@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : SA0171: (2016-03-12 )
MSNGAVFFVIFLKQATCNTYFKEVKIYHLGEMDMKIVALFPEAVEGQENQLLNTKKAIGLKTFLEERGHEFIILADNGEDLDKHLPDMDVIISAPFYPAYMTRERIEKAPNLKLAITAGVGSDHVDLAAASEHNIGVVEVTGSNTVSVAEHAVMDLLILLRNYEEGHRQSVEGEWNLSQVGNHAHELQHKTIGIFGFGRIGQLVAERLAPFNVTLQHYDPINQQDHKLSKFVSFDELVSSSDAITIHAPLTPETDNLFDKDVLSRMKKHSYLVNTARGKIVNRDALVEALASEHLQGYAGDVWYPQPAPADHPWRTMPRNAMTVHYSGMTLEAQKRIEDGVKDILERFFNHEPFQDKDIIVASGRIASKSYTAK
Atome Classification :
(29 SA)
.........10........20........30...---....-.40....---....50.-.....-.-.60........70.....------.---..80-.........90........100.......110........120.......130--..--.....140.......150.......160.......170..-.....180........190.......200.......210..-.----....-----220---..-.----...-..---.-230-.------......240.......250.......260.......270.......280.......290.......300.......310.......-----320---.........330.....-..340.......350-..-.....360.....---..370..
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MSNG
A
V
F
F
V
I
F
L
KQAT
C
N
T
Y
F
K
E
V
K
I
Y
HLGEM
D
M
---
K
I
V
A
-LF
P
E
AVE---GQENQLL-
N
T
K
K
A-I-
G
L
K
T
F
L
E
ERG
H
E
F
I
I
L
AD------N---G
E
D
--
L
D
K
HLPDM
D
V
I
ISAPF
Y
P
A
Y
M
T
R
E
R
I
E
KAPN-
L
K
L
A
I
T
AGVGSDH
V
D
L
A
AASE--H
N
--
I
G
V
V
E
VTGSN
T
V
S
V
A
E
H
A
V
M
D
L
L
I
L
L
R
N
Y
E
EGHRQSVEGE-W
N
L
S
Q
V-G
N
H
A
H
E
L
Q
H
K
T
I
G
I
F
G
F
G
R
I
G
Q
L
V
A
E
RLAP
F
N
V
T
-
L
----
Q
HYD-----P-----IN-Q----
Q
D
H
-
K
L
---
S
-
K
F
V
-
S
------
F
D
E
L
VSSS
D
A
I
T
I
HAPLTPETDNLF
D
K
D
V
L
S
R
M
K
K
H
S
Y
L
V
NTARGKIV
N
R
D
A
L
V
E
A
L
A
S
E
H
L
Q
GYAGDVWYPQPAPADHPWRTMPR-----
N
-----
A
M
T
V
H
YSGM
T
L
E
A
Q
K
R
I
-
E
D
G
V
K
D
I
L
E
R
F
FNHE-PF-QDK
D
I
I
V
AS
G
R
I
A---SKSYTAK
33
PsiBlast_CBE
94.22
47%
-100
- C2 -
3N7U
4
FDH_ARATH
B:
[4-349]
-------------------------------------
K
I
V
G
-
V
F
Y
K
A
N
E
YAT
K
N
P
N
F
L
G
-
C
V
E
N
A
-
L
-
G
I
R
D
W
L
E
S
Q
G
H
Q
Y
I
V
T
D
D
------
K
E--
G
P
D
CE
L
E
K
H
I
P
D
L
H
V
L
I
S
T
P
F
H
P
A
Y
V
T
A
E
R
I
K
K
A
K
N
-
L
K
L
L
L
T
A
G
I
G
S
D
H
I
D
L
Q
A
A
A
A
--
A
G
--
L
T
V
A
E
V
T
G
S
N
V
V
S
V
A
E
D
E
L
M
R
I
L
I
L
M
R
N
F
V
P
G
Y
N
Q
V
V
K
G
E
-
W
N
V
A
G
I
-
A
Y
R
A
Y
D
L
E
G
K
T
I
G
T
V
G
A
G
R
I
G
K
L
L
L
Q
R
L
K
P
F
G
C
N
-
L
----
L
Y
H
D
-----
R
-----
L
Q
-
M
APEL
E
K
E
-
T
G
---
A
-
K
F
V
E
D
------
L
N
E
M
L
P
K
C
D
V
I
V
I
N
M
P
L
T
E
K
T
R
G
M
F
N
K
E
L
I
G
K
L
K
K
G
V
L
I
V
N
N
A
R
G
A
I
M
E
R
Q
A
V
V
D
A
V
E
S
G
H
I
G
G
Y
S
G
D
V
W
D
P
Q
P
A
P
K
D
H
P
W
R
Y
M
P
N
-----
Q
-----
A
M
T
P
H
T
S
G
T
T
I
D
A
Q
L
R
Y
-
A
A
G
T
K
D
M
L
E
R
Y
F
K
G
E
-
D
F
-
P
T
E
N
Y
I
V
K
D
G
E
L
A
---
P
Q
-----
4
PsiBlast_PDB
94.22
47%
-104
- C2 -
3N7U
3
FDH_ARATH
A:
[4-349]
-------------------------------------
K
I
V
G
-
V
F
Y
K
A
N
E
YAT
K
N
P
N
F
L
G
-
C
V
E
N
A
-
L
-
G
I
R
D
W
L
E
S
Q
G
H
Q
Y
I
V
T
D
D
------
K
E--
G
P
D
C
E
L
E
K
H
I
P
D
L
H
V
L
I
S
T
P
F
H
P
A
Y
V
T
A
E
R
I
K
K
A
K
N
-
L
K
L
L
L
T
A
G
I
G
S
D
H
I
D
L
Q
A
A
A
A
--
A
G
--
L
T
V
A
E
V
T
G
S
N
V
V
S
V
A
E
D
E
L
M
R
I
L
I
L
M
R
N
F
V
P
G
Y
N
Q
V
V
K
G
E
-
W
N
V
A
G
I
-
A
Y
R
A
Y
D
L
E
G
K
T
I
G
T
V
G
A
G
R
I
G
K
L
L
L
Q
R
L
K
P
F
G
C
N
-
L
----
L
Y
H
D
-----
R
-----
L
Q
-
M
A
P
E
L
E
K
E
-
T
G
---
A
-
K
F
V
E
D
------
L
N
E
M
L
P
K
C
D
V
I
V
I
N
M
P
L
T
E
K
T
R
G
M
F
N
K
E
L
I
G
K
L
K
K
G
V
L
I
V
N
N
A
R
G
A
I
M
E
R
Q
A
V
V
D
A
V
E
S
G
H
I
G
G
Y
S
G
D
V
W
D
P
Q
P
A
P
K
D
H
P
W
R
Y
M
P
N
-----
Q
-----
A
M
T
P
H
T
S
G
T
T
I
D
A
Q
L
R
Y
-
A
A
G
T
K
D
M
L
E
R
Y
F
K
G
E
-
D
F
-
P
T
E
N
Y
I
V
K
D
G
E
L
A
---
P
Q
-----
5
PsiBlast_PDB
94.10
47%
-110
* C2 *
3JTM
16
FDH_ARATH
A:
[4-349]
-------------------------------------
K
I
V
G
-
V
F
Y
K
A
N
E
Y
A
T
K
N
P
N
F
L
G
-
C
V
E
N
A
-
L
-
G
I
R
D
W
L
E
S
Q
G
H
Q
Y
I
V
T
D
D
------
K
E--
G
P
D
C
E
L
E
K
H
I
P
D
L
H
V
L
I
S
T
P
F
H
P
A
Y
V
T
A
E
R
I
K
K
A
K
N
-
L
K
L
L
L
T
A
G
I
G
S
D
H
I
D
L
Q
A
A
A
A
--
A
G
--
L
T
V
A
E
V
T
G
S
N
V
V
S
V
A
E
D
E
L
M
R
I
L
I
L
M
R
N
F
V
P
G
Y
N
Q
V
V
K
G
E
-
W
N
V
A
G
I
-
A
Y
R
A
Y
D
L
E
G
K
T
I
G
T
V
G
A
G
R
I
G
K
L
L
L
Q
R
L
K
P
F
G
C
N
-
L
----
L
Y
H
D
-----
R
-----
L
Q
-
M
A
P
E
L
E
K
E
-
T
G
---
A
-
K
F
V
E
D
------
L
N
E
M
L
P
K
C
D
V
I
V
I
N
M
P
L
T
E
K
T
R
G
M
F
N
K
E
L
I
G
K
L
K
K
G
V
L
I
V
N
N
A
R
G
A
I
M
E
R
Q
A
V
V
D
A
V
E
S
G
H
I
G
G
Y
S
G
D
V
W
D
P
Q
P
A
P
K
D
H
P
W
R
Y
M
P
N
-----
Q
-----
A
M
T
P
H
T
S
G
T
T
I
D
A
Q
L
R
Y
-
A
A
G
T
K
D
M
L
E
R
Y
F
K
G
E
-
D
F
-
P
T
E
N
Y
I
V
K
D
G
E
L
A
---
P
Q
-----
24
PsiBlast_CBE
94.00
47%
-103
- C2 -
3N7U
30
FDH_ARATH
K:
[4-349]
-------------------------------------
K
I
V
G
-
V
F
Y
K
A
N
E
YAT
K
N
P
N
F
L
G
-
C
V
E
N
A
-
L
-
G
I
R
D
W
L
E
S
Q
G
H
Q
Y
I
V
T
D
D
------
K
E--
G
P
D
CE
L
E
K
H
I
P
D
L
H
V
L
I
S
T
P
F
H
P
A
Y
V
T
A
E
R
I
K
K
A
K
N
-
L
K
L
L
L
T
A
G
I
G
S
D
H
I
D
L
Q
A
A
A
A
--
A
G
--
L
T
V
A
E
V
T
G
S
N
V
V
S
V
A
E
D
E
L
M
R
I
L
I
L
M
R
N
F
V
P
G
Y
N
Q
V
V
K
G
E
-
W
N
V
A
G
I
-
A
Y
R
A
Y
D
L
E
G
K
T
I
G
T
V
G
A
G
R
I
G
K
L
L
L
Q
R
L
K
P
F
G
C
N
-
L
----
L
Y
H
D
-----
R
-----
L
Q
-
M
APEL
E
K
E
-
T
G
---
A
-
K
F
V
E
D
------
L
N
E
M
L
P
K
C
D
V
I
V
I
N
M
P
L
T
E
K
T
R
G
M
F
N
K
E
L
I
G
K
L
K
K
G
V
L
I
V
N
N
A
R
G
A
I
M
E
R
Q
A
V
V
D
A
V
E
S
G
H
I
G
G
Y
S
G
D
V
W
D
P
Q
P
A
P
K
D
H
P
W
R
Y
M
P
N
-----
Q
-----
A
M
T
P
H
T
S
G
T
T
I
D
A
Q
L
R
Y
-
A
A
G
T
K
D
M
L
E
R
Y
F
K
G
E
-
D
F
-
P
T
E
N
Y
I
V
K
D
G
E
L
A
---
P
Q
-----
30
PsiBlast_CBE
93.27
47%
-104
- C2 -
3N7U
1
FDH_ARATH
E:
[4-349]
-------------------------------------
K
I
V
G
-
V
F
Y
K
A
N
E
YAT
K
N
P
N
F
L
G
-
C
V
E
N
A
-
L
-
G
I
R
D
W
L
E
S
Q
G
H
Q
Y
I
V
T
D
D
------
K
E--
G
P
D
CE
L
E
K
H
I
P
D
L
H
V
L
I
S
T
P
F
H
P
A
Y
V
T
A
E
R
I
K
K
A
K
N
-
L
K
L
L
L
T
A
G
I
G
S
D
H
I
D
L
Q
A
A
A
A
--
A
G
--
L
T
V
A
E
V
T
G
S
N
V
V
S
V
A
E
D
E
L
M
R
I
L
I
L
M
R
N
F
V
P
G
Y
N
Q
V
V
K
G
E
-
W
N
V
A
G
I
-
A
Y
R
A
Y
D
L
E
G
K
T
I
G
T
V
G
A
G
R
I
G
K
L
L
L
Q
R
L
K
P
F
G
C
N
-
L
----
L
Y
H
D
-----
R
-----
L
Q
-
M
APEL
E
K
E
-
T
G
---
A
-
K
F
V
E
D
------
L
N
E
M
L
P
K
C
D
V
I
V
I
N
M
P
L
T
E
K
T
R
G
M
F
N
K
E
L
I
G
K
L
K
K
G
V
L
I
V
N
N
A
R
G
A
I
M
E
R
Q
A
V
V
D
A
V
E
S
G
H
I
G
G
Y
S
G
D
V
W
D
P
Q
P
A
P
K
D
H
P
W
R
Y
M
P
N
-----
Q
-----
A
M
T
P
H
T
S
G
T
T
I
D
A
Q
L
R
Y
-
A
A
G
T
K
D
M
L
E
R
Y
F
K
G
E
-
D
F
-
P
T
E
N
Y
I
V
K
D
G
E
L
A
---
P
Q
-----
34
PsiBlast_CBE
93.20
47%
-109
- C2 -
3NAQ
4
FDH_ARATH
B:
[10-355]
-------------------------------------
K
I
V
G
-
V
F
Y
K
A
N
E
YAT
K
N
P
N
F
L
G
-
C
V
E
N
A
-
L
-
G
I
R
D
W
L
E
S
Q
G
H
Q
Y
I
V
T
D
D
------
K
E--
G
P
D
CE
L
E
K
H
I
P
D
L
H
V
L
I
S
T
P
F
H
P
A
Y
V
T
A
E
R
I
K
K
A
K
N
-
L
K
L
L
L
T
A
G
I
G
S
D
H
I
D
L
Q
A
A
A
A
--
A
G
--
L
T
V
A
E
V
T
G
S
N
V
V
S
V
A
E
D
E
L
M
R
I
L
I
L
M
R
N
F
V
P
G
Y
N
Q
V
V
K
G
E
-
W
N
V
A
G
I
-
A
Y
R
A
Y
D
L
E
G
K
T
I
G
T
V
G
A
G
R
I
G
K
L
L
L
Q
R
L
K
P
F
G
C
N
-
L
----
L
Y
H
D
-----
R
-----
L
Q
-
M
APEL
E
K
E
-
T
G
---
A
-
K
F
V
E
D
------
L
N
E
M
L
P
K
C
D
V
I
V
I
N
M
P
L
T
E
K
T
R
G
M
F
N
K
E
L
I
G
K
L
K
K
G
V
L
I
V
N
N
A
R
G
A
I
M
E
R
Q
A
V
V
D
A
V
E
S
G
H
I
G
G
Y
S
G
D
V
W
D
P
Q
P
A
P
K
D
H
P
W
R
Y
M
P
N
-----
Q
-----
A
M
T
P
H
T
S
G
T
T
I
D
A
Q
L
R
Y
-
A
A
G
T
K
D
M
L
E
R
Y
F
K
G
E
-
D
F
-
P
T
E
N
Y
I
V
K
D
G
E
L
A
---
P
Q
-----
6
PsiBlast_PDB
93.07
47%
-109
- C2 -
3NAQ
4
FDH_ARATH
A:
[10-355]
-------------------------------------
K
I
V
G
-
V
F
Y
K
A
N
E
Y
A
T
K
N
P
N
F
L
G
-
C
V
E
N
A
-
L
-
G
I
R
D
W
L
E
S
Q
G
H
Q
Y
I
V
T
D
D
------
K
E--
G
P
D
C
E
L
E
K
H
I
P
D
L
H
V
L
I
S
T
P
F
H
P
A
Y
V
T
A
E
R
I
K
K
A
K
N
-
L
K
L
L
L
T
A
G
I
G
S
D
H
I
D
L
Q
A
A
A
A
--
A
G
--
L
T
V
A
E
V
T
G
S
N
V
V
S
V
A
E
D
E
L
M
R
I
L
I
L
M
R
N
F
V
P
G
Y
N
Q
V
V
K
G
E
-
W
N
V
A
G
I
-
A
Y
R
A
Y
D
L
E
G
K
T
I
G
T
V
G
A
G
R
I
G
K
L
L
L
Q
R
L
K
P
F
G
C
N
-
L
----
L
Y
H
D
-----
R
-----
L
Q
-
M
A
P
E
L
E
K
E
-
T
G
---
A
-
K
F
V
E
D
------
L
N
E
M
L
P
K
C
D
V
I
V
I
N
M
P
L
T
E
K
T
R
G
M
F
N
K
E
L
I
G
K
L
K
K
G
V
L
I
V
N
N
A
R
G
A
I
M
E
R
Q
A
V
V
D
A
V
E
S
G
H
I
G
G
Y
S
G
D
V
W
D
P
Q
P
A
P
K
D
H
P
W
R
Y
M
P
N
-----
Q
-----
A
M
T
P
H
T
S
G
T
T
I
D
A
Q
L
R
Y
-
A
A
G
T
K
D
M
L
E
R
Y
F
K
G
E
-
D
F
-
P
T
E
N
Y
I
V
K
D
G
E
L
A
---
P
Q
-----
32
PsiBlast_CBE
93.05
47%
-100
- C2 -
3N7U
4
FDH_ARATH
C:
[4-349]
-------------------------------------
K
I
V
G
-
V
F
Y
K
A
N
E
YAT
K
N
P
N
F
L
G
-
C
V
E
N
A
-
L
-
G
I
R
D
W
L
E
S
Q
G
H
Q
Y
I
V
T
D
D
------
K
E--
G
P
D
CE
L
E
K
H
I
P
D
L
H
V
L
I
S
T
P
F
H
P
A
Y
V
T
A
E
R
I
K
K
A
K
N
-
L
K
L
L
L
T
A
G
I
G
S
D
H
I
D
L
Q
A
A
A
A
--
A
G
--
L
T
V
A
E
V
T
G
S
N
V
V
S
V
A
E
D
E
L
M
R
I
L
I
L
M
R
N
F
V
P
G
Y
N
Q
V
V
K
G
E
-
W
N
V
A
G
I
-
A
Y
R
A
Y
D
L
E
G
K
T
I
G
T
V
G
A
G
R
I
G
K
L
L
L
Q
R
L
K
P
F
G
C
N
-
L
----
L
Y
H
D
-----
R
-----
L
Q
-
M
APEL
E
K
E
-
T
G
---
A
-
K
F
V
E
D
------
L
N
E
M
L
P
K
C
D
V
I
V
I
N
M
P
L
T
E
K
T
R
G
M
F
N
K
E
L
I
G
K
L
K
K
G
V
L
I
V
N
N
A
R
G
A
I
M
E
R
Q
A
V
V
D
A
V
E
S
G
H
I
G
G
Y
S
G
D
V
W
D
P
Q
P
A
P
K
D
H
P
W
R
Y
M
P
N
-----
Q
-----
A
M
T
P
H
T
S
G
T
T
I
D
A
Q
L
R
Y
-
A
A
G
T
K
D
M
L
E
R
Y
F
K
G
E
-
D
F
-
P
T
E
N
Y
I
V
K
D
G
E
L
A
---
P
Q
-----
31
PsiBlast_CBE
93.00
47%
-102
- C2 -
3N7U
2
FDH_ARATH
D:
[4-349]
-------------------------------------
K
I
V
G
-
V
F
Y
K
A
N
E
YAT
K
N
P
N
F
L
G
-
C
V
E
N
A
-
L
-
G
I
R
D
W
L
E
S
Q
G
H
Q
Y
I
V
T
D
D
------
K
E--
G
P
D
CE
L
E
K
H
I
P
D
L
H
V
L
I
S
T
P
F
H
P
A
Y
V
T
A
E
R
I
K
K
A
K
N
-
L
K
L
L
L
T
A
G
I
G
S
D
H
I
D
L
Q
A
A
A
A
--
A
G
--
L
T
V
A
E
V
T
G
S
N
V
V
S
V
A
E
D
E
L
M
R
I
L
I
L
M
R
N
F
V
P
G
Y
N
Q
V
V
K
G
E
-
W
N
V
A
G
I
-
A
Y
R
A
Y
D
L
E
G
K
T
I
G
T
V
G
A
G
R
I
G
K
L
L
L
Q
R
L
K
P
F
G
C
N
-
L
----
L
Y
H
D
-----
R
-----
L
Q
-
M
APEL
E
K
E
-
T
G
---
A
-
K
F
V
E
D
------
L
N
E
M
L
P
K
C
D
V
I
V
I
N
M
P
L
T
E
K
T
R
G
M
F
N
K
E
L
I
G
K
L
K
K
G
V
L
I
V
N
N
A
R
G
A
I
M
E
R
Q
A
V
V
D
A
V
E
S
G
H
I
G
G
Y
S
G
D
V
W
D
P
Q
P
A
P
K
D
H
P
W
R
Y
M
P
N
-----
Q
-----
A
M
T
P
H
T
S
G
T
T
I
D
A
Q
L
R
Y
-
A
A
G
T
K
D
M
L
E
R
Y
F
K
G
E
-
D
F
-
P
T
E
N
Y
I
V
K
D
G
E
L
A
---
P
Q
-----
80
HHSearch
87.72
46%
-105
- C2 -
3JTM
16
FDH_ARATH
A:
[2-350]
--------------------------------
S
K
---
K
I
V
G
V
F
Y
K
A
N
E
Y
A
--
T
K
N
P
N
F
L
G
C
V
E
N
A
-
L
-
G
I
R
D
W
L
E
S
Q
G
H
Q
Y
I
V
T
D
D
KEG---
P
---
D
C
E
--
L
E
K
H
I
P
D
L
H
V
L
I
S
T
P
F
H
P
A
Y
V
T
A
E
R
I
K
K
A
K
N
-
L
K
L
L
L
T
A
G
I
G
S
D
H
I
D
L
Q
A
A
A
A
--
A
G
--
L
T
V
A
E
V
T
G
S
N
V
V
S
V
A
E
D
E
L
M
R
I
L
I
L
M
R
N
F
V
P
G
Y
N
Q
V
V
K
G
E
-
W
N
V
A
G
I
-
A
Y
R
A
Y
D
L
E
G
K
T
I
G
T
V
G
A
G
R
I
G
K
L
L
L
Q
R
L
K
P
F
G
C
N
------
L
L
Y
H
-----
D
-----
R
L
-
Q
----
M
A
P
-
E
L
---
E
-
K
E
T
-
G
A
K
F
V
ED
L
N
E
M
L
P
K
C
D
V
I
V
I
N
M
P
L
T
E
K
T
R
G
M
F
N
K
E
L
I
G
K
L
K
K
G
V
L
I
V
N
N
A
R
G
A
I
M
E
R
Q
A
V
V
D
A
V
E
S
G
H
I
G
G
Y
S
G
D
V
W
D
P
Q
P
A
P
K
D
H
P
W
R
Y
M
P
N
-----
Q
-----
A
M
T
P
H
T
S
G
T
T
I
D
A
Q
L
R
Y
-
A
A
G
T
K
D
M
L
E
R
Y
F
K
G
E
-
D
F
-
P
T
E
N
Y
I
V
K
D
G
E
L
A
---
P
Q
Y
----
101
Fugue
87.63
42%
-97
- C2 -
2NAC
1
FDH_PSESR
A:
[1-374]
-----
A
K
V
L
C
V
L
Y
D
D
P
V
D
G
Y
P
K
T
Y
A
R
D
D
L
P
K
I
D
H
YPG
G
Q
T
L
-
P
T
P
K
A
I
D
---
F
T
P
G
Q
L
L
-
G
S
V
S
G
-
E
L
G
L
R
K
Y
L
E
S
N
G
H
T
L
V
V
T
S
D
KDGPDS
V
---
F
E
R
--
E
L
V
D
A
D
---
V
V
I
S
Q
P
F
W
P
A
Y
L
T
P
E
R
I
A
K
A
K
N
L-
K
L
A
L
T
A
G
I
G
S
D
H
V
D
L
Q
S
A
I
D
--
R
N
--
V
T
V
A
E
V
T
Y
C
N
S
I
S
V
A
E
H
V
V
M
M
I
L
S
L
V
R
N
Y
L
P
S
H
E
W
A
R
-
K
G
G
W
N
I
A
D
C
-
V
S
H
A
Y
D
L
E
A
M
H
V
G
T
V
A
A
G
R
I
G
L
A
V
L
R
R
L
A
P
F
D
V
H
-
L
----
H
Y
T
D
-----
R
HRLP
E
S
V
-
E
----
K
E
L
-
N
L
---
T
-
W
H
A
-
T
------
R
E
D
M
Y
P
V
C
D
V
V
T
L
N
C
P
L
H
P
E
T
E
H
M
I
N
D
E
T
L
K
L
F
K
R
G
A
Y
I
V
N
T
A
R
G
K
L
C
D
R
D
A
V
A
R
A
L
E
S
G
R
L
A
G
Y
A
G
D
V
W
F
P
Q
P
A
P
K
D
H
P
W
R
T
M
P
Y
-----
N
-----
G
M
T
P
H
I
S
G
T
T
L
T
A
Q
A
R
Y
-
A
A
G
T
R
E
I
L
E
C
F
F
E
G
R
-
P
I
-
R
D
E
Y
L
I
V
Q
G
G
A
L
A
----------
81
HHSearch
86.25
45%
-103
- C2 -
2J6I
1
FDH_CANBO
A:
[4-353]
--------------------------------------
V
L
V
-
L
Y
D
A
G
K
H
A
--
A
D
E
E
K
L
Y
G
C
T
E
N
K
-
L
-
G
I
A
N
W
L
K
D
Q
G
H
E
L
I
T
T
S
D
KEG---
G
---
N
S
V
--
L
D
Q
H
I
P
D
A
D
I
I
I
T
T
P
F
H
P
A
Y
I
T
K
E
R
I
D
K
A
K
K
-
L
K
L
V
V
V
A
G
V
G
S
D
H
I
D
L
D
Y
I
N
Q
--
T
G
KK
I
S
V
L
E
V
T
G
S
N
V
V
S
V
A
E
H
V
V
M
T
M
L
V
L
V
R
N
F
V
P
A
H
E
Q
I
I
N
H
D
-
W
E
V
A
A
I
-
A
K
D
A
Y
D
I
E
G
K
T
I
A
T
I
G
A
G
R
I
G
Y
R
V
L
E
R
L
V
P
F
N
P
K
-
E
----
L
L
Y
Y
-----
D
-----
Y
Q
-
A
----
L
P
K
-
D
A
---
E
-
E
K
V
-
G
A
R
R
V
EN
I
E
E
L
V
A
Q
A
D
I
V
T
V
N
A
P
L
H
A
G
T
K
G
L
I
N
K
E
L
L
S
K
F
K
K
G
A
W
L
V
N
T
A
R
G
A
I
C
V
A
E
D
V
A
A
A
L
E
S
G
Q
L
R
G
Y
G
G
D
V
W
F
P
Q
P
A
P
K
D
H
P
W
R
D
M
R
N
-----
K
YGAGN
A
M
T
P
H
Y
S
G
T
T
L
D
A
Q
T
R
Y
-
A
Q
G
T
V
N
I
L
E
S
F
F
T
G
K
-
F
D
Y
R
P
Q
D
I
I
L
L
N
G
E
Y
-----------
42
PsiBlast_CBE
85.60
45%
-100
- C2 -
2J6I
1
FDH_CANBO
C:
[24-353]
-------------------------------------------------------------
T
E
N
K
-
L
-
G
I
A
N
W
L
K
D
Q
G
H
E
L
I
T
T
S
D
KEG-------
N
S
V
--
L
D
Q
H
I
P
D
A
D
I
I
I
T
T
P
F
H
P
A
Y
I
T
K
E
R
I
D
K
A
K
K
-
L
K
L
V
V
V
A
G
V
G
S
D
H
I
D
L
D
Y
I
N
Q
TG
K
K
--
I
S
V
L
E
V
T
G
S
N
V
V
S
V
A
E
H
V
V
M
T
M
L
V
L
V
R
N
F
V
P
A
H
E
Q
I
I
N
H
D
-
W
E
V
A
A
I
-
A
K
D
A
Y
D
I
E
G
K
T
I
A
T
I
G
A
G
R
I
G
Y
R
V
L
E
R
L
V
P
F
N
P
K
E
L
----
L
Y
Y
D
YQAL-
P
-----
K
D
-
A
----
E
E
K
-
V
G
---
A
-
R
R
V
E
N
------
I
E
E
L
V
A
Q
A
D
I
V
T
V
N
A
P
L
H
A
G
T
K
G
L
I
N
K
E
L
L
S
K
F
K
K
G
A
W
L
V
N
T
A
R
G
A
I
C
V
A
E
D
V
A
A
A
L
E
S
G
Q
L
R
G
Y
G
G
D
V
W
F
P
Q
P
A
P
K
D
H
P
W
R
D
M
R
N
KYGAG
N
-----
A
M
T
P
H
Y
S
G
T
T
L
D
A
Q
T
R
Y
-
A
Q
G
T
V
N
I
L
E
S
F
F
T
G
K
F
D
Y
-
R
P
Q
D
I
I
L
L
N
G
E
Y
-----------
2
PsiBlast_PDB
85.55
45%
-95
- C2 -
2NAC
1
FDH_PSESR
A:
[39-374]
--------------------------------------------
P
K
A
I
D
---
F
T
P
G
Q
L
L
-
G
S
V
S
G
E
L
-
G
L
R
K
Y
L
E
S
N
G
H
T
L
V
V
T
S
D
K-----
D
---
G
P
D
S
V
F
E
R
E
L
V
D
A
D
V
V
I
S
Q
P
F
W
P
A
Y
L
T
P
E
R
I
A
K
A
K
N
-
L
K
L
A
L
T
A
G
I
G
S
D
H
V
D
L
Q
S
A
I
D
--
R
N
--
V
T
V
A
E
V
T
Y
C
N
S
I
S
V
A
E
H
V
V
M
M
I
L
S
L
V
R
N
Y
L
P
S
H
E
W
A
R
K
G
G
-
W
N
I
A
D
C
-
V
S
H
A
Y
D
L
E
A
M
H
V
G
T
V
A
A
G
R
I
G
L
A
V
L
R
R
L
A
P
F
D
V
H
-
L
----
H
Y
T
D
RHRL-
P
-----
E
S
V
E
----
K
E
L
-
N
L
---
T
-
W
H
A
-
T
------
R
E
D
M
Y
P
V
C
D
V
V
T
L
N
C
P
L
H
P
E
T
E
H
M
I
N
D
E
T
L
K
L
F
K
R
G
A
Y
I
V
N
T
A
R
G
K
L
C
D
R
D
A
V
A
R
A
L
E
S
G
R
L
A
G
Y
A
G
D
V
W
F
P
Q
P
A
P
K
D
H
P
W
R
T
M
P
Y
-----
N
-----
G
M
T
P
H
I
S
G
T
T
L
T
A
Q
A
R
Y
-
A
A
G
T
R
E
I
L
E
C
F
F
E
G
R
-
P
I
-
R
D
E
Y
L
I
V
Q
G
G
A
L
A
----------
13
PsiBlast_PDB
85.42
45%
-102
- C2 -
2FSS
2
FDH_CANBO
A:
[25-354]
-------------------------------------------------------------
T
E
N
K
-
L
-
G
I
A
N
W
L
K
D
Q
G
H
E
L
I
T
T
S
D
EEG---
G
---
N
S
V
--
L
D
Q
H
I
P
D
A
D
I
I
I
T
T
P
F
H
P
A
Y
I
T
K
E
R
I
D
K
A
K
K
-
L
K
L
V
V
V
A
G
V
G
S
D
H
I
D
L
D
Y
I
N
Q
T
G
K
K
--
I
S
V
L
E
V
T
G
S
N
V
V
S
V
A
E
H
V
V
M
T
M
L
V
L
V
R
N
F
V
P
A
H
E
Q
I
I
N
H
D
-
W
E
V
A
A
I
-
A
K
D
A
Y
D
I
E
G
K
T
I
A
T
I
G
A
G
R
I
G
Y
R
V
L
E
R
L
V
P
F
N
P
K
E
L
----
L
Y
Y
D
YQAL-
P
-----
K
D
-
A
----
E
E
K
-
V
G
---
A
-
R
R
V
E
N
------
I
E
E
L
V
A
Q
A
D
I
V
T
V
N
A
P
L
H
A
G
T
K
G
L
I
N
K
E
L
L
S
K
F
K
K
G
A
W
L
V
N
T
A
R
G
A
I
C
V
A
E
D
V
A
A
A
L
E
S
G
Q
L
R
G
Y
G
G
D
V
W
F
P
Q
P
A
P
K
D
H
P
W
R
D
M
R
N
KYGAG
N
-----
A
M
T
P
H
Y
S
G
T
T
L
D
A
Q
T
R
Y
-
A
Q
G
T
K
N
I
L
E
S
F
F
T
G
K
F
D
Y
-
R
P
Q
D
I
I
L
L
N
G
E
Y
-----------
12
PsiBlast_PDB
85.23
46%
-95
- C2 -
4XYG
-
?
A:
[40-377]
--------------------------------------------
P
K
H
I
D
---
F
V
P
G
E
L
L
-
G
C
V
S
G
E
L
-
G
L
R
S
Y
L
E
D
L
G
H
T
F
I
V
T
S
D
------
K
EGP
N
S
V
--
F
E
K
E
L
P
D
A
D
I
V
I
S
Q
P
F
W
P
A
Y
L
T
A
E
R
I
A
K
A
K
K
-
L
K
L
A
L
T
A
G
I
G
S
D
H
V
D
L
N
A
A
I
K
--
A
G
--
I
T
V
A
E
E
T
F
S
N
G
I
C
V
A
E
H
A
V
M
M
I
L
A
L
V
R
N
Y
L
P
S
H
K
I
A
E
E
G
G
-
W
N
I
A
D
C
-
V
S
R
S
Y
D
L
E
G
M
H
V
G
T
V
A
A
G
R
I
G
L
A
V
L
R
R
L
K
P
F
D
V
K
-
L
H
Y
T
A
R
H
R
S
-----
P
-----
R
A
-
I
----
E
D
E
L
G
L
---
T
-
Y
H
A
-
T
------
A
E
E
M
A
E
V
C
D
V
I
S
I
H
A
P
L
Y
P
A
T
E
H
L
F
N
A
K
V
L
N
K
M
R
H
G
S
Y
L
V
N
T
A
R
A
E
I
C
D
R
D
D
I
V
R
A
L
E
S
G
Q
L
A
G
Y
A
G
D
V
W
F
P
Q
P
A
P
A
N
H
P
W
R
N
M
P
H
-----
N
-----
G
M
T
P
H
M
S
G
S
S
L
S
G
Q
A
R
Y
-
A
A
G
T
R
E
I
L
E
C
W
F
E
N
R
-
P
I
-
R
D
E
Y
L
I
V
S
N
G
K
L
A
GT--------
14
PsiBlast_PDB
84.92
45%
-99
- C2 -
2J6I
1
FDH_CANBO
A:
[24-353]
-------------------------------------------------------------
T
E
N
K
-
L
-
G
I
A
N
W
L
K
D
Q
G
H
E
L
I
T
T
S
D
KEG---
G
---
N
S
V
--
L
D
Q
H
I
P
D
A
D
I
I
I
T
T
P
F
H
P
A
Y
I
T
K
E
R
I
D
K
A
K
K
-
L
K
L
V
V
V
A
G
V
G
S
D
H
I
D
L
D
Y
I
N
Q
T
G
K
K
--
I
S
V
L
E
V
T
G
S
N
V
V
S
V
A
E
H
V
V
M
T
M
L
V
L
V
R
N
F
V
P
A
H
E
Q
I
I
N
H
D
-
W
E
V
A
A
I
-
A
K
D
A
Y
D
I
E
G
K
T
I
A
T
I
G
A
G
R
I
G
Y
R
V
L
E
R
L
V
P
F
N
P
K
E
L
----
L
Y
Y
D
YQAL-
P
-----
K
D
-
A
----
E
E
K
-
V
G
---
A
-
R
R
V
E
N
------
I
E
E
L
V
A
Q
A
D
I
V
T
V
N
A
P
L
H
A
G
T
K
G
L
I
N
K
E
L
L
S
K
F
K
K
G
A
W
L
V
N
T
A
R
G
A
I
C
V
A
E
D
V
A
A
A
L
E
S
G
Q
L
R
G
Y
G
G
D
V
W
F
P
Q
P
A
P
K
D
H
P
W
R
D
M
R
N
KYGAG
N
-----
A
M
T
P
H
Y
S
G
T
T
L
D
A
Q
T
R
Y
-
A
Q
G
T
V
N
I
L
E
S
F
F
T
G
K
F
D
Y
-
R
P
Q
D
I
I
L
L
N
G
E
Y
-----------
11
PsiBlast_PDB
84.64
46%
-94
- C2 -
4XYE
1
?
A:
[40-382]
--------------------------------------------
P
K
H
I
D
---
F
V
P
G
E
L
L
-
G
C
V
S
G
E
L
-
G
L
R
S
Y
L
E
D
L
G
H
T
F
I
V
T
S
D
------
K
EGP
N
S
V
--
F
E
K
E
L
P
D
A
D
I
V
I
S
Q
P
F
W
P
A
Y
L
T
A
E
R
I
A
K
A
K
K
-
L
K
L
A
L
T
A
G
I
G
S
D
H
V
D
L
N
A
A
I
K
--
A
G
--
I
T
V
A
E
E
T
F
S
N
G
I
C
V
A
E
H
A
V
M
M
I
L
A
L
V
R
N
Y
L
P
S
H
K
I
A
E
E
G
G
-
W
N
I
A
D
C
-
V
S
R
S
Y
D
L
E
G
M
H
V
G
T
V
A
A
G
R
I
G
L
A
V
L
R
R
L
K
P
F
D
V
K
-
L
H
Y
T
A
R
H
R
S
-----
P
-----
R
A
-
I
----
E
D
E
L
G
L
---
T
-
Y
H
A
-
T
------
A
E
E
M
A
E
V
C
D
V
I
S
I
H
A
P
L
Y
P
A
T
E
H
L
F
N
A
K
V
L
N
K
M
R
H
G
S
Y
L
V
N
T
A
R
A
E
I
C
D
R
D
D
I
V
R
A
L
E
S
G
Q
L
A
G
Y
A
G
D
V
W
F
P
Q
P
A
P
A
N
H
P
W
R
N
M
P
H
-----
N
-----
G
M
T
P
H
M
S
G
S
S
L
S
G
Q
A
R
Y
-
A
A
G
T
R
E
I
L
E
C
W
F
E
N
R
-
P
I
-
R
D
E
Y
L
I
V
S
N
G
K
L
A
GTG
A
K
S
Y
---
38
PsiBlast_CBE
84.36
46%
-94
- C2 -
4XYB
4
?
B:
[40-382]
--------------------------------------------
P
K
H
I
D
---
F
V
P
G
E
L
L
-
G
C
V
S
G
E
L
-
G
L
R
S
Y
L
E
D
L
G
H
T
F
I
V
T
S
D
------
K
EGP
N
S
V
--
F
E
K
E
L
P
D
A
D
I
V
I
S
Q
P
F
W
P
A
Y
L
T
A
E
R
I
A
K
A
K
K
-
L
K
L
A
L
T
A
G
I
G
S
D
H
V
D
L
N
A
A
I
K
--
A
G
--
I
T
V
A
E
E
T
F
S
N
G
I
C
V
A
E
H
A
V
M
M
I
L
A
L
V
R
N
Y
L
P
S
H
K
I
A
E
E
G
G
-
W
N
I
A
D
C
-
V
S
R
S
Y
D
L
E
G
M
H
V
G
T
V
A
A
G
R
I
G
L
A
V
L
R
R
L
K
P
F
D
V
K
-
L
HYTA
R
H
R
S
-----
P
-----
R
A
-
I
----
E
D
E
L
G
L
---
T
-
Y
H
A
-
T
------
A
E
E
M
A
E
V
C
D
V
I
S
I
H
A
P
L
Y
P
A
T
E
H
L
F
N
A
K
V
L
N
K
M
R
H
G
S
Y
L
V
N
T
A
R
A
E
I
C
D
R
D
D
I
V
R
A
L
E
S
G
Q
L
A
G
Y
A
G
D
V
W
F
P
Q
P
A
P
A
N
H
P
W
R
N
M
P
H
-----
N
-----
G
M
T
P
H
M
S
G
S
S
L
S
G
Q
A
R
Y
-
A
A
G
T
R
E
I
L
E
C
W
F
E
N
R
-
P
I
-
R
D
E
Y
L
I
V
S
N
G
K
L
A
GTG
A
K
S
Y
---
41
PsiBlast_CBE
84.26
45%
-102
- C2 -
2J6I
1
FDH_CANBO
D:
[24-353]
-------------------------------------------------------------
T
E
N
K
-
L
-
G
I
A
N
W
L
K
D
Q
G
H
E
L
I
T
T
S
D
KEG-------
N
S
V
--
L
D
Q
H
I
P
D
A
D
I
I
I
T
T
P
F
H
P
A
Y
I
T
K
E
R
I
D
K
A
K
K
-
L
K
L
V
V
V
A
G
V
G
S
D
H
I
D
L
D
Y
I
N
Q
TG
K
K
--
I
S
V
L
E
V
T
G
S
N
V
V
S
V
A
E
H
V
V
M
T
M
L
V
L
V
R
N
F
V
P
A
H
E
Q
I
I
N
H
D
-
W
E
V
A
A
I
-
A
K
D
A
Y
D
I
E
G
K
T
I
A
T
I
G
A
G
R
I
G
Y
R
V
L
E
R
L
V
P
F
N
P
K
E
L
----
L
Y
Y
D
YQAL-
P
-----
K
D
-
A
----
E
E
K
-
V
G
---
A
-
R
R
V
E
N
------
I
E
E
L
V
A
Q
A
D
I
V
T
V
N
A
P
L
H
A
G
T
K
G
L
I
N
K
E
L
L
S
K
F
K
K
G
A
W
L
V
N
T
A
R
G
A
I
C
V
A
E
D
V
A
A
A
L
E
S
G
Q
L
R
G
Y
G
G
D
V
W
F
P
Q
P
A
P
K
D
H
P
W
R
D
M
R
N
KYGAG
N
-----
A
M
T
P
H
Y
S
G
T
T
L
D
A
Q
T
R
Y
-
A
Q
G
T
V
N
I
L
E
S
F
F
T
G
K
F
D
Y
-
R
P
Q
D
I
I
L
L
N
G
E
Y
-----------
21
PsiBlast_CBE
84.07
45%
-95
- C2 -
2NAD
3
FDH_PSESR
B:
[39-375]
--------------------------------------------
P
K
A
I
D
---
F
T
P
G
Q
L
L
-
G
S
V
S
G
E
L
-
G
L
R
K
Y
L
E
S
N
G
H
T
L
V
V
T
S
D
K-----
D
---
G
P
D
SV
F
E
R
E
L
V
D
A
D
V
V
I
S
Q
P
F
W
P
A
Y
L
T
P
E
R
I
A
K
A
K
N
-
L
K
L
A
L
T
A
G
I
G
S
D
H
V
D
L
Q
S
A
I
D
--
R
N
--
V
T
V
A
E
V
T
Y
C
N
S
I
S
V
A
E
H
V
V
M
M
I
L
S
L
V
R
N
Y
L
P
S
H
E
W
A
R
K
G
G
-
W
N
I
A
D
C
-
V
S
H
A
Y
D
L
E
A
M
H
V
G
T
V
A
A
G
R
I
G
L
A
V
L
R
R
L
A
P
F
D
V
H
-
L
----
H
Y
T
D
RHRL-
P
-----
E
S
V
E
----
K
E
L
-
N
L
---
T
-
W
H
A
-
T
------
R
E
D
M
Y
P
V
C
D
V
V
T
L
N
C
P
L
H
P
E
T
E
H
M
I
N
D
E
T
L
K
L
F
K
R
G
A
Y
I
V
N
T
A
R
G
K
L
C
D
R
D
A
V
A
R
A
L
E
S
G
R
L
A
G
Y
A
G
D
V
W
F
P
Q
P
A
P
K
D
H
P
W
R
T
M
P
Y
-----
N
-----
G
M
T
P
H
I
S
G
T
T
L
T
A
Q
A
R
Y
-
A
A
G
T
R
E
I
L
E
C
F
F
E
G
R
-
P
I
-
R
D
E
Y
L
I
V
Q
G
G
A
L
A
---
G
------
37
PsiBlast_CBE
83.98
46%
-92
- C2 -
4XYE
1
?
B:
[40-382]
--------------------------------------------
P
K
H
I
D
---
F
V
P
G
E
L
L
-
G
C
V
S
G
E
L
-
G
L
R
S
Y
L
E
D
L
G
H
T
F
I
V
T
S
D
------
K
EGP
N
S
V
--
F
E
K
E
L
P
D
A
D
I
V
I
S
Q
P
F
W
P
A
Y
L
T
A
E
R
I
A
K
A
K
K
-
L
K
L
A
L
T
A
G
I
G
S
D
H
V
D
L
N
A
A
I
K
--
A
G
--
I
T
V
A
E
E
T
F
S
N
G
I
C
V
A
E
H
A
V
M
M
I
L
A
L
V
R
N
Y
L
P
S
H
K
I
A
E
E
G
G
-
W
N
I
A
D
C
-
V
S
R
S
Y
D
L
E
G
M
H
V
G
T
V
A
A
G
R
I
G
L
A
V
L
R
R
L
K
P
F
D
V
K
-
L
HYTA
R
H
R
S
-----
P
-----
R
A
-
I
----
E
D
E
L
G
L
---
T
-
Y
H
A
-
T
------
A
E
E
M
A
E
V
C
D
V
I
S
I
H
A
P
L
Y
P
A
T
E
H
L
F
N
A
K
V
L
N
K
M
R
H
G
S
Y
L
V
N
T
A
R
A
E
I
C
D
R
D
D
I
V
R
A
L
E
S
G
Q
L
A
G
Y
A
G
D
V
W
F
P
Q
P
A
P
A
N
H
P
W
R
N
M
P
H
-----
N
-----
G
M
T
P
H
M
S
G
S
S
L
S
G
Q
A
R
Y
-
A
A
G
T
R
E
I
L
E
C
W
F
E
N
R
-
P
I
-
R
D
E
Y
L
I
V
S
N
G
K
L
A
GTG
A
K
S
Y
---
10
PsiBlast_PDB
83.60
46%
-92
- C2 -
4XYB
6
?
A:
[40-382]
--------------------------------------------
P
K
H
I
D
---
F
V
P
G
E
L
L
-
G
C
V
S
G
E
L
-
G
L
R
S
Y
L
E
D
L
G
H
T
F
I
V
T
S
D
------
K
EGP
N
S
V
--
F
E
K
E
L
P
D
A
D
I
V
I
S
Q
P
F
W
P
A
Y
L
T
A
E
R
I
A
K
A
K
K
-
L
K
L
A
L
T
A
G
I
G
S
D
H
V
D
L
N
A
A
I
K
--
A
G
--
I
T
V
A
E
E
T
F
S
N
G
I
C
V
A
E
H
A
V
M
M
I
L
A
L
V
R
N
Y
L
P
S
H
K
I
A
E
E
G
G
-
W
N
I
A
D
C
-
V
S
R
S
Y
D
L
E
G
M
H
V
G
T
V
A
A
G
R
I
G
L
A
V
L
R
R
L
K
P
F
D
V
K
-
L
H
Y
T
A
R
H
R
S
-----
P
-----
R
A
-
I
----
E
D
E
L
G
L
---
T
-
Y
H
A
-
T
------
A
E
E
M
A
E
V
C
D
V
I
S
I
H
A
P
L
Y
P
A
T
E
H
L
F
N
A
K
V
L
N
K
M
R
H
G
S
Y
L
V
N
T
A
R
A
E
I
C
D
R
D
D
I
V
R
A
L
E
S
G
Q
L
A
G
Y
A
G
D
V
W
F
P
Q
P
A
P
A
N
H
P
W
R
N
M
P
H
-----
N
-----
G
M
T
P
H
M
S
G
S
S
L
S
G
Q
A
R
Y
-
A
A
G
T
R
E
I
L
E
C
W
F
E
N
R
-
P
I
-
R
D
E
Y
L
I
V
S
N
G
K
L
A
GTG
A
K
S
Y
---
3
PsiBlast_PDB
83.52
45%
-91
- C2 -
2NAD
2
FDH_PSESR
A:
[39-375]
--------------------------------------------
P
K
A
I
D
---
F
T
P
G
Q
L
L
-
G
S
V
S
G
E
L
-
G
L
R
K
Y
L
E
S
N
G
H
T
L
V
V
T
S
D
K-----
D
---
G
P
D
S
V
F
E
R
E
L
V
D
A
D
V
V
I
S
Q
P
F
W
P
A
Y
L
T
P
E
R
I
A
K
A
K
N
-
L
K
L
A
L
T
A
G
I
G
S
D
H
V
D
L
Q
S
A
I
D
--
R
N
--
V
T
V
A
E
V
T
Y
C
N
S
I
S
V
A
E
H
V
V
M
M
I
L
S
L
V
R
N
Y
L
P
S
H
E
W
A
R
K
G
G
-
W
N
I
A
D
C
-
V
S
H
A
Y
D
L
E
A
M
H
V
G
T
V
A
A
G
R
I
G
L
A
V
L
R
R
L
A
P
F
D
V
H
-
L
----
H
Y
T
D
RHRL-
P
-----
E
S
V
E
----
K
E
L
-
N
L
---
T
-
W
H
A
-
T
------
R
E
D
M
Y
P
V
C
D
V
V
T
L
N
C
P
L
H
P
E
T
E
H
M
I
N
D
E
T
L
K
L
F
K
R
G
A
Y
I
V
N
T
A
R
G
K
L
C
D
R
D
A
V
A
R
A
L
E
S
G
R
L
A
G
Y
A
G
D
V
W
F
P
Q
P
A
P
K
D
H
P
W
R
T
M
P
Y
-----
N
-----
G
M
T
P
H
I
S
G
T
T
L
T
A
Q
A
R
Y
-
A
A
G
T
R
E
I
L
E
C
F
F
E
G
R
-
P
I
-
R
D
E
Y
L
I
V
Q
G
G
A
L
A
---
G
------
8
PsiBlast_PDB
83.25
45%
-96
- C2 -
2GSD
2
?
A:
[40-376]
--------------------------------------------
P
K
A
I
D
---
F
T
P
G
A
L
L
-
G
S
V
S
G
E
L
-
G
L
R
K
Y
L
E
S
Q
G
H
E
L
V
V
T
S
S
K-----
D
---
G
P
D
S
E
L
E
K
H
L
H
D
A
E
V
I
I
S
Q
P
F
W
P
A
Y
L
T
A
E
R
I
A
K
A
P
K
-
L
K
L
A
L
T
A
G
I
G
S
D
H
V
D
L
Q
A
A
I
D
--
N
N
--
I
T
V
A
E
V
T
Y
C
N
S
N
S
V
A
E
H
V
V
M
M
V
L
G
L
V
R
N
Y
I
P
S
H
D
W
A
R
N
G
G
-
W
N
I
A
D
C
-
V
A
R
S
Y
D
V
E
G
M
H
V
G
T
V
A
A
G
R
I
G
L
R
V
L
R
L
L
A
P
F
D
M
H
-
L
----
H
Y
T
D
RHRLP
E
-----
A
V
-
E
----
K
E
L
-
N
L
---
T
-
W
H
A
-
T
------
R
E
D
M
Y
G
A
C
D
V
V
T
L
N
C
P
L
H
P
E
T
E
H
M
I
N
D
E
T
L
K
L
F
K
R
G
A
Y
L
V
N
T
A
R
G
K
L
C
D
R
D
A
I
V
R
A
L
E
S
G
R
L
A
G
Y
A
G
D
V
W
F
P
Q
P
A
P
N
D
H
P
W
R
T
M
P
H
-----
N
-----
G
M
T
P
H
I
S
G
T
S
L
S
A
Q
T
R
Y
-
A
A
G
T
R
E
I
L
E
C
Y
F
E
G
R
-
P
I
-
R
D
E
Y
L
I
V
Q
G
G
G
L
A
---
G
------
9
PsiBlast_PDB
81.86
45%
-96
- C2 -
3FN4
2
?
A:
[39-375]
--------------------------------------------
P
K
A
I
D
---
F
T
P
G
A
L
L
-
G
S
V
S
G
E
L
-
G
L
R
K
Y
L
E
S
Q
G
H
E
L
V
V
T
S
S
K-----
D
---
G
P
D
S
E
L
E
K
H
L
H
D
A
E
V
I
I
S
Q
P
F
W
P
A
Y
L
T
A
E
R
I
A
K
A
P
K
-
L
K
L
A
L
T
A
G
I
G
S
D
H
V
D
L
Q
A
A
I
D
--
N
N
--
I
T
V
A
E
V
T
Y
C
N
S
N
S
V
A
E
H
V
V
M
M
V
L
G
L
V
R
N
Y
I
P
S
H
D
W
A
R
N
G
G
-
W
N
I
A
D
C
-
V
A
R
S
Y
D
V
E
G
M
H
V
G
T
V
A
A
G
R
I
G
L
R
V
L
R
L
L
A
P
F
D
M
H
-
L
----
H
Y
T
D
RHRLP
E
-----
A
V
-
E
----
K
E
L
-
N
L
---
T
-
W
H
A
-
T
------
R
E
D
M
Y
G
A
C
D
V
V
T
L
N
C
P
L
H
P
E
T
E
H
M
I
N
D
E
T
L
K
L
F
K
R
G
A
Y
L
V
N
T
A
R
G
K
L
C
D
R
D
A
I
V
R
A
L
E
S
G
R
L
A
G
Y
A
G
D
V
W
F
P
Q
P
A
P
N
D
H
P
W
R
T
M
P
H
-----
N
-----
G
M
T
P
H
I
S
G
T
S
L
S
A
Q
T
R
Y
-
A
A
G
T
R
E
I
L
E
C
Y
F
E
G
R
-
P
I
-
R
D
E
Y
L
I
V
Q
G
G
G
L
A
---
G
------
56
PsiBlast_CBE
53.89
35%
-83
- C2 -
2CUK
1
?
C:
[58-306]
----------------------------------------------------------------------------------------------------------------------------
E
V
M
D
R
A
K
G
-
L
K
V
I
A
C
Y
S
V
G
V
D
H
V
D
L
E
A
A
R
E
--
R
G
--
I
R
V
T
H
T
P
G
V
L
T
E
A
T
A
D
L
T
L
A
L
L
L
A
V
A
R
R
V
V
E
G
A
A
Y
A
R
D
G
L
-
W
K
A
W
H
P
E
L
L
L
G
L
D
L
Q
G
L
T
L
G
L
V
G
M
G
R
I
G
Q
A
V
A
K
R
A
L
A
F
G
M
R
-
V
----
V
Y
H
-------------
A
-
R
----
T
P
K
-
P
L
---
P
Y
P
F
L
-
S
------
L
E
E
L
L
K
E
A
D
V
V
S
L
H
T
P
L
T
P
E
T
H
R
L
L
N
R
E
R
L
F
A
M
K
R
G
A
I
L
L
N
T
A
R
G
A
L
V
D
T
E
A
L
V
E
A
L
R
G
-
H
L
F
G
A
G
L
D
V
T
D
P
E
P
L
P
P
G
H
P
L
Y
A
L
P
N
-----
A
-----
V
I
T
P
H
I
G
S
A
G
R
T
T
R
E
R
M
A
E
V
A
V
E
N
L
L
A
V
L
E
G
R
E
-
P
-------------------------
19
PsiBlast_PDB
52.50
38%
-83
- C2 -
1WWK
1
?
A:
[56-292]
-------------------------------------------------------------------------------------------------------------------------
V
T
R
R
V
I
E
S
A
P
K
-
L
K
V
I
A
R
A
G
V
G
L
D
N
I
D
V
E
A
A
K
E
--
K
G
--
I
E
V
V
N
A
P
A
A
S
S
R
S
V
A
E
L
A
V
G
L
M
F
S
V
A
R
K
I
A
F
A
D
R
K
M
R
E
G
V
-
W
A
K
K
E
A
---
M
G
I
E
L
E
G
K
T
I
G
I
I
G
F
G
R
I
G
Y
Q
V
A
K
I
A
N
A
L
G
M
N
-
I
----
L
L
Y
D
-----
P
-----
Y
P
-
N
----
E
E
R
-
A
K
E
V
N
G
-
K
F
V
-
D
------
L
E
T
L
L
K
E
S
D
V
V
T
I
H
V
P
L
V
E
S
T
Y
H
L
I
N
E
E
R
L
K
L
M
K
K
T
A
I
L
I
N
T
S
R
G
P
V
V
D
T
N
A
L
V
K
A
L
K
E
G
W
I
A
G
A
G
L
D
V
F
E
E
E
P
L
P
K
D
H
P
L
T
K
F
D
N
-----
V
-----
V
L
T
P
H
I
G
A
S
T
V
E
A
Q
E
R
--------------------------------------------
46
PsiBlast_CBE
52.08
38%
-86
- C2 -
1WWK
1
?
B:
[56-292]
-------------------------------------------------------------------------------------------------------------------------
V
T
R
R
V
I
E
S
A
P
K
-
L
K
V
I
A
R
A
G
V
G
L
D
N
I
D
V
E
A
A
K
E
--
K
G
--
I
E
V
V
N
A
P
A
A
S
S
R
S
V
A
E
L
A
V
G
L
M
F
S
V
A
R
K
I
A
F
A
D
R
K
M
R
E
G
V
-
W
A
K
K
E
A
---
M
G
I
E
L
E
G
K
T
I
G
I
I
G
F
G
R
I
G
Y
Q
V
A
K
I
A
N
A
L
G
M
N
-
I
----
L
L
Y
D
-----
P
-----
Y
P
-
N
----
E
E
R
-
A
K
EVN
G
-
K
F
V
-
D
------
L
E
T
L
L
K
E
S
D
V
V
T
I
H
V
P
L
V
E
S
T
Y
H
L
I
N
E
E
R
L
K
L
M
K
K
T
A
I
L
I
N
T
S
R
G
P
V
V
D
T
N
A
L
V
K
A
L
K
E
G
W
I
A
G
A
G
L
D
V
F
E
E
E
P
L
P
K
D
H
P
L
T
K
F
D
N
-----
V
-----
V
L
T
P
H
I
G
A
S
T
V
E
A
Q
E
R
--------------------------------------------