@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : SA0224: (2016-03-13 )
MTINKVTVLGAGTMGAQLAALFVNAGLKVKLLDIVVDKNDPNLIAKKSYDKITDKKRPLLFDLNLVSHLTYGNFDDDLVNDDADLYIEAVKEDIEIKHAVWQQVLQHAKEDALFATNTSGIPINAIAQAFNEKDQERFFGLHFFNPPRIMKLVELIPTSHTKESIILDVKNFAQNVLGKGVIVVNDVPGFVANRVGTQTMNDIMYRAEQHKLSIVDVDALTGQAIGRPKTGTYALSDLVGLDIAVSVIKGMQQVPEETPYFHDVKIVNTLFDNGALGRKTKQGFYKKDKETKARLVYDVEKQDYVPVSQPQLPILNEFNKDLVHNLDVIFNAQDEAGLFLWETLRNNFYYSAINVPKATDDFRDIDRALVWGFNWKLGPFQLWDAMGYERVKTRMEDELGDLPQWISDLDGGFYKQDETIEYATPVSHFVKDELWDKGDAKLSVTHDDQLLLKLQSKNNVITDEFNDALVDAIDLLENDHYTSMVIYADGNNFSVGANLFLMKKAHEDGLVDDVVAQSIDKLHYSFNRLKYSLKPVVTAVQGRALGGGCELVLYSPIVVAASETYIGLVEAGVGLLPSGGGLAEMADRILRTSHKFDDKQASMTKVLTNIAFAKVSTNAFEARRYGYLRDTDTIIFNTAQRVEVALKRAKYEAETNYIPNPRHQYIALGEDFKALIQGQLDAQRRGHFISDHDYHIALNIATILAGGDLPRNTFINQRYIQSLEKIGFIDLLKSKKSYERIAHMLKTGKPLRN
Atome Classification :
(28 SA)
.........10........20........30...----------.....40-.....------...50.....---.--..60.----.......70--.......--.80-.........90........100.......110.......120.......130.......140.......150.......160.......170.......180.......190.......200.......210.......220.......230.......240.......250.-...--.------..260.......270.......280.......290......--------------------------.300......---.310.--------------------......320......-...330.......340.......350....-.-..360.......370....---...380.......390......--------.400.......---410.......420.......430.......440.......450.......460.......470.......480.......490.......500.......510.......520.......530.......540.......550.......560.......570.......580.......590.......600.......610.......620.......630.......640.......650.......660.......670.......680.......690.......700.......710.......720.......730.......740.......750.
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MT
I
N
K
V
T
V
L
GAGT
M
G
A
Q
L
A
A
L
F
VNAG
L
K
V
K
L
L
D
I
----------
V
VDKNDP-
N
L
I
AK------K
S
Y
D
KITDKK---R--
P
L
L
F
D
----
L
N
L
V
S
H
L
TY--GNFDDDL--VN--D
D
A
D
L
Y
I
E
A
V
K
E
D
I
E
I
K
H
A
V
W
Q
Q
V
L
Q
H
AKED
A
L
F
ATNTSGI
P
I
N
A
I
A
Q
A
FN
E
K
D
Q
E
R
F
F
G
L
HFFN
P
P
R
I
M
K
L
V
E
L
IPTSHTK
E
S
I
I
L
D
V
K
N
F
A
Q
N
V
LGK
G
V
I
V
VNDV
P
G
F
V
A
N
RVGT
Q
T
M
N
D
I
M
Y
R
A
EQH
K
L
S
I
V
D
VDALTGQAIGRPKTG
T
Y
A
L
S
D
L
V
G
L
D
I
A
V
S
V
I
K
G
M
Q
Q-VPE--E------TPYFH
D
V
K
I
V
N
T
L
FDNGALGRKTKQGFYKKDKETK
A
R
L
V
Y
D--------------------------VEKQDYVPVS---QPQL
P
--------------------
I
L
N
E
F
N
K
--
D
L
V
HNL-
D
V
I
F
NAQDEA
G
L
F
L
W
E
T
L
RNN
F
Y
Y
S
AINVP-K-AT
D
D
F
R
D
I
D
R
A
L
V
W
GFNWK---L
G
P
F
Q
L
W
D
AM
G
Y
E
R
V
K
T
R
M
E
D
E
--------L
G
D
L
P
Q
W
I
S
DL---DGGFYKQDE
T
I
E
YAT
P
V
S
H
F
V
K
D
E
LWDKGD
A
K
L
S
VTHD
D
Q
L
L
L
K
LQSKN
N
V
I
T
D
EF
N
D
A
L
V
D
A
I
D
L
LENDH
Y
T
S
M
V
I
Y
ADGNN
F
S
VGA
N
L
F
L
M
K
KAHEDG
L
V
D
D
V
V
A
Q
S
I
D
K
L
H
Y
S
F
N
R
L
K
Y
S
L
K
P
V
V
T
A
VQGRALGGG
C
E
L
V
L
YS
P
I
V
V
A
ASE
T
Y
I
G
L
V
E
AGVGLLPSGG
G
L
A
E
M
A
D
R
I
L
R
TSHKFD
D
K
Q
A
S
M
T
K
V
L
T
N
I
A
F
A
KVSTN
A
F
E
A
R
RYGYLRDT
D
T
I
I
FN
T
A
Q
R
V
E
V
A
L
K
R
AKYEAETNYIPNPRH
Q
Y
I
AL
G
E
D
F
K
A
L
I
Q
G
Q
L
D
A
Q
RRGHFISDH
D
Y
H
I
A
L
N
I
A
T
ILAGGDLP
R
N
TF
I
N
Q
R
Y
I
Q
S
L
E
KI
G
F
I
D
L
L
K
SK
K
S
Y
E
R
I
A
H
M
L
KTGKPLRN
65
HHSearch
97.16
25%
-66
- C1 -
3MOG
1
PAAH_ECOLI
A:
[4-473]
-
N
V
Q
T
V
A
V
I
G
S
G
T
M
G
A
G
I
A
E
V
A
A
S
H
G
H
Q
V
L
L
Y
D
I
----------
S
A
E
A
L
T
R
A
I
D
G
I
H
------
A
R
L
N
S
R
V
T
R
G
---
K
L-
T
A
E
T
C
----
E
R
T
L
K
R
L
I
P
-----
V
T
D
I
--
H
A
L-
A
A
A
D
L
V
I
E
A
A
S
E
R
L
E
V
K
K
A
L
F
A
Q
L
A
E
V
C
P
P
Q
T
L
L
T
T
N
T
S
S
I
S
I
T
A
I
A
A
E
I
K
N
--
P
E
R
V
A
G
L
H
F
F
N
P
A
P
V
M
K
L
V
E
V
V
S
G
L
A
T
A
A
E
V
V
E
Q
L
C
E
L
T
L
-
S
W
G
K
Q
P
V
R
C
H
S
T
P
G
F
I
V
N
R
V
A
R
P
Y
Y
S
E
A
W
R
A
L
E
E
Q
V
A
A
P
E
V
I
D
A
A
L
R
D
G
A
G
F
P
-
M
G
P
L
E
L
T
D
L
I
G
Q
D
V
N
F
A
V
T
C
S
V
F
N
A
F
W
Q
--
E
-------
R
R
F
L
P
S
L
V
Q
Q
E
L
V
I
G
G
R
L
G
K
K
S
G
L
G
V
Y
D
W
R
A
E
R
E
A
V
V
G
L
E
AVSDSFSPM
K
V
E
K
K
SDG
V
T
E
I
DD
V
L
L
I
E
T
Q
G
E
T
A
Q
A
L
A
I
R
L
A
R
P
V
V
V
I
D
K
M
AGK
V
V
T
I
A
A
A
AVN
P
D
S
A
T
R
K
A
I
Y
Y
L
Q
Q
Q
G
K
T
V
L
Q
I
A
D
Y
P
G
M
L
I
W
R
T
V
A
M
I
I
N
E
A
L
D
A
L
Q
-
K
-
G
V
A
S
E
Q
D
I
D
T
A
M
R
L
G
V
N
Y
P
---
Y
G
P
L
A
W
G
A
Q
L
G
W
Q
R
I
L
R
L
L
E
N
L
Q
H
H
Y
GEE-
R
Y
R
P
C
S
L
L
R
Q
R
A
L
L
E
S
G
Y
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
67
HHSearch
85.28
24%
-66
- C1 -
1ZCJ
-
ECHP_RAT
A:
[295-700]
-
P
V
S
S
V
G
V
L
G
L
G
T
M
G
R
G
I
A
I
S
F
A
R
V
G
I
S
V
V
A
V
E
S
----------
D
P
K
Q
L
D
A
A
K
K
I
I
T
------
F
T
L
E
K
E
A
S
R
A
--------
H
Q
N
G
Q
--
A
S
A
K
P
K
L
R
F
-----
S
S
S
T
--
K
E
L-
S
T
V
D
L
V
V
E
A
V
F
E
D
M
N
L
K
K
K
V
F
A
E
L
S
A
L
C
K
P
G
A
F
L
C
T
N
T
S
A
L
N
V
D
D
I
A
S
S
T
D
R
--
P
Q
L
V
I
G
T
H
F
F
S
P
A
H
V
M
R
L
L
E
V
I
P
S
R
Y
S
S
P
T
T
I
A
T
V
M
S
L
S
K
-
K
I
G
K
I
G
V
V
V
G
N
C
Y
G
F
V
G
N
R
M
L
A
P
Y
Y
N
Q
G
F
F
L
L
-
E
E
G
S
K
P
E
D
V
D
G
V
L
E
-
E
F
G
F
K
-
M
G
P
F
R
V
S
D
L
A
G
L
D
V
G
W
K
I
R
K
G
Q
G
L
T
G
P
S
LP
P
GTPVRK
R
G
N
S
R
Y
S
P
L
G
D
M
L
C
E
A
G
R
F
G
Q
K
T
G
K
G
W
Y
Q
Y
D
K
P
L
G
R
I
H
K
P
D
--------------------------
P
W
L
S
T
F
L
S
Q
Y
---
R
-------------------------------------
E
V
-
H
H
I
E
Q
R
T
I
S
K
E
E
I
L
E
R
C
L
Y
S
L
I
N
E
A
F
R
I
L
E
-
E
G
M
A
A
R
P
E
H
I
D
V
I
Y
L
H
G
Y
G
W
P
RHK
G
G
P
M
F
Y
A
A
S
V
G
L
P
T
V
L
E
K
L
Q
K
Y
Y
R
Q
N
PDIP
Q
L
E
P
S
D
Y
L
R
R
L
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
70
HHSearch
79.42
32%
-69
- C1 -
1F0Y
3
HCDH_HUMAN
A:
[14-302]
-
I
V
K
H
V
T
V
I
G
G
G
L
M
G
A
G
I
A
Q
V
A
A
A
T
G
H
T
V
V
L
V
D
Q
----------
T
E
D
I
L
A
K
S
K
K
G
I
E
------
E
S
L
R
K
V
A
K
K
K
---
F
AE
N
P
K
A
G
D
E
F
V
E
K
T
L
S
T
I
A
T
-----
S
T
D
A
--
A
S
V
V
H
S
T
D
L
V
V
E
A
I
V
E
N
L
K
V
K
N
E
L
F
K
R
L
D
K
F
A
A
E
H
T
I
F
A
S
N
T
S
S
L
Q
I
T
S
I
A
N
A
T
T
R
--
Q
D
R
F
A
G
L
H
F
F
N
P
V
P
V
M
K
L
V
E
V
I
K
T
P
M
T
S
Q
K
T
F
E
S
L
V
D
F
S
K
-
A
L
G
K
H
P
V
S
C
K
D
T
P
G
F
I
V
N
R
L
L
V
P
Y
L
M
E
A
I
R
L
Y
E
R
G
D
A
S
K
E
D
I
D
T
A
M
K
L
G
A
G
Y
P
-
M
G
P
F
E
L
L
D
Y
V
G
L
D
T
T
K
F
I
V
D
G
W
H
E
M
D
A
E
---------
N
P
L
H
Q
P
S
P
S
L
N
K
L
V
A
E
N
K
F
G
K
K
T
G
E
G
F
Y
K
Y
K
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
2
PsiBlast_PDB
79.40
31%
-77
- C1 -
4J0F
-
HCDH1_CAEEL
A:
[14-299]
--
I
R
N
V
A
I
V
G
S
G
Q
M
G
S
G
I
A
Q
V
T
A
S
S
G
F
N
V
M
L
A
D
V
N
K
K
A
L
D
R
A
M
K
A
I
S
Q
S
V
T
-
H
L
S
K
K
------
Q
----
G
T
D
K
E
---
K
--
S
D
F
V
T
----
L
T
M
S
R
I
K
T
C
--
N
N
V
S
T
A
V
--
A
----
D
A
D
L
I
I
E
A
A
I
E
N
I
D
L
K
R
G
I
F
A
Q
I
E
Q
S
C
K
K
D
S
I
L
T
T
N
T
S
S
F
L
L
E
D
V
A
K
G
L
--
Q
D
K
T
R
F
G
G
L
H
F
F
N
P
V
P
V
M
K
L
L
E
V
I
R
S
D
D
T
S
D
E
T
Y
A
T
L
I
K
F
G
T
A
V
-
G
K
T
T
V
A
C
K
D
S
P
G
F
I
V
N
R
L
L
I
P
Y
F
F
E
A
A
R
M
Y
E
R
G
D
A
S
M
T
D
I
D
E
A
M
K
L
G
A
G
H
P
-
M
G
P
F
E
L
A
D
Y
I
G
L
D
T
V
K
F
V
M
D
G
W
A
A
-
K
Y
P
--
E
------
V
Q
L
F
E
A
S
P
L
V
D
K
L
V
A
E
G
K
L
G
R
K
T
G
D
G
F
Y
S
Y
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
38
PsiBlast_CBE
79.21
31%
-77
- C1 -
1IL0
3
HCDH_HUMAN
B:
[13-300]
I
I
V
K
H
V
T
V
I
G
G
G
L
M
G
A
G
I
A
Q
V
A
A
A
T
G
H
T
V
V
L
V
D
Q
----------
T
E
D
------
I
L
A
K
SKKGIE
E
S
L
R
K
V
A
K
K
K
FAE
N
--
P
K
A
G
D
----
E
F
V
E
K
T
L
S
T
IA
T
S
T
D
A
A
S
--
V
V
--
H
S
T
D
L
V
V
E
A
I
V
E
N
L
K
V
K
N
E
L
F
K
R
L
D
K
F
A
A
E
H
T
I
F
A
S
N
T
S
S
L
Q
I
T
S
I
A
N
A
T
T
R
Q
D
--
R
F
A
G
L
H
F
F
N
P
V
P
V
M
K
L
V
Q
V
I
K
T
P
M
T
S
Q
K
T
F
E
S
L
V
D
F
S
K
-
A
L
G
K
H
P
V
S
C
K
D
T
P
G
F
I
V
N
R
L
L
V
P
Y
L
M
E
A
I
R
L
Y
E
R
G
D
A
S
K
E
D
I
D
T
A
M
K
L
G
A
G
Y
P
-
M
G
P
F
E
L
L
D
Y
V
G
L
D
T
T
K
F
I
V
D
G
W
H
E
-
M
D
A
--
E
------
N
P
L
H
Q
P
S
P
S
L
N
K
L
V
A
E
N
K
F
G
K
K
T
G
E
G
F
Y
K
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
3
PsiBlast_PDB
78.75
31%
-78
- C1 -
3HDH
1
HCDH_PIG
A:
[15-300]
--
V
K
H
V
T
V
I
G
G
G
L
M
G
A
G
I
A
Q
V
A
A
A
T
G
H
T
V
V
L
V
D
Q
----------
T
E
D
------
I
L
A
K
S
K
K
G
I
E
E
S
L
R
K
V
A
K
K
K
F
A
E
N
--
P
K
A
G
D
----
E
F
V
E
K
T
L
S
S
--
I
S
T
S
T
D
A
AS
V
V
--
H
S
T
D
L
V
V
E
A
I
V
E
N
L
K
V
K
S
E
L
F
K
R
L
D
K
F
A
A
E
H
T
I
F
A
S
N
T
S
S
L
Q
I
T
S
L
A
N
A
T
T
R
Q
D
--
R
F
A
G
L
H
F
F
N
P
V
P
L
M
K
L
V
E
V
V
K
T
P
M
T
S
Q
K
T
L
E
S
L
V
D
F
S
K
T
-
L
G
K
H
P
V
S
C
K
D
T
P
G
F
I
V
N
R
L
L
V
P
Y
L
I
E
A
V
R
L
Y
E
R
G
D
A
S
K
E
D
I
D
T
A
M
K
L
G
A
G
Y
P
-
M
G
P
F
E
L
L
D
Y
V
G
L
D
T
T
K
F
I
I
D
G
W
H
E
-
M
D
S
--
Q
------
N
P
L
F
Q
P
S
P
A
M
N
K
L
V
A
E
N
K
F
G
K
K
T
G
E
G
F
Y
K
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
64
HHSearch
78.42
22%
-68
- C1 -
2WTB
-
MFP2_ARATH
A:
[311-718]
-
K
I
K
K
V
A
I
I
G
G
G
L
M
G
S
G
I
A
T
A
L
I
L
S
N
Y
P
V
I
L
K
E
V
----------
N
E
K
F
L
E
A
G
I
G
R
V
K
------
A
N
L
Q
S
R
V
R
--------
S
Q
E
K
F
----
E
K
T
M
S
L
L
K
G
-----
S
L
D
Y
--
E
S
F-
R
D
V
D
M
V
I
E
A
V
I
E
N
I
S
L
K
Q
Q
I
F
A
D
L
E
K
Y
C
P
Q
H
C
I
L
A
S
N
T
S
T
I
D
L
N
K
I
G
E
R
T
K
S
--
Q
D
R
I
V
G
A
H
F
F
S
P
A
H
I
M
P
L
L
E
I
V
R
T
N
H
T
S
A
Q
V
I
V
D
L
L
D
V
G
K
-
K
I
K
K
T
P
V
V
V
G
N
C
T
G
F
A
V
N
R
M
F
F
P
Y
T
Q
A
A
M
F
L
V
E
C
-
G
A
D
P
Y
L
I
D
R
A
I
S
K
-
F
G
M
P
-
M
G
P
F
R
L
C
D
L
V
G
F
G
V
A
I
A
T
A
T
Q
F
I
E
N
F
S
---
E
--------
R
T
Y
K
S
M
I
I
P
L
M
Q
E
D
K
-----------------------
D
--------------------------
P
E
L
K
K
Y
I
E
K
A
---
R
S
I
------------------------
S
------
G
V
K
L
D
----
P
K
L
A
N
L
S
E
K
D
I
I
E
M
T
F
F
P
V
V
N
E
A
C
R
V
F
A
E
G
-
I
A
V
K
A
A
D
L
D
I
A
G
I
M
G
M
G
F
P
PYR
G
G
I
M
F
W
A
D
S
I
G
S
K
Y
I
Y
S
R
L
D
E
W
S
K
A
YGE--
F
F
K
P
C
A
F
L
A
E
R
G
S
K
G
V
L
L
S
A
P
V
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
15
PsiBlast_PDB
78.35
31%
-81
- C1 -
1LSJ
1
HCDH_HUMAN
A:
[13-300]
I
I
V
K
H
V
T
V
I
G
G
G
L
M
G
A
G
I
A
Q
V
A
A
A
T
G
H
T
V
V
L
V
D
Q
----------
T
E
D
------
I
L
A
K
S
K
K
G
I
E
E
S
L
R
K
V
A
K
K
K
FAE
N
--
P
K
A
G
D
----
E
F
V
E
K
T
L
S
T
I
A
T
S
T
D
A
A
S
--
V
V
--
H
S
T
D
L
V
V
E
A
I
V
Q
N
L
K
V
K
N
E
L
F
K
R
L
D
K
F
A
A
E
H
T
I
F
A
S
N
T
S
S
L
Q
I
T
S
I
A
N
A
T
T
R
Q
D
--
R
F
A
G
L
H
F
F
N
P
V
P
V
M
K
L
V
E
V
I
K
T
P
M
T
S
Q
K
T
F
E
S
L
V
D
F
S
K
-
A
L
G
K
H
P
V
S
C
K
D
T
P
G
F
I
V
N
R
L
L
V
P
Y
L
M
E
A
I
R
L
Y
E
R
G
D
A
S
K
E
D
I
D
T
A
M
K
L
G
A
G
Y
P
-
M
G
P
F
E
L
L
D
Y
V
G
L
D
T
T
K
F
I
V
D
G
W
H
E
-
M
D
A
--
E
------
N
P
L
H
Q
P
S
P
S
L
N
K
L
V
A
E
N
K
F
G
K
K
T
G
E
G
F
Y
K
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
40
PsiBlast_CBE
78.23
31%
-79
- C1 -
1M75
3
HCDH_HUMAN
B:
[13-300]
I
I
V
K
H
V
T
V
I
G
G
G
L
M
G
A
G
I
A
Q
V
A
A
A
T
G
H
T
V
V
L
V
D
Q
----------
T
E
D
------
I
L
A
K
SKKGIE
E
S
L
R
K
V
A
K
K
K
FAE
N
--
P
K
A
G
D
----
E
F
V
E
K
T
L
S
T
IA
T
S
T
D
A
A
S
--
V
V
--
H
S
T
D
L
V
V
E
A
I
V
E
N
L
K
V
K
N
E
L
F
K
R
L
D
K
F
A
A
E
H
T
I
F
A
S
N
T
S
S
L
Q
I
T
S
I
A
N
A
T
T
R
Q
D
--
R
F
A
G
L
H
F
F
N
P
V
P
V
M
K
L
V
E
V
I
K
T
P
M
T
S
Q
K
T
F
E
S
L
V
D
F
S
K
-
A
L
G
K
H
P
V
S
C
K
D
T
P
G
F
I
V
S
R
L
L
V
P
Y
L
M
E
A
I
R
L
Y
E
R
G
D
A
S
K
E
D
I
D
T
A
M
K
L
G
A
G
Y
P
-
M
G
P
F
E
L
L
D
Y
V
G
L
D
T
T
K
F
I
V
D
G
W
H
E
-
M
D
A
--
E
------
N
P
L
H
Q
P
S
P
S
L
N
K
L
V
A
E
N
K
F
G
K
K
T
G
E
G
F
Y
K
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
21
PsiBlast_CBE
77.94
31%
-71
- C1 -
3HDH
1
HCDH_PIG
B:
[15-300]
--
V
K
H
V
T
V
I
G
G
G
L
M
G
A
G
I
A
Q
V
A
A
A
T
G
H
T
V
V
L
V
D
Q
----------
T
E
D
------
I
L
A
K
SKKGIE
E
S
L
R
K
V
A
K
K
K
FAE
N
--
P
K
A
G
D
----
E
F
V
E
K
T
L
S
S
--
I
S
T
S
T
D
A
AS
V
V
--
H
S
T
D
L
V
V
E
A
I
V
E
N
L
K
V
K
S
E
L
F
K
R
L
D
K
F
A
A
E
H
T
I
F
A
S
N
T
S
S
L
Q
I
T
S
L
A
N
A
T
T
R
Q
D
--
R
F
A
G
L
H
F
F
N
P
V
P
L
M
K
L
V
E
V
V
K
T
P
M
T
S
Q
K
T
L
E
S
L
V
D
F
S
K
T
-
L
G
K
H
P
V
S
C
K
D
T
P
G
F
I
V
N
R
L
L
V
P
Y
L
I
E
A
V
R
L
Y
E
R
G
D
A
S
K
E
D
I
D
T
A
M
K
L
G
A
G
Y
P
-
M
G
P
F
E
L
L
D
Y
V
G
L
D
T
T
K
F
I
I
D
G
W
H
E
-
M
D
S
--
Q
------
N
P
L
F
Q
P
S
P
A
M
N
K
L
V
A
E
N
K
F
G
K
K
T
G
E
G
F
Y
K
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
14
PsiBlast_PDB
77.78
31%
-74
- C1 -
1IL0
3
HCDH_HUMAN
A:
[13-300]
I
I
V
K
H
V
T
V
I
G
G
G
L
M
G
A
G
I
A
Q
V
A
A
A
T
G
H
T
V
V
L
V
D
Q
----------
T
E
D
------
I
L
A
K
S
K
K
G
I
E
E
S
L
R
K
V
A
K
K
K
F
A
E
N
--
P
K
A
G
D
----
E
F
V
E
K
T
L
S
T
I
A
T
S
T
D
A
A
S
--
V
V
--
H
S
T
D
L
V
V
E
A
I
V
E
N
L
K
V
K
N
E
L
F
K
R
L
D
K
F
A
A
E
H
T
I
F
A
S
N
T
S
S
L
Q
I
T
S
I
A
N
A
T
T
R
Q
D
--
R
F
A
G
L
H
F
F
N
P
V
P
V
M
K
L
V
Q
V
I
K
T
P
M
T
S
Q
K
T
F
E
S
L
V
D
F
S
K
-
A
L
G
K
H
P
V
S
C
K
D
T
P
G
F
I
V
N
R
L
L
V
P
Y
L
M
E
A
I
R
L
Y
E
R
G
D
A
S
K
E
D
I
D
T
A
M
K
L
G
A
G
Y
P
-
M
G
P
F
E
L
L
D
Y
V
G
L
D
T
T
K
F
I
V
D
G
W
H
E
-
M
D
A
--
E
------
N
P
L
H
Q
P
S
P
S
L
N
K
L
V
A
E
N
K
F
G
K
K
T
G
E
G
F
Y
K
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
8
PsiBlast_PDB
77.75
31%
-77
- C1 -
1F0Y
3
HCDH_HUMAN
A:
[13-300]
I
I
V
K
H
V
T
V
I
G
G
G
L
M
G
A
G
I
A
Q
V
A
A
A
T
G
H
T
V
V
L
V
D
Q
----------
T
E
D
------
I
L
A
K
S
K
K
G
I
E
E
S
L
R
K
V
A
K
K
K
FAE
N
--
P
K
A
G
D
----
E
F
V
E
K
T
L
S
T
I
A
T
S
T
D
A
A
S
--
V
V
--
H
S
T
D
L
V
V
E
A
I
V
E
N
L
K
V
K
N
E
L
F
K
R
L
D
K
F
A
A
E
H
T
I
F
A
S
N
T
S
S
L
Q
I
T
S
I
A
N
A
T
T
R
Q
D
--
R
F
A
G
L
H
F
F
N
P
V
P
V
M
K
L
V
E
V
I
K
T
P
M
T
S
Q
K
T
F
E
S
L
V
D
F
S
K
-
A
L
G
K
H
P
V
S
C
K
D
T
P
G
F
I
V
N
R
L
L
V
P
Y
L
M
E
A
I
R
L
Y
E
R
G
D
A
S
K
E
D
I
D
T
A
M
K
L
G
A
G
Y
P
-
M
G
P
F
E
L
L
D
Y
V
G
L
D
T
T
K
F
I
V
D
G
W
H
E
-
M
D
A
--
E
------
N
P
L
H
Q
P
S
P
S
L
N
K
L
V
A
E
N
K
F
G
K
K
T
G
E
G
F
Y
K
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
17
PsiBlast_PDB
77.60
31%
-77
- C1 -
1M75
3
HCDH_HUMAN
A:
[13-300]
I
I
V
K
H
V
T
V
I
G
G
G
L
M
G
A
G
I
A
Q
V
A
A
A
T
G
H
T
V
V
L
V
D
Q
----------
T
E
D
------
I
L
A
K
S
K
K
G
I
E
E
S
L
R
K
V
A
K
K
K
FAE
N
--
P
K
A
G
D
----
E
F
V
E
K
T
L
S
T
I
A
T
S
T
D
A
A
S
--
V
V
--
H
S
T
D
L
V
V
E
A
I
V
E
N
L
K
V
K
N
E
L
F
K
R
L
D
K
F
A
A
E
H
T
I
F
A
S
N
T
S
S
L
Q
I
T
S
I
A
N
A
T
T
R
Q
D
--
R
F
A
G
L
H
F
F
N
P
V
P
V
M
K
L
V
E
V
I
K
T
P
M
T
S
Q
K
T
F
E
S
L
V
D
F
S
K
-
A
L
G
K
H
P
V
S
C
K
D
T
P
G
F
I
V
S
R
L
L
V
P
Y
L
M
E
A
I
R
L
Y
E
R
G
D
A
S
K
E
D
I
D
T
A
M
K
L
G
A
G
Y
P
-
M
G
P
F
E
L
L
D
Y
V
G
L
D
T
T
K
F
I
V
D
G
W
H
E
-
M
D
A
--
E
------
N
P
L
H
Q
P
S
P
S
L
N
K
L
V
A
E
N
K
F
G
K
K
T
G
E
G
F
Y
K
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
63
HHSearch
77.45
22%
-70
- C1 -
3K6J
5
?
A:
[53-441]
-
D
V
N
S
V
A
I
I
G
G
G
T
M
G
K
A
M
A
I
C
F
G
L
A
G
I
E
T
F
L
V
V
R
----------
N
E
Q
R
-------
C
K
------
Q
E
L
E
V
M
Y
A
R
E
K
--
S
--
F
K
R
L
N
D
K
R
I
E
K
I
N
A
N
L
K
I
-----
T
S
D
F
--
H
K
L-
S
N
C
D
L
I
V
E
S
V
I
E
D
M
K
L
K
K
E
L
F
A
N
L
E
N
I
C
K
S
T
C
I
F
G
T
N
T
S
S
L
D
L
N
E
I
S
S
V
L
R
D
--
P
S
N
L
V
G
I
H
F
F
N
P
A
N
V
I
R
L
V
E
I
I
Y
G
S
H
T
S
S
Q
A
I
A
T
A
F
Q
A
C
E
-
S
I
K
K
L
P
V
L
V
G
N
C
K
S
F
V
F
N
R
L
L
H
V
Y
F
D
Q
S
Q
K
L
M
Y
E
Y
G
Y
L
P
H
Q
I
D
K
I
I
T
-
N
F
G
F
L
-
M
G
P
M
T
V
A
D
M
N
G
F
D
V
M
E
K
L
K
K
E
N
G
-----------------
L
E
P
N
P
I
E
K
E
M
W
R
L
K
R
Y
G
R
K
T
N
K
G
F
Y
K
Y
D
D
K
T
-
Q
R
K
E
N
D
--------------------------
T
E
M
E
Q
I
I
R
-----
R
V
---------------------------------
A
K
S
N
I
--
Q
I
I
----
N
D
Q
D
V
I
N
F
M
L
Y
P
T
V
N
E
G
Y
R
C
I
E
-
E
G
V
I
S
N
E
S
L
I
D
I
M
F
I
L
G
F
G
W
P
IHS
G
G
P
M
R
F
G
K
T
E
G
L
D
K
I
A
N
M
L
V
H
W
S
S
L
EPKES
A
Y
I
V
A
D
A
L
K
T
A
N----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
16
PsiBlast_PDB
77.40
31%
-77
- C1 -
1M76
3
HCDH_HUMAN
A:
[13-300]
I
I
V
K
H
V
T
V
I
G
G
G
L
M
G
A
G
I
A
Q
V
A
A
A
T
G
H
T
V
V
L
V
D
Q
----------
T
E
D
------
I
L
A
K
S
K
K
G
I
E
E
S
L
R
K
V
A
K
K
K
FAE
N
--
P
K
A
G
D
----
E
F
V
E
K
T
L
S
T
I
A
T
S
T
D
A
A
S
--
V
V
--
H
S
T
D
L
V
V
E
A
I
V
E
N
L
K
V
K
N
E
L
F
K
R
L
D
K
F
A
A
E
H
T
I
F
A
S
N
T
C
S
L
Q
I
T
S
I
A
N
A
T
T
R
Q
D
--
R
F
A
G
L
H
F
F
N
P
V
P
V
M
K
L
V
E
V
I
K
T
P
M
T
S
Q
K
T
F
E
S
L
V
D
F
S
K
-
A
L
G
K
H
P
V
S
C
K
D
T
P
G
F
I
V
N
R
L
L
V
P
Y
L
M
E
A
I
R
L
Y
E
R
G
D
A
S
K
E
D
I
D
T
A
M
K
L
G
A
G
Y
P
-
M
G
P
F
E
L
L
D
Y
V
G
L
D
T
T
K
F
I
V
D
G
W
H
E
-
M
D
A
--
E
------
N
P
L
H
Q
P
S
P
S
L
N
K
L
V
A
E
N
K
F
G
K
K
T
G
E
G
F
Y
K
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
24
PsiBlast_CBE
77.31
31%
-84
- C1 -
3HAD
1
HCDH_HUMAN
B:
[13-300]
I
I
V
K
H
V
T
V
I
G
G
G
L
M
G
A
G
I
A
Q
V
A
A
A
T
G
H
T
V
V
L
V
D
Q
----------
T
E
D
------
I
L
A
K
SKKGIE
E
S
L
R
K
V
A
K
K
K
FAE
N
--
P
K
A
G
D
----
E
F
V
E
K
T
L
S
T
IA
T
S
T
D
A
A
S
--
V
V
--
H
S
T
D
L
V
V
E
A
I
V
E
N
L
K
V
K
N
E
L
F
K
R
L
D
K
R
A
A
E
H
T
I
F
A
S
N
T
S
S
L
Q
I
T
S
I
A
N
A
T
T
R
Q
D
--
R
F
A
G
L
H
F
F
N
P
V
P
V
M
K
L
V
E
V
I
K
T
P
M
T
S
Q
K
T
F
E
S
L
V
D
F
S
K
-
A
L
G
K
H
P
V
S
C
K
D
T
P
G
F
I
V
N
R
L
L
V
P
Y
L
M
E
A
I
R
L
Y
E
R
G
D
A
S
K
E
D
I
D
T
A
M
K
L
G
A
G
Y
P
-
M
G
P
F
E
L
L
D
Y
V
G
L
D
T
T
K
F
I
V
D
G
W
H
E
-
M
D
A
--
E
------
N
P
L
H
Q
P
S
P
S
L
N
K
L
V
A
E
N
K
F
G
K
K
T
G
E
G
F
Y
K
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
7
PsiBlast_PDB
77.26
31%
-79
- C1 -
3HAD
1
HCDH_HUMAN
A:
[13-300]
I
I
V
K
H
V
T
V
I
G
G
G
L
M
G
A
G
I
A
Q
V
A
A
A
T
G
H
T
V
V
L
V
D
Q
----------
T
E
D
------
I
L
A
K
S
K
K
G
I
E
E
S
L
R
K
V
A
K
K
K
F
A
E
N
--
P
K
A
G
D
----
E
F
V
E
K
T
L
S
T
I
A
T
S
T
D
A
A
S
--
V
V
--
H
S
T
D
L
V
V
E
A
I
V
E
N
L
K
V
K
N
E
L
F
K
R
L
D
K
R
A
A
E
H
T
I
F
A
S
N
T
S
S
L
Q
I
T
S
I
A
N
A
T
T
R
Q
D
--
R
F
A
G
L
H
F
F
N
P
V
P
V
M
K
L
V
E
V
I
K
T
P
M
T
S
Q
K
T
F
E
S
L
V
D
F
S
K
-
A
L
G
K
H
P
V
S
C
K
D
T
P
G
F
I
V
N
R
L
L
V
P
Y
L
M
E
A
I
R
L
Y
E
R
G
D
A
S
K
E
D
I
D
T
A
M
K
L
G
A
G
Y
P
-
M
G
P
F
E
L
L
D
Y
V
G
L
D
T
T
K
F
I
V
D
G
W
H
E
-
M
D
A
--
E
------
N
P
L
H
Q
P
S
P
S
L
N
K
L
V
A
E
N
K
F
G
K
K
T
G
E
G
F
Y
K
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
35
PsiBlast_CBE
77.14
31%
-78
- C1 -
4KUH
1
?
B:
[1-278]
--
M
K
K
V
F
V
L
G
A
G
T
M
G
A
G
I
V
Q
A
F
A
A
K
G
C
E
V
I
V
R
D
I
KEE-------
F
V
D
R
G
I
A
-
T
I
--
T
------
K
S
L
S
K
L
V
A
K
E
---
K
--
I
T
E
A
D
----
K
E
E
I
L
S
R
I
S
--
G
T
T
D
M
K
L
--
A
A
--
D
-
C
D
L
V
V
E
A
A
I
E
N
M
K
I
K
K
E
I
F
A
E
L
D
G
I
C
K
P
E
T
I
L
A
S
N
T
S
S
L
S
I
T
E
V
A
S
A
T
K
R
A
D
--
K
V
I
G
M
H
F
F
N
P
A
P
V
M
K
L
V
E
V
I
R
G
A
A
T
S
Q
E
T
F
D
A
V
K
E
M
S
E
S
I
-
G
K
T
P
V
E
V
A
E
A
P
G
F
V
V
N
R
I
L
I
P
M
I
N
E
A
T
F
I
L
Q
E
G
V
A
K
E
E
D
I
D
A
A
M
K
L
G
A
N
H
P
-
M
G
P
L
A
L
G
D
L
I
G
L
D
V
C
L
A
I
M
D
V
L
Y
N
-
E
T
G
--
D
------
T
K
Y
-
R
A
S
S
L
L
R
K
Y
V
R
A
G
W
L
G
R
K
T
G
K
G
F
Y
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
23
PsiBlast_CBE
77.13
31%
-83
- C1 -
1F12
1
HCDH_HUMAN
B:
[13-300]
I
I
V
K
H
V
T
V
I
G
G
G
L
M
G
A
G
I
A
Q
V
A
A
A
T
G
H
T
V
V
L
V
D
Q
----------
T
E
D
------
I
L
A
K
SKKGIE
E
S
L
R
K
V
A
K
K
K
FAE
N
--
P
K
A
G
D
----
E
C
V
E
K
T
L
S
T
IA
T
S
T
D
A
A
S
--
V
V
--
H
S
T
D
L
V
V
E
A
I
V
E
N
L
K
V
K
N
E
L
F
K
R
L
D
K
F
A
A
E
H
T
I
F
A
S
N
T
S
S
L
Q
I
T
S
I
A
N
A
T
T
R
Q
D
--
R
F
A
G
L
H
F
F
N
P
V
P
V
M
K
L
V
E
V
I
K
T
P
M
T
S
Q
K
T
F
E
S
L
V
D
F
S
K
-
A
L
G
K
H
P
V
S
C
K
D
T
P
G
F
I
V
N
R
L
L
V
P
Y
L
M
E
A
I
R
L
Y
E
R
G
D
A
S
K
E
D
I
D
T
A
M
K
L
G
A
G
Y
P
-
M
G
P
F
E
L
L
D
Y
V
G
L
D
T
T
K
F
I
V
D
G
W
H
E
-
M
D
A
--
E
------
N
P
L
H
Q
P
S
P
S
L
N
K
L
V
A
E
N
K
F
G
K
K
T
G
E
G
F
Y
K
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
27
PsiBlast_CBE
77.03
31%
-79
- C1 -
4KUG
1
?
C:
[1-278]
--
M
K
K
V
F
V
L
G
A
G
T
M
G
A
G
I
V
Q
A
F
A
A
K
G
C
E
V
I
V
R
D
I
KEE-------
F
V
D
R
G
I
A
-
T
I
T
--------
K
S
L
S
K
L
V
A
K
E
---
K
--
I
T
E
A
D
----
K
E
E
I
L
S
R
I
S
--
G
T
T
D
M
K
L
--
A
A
--
D
-
C
D
L
V
V
E
A
A
I
E
N
M
K
I
K
K
E
I
F
A
E
L
D
G
I
C
K
P
E
T
I
L
A
S
N
T
S
S
L
S
I
T
E
V
A
S
A
T
K
R
A
D
--
K
V
I
G
M
H
F
F
N
P
A
P
V
M
K
L
V
E
V
I
R
G
A
A
T
S
Q
E
T
F
D
A
V
K
E
M
S
E
S
I
-
G
K
T
P
V
E
V
A
E
A
P
G
F
V
V
N
R
I
L
I
P
M
I
N
E
A
T
F
I
L
Q
E
G
V
A
K
E
E
D
I
D
A
A
M
K
L
G
A
N
H
P
-
M
G
P
L
A
L
G
D
L
I
G
L
D
V
C
L
A
I
M
D
V
L
Y
N
-
E
T
G
--
D
------
T
K
Y
-
R
A
S
S
L
L
R
K
Y
V
R
A
G
W
L
G
R
K
T
G
K
G
F
Y
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
9
PsiBlast_PDB
76.63
31%
-80
- C1 -
4KUG
1
?
A:
[1-278]
--
M
K
K
V
F
V
L
G
A
G
T
M
G
A
G
I
V
Q
A
F
A
A
K
G
C
E
V
I
V
R
D
I
K
E
E
-------
F
V
D
R
G
I
A
-
T
I
T
--------
K
S
L
S
K
L
V
A
K
E
---
K
--
I
T
E
A
D
----
K
E
E
I
L
S
R
I
S
--
G
T
T
D
M
K
L
--
A
A
--
D
-
C
D
L
V
V
E
A
A
I
E
N
M
K
I
K
K
E
I
F
A
E
L
D
G
I
C
K
P
E
T
I
L
A
S
N
T
S
S
L
S
I
T
E
V
A
S
A
T
K
R
A
D
--
K
V
I
G
M
H
F
F
N
P
A
P
V
M
K
L
V
E
V
I
R
G
A
A
T
S
Q
E
T
F
D
A
V
K
E
M
S
E
S
I
-
G
K
T
P
V
E
V
A
E
A
P
G
F
V
V
N
R
I
L
I
P
M
I
N
E
A
T
F
I
L
Q
E
G
V
A
K
E
E
D
I
D
A
A
M
K
L
G
A
N
H
P
-
M
G
P
L
A
L
G
D
L
I
G
L
D
V
C
L
A
I
M
D
V
L
Y
N
-
E
T
G
--
D
------
T
K
Y
-
R
A
S
S
L
L
R
K
Y
V
R
A
G
W
L
G
R
K
T
G
K
G
F
Y
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
28
PsiBlast_CBE
75.91
31%
-80
- C1 -
4KUG
1
?
B:
[1-278]
--
M
K
K
V
F
V
L
G
A
G
T
M
G
A
G
I
V
Q
A
F
A
A
K
G
C
E
V
I
V
R
D
I
KEE-------
F
V
D
R
G
I
A
-
T
I
T
--------
K
S
L
S
K
L
V
A
K
E
---
K
--
I
T
E
A
D
----
K
E
E
I
L
S
R
I
S
--
G
T
T
D
M
K
L
--
A
A
--
D
-
C
D
L
V
V
E
A
A
I
E
N
M
K
I
K
K
E
I
F
A
E
L
D
G
I
C
K
P
E
T
I
L
A
S
N
T
S
S
L
S
I
T
E
V
A
S
A
T
K
R
A
D
--
K
V
I
G
M
H
F
F
N
P
A
P
V
M
K
L
V
E
V
I
R
G
A
A
T
S
Q
E
T
F
D
A
V
K
E
M
S
E
S
I
-
G
K
T
P
V
E
V
A
E
A
P
G
F
V
V
N
R
I
L
I
P
M
I
N
E
A
T
F
I
L
Q
E
G
V
A
K
E
E
D
I
D
A
A
M
K
L
G
A
N
H
P
-
M
G
P
L
A
L
G
D
L
I
G
L
D
V
C
L
A
I
M
D
V
L
Y
N
-
E
T
G
--
D
------
T
K
Y
-
R
A
S
S
L
L
R
K
Y
V
R
A
G
W
L
G
R
K
T
G
K
G
F
Y
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
26
PsiBlast_CBE
75.78
31%
-77
- C1 -
4KUG
1
?
D:
[1-278]
--
M
K
K
V
F
V
L
G
A
G
T
M
G
A
G
I
V
Q
A
F
A
A
K
G
C
E
V
I
V
R
D
I
KEE-------
F
V
D
R
G
I
A
-
T
I
T
--------
K
S
L
S
K
L
V
A
K
E
---
K
--
I
T
E
A
D
----
K
E
E
I
L
S
R
I
S
--
G
T
T
D
M
K
L
--
A
A
--
D
-
C
D
L
V
V
E
A
A
I
E
N
M
K
I
K
K
E
I
F
A
E
L
D
G
I
C
K
P
E
T
I
L
A
S
N
T
S
S
L
S
I
T
E
V
A
S
A
T
K
R
A
D
--
K
V
I
G
M
H
F
F
N
P
A
P
V
M
K
L
V
E
V
I
R
G
A
A
T
S
Q
E
T
F
D
A
V
K
E
M
S
E
S
I
-
G
K
T
P
V
E
V
A
E
A
P
G
F
V
V
N
R
I
L
I
P
M
I
N
E
A
T
F
I
L
Q
E
G
V
A
K
E
E
D
I
D
A
A
M
K
L
G
A
N
H
P
-
M
G
P
L
A
L
G
D
L
I
G
L
D
V
C
L
A
I
M
D
V
L
Y
N
-
E
T
G
--
D
------
T
K
Y
-
R
A
S
S
L
L
R
K
Y
V
R
A
G
W
L
G
R
K
T
G
K
G
F
Y
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
6
PsiBlast_PDB
75.64
31%
-78
- C1 -
1F17
1
HCDH_HUMAN
A:
[13-300]
I
I
V
K
H
V
T
V
I
G
G
G
L
M
G
A
G
I
A
Q
V
A
A
A
T
G
H
T
V
V
L
V
D
Q
----------
T
E
D
------
I
L
A
K
S
K
K
G
I
E
E
S
L
R
K
V
A
K
K
K
FAE
N
--
P
K
A
G
D
----
E
C
V
E
K
T
L
S
T
I
A
T
S
T
D
A
A
S
--
V
V
--
H
S
T
D
L
V
V
E
A
I
V
E
N
L
K
V
K
N
E
L
F
K
R
L
D
K
F
A
A
E
H
T
I
F
A
S
N
T
S
S
L
Q
I
T
S
I
A
N
A
T
T
R
Q
D
--
R
F
A
G
L
H
F
F
N
P
V
P
V
M
K
L
V
E
V
I
K
T
P
M
T
S
Q
K
T
F
E
S
L
V
D
F
S
K
-
A
L
G
K
H
P
V
S
C
K
D
T
P
G
F
I
V
N
R
L
L
V
P
Y
L
M
E
A
I
R
L
Y
E
R
G
D
A
S
K
E
D
I
D
T
A
M
K
L
G
A
G
Y
P
-
M
G
P
F
E
L
L
D
Y
V
G
L
D
T
T
K
F
I
V
D
G
W
H
E
-
M
D
A
--
E
------
N
P
L
H
Q
P
S
P
S
L
N
K
L
V
A
E
N
K
F
G
K
K
T
G
E
G
F
Y
K
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
22
PsiBlast_CBE
75.37
31%
-81
- C1 -
1F17
1
HCDH_HUMAN
B:
[13-300]
I
I
V
K
H
V
T
V
I
G
G
G
L
M
G
A
G
I
A
Q
V
A
A
A
T
G
H
T
V
V
L
V
D
Q
----------
T
E
D
------
I
L
A
K
SKKGIE
E
S
L
R
K
V
A
K
K
K
FAE
N
--
P
K
A
G
D
----
E
C
V
E
K
T
L
S
T
IA
T
S
T
D
A
A
S
--
V
V
--
H
S
T
D
L
V
V
E
A
I
V
E
N
L
K
V
K
N
E
L
F
K
R
L
D
K
F
A
A
E
H
T
I
F
A
S
N
T
S
S
L
Q
I
T
S
I
A
N
A
T
T
R
Q
D
--
R
F
A
G
L
H
F
F
N
P
V
P
V
M
K
L
V
E
V
I
K
T
P
M
T
S
Q
K
T
F
E
S
L
V
D
F
S
K
-
A
L
G
K
H
P
V
S
C
K
D
T
P
G
F
I
V
N
R
L
L
V
P
Y
L
M
E
A
I
R
L
Y
E
R
G
D
A
S
K
E
D
I
D
T
A
M
K
L
G
A
G
Y
P
-
M
G
P
F
E
L
L
D
Y
V
G
L
D
T
T
K
F
I
V
D
G
W
H
E
-
M
D
A
--
E
------
N
P
L
H
Q
P
S
P
S
L
N
K
L
V
A
E
N
K
F
G
K
K
T
G
E
G
F
Y
K
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
4
PsiBlast_PDB
74.80
31%
-75
- C1 -
1F12
1
HCDH_HUMAN
A:
[13-300]
I
I
V
K
H
V
T
V
I
G
G
G
L
M
G
A
G
I
A
Q
V
A
A
A
T
G
H
T
V
V
L
V
D
Q
----------
T
E
D
------
I
L
A
K
S
K
K
G
I
E
E
S
L
R
K
V
A
K
K
K
FAE
N
--
P
K
A
G
D
----
E
C
V
E
K
T
L
S
T
I
A
T
S
T
D
A
A
S
--
V
V
--
H
S
T
D
L
V
V
E
A
I
V
E
N
L
K
V
K
N
E
L
F
K
R
L
D
K
F
A
A
E
H
T
I
F
A
S
N
T
S
S
L
Q
I
T
S
I
A
N
A
T
T
R
Q
D
--
R
F
A
G
L
H
F
F
N
P
V
P
V
M
K
L
V
E
V
I
K
T
P
M
T
S
Q
K
T
F
E
S
L
V
D
F
S
K
-
A
L
G
K
H
P
V
S
C
K
D
T
P
G
F
I
V
N
R
L
L
V
P
Y
L
M
E
A
I
R
L
Y
E
R
G
D
A
S
K
E
D
I
D
T
A
M
K
L
G
A
G
Y
P
-
M
G
P
F
E
L
L
D
Y
V
G
L
D
T
T
K
F
I
V
D
G
W
H
E
-
M
D
A
--
E
------
N
P
L
H
Q
P
S
P
S
L
N
K
L
V
A
E
N
K
F
G
K
K
T
G
E
G
F
Y
K
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
19
PsiBlast_PDB
62.96
33%
-70
- C1 -
3RQS
5
HCDH_HUMAN
A:
[124-322]
-------------------------------------------------------------------------------------------------------------------
D
L
V
V
E
A
I
V
E
N
L
K
V
K
N
E
L
F
K
R
L
D
K
F
A
A
E
H
T
I
F
A
S
N
T
S
S
L
Q
I
T
S
I
A
N
A
T
T
R
Q
D
--
R
F
A
G
L
H
F
F
N
P
V
P
V
M
K
L
V
E
V
I
K
T
P
M
T
S
Q
K
T
F
E
S
L
V
D
F
S
K
-
A
L
G
K
H
P
V
S
C
K
D
T
P
G
F
I
V
N
R
L
L
V
P
Y
L
M
E
A
I
R
L
Y
E
R
G
D
A
S
K
E
D
I
D
T
A
M
K
L
G
A
G
Y
P
-
M
G
P
F
E
L
L
D
Y
V
G
L
D
T
T
K
F
I
V
D
G
W
H
E
-
M
D
A
--
E
------
N
P
L
H
Q
P
S
P
S
L
N
K
L
V
A
E
N
K
F
G
K
K
T
G
E
G
F
Y
K
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
18
PsiBlast_PDB
61.46
33%
-70
- C1 -
2HDH
1
HCDH_HUMAN
A:
[91-289]
-------------------------------------------------------------------------------------------------------------------
D
L
V
V
E
A
I
V
E
N
L
K
V
K
N
E
L
F
K
R
L
D
K
R
A
A
E
H
T
I
F
A
S
N
T
S
S
L
Q
I
T
S
I
A
N
A
T
T
R
Q
D
--
R
F
A
G
L
H
F
F
N
P
V
P
V
M
K
L
V
E
V
I
K
T
P
M
T
S
Q
K
T
F
E
S
L
V
D
F
S
K
-
A
L
G
K
H
P
V
S
C
K
D
T
P
G
F
I
V
N
R
L
L
V
P
Y
L
M
E
A
I
R
L
Y
E
R
G
D
A
S
K
E
D
I
D
T
A
M
K
L
G
A
G
Y
P
-
M
G
P
F
E
L
L
D
Y
V
G
L
D
T
T
K
F
I
V
D
G
W
H
E
-
M
D
A
--
E
------
N
P
L
H
Q
P
S
P
S
L
N
K
L
V
A
E
N
K
F
G
K
K
T
G
E
G
F
Y
K
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------