
P
N
T
P
T
K
-------
I
I
G
I
R
P
G
E
K
L
H
E
V
M
I
P
K
D
E
S
H
L
A
L
E
F
E
D
F
F
----------------------------------------------------
3
PsiBlast_PDB
84.54
34%
-62
- C1 -
2GN8
3
PSEB_HELPY
A:
[18-294]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
L
D
N
Q
T
I
L
I
T
G
G
T
G
S
F
G
K
C
F
V
R
K
V
L
D
T
T
N
A
-
K
K
I
I
V
Y
S
R
D
E
L
K
Q
S
E
M
A
M
-
E
F
N
D
P
R
M
R
F
--------
F
I
G
D
V
R
D
L
E
R
L
N
Y
A
L
E
G
V
D
--
I
C
I
H
A
A
A
L
K
H
V
P
I
A
E
Y
N
P
L
E
C
I
K
T
N
I
M
G
A
S
N
V
I
N
A
C
L
-
K
N
---------
A
----
I
S
Q
V
I
A
L
S
T
D
K
A
A
------------------------
N
P
I
N
L
Y
G
A
T
K
L
C
S
D
--
K
L
F
V
S
A
N
N
FK
G
--------
S
S
Q
T
Q
F
S
V
V
R
Y
G
N
V
V
G
S
R
G
S
----
V
V
P
F
F
K
K
L
V
Q
N
K
-
A
S
E
I
P
I
-
T
D
I
R
M
T
R
F
W
I
T
L
D
E
G
V
S
F
V
L
K
S
L
K
R
M
-----
H
G
G
E
I
F
V
P
K
I
P
--
S
-
M
K
M
T
-
D
L
A
K
A
L
A
P
N
T
P
T
K
-------
I
I
G
I
R
P
G
E
K
L
H
E
V
M
I
P
K
D
E
S
H
L
A
L
E
F
E
D
F
F
----------------------------------------------------
21
PsiBlast_CBE
84.41
34%
-63
- C1 -
2GNA
3
PSEB_HELPY
B:
[18-294]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
L
D
N
Q
T
I
L
I
T
G
G
T
G
S
F
G
K
C
F
V
R
K
V
L
D
T
T
N
A
-
K
K
I
I
V
Y
S
R
D
E
L
K
Q
S
E
M
A
M
-
E
F
N
D
P
R
M
R
F
--------
F
I
G
D
V
R
D
L
E
R
L
N
Y
A
L
E
G
V
D
--
I
C
I
H
A
A
A
L
K
H
V
P
I
A
E
Y
N
P
L
E
C
I
K
T
N
I
M
G
A
S
N
V
I
N
A
C
L
-
K
N
---------
A
----
I
S
Q
V
I
A
L
S
T
D
K
A
A
------------------------
N
P
I
N
L
Y
G
A
T
K
L
C
S
D
--
K
L
F
V
S
A
N
N
FK
G
--------
S
S
Q
T
Q
F
S
V
V
R
Y
G
N
V
V
G
S
R
G
S
----
V
V
P
F
F
K
K
L
V
Q
N
K
-
A
S
E
I
P
I
-
T
D
I
R
M
T
R
F
W
I
T
L
D
E
G
V
S
F
V
L
K
S
L
K
R
M
-----
H
G
G
E
I
F
V
P
K
I
P
--
S
-
M
K
M
T
-
D
L
A
K
A
L
A
P
N
T
P
T
K
-------
I
I
G
I
R
P
G
E
K
L
H
E
V
M
I
P
K
D
E
S
H
L
A
L
E
F
E
D
F
F
----------------------------------------------------
56
HHSearch
78.63
20%
-55
- C1 -
1KEW
5
RMLB_SALTY
A:
[1-341]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
K
I
L
I
T
G
G
A
G
F
I
G
S
A
V
V
R
H
I
I
K
N
T
-
Q
-
D
T
V
V
N
I
D
K
L
T
---
Y
A
G
N
L
E
S
L
S
D
I
S
E
----
S
N
R
Y
N
F
E
H
A
D
I
C
D
S
A
E
I
T
R
I
F
E
Q
Y
Q
P
D
A
V
M
H
L
A
A
E
S
H
V
D
R
S
I
T
G
P
A
A
F
I
E
T
N
I
V
G
T
Y
A
L
L
E
V
A
R
-
K
Y
W
S
A
LG
E
D
K
K
N
----
N
F
R
F
H
H
I
S
T
D
E
V
Y
GDLPHPDEVENS
V
T
L
P
L
F
T
ETT
A
Y
A
P
S
S
P
Y
S
A
S
K
A
S
S
D
--
H
L
V
R
A
W
R
R
--
T
---------
Y
G
L
P
T
I
V
T
N
C
S
N
N
Y
G
P
Y
H
F
PEK-
L
I
P
L
V
I
L
N
A
L
-
E
-
G
K
P
L
P
I
Y
G
K
G
D
Q
I
R
D
W
L
Y
V
E
D
H
A
R
A
L
H
M
V
V
T
E
G
-----
K
A
G
E
T
Y
N
I
G
G
H
--
N
E
K
K
N
L
-
D
V
V
F
T
I
C
D
L
L
D
E
I
V
P
K
A
T
S
Y
R
E
Q
I
T
Y
V
A
--
D
--
R
P
-
G
H
D
R
R
Y
A
I
D
A
G
K
I
S
R
--
E
L
G
W
K
-
P
L
E
T
F
E
S
G
I
R
K
T
V
E
W
Y
L
A
N
T
Q
W
V
--------------------
58
HHSearch
78.53
20%
-56
- C1 -
1RKX
1
?
A:
[4-339]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
S
F
W
Q
G
K
R
V
F
V
T
G
H
T
G
F
K
G
G
W
L
S
L
W
L
Q
T
M
G
---
A
T
V
K
G
Y
S
L
T
A
---
P
T
V
P
S
-
L
F
E
T
A
R
V
----
A
D
G
M
Q
S
E
I
G
D
I
R
D
Q
N
K
L
L
E
S
I
R
E
F
Q
P
E
I
V
F
H
M
A
A
Q
P
L
V
R
L
S
Y
S
E
P
V
E
T
Y
S
T
N
V
M
G
T
V
Y
L
L
E
A
I
R
-
H
V
G--------
G
----
V
K
A
V
V
N
I
T
S
D
K
C
Y
DNKEWI
W
G
Y
R
EN
E
A
M
---------
G
G
Y
D
P
Y
S
N
S
K
G
C
A
E
--
L
V
T
S
S
Y
R
N
--
S
FFNPANYG
Q
H
G
T
A
V
A
T
V
R
A
G
N
V
I
G
G
G
D
W
ALDR
I
V
P
D
I
L
R
A
F
E
-
Q
-
S
Q
P
V
I
I
-
R
N
P
H
A
I
R
P
W
Q
H
V
L
E
P
L
S
G
Y
L
L
L
A
Q
K
L
Y
T
DGA
E
Y
A
E
G
W
N
F
G
P
N
DA
D
A
T
P
V
K
-
N
I
V
E
Q
M
V
K
Y
W
G
E
G
A
---
S
W
Q
L
----------------
E
A
H
Y
L
K
L
D
C
S
K
A
K
M
--
Q
L
G
W
H
-
P
R
W
N
L
N
T
T
L
E
Y
I
V
G
W
H
K
N
W
L
S
G
---------------------
33
Fugue
77.72
26%
-56
- C1 -
4TQG
1
?
A:
[1-319]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
Q
I
N
D
K
T
I
M
I
F
G
G
S
G
S
L
G
N
R
L
I
E
T
Y
I
N
---
N
-
N
I
I
V
N
Y
S
R
D
E
---
S
K
H
W
S
-
M
E
L
K
Y
K
S
D
-----
K
L
K
N
I
I
G
D
I
R
D
F
E
K
V
Q
Q
S
I
M
R
I
N
P
D
I
I
I
I
A
A
A
L
K
H
I
D
R
C
E
Y
E
I
N
E
C
L
D
T
N
I
K
G
L
Q
N
V
L
K
V
T
E
I
N
R
---------
S
NLSN
L
K
A
V
C
F
V
S
T
D
K
A
C
------------------------
S
P
V
N
S
Y
G
M
S
K
A
I
C
E
--
T
L
V
V
E
K
S
K
--
Y
--------
I
K
D
I
K
Y
V
C
V
R
Y
G
N
V
L
N
------------------------
F
T
L
-
T
H
T
S
M
T
R
F
I
M
T
L
D
D
S
V
K
L
I
E
Y
A
I
I
N
G
-----
N
S
G
E
I
V
I
P
K
L
N
-----------
S
M
Y
I
K
D
M
I
E
L
F
A
D
K
Y
P
I
V
I
T
G
L
R
S
G
E
R
M
Y
E
S
L
I
N
D
T
Q
S
M
K
T
V
P
K
G
D
Y
Y
H
I
L
P
T
Y
D
P
T
I
V
T
E
E
F
Y
E
Y
S
S
K
Q
N
I
L
S
K
Q
E
L
E
N
Y
L
N
Q
----------------
51
HHSearch
77.65
22%
-60
- C1 -
2HUN
1
?
A:
[3-318]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
M
K
L
L
V
T
G
G
M
G
F
I
G
S
N
F
I
R
Y
I
L
E
K
H
-
P
D
W
E
V
I
N
I
D
K
L
G
---
Y
G
S
N
P
A
N
L
K
D
L
E
D
----
D
P
R
Y
T
F
V
K
G
D
V
A
D
Y
E
L
V
K
E
L
V
R
--
K
V
D
G
V
V
H
L
A
A
E
S
H
V
D
R
S
I
S
S
P
E
I
F
L
H
S
N
V
I
G
T
Y
T
L
L
E
S
I
R
-
R
E
N--------
P
----
E
V
R
F
V
H
V
S
T
D
E
V
Y
GDIL
K
G
S
F
T
EN
D
R
L
----------
M
P
S
S
P
Y
S
A
T
K
A
A
S
D
--
M
L
V
L
G
W
T
R
--
T
---------
Y
N
L
N
A
S
I
T
R
C
T
N
N
Y
G
P
Y
Q
F
PEK-
L
I
P
K
T
I
I
R
A
S
-
L
-
G
L
K
I
P
I
Y
G
T
---
V
R
D
W
L
Y
V
E
D
H
V
R
A
I
E
L
V
L
L
K
G
-----
E
S
R
E
I
Y
N
I
S
A
G
--
E
E
K
T
N
L
-
E
V
V
K
I
I
L
R
L
M
G
K
G
E
E
L
I
E
L
--
V
E
D
R
P
G
----------
H
D
L
R
Y
S
L
D
S
W
K
I
T
R
--
D
L
K
W
R
-
P
K
Y
T
F
D
E
G
I
K
K
T
I
D
W
Y
L
K
N
E
W
W
W
--------------------