@TOME V2.3
(Nov 2016)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : SA0347: (2016-03-14 )
MKDTQLAQITLTDDSTGAIANPIHLSTAYKHPKLGQSTGFDYTRTKNPTRSTFETCFAKLEHGIASFATSSGMSAIQLICNLFKPHDEILVSFDLYGGTFRLFEFYEQQYDIKFKYVDFTDYEQVEKEITDKTVALFIEPISNPQMIAIDVKPYYQLCKAKGLLSIIDNTFLTPYLSTPLAEGADIVLHSATKYIGGHNDVLAGVVTVKDESLAQQLFDFHNMTGATLSPIDSYLLLRGLKTLHLRIERAQSNARKLAKKCQSLQAIDEVLYSGQTGMLSLRLNKAYSVAKLLENLDICIFAESLGGTETLVTFPYTQTHVDMPDAEKDKRGIDEYLIRLSLGVENYEDIERDIIQALDKAQIGEIV
Atome Classification :
(36 SA)
.........10-------...--.....20........30...--------.--------..--------.----.40........50........60........70......-.-.80..-......90........100.......-110.......120........130.......140.......150-.......----160-.-.......170..-.....180.......190.......200.-......210-...-.------.--------------------------.-.--220.........230.......240.......250.......260.......270-----------------.----------------.-----------------.----------------.----------------...280...-.-...290-.-.......300.......310.......320.......330.......340.......350.......360.....
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MKDT
Q
L
A
Q
I
T
L-------TDD--STGAIAN
P
I
H
L
STAYKHPKL--------G--------QS--------T----GFDYTRTKNP
T
R
S
T
F
E
T
C
F
A
K
L
E
H
G
I
A
S
F
A
TSS
G
M
S
A
I
Q
-
L
-
I
C
N
LF-KPH
D
E
I
L
V
S
F
DLYGG
T
F
R
L
F
E
F
Y
E
QQ-Y
D
I
K
F
K
Y
VDFT-
D
Y
E
Q
V
E
K
E
ITD
K
T
V
A
L
F
I
E
PISNP
Q
M
I
A
I
D
V
K
-
P
Y
Y
Q
L
C
K
----A-K-
G
-
L
L
S
I
I
DNTFLTP-YLSTPLAEGA
D
I
V
L
HS
A
T
K
YIGGHN
D
V
L
A
-
G
V
V
T
VK
D
E
S
-
L
A
Q
-
Q
------
L
--------------------------
F
-
D
--
F
--HNMTGA
T
L
S
P
I
D
S
Y
L
L
L
R
G
L
K
T
L
H
L
R
I
E
R
A
Q
S
N
A
R
K
L
A
K
K
C
Q
S
L
Q
A
I
D
E
V
L
Y-----------------S----------------G-----------------Q----------------T----------------
G
M
L
S
L
R
LN
K
-
A
-
Y
S
V
A
-
K
-
L
-
L
E
NL
D
I
C
I
F
A
E
SLGGT
E
T
L
V
T
FPYTQTHVDMPD
A
E
K
D
KR
G
I
D
E
Y
L
I
R
L
SLGVE
N
Y
E
D
I
E
R
D
I
I
Q
A
L
D
K
A
QIGEIV
102
HHSearch
90.58
38%
-95
- C1 -
3COG
5
CGL_HUMAN
A:
[19-400]
-
F
A
T
Q
A
I
H
V
G
Q
-------
D
P
E
QW
T
S
R
A
V
V
P
P
I
S
L
S
T
T
F
K
Q
------------------------------------------
G
N
P
T
R
N
C
L
E
K
A
V
A
A
L
D
G
A
K
Y
C
L
A
F
A
S
G
L
A
A
T
V
T
I
-
T
-
H
L
L
-
K
A
G
D
Q
I
I
C
M
D
D
V
Y
G
G
T
N
R
Y
F
R
Q
V
A
S
E
-
F
G
L
K
I
S
F
V
D
C
S
-
K
I
K
L
L
E
A
A
I
T
P
E
T
K
L
V
W
I
E
T
P
T
N
P
T
Q
K
V
I
D
I
E
-
G
C
A
H
I
V
H
----
K
-
H
G
D
-
I
I
L
V
V
D
N
T
F
M
S
P
-
Y
F
Q
R
P
L
A
L
G
A
D
I
S
M
Y
S
A
T
K
Y
M
N
G
H
S
D
V
V
M
-
G
L
V
S
V
N
C
E
S
-
L
H
N
-
R
------
L
--------------------------
R
-
F
--
L
--
Q
N
S
L
G
A
V
P
S
P
I
D
C
Y
L
C
N
R
G
L
K
T
L
H
V
R
M
E
K
H
F
K
N
G
M
A
V
A
Q
F
L
E
S
N
P
W
V
E
K
V
I
Y
-----------------
P
GLPSHPQ
H
E
L
V
K
R
Q
C
T
G
-----------------
C
----------------
T
----------------
G
M
V
T
F
Y
I
K
G
-
T
L
Q
H
A
E
-
I
-
F
-
L
K
N
L
K
L
F
T
L
A
E
S
L
G
G
F
E
S
L
A
E
L
P
A
I
M
T
H
A
S
V
L
K
N
D
R
D
V
L
G
I
S
D
T
L
I
R
L
S
V
G
L
E
D
E
E
D
L
L
E
D
L
D
Q
A
L
K
A
A
H
P
----
122
Fugue
90.47
37%
-96
- C1 -
1CS1
-
METB_ECOLI
A:
[3-386]
---
R
K
Q
A
T
I
A
V
RSGLNDD
E
Q
Y
----
G
C
V
V
P
P
I
H
L
S
S
T
Y
N
F
T
G
F
----------------------------NEPR
A
H
D
Y
S
R
R
G
N
P
T
R
D
V
V
Q
R
A
L
A
E
L
E
G
G
A
G
A
V
L
T
N
T
G
M
S
A
I
H
-
L
-
V
T
T
V
F
L
K
P
G
D
L
L
V
A
P
H
D
C
Y
G
G
S
Y
R
L
F
D
S
L
A
K
R
-
G
C
Y
R
V
L
F
V
D
Q
G
-
D
E
Q
A
L
R
A
A
L
A
E
K
P
K
L
V
L
V
E
S
P
S
N
P
L
L
R
V
V
D
I
A
-
K
I
C
H
L
A
R
----
E
-
V
-
G
-
A
V
S
V
V
D
N
T
F
L
S
P
-
A
L
Q
N
P
L
A
L
G
A
D
L
V
L
H
S
C
T
K
Y
L
N
G
H
S
D
V
V
A
-
G
V
V
I
A
K
D
P
D
-
V
V
T
-
E
------
L
--------------------------
A
-
W
--
W
--
A
N
N
I
G
V
T
G
G
A
F
D
S
Y
L
L
L
R
G
L
R
T
L
V
P
R
M
E
L
A
Q
R
N
A
Q
A
I
V
K
Y
L
Q
T
Q
P
L
V
K
K
L
Y
H
-----------------
P
----------------
S
-----------------
L
----------------
P
ENQ
G
H
E
I
A
A
RQQKGFG
A
M
L
S
F
E
L
D
G
D
E
-
Q
T
L
R
-
R
-
F
-
L
G
G
L
S
L
F
T
L
A
E
S
L
G
G
V
E
S
L
I
S
H
A
A
T
M
T
H
A
G
M
A
P
E
A
R
A
A
A
G
I
S
E
T
L
L
R
I
S
T
G
I
E
D
G
E
D
L
I
A
D
L
E
N
G
F
R
A
A
N
K
G
---
28
PsiBlast_CBE
90.29
38%
-99
- C1 -
4IY7
5
?
D:
[29-393]
-------------------
D
P
--
S
T
G
A
V
M
P
P
I
Y
A
T
S
T
Y
A
Q
S
S
P
--------
G
--------
E
H
--------
Q
----
G
F
E
Y
S
R
T
H
N
P
T
R
F
A
Y
E
R
C
V
A
A
L
E
G
G
T
R
A
F
A
F
A
S
G
M
A
A
T
S
-
T
-
V
M
E
L
L
-
D
A
G
S
H
V
V
A
M
D
D
L
Y
G
G
T
F
R
L
F
E
R
V
R
R
R
T
A
G
L
D
F
S
F
V
D
L
T
-
D
P
A
A
F
K
A
A
I
R
A
D
T
K
M
V
W
I
E
T
P
T
N
P
M
L
K
L
V
D
I
A
-
A
I
A
V
I
A
R
----
K
-
H
-
G
-
L
L
T
V
V
D
N
T
F
A
S
P
-
M
L
Q
R
P
L
S
L
G
A
D
L
V
V
H
S
A
T
K
Y
L
N
G
H
S
D
M
V
G
-
G
I
A
V
V
G
D
N
A
E
L
A
E
-
Q
------
M
--------------------------
A
-
F
--
L
--
Q
N
S
I
G
G
V
Q
G
P
F
D
S
F
L
A
L
R
G
L
K
T
L
P
L
R
M
R
A
H
C
E
N
A
L
A
L
A
Q
W
L
E
T
H
P
A
I
E
K
V
I
Y
PGLASHPQHVLAKRQM-
S
----------------
G
-----------------
F
----------------
G
----------------
G
I
V
S
I
V
L
K
G
-
G
-
F
D
A
A
-
K
R
F
-
C
E
K
T
E
L
F
T
L
A
E
S
L
G
G
V
E
S
L
V
N
H
P
A
V
M
T
H
A
S
I
P
V
A
R
R
E
Q
L
G
I
S
D
A
L
V
R
L
S
V
G
I
E
D
L
G
D
L
R
G
D
L
E
R
A
L
---------
30
PsiBlast_CBE
90.03
38%
-99
- C1 -
4IY7
6
?
B:
[29-393]
-------------------
D
P
--
S
T
G
A
V
M
P
P
I
Y
A
T
S
T
Y
A
Q
S
S
P
--------
G
--------
E
H
--------
Q
----
G
F
E
Y
S
R
T
H
N
P
T
R
F
A
Y
E
R
C
V
A
A
L
E
G
G
T
R
A
F
A
F
A
S
G
M
A
A
T
S
-
T
-
V
M
E
L
L
-
D
A
G
S
H
V
V
A
M
D
D
L
Y
G
G
T
F
R
L
F
E
R
V
R
R
R
T
A
G
L
D
F
S
F
V
D
L
T
-
D
P
A
A
F
K
A
A
I
R
A
D
T
K
M
V
W
I
E
T
P
T
N
P
M
L
K
L
V
D
I
A
-
A
I
A
V
I
A
R
----
K
-
H
-
G
-
L
L
T
V
V
D
N
T
F
A
S
P
-
M
L
Q
R
P
L
S
L
G
A
D
L
V
V
H
S
A
T
K
Y
L
N
G
H
S
D
M
V
G
-
G
I
A
V
V
G
D
N
A
E
L
A
E
-
Q
------
M
--------------------------
A
-
F
--
L
--
Q
N
S
I
G
G
V
Q
G
P
F
D
S
F
L
A
L
R
G
L
K
T
L
P
L
R
M
R
A
H
C
E
N
A
L
A
L
A
Q
W
L
E
T
H
P
A
I
E
K
V
I
Y
PGLASHPQHVLAKRQM-
S
----------------
G
-----------------
F
----------------
G
----------------
G
I
V
S
I
V
L
K
G
-
G
-
F
D
A
A
-
K
R
F
-
C
E
K
T
E
L
F
T
L
A
E
S
L
G
G
V
E
S
L
V
N
H
P
A
V
M
T
H
A
S
I
P
V
A
R
R
E
Q
L
G
I
S
D
A
L
V
R
L
S
V
G
I
E
D
L
G
D
L
R
G
D
L
E
R
A
L
---------
3
PsiBlast_PDB
89.66
38%
-99
- C1 -
4IYO
8
?
A:
[29-393]
-------------------
D
P
--
S
T
G
A
V
M
P
P
I
Y
A
T
S
T
Y
A
Q
S
S
P
--------
G
--------
E
H
--------
Q
----
G
F
E
Y
S
R
T
H
N
P
T
R
F
A
Y
E
R
C
V
A
A
L
E
G
G
T
R
A
F
A
F
A
S
G
M
A
A
T
S
-
T
-
V
M
E
L
L
-
D
A
G
S
H
V
V
A
M
D
D
L
Y
G
G
T
F
R
L
F
E
R
V
R
R
R
T
A
G
L
D
F
S
F
V
D
L
T
-
D
P
A
A
F
K
A
A
I
R
A
D
T
K
M
V
W
I
E
T
P
T
N
P
M
L
K
L
V
D
I
A
-
A
I
A
V
I
A
R
----
K
-
H
-
G
-
L
L
T
V
V
D
N
T
F
A
S
P
-
M
L
Q
R
P
L
S
L
G
A
D
L
V
V
H
S
A
T
K
Y
L
N
G
H
S
D
M
V
G
-
G
I
A
V
V
G
D
N
A
E
L
A
E
-
Q
------
M
--------------------------
A
-
F
--
L
--
Q
N
S
I
G
G
V
Q
G
P
F
D
S
F
L
A
L
R
G
L
K
T
L
P
L
R
M
R
A
H
C
E
N
A
L
A
L
A
Q
W
L
E
T
H
P
A
I
E
K
V
I
Y
PGLASHPQ
H
V
L
A
K
R
Q
M
-
S
----------------
G
-----------------
F
----------------
G
----------------
G
I
V
S
I
V
L
K
G
-
G
-
F
D
A
A
-
K
R
F
-
C
E
K
T
E
L
F
T
L
A
E
S
L
G
G
V
E
S
L
V
N
H
P
A
V
M
T
H
A
S
I
P
V
A
R
R
E
Q
L
G
I
S
D
A
L
V
R
L
S
V
G
I
E
D
L
G
D
L
R
G
D
L
E
R
A
L
---------
26
PsiBlast_CBE
89.48
39%
-102
- C1 -
4L0O
2
METB_HELPY
C:
[15-378]
-------------------
D
A
--
T
T
G
A
V
S
V
P
I
Y
Q
T
S
T
Y
R
Q
D
A
I
--------
G
-----------------------
G
Y
E
Y
S
R
S
G
N
P
T
R
F
A
L
E
E
L
I
A
D
L
E
G
G
V
K
G
F
A
F
A
S
G
L
A
G
I
H
-
A
-
V
F
S
L
L
-
Q
S
G
D
H
V
L
L
G
D
D
V
Y
G
G
T
F
R
L
F
N
Q
V
L
V
K
-
N
G
L
S
C
T
I
I
D
T
S
-
D
I
S
Q
I
K
K
A
I
K
P
N
T
K
A
L
Y
L
E
T
P
S
N
P
L
L
K
I
T
D
L
A
-
Q
C
A
S
V
A
K
----
D
-
H
-
G
-
L
L
T
I
V
D
N
T
F
A
T
P
-
Y
Y
Q
N
P
L
L
L
G
A
D
I
V
A
H
S
G
T
K
Y
L
G
G
H
S
D
V
V
A
-
G
L
V
T
T
N
N
E
A
-
L
A
Q
-
E
------
I
--------------------------
A
-
F
--
F
--
Q
N
A
I
G
G
V
L
G
P
Q
D
S
W
L
L
Q
R
G
I
K
T
L
G
L
R
M
E
A
H
Q
K
N
A
L
C
V
A
E
F
L
E
K
H
P
K
V
E
R
V
Y
Y
-----------------
P
----------------
G
-----------------
L
PT
H
P
N
Y
E
L
A
KKQMRG
F
S
----------------
G
M
L
S
F
T
L
K
N
-
D
-
S
E
A
V
-
A
-
F
-
V
E
S
L
K
L
F
I
L
G
E
S
L
G
G
V
E
S
L
V
G
I
P
A
F
M
T
H
----------
A
G
I
R
D
G
L
V
R
L
S
V
G
I
E
H
E
Q
D
L
L
E
D
L
E
Q
A
F
A
K
-------
29
PsiBlast_CBE
89.28
38%
-99
- C1 -
4IY7
4
?
C:
[29-393]
-------------------
D
P
--
S
T
G
A
V
M
P
P
I
Y
A
T
S
T
Y
A
Q
S
S
P
--------
G
--------
E
H
--------
Q
----
G
F
E
Y
S
R
T
H
N
P
T
R
F
A
Y
E
R
C
V
A
A
L
E
G
G
T
R
A
F
A
F
A
S
G
M
A
A
T
S
-
T
-
V
M
E
L
L
-
D
A
G
S
H
V
V
A
M
D
D
L
Y
G
G
T
F
R
L
F
E
R
V
R
R
R
T
A
G
L
D
F
S
F
V
D
L
T
-
D
P
A
A
F
K
A
A
I
R
A
D
T
K
M
V
W
I
E
T
P
T
N
P
M
L
K
L
V
D
I
A
-
A
I
A
V
I
A
R
----
K
-
H
-
G
-
L
L
T
V
V
D
N
T
F
A
S
P
-
M
L
Q
R
P
L
S
L
G
A
D
L
V
V
H
S
A
T
K
Y
L
N
G
H
S
D
M
V
G
-
G
I
A
V
V
G
D
N
A
E
L
A
E
-
Q
------
M
--------------------------
A
-
F
--
L
--
Q
N
S
I
G
G
V
Q
G
P
F
D
S
F
L
A
L
R
G
L
K
T
L
P
L
R
M
R
A
H
C
E
N
A
L
A
L
A
Q
W
L
E
T
H
P
A
I
E
K
V
I
Y
PGLASHPQHVLAKRQM-
S
----------------
G
-----------------
F
----------------
G
----------------
G
I
V
S
I
V
L
K
G
-
G
-
F
D
A
A
-
K
R
F
-
C
E
K
T
E
L
F
T
L
A
E
S
L
G
G
V
E
S
L
V
N
H
P
A
V
M
T
H
A
S
I
P
V
A
R
R
E
Q
L
G
I
S
D
A
L
V
R
L
S
V
G
I
E
D
L
G
D
L
R
G
D
L
E
R
A
L
---------
104
HHSearch
88.77
37%
-88
- C1 -
1CS1
-
METB_ECOLI
A:
[5-385]
-
Q
A
T
I
A
V
R
S
G
L
-------
N
D
D
E-
Q
Y
G
C
V
V
P
P
I
H
L
S
S
T
Y
N
F
T
G
F
--------
N
--------
E
P
--------
R
----
A
H
D
Y
S
R
R
G
N
P
T
R
D
V
V
Q
R
A
L
A
E
L
E
G
G
A
G
A
V
L
T
N
T
G
M
S
A
I
H
L
V
-
T
T
V
F
L
-
K
P
G
D
L
L
V
A
P
H
D
C
Y
G
G
S
Y
R
L
F
D
S
L
A
K
R
-
G
C
Y
R
V
L
F
V
D
Q
G
-
D
E
Q
A
L
R
A
A
L
A
E
K
P
K
L
V
L
V
E
S
P
S
N
P
L
L
R
V
V
D
I
A
-
K
I
C
H
L
A
R
----
E
-
V
-
G
-
A
V
S
V
V
D
N
T
F
L
S
P
-
A
L
Q
N
P
L
A
L
G
A
D
L
V
L
H
S
C
T
K
Y
L
N
G
H
S
D
V
V
A
-
G
V
V
I
A
K
D
P
D
-
V
V
T
-
E
------
L
--------------------------
A
-
W
--
W
--
A
N
N
I
G
V
T
G
G
A
F
D
S
Y
L
L
L
R
G
L
R
T
L
V
P
R
M
E
L
A
Q
R
N
A
Q
A
I
V
K
Y
L
Q
T
Q
P
L
V
K
K
L
Y
H
-----------------
P
SLPENQ
G
H
E
I
A
A
RQQK
G
-----------------
F
----------------
G
----------------
A
M
L
S
F
E
L
D
G
-
D
E
Q
T
L
R
-
R
-
F
-
L
G
G
L
S
L
F
T
L
A
E
S
L
G
G
V
E
S
L
I
S
H
A
A
T
M
T
H
A
G
M
A
P
E
A
R
A
A
A
G
I
S
E
T
L
L
R
I
S
T
G
I
E
D
G
E
D
L
I
A
D
L
E
N
G
F
R
A
A
N
K
----
5
PsiBlast_PDB
88.73
36%
-91
- C1 -
1CS1
-
METB_ECOLI
A:
[17-386]
-------------------
D
E
--
Q
Y
G
C
V
V
P
P
I
H
L
S
S
T
Y
N
F
T
G
F
--------
N
--------
E
P
--------
R
----
A
H
D
Y
S
R
R
G
N
P
T
R
D
V
V
Q
R
A
L
A
E
L
E
G
G
A
G
A
V
L
T
N
T
G
M
S
A
I
H
-
L
-
V
T
T
V
F
L
K
P
G
D
L
L
V
A
P
H
D
C
Y
G
G
S
Y
R
L
F
D
S
L
A
K
R
-
G
C
Y
R
V
L
F
V
D
Q
G
-
D
E
Q
A
L
R
A
A
L
A
E
K
P
K
L
V
L
V
E
S
P
S
N
P
L
L
R
V
V
D
I
A
-
K
I
C
H
L
A
R
----
E
-
V
-
G
-
A
V
S
V
V
D
N
T
F
L
S
P
-
A
L
Q
N
P
L
A
L
G
A
D
L
V
L
H
S
C
T
K
Y
L
N
G
H
S
D
V
V
A
-
G
V
V
I
A
K
D
P
D
-
V
V
T
-
E
------
L
--------------------------
A
-
W
--
W
--
A
N
N
I
G
V
T
G
G
A
F
D
S
Y
L
L
L
R
G
L
R
T
L
V
P
R
M
E
L
A
Q
R
N
A
Q
A
I
V
K
Y
L
Q
T
-
Q
P
L
V
K
K
L
Y
HPSLPENQ
G
H
E
I
A
A
RQQ
K
----------------
G
-----------------
F
----------------
G
----------------
A
M
L
S
F
E
L
D
G
D
E
-
Q
T
L
R
-
R
-
F
-
L
G
G
L
S
L
F
T
L
A
E
S
L
G
G
V
E
S
L
I
S
H
A
A
T
M
T
H
A
G
M
A
P
E
A
R
A
A
A
G
I
S
E
T
L
L
R
I
S
T
G
I
E
D
G
E
D
L
I
A
D
L
E
N
G
F
R
A
A
N
K
G
---
32
PsiBlast_CBE
88.58
38%
-96
- C1 -
3COG
8
CGL_HUMAN
D:
[37-399]
--------------------------
A
V
V
P
P
I
S
L
S
T
T
F
K
Q
G
A
P
--------
G
--------
Q
H
--------
S
----
G
F
E
Y
S
R
S
G
N
P
T
R
N
C
L
E
K
A
V
A
A
L
D
G
A
K
Y
C
L
A
F
A
S
G
L
A
A
T
V
-
T
-
I
T
H
L
L
-
K
A
G
D
Q
I
I
C
M
D
D
V
Y
G
G
T
N
R
Y
F
R
Q
V
A
S
E
-
F
G
L
K
I
S
F
V
D
C
S
-
K
I
K
L
L
E
A
A
I
T
P
E
T
K
L
V
W
I
E
T
P
T
N
P
T
Q
K
V
I
D
I
E
-
G
C
A
H
I
V
H
----
K
-
H
-
G
D
I
I
L
V
V
D
N
T
F
M
S
P
-
Y
F
Q
R
P
L
A
L
G
A
D
I
S
M
Y
S
A
T
K
Y
M
N
G
H
S
D
V
V
M
-
G
L
V
S
V
N
C
E
S
-
L
H
N
-
R
------
L
--------------------------
R
-
F
--
L
--
Q
N
S
L
G
A
V
P
S
P
I
D
C
Y
L
C
N
R
G
L
K
T
L
H
V
R
M
E
K
H
F
K
N
G
M
A
V
A
Q
F
L
E
S
N
P
W
V
E
K
V
I
Y
PGLPSHPQHELVKRQC-
T
----------------
G
-----------------
C
----------------
T
----------------
G
M
V
T
F
Y
I
K
G
-
T
-
L
Q
H
A
-
E
-
I
F
L
K
N
L
K
L
F
T
L
A
E
S
L
G
G
F
E
S
L
A
E
L
P
A
I
M
T
H
A
S
V
L
K
N
D
R
D
V
L
G
I
S
D
T
L
I
R
L
S
V
G
L
E
D
E
E
D
L
L
E
D
L
D
Q
A
L
K
A
A
H
-----
2
PsiBlast_PDB
88.44
38%
-97
- C1 -
4IY7
8
?
A:
[29-393]
-------------------
D
P
--
S
T
G
A
V
M
P
P
I
Y
A
T
S
T
Y
A
Q
S
S
P
--------
G
--------
E
H
--------
Q
----
G
F
E
Y
S
R
T
H
N
P
T
R
F
A
Y
E
R
C
V
A
A
L
E
G
G
T
R
A
F
A
F
A
S
G
M
A
A
T
S
-
T
-
V
M
E
L
L
-
D
A
G
S
H
V
V
A
M
D
D
L
Y
G
G
T
F
R
L
F
E
R
V
R
R
R
T
A
G
L
D
F
S
F
V
D
L
T
-
D
P
A
A
F
K
A
A
I
R
A
D
T
K
M
V
W
I
E
T
P
T
N
P
M
L
K
L
V
D
I
A
-
A
I
A
V
I
A
R
----
K
-
H
-
G
-
L
L
T
V
V
D
N
T
F
A
S
P
-
M
L
Q
R
P
L
S
L
G
A
D
L
V
V
H
S
A
T
K
Y
L
N
G
H
S
D
M
V
G
-
G
I
A
V
V
G
D
N
A
E
L
A
E
-
Q
------
M
--------------------------
A
-
F
--
L
--
Q
N
S
I
G
G
V
Q
G
P
F
D
S
F
L
A
L
R
G
L
K
T
L
P
L
R
M
R
A
H
C
E
N
A
L
A
L
A
Q
W
L
E
T
H
P
A
I
E
K
V
I
Y
PGLASHPQ
H
V
L
A
K
R
Q
M
-
S
----------------
G
-----------------
F
----------------
G
----------------
G
I
V
S
I
V
L
K
G
-
G
-
F
D
A
A
-
K
R
F
-
C
E
K
T
E
L
F
T
L
A
E
S
L
G
G
V
E
S
L
V
N
H
P
A
V
M
T
H
A
S
I
P
V
A
R
R
E
Q
L
G
I
S
D
A
L
V
R
L
S
V
G
I
E
D
L
G
D
L
R
G
D
L
E
R
A
L
---------
23
PsiBlast_CBE
88.19
39%
-99
- C1 -
4L0O
1
METB_HELPY
K:
[15-378]
-------------------
D
A
--
T
T
G
A
V
S
V
P
I
Y
Q
T
S
T
Y
R
Q
D
A
I
--------
G
--------
R
H
-------------
G
Y
E
Y
S
R
S
G
N
P
T
R
F
A
L
E
E
L
I
A
D
L
E
G
G
V
K
G
F
A
F
A
S
G
L
A
G
I
H
-
A
-
V
F
S
L
L
-
Q
S
G
D
H
V
L
L
G
D
D
V
Y
G
G
T
F
R
L
F
N
Q
V
L
V
K
-
N
G
L
S
C
T
I
I
D
T
S
-
D
I
S
Q
I
K
K
A
I
K
P
N
T
K
A
L
Y
L
E
T
P
S
N
P
L
L
K
I
T
D
L
A
-
Q
C
A
S
V
A
K
----
D
-
H
-
G
-
L
L
T
I
V
D
N
T
F
A
T
P
-
Y
Y
Q
N
P
L
L
L
G
A
D
I
V
A
H
S
G
T
K
Y
L
G
G
H
S
D
V
V
A
-
G
L
V
T
T
N
N
E
A
-
L
A
Q
-
E
------
I
--------------------------
A
-
F
--
F
--
Q
N
A
I
G
G
V
L
G
P
Q
D
S
W
L
L
Q
R
G
I
K
T
L
G
L
R
M
E
A
H
Q
K
N
A
L
C
V
A
E
F
L
E
K
H
P
K
V
E
R
V
Y
Y
-----------------
P
----------------
G
-----------------
L
PTHPNYELAKKQMRGF
S
----------------
G
M
L
S
F
T
L
K
N
-
D
-
S
E
A
V
-
A
-
F
-
V
E
S
L
K
L
F
I
L
G
E
S
L
G
G
V
E
S
L
V
G
I
P
A
F
M
T
H
A
C
I
P
K
T
Q
R
E
A
A
G
I
R
D
G
L
V
R
L
S
V
G
I
E
H
E
Q
D
L
L
E
D
L
E
Q
A
F
A
K
-------
31
PsiBlast_CBE
87.94
36%
-93
- C1 -
1CS1
1
METB_ECOLI
D:
[17-386]
-------------------
D
E
--
Q
Y
G
C
V
V
P
P
I
H
L
S
S
T
Y
N
F
T
G
F
--------
N
--------
E
P
--------
R
----
A
H
D
Y
S
R
R
G
N
P
T
R
D
V
V
Q
R
A
L
A
E
L
E
G
G
A
G
A
V
L
T
N
T
G
M
S
A
I
H
-
L
-
V
T
T
V
F
L
K
P
G
D
L
L
V
A
P
H
D
C
Y
G
G
S
Y
R
L
F
D
S
L
A
K
R
-
G
C
Y
R
V
L
F
V
D
Q
G
-
D
E
Q
A
L
R
A
A
L
A
E
K
P
K
L
V
L
V
E
S
P
S
N
P
L
L
R
V
V
D
I
A
-
K
I
C
H
L
A
R
----
E
-
V
-
G
-
A
V
S
V
V
D
N
T
F
L
S
P
-
A
L
Q
N
P
L
A
L
G
A
D
L
V
L
H
S
C
T
K
Y
L
N
G
H
S
D
V
V
A
-
G
V
V
I
A
K
D
P
D
-
V
V
T
-
E
------
L
--------------------------
A
-
W
--
W
--
A
N
N
I
G
V
T
G
G
A
F
D
S
Y
L
L
L
R
G
L
R
T
L
V
P
R
M
E
L
A
Q
R
N
A
Q
A
I
V
K
Y
L
Q
T
-
Q
P
L
V
K
K
L
Y
HPSLPENQGHEIAARQQ
K
----------------
G
-----------------
F
----------------
G
----------------
A
M
L
S
F
E
L
D
G
D
E
-
Q
T
L
R
-
R
-
F
-
L
G
G
L
S
L
F
T
L
A
E
S
L
G
G
V
E
S
L
I
S
H
A
A
T
M
T
H
A
G
M
A
P
E
A
R
A
A
A
G
I
S
E
T
L
L
R
I
S
T
G
I
E
D
G
E
D
L
I
A
D
L
E
N
G
F
R
A
A
N
K
G
---
1
PsiBlast_PDB
87.50
39%
-101
- C1 -
4L0O
2
METB_HELPY
H:
[15-378]
-------------------
D
A
--
T
T
G
A
V
S
V
P
I
Y
Q
T
S
T
Y
R
Q
D
----------------------------------
G
Y
E
Y
S
R
S
G
N
P
T
R
F
A
L
E
E
L
I
A
D
L
E
G
G
V
K
G
F
A
F
A
S
G
L
A
G
I
H
-
A
-
V
F
S
L
L
-
Q
S
G
D
H
V
L
L
G
D
D
V
Y
G
G
T
F
R
L
F
N
Q
V
L
V
K
-
N
G
L
S
C
T
I
I
D
T
S
-
D
I
S
Q
I
K
K
A
I
K
P
N
T
K
A
L
Y
L
E
T
P
S
N
P
L
L
K
I
T
D
L
A
-
Q
C
A
S
V
A
K
----
D
-
H
-
G
-
L
L
T
I
V
D
N
T
F
A
T
P
-
Y
Y
Q
N
P
L
L
L
G
A
D
I
V
A
H
S
G
T
K
Y
L
G
G
H
S
D
V
V
A
-
G
L
V
T
T
N
N
E
A
-
L
A
Q
-
E
------
I
--------------------------
A
-
F
--
F
--
Q
N
A
I
G
G
V
L
G
P
Q
D
S
W
L
L
Q
R
G
I
K
T
L
G
L
R
M
E
A
H
Q
K
N
A
L
C
V
A
E
F
L
E
K
H
P
K
V
E
R
V
Y
Y
-----------------
P
----------------
G
-----------------
L
PTHPNYELAKKQMRGF
S
----------------
G
M
L
S
F
T
L
K
N
-
D
-
S
E
A
V
-
A
-
F
-
V
E
S
L
K
L
F
I
L
G
E
S
L
G
G
V
E
S
L
V
G
I
P
A
F
M
T
H
A
C
I
P
K
T
Q
R
E
A
A
G
I
R
D
G
L
V
R
L
S
V
G
I
E
H
E
Q
D
L
L
E
D
L
E
Q
A
F
A
K
-------
33
PsiBlast_CBE
86.80
38%
-96
- C1 -
3COG
8
CGL_HUMAN
C:
[37-399]
--------------------------
A
V
V
P
P
I
S
L
S
T
T
F
K
Q
G
A
P
--------
G
--------
Q
--------------
G
F
E
Y
S
R
S
G
N
P
T
R
N
C
L
E
K
A
V
A
A
L
D
G
A
K
Y
C
L
A
F
A
S
G
L
A
A
T
V
-
T
-
I
T
H
L
L
-
K
A
G
D
Q
I
I
C
M
D
D
V
Y
G
G
T
N
R
Y
F
R
Q
V
A
S
E
-
F
G
L
K
I
S
F
V
D
C
S
-
K
I
K
L
L
E
A
A
I
T
P
E
T
K
L
V
W
I
E
T
P
T
N
P
T
Q
K
V
I
D
I
E
-
G
C
A
H
I
V
H
----
K
-
H
-
G
D
I
I
L
V
V
D
N
T
F
M
S
P
-
Y
F
Q
R
P
L
A
L
G
A
D
I
S
M
Y
S
A
T
K
Y
M
N
G
H
S
D
V
V
M
-
G
L
V
S
V
N
C
E
S
-
L
H
N
-
R
------
L
--------------------------
R
-
F
--
L
--
Q
N
S
L
G
A
V
P
S
P
I
D
C
Y
L
C
N
R
G
L
K
T
L
H
V
R
M
E
K
H
F
K
N
G
M
A
V
A
Q
F
L
E
S
N
P
W
V
E
K
V
I
Y
PGLPSHPQ
H
E
L
V
K
R
Q
C
-
T
----------------
G
-----------------
C
----------------
T
----------------
G
M
V
T
F
Y
I
K
G
-
T
-
L
Q
H
A
-
E
-
I
F
L
K
N
L
K
L
F
T
L
A
E
S
L
G
G
F
E
S
L
A
E
L
P
A
I
M
T
H
A
S
V
L
K
N
D
R
D
V
L
G
I
S
D
T
L
I
R
L
S
V
G
L
E
D
E
E
D
L
L
E
D
L
D
Q
A
L
K
A
A
H
-----
115
HHSearch
86.58
37%
-108
* C1 *
1PFF
18
?
A:
[2-330]
----------------------------------------------------------------------------------------
A
L
E
G
K
I
A
K
L
E
H
A
E
A
C
A
A
T
A
S
G
M
G
A
I
A
A
S
-
V
W
T
F
L
-
K
A
G
D
H
L
I
S
D
D
C
L
Y
G
C
T
H
A
L
F
E
H
Q
L
R
K
-
F
G
V
E
V
D
F
I
D
M
A
-
V
P
G
N
I
E
K
H
L
K
P
N
T
R
I
V
Y
F
E
T
P
A
N
P
T
L
K
V
I
D
I
E
-
D
A
V
K
Q
A
R
----
K
Q
K
-
D
-
I
L
V
I
V
D
N
T
F
A
S
P
-
I
L
T
N
P
L
D
L
G
V
D
I
V
V
H
S
A
T
K
Y
I
N
G
H
T
D
V
V
A
-
G
L
V
C
S
R
A
D
--
I
I
A
-
K
------
V
--------------------------
K
-
S
--
Q
GI
K
D
I
T
G
A
I
I
S
P
H
D
A
W
L
I
T
R
G
T
L
T
L
D
M
R
V
K
R
A
A
E
N
A
Q
K
V
A
E
F
L
H
E
H
K
A
V
K
K
V
Y
Y
-----------------
P
----------------
G
LPDHPG
H
E
I
A
K
K
Q
MKM-
F
----------------
G
----------------
S
M
I
A
F
D
V
D
G
-
L
-
E
K
A
K
-
K
-
V
-
L
D
N
C
H
V
V
S
L
A
V
S
L
G
G
P
E
S
L
I
Q
H
P
A
S
M
T
H
A
G
V
P
K
E
E
R
E
A
A
G
L
T
D
N
L
I
R
L
S
V
G
C
E
N
V
Q
D
I
I
D
D
L
K
Q
A
L
D
L
V
------
24
PsiBlast_CBE
86.36
39%
-103
- C1 -
4L0O
1
METB_HELPY
G:
[15-378]
-------------------
D
A
--
T
T
G
A
V
S
V
P
I
Y
Q
T
S
T
Y
R
Q
D
A
I
--------
G
------------------------
Y
E
Y
S
R
S
G
N
P
T
R
F
A
L
E
E
L
I
A
D
L
E
G
G
V
K
G
F
A
F
A
S
G
L
A
G
I
H
-
A
-
V
F
S
L
L
-
Q
S
G
D
H
V
L
L
G
D
D
V
Y
G
G
T
F
R
L
F
N
Q
V
L
V
K
-
N
G
L
S
C
T
I
I
D
T
S
-
D
I
S
Q
I
K
K
A
I
K
P
N
T
K
A
L
Y
L
E
T
P
S
N
P
L
L
K
I
T
D
L
A
-
Q
C
A
S
V
A
K
----
D
-
H
-
G
-
L
L
T
I
V
D
N
T
F
A
T
P
-
Y
Y
Q
N
P
L
L
L
G
A
D
I
V
A
H
S
G
T
K
Y
L
G
G
H
S
D
V
V
A
-
G
L
V
T
T
N
N
E
A
-
L
A
Q
-
E
------
I
--------------------------
A
-
F
--
F
--
Q
N
A
I
G
G
V
L
G
P
Q
D
S
W
L
L
Q
R
G
I
K
T
L
G
L
R
M
E
A
H
Q
K
N
A
L
C
V
A
E
F
L
E
K
H
P
K
V
E
R
V
Y
Y
-----------------
P
----------------
G
-----------------
L
PTHPNYELAKKQMRGF
S
----------------
G
M
L
S
F
T
L
K
N
-
D
-
S
E
A
V
-
A
-
F
-
V
E
S
L
K
L
F
I
L
G
E
S
L
G
G
V
E
S
L
V
G
I
P
A
F
M
T
----------
A
A
G
I
R
D
G
L
V
R
L
S
V
G
I
E
H
E
Q
D
L
L
E
D
L
E
Q
A
F
A
K
-------
21
PsiBlast_CBE
86.24
39%
-104
- C1 -
4L0O
2
METB_HELPY
O:
[15-378]
-------------------
D
A
--
T
T
G
A
V
S
V
P
I
Y
Q
T
S
T
Y
R
Q
D
A
I
--------
G
--------
R
H
--------
K
----
G
Y
E
Y
S
R
S
G
N
P
T
R
F
A
L
E
E
L
I
A
D
L
E
G
G
V
K
G
F
A
F
A
S
G
L
A
G
I
H
-
A
-
V
F
S
L
L
-
Q
S
G
D
H
V
L
L
G
D
D
V
Y
G
G
T
F
R
L
F
N
Q
V
L
V
K
-
N
G
L
S
C
T
I
I
D
T
S
-
D
I
S
Q
I
K
K
A
I
K
P
N
T
K
A
L
Y
L
E
T
P
S
N
P
L
L
K
I
T
D
L
A
-
Q
C
A
S
V
A
K
----
D
-
H
-
G
-
L
L
T
I
V
D
N
T
F
A
T
P
-
Y
Y
Q
N
P
L
L
L
G
A
D
I
V
A
H
S
G
T
K
Y
L
G
G
H
S
D
V
V
A
-
G
L
V
T
T
N
N
E
A
-
L
A
Q
-
E
------
I
--------------------------
A
-
F
--
F
--
Q
N
A
I
G
G
V
L
G
P
Q
D
S
W
L
L
Q
R
G
I
K
T
L
G
L
R
M
E
A
H
Q
K
N
A
L
C
V
A
E
F
L
E
K
H
P
K
V
E
R
V
Y
Y
-----------------
P
----------------
G
-----------------
L
PTHPNYELAKKQMRGF
S
----------------
G
M
L
S
F
T
L
K
N
-
D
-
S
E
A
V
-
A
-
F
-
V
E
S
L
K
L
F
I
L
G
E
S
L
G
G
V
E
S
L
V
G
I
P
A
F
M
------------
A
G
I
R
D
G
L
V
R
L
S
V
G
I
E
H
E
Q
D
L
L
E
D
L
E
Q
A
F
A
K
-------
108
HHSearch
85.98
35%
-97
- C1 -
2RFV
1
?
A:
[9-397]
-
F
N
T
Q
I
V
H
A
G
Q
-------
Q
P
D
P-
S
T
G
A
L
S
T
P
I
F
Q
T
S
T
F
V
F
D
S
A
--------
E
Q
G
A
A
R
F-----------------
G
Y
I
Y
T
R
L
G
N
P
T
T
D
A
L
E
K
K
L
A
V
L
E
R
G
E
A
G
L
A
T
A
S
G
I
S
A
I
T
T
T
-
L
L
T
L
C
-
Q
Q
G
D
H
I
V
S
A
S
A
I
Y
G
C
T
H
A
F
L
S
H
S
M
P
K
-
F
G
I
N
V
R
F
V
D
A
A
-
K
P
E
E
I
R
A
A
M
R
P
E
T
K
V
V
Y
I
E
T
P
A
N
P
T
L
S
L
V
D
I
E
-
T
V
A
G
I
A
H
----
Q
-
Q
-
G
-
A
L
L
V
V
D
N
T
F
M
S
P
-
Y
C
Q
Q
P
L
Q
L
G
A
D
I
V
V
H
S
V
T
K
Y
I
N
G
H
G
-
D
V
I
G
G
I
I
V
G
K
Q
E
--
F
I
D
-
Q
------
A
--------------------------
R
-
F
VG
L
--
K
D
I
T
G
G
C
M
S
P
F
N
A
W
L
T
L
R
G
V
K
T
L
G
I
R
M
E
R
H
C
E
N
A
L
K
I
A
R
F
L
E
G
H
P
S
I
T
R
V
Y
Y
-----------------
P
GLSSHP
Q
Y
E
L
G
Q
R
Q
MS
L
-----------------
P
----------------
G
----------------
G
I
I
S
F
E
I
A
G
-
G
L
E
A
G
R
-
R
-
M
-
I
N
S
V
E
L
C
L
L
A
V
S
L
G
D
T
E
T
L
I
Q
H
P
A
S
M
T
H
S
P
V
A
P
E
E
R
L
K
A
G
I
T
D
G
L
I
R
L
S
V
G
L
E
D
P
E
D
I
I
N
D
L
E
H
A
I
R
K
A
T
-----
27
PsiBlast_CBE
85.97
39%
-106
- C1 -
4L0O
2
METB_HELPY
A:
[15-378]
-------------------
D
A
--
T
T
G
A
V
S
V
P
I
Y
Q
T
S
T
Y
R
Q
D
A
I
--------
G
--------
R
H
--------
K
----
G
Y
E
Y
S
R
S
G
N
P
T
R
F
A
L
E
E
L
I
A
D
L
E
G
G
V
K
G
F
A
F
A
S
G
L
A
G
I
H
-
A
-
V
F
S
L
L
-
Q
S
G
D
H
V
L
L
G
D
D
V
Y
G
G
T
F
R
L
F
N
Q
V
L
V
K
-
N
G
L
S
C
T
I
I
D
T
S
-
D
I
S
Q
I
K
K
A
I
K
P
N
T
K
A
L
Y
L
E
T
P
S
N
P
L
L
K
I
T
D
L
A
-
Q
C
A
S
V
A
K
----
D
-
H
-
G
-
L
L
T
I
V
D
N
T
F
A
T
P
-
Y
Y
Q
N
P
L
L
L
G
A
D
I
V
A
H
S
G
T
K
Y
L
G
G
H
S
D
V
V
A
-
G
L
V
T
T
N
N
E
A
-
L
A
Q
-
E
------
I
--------------------------
A
-
F
--
F
--
Q
N
A
I
G
G
V
L
G
P
Q
D
S
W
L
L
Q
R
G
I
K
T
L
G
L
R
M
E
A
H
Q
K
N
A
L
C
V
A
E
F
L
E
K
H
P
K
V
E
R
V
Y
Y
-----------------
P
----------------
G
-----------------
L
PTHPN
Y
E
L
A
K
K
Q
MRGF
S
----------------
G
M
L
S
F
T
L
K
N
-
D
-
S
E
A
V
-
A
-
F
-
V
E
S
L
K
L
F
I
L
G
E
S
L
G
G
V
E
S
L
V
G
I
P
A
F
M
T
----------------
G
L
V
R
L
S
V
G
I
E
H
E
Q
D
L
L
E
D
L
E
Q
A
F
A
K
-------
8
PsiBlast_PDB
85.61
34%
-96
- C1 -
3MKJ
1
?
A:
[21-396]
-------------------
D
P
--
S
T
G
A
L
S
T
P
I
F
Q
T
S
T
F
V
F
D
S
A
--------
E
--------
Q
G
A
A
R
F---------------
L
G
N
P
T
T
D
A
L
E
K
K
L
A
V
L
E
R
G
E
A
G
L
A
T
A
S
G
I
S
A
I
T
-
T
T
L
L
T
L
C
-
Q
Q
G
D
H
I
V
S
A
S
A
I
Y
G
C
T
H
A
F
L
S
H
S
M
P
K
-
F
G
I
N
V
S
F
V
D
A
A
-
K
P
E
E
I
R
A
A
M
R
P
E
T
K
V
V
Y
I
E
T
P
A
N
P
T
L
S
L
V
D
I
E
-
T
V
A
G
I
A
H
----
Q
-
Q
-
G
-
A
L
L
V
V
D
N
T
F
M
S
P
-
Y
C
Q
Q
P
L
Q
L
G
A
D
I
V
V
H
S
V
T
K
Y
I
N
G
H
G
D
V
I
G
-
G
I
I
V
G
K
Q
E
F
-
I
D
Q
-
A
------
R
--------------------------
F
V
G
--
L
--
K
D
I
T
G
G
C
M
S
P
F
N
A
W
L
T
L
R
G
V
K
T
L
G
I
R
M
E
R
H
C
E
N
A
L
K
I
A
R
F
L
E
G
H
P
S
I
T
R
V
Y
Y
-----------------
P
----------------
G
-----------------
L
----------------
S
S
H
P
Q
Y
E
L
G
Q
RQMSL
P
G
G
I
I
S
F
E
I
A
G
-
G
-
L
E
A
G
R
R
-
M
-
I
N
S
V
E
L
C
L
L
A
V
S
L
G
D
T
E
T
L
I
Q
H
P
A
S
M
T
H
S
P
V
A
P
E
E
R
L
K
A
G
I
T
D
G
L
I
R
L
S
V
G
L
E
D
P
E
D
I
I
N
D
L
E
H
A
I
R
K
A
------
7
PsiBlast_PDB
85.42
34%
-97
- C1 -
4HF8
5
?
A:
[21-396]
-------------------
D
P
--
S
T
G
A
L
S
T
P
I
F
Q
T
S
T
F
V
F
D
S
A
--------
E
--------
Q
G
A
A
R
F
A
LE
E
S
----
G
Y
I
Y
T
R
L
G
N
P
T
T
D
A
L
E
K
K
L
A
V
L
E
R
G
E
A
G
L
A
T
A
S
G
I
S
A
I
T
-
T
T
L
L
T
L
C
-
Q
Q
G
D
H
I
V
S
A
S
A
I
Y
G
C
T
H
A
F
L
S
H
S
M
P
K
-
F
G
I
N
V
R
F
V
D
A
A
-
K
P
E
E
I
R
A
A
M
R
P
E
T
K
V
V
Y
I
E
T
P
A
N
P
T
L
S
L
V
D
I
E
-
T
V
A
G
I
A
H
----
Q
-
Q
-
G
-
A
L
L
V
V
D
N
T
F
M
S
P
-
Y
C
Q
Q
P
L
Q
L
G
A
D
I
V
V
H
S
V
T
K
Y
I
N
G
H
G
D
V
I
G
-
G
I
I
V
G
K
Q
E
F
-
I
D
Q
-
A
------
R
--------------------------
F
V
G
--
L
--
K
D
I
T
G
G
C
M
S
P
F
N
A
W
L
T
L
R
G
V
K
T
L
G
I
R
M
E
R
H
C
E
N
A
L
K
I
A
R
F
L
E
G
H
P
S
I
T
R
V
Y
Y
-----------------
P
----------------
G
-----------------
L
----------------
S
SHPQ
Y
E
L
G
Q
R
QMSLPG
G
I
I
S
F
E
I
A
G
-
G
-
L
E
A
G
R
R
-
M
-
I
N
S
V
E
L
C
L
L
A
V
S
L
G
D
T
E
T
L
I
Q
H
P
A
S
M
T
H
S
P
V
A
P
E
E
R
L
K
A
G
I
T
D
G
L
I
R
L
S
V
G
L
E
D
P
E
D
I
I
N
D
L
E
H
A
I
R
K
A
------
9
PsiBlast_PDB
85.41
34%
-97
- C1 -
4OMA
6
?
A:
[21-396]
-------------------
D
P
--
S
T
G
A
L
S
T
P
I
F
Q
T
S
T
F
V
F
D
S
A
--------
E
--------
Q
G
A
A
R
F
A
LE
E
S
----
G
Y
I
Y
T
R
L
G
N
P
T
T
D
A
L
E
K
K
L
A
V
L
E
R
G
E
A
G
L
A
T
A
S
G
I
S
A
I
T
-
T
T
L
L
T
L
C
-
Q
Q
G
D
H
I
V
S
A
S
A
I
Y
G
C
T
H
A
F
L
S
H
S
M
P
K
-
F
G
I
N
V
S
F
V
D
A
A
-
K
P
E
E
I
R
A
A
M
R
P
E
T
K
V
V
Y
I
E
T
P
A
N
P
T
L
S
L
V
D
I
E
-
T
V
A
G
I
A
H
----
Q
-
Q
-
G
-
A
L
L
V
V
D
N
T
F
M
S
P
-
Y
C
Q
Q
P
L
Q
L
G
A
D
I
V
V
H
S
V
T
K
Y
I
N
G
H
G
D
V
I
G
-
G
I
I
V
G
K
Q
E
F
-
I
D
Q
-
A
------
R
--------------------------
F
V
G
--
L
--
K
D
I
T
G
G
C
M
S
P
F
N
A
W
L
T
L
R
G
V
K
T
L
G
I
R
M
E
R
H
C
E
N
A
L
K
I
A
R
F
L
E
G
H
P
S
I
T
R
V
Y
Y
-----------------
P
----------------
G
-----------------
L
----------------
S
SHPQ
Y
E
L
G
Q
R
Q
M
SLPG
G
I
I
S
F
E
I
A
G
-
G
-
L
E
A
G
R
R
-
M
-
I
N
S
V
E
L
C
L
L
A
V
S
L
G
D
T
E
T
L
I
Q
H
P
A
S
M
T
H
S
P
V
A
P
E
E
R
L
K
A
G
I
T
D
G
L
I
R
L
S
V
G
L
E
D
P
E
D
I
I
N
D
L
E
H
A
I
R
K
A
------
107
HHSearch
85.23
34%
-97
- C1 -
1IBJ
4
METC_ARATH
A:
[88-463]
--
S
T
L
L
V
N
L
D
N
-------
K
F
D
--
P
F
D
A
M
S
T
P
L
Y
Q
T
A
T
F
K
Q
P
S
A
--------
I
--------
E
N
--------
G
----
P
Y
D
Y
T
R
S
G
N
P
T
R
D
A
L
E
S
L
L
A
K
L
D
K
A
D
R
A
F
C
F
T
S
G
M
A
A
L
S
A
V
-
T
-
H
L
I
-
K
N
G
E
E
I
V
A
G
D
D
V
Y
G
G
S
D
R
L
L
S
Q
V
V
P
R
-
S
G
V
V
V
K
R
V
N
T
T
-
K
L
D
E
V
A
A
A
I
G
P
Q
T
K
L
V
W
L
E
S
P
T
N
P
R
Q
Q
I
S
D
I
R
-
K
I
S
E
M
A
H
----
A
-
Q
-
G
-
A
L
V
L
V
D
N
S
I
M
S
P
-
V
L
S
R
P
L
E
L
G
A
D
I
V
M
H
S
A
T
K
F
I
A
G
H
S
D
V
M
A
-
G
V
L
A
V
K
G
E
K
-
L
A
K
-
E
------
V
--------------------------
Y
-
F
--
L
--
Q
N
S
E
G
S
G
L
A
P
F
D
C
W
L
C
L
R
G
I
K
T
M
A
L
R
I
E
K
Q
Q
E
N
A
R
K
I
A
M
Y
L
S
S
H
P
R
V
K
K
V
Y
Y
-----------------
A
GLPDHPG
H
H
L
H
F
S
Q
A
K
G
-----------------
A
----------------
G
----------------
S
V
F
S
F
I
T
G
S
-
V
-
A
L
S
K
-
H
-
L
-
V
E
T
T
K
Y
F
S
I
A
V
S
F
G
S
V
K
S
L
I
S
M
P
C
F
M
S
H
A
S
I
P
A
E
V
R
E
A
R
G
L
T
E
D
L
V
R
I
S
A
G
I
E
D
V
D
D
L
I
S
D
L
D
I
A
F
K
T
F
P
-----
103
HHSearch
85.10
35%
-93
- C1 -
1E5E
5
?
A:
[8-397]
-
P
A
T
A
C
I
H
A
N
P
-------
Q
K
D
--
Q
F
G
A
A
I
P
P
I
Y
Q
T
S
T
F
V
F
D
N
C
Q
Q
G
G
N
R
F
A
G
--------
Q
E
--------
S
----
G
Y
I
Y
T
R
L
G
N
P
T
V
S
N
L
E
G
K
I
A
F
L
E
K
T
E
A
C
V
A
T
S
S
G
M
G
A
I
A
A
T
-
V
L
T
I
L
-
K
A
G
D
H
L
I
S
D
E
C
L
Y
G
C
T
H
A
L
F
E
H
A
L
T
K
-
F
G
I
Q
V
D
F
I
N
T
A
-
I
P
G
E
V
K
K
H
M
K
P
N
T
K
I
V
Y
F
E
T
P
A
N
P
T
L
K
I
I
D
M
E
-
R
V
C
K
D
A
H
----
S
Q
E
-
G
-
V
L
V
I
A
D
N
T
F
C
S
P
-
M
I
T
N
P
V
D
F
G
V
D
V
V
V
H
S
A
T
K
Y
I
N
G
H
T
D
V
V
A
-
G
L
I
C
G
K
A
D
--
L
L
Q
-
Q
------
I
--------------------------
R
-
M
--
V
GI
K
D
I
T
G
S
V
I
S
P
H
D
A
W
L
I
T
R
G
L
S
T
L
N
I
R
M
K
A
E
S
E
N
A
M
K
V
A
E
Y
L
K
S
H
P
A
V
E
K
V
Y
Y
-----------------
P
GFEDHEG
H
D
I
A
K
K
Q
M
R
M
-----------------
Y
----------------
G
----------------
S
M
I
T
F
I
L
K
S
-
G
F
E
G
A
K
-
K
-
L
-
L
D
N
L
K
L
I
T
L
A
V
S
L
G
G
C
E
S
L
I
Q
H
P
A
S
M
T
H
A
V
V
P
K
E
E
R
E
A
A
G
I
T
D
G
M
I
R
L
S
V
G
I
E
D
A
D
E
L
I
A
D
F
K
Q
G
L
D
A
L
L
R
----
13
PsiBlast_PDB
84.55
33%
-95
- C1 -
3JWA
6
?
A:
[21-396]
-------------------
D
P
--
S
T
G
A
L
S
T
P
I
F
Q
T
S
T
F
V
F
D
S
A
--------
E
--------
Q
G
A
A
R
F
A
LE
E
S
----
G
Y
I
Y
T
R
L
G
N
P
T
T
D
A
L
E
K
K
L
A
V
L
E
R
G
E
A
G
L
A
T
A
S
G
I
S
A
I
T
-
T
T
L
L
T
L
C
-
Q
Q
G
D
H
I
V
S
A
S
A
I
Y
G
C
T
H
A
F
L
S
H
S
M
P
K
-
F
G
I
N
V
S
F
V
D
A
A
-
K
P
E
E
I
R
A
A
M
R
P
E
T
K
V
V
Y
I
E
T
P
A
N
P
T
L
S
L
V
D
I
E
-
T
V
A
G
I
A
H
----
Q
-
Q
-
G
-
A
L
L
V
V
D
N
T
F
M
S
P
-
Y
C
Q
Q
P
L
Q
L
G
A
D
I
V
V
H
S
V
T
K
Y
I
N
G
H
G
D
V
I
G
-
G
I
I
V
G
K
Q
E
F
-
I
D
Q
-
A
------
R
--------------------------
F
V
G
--
L
--
K
D
I
T
G
G
C
M
S
P
F
N
A
W
L
T
L
R
G
V
K
T
L
G
I
R
M
E
R
H
C
E
N
A
L
K
I
A
R
F
L
E
G
H
P
S
I
T
R
V
Y
Y
-----------------
P
----------------
G
-----------------
L
----------------
S
SHP
Q
Y
E
L
G
Q
R
Q
MSLPG
G
I
I
S
F
E
I
A
G
-
G
-
L
E
A
G
R
R
-
M
-
I
N
S
V
E
L
C
L
L
A
V
S
L
G
D
T
E
T
L
I
Q
H
P
A
S
M
T
H
S
P
V
A
P
E
E
R
L
K
A
G
I
T
D
G
L
I
R
L
S
V
G
L
E
D
P
E
D
I
I
N
D
L
E
H
A
I
R
K
A
------
12
PsiBlast_PDB
84.06
33%
-96
- C1 -
3JW9
2
?
A:
[21-396]
-------------------
D
P
--
S
T
G
A
L
S
T
P
I
F
Q
T
S
T
F
V
F
D
S
A
--------
E
--------
Q
G
A
A
R
F
A
LE
E
S
----
G
Y
I
Y
T
R
L
G
N
P
T
T
D
A
L
E
K
K
L
A
V
L
E
R
G
E
A
G
L
A
T
A
S
G
I
S
A
I
T
-
T
T
L
L
T
L
C
-
Q
Q
G
D
H
I
V
S
A
S
A
I
Y
G
C
T
H
A
F
L
S
H
S
M
P
K
-
F
G
I
N
V
S
F
V
D
A
A
-
K
P
E
E
I
R
A
A
M
R
P
E
T
K
V
V
Y
I
E
T
P
A
N
P
T
L
S
L
V
D
I
E
-
T
V
A
G
I
A
H
----
Q
-
Q
-
G
-
A
L
L
V
V
D
N
T
F
M
S
P
-
Y
C
Q
Q
P
L
Q
L
G
A
D
I
V
V
H
S
V
T
K
Y
I
N
G
H
G
D
V
I
G
-
G
I
I
V
G
K
Q
E
F
-
I
D
Q
-
A
------
R
--------------------------
F
V
G
--
L
--
K
D
I
T
G
G
C
M
S
P
F
N
A
W
L
T
L
R
G
V
K
T
L
G
I
R
M
E
R
H
C
E
N
A
L
K
I
A
R
F
L
E
G
H
P
S
I
T
R
V
Y
Y
-----------------
P
----------------
G
-----------------
L
----------------
S
SHP
Q
Y
E
L
G
Q
R
Q
MSLPG
G
I
I
S
F
E
I
A
G
-
G
-
L
E
A
G
R
R
-
M
-
I
N
S
V
E
L
C
L
L
A
V
S
L
G
D
T
E
T
L
I
Q
H
P
A
S
M
T
H
S
P
V
A
P
E
E
R
L
K
A
G
I
T
D
G
L
I
R
L
S
V
G
L
E
D
P
E
D
I
I
N
D
L
E
H
A
I
R
K
A
------
14
PsiBlast_PDB
83.46
33%
-94
- C1 -
3JWB
4
?
A:
[21-396]
-------------------
D
P
--
S
T
G
A
L
S
T
P
I
F
Q
T
S
T
F
V
F
D
S
A
--------
E
--------
Q
G
A
A
R
F
A
LE
E
S
----
G
Y
I
Y
T
R
L
G
N
P
T
T
D
A
L
E
K
K
L
A
V
L
E
R
G
E
A
G
L
A
T
A
S
G
I
S
A
I
T
-
T
T
L
L
T
L
C
-
Q
Q
G
D
H
I
V
S
A
S
A
I
Y
G
C
T
H
A
F
L
S
H
S
M
P
K
-
F
G
I
N
V
S
F
V
D
A
A
-
K
P
E
E
I
R
A
A
M
R
P
E
T
K
V
V
Y
I
E
T
P
A
N
P
T
L
S
L
V
D
I
E
-
T
V
A
G
I
A
H
----
Q
-
Q
-
G
-
A
L
L
V
V
D
N
T
F
M
S
P
-
Y
C
Q
Q
P
L
Q
L
G
A
D
I
V
V
H
S
V
T
K
Y
I
N
G
H
G
D
V
I
G
-
G
I
I
V
G
K
Q
E
F
-
I
D
Q
-
A
------
R
--------------------------
F
V
G
--
L
--
K
D
I
T
G
G
C
M
S
P
F
N
A
W
L
T
L
R
G
V
K
T
L
G
I
R
M
E
R
H
C
E
N
A
L
K
I
A
R
F
L
E
G
H
P
S
I
T
R
V
Y
Y
-----------------
P
----------------
G
-----------------
L
----------------
S
SHP
Q
Y
E
L
G
Q
R
Q
MSLPG
G
I
I
S
F
E
I
A
G
-
G
-
L
E
A
G
R
R
-
M
-
I
N
S
V
E
L
C
L
L
A
V
S
L
G
D
T
E
T
L
I
Q
H
P
A
S
M
T
H
S
P
V
A
P
E
E
R
L
K
A
G
I
T
D
G
L
I
R
L
S
V
G
L
E
D
P
E
D
I
I
N
D
L
E
H
A
I
R
K
A
------
63
PsiBlast_CBE
83.23
36%
-101
- C1 -
1PFF
18
?
A:
[1-328]
---------------------------------------------------------------------------------------
S
A
L
E
G
K
I
A
K
L
E
H
A
E
A
C
A
A
T
A
S
G
M
G
A
I
A
-
A
S
V
W
T
F
L
-
K
A
G
D
H
L
I
S
D
D
C
L
Y
G
C
T
H
A
L
F
E
H
Q
L
R
K
-
F
G
V
E
V
D
F
I
D
M
A
-
V
P
G
N
I
E
K
H
L
K
P
N
T
R
I
V
Y
F
E
T
P
A
N
P
T
L
K
V
I
D
I
E
D
A
V
K
Q
A
R
K
----
Q
-
K
-
D
-
I
L
V
I
V
D
N
T
F
A
S
P
-
I
L
T
N
P
L
D
L
G
V
D
I
V
V
H
S
A
T
K
Y
I
N
G
H
T
D
V
V
A
-
G
L
V
C
S
R
A
D
I
-
I
A
K
V
K
------
S
--------------------------
Q
-
G
--
I
--
K
D
I
T
G
A
I
I
S
P
H
D
A
W
L
I
T
R
G
T
L
T
L
D
M
R
V
K
R
A
A
E
N
A
Q
K
V
A
E
F
L
H
E
H
K
A
V
K
K
V
Y
Y
-----------------
P
----------------
G
-----------------
L
----------------
P
DHPG
H
E
I
A
K
K
Q
MKMFG
S
M
I
A
F
D
V
D
G
-
L
-
E
K
A
K
-
K
-
V
-
L
D
N
C
H
V
V
S
L
A
V
S
L
G
G
P
E
S
L
I
Q
H
P
A
S
M
T
H
A
G
V
P
K
E
E
R
E
A
A
G
L
T
D
N
L
I
R
L
S
V
G
C
E
N
V
Q
D
I
I
D
D
L
K
Q
A
L
D
--------
58
PsiBlast_CBE
83.23
35%
-95
- C1 -
1E5F
5
?
B:
[49-393]
---------------------------------------------------
G
--------
Q
E
--------
S
----
G
Y
I
Y
T
R
L
G
N
P
T
V
S
N
L
E
G
K
I
A
F
L
E
K
T
E
A
C
V
A
T
S
S
G
M
G
A
I
A
-
A
T
V
L
T
I
L
-
K
A
G
D
H
L
I
S
D
E
C
L
Y
G
C
T
H
A
L
F
E
H
A
L
T
K
-
F
G
I
Q
V
D
F
I
N
T
A
-
I
P
G
E
V
K
K
H
M
K
P
N
T
K
I
V
Y
F
E
T
P
A
N
P
T
L
K
I
I
D
M
E
----
R
V
C
K
DAHS
Q
-
E
-
G
-
V
L
V
I
A
D
N
T
F
C
S
P
-
M
I
T
N
P
V
D
F
G
V
D
V
V
V
H
S
A
T
K
Y
I
N
G
H
T
D
V
V
A
-
G
L
I
C
G
K
A
D
L
-
L
Q
Q
I
R
------
M
--------------------------
V
-
G
--
I
--
K
D
I
T
G
S
V
I
S
P
H
D
A
W
L
I
T
R
G
L
S
T
L
N
I
R
M
K
A
E
S
E
N
A
M
K
V
A
E
Y
L
K
S
H
P
A
V
E
K
V
Y
Y
-----------------
P
----------------
G
FEDHEGHDIAKKQMRM-
Y
----------------
G
----------------
S
M
I
T
F
I
L
K
S
-
G
-
F
E
G
A
K
K
-
L
-
L
D
N
L
K
L
I
T
L
A
V
S
L
G
G
C
E
S
L
I
Q
H
P
A
S
M
T
H
A
V
V
P
K
E
E
R
E
A
A
G
I
T
D
G
M
I
R
L
S
V
G
I
E
D
A
D
E
L
I
A
D
F
K
Q
G
L
D
--------
61
PsiBlast_CBE
81.55
35%
-96
- C1 -
1E5E
5
?
A:
[49-393]
---------------------------------------------------
G
--------
Q
E
--------
S
----
G
Y
I
Y
T
R
L
G
N
P
T
V
S
N
L
E
G
K
I
A
F
L
E
K
T
E
A
C
V
A
T
S
S
G
M
G
A
I
A
-
A
T
V
L
T
I
L
-
K
A
G
D
H
L
I
S
D
E
C
L
Y
G
C
T
H
A
L
F
E
H
A
L
T
K
-
F
G
I
Q
V
D
F
I
N
T
A
-
I
P
G
E
V
K
K
H
M
K
P
N
T
K
I
V
Y
F
E
T
P
A
N
P
T
L
K
I
I
D
M
E
----
R
V
C
K
D
A
H
S
Q
-
E
-
G
-
V
L
V
I
A
D
N
T
F
C
S
P
-
M
I
T
N
P
V
D
F
G
V
D
V
V
V
H
S
A
T
K
Y
I
N
G
H
T
D
V
V
A
-
G
L
I
C
G
K
A
D
L
-
L
Q
Q
I
R
------
M
--------------------------
V
-
G
--
I
--
K
D
I
T
G
S
V
I
S
P
H
D
A
W
L
I
T
R
G
L
S
T
L
N
I
R
M
K
A
E
S
E
N
A
M
K
V
A
E
Y
L
K
S
H
P
A
V
E
K
V
Y
Y
-----------------
P
----------------
G
FEDHEG
H
D
I
A
K
K
Q
M
RM-
Y
----------------
G
----------------
S
M
I
T
F
I
L
K
S
-
G
-
F
E
G
A
K
K
-
L
-
L
D
N
L
K
L
I
T
L
A
V
S
L
G
G
C
E
S
L
I
Q
H
P
A
S
M
T
H
A
V
V
P
K
E
E
R
E
A
A
G
I
T
D
G
M
I
R
L
S
V
G
I
E
D
A
D
E
L
I
A
D
F
K
Q
G
L
D
--------
6
PsiBlast_PDB
81.19
33%
-95
- C1 -
1IBJ
4
METC_ARATH
A:
[99-455]
--------------------
D
--
P
F
D
A
M
S
T
P
L
Y
Q
T
A
T
F
K
Q
P
S
A
--------
I
--------
E
N
--------
G
----
P
Y
D
Y
T
R
S
G
N
P
T
R
D
A
L
E
S
L
L
A
K
L
D
K
A
D
R
A
F
C
F
T
S
G
M
A
A
L
S
-
A
-
V
T
H
L
I
-
K
N
G
E
E
I
V
A
G
D
D
V
Y
G
G
S
D
R
L
L
S
Q
V
V
P
R
-
S
G
V
V
V
K
R
V
N
T
T
-
K
L
D
E
V
A
A
A
I
G
P
Q
T
K
L
V
W
L
E
S
P
T
N
P
R
Q
Q
I
S
D
I
R
-
K
I
S
E
M
A
H
----
A
-
Q
-
G
-
A
L
V
L
V
D
N
S
I
M
S
P
-
V
L
S
R
P
L
E
L
G
A
D
I
V
M
H
S
A
T
K
F
I
A
G
H
S
D
V
M
A
-
G
V
L
A
V
K
G
E
K
-
L
A
K
-
E
------
V
--------------------------
Y
-
F
--
L
--
Q
N
S
E
G
S
G
L
A
P
F
D
C
W
L
C
L
R
G
I
K
T
M
A
L
R
I
E
K
Q
Q
E
N
A
R
K
I
A
M
Y
L
S
S
H
P
R
V
K
K
V
Y
Y
-----------------
A
----------------
G
LPDHPG
H
H
L
H
F
S
Q
A
K--
G
----------------
A
----------------
G
S
V
F
S
F
I
T
G
-
S
-
V
A
L
S
-
K
H
L
-
V
E
T
T
K
Y
F
S
I
A
V
S
F
G
S
V
K
S
L
I
S
M
P
C
F
M
S
H
A
S
I
P
A
E
V
R
E
A
R
G
L
T
E
D
L
V
R
I
S
A
G
I
E
D
V
D
D
L
I
S
D
L
-------------
59
PsiBlast_CBE
80.81
35%
-95
- C1 -
1E5F
6
?
A:
[49-393]
---------------------------------------------------
G
--------
Q
E
--------
S
----
G
Y
I
Y
T
R
L
G
N
P
T
V
S
N
L
E
G
K
I
A
F
L
E
K
T
E
A
C
V
A
T
S
S
G
M
G
A
I
A
-
A
T
V
L
T
I
L
-
K
A
G
D
H
L
I
S
D
E
C
L
Y
G
C
T
H
A
L
F
E
H
A
L
T
K
-
F
G
I
Q
V
D
F
I
N
T
A
-
I
P
G
E
V
K
K
H
M
K
P
N
T
K
I
V
Y
F
E
T
P
A
N
P
T
L
K
I
I
D
M
E
----
R
V
C
K
D
A
H
S
Q
-
E
-
G
-
V
L
V
I
A
D
N
T
F
C
S
P
-
M
I
T
N
P
V
D
F
G
V
D
V
V
V
H
S
A
T
K
Y
I
N
G
H
T
D
V
V
A
-
G
L
I
C
G
K
A
D
L
-
L
Q
Q
I
R
------
M
--------------------------
V
-
G
--
I
--
K
D
I
T
G
S
V
I
S
P
H
D
A
W
L
I
T
R
G
L
S
T
L
N
I
R
M
K
A
E
S
E
N
A
M
K
V
A
E
Y
L
K
S
H
P
A
V
E
K
V
Y
Y
-----------------
P
----------------
G
FEDHEG
H
D
I
A
K
K
Q
M
RM-
Y
----------------
G
----------------
S
M
I
T
F
I
L
K
S
-
G
-
F
E
G
A
K
K
-
L
-
L
D
N
L
K
L
I
T
L
A
V
S
L
G
G
C
E
S
L
I
Q
H
P
A
S
M
T
H
A
V
V
P
K
E
E
R
E
A
A
G
I
T
D
G
M
I
R
L
S
V
G
I
E
D
A
D
E
L
I
A
D
F
K
Q
G
L
D
--------
60
PsiBlast_CBE
80.08
35%
-96
- C1 -
1E5E
6
?
B:
[49-393]
---------------------------------------------------
G
--------
Q
E
--------
S
----
G
Y
I
Y
T
R
L
G
N
P
T
V
S
N
L
E
G
K
I
A
F
L
E
K
T
E
A
C
V
A
T
S
S
G
M
G
A
I
A
-
A
T
V
L
T
I
L
-
K
A
G
D
H
L
I
S
D
E
C
L
Y
G
C
T
H
A
L
F
E
H
A
L
T
K
-
F
G
I
Q
V
D
F
I
N
T
A
-
I
P
G
E
V
K
K
H
M
K
P
N
T
K
I
V
Y
F
E
T
P
A
N
P
T
L
K
I
I
D
M
E
----
R
V
C
K
DAHS
Q
-
E
-
G
-
V
L
V
I
A
D
N
T
F
C
S
P
-
M
I
T
N
P
V
D
F
G
V
D
V
V
V
H
S
A
T
K
Y
I
N
G
H
T
D
V
V
A
-
G
L
I
C
G
K
A
D
L
-
L
Q
Q
I
R
------
M
--------------------------
V
-
G
--
I
--
K
D
I
T
G
S
V
I
S
P
H
D
A
W
L
I
T
R
G
L
S
T
L
N
I
R
M
K
A
E
S
E
N
A
M
K
V
A
E
Y
L
K
S
H
P
A
V
E
K
V
Y
Y
-----------------
P
----------------
G
FEDHEGHDIAKKQMRM-
Y
----------------
G
----------------
S
M
I
T
F
I
L
K
S
-
G
-
F
E
G
A
K
K
-
L
-
L
D
N
L
K
L
I
T
L
A
V
S
L
G
G
C
E
S
L
I
Q
H
P
A
S
M
T
H
A
V
V
P
K
E
E
R
E
A
A
G
I
T
D
G
M
I
R
L
S
V
G
I
E
D
A
D
E
L
I
A
D
F
K
Q
G
L
D
--------
110
HHSearch
78.24
30%
-86
- C1 -
2CTZ
1
?
A:
[3-421]
-
F
E
T
L
Q
L
H
A
G
Y
-------
E
P
E
P-
T
T
L
S
R
Q
V
P
I
Y
P
T
T
S
Y
V
F
K
S
P
--------
E
H
A
A
N
L
F
A
L
K
E
--------
F
----
G
N
I
Y
S
R
I
M
N
P
T
V
D
V
L
E
K
R
L
A
A
L
E
G
G
K
A
A
L
A
T
A
S
G
H
A
A
Q
F
L
A
-
L
T
T
L
A
-
Q
A
G
D
N
I
V
S
T
P
N
L
Y
G
G
T
F
N
Q
F
K
V
T
L
K
R
-
L
G
I
E
V
R
F
T
S
R
E
E
R
P
E
E
F
L
A
L
T
D
E
K
T
R
A
W
W
V
E
S
I
G
N
P
A
L
N
I
P
D
L
E
-
A
L
A
Q
A
A
R
----
E
-
K
-
G
-
V
A
L
I
V
D
N
T
F
G
M
G
G
Y
L
L
R
P
L
A
W
G
A
A
L
V
T
H
S
L
T
K
W
V
G
G
H
G
-
A
V
I
-
A
G
A
I
V
D
G
G
N
-
F
P
W
-
E
GGRYPL
L
TEPQPGYHGLRLTEAFGEL
A
F
I
V
K
A
R
V
-
D
--
G
--
L
R
D
Q
G
Q
A
L
G
P
F
E
A
W
V
V
L
L
G
M
E
T
L
S
L
R
A
E
R
H
V
E
N
T
L
H
L
A
H
W
L
L
E
Q
P
Q
V
A
W
V
N
Y
-----------------
P
----------------
G
LPHHPH
H
D
R
A
Q
K
Y
FKGK
P
----------------
G
----------------
A
V
L
T
F
G
L
K
G
-
G
Y
E
A
A
K
-
R
-
F
-
I
S
R
L
K
L
I
S
H
L
A
N
V
G
D
T
R
T
L
A
I
H
P
A
S
T
T
H
S
Q
L
S
P
E
E
Q
A
Q
A
G
V
S
P
E
M
V
R
L
S
V
G
L
E
H
V
E
D
L
K
A
E
L
K
E
A
L
A
--------
37
PsiBlast_CBE
78.22
33%
-94
- C1 -
1IBJ
3
METC_ARATH
C:
[99-455]
--------------------
D
--
P
F
D
A
M
S
T
P
L
Y
Q
T
A
T
F
K
Q
P
S
A
--------
I
--------
E
N
--------
G
----
P
Y
D
Y
T
R
S
G
N
P
T
R
D
A
L
E
S
L
L
A
K
L
D
K
A
D
R
A
F
C
F
T
S
G
M
A
A
L
S
-
A
-
V
T
H
L
I
-
K
N
G
E
E
I
V
A
G
D
D
V
Y
G
G
S
D
R
L
L
S
Q
V
V
P
R
-
S
G
V
V
V
K
R
V
N
T
T
-
K
L
D
E
V
A
A
A
I
G
P
Q
T
K
L
V
W
L
E
S
P
T
N
P
R
Q
Q
I
S
D
I
R
-
K
I
S
E
M
A
H
----
A
-
Q
-
G
-
A
L
V
L
V
D
N
S
I
M
S
P
-
V
L
S
R
P
L
E
L
G
A
D
I
V
M
H
S
A
T
K
F
I
A
G
H
S
D
V
M
A
-
G
V
L
A
V
K
G
E
K
-
L
A
K
-
E
------
V
--------------------------
Y
-
F
--
L
--
Q
N
S
E
G
S
G
L
A
P
F
D
C
W
L
C
L
R
G
I
K
T
M
A
L
R
I
E
K
Q
Q
E
N
A
R
K
I
A
M
Y
L
S
S
H
P
R
V
K
K
V
Y
Y
-----------------
A
----------------
G
LPDHPGHHLHFSQAK--
G
----------------
A
----------------
G
S
V
F
S
F
I
T
G
-
S
-
V
A
L
S
-
K
H
L
-
V
E
T
T
K
Y
F
S
I
A
V
S
F
G
S
V
K
S
L
I
S
M
P
C
F
M
S
H
A
S
I
P
A
E
V
R
E
A
R
G
L
T
E
D
L
V
R
I
S
A
G
I
E
D
V
D
D
L
I
S
D
L
-------------