@TOME V2.3
(Nov 2016)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : SA1204: (2016-03-23 )
MNKQIQTEADELGFFGEYGGQYVPETLMPAIIELKKAYKEAKADPEFQRELEYYLSEYVGRATPLTYAASYTESLGGAKIYLKREDLNHTGAHKINNALGQALLAKRMGKKKLVAETGAGQHGVASATVAALFDMELVVFMGSEDIKRQQLNVFRMELLGAKVVAVEEGQGTLSDAVNKALQYWVSHVDDTHYLLGSALGPDPFPTIVRDFQSVIGKEIKSQILKKEGRLPDAIVACIGGGSNAIGTFYPFIKDDVALYGVEAAGQGEDTDKHALAIGKGSPGVLHGTKMYLIQDEGGQVQLAHSISAGLDYPGIGPEHSYYHDIGRVTFENASDTQAMNALINFTKHEGIIPAIESAHALSYVERLAPTMSKEDIIVVTISGRGDKDMETIRQYMAERGLAND
Atome Classification :
(65 SA)
.........10........20........30........40........50........60........70......-..80........90........100.......110-.......120.......130.......140......--.150.......160...-----....170--------.........180.......190.......200.......210.......220.......230.......240.......250---.-.---.....260----.......270.--......----280.......290.......300.......310.......320.......330.......340.......350.......360.-......370.---......380.......390.......400..-
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MNKQIQT
E
A
D
ELGF
F
G
EYGGQYV
P
E
T
L
M
P
A
I
I
E
L
K
K
A
Y
K
E
AKA
D
P
E
F
Q
R
E
L
E
Y
Y
L
S
E
Y
VGRATP
L
T
Y
A
A
S
Y
T
E
SLGG-
A
K
I
Y
L
K
REDLNHT
G
A
H
K
I
N
N
A
L
G
Q
A
L
L
A
K
R
MGKK
K
-
L
V
AETGAGQHG
V
A
S
A
T
V
A
A
L
FD
M
E
L
V
V
F
MGS
E
D
I
K
R
--
Q
Q
L
N
V
F
R
M
E
LLG
A
K
V
V
A
-----
V
EEGQ----------G
T
L
S
D
A
V
N
K
A
L
Q
Y
W
V
S
HVDD
T
H
Y
L
L
GSALGPD
P
F
P
T
I
V
R
D
F
Q
S
V
I
G
K
E
I
K
S
Q
I
L
K
KEGRL
P
D
A
I
V
A
C
IGGGSNA
I
G
TF
Y
P
F
I---K-D---D
V
A
L
Y
G
V
E----AAGQGEDTDK
H
--
A
L
A
IGK----GSPG
V
L
HG
T
K
M
Y
L
I
QDEGG
Q
V
Q
L
A
HSISAGLDYPGIGPEH
S
Y
Y
H
D
IG
R
V
T
FENAS
D
T
Q
A
M
N
A
L
I
NFTKHEGI
I
P
A
I
E
S
A
H
A
L
S
Y
-
V
E
R
LAPTMSK---E
D
I
I
V
V
T
ISGRGDK
D
M
E
T
I
R
Q
Y
M
A
ERGLAND-
102
HHSearch
94.06
56%
-71
- C3 -
1X1Q
1
TRPB_THET2
A:
[22-416]
------
P
L
P
D
A
R
G
R
F
G
P
Y
G
G
R
Y
V
P
E
T
L
I
P
A
L
E
E
L
E
A
A
Y
R
E
A
K
K
D
P
A
F
L
E
E
L
D
H
Y
L
R
Q
F
A
G
R
P
T
P
L
Y
H
A
K
R
L
S
E
Y
W
G
G
-
A
Q
V
F
L
K
R
E
D
L
L
H
T
G
A
H
K
I
N
N
T
L
G
Q
A
L
L
A
R
R
M
G
K
R
R
-
V
I
A
E
T
G
A
G
Q
H
G
V
S
V
A
T
V
A
A
L
F
G
L
E
C
V
V
Y
M
G
E
E
D
V
R
R
Q
A
L
N
--
V
F
R
M
K
L
L
G
A
E
V
R
P
-----
V
A
A
G
S
----------
R
T
L
K
D
A
T
N
E
A
I
R
D
W
I
T
N
V
R
T
T
F
Y
I
L
G
S
V
V
G
P
H
P
Y
P
M
M
V
R
D
F
Q
S
V
I
G
E
E
V
K
R
Q
S
L
E
L
F
G
R
L
P
D
A
L
I
A
A
V
G
G
G
S
N
A
I
G
L
F
A
P
F
A
---
Y
-
L
PEG
R
P
K
L
I
G
V
E
----
A
A
G
E
G
L
S
T
G
R
H
--
A
A
S
I
G
A
----
G
K
R
G
V
L
H
G
S
Y
M
Y
L
L
Y
D
----------------
Y
P
G
V
G
P
E
H
S
Y
Y
A
D
A
G
V
A
E
Y
A
S
V
T
D
E
E
A
L
E
G
F
K
L
L
A
R
L
E
G
I
I
P
A
L
E
S
A
H
A
I
A
Y
-
A
A
K
V
V
P
E
M
D
K
---
D
Q
V
V
V
I
N
L
S
G
R
G
D
K
D
V
T
E
V
M
R
L
L
G
G
-------
25
PsiBlast_CBE
93.14
58%
-73
- C3 -
1WDW
1
TRPB1_PYRFU
D:
[2-381]
-------------
W
F
G
E
F
G
G
Q
Y
V
P
E
T
L
I
E
P
L
K
E
L
E
K
A
Y
K
R
F
K
D
D
E
E
F
N
R
Q
L
N
Y
Y
L
K
T
W
A
G
R
P
T
P
L
Y
Y
A
K
R
L
T
E
K
I
G
G
-
A
K
I
Y
L
K
R
E
D
L
V
H
G
G
A
H
K
T
N
N
A
I
G
Q
A
L
L
A
K
F
M
G
K
T
R
-
L
I
A
E
T
G
A
G
Q
H
G
V
A
T
A
M
A
G
A
L
L
G
M
K
V
D
I
Y
M
G
A
E
D
V
E
R
--
Q
K
M
N
V
F
R
M
K
L
L
G
A
N
V
I
P
-----
V
N
S
G
S
----------
R
T
L
K
D
A
I
N
E
A
L
R
D
W
V
A
T
F
E
Y
T
H
Y
L
I
G
S
V
V
G
P
H
P
Y
P
T
I
V
R
D
F
Q
S
V
I
G
R
E
A
K
A
Q
I
L
E
A
E
G
Q
L
P
D
V
I
V
A
C
V
G
G
G
S
N
A
M
G
I
F
Y
P
F
V
---
N
-
D
K--
K
V
K
L
V
G
V
E
----
A
G
G
K
G
L
E
S
G
K
H
--
S
A
S
L
N
A
----
G
Q
V
G
V
F
H
G
M
L
S
Y
F
L
Q
D
E
E
G
Q
I
K
P
T
H
S
I
A
P
G
L
D
Y
P
G
V
G
P
E
H
A
Y
L
K
K
I
Q
R
A
E
Y
V
T
V
T
D
E
E
A
L
K
A
F
H
E
L
S
R
T
E
G
I
I
P
A
L
E
S
A
H
A
V
A
Y
-
A
M
K
L
A
K
E
M
S
R
---
D
E
I
I
I
V
N
L
S
G
R
G
D
K
D
L
D
I
V
-------------
23
PsiBlast_CBE
93.07
58%
-72
- C3 -
1WDW
1
TRPB1_PYRFU
H:
[2-381]
-------------
W
F
G
E
F
G
G
Q
Y
V
P
E
T
L
I
E
P
L
K
E
L
E
K
A
Y
K
R
F
K
D
D
E
E
F
N
R
Q
L
N
Y
Y
L
K
T
W
A
G
R
P
T
P
L
Y
Y
A
K
R
L
T
E
K
I
G
G
-
A
K
I
Y
L
K
R
E
D
L
V
H
G
G
A
H
K
T
N
N
A
I
G
Q
A
L
L
A
K
F
M
G
K
T
R
-
L
I
A
E
T
G
A
G
Q
H
G
V
A
T
A
M
A
G
A
L
L
G
M
K
V
D
I
Y
M
G
A
E
D
V
E
R
--
Q
K
M
N
V
F
R
M
K
L
L
G
A
N
V
I
P
-----
V
N
S
G
S
----------
R
T
L
K
D
A
I
N
E
A
L
R
D
W
V
A
T
F
E
Y
T
H
Y
L
I
G
S
V
V
G
P
H
P
Y
P
T
I
V
R
D
F
Q
S
V
I
G
R
E
A
K
A
Q
I
L
E
A
E
G
Q
L
P
D
V
I
V
A
C
V
G
G
G
S
N
A
M
G
I
F
Y
P
F
V
---
N
-
D
K--
K
V
K
L
V
G
V
E
----
A
G
G
K
G
L
E
S
G
K
H
--
S
A
S
L
N
A
----
G
Q
V
G
V
F
H
G
M
L
S
Y
F
L
Q
D
E
E
G
Q
I
K
P
T
H
S
I
A
P
G
L
D
Y
P
G
V
G
P
E
H
A
Y
L
K
K
I
Q
R
A
E
Y
V
T
V
T
D
E
E
A
L
K
A
F
H
E
L
S
R
T
E
G
I
I
P
A
L
E
S
A
H
A
V
A
Y
-
A
M
K
L
A
K
E
M
S
R
---
D
E
I
I
I
V
N
L
S
G
R
G
D
K
D
L
D
I
V
-------------
4
PsiBlast_PDB
92.97
55%
-73
- C3 -
1X1Q
1
TRPB_THET2
A:
[25-414]
---------
D
A
R
G
R
F
G
P
Y
G
G
R
Y
V
P
E
T
L
I
P
A
L
E
E
L
E
A
A
Y
R
E
A
K
K
D
P
A
F
L
E
E
L
D
H
Y
L
R
Q
F
A
G
R
P
T
P
L
Y
H
A
K
R
L
S
E
Y
W
G
G
-
A
Q
V
F
L
K
R
E
D
L
L
H
T
G
A
H
K
I
N
N
T
L
G
Q
A
L
L
A
R
R
M
G
K
R
R
-
V
I
A
E
T
G
A
G
Q
H
G
V
S
V
A
T
V
A
A
L
F
G
L
E
C
V
V
Y
M
G
E
E
D
V
R
R
--
Q
A
L
N
V
F
R
M
K
L
L
G
A
E
V
R
P
-----
V
A
A
G
S
----------
R
T
L
K
D
A
T
N
E
A
I
R
D
W
I
T
N
V
R
T
T
F
Y
I
L
G
S
V
V
G
P
H
P
Y
P
M
M
V
R
D
F
Q
S
V
I
G
E
E
V
K
R
Q
S
L
E
L
F
G
R
L
P
D
A
L
I
A
A
V
G
G
G
S
N
A
I
G
L
F
A
P
F
A
YLP
E
-
G
---
R
P
K
L
I
G
V
E
----
A
A
G
E
G
L
S
T
G
R
H
--
A
A
S
I
G
A
----
G
K
R
G
V
L
H
G
S
Y
M
Y
L
L
Y
D
----------------
Y
P
G
V
G
P
E
H
S
Y
Y
A
D
A
G
V
A
E
Y
A
S
V
T
D
E
E
A
L
E
G
F
K
L
L
A
R
L
E
G
I
I
P
A
L
E
S
A
H
A
I
A
Y
-
A
A
K
V
V
P
E
M
D
K
---
D
Q
V
V
V
I
N
L
S
G
R
G
D
K
D
V
T
E
V
M
R
L
L
---------
22
PsiBlast_CBE
92.95
58%
-73
- C3 -
1WDW
1
TRPB1_PYRFU
J:
[2-381]
-------------
W
F
G
E
F
G
G
Q
Y
V
P
E
T
L
I
E
P
L
K
E
L
E
K
A
Y
K
R
F
K
D
D
E
E
F
N
R
Q
L
N
Y
Y
L
K
T
W
A
G
R
P
T
P
L
Y
Y
A
K
R
L
T
E
K
I
G
G
-
A
K
I
Y
L
K
R
E
D
L
V
H
G
G
A
H
K
T
N
N
A
I
G
Q
A
L
L
A
K
F
M
G
K
T
R
-
L
I
A
E
T
G
A
G
Q
H
G
V
A
T
A
M
A
G
A
L
L
G
M
K
V
D
I
Y
M
G
A
E
D
V
E
R
--
Q
K
M
N
V
F
R
M
K
L
L
G
A
N
V
I
P
-----
V
N
S
G
S
----------
R
T
L
K
D
A
I
N
E
A
L
R
D
W
V
A
T
F
E
Y
T
H
Y
L
I
G
S
V
V
G
P
H
P
Y
P
T
I
V
R
D
F
Q
S
V
I
G
R
E
A
K
A
Q
I
L
E
A
E
G
Q
L
P
D
V
I
V
A
C
V
G
G
G
S
N
A
M
G
I
F
Y
P
F
V
---
N
-
D
K--
K
V
K
L
V
G
V
E
----
A
G
G
K
G
L
E
S
G
K
H
--
S
A
S
L
N
A
----
G
Q
V
G
V
F
H
G
M
L
S
Y
F
L
Q
D
E
E
G
Q
I
K
P
T
H
S
I
A
P
G
L
D
Y
P
G
V
G
P
E
H
A
Y
L
K
K
I
Q
R
A
E
Y
V
T
V
T
D
E
E
A
L
K
A
F
H
E
L
S
R
T
E
G
I
I
P
A
L
E
S
A
H
A
V
A
Y
-
A
M
K
L
A
K
E
M
S
R
---
D
E
I
I
I
V
N
L
S
G
R
G
D
K
D
L
D
I
V
-------------
21
PsiBlast_CBE
92.92
58%
-72
- C3 -
1WDW
1
TRPB1_PYRFU
L:
[2-381]
-------------
W
F
G
E
F
G
G
Q
Y
V
P
E
T
L
I
E
P
L
K
E
L
E
K
A
Y
K
R
F
K
D
D
E
E
F
N
R
Q
L
N
Y
Y
L
K
T
W
A
G
R
P
T
P
L
Y
Y
A
K
R
L
T
E
K
I
G
G
-
A
K
I
Y
L
K
R
E
D
L
V
H
G
G
A
H
K
T
N
N
A
I
G
Q
A
L
L
A
K
F
M
G
K
T
R
-
L
I
A
E
T
G
A
G
Q
H
G
V
A
T
A
M
A
G
A
L
L
G
M
K
V
D
I
Y
M
G
A
E
D
V
E
R
--
Q
K
M
N
V
F
R
M
K
L
L
G
A
N
V
I
P
-----
V
N
S
G
S
----------
R
T
L
K
D
A
I
N
E
A
L
R
D
W
V
A
T
F
E
Y
T
H
Y
L
I
G
S
V
V
G
P
H
P
Y
P
T
I
V
R
D
F
Q
S
V
I
G
R
E
A
K
A
Q
I
L
E
A
E
G
Q
L
P
D
V
I
V
A
C
V
G
G
G
S
N
A
M
G
I
F
Y
P
F
V
---
N
-
D
K--
K
V
K
L
V
G
V
E
----
A
G
G
K
G
L
E
S
G
K
H
--
S
A
S
L
N
A
----
G
Q
V
G
V
F
H
G
M
L
S
Y
F
L
Q
D
E
E
G
Q
I
K
P
T
H
S
I
A
P
G
L
D
Y
P
G
V
G
P
E
H
A
Y
L
K
K
I
Q
R
A
E
Y
V
T
V
T
D
E
E
A
L
K
A
F
H
E
L
S
R
T
E
G
I
I
P
A
L
E
S
A
H
A
V
A
Y
-
A
M
K
L
A
K
E
M
S
R
---
D
E
I
I
I
V
N
L
S
G
R
G
D
K
D
L
D
I
V
-------------
24
PsiBlast_CBE
92.84
58%
-72
- C3 -
1WDW
1
TRPB1_PYRFU
F:
[2-381]
-------------
W
F
G
E
F
G
G
Q
Y
V
P
E
T
L
I
E
P
L
K
E
L
E
K
A
Y
K
R
F
K
D
D
E
E
F
N
R
Q
L
N
Y
Y
L
K
T
W
A
G
R
P
T
P
L
Y
Y
A
K
R
L
T
E
K
I
G
G
-
A
K
I
Y
L
K
R
E
D
L
V
H
G
G
A
H
K
T
N
N
A
I
G
Q
A
L
L
A
K
F
M
G
K
T
R
-
L
I
A
E
T
G
A
G
Q
H
G
V
A
T
A
M
A
G
A
L
L
G
M
K
V
D
I
Y
M
G
A
E
D
V
E
R
--
Q
K
M
N
V
F
R
M
K
L
L
G
A
N
V
I
P
-----
V
N
S
G
S
----------
R
T
L
K
D
A
I
N
E
A
L
R
D
W
V
A
T
F
E
Y
T
H
Y
L
I
G
S
V
V
G
P
H
P
Y
P
T
I
V
R
D
F
Q
S
V
I
G
R
E
A
K
A
Q
I
L
E
A
E
G
Q
L
P
D
V
I
V
A
C
V
G
G
G
S
N
A
M
G
I
F
Y
P
F
V
---
N
-
D
K--
K
V
K
L
V
G
V
E
----
A
G
G
K
G
L
E
S
G
K
H
--
S
A
S
L
N
A
----
G
Q
V
G
V
F
H
G
M
L
S
Y
F
L
Q
D
E
E
G
Q
I
K
P
T
H
S
I
A
P
G
L
D
Y
P
G
V
G
P
E
H
A
Y
L
K
K
I
Q
R
A
E
Y
V
T
V
T
D
E
E
A
L
K
A
F
H
E
L
S
R
T
E
G
I
I
P
A
L
E
S
A
H
A
V
A
Y
-
A
M
K
L
A
K
E
M
S
R
---
D
E
I
I
I
V
N
L
S
G
R
G
D
K
D
L
D
I
V
-------------
2
PsiBlast_PDB
92.42
58%
-71
- C3 -
1WDW
1
TRPB1_PYRFU
B:
[2-381]
-------------
W
F
G
E
F
G
G
Q
Y
V
P
E
T
L
I
E
P
L
K
E
L
E
K
A
Y
K
R
F
K
D
D
E
E
F
N
R
Q
L
N
Y
Y
L
K
T
W
A
G
R
P
T
P
L
Y
Y
A
K
R
L
T
E
K
I
G
G
-
A
K
I
Y
L
K
R
E
D
L
V
H
G
G
A
H
K
T
N
N
A
I
G
Q
A
L
L
A
K
F
M
G
K
T
R
-
L
I
A
E
T
G
A
G
Q
H
G
V
A
T
A
M
A
G
A
L
L
G
M
K
V
D
I
Y
M
G
A
E
D
V
E
R
--
Q
K
M
N
V
F
R
M
K
L
L
G
A
N
V
I
P
-----
V
N
S
G
S
----------
R
T
L
K
D
A
I
N
E
A
L
R
D
W
V
A
T
F
E
Y
T
H
Y
L
I
G
S
V
V
G
P
H
P
Y
P
T
I
V
R
D
F
Q
S
V
I
G
R
E
A
K
A
Q
I
L
E
A
E
G
Q
L
P
D
V
I
V
A
C
V
G
G
G
S
N
A
M
G
I
F
Y
P
F
V
---
N
-
D
K--
K
V
K
L
V
G
V
E
----
A
G
G
K
G
L
E
S
G
K
H
--
S
A
S
L
N
A
----
G
Q
V
G
V
F
H
G
M
L
S
Y
F
L
Q
D
E
E
G
Q
I
K
P
T
H
S
I
A
P
G
L
D
Y
P
G
V
G
P
E
H
A
Y
L
K
K
I
Q
R
A
E
Y
V
T
V
T
D
E
E
A
L
K
A
F
H
E
L
S
R
T
E
G
I
I
P
A
L
E
S
A
H
A
V
A
Y
-
A
M
K
L
A
K
E
M
S
R
---
D
E
I
I
I
V
N
L
S
G
R
G
D
K
D
L
D
I
V
-------------
27
PsiBlast_CBE
92.26
58%
-68
- C3 -
1V8Z
2
TRPB1_PYRFU
C:
[2-381]
-------------
W
F
G
E
F
G
G
Q
Y
V
P
E
T
L
I
E
P
L
K
E
L
E
K
A
Y
K
R
F
K
D
D
E
E
F
N
R
Q
L
N
Y
Y
L
K
T
W
A
G
R
P
T
P
L
Y
Y
A
K
R
L
T
E
K
I
G
G
-
A
K
I
Y
L
K
R
E
D
L
V
H
G
G
A
H
K
T
N
N
A
I
G
Q
A
L
L
A
K
F
M
G
K
T
R
-
L
I
A
E
T
G
A
G
Q
H
G
V
A
T
A
M
A
G
A
L
L
G
M
K
V
D
I
Y
M
G
A
E
D
V
E
R
--
Q
K
M
N
V
F
R
M
K
L
L
G
A
N
V
I
P
-----
V
N
S
G
S
----------
R
T
L
K
D
A
I
N
E
A
L
R
D
W
V
A
T
F
E
Y
T
H
Y
L
I
G
S
V
V
G
P
H
P
Y
P
T
I
V
R
D
F
Q
S
V
I
G
R
E
A
K
A
Q
I
L
E
A
E
G
Q
L
P
D
V
I
V
A
C
V
G
G
G
S
N
A
M
G
I
F
Y
P
F
V
---
N
-
D
K--
K
V
K
L
V
G
V
E
----
A
G
G
K
G
L
E
S
G
K
H
--
S
A
S
L
N
A
----
G
Q
V
G
V
F
H
G
M
L
S
Y
F
L
Q
D
E
E
G
Q
I
K
P
T
H
S
I
A
P
G
L
D
Y
P
G
V
G
P
E
H
A
Y
L
K
K
I
Q
R
A
E
Y
V
T
V
T
D
E
E
A
L
K
A
F
H
E
L
S
R
T
E
G
I
I
P
A
L
E
S
A
H
A
V
A
Y
-
A
M
K
L
A
K
E
M
S
R
---
D
E
I
I
I
V
N
L
S
G
R
G
D
K
D
L
D
I
V
-------------
28
PsiBlast_CBE
92.10
58%
-70
- C3 -
1V8Z
2
TRPB1_PYRFU
B:
[2-381]
-------------
W
F
G
E
F
G
G
Q
Y
V
P
E
T
L
I
E
P
L
K
E
L
E
K
A
Y
K
R
F
K
D
D
E
E
F
N
R
Q
L
N
Y
Y
L
K
T
W
A
G
R
P
T
P
L
Y
Y
A
K
R
L
T
E
K
I
G
G
-
A
K
I
Y
L
K
R
E
D
L
V
H
G
G
A
H
K
T
N
N
A
I
G
Q
A
L
L
A
K
F
M
G
K
T
R
-
L
I
A
E
T
G
A
G
Q
H
G
V
A
T
A
M
A
G
A
L
L
G
M
K
V
D
I
Y
M
G
A
E
D
V
E
R
--
Q
K
M
N
V
F
R
M
K
L
L
G
A
N
V
I
P
-----
V
N
S
G
S
----------
R
T
L
K
D
A
I
N
E
A
L
R
D
W
V
A
T
F
E
Y
T
H
Y
L
I
G
S
V
V
G
P
H
P
Y
P
T
I
V
R
D
F
Q
S
V
I
G
R
E
A
K
A
Q
I
L
E
A
E
G
Q
L
P
D
V
I
V
A
C
V
G
G
G
S
N
A
M
G
I
F
Y
P
F
V
---
N
-
D
K--
K
V
K
L
V
G
V
E
----
A
G
G
K
G
L
E
S
G
K
H
--
S
A
S
L
N
A
----
G
Q
V
G
V
F
H
G
M
L
S
Y
F
L
Q
D
E
E
G
Q
I
K
P
T
H
S
I
A
P
G
L
D
Y
P
G
V
G
P
E
H
A
Y
L
K
K
I
Q
R
A
E
Y
V
T
V
T
D
E
E
A
L
K
A
F
H
E
L
S
R
T
E
G
I
I
P
A
L
E
S
A
H
A
V
A
Y
-
A
M
K
L
A
K
E
M
S
R
---
D
E
I
I
I
V
N
L
S
G
R
G
D
K
D
L
D
I
V
-------------
26
PsiBlast_CBE
91.38
58%
-70
- C3 -
1V8Z
1
TRPB1_PYRFU
D:
[2-382]
-------------
W
F
G
E
F
G
G
Q
Y
V
P
E
T
L
I
E
P
L
K
E
L
E
K
A
Y
K
R
F
K
D
D
E
E
F
N
R
Q
L
N
Y
Y
L
K
T
W
A
G
R
P
T
P
L
Y
Y
A
K
R
L
T
E
K
I
G
G
-
A
K
I
Y
L
K
R
E
D
L
V
H
G
G
A
H
K
T
N
N
A
I
G
Q
A
L
L
A
K
F
M
G
K
T
R
-
L
I
A
E
T
G
A
G
Q
H
G
V
A
T
A
M
A
G
A
L
L
G
M
K
V
D
I
Y
M
G
A
E
D
V
E
R
--
Q
K
M
N
V
F
R
M
K
L
L
G
A
N
V
I
P
-----
V
N
S
G
S
----------
R
T
L
K
D
A
I
N
E
A
L
R
D
W
V
A
T
F
E
Y
T
H
Y
L
I
G
S
V
V
G
P
H
P
Y
P
T
I
V
R
D
F
Q
S
V
I
G
R
E
A
K
A
Q
I
L
E
A
E
G
Q
L
P
D
V
I
V
A
C
V
G
G
G
S
N
A
M
G
I
F
Y
P
F
V
---
N
-
D
K--
K
V
K
L
V
G
V
E
----
A
G
G
K
G
L
E
S
G
K
H
--
S
A
S
L
N
A
----
G
Q
V
G
V
F
H
G
M
L
S
Y
F
L
Q
D
E
E
G
Q
I
K
P
T
H
S
I
A
P
G
L
D
Y
P
G
V
G
P
E
H
A
Y
L
K
K
I
Q
R
A
E
Y
V
T
V
T
D
E
E
A
L
K
A
F
H
E
L
S
R
T
E
G
I
I
P
A
L
E
S
A
H
A
V
A
Y
-
A
M
K
L
A
K
E
M
S
R
---
D
E
I
I
I
V
N
L
S
G
R
G
D
K
D
L
D
I
V
-------------
1
PsiBlast_PDB
91.02
64%
-94
- C3 -
4NEG
5
TRPB_BACAN
A:
[23-397]
----------------------
V
P
E
T
L
M
Q
S
V
L
E
L
E
E
A
Y
K
E
A
M
E
D
E
A
F
Q
K
E
L
N
H
Y
L
K
T
Y
V
G
R
E
T
P
L
Y
F
A
E
N
M
T
E
Y
C
G
G
-
A
K
I
Y
L
K
R
E
D
L
N
H
T
G
A
H
K
I
N
N
T
I
G
Q
A
L
L
A
V
R
M
G
K
K
K
-
V
V
A
E
T
G
A
G
Q
H
G
V
A
T
A
T
V
C
A
L
L
G
L
E
C
V
I
F
M
G
E
E
D
V
R
R
--
Q
K
L
N
V
F
R
M
E
L
L
G
A
K
V
E
S
-----
V
A
A
G
------------
T
L
K
D
A
V
N
E
A
L
R
Y
W
V
S
H
V
H
D
T
H
Y
I
M
G
S
V
L
G
P
H
P
F
P
Q
I
V
R
D
F
Q
S
V
I
G
N
E
T
K
K
Q
Y
E
A
L
E
G
K
L
P
E
A
V
V
A
C
I
G
G
G
S
N
A
M
G
M
F
Y
P
F
V
---
H
-
D
E--
E
V
A
L
Y
G
V
E
----
A
A
G
---------------------------------------------------
D
Y
------
H
S
L
L
K
D
I
G
R
V
S
Y
H
S
I
T
D
D
E
A
L
E
A
F
Q
L
L
T
K
K
E
G
I
I
P
A
L
E
S
S
H
A
V
A
Y
-
A
L
K
L
A
P
Q
M
K
E
---
D
E
G
L
V
I
C
L
S
G
R
G
D
K
D
V
E
S
I
K
R
Y
M
---------
3
PsiBlast_PDB
90.84
58%
-69
- C3 -
1V8Z
2
TRPB1_PYRFU
A:
[2-381]
-------------
W
F
G
E
F
G
G
Q
Y
V
P
E
T
L
I
E
P
L
K
E
L
E
K
A
Y
K
R
F
K
D
D
E
E
F
N
R
Q
L
N
Y
Y
L
K
T
W
A
G
R
P
T
P
L
Y
Y
A
K
R
L
T
E
K
I
G
G
-
A
K
I
Y
L
K
R
E
D
L
V
H
G
G
A
H
K
T
N
N
A
I
G
Q
A
L
L
A
K
F
M
G
K
T
R
-
L
I
A
E
T
G
A
G
Q
H
G
V
A
T
A
M
A
G
A
L
L
G
M
K
V
D
I
Y
M
G
A
E
D
V
E
R
--
Q
K
M
N
V
F
R
M
K
L
L
G
A
N
V
I
P
-----
V
N
S
G
S
----------
R
T
L
K
D
A
I
N
E
A
L
R
D
W
V
A
T
F
E
Y
T
H
Y
L
I
G
S
V
V
G
P
H
P
Y
P
T
I
V
R
D
F
Q
S
V
I
G
R
E
A
K
A
Q
I
L
E
A
E
G
Q
L
P
D
V
I
V
A
C
V
G
G
G
S
N
A
M
G
I
F
Y
P
F
V
---
N
-
D
K--
K
V
K
L
V
G
V
E
----
A
G
G
K
G
L
E
S
G
K
H
--
S
A
S
L
N
A
----
G
Q
V
G
V
F
H
G
M
L
S
Y
F
L
Q
D
E
E
G
Q
I
K
P
T
H
S
I
A
P
G
L
D
Y
P
G
V
G
P
E
H
A
Y
L
K
K
I
Q
R
A
E
Y
V
T
V
T
D
E
E
A
L
K
A
F
H
E
L
S
R
T
E
G
I
I
P
A
L
E
S
A
H
A
V
A
Y
-
A
M
K
L
A
K
E
M
S
R
---
D
E
I
I
I
V
N
L
S
G
R
G
D
K
D
L
D
I
V
-------------
15
PsiBlast_PDB
90.79
50%
-67
- C3 -
1TJP
2
TRPB_SALTY
B:
[7-394]
-------------
Y
F
G
E
F
G
G
M
Y
V
P
Q
I
L
M
P
A
L
N
Q
L
E
E
A
F
V
S
A
Q
K
D
P
E
F
Q
A
Q
F
A
D
L
L
K
N
Y
A
G
R
P
T
A
L
T
K
C
Q
N
I
T
A
G
T
R
--
T
T
L
Y
L
K
R
E
D
L
L
H
G
G
A
H
K
T
N
Q
V
L
G
Q
A
L
L
A
K
R
M
G
K
S
E
-
I
I
A
E
T
G
A
G
Q
H
G
V
A
S
A
L
A
S
A
L
L
G
L
K
C
R
I
Y
M
G
A
K
D
V
E
R
--
Q
S
P
N
V
F
R
M
R
L
M
G
A
E
V
I
P
-----
V
H
S
G
S
----------
A
T
L
K
D
A
C
N
E
A
L
R
D
W
S
G
S
Y
E
T
A
H
Y
M
L
G
T
A
A
G
P
H
P
Y
P
T
I
V
R
E
F
Q
R
M
I
G
E
E
T
K
A
Q
I
L
D
K
E
G
R
L
P
D
A
V
I
A
C
V
G
G
G
S
N
A
I
G
M
F
A
D
F
I
---
N
-
D
T--
S
V
G
L
I
G
V
E
----
P
G
G
H
G
I
E
T
G
E
H
--
G
A
P
L
K
H
----
G
R
V
G
I
Y
F
G
M
K
A
P
M
M
Q
T
A
D
G
Q
I
E
E
S
Y
S
I
S
A
G
L
D
F
P
S
V
G
P
Q
H
A
Y
L
N
S
I
G
R
A
D
Y
V
S
I
T
D
D
E
A
L
E
A
F
K
T
L
C
R
H
E
G
I
I
P
A
L
E
S
S
H
A
L
A
H
A
L
K
M
M
R
E
Q
P
E
K
---
E
Q
L
L
V
V
N
L
S
G
R
G
D
K
D
I
F
T
V
H
D
I
L
K
A
R
G
-----
37
PsiBlast_CBE
90.65
50%
-66
- C3 -
1KFJ
2
TRPB_SALTY
B:
[8-395]
-------------
Y
F
G
E
F
G
G
M
Y
V
P
Q
I
L
M
P
A
L
N
Q
L
E
E
A
F
V
S
A
Q
K
D
P
E
F
Q
A
Q
F
A
D
L
L
K
N
Y
A
G
R
P
T
A
L
T
K
C
Q
N
I
T
A
G
T
R
--
T
T
L
Y
L
K
R
E
D
L
L
H
G
G
A
H
K
T
N
Q
V
L
G
Q
A
L
L
A
K
R
M
G
K
S
E
-
I
I
A
E
T
G
A
G
Q
H
G
V
A
S
A
L
A
S
A
L
L
G
L
K
C
R
I
Y
M
G
A
K
D
V
E
R
--
Q
S
P
N
V
F
R
M
R
L
M
G
A
E
V
I
P
-----
V
H
S
G
S
----------
A
T
L
K
D
A
C
N
E
A
L
R
D
W
S
G
S
Y
E
T
A
H
Y
M
L
G
T
A
A
G
P
H
P
Y
P
T
I
V
R
E
F
Q
R
M
I
G
E
E
T
K
A
Q
I
L
D
K
E
G
R
L
P
D
A
V
I
A
C
V
G
G
G
S
N
A
I
G
M
F
A
D
F
I
---
N
-
D
T--
S
V
G
L
I
G
V
E
----
P
G
G
H
G
I
E
T
G
E
H
--
G
A
P
L
K
H
----
G
R
V
G
I
Y
F
G
M
K
A
P
M
M
Q
T
A
D
G
Q
I
E
E
S
Y
S
I
S
A
G
L
D
F
P
S
V
G
P
Q
H
A
Y
L
N
S
I
G
R
A
D
Y
V
S
I
T
D
D
E
A
L
E
A
F
K
T
L
C
R
H
E
G
I
I
P
A
L
E
S
S
H
A
L
A
H
A
L
K
M
M
R
E
Q
P
E
K
---
E
Q
L
L
V
V
N
L
S
G
R
G
D
K
D
I
F
T
V
H
D
I
L
K
A
R
G
-----
14
PsiBlast_PDB
90.30
50%
-68
- C3 -
1KFB
1
TRPB_SALTY
B:
[7-394]
-------------
Y
F
G
E
F
G
G
M
Y
V
P
Q
I
L
M
P
A
L
N
Q
L
E
E
A
F
V
S
A
Q
K
D
P
E
F
Q
A
Q
F
A
D
L
L
K
N
Y
A
G
R
P
T
A
L
T
K
C
Q
N
I
T
A
G
T
R
--
T
T
L
Y
L
K
R
E
D
L
L
H
G
G
A
H
K
T
N
Q
V
L
G
Q
A
L
L
A
K
R
M
G
K
S
E
-
I
I
A
E
T
G
A
G
Q
H
G
V
A
S
A
L
A
S
A
L
L
G
L
K
C
R
I
Y
M
G
A
K
D
V
E
R
--
Q
S
P
N
V
F
R
M
R
L
M
G
A
E
V
I
P
-----
V
H
S
G
S
----------
A
T
L
K
D
A
C
N
E
A
L
R
D
W
S
G
S
Y
E
T
A
H
Y
M
L
G
T
A
A
G
P
H
P
Y
P
T
I
V
R
E
F
Q
R
M
I
G
E
E
T
K
A
Q
I
L
D
K
E
G
R
L
P
D
A
V
I
A
C
V
G
G
G
S
N
A
I
G
M
F
A
D
F
I
---
N
-
D
T--
S
V
G
L
I
G
V
E
----
P
G
G
H
G
I
E
T
G
E
H
--
G
A
P
L
K
H
----
G
R
V
G
I
Y
F
G
M
K
A
P
M
M
Q
T
A
D
G
Q
I
E
E
S
Y
S
I
S
A
G
L
D
F
P
S
V
G
P
Q
H
A
Y
L
N
S
I
G
R
A
D
Y
V
S
I
T
D
D
E
A
L
E
A
F
K
T
L
C
R
H
E
G
I
I
P
A
L
E
S
S
H
A
L
A
H
A
L
K
M
M
R
E
Q
P
E
K
---
E
Q
L
L
V
V
N
L
S
G
R
G
D
K
D
I
F
T
V
H
D
I
L
K
A
R
G
-----
63
PsiBlast_CBE
90.25
50%
-69
- C3 -
1QOQ
1
TRPB_SALTY
B:
[7-394]
-------------
Y
F
G
E
F
G
G
M
Y
V
P
Q
I
L
M
P
A
L
N
Q
L
E
E
A
F
V
S
A
Q
K
D
P
E
F
Q
A
Q
F
A
D
L
L
K
N
Y
A
G
R
P
T
A
L
T
K
C
Q
N
I
T
A
G
T
R
--
T
T
L
Y
L
K
R
E
D
L
L
H
G
G
A
H
K
T
N
Q
V
L
G
Q
A
L
L
A
K
R
M
G
K
S
E
-
I
I
A
E
T
G
A
G
Q
H
G
V
A
S
A
L
A
S
A
L
L
G
L
K
C
R
I
Y
M
G
A
K
D
V
E
R
--
Q
S
P
N
V
F
R
M
R
L
M
G
A
E
V
I
P
-----
V
H
S
G
S
----------
A
T
L
K
D
A
C
N
E
A
L
A
D
W
S
G
S
Y
E
T
A
H
Y
M
L
G
T
A
A
G
P
H
P
Y
P
T
I
V
R
E
F
Q
R
M
I
G
E
E
T
K
A
Q
I
L
D
K
E
G
R
L
P
D
A
V
I
A
C
V
G
G
G
S
N
A
I
G
M
F
A
D
F
I
---
N
-
D
T--
S
V
G
L
I
G
V
E
----
P
G
G
H
G
I
E
T
G
E
H
--
G
A
P
L
K
H
----
G
R
V
G
I
Y
F
G
M
K
A
P
M
M
Q
T
A
D
G
Q
I
E
E
S
Y
S
I
S
A
G
L
D
F
P
S
V
G
P
Q
H
A
Y
L
N
S
I
G
R
A
D
Y
V
S
I
T
D
D
E
A
L
E
A
F
K
T
L
C
R
H
E
G
I
I
P
A
L
E
S
S
H
A
L
A
H
A
L
K
M
M
R
E
Q
P
E
K
---
E
Q
L
L
V
V
N
L
S
G
R
G
D
K
D
I
F
T
V
H
D
I
L
K
A
R
G
-----
11
PsiBlast_PDB
90.13
50%
-66
- C3 -
1K3U
2
TRPB_SALTY
B:
[7-394]
-------------
Y
F
G
E
F
G
G
M
Y
V
P
Q
I
L
M
P
A
L
N
Q
L
E
E
A
F
V
S
A
Q
K
D
P
E
F
Q
A
Q
F
A
D
L
L
K
N
Y
A
G
R
P
T
A
L
T
K
C
Q
N
I
T
A
G
T
R
--
T
T
L
Y
L
K
R
E
D
L
L
H
G
G
A
H
K
T
N
Q
V
L
G
Q
A
L
L
A
K
R
M
G
K
S
E
-
I
I
A
E
T
G
A
G
Q
H
G
V
A
S
A
L
A
S
A
L
L
G
L
K
C
R
I
Y
M
G
A
K
D
V
E
R
--
Q
S
P
N
V
F
R
M
R
L
M
G
A
E
V
I
P
-----
V
H
S
G
S
----------
A
T
L
K
D
A
C
N
E
A
L
R
D
W
S
G
S
Y
E
T
A
H
Y
M
L
G
T
A
A
G
P
H
P
Y
P
T
I
V
R
E
F
Q
R
M
I
G
E
E
T
K
A
Q
I
L
D
K
E
G
R
L
P
D
A
V
I
A
C
V
G
G
G
S
N
A
I
G
M
F
A
D
F
I
---
N
-
D
T--
S
V
G
L
I
G
V
E
----
P
G
G
H
G
I
E
T
G
E
H
--
G
A
P
L
K
H
----
G
R
V
G
I
Y
F
G
M
K
A
P
M
M
Q
T
A
D
G
Q
I
E
E
S
Y
S
I
S
A
G
L
D
F
P
S
V
G
P
Q
H
A
Y
L
N
S
I
G
R
A
D
Y
V
S
I
T
D
D
E
A
L
E
A
F
K
T
L
C
R
H
E
G
I
I
P
A
L
E
S
S
H
A
L
A
H
A
L
K
M
M
R
E
Q
P
E
K
---
E
Q
L
L
V
V
N
L
S
G
R
G
D
K
D
I
F
T
V
H
D
I
L
K
A
R
G
-----
17
PsiBlast_PDB
90.04
50%
-67
- C3 -
2CLI
3
TRPB_SALTY
B:
[7-394]
-------------
Y
F
G
E
F
G
G
M
Y
V
P
Q
I
L
M
P
A
L
N
Q
L
E
E
A
F
V
S
A
Q
K
D
P
E
F
Q
A
Q
F
A
D
L
L
K
N
Y
A
G
R
P
T
A
L
T
K
C
Q
N
I
T
A
G
T
R
--
T
T
L
Y
L
K
R
E
D
L
L
H
G
G
A
H
K
T
N
Q
V
L
G
Q
A
L
L
A
K
R
M
G
K
S
E
-
I
I
A
E
T
G
A
G
Q
H
G
V
A
S
A
L
A
S
A
L
L
G
L
K
C
R
I
Y
M
G
A
K
D
V
E
R
--
Q
S
P
N
V
F
R
M
R
L
M
G
A
E
V
I
P
-----
V
H
S
G
S
----------
A
T
L
K
D
A
C
N
E
A
L
R
D
W
S
G
S
Y
E
T
A
H
Y
M
L
G
T
A
A
G
P
H
P
Y
P
T
I
V
R
E
F
Q
R
M
I
G
E
E
T
K
A
Q
I
L
D
K
E
G
R
L
P
D
A
V
I
A
C
V
G
G
G
S
N
A
I
G
M
F
A
D
F
I
---
N
-
D
T--
S
V
G
L
I
G
V
E
----
P
G
G
H
G
I
E
T
G
E
H
--
G
A
P
L
K
H
----
G
R
V
G
I
Y
F
G
M
K
A
P
M
M
Q
T
A
D
G
Q
I
E
E
S
Y
S
I
S
A
G
L
D
F
P
S
V
G
P
Q
H
A
Y
L
N
S
I
G
R
A
D
Y
V
S
I
T
D
D
E
A
L
E
A
F
K
T
L
C
R
H
E
G
I
I
P
A
L
E
S
S
H
A
L
A
H
A
L
K
M
M
R
E
Q
P
E
K
---
E
Q
L
L
V
V
N
L
S
G
R
G
D
K
D
I
F
T
V
H
D
I
L
K
A
R
G
-----
53
PsiBlast_CBE
90.00
50%
-66
- C3 -
2CLH
2
TRPB_SALTY
B:
[7-394]
-------------
Y
F
G
E
F
G
G
M
Y
V
P
Q
I
L
M
P
A
L
N
Q
L
E
E
A
F
V
R
A
Q
K
D
P
E
F
Q
A
Q
F
A
D
L
L
K
N
Y
A
G
R
P
T
A
L
T
K
C
Q
N
I
T
A
G
T
R
--
T
T
L
Y
L
K
R
E
D
L
L
H
G
G
A
H
K
T
N
Q
V
L
G
Q
A
L
L
A
K
R
M
G
K
S
E
-
I
I
A
E
T
G
A
G
Q
H
G
V
A
S
A
L
A
S
A
L
L
G
L
K
C
R
I
Y
M
G
A
K
D
V
E
R
--
Q
S
P
N
V
F
R
M
R
L
M
G
A
E
V
I
P
-----
V
H
S
G
S
----------
A
T
L
K
D
A
C
N
E
A
L
R
D
W
S
G
S
Y
E
T
A
H
Y
M
L
G
T
A
A
G
P
H
P
Y
P
T
I
V
R
E
F
Q
R
M
I
G
E
E
T
K
A
Q
I
L
D
K
E
G
R
L
P
D
A
V
I
A
C
V
G
G
G
S
N
A
I
G
M
F
A
D
F
I
---
N
-
D
T--
S
V
G
L
I
G
V
E
----
P
G
G
H
G
I
E
T
G
E
H
--
G
A
P
L
K
H
----
G
R
V
G
I
Y
F
G
M
K
A
P
M
M
Q
T
A
D
G
Q
I
E
E
S
Y
S
I
S
A
G
L
D
F
P
S
V
G
P
Q
H
A
Y
L
N
S
I
G
R
A
D
Y
V
S
I
T
D
D
E
A
L
E
A
F
K
T
L
C
R
H
E
G
I
I
P
A
L
E
S
S
H
A
L
A
H
A
L
K
M
M
R
E
Q
P
E
K
---
E
Q
L
L
V
V
N
L
S
G
R
G
D
K
D
I
F
T
V
H
D
I
L
K
A
R
G
-----
42
PsiBlast_CBE
89.94
50%
-66
- C3 -
1KFE
2
TRPB_SALTY
B:
[7-394]
-------------
Y
F
G
E
F
G
G
M
Y
V
P
Q
I
L
M
P
A
L
N
Q
L
E
E
A
F
V
S
A
Q
K
D
P
E
F
Q
A
Q
F
A
D
L
L
K
N
Y
A
G
R
P
T
A
L
T
K
C
Q
N
I
T
A
G
T
R
--
T
T
L
Y
L
K
R
E
D
L
L
H
G
G
A
H
K
T
N
Q
V
L
G
Q
A
L
L
A
K
R
M
G
K
S
E
-
I
I
A
E
T
G
A
G
Q
H
G
V
A
S
A
L
A
S
A
L
L
G
L
K
C
R
I
Y
M
G
A
K
D
V
E
R
--
Q
S
P
N
V
F
R
M
R
L
M
G
A
E
V
I
P
-----
V
H
S
G
S
----------
A
T
L
K
D
A
C
N
E
A
L
R
D
W
S
G
S
Y
E
T
A
H
Y
M
L
G
T
A
A
G
P
H
P
Y
P
T
I
V
R
E
F
Q
R
M
I
G
E
E
T
K
A
Q
I
L
D
K
E
G
R
L
P
D
A
V
I
A
C
V
G
G
G
S
N
A
I
G
M
F
A
D
F
I
---
N
-
D
T--
S
V
G
L
I
G
V
E
----
P
G
G
H
G
I
E
T
G
E
H
--
G
A
P
L
K
H
----
G
R
V
G
I
Y
F
G
M
K
A
P
M
M
Q
T
A
D
G
Q
I
E
E
S
Y
S
I
S
A
G
L
D
F
P
S
V
G
P
Q
H
A
Y
L
N
S
I
G
R
A
D
Y
V
S
I
T
D
D
E
A
L
E
A
F
K
T
L
C
R
H
E
G
I
I
P
A
L
E
S
S
H
A
L
A
H
A
L
K
M
M
R
E
Q
P
E
K
---
E
Q
L
L
V
V
N
L
S
G
R
G
D
K
D
I
F
T
V
H
D
I
L
K
A
R
G
-----
12
PsiBlast_PDB
89.76
50%
-64
- C3 -
1K7E
2
TRPB_SALTY
B:
[7-393]
-------------
Y
F
G
E
F
G
G
M
Y
V
P
Q
I
L
M
P
A
L
N
Q
L
E
E
A
F
V
S
A
Q
K
D
P
E
F
Q
A
Q
F
A
D
L
L
K
N
Y
A
G
R
P
T
A
L
T
K
C
Q
N
I
T
A
G
T
R
--
T
T
L
Y
L
K
R
E
D
L
L
H
G
G
A
H
K
T
N
Q
V
L
G
Q
A
L
L
A
K
R
M
G
K
S
E
-
I
I
A
E
T
G
A
G
Q
H
G
V
A
S
A
L
A
S
A
L
L
G
L
K
C
R
I
Y
M
G
A
K
D
V
E
R
--
Q
S
P
N
V
F
R
M
R
L
M
G
A
E
V
I
P
-----
V
H
S
G
S
----------
A
T
L
K
D
A
C
N
E
A
L
R
D
W
S
G
S
Y
E
T
A
H
Y
M
L
G
T
A
A
G
P
H
P
Y
P
T
I
V
R
E
F
Q
R
M
I
G
E
E
T
K
A
Q
I
L
D
K
E
G
R
L
P
D
A
V
I
A
C
V
G
G
G
S
N
A
I
G
M
F
A
D
F
I
---
N
-
D
T--
S
V
G
L
I
G
V
E
----
P
G
G
H
G
I
E
T
G
E
H
--
G
A
P
L
K
H
----
G
R
V
G
I
Y
F
G
M
K
A
P
M
M
Q
T
A
D
G
Q
I
E
E
S
Y
S
I
S
A
G
L
D
F
P
S
V
G
P
Q
H
A
Y
L
N
S
I
G
R
A
D
Y
V
S
I
T
D
D
E
A
L
E
A
F
K
T
L
C
R
H
E
G
I
I
P
A
L
E
S
S
H
A
L
A
H
A
L
K
M
M
R
E
Q
P
E
K
---
E
Q
L
L
V
V
N
L
S
G
R
G
D
K
D
I
F
T
V
H
D
I
L
K
A
R
------
34
PsiBlast_CBE
89.68
50%
-63
- C3 -
4HN4
9
TRPB_SALTY
B:
[8-395]
-------------
Y
F
G
E
F
G
G
M
Y
V
P
Q
I
L
M
P
A
L
N
Q
L
E
E
A
F
V
S
A
Q
K
D
P
E
F
Q
A
Q
F
A
D
L
L
K
N
Y
A
G
R
P
T
A
L
T
K
C
Q
N
I
T
A
G
T
R
--
T
T
L
Y
L
K
R
E
D
L
L
H
G
G
A
H
K
T
N
Q
V
L
G
Q
A
L
L
A
K
R
M
G
K
S
E
-
I
I
A
E
T
G
A
G
Q
H
G
V
A
S
A
L
A
S
A
L
L
G
L
K
C
R
I
Y
M
G
A
K
D
V
E
R
--
Q
S
P
N
V
F
R
M
R
L
M
G
A
E
V
I
P
-----
V
H
S
G
S
----------
A
T
L
K
D
A
C
N
E
A
L
R
D
W
S
G
S
Y
E
T
A
H
Y
M
L
G
T
A
A
G
P
H
P
Y
P
T
I
V
R
E
F
Q
R
M
I
G
E
E
T
K
A
Q
I
L
D
K
E
G
R
L
P
D
A
V
I
A
C
V
G
G
G
S
N
A
I
G
M
F
A
D
F
I
---
N
-
D
T--
S
V
G
L
I
G
V
E
----
P
G
G
H
G
I
E
T
G
E
H
--
G
A
P
L
K
H
----
G
R
V
G
I
Y
F
G
M
K
A
P
M
M
Q
T
A
D
G
Q
I
E
E
S
Y
S
I
S
A
G
L
D
F
P
S
V
G
P
Q
H
A
Y
L
N
S
I
G
R
A
D
Y
V
S
I
T
D
D
E
A
L
E
A
F
K
T
L
C
R
H
E
G
I
I
P
A
L
E
S
S
H
A
L
A
H
A
L
K
M
M
R
E
Q
P
E
K
---
E
Q
L
L
V
V
N
L
S
G
R
G
D
K
D
I
F
T
V
H
D
I
L
K
A
R
G
-----
54
PsiBlast_CBE
89.63
50%
-67
- C3 -
2CLF
4
TRPB_SALTY
B:
[7-394]
-------------
Y
F
G
E
F
G
G
M
Y
V
P
Q
I
L
M
P
A
L
N
Q
L
E
E
A
F
V
R
A
Q
K
D
P
E
F
Q
A
Q
F
A
D
L
L
K
N
Y
A
G
R
P
T
A
L
T
K
C
Q
N
I
T
A
G
T
R
--
T
T
L
Y
L
K
R
E
D
L
L
H
G
G
A
H
K
T
N
Q
V
L
G
Q
A
L
L
A
K
R
M
G
K
S
E
-
I
I
A
E
T
G
A
G
Q
H
G
V
A
S
A
L
A
S
A
L
L
G
L
K
C
R
I
Y
M
G
A
K
D
V
E
R
--
Q
S
P
N
V
F
R
M
R
L
M
G
A
E
V
I
P
-----
V
H
S
G
S
----------
A
T
L
K
D
A
C
N
E
A
L
R
D
W
S
G
S
Y
E
T
A
H
Y
M
L
G
T
A
A
G
P
H
P
Y
P
T
I
V
R
E
F
Q
R
M
I
G
E
E
T
K
A
Q
I
L
D
K
E
G
R
L
P
D
A
V
I
A
C
V
G
G
G
S
N
A
I
G
M
F
A
D
F
I
---
N
-
D
T--
S
V
G
L
I
G
V
E
----
P
G
G
H
G
I
E
T
G
E
H
--
G
A
P
L
K
H
----
G
R
V
G
I
Y
F
G
M
K
A
P
M
M
Q
T
A
D
G
Q
I
E
E
S
Y
S
I
S
A
G
L
D
F
P
S
V
G
P
Q
H
A
Y
L
N
S
I
G
R
A
D
Y
V
S
I
T
D
D
E
A
L
E
A
F
K
T
L
C
R
H
E
G
I
I
P
A
L
E
S
S
H
A
L
A
H
A
L
K
M
M
R
E
Q
P
E
K
---
E
Q
L
L
V
V
N
L
S
G
R
G
D
K
D
I
F
T
V
H
D
I
L
K
A
R
G
-----
36
PsiBlast_CBE
89.58
50%
-66
- C3 -
1KFK
2
TRPB_SALTY
B:
[8-393]
-------------
Y
F
G
E
F
G
G
M
Y
V
P
Q
I
L
M
P
A
L
N
Q
L
E
E
A
F
V
S
A
Q
K
D
P
E
F
Q
A
Q
F
A
D
L
L
K
N
Y
A
G
R
P
T
A
L
T
K
C
Q
N
I
T
A
G
T
R
--
T
T
L
Y
L
K
R
E
D
L
L
H
G
G
A
H
K
T
N
Q
V
L
G
Q
A
L
L
A
K
R
M
G
K
S
E
-
I
I
A
E
T
G
A
G
Q
H
G
V
A
S
A
L
A
S
A
L
L
G
L
K
C
R
I
Y
M
G
A
K
D
V
E
R
--
Q
S
P
N
V
F
R
M
R
L
M
G
A
E
V
I
P
-----
V
H
S
G
S
----------
A
T
L
K
D
A
C
N
E
A
L
R
D
W
S
G
S
Y
E
T
A
H
Y
M
L
G
T
A
A
G
P
H
P
Y
P
T
I
V
R
E
F
Q
R
M
I
G
E
E
T
K
A
Q
I
L
D
K
E
G
R
L
P
D
A
V
I
A
C
V
G
G
G
S
N
A
I
G
M
F
A
D
F
I
---
N
-
D
T--
S
V
G
L
I
G
V
E
----
P
G
G
H
G
I
E
T
G
E
H
--
G
A
P
L
K
H
----
G
R
V
G
I
Y
F
G
M
K
A
P
M
M
Q
T
A
D
G
Q
I
E
E
S
Y
S
I
S
A
G
L
D
F
P
S
V
G
P
Q
H
A
Y
L
N
S
I
G
R
A
D
Y
V
S
I
T
D
D
E
A
L
E
A
F
K
T
L
C
R
H
E
G
I
I
P
A
L
E
S
S
H
A
L
A
H
A
L
K
M
M
R
E
Q
P
E
K
---
E
Q
L
L
V
V
N
L
S
G
R
G
D
K
D
I
F
T
V
H
D
I
L
K
A
-------
38
PsiBlast_CBE
89.56
50%
-66
- C3 -
1KFC
2
TRPB_SALTY
B:
[8-393]
-------------
Y
F
G
E
F
G
G
M
Y
V
P
Q
I
L
M
P
A
L
N
Q
L
E
E
A
F
V
S
A
Q
K
D
P
E
F
Q
A
Q
F
A
D
L
L
K
N
Y
A
G
R
P
T
A
L
T
K
C
Q
N
I
T
A
G
T
R
--
T
T
L
Y
L
K
R
E
D
L
L
H
G
G
A
H
K
T
N
Q
V
L
G
Q
A
L
L
A
K
R
M
G
K
S
E
-
I
I
A
E
T
G
A
G
Q
H
G
V
A
S
A
L
A
S
A
L
L
G
L
K
C
R
I
Y
M
G
A
K
D
V
E
R
--
Q
S
P
N
V
F
R
M
R
L
M
G
A
E
V
I
P
-----
V
H
S
G
S
----------
A
T
L
K
D
A
C
N
E
A
L
R
D
W
S
G
S
Y
E
T
A
H
Y
M
L
G
T
A
A
G
P
H
P
Y
P
T
I
V
R
E
F
Q
R
M
I
G
E
E
T
K
A
Q
I
L
D
K
E
G
R
L
P
D
A
V
I
A
C
V
G
G
G
S
N
A
I
G
M
F
A
D
F
I
---
N
-
D
T--
S
V
G
L
I
G
V
E
----
P
G
G
H
G
I
E
T
G
E
H
--
G
A
P
L
K
H
----
G
R
V
G
I
Y
F
G
M
K
A
P
M
M
Q
T
A
D
G
Q
I
E
E
S
Y
S
I
S
A
G
L
D
F
P
S
V
G
P
Q
H
A
Y
L
N
S
I
G
R
A
D
Y
V
S
I
T
D
D
E
A
L
E
A
F
K
T
L
C
R
H
E
G
I
I
P
A
L
E
S
S
H
A
L
A
H
A
L
K
M
M
R
E
Q
P
E
K
---
E
Q
L
L
V
V
N
L
S
G
R
G
D
K
D
I
F
T
V
H
D
I
L
K
A
-------
35
PsiBlast_CBE
89.54
50%
-67
- C3 -
2RH9
2
TRPB_SALTY
B:
[8-395]
-------------
Y
F
G
E
F
G
G
M
Y
V
P
Q
I
L
M
P
A
L
N
Q
L
E
E
A
F
V
S
A
Q
K
D
P
E
F
Q
A
Q
F
A
D
L
L
K
N
Y
A
G
R
P
T
A
L
T
K
C
Q
N
I
T
A
G
T
R
--
T
T
L
Y
L
K
R
E
D
L
L
H
G
G
A
H
K
T
N
Q
V
L
G
Q
A
L
L
A
K
R
M
G
K
S
E
-
I
I
A
E
T
G
A
G
Q
H
G
V
A
S
A
L
A
S
A
L
L
G
L
K
C
R
I
Y
M
G
A
K
D
V
E
R
--
Q
S
P
N
V
F
R
M
R
L
M
G
A
E
V
I
P
-----
V
H
S
G
S
----------
A
T
L
K
D
A
C
N
E
A
L
R
D
W
S
G
S
Y
E
T
A
H
Y
M
L
G
T
A
A
G
P
H
P
Y
P
T
I
V
R
E
F
Q
R
M
I
G
E
E
T
K
A
Q
I
L
D
K
E
G
R
L
P
D
A
V
I
A
C
V
G
G
G
S
N
A
I
G
M
F
A
D
F
I
---
N
-
D
T--
S
V
G
L
I
G
V
E
----
P
G
G
H
G
I
E
T
G
E
H
--
G
A
P
L
K
H
----
G
R
V
G
I
Y
F
G
M
K
A
P
M
M
Q
T
A
D
G
Q
I
E
E
S
Y
S
I
S
A
G
L
D
F
P
S
V
G
P
Q
H
A
Y
L
N
S
I
G
R
A
D
Y
V
S
I
T
D
D
E
A
L
E
A
F
K
T
L
C
R
H
E
G
I
I
P
A
L
E
S
S
H
A
L
A
H
A
L
K
M
M
R
E
Q
P
E
K
---
E
Q
L
L
V
V
N
L
S
G
R
G
D
K
D
I
F
T
V
H
D
I
L
K
A
R
G
-----
65
PsiBlast_CBE
89.52
49%
-68
- C3 -
2DH5
4
TRPB_ECOLI
A:
[8-395]
-------------
Y
F
G
E
F
G
G
M
Y
V
P
Q
I
L
M
P
A
L
R
Q
L
E
E
A
F
V
S
A
Q
K
D
P
E
F
Q
A
Q
F
N
D
L
L
K
N
Y
A
G
R
P
T
A
L
T
K
C
Q
N
I
T
A
G
T
N
--
T
T
L
Y
L
K
R
E
D
L
L
H
G
G
A
H
K
T
N
Q
V
L
G
Q
A
L
L
A
K
R
M
G
K
T
E
-
I
I
A
E
T
G
A
G
Q
H
G
V
A
S
A
L
A
S
A
L
L
G
L
K
C
R
I
Y
M
G
A
K
D
V
E
R
--
Q
S
P
N
V
F
R
M
R
L
M
G
A
E
V
I
P
-----
V
H
S
G
S
----------
A
T
L
K
D
A
C
N
E
A
L
R
D
W
S
G
S
Y
E
T
A
H
Y
M
L
G
T
A
A
G
P
H
P
Y
P
T
I
V
R
E
F
Q
R
M
I
G
E
E
T
K
A
Q
I
L
E
R
E
G
R
L
P
D
A
V
I
A
C
V
G
G
G
S
N
A
I
G
M
F
A
D
F
I
---
N
-
E
T--
N
V
G
L
I
G
V
E
----
P
G
G
H
G
I
E
T
G
E
H
--
G
A
P
L
K
H
----
G
R
V
G
I
Y
F
G
M
K
A
P
M
M
Q
T
E
--
Q
I
E
E
S
Y
S
I
S
A
G
L
D
F
P
S
V
G
P
Q
H
A
Y
L
N
S
T
G
R
A
D
Y
V
S
I
T
D
D
E
A
L
E
A
F
K
T
L
C
L
H
E
G
I
I
P
A
L
E
S
S
H
A
L
A
H
A
L
K
M
M
R
E
N
P
D
K
---
E
Q
L
L
V
V
N
L
S
G
R
G
D
K
D
I
F
T
V
H
D
I
L
K
A
R
G
-----
55
PsiBlast_CBE
89.50
50%
-68
- C3 -
2CLE
3
TRPB_SALTY
B:
[7-394]
-------------
Y
F
G
E
F
G
G
M
Y
V
P
Q
I
L
M
P
A
L
N
Q
L
E
E
A
F
V
R
A
Q
K
D
P
E
F
Q
A
Q
F
A
D
L
L
K
N
Y
A
G
R
P
T
A
L
T
K
C
Q
N
I
T
A
G
T
R
--
T
T
L
Y
L
K
R
E
D
L
L
H
G
G
A
H
K
T
N
Q
V
L
G
Q
A
L
L
A
K
R
M
G
K
S
E
-
I
I
A
E
T
G
A
G
Q
H
G
V
A
S
A
L
A
S
A
L
L
G
L
K
C
R
I
Y
M
G
A
K
D
V
E
R
--
Q
S
P
N
V
F
R
M
R
L
M
G
A
E
V
I
P
-----
V
H
S
G
S
----------
A
T
L
K
D
A
C
N
E
A
L
R
D
W
S
G
S
Y
E
T
A
H
Y
M
L
G
T
A
A
G
P
H
P
Y
P
T
I
V
R
E
F
Q
R
M
I
G
E
E
T
K
A
Q
I
L
D
K
E
G
R
L
P
D
A
V
I
A
C
V
G
G
G
S
N
A
I
G
M
F
A
D
F
I
---
N
-
D
T--
S
V
G
L
I
G
V
E
----
P
G
G
H
G
I
E
T
G
E
H
--
G
A
P
L
K
H
----
G
R
V
G
I
Y
F
G
M
K
A
P
M
M
Q
T
A
D
G
Q
I
E
E
S
Y
S
I
S
A
G
L
D
F
P
S
V
G
P
Q
H
A
Y
L
N
S
I
G
R
A
D
Y
V
S
I
T
D
D
E
A
L
E
A
F
K
T
L
C
R
H
E
G
I
I
P
A
L
E
S
S
H
A
L
A
H
A
L
K
M
M
R
E
Q
P
E
K
---
E
Q
L
L
V
V
N
L
S
G
R
G
D
K
D
I
F
T
V
H
D
I
L
K
A
R
G
-----
32
PsiBlast_CBE
89.38
50%
-63
- C3 -
4HPX
13
TRPB_SALTY
B:
[8-395]
-------------
Y
F
G
E
F
G
G
M
Y
V
P
Q
I
L
M
P
A
L
N
Q
L
E
E
A
F
V
S
A
Q
K
D
P
E
F
Q
A
Q
F
A
D
L
L
K
N
Y
A
G
R
P
T
A
L
T
K
C
Q
N
I
T
A
G
T
R
--
T
T
L
Y
L
K
R
E
D
L
L
H
G
G
A
H
K
T
N
Q
V
L
G
Q
A
L
L
A
K
R
M
G
K
S
E
-
I
I
A
E
T
G
A
G
Q
H
G
V
A
S
A
L
A
S
A
L
L
G
L
K
C
R
I
Y
M
G
A
K
D
V
E
R
--
Q
S
P
N
V
F
R
M
R
L
M
G
A
E
V
I
P
-----
V
H
S
G
S
----------
A
T
L
K
D
A
C
N
E
A
L
R
D
W
S
G
S
Y
E
T
A
H
Y
M
L
G
T
A
A
G
P
H
P
Y
P
T
I
V
R
E
F
Q
R
M
I
G
E
E
T
K
A
Q
I
L
D
K
E
G
R
L
P
D
A
V
I
A
C
V
G
G
G
S
N
A
I
G
M
F
A
D
F
I
---
N
-
D
T--
S
V
G
L
I
G
V
E
----
P
G
G
H
G
I
E
T
G
E
H
--
G
A
P
L
K
H
----
G
R
V
G
I
Y
F
G
M
K
A
P
M
M
Q
T
A
D
G
Q
I
E
E
S
Y
S
I
S
A
G
L
D
F
P
S
V
G
P
Q
H
A
Y
L
N
S
I
G
R
A
D
Y
V
S
I
T
D
D
E
A
L
E
A
F
K
T
L
C
R
H
E
G
I
I
P
A
L
E
S
S
H
A
L
A
H
A
L
K
M
M
R
E
Q
P
E
K
---
E
Q
L
L
V
V
N
L
S
G
R
G
D
K
D
I
F
T
V
H
D
I
L
K
A
R
G
-----
57
PsiBlast_CBE
89.30
50%
-68
- C3 -
1K8Z
2
TRPB_SALTY
B:
[7-394]
-------------
Y
F
G
E
F
G
G
M
Y
V
P
Q
I
L
M
P
A
L
N
Q
L
E
E
A
F
V
S
A
Q
K
D
P
E
F
Q
A
Q
F
A
D
L
L
K
N
Y
A
G
R
P
T
A
L
T
K
C
Q
N
I
T
A
G
T
R
--
T
T
L
Y
L
K
R
E
D
L
L
H
G
G
A
H
K
T
N
Q
V
L
G
Q
A
L
L
A
K
R
M
G
K
S
E
-
I
I
A
E
T
G
A
G
Q
H
G
V
A
S
A
L
A
S
A
L
L
G
L
K
C
R
I
Y
M
G
A
K
D
V
E
R
--
Q
S
P
N
V
F
R
M
R
L
M
G
A
E
V
I
P
-----
V
H
S
G
S
----------
A
T
L
K
D
A
C
N
E
A
L
R
D
W
P
G
S
Y
E
T
A
H
Y
M
L
G
T
A
A
G
P
H
P
Y
P
T
I
V
R
E
F
Q
R
M
I
G
E
E
T
K
A
Q
I
L
D
K
E
G
R
L
P
D
A
V
I
A
C
V
G
G
G
S
N
A
I
G
M
F
A
D
F
I
---
N
-
D
T--
S
V
G
L
I
G
V
E
----
P
G
G
H
G
I
E
T
G
E
H
--
G
A
P
L
K
H
----
G
R
V
G
I
Y
F
G
M
K
A
P
M
M
Q
T
A
D
G
Q
I
E
E
S
Y
S
I
S
A
G
L
D
F
P
S
V
G
P
Q
H
A
Y
L
N
S
I
G
R
A
D
Y
V
S
I
T
D
D
E
A
L
E
A
F
K
T
L
C
R
H
E
G
I
I
P
A
L
E
S
S
H
A
L
A
H
A
L
K
M
M
R
E
Q
P
E
K
---
E
Q
L
L
V
V
N
L
S
G
R
G
D
K
D
I
F
T
V
H
D
I
L
K
A
R
G
-----
10
PsiBlast_PDB
89.23
50%
-67
- C3 -
1QOP
2
TRPB_SALTY
B:
[7-390]
-------------
Y
F
G
E
F
G
G
M
Y
V
P
Q
I
L
M
P
A
L
N
Q
L
E
E
A
F
V
S
A
Q
K
D
P
E
F
Q
A
Q
F
A
D
L
L
K
N
Y
A
G
R
P
T
A
L
T
K
C
Q
N
I
T
A
G
T
R
--
T
T
L
Y
L
K
R
E
D
L
L
H
G
G
A
H
K
T
N
Q
V
L
G
Q
A
L
L
A
K
R
M
G
K
S
E
-
I
I
A
E
T
G
A
G
Q
H
G
V
A
S
A
L
A
S
A
L
L
G
L
K
C
R
I
Y
M
G
A
K
D
V
E
R
--
Q
S
P
N
V
F
R
M
R
L
M
G
A
E
V
I
P
-----
V
H
S
G
S
----------
A
T
L
K
D
A
C
N
E
A
L
R
D
W
S
G
S
Y
E
T
A
H
Y
M
L
G
T
A
A
G
P
H
P
Y
P
T
I
V
R
E
F
Q
R
M
I
G
E
E
T
K
A
Q
I
L
D
K
E
G
R
L
P
D
A
V
I
A
C
V
G
G
G
S
N
A
I
G
M
F
A
D
F
I
---
N
-
D
T--
S
V
G
L
I
G
V
E
----
P
G
G
H
G
I
E
T
G
E
H
--
G
A
P
L
K
H
----
G
R
V
G
I
Y
F
G
M
K
A
P
M
M
Q
T
A
D
G
Q
I
E
E
S
Y
S
I
S
A
G
L
D
F
P
S
V
G
P
Q
H
A
Y
L
N
S
I
G
R
A
D
Y
V
S
I
T
D
D
E
A
L
E
A
F
K
T
L
C
R
H
E
G
I
I
P
A
L
E
S
S
H
A
L
A
H
A
L
K
M
M
R
E
Q
P
E
K
---
E
Q
L
L
V
V
N
L
S
G
R
G
D
K
D
I
F
T
V
H
D
I
L
---------
68
PsiBlast_CBE
89.19
50%
-71
* C3 *
1FUY
2
TRPB_SALTY
B:
[7-393]
-------------
Y
F
G
E
F
G
G
M
Y
V
P
Q
I
L
M
P
A
L
N
Q
L
E
E
A
F
V
S
A
Q
K
D
P
E
F
Q
A
Q
F
A
D
L
L
K
N
Y
A
G
R
P
T
A
L
T
K
C
Q
N
I
T
A
G
T
R
--
T
T
L
Y
L
K
R
E
D
L
L
H
G
G
A
H
K
T
N
Q
V
L
G
Q
A
L
L
A
K
R
M
G
K
S
E
-
I
I
A
E
T
G
A
G
Q
H
G
V
A
S
A
L
A
S
A
L
L
G
L
K
C
R
I
Y
M
G
A
K
D
V
E
R
--
Q
S
P
N
V
F
R
M
R
L
M
G
A
E
V
I
P
-----
V
H
S
G
S
----------
A
T
L
K
D
L
W
N
E
A
L
R
D
W
S
G
S
Y
E
T
A
H
Y
M
L
G
T
A
A
G
P
H
P
Y
P
T
I
V
R
E
F
Q
R
M
I
G
E
E
T
K
A
Q
I
L
D
K
E
G
R
L
P
D
A
V
I
A
C
V
G
G
G
S
N
A
I
G
M
F
A
D
F
I
---
N
-
D
T--
S
V
G
L
I
G
V
E
----
P
G
G
H
G
I
E
T
G
E
H
--
G
A
P
L
K
H
----
G
R
V
G
I
Y
F
G
M
K
A
P
M
M
Q
T
A
D
G
Q
I
E
E
S
Y
S
I
S
A
G
L
D
F
P
S
V
G
P
Q
H
A
Y
L
N
S
I
G
R
A
D
Y
V
S
I
T
D
D
E
A
L
E
A
F
K
T
L
C
R
H
E
G
I
I
P
A
L
E
S
S
H
A
L
A
H
A
L
K
M
M
R
E
Q
P
E
K
---
E
Q
L
L
V
V
N
L
S
G
R
G
D
K
D
I
F
T
V
H
D
I
L
K
A
R
------
18
PsiBlast_PDB
89.19
50%
-67
- C3 -
2CLK
2
TRPB_SALTY
B:
[7-390]
-------------
Y
F
G
E
F
G
G
M
Y
V
P
Q
I
L
M
P
A
L
N
Q
L
E
E
A
F
V
S
A
Q
K
D
P
E
F
Q
A
Q
F
A
D
L
L
K
N
Y
A
G
R
P
T
A
L
T
K
C
Q
N
I
T
A
G
T
R
--
T
T
L
Y
L
K
R
E
D
L
L
H
G
G
A
H
K
T
N
Q
V
L
G
Q
A
L
L
A
K
R
M
G
K
S
E
-
I
I
A
E
T
G
A
G
Q
H
G
V
A
S
A
L
A
S
A
L
L
G
L
K
C
R
I
Y
M
G
A
K
D
V
E
R
--
Q
S
P
N
V
F
R
M
R
L
M
G
A
E
V
I
P
-----
V
H
S
G
S
----------
A
T
L
K
D
A
C
N
E
A
L
R
D
W
S
G
S
Y
E
T
A
H
Y
M
L
G
T
A
A
G
P
H
P
Y
P
T
I
V
R
E
F
Q
R
M
I
G
E
E
T
K
A
Q
I
L
D
K
E
G
R
L
P
D
A
V
I
A
C
V
G
G
G
S
N
A
I
G
M
F
A
D
F
I
---
N
-
D
T--
S
V
G
L
I
G
V
E
----
P
G
G
H
G
I
E
T
G
E
H
--
G
A
P
L
K
H
----
G
R
V
G
I
Y
F
G
M
K
A
P
M
M
Q
T
A
D
G
Q
I
E
E
S
Y
S
I
S
A
G
L
D
F
P
S
V
G
P
Q
H
A
Y
L
N
S
I
G
R
A
D
Y
V
S
I
T
D
D
E
A
L
E
A
F
K
T
L
C
R
H
E
G
I
I
P
A
L
E
S
S
H
A
L
A
H
A
L
K
M
M
R
E
Q
P
E
K
---
E
Q
L
L
V
V
N
L
S
G
R
G
D
K
D
I
F
T
V
H
D
I
L
---------
16
PsiBlast_PDB
89.19
50%
-67
- C3 -
1WBJ
2
TRPB_SALTY
B:
[7-390]
-------------
Y
F
G
E
F
G
G
M
Y
V
P
Q
I
L
M
P
A
L
N
Q
L
E
E
A
F
V
S
A
Q
K
D
P
E
F
Q
A
Q
F
A
D
L
L
K
N
Y
A
G
R
P
T
A
L
T
K
C
Q
N
I
T
A
G
T
R
--
T
T
L
Y
L
K
R
E
D
L
L
H
G
G
A
H
K
T
N
Q
V
L
G
Q
A
L
L
A
K
R
M
G
K
S
E
-
I
I
A
E
T
G
A
G
Q
H
G
V
A
S
A
L
A
S
A
L
L
G
L
K
C
R
I
Y
M
G
A
K
D
V
E
R
--
Q
S
P
N
V
F
R
M
R
L
M
G
A
E
V
I
P
-----
V
H
S
G
S
----------
A
T
L
K
D
A
C
N
E
A
L
R
D
W
S
G
S
Y
E
T
A
H
Y
M
L
G
T
A
A
G
P
H
P
Y
P
T
I
V
R
E
F
Q
R
M
I
G
E
E
T
K
A
Q
I
L
D
K
E
G
R
L
P
D
A
V
I
A
C
V
G
G
G
S
N
A
I
G
M
F
A
D
F
I
---
N
-
D
T--
S
V
G
L
I
G
V
E
----
P
G
G
H
G
I
E
T
G
E
H
--
G
A
P
L
K
H
----
G
R
V
G
I
Y
F
G
M
K
A
P
M
M
Q
T
A
D
G
Q
I
E
E
S
Y
S
I
S
A
G
L
D
F
P
S
V
G
P
Q
H
A
Y
L
N
S
I
G
R
A
D
Y
V
S
I
T
D
D
E
A
L
E
A
F
K
T
L
C
R
H
E
G
I
I
P
A
L
E
S
S
H
A
L
A
H
A
L
K
M
M
R
E
Q
P
E
K
---
E
Q
L
L
V
V
N
L
S
G
R
G
D
K
D
I
F
T
V
H
D
I
L
---------
31
PsiBlast_CBE
89.18
50%
-67
- C3 -
4HT3
20
TRPB_SALTY
B:
[8-394]
-------------
Y
F
G
E
F
G
G
M
Y
V
P
Q
I
L
M
P
A
L
N
Q
L
E
E
A
F
V
S
A
Q
K
D
P
E
F
Q
A
Q
F
A
D
L
L
K
N
Y
A
G
R
P
T
A
L
T
K
C
Q
N
I
T
A
G
T
R
--
T
T
L
Y
L
K
R
E
D
L
L
H
G
G
A
H
K
T
N
Q
V
L
G
Q
A
L
L
A
K
R
M
G
K
S
E
-
I
I
A
E
T
G
A
G
Q
H
G
V
A
S
A
L
A
S
A
L
L
G
L
K
C
R
I
Y
M
G
A
K
D
V
E
R
--
Q
S
P
N
V
F
R
M
R
L
M
G
A
E
V
I
P
-----
V
H
S
G
S
----------
A
T
L
K
D
A
C
N
E
A
L
R
D
W
S
G
S
Y
E
T
A
H
Y
M
L
G
T
A
A
G
P
H
P
Y
P
T
I
V
R
E
F
Q
R
M
I
G
E
E
T
K
A
Q
I
L
D
K
E
G
R
L
P
D
A
V
I
A
C
V
G
G
G
S
N
A
I
G
M
F
A
D
F
I
---
N
-
D
T--
S
V
G
L
I
G
V
E
----
P
G
G
H
G
I
E
T
G
E
H
--
G
A
P
L
K
H
----
G
R
V
G
I
Y
F
G
M
K
A
P
M
M
Q
T
A
D
G
Q
I
E
E
S
Y
S
I
S
A
G
L
D
F
P
S
V
G
P
Q
H
A
Y
L
N
S
I
G
R
A
D
Y
V
S
I
T
D
D
E
A
L
E
A
F
K
T
L
C
R
H
E
G
I
I
P
A
L
E
S
S
H
A
L
A
H
A
L
K
M
M
R
E
Q
P
E
K
---
E
Q
L
L
V
V
N
L
S
G
R
G
D
K
D
I
F
T
V
H
D
I
L
K
A
R
------
8
PsiBlast_PDB
89.16
50%
-71
- C3 -
1A5B
2
TRPB_SALTY
B:
[8-391]
-------------
Y
F
G
E
F
G
G
M
Y
V
P
Q
I
L
M
P
A
L
N
Q
L
E
E
A
F
V
R
A
Q
K
D
P
E
F
Q
A
Q
F
A
D
L
L
K
N
Y
A
G
R
P
T
A
L
T
K
C
Q
N
I
T
A
G
T
R
--
T
T
L
Y
L
K
R
E
D
L
L
H
G
G
A
H
K
T
N
Q
V
L
G
Q
A
L
L
A
K
R
M
G
K
S
E
-
I
I
A
E
T
G
A
G
Q
H
G
V
A
S
A
L
A
S
A
L
L
G
L
K
C
R
I
Y
M
G
A
K
D
V
E
R
--
Q
S
P
N
V
F
R
M
R
L
M
G
A
E
V
I
P
-----
V
H
S
G
S
----------
A
T
L
K
D
A
C
N
E
A
L
R
D
W
S
G
S
Y
E
T
A
H
Y
M
L
G
T
A
A
G
P
H
P
Y
P
T
I
V
R
E
F
Q
R
M
I
G
E
E
T
K
A
Q
I
L
D
K
E
G
R
L
P
D
A
V
I
A
C
V
G
G
G
S
N
A
I
G
M
F
A
D
F
I
---
N
-
D
T--
S
V
G
L
I
G
V
E
----
P
G
G
H
G
I
E
T
G
E
H
--
G
A
P
L
K
H
----
G
R
V
G
I
Y
F
G
M
K
A
P
M
M
Q
T
A
D
G
Q
I
E
E
S
Y
S
I
S
A
G
L
D
F
P
S
V
G
P
Q
H
A
Y
L
N
S
I
G
R
A
D
Y
V
S
I
T
D
D
E
A
L
E
A
F
K
T
L
C
R
H
E
G
I
I
P
A
L
E
S
S
H
A
L
A
H
A
L
K
M
M
R
E
Q
P
E
K
---
E
Q
L
L
V
V
N
L
S
G
R
G
D
K
D
I
F
T
V
H
D
I
L
---------
7
PsiBlast_PDB
89.14
50%
-70
- C3 -
1A5A
2
TRPB_SALTY
B:
[8-391]
-------------
Y
F
G
E
F
G
G
M
Y
V
P
Q
I
L
M
P
A
L
N
Q
L
E
E
A
F
V
R
A
Q
K
D
P
E
F
Q
A
Q
F
A
D
L
L
K
N
Y
A
G
R
P
T
A
L
T
K
C
Q
N
I
T
A
G
T
R
--
T
T
L
Y
L
K
R
E
D
L
L
H
G
G
A
H
K
T
N
Q
V
L
G
Q
A
L
L
A
K
R
M
G
K
S
E
-
I
I
A
E
T
G
A
G
Q
H
G
V
A
S
A
L
A
S
A
L
L
G
L
K
C
R
I
Y
M
G
A
K
D
V
E
R
--
Q
S
P
N
V
F
R
M
R
L
M
G
A
E
V
I
P
-----
V
H
S
G
S
----------
A
T
L
K
D
A
C
N
E
A
L
R
D
W
S
G
S
Y
E
T
A
H
Y
M
L
G
T
A
A
G
P
H
P
Y
P
T
I
V
R
E
F
Q
R
M
I
G
E
E
T
K
A
Q
I
L
D
K
E
G
R
L
P
D
A
V
I
A
C
V
G
G
G
S
N
A
I
G
M
F
A
D
F
I
---
N
-
D
T--
S
V
G
L
I
G
V
E
----
P
G
G
H
G
I
E
T
G
E
H
--
G
A
P
L
K
H
----
G
R
V
G
I
Y
F
G
M
K
A
P
M
M
Q
T
A
D
G
Q
I
E
E
S
Y
S
I
S
A
G
L
D
F
P
S
V
G
P
Q
H
A
Y
L
N
S
I
G
R
A
D
Y
V
S
I
T
D
D
E
A
L
E
A
F
K
T
L
C
R
H
E
G
I
I
P
A
L
E
S
S
H
A
L
A
H
A
L
K
M
M
R
E
Q
P
E
K
---
E
Q
L
L
V
V
N
L
S
G
R
G
D
K
D
I
F
T
V
H
D
I
L
---------
39
PsiBlast_CBE
89.06
50%
-67
- C3 -
1K8X
2
TRPB_SALTY
B:
[8-392]
-------------
Y
F
G
E
F
G
G
M
Y
V
P
Q
I
L
M
P
A
L
N
Q
L
E
E
A
F
V
S
A
Q
K
D
P
E
F
Q
A
Q
F
A
D
L
L
K
N
Y
A
G
R
P
T
A
L
T
K
C
Q
N
I
T
A
G
T
R
--
T
T
L
Y
L
K
R
E
D
L
L
H
G
G
A
H
K
T
N
Q
V
L
G
Q
A
L
L
A
K
R
M
G
K
S
E
-
I
I
A
E
T
G
A
G
Q
H
G
V
A
S
A
L
A
S
A
L
L
G
L
K
C
R
I
Y
M
G
A
K
D
V
E
R
--
Q
S
P
N
V
F
R
M
R
L
M
G
A
E
V
I
P
-----
V
H
S
G
S
----------
A
T
L
K
D
A
C
N
E
A
L
R
D
W
S
G
S
Y
E
T
A
H
Y
M
L
G
T
A
A
G
P
H
P
Y
P
T
I
V
R
E
F
Q
R
M
I
G
E
E
T
K
A
Q
I
L
D
K
E
G
R
L
P
D
A
V
I
A
C
V
G
G
G
S
N
A
I
G
M
F
A
D
F
I
---
N
-
D
T--
S
V
G
L
I
G
V
E
----
P
G
G
H
G
I
E
T
G
E
H
--
G
A
P
L
K
H
----
G
R
V
G
I
Y
F
G
M
K
A
P
M
M
Q
T
A
D
G
Q
I
E
E
S
Y
S
I
S
A
G
L
D
F
P
S
V
G
P
Q
H
A
Y
L
N
S
I
G
R
A
D
Y
V
S
I
T
D
D
E
A
L
E
A
F
K
T
L
C
R
H
E
G
I
I
P
A
L
E
S
S
H
A
L
A
H
A
L
K
M
M
R
E
Q
P
E
K
---
E
Q
L
L
V
V
N
L
S
G
R
G
D
K
D
I
F
T
V
H
D
I
L
K
--------
33
PsiBlast_CBE
89.03
50%
-62
- C3 -
4HPJ
11
TRPB_SALTY
B:
[8-395]
-------------
Y
F
G
E
F
G
G
M
Y
V
P
Q
I
L
M
P
A
L
N
Q
L
E
E
A
F
V
S
A
Q
K
D
P
E
F
Q
A
Q
F
A
D
L
L
K
N
Y
A
G
R
P
T
A
L
T
K
C
Q
N
I
T
A
G
T
R
--
T
T
L
Y
L
K
R
E
D
L
L
H
G
G
A
H
K
T
N
Q
V
L
G
Q
A
L
L
A
K
R
M
G
K
S
E
-
I
I
A
E
T
G
A
G
Q
H
G
V
A
S
A
L
A
S
A
L
L
G
L
K
C
R
I
Y
M
G
A
K
D
V
E
R
--
Q
S
P
N
V
F
R
M
R
L
M
G
A
E
V
I
P
-----
V
H
S
G
S
----------
A
T
L
K
D
A
C
N
E
A
L
R
D
W
S
G
S
Y
E
T
A
H
Y
M
L
G
T
A
A
G
P
H
P
Y
P
T
I
V
R
E
F
Q
R
M
I
G
E
E
T
K
A
Q
I
L
D
K
E
G
R
L
P
D
A
V
I
A
C
V
G
G
G
S
N
A
I
G
M
F
A
D
F
I
---
N
-
D
T--
S
V
G
L
I
G
V
E
----
P
G
G
H
G
I
E
T
G
E
H
--
G
A
P
L
K
H
----
G
R
V
G
I
Y
F
G
M
K
A
P
M
M
Q
T
A
D
G
Q
I
E
E
S
Y
S
I
S
A
G
L
D
F
P
S
V
G
P
Q
H
A
Y
L
N
S
I
G
R
A
D
Y
V
S
I
T
D
D
E
A
L
E
A
F
K
T
L
C
R
H
E
G
I
I
P
A
L
E
S
S
H
A
L
A
H
A
L
K
M
M
R
E
Q
P
E
K
---
E
Q
L
L
V
V
N
L
S
G
R
G
D
K
D
I
F
T
V
H
D
I
L
K
A
R
G
-----
56
PsiBlast_CBE
88.94
50%
-67
- C3 -
1A50
2
TRPB_SALTY
B:
[7-390]
-------------
Y
F
G
E
F
G
G
M
Y
V
P
Q
I
L
M
P
A
L
N
Q
L
E
E
A
F
V
R
A
Q
K
D
P
E
F
Q
A
Q
F
A
D
L
L
K
N
Y
A
G
R
P
T
A
L
T
K
C
Q
N
I
T
A
G
T
R
--
T
T
L
Y
L
K
R
E
D
L
L
H
G
G
A
H
K
T
N
Q
V
L
G
Q
A
L
L
A
K
R
M
G
K
S
E
-
I
I
A
E
T
G
A
G
Q
H
G
V
A
S
A
L
A
S
A
L
L
G
L
K
C
R
I
Y
M
G
A
K
D
V
E
R
--
Q
S
P
N
V
F
R
M
R
L
M
G
A
E
V
I
P
-----
V
H
S
G
S
----------
A
T
L
K
D
A
C
N
E
A
L
R
D
W
S
G
S
Y
E
T
A
H
Y
M
L
G
T
A
A
G
P
H
P
Y
P
T
I
V
R
E
F
Q
R
M
I
G
E
E
T
K
A
Q
I
L
D
K
E
G
R
L
P
D
A
V
I
A
C
V
G
G
G
S
N
A
I
G
M
F
A
D
F
I
---
N
-
D
T--
S
V
G
L
I
G
V
E
----
P
G
G
H
G
I
E
T
G
E
H
--
G
A
P
L
K
H
----
G
R
V
G
I
Y
F
G
M
K
A
P
M
M
Q
T
A
D
G
Q
I
E
E
S
Y
S
I
S
A
G
L
D
F
P
S
V
G
P
Q
H
A
Y
L
N
S
I
G
R
A
D
Y
V
S
I
T
D
D
E
A
L
E
A
F
K
T
L
C
R
H
E
G
I
I
P
A
L
E
S
S
H
A
L
A
H
A
L
K
M
M
R
E
Q
P
E
K
---
E
Q
L
L
V
V
N
L
S
G
R
G
D
K
D
I
F
T
V
H
D
I
L
---------
40
PsiBlast_CBE
88.89
50%
-70
- C3 -
1TTQ
2
TRPB_SALTY
B:
[8-391]
-------------
Y
F
G
E
F
G
G
M
Y
V
P
Q
I
L
M
P
A
L
N
Q
L
E
E
A
F
V
R
A
Q
K
D
P
E
F
Q
A
Q
F
A
D
L
L
K
N
Y
A
G
R
P
T
A
L
T
K
C
Q
N
I
T
A
G
T
R
--
T
T
L
Y
L
K
R
E
D
L
L
H
G
G
A
H
K
T
N
Q
V
L
G
Q
A
L
L
A
K
R
M
G
K
S
E
-
I
I
A
E
T
G
A
G
Q
H
G
V
A
S
A
L
A
S
A
L
L
G
L
K
C
R
I
Y
M
G
A
K
D
V
E
R
--
Q
S
P
N
V
F
R
M
R
L
M
G
A
E
V
I
P
-----
V
H
S
G
S
----------
A
T
L
K
D
A
C
N
E
A
L
R
D
W
S
G
S
Y
E
T
A
H
Y
M
L
G
T
A
A
G
P
H
P
Y
P
T
I
V
R
E
F
Q
R
M
I
G
E
E
T
K
A
Q
I
L
D
K
E
G
R
L
P
D
A
V
I
A
C
V
G
G
G
S
N
A
I
G
M
F
A
D
F
I
---
N
-
D
T--
S
V
G
L
I
G
V
E
----
P
G
G
H
G
I
E
T
G
E
H
--
G
A
P
L
K
H
----
G
R
V
G
I
Y
F
G
M
K
A
P
M
M
Q
T
A
D
G
Q
I
E
E
S
Y
S
I
S
A
G
L
D
F
P
S
V
G
P
Q
H
A
Y
L
N
S
I
G
R
A
D
Y
V
S
I
T
D
D
E
A
L
E
A
F
K
T
L
C
R
H
E
G
I
I
P
A
L
E
S
S
H
A
L
A
H
A
L
K
M
M
R
E
Q
P
E
K
---
E
Q
L
L
V
V
N
L
S
G
R
G
D
K
D
I
F
T
V
H
D
I
L
---------
9
PsiBlast_PDB
88.84
50%
-67
- C3 -
1BEU
2
TRPB_SALTY
B:
[8-391]
-------------
Y
F
G
E
F
G
G
M
Y
V
P
Q
I
L
M
P
A
L
N
Q
L
E
E
A
F
V
R
A
Q
K
D
P
E
F
Q
A
Q
F
A
D
L
L
K
N
Y
A
G
R
P
T
A
L
T
K
C
Q
N
I
T
A
G
T
R
--
T
T
L
Y
L
K
R
E
D
L
L
H
G
G
A
H
K
T
N
Q
V
L
G
Q
A
L
L
A
K
R
M
G
K
S
E
-
I
I
A
E
T
G
A
G
Q
H
G
V
A
S
A
L
A
S
A
L
L
G
L
K
C
R
I
Y
M
G
A
K
D
V
E
R
--
Q
S
P
N
V
F
R
M
R
L
M
G
A
E
V
I
P
-----
V
H
S
G
S
----------
A
T
L
K
D
A
C
N
E
A
L
R
D
W
S
G
S
Y
E
T
A
H
Y
M
L
G
T
A
A
G
P
H
P
Y
P
T
I
V
R
E
F
Q
R
M
I
G
E
E
T
K
A
Q
I
L
D
K
E
G
R
L
P
D
A
V
I
A
C
V
G
G
G
S
N
A
I
G
M
F
A
D
F
I
---
N
-
D
T--
S
V
G
L
I
G
V
E
----
P
G
G
H
G
I
E
T
G
E
H
--
G
A
P
L
K
H
----
G
R
V
G
I
Y
F
G
M
K
A
P
M
M
Q
T
A
D
G
Q
I
E
E
S
Y
S
I
S
A
G
L
D
F
P
S
V
G
P
Q
H
A
Y
L
N
S
I
G
R
A
D
Y
V
S
I
T
D
D
E
A
L
E
A
F
K
T
L
C
R
H
E
G
I
I
P
A
L
E
S
S
H
A
L
A
H
A
L
K
M
M
R
E
Q
P
E
K
---
E
Q
L
L
V
V
N
L
S
G
R
G
D
K
D
I
F
T
V
H
D
I
L
---------
30
PsiBlast_CBE
88.57
50%
-62
- C3 -
4KKX
15
TRPB_SALTY
B:
[8-395]
-------------
Y
F
G
E
F
G
G
M
Y
V
P
Q
I
L
M
P
A
L
N
Q
L
E
E
A
F
V
S
A
Q
K
D
P
E
F
Q
A
Q
F
A
D
L
L
K
N
Y
A
G
R
P
T
A
L
T
K
C
Q
N
I
T
A
G
T
R
--
T
T
L
Y
L
K
R
E
D
L
L
H
G
G
A
H
K
T
N
Q
V
L
G
Q
A
L
L
A
K
R
M
G
K
S
E
-
I
I
A
E
T
G
A
G
Q
H
G
V
A
S
A
L
A
S
A
L
L
G
L
K
C
R
I
Y
M
G
A
K
D
V
E
R
--
Q
S
P
N
V
F
R
M
R
L
M
G
A
E
V
I
P
-----
V
H
S
G
S
----------
A
T
L
K
D
A
C
N
E
A
L
R
D
W
S
G
S
Y
E
T
A
H
Y
M
L
G
T
A
A
G
P
H
P
Y
P
T
I
V
R
E
F
Q
R
M
I
G
E
E
T
K
A
Q
I
L
D
K
E
G
R
L
P
D
A
V
I
A
C
V
G
G
G
S
N
A
I
G
M
F
A
D
F
I
---
N
-
D
T--
S
V
G
L
I
G
V
E
----
P
G
G
H
G
I
E
T
G
E
H
--
G
A
P
L
K
H
----
G
R
V
G
I
Y
F
G
M
K
A
P
M
M
Q
T
A
D
G
Q
I
E
E
S
Y
S
I
S
A
G
L
D
F
P
S
V
G
P
Q
H
A
Y
L
N
S
I
G
R
A
D
Y
V
S
I
T
D
D
E
A
L
E
A
F
K
T
L
C
R
H
E
G
I
I
P
A
L
E
S
S
H
A
L
A
H
A
L
K
M
M
R
E
Q
P
E
K
---
E
Q
L
L
V
V
N
L
S
G
R
G
D
K
D
I
F
T
V
H
D
I
L
K
A
R
G
-----
59
PsiBlast_CBE
88.53
50%
-68
- C3 -
1K7X
2
TRPB_SALTY
B:
[7-390]
-------------
Y
F
G
E
F
G
G
M
Y
V
P
Q
I
L
M
P
A
L
N
Q
L
E
E
A
F
V
S
A
Q
K
D
P
E
F
Q
A
Q
F
A
D
L
L
K
N
Y
A
G
R
P
T
A
L
T
K
C
Q
N
I
T
A
G
T
R
--
T
T
L
Y
L
K
R
E
D
L
L
H
G
G
A
H
K
T
N
Q
V
L
G
Q
A
L
L
A
K
R
M
G
K
S
E
-
I
I
A
E
T
G
A
G
Q
H
G
V
A
S
A
L
A
S
A
L
L
G
L
K
C
R
I
Y
M
G
A
K
D
V
E
R
--
Q
S
P
N
V
F
R
M
R
L
M
G
A
E
V
I
P
-----
V
H
S
G
S
----------
A
T
L
K
D
A
C
N
E
A
L
R
D
W
P
G
S
Y
E
T
A
H
Y
M
L
G
T
A
A
G
P
H
P
Y
P
T
I
V
R
E
F
Q
R
M
I
G
E
E
T
K
A
Q
I
L
D
K
E
G
R
L
P
D
A
V
I
A
C
V
G
G
G
S
N
A
I
G
M
F
A
D
F
I
---
N
-
D
T--
S
V
G
L
I
G
V
E
----
P
G
G
H
G
I
E
T
G
E
H
--
G
A
P
L
K
H
----
G
R
V
G
I
Y
F
G
M
K
A
P
M
M
Q
T
A
D
G
Q
I
E
E
S
Y
S
I
S
A
G
L
D
F
P
S
V
G
P
Q
H
A
Y
L
N
S
I
G
R
A
D
Y
V
S
I
T
D
D
E
A
L
E
A
F
K
T
L
C
R
H
E
G
I
I
P
A
L
E
S
S
H
A
L
A
H
A
L
K
M
M
R
E
Q
P
E
K
---
E
Q
L
L
V
V
N
L
S
G
R
G
D
K
D
I
F
T
V
H
D
I
L
---------
62
PsiBlast_CBE
88.50
50%
-68
- C3 -
1UBS
3
TRPB_SALTY
B:
[8-391]
-------------
Y
F
G
E
F
G
G
M
Y
V
P
Q
I
L
M
P
A
L
N
Q
L
E
E
A
F
V
R
A
Q
K
D
P
E
F
Q
A
Q
F
A
D
L
L
K
N
Y
A
G
R
P
T
A
L
T
K
C
Q
N
I
T
A
G
T
R
--
T
T
L
Y
L
K
R
E
D
L
L
H
G
G
A
H
T
T
N
Q
V
L
G
Q
A
L
L
A
K
R
M
G
K
S
E
-
I
I
A
E
T
G
A
G
Q
H
G
V
A
S
A
L
A
S
A
L
L
G
L
K
C
R
I
Y
M
G
A
K
D
V
E
R
--
Q
S
P
N
V
F
R
M
R
L
M
G
A
E
V
I
P
-----
V
H
S
G
S
----------
A
T
L
K
D
A
C
N
E
A
L
R
D
W
S
G
S
Y
E
T
A
H
Y
M
L
G
T
A
A
G
P
H
P
Y
P
T
I
V
R
E
F
Q
R
M
I
G
E
E
T
K
A
Q
I
L
D
K
E
G
R
L
P
D
A
V
I
A
C
V
G
G
G
S
N
A
I
G
M
F
A
D
F
I
---
N
-
D
T--
S
V
G
L
I
G
V
E
----
P
G
G
H
G
I
E
T
G
E
H
--
G
A
P
L
K
H
----
G
R
V
G
I
Y
F
G
M
K
A
P
M
M
Q
T
A
D
G
Q
I
E
E
S
Y
S
I
S
A
G
L
D
F
P
S
V
G
P
Q
H
A
Y
L
N
S
I
G
R
A
D
Y
V
S
I
T
D
D
E
A
L
E
A
F
K
T
L
C
R
H
E
G
I
I
P
A
L
E
S
S
H
A
L
A
H
A
L
K
M
M
R
E
Q
P
E
K
---
E
Q
L
L
V
V
N
L
S
G
R
G
D
K
D
I
F
T
V
H
D
I
L
---------
48
PsiBlast_CBE
88.48
50%
-68
- C3 -
1BKS
2
TRPB_SALTY
B:
[8-394]
-------------
Y
F
G
E
F
G
G
M
Y
V
P
Q
I
L
M
P
A
L
N
Q
L
E
E
A
F
V
R
A
Q
K
D
P
E
F
Q
A
Q
F
A
D
L
L
K
N
Y
A
G
R
P
T
A
L
T
K
C
Q
N
I
T
A
G
T
R
--
T
T
L
Y
L
K
R
E
D
L
L
H
G
G
A
H
K
T
N
Q
V
L
G
Q
A
L
L
A
K
R
M
G
K
S
E
-
I
I
A
E
T
G
A
G
Q
H
G
V
A
S
A
L
A
S
A
L
L
G
L
K
C
R
I
Y
M
G
A
K
D
V
E
R
--
Q
S
P
N
V
F
R
M
R
L
M
G
A
E
V
I
P
-----
V
H
S
G
S
----------
A
T
L
K
D
A
C
N
E
A
L
R
D
W
S
G
S
Y
E
T
A
H
Y
M
L
G
T
A
A
G
P
H
P
Y
P
T
I
V
R
E
F
Q
R
M
I
G
E
E
T
K
A
Q
I
L
D
K
E
G
R
L
P
D
A
V
I
A
C
V
G
G
G
S
N
A
I
G
M
F
A
D
F
I
---
N
-
D
T--
S
V
G
L
I
G
V
E
----
P
G
G
H
G
I
E
T
G
E
H
--
G
A
P
L
K
H
----
G
R
V
G
I
Y
F
G
M
K
A
P
M
M
Q
T
A
D
G
Q
I
E
E
S
Y
S
I
S
A
G
L
D
F
P
S
V
G
P
Q
H
A
Y
L
N
S
I
G
R
A
D
Y
V
S
I
T
D
D
E
A
L
E
A
F
K
T
L
C
R
H
E
G
I
I
P
A
L
E
S
S
H
A
L
A
H
A
L
K
M
M
R
E
Q
P
E
K
---
E
Q
L
L
V
V
N
L
S
G
R
G
D
K
D
I
F
T
V
H
D
I
L
K
A
R
------
13
PsiBlast_PDB
88.38
50%
-74
- C3 -
1K7F
1
TRPB_SALTY
B:
[7-394]
-------------
Y
F
G
E
F
G
G
M
Y
V
P
Q
I
L
M
P
A
L
N
Q
L
E
E
A
F
V
S
A
Q
K
D
P
E
F
Q
A
Q
F
A
D
L
L
K
N
Y
A
G
R
P
T
A
L
T
K
C
Q
N
I
T
A
G
T
R
--
T
T
L
Y
L
K
R
E
D
L
L
H
G
G
A
H
K
T
N
Q
V
L
G
Q
A
L
L
A
K
R
M
G
K
S
E
-
I
I
A
E
T
G
A
G
Q
H
G
V
A
S
A
L
A
S
A
L
L
G
L
K
C
R
I
Y
M
G
A
K
D
V
E
R
--
Q
S
P
N
V
F
R
M
R
L
M
G
A
E
V
I
P
-----
V
H
S
G
S
----------
A
T
L
K
D
A
C
N
E
A
L
R
D
W
S
G
S
Y
E
T
A
H
Y
M
L
G
T
A
A
G
P
H
P
Y
P
T
I
V
R
E
F
Q
R
M
I
G
E
E
T
K
A
Q
I
L
D
K
E
G
R
L
P
D
A
V
I
A
C
V
G
G
G
S
N
A
I
G
M
F
A
D
F
I
---
N
-
D
T--
S
V
G
L
I
G
V
E
----
P
G
G
H
--------------------
R
V
G
I
Y
F
G
M
K
A
P
M
M
Q
T
A
D
G
Q
I
E
E
S
Y
S
I
S
A
G
L
D
F
P
S
V
G
P
Q
H
A
Y
L
N
S
I
G
R
A
D
Y
V
S
I
T
D
D
E
A
L
E
A
F
K
T
L
C
R
H
E
G
I
I
P
A
L
E
S
S
H
A
L
A
H
A
L
K
M
M
R
E
Q
P
E
K
---
E
Q
L
L
V
V
N
L
S
G
R
G
D
K
D
I
F
T
V
H
D
I
L
K
A
R
G
-----
20
PsiBlast_PDB
88.26
50%
-63
- C3 -
2J9X
7
TRPB_SALTY
B:
[7-394]
-------------
Y
F
G
E
F
G
G
M
Y
V
P
Q
I
L
M
P
A
L
N
Q
L
E
E
A
F
V
S
A
Q
K
D
P
E
F
Q
A
Q
F
A
D
L
L
K
N
Y
A
G
R
P
T
A
L
T
K
C
Q
N
I
T
A
G
T
R
--
T
T
L
Y
L
K
R
E
D
L
L
H
G
G
A
H
K
T
N
Q
V
L
G
Q
A
L
L
A
K
R
M
G
K
S
E
-
I
I
A
E
T
G
A
G
Q
H
G
V
A
S
A
L
A
S
A
L
L
G
L
K
C
R
I
Y
M
G
A
K
D
V
E
R
--
Q
S
P
N
V
F
R
M
R
L
M
G
A
E
V
I
P
-----
V
H
S
G
S
----------
A
T
L
K
D
A
C
N
E
A
L
R
D
W
S
G
S
Y
E
T
A
H
Y
M
L
G
T
A
A
G
P
H
P
Y
P
T
I
V
R
E
F
Q
R
M
I
G
E
E
T
K
A
Q
I
L
D
K
E
G
R
L
P
D
A
V
I
A
C
V
G
G
G
S
N
A
I
G
M
F
A
D
F
I
---
N
-
D
T--
S
V
G
L
I
G
V
E
----
P
G
G
H
G
I
E
T
G
E
H
--
G
A
P
L
K
H
----
G
R
V
G
I
Y
F
G
M
K
A
P
M
M
Q
T
A
D
G
Q
I
E
E
S
Y
S
I
S
A
G
L
D
F
P
S
V
G
P
Q
H
A
Y
L
N
S
I
G
R
A
D
Y
V
S
I
T
D
D
E
A
L
E
A
F
K
T
L
C
R
H
E
G
I
I
P
A
L
E
S
S
H
A
L
A
H
A
L
K
M
M
R
E
Q
P
E
K
---
E
Q
L
L
V
V
N
L
S
G
R
G
D
K
D
I
F
T
V
H
D
I
L
K
A
R
G
-----
66
PsiBlast_CBE
88.17
50%
-62
- C3 -
2TYS
2
TRPB_SALTY
B:
[8-395]
-------------
Y
F
G
E
F
G
G
M
Y
V
P
Q
I
L
M
P
A
L
N
Q
L
E
E
A
F
V
R
A
Q
K
D
P
E
F
Q
A
Q
F
A
D
L
L
K
N
Y
A
G
R
P
T
A
L
T
K
C
Q
N
I
T
A
G
T
R
--
T
T
L
Y
L
K
R
E
D
L
L
H
G
G
A
H
T
T
N
Q
V
L
G
Q
A
L
L
A
K
R
M
G
K
S
E
-
I
I
A
E
T
G
A
G
Q
H
G
V
A
S
A
L
A
S
A
L
L
G
L
K
C
R
I
Y
M
G
A
K
D
V
E
R
--
Q
S
P
N
V
F
R
M
R
L
M
G
A
E
V
I
P
-----
V
H
S
G
S
----------
A
T
L
K
D
A
C
N
E
A
L
R
D
W
S
G
S
Y
E
T
A
H
Y
M
L
G
T
A
A
G
P
H
P
Y
P
T
I
V
R
E
F
Q
R
M
I
G
E
E
T
K
A
Q
I
L
D
K
E
G
R
L
P
D
A
V
I
A
C
V
G
G
G
S
N
A
I
G
M
F
A
D
F
I
---
N
-
D
T--
S
V
G
L
I
G
V
E
----
P
G
G
H
G
I
E
T
G
E
H
--
G
A
P
L
K
H
----
G
R
V
G
I
Y
F
G
M
K
A
P
M
M
Q
T
A
D
G
Q
I
E
E
S
Y
S
I
S
A
G
L
D
F
P
S
V
G
P
Q
H
A
Y
L
N
S
I
G
R
A
D
Y
V
S
I
T
D
D
E
A
L
E
A
F
K
T
L
C
R
H
E
G
I
I
P
A
L
E
S
S
H
A
L
A
H
A
L
K
M
M
R
E
Q
P
E
K
---
E
Q
L
L
V
V
N
L
S
G
R
G
D
K
D
I
F
T
V
H
D
I
L
K
A
R
G
-----
41
PsiBlast_CBE
88.15
50%
-70
- C3 -
1TTP
3
TRPB_SALTY
B:
[8-391]
-------------
Y
F
G
E
F
G
G
M
Y
V
P
Q
I
L
M
P
A
L
N
Q
L
E
E
A
F
V
R
A
Q
K
D
P
E
F
Q
A
Q
F
A
D
L
L
K
N
Y
A
G
R
P
T
A
L
T
K
C
Q
N
I
T
A
G
T
R
--
T
T
L
Y
L
K
R
E
D
L
L
H
G
G
A
H
K
T
N
Q
V
L
G
Q
A
L
L
A
K
R
M
G
K
S
E
-
I
I
A
E
T
G
A
G
Q
H
G
V
A
S
A
L
A
S
A
L
L
G
L
K
C
R
I
Y
M
G
A
K
D
V
E
R
--
Q
S
P
N
V
F
R
M
R
L
M
G
A
E
V
I
P
-----
V
H
S
G
S
----------
A
T
L
K
D
A
C
N
E
A
L
R
D
W
S
G
S
Y
E
T
A
H
Y
M
L
G
T
A
A
G
P
H
P
Y
P
T
I
V
R
E
F
Q
R
M
I
G
E
E
T
K
A
Q
I
L
D
K
E
G
R
L
P
D
A
V
I
A
C
V
G
G
G
S
N
A
I
G
M
F
A
D
F
I
---
N
-
D
T--
S
V
G
L
I
G
V
E
----
P
G
G
H
G
I
E
T
G
E
H
--
G
A
P
L
K
H
----
G
R
V
G
I
Y
F
G
M
K
A
P
M
M
Q
T
A
D
G
Q
I
E
E
S
Y
S
I
S
A
G
L
D
F
P
S
V
G
P
Q
H
A
Y
L
N
S
I
G
R
A
D
Y
V
S
I
T
D
D
E
A
L
E
A
F
K
T
L
C
R
H
E
G
I
I
P
A
L
E
S
S
H
A
L
A
H
A
L
K
M
M
R
E
Q
P
E
K
---
E
Q
L
L
V
V
N
L
S
G
R
G
D
K
D
I
F
T
V
H
D
I
L
---------
43
PsiBlast_CBE
88.06
50%
-67
- C3 -
1CX9
2
TRPB_SALTY
B:
[8-389]
-------------
Y
F
G
E
F
G
G
M
Y
V
P
Q
I
L
M
P
A
L
N
Q
L
E
E
A
F
V
R
A
Q
K
D
P
E
F
Q
A
Q
F
A
D
L
L
K
N
Y
A
G
R
P
T
A
L
T
K
C
Q
N
I
T
A
G
T
R
--
T
T
L
Y
L
K
R
E
D
L
L
H
G
G
A
H
K
T
N
Q
V
L
G
Q
A
L
L
A
K
R
M
G
K
S
E
-
I
I
A
E
T
G
A
G
Q
H
G
V
A
S
A
L
A
S
A
L
L
G
L
K
C
R
I
Y
M
G
A
K
D
V
E
R
--
Q
S
P
N
V
F
R
M
R
L
M
G
A
E
V
I
P
-----
V
H
S
G
S
----------
A
T
L
K
D
A
C
N
E
A
L
R
D
W
S
G
S
Y
E
T
A
H
Y
M
L
G
T
A
A
G
P
H
P
Y
P
T
I
V
R
E
F
Q
R
M
I
G
E
E
T
K
A
Q
I
L
D
K
E
G
R
L
P
D
A
V
I
A
C
V
G
G
G
S
N
A
I
G
M
F
A
D
F
I
---
N
-
D
T--
S
V
G
L
I
G
V
E
----
P
G
G
H
G
I
E
T
G
E
H
--
G
A
P
L
K
H
----
G
R
V
G
I
Y
F
G
M
K
A
P
M
M
Q
T
A
D
G
Q
I
E
E
S
Y
S
I
S
A
G
L
D
F
P
S
V
G
P
Q
H
A
Y
L
N
S
I
G
R
A
D
Y
V
S
I
T
D
D
E
A
L
E
A
F
K
T
L
C
R
H
E
G
I
I
P
A
L
E
S
S
H
A
L
A
H
A
L
K
M
M
R
E
Q
P
E
K
---
E
Q
L
L
V
V
N
L
S
G
R
G
D
K
D
I
F
T
V
H
D
-----------
58
PsiBlast_CBE
88.05
50%
-66
- C3 -
1K8Y
2
TRPB_SALTY
B:
[7-390]
-------------
Y
F
G
E
F
G
G
M
Y
V
P
Q
I
L
M
P
A
L
N
Q
L
E
E
A
F
V
S
A
Q
K
D
P
E
F
Q
A
Q
F
A
D
L
L
K
N
Y
A
G
R
P
T
A
L
T
K
C
Q
N
I
T
A
G
T
R
--
T
T
L
Y
L
K
R
E
D
L
L
H
G
G
A
H
K
T
N
Q
V
L
G
Q
A
L
L
A
K
R
M
G
K
S
E
-
I
I
A
E
T
G
A
G
Q
H
G
V
A
S
A
L
A
S
A
L
L
G
L
K
C
R
I
Y
M
G
A
K
D
V
E
R
--
Q
S
P
N
V
F
R
M
R
L
M
G
A
E
V
I
P
-----
V
H
S
G
S
----------
A
T
L
K
D
A
C
N
E
A
L
R
D
W
P
G
S
Y
E
T
A
H
Y
M
L
G
T
A
A
G
P
H
P
Y
P
T
I
V
R
E
F
Q
R
M
I
G
E
E
T
K
A
Q
I
L
D
K
E
G
R
L
P
D
A
V
I
A
C
V
G
G
G
S
N
A
I
G
M
F
A
D
F
I
---
N
-
D
T--
S
V
G
L
I
G
V
E
----
P
G
G
H
G
I
E
T
G
E
H
--
G
A
P
L
K
H
----
G
R
V
G
I
Y
F
G
M
K
A
P
M
M
Q
T
A
D
G
Q
I
E
E
S
Y
S
I
S
A
G
L
D
F
P
S
V
G
P
Q
H
A
Y
L
N
S
I
G
R
A
D
Y
V
S
I
T
D
D
E
A
L
E
A
F
K
T
L
C
R
H
E
G
I
I
P
A
L
E
S
S
H
A
L
A
H
A
L
K
M
M
R
E
Q
P
E
K
---
E
Q
L
L
V
V
N
L
S
G
R
G
D
K
D
I
F
T
V
H
D
I
L
---------
45
PsiBlast_CBE
87.92
50%
-65
- C3 -
1C9D
2
TRPB_SALTY
B:
[8-389]
-------------
Y
F
G
E
F
G
G
M
Y
V
P
Q
I
L
M
P
A
L
N
Q
L
E
E
A
F
V
R
A
Q
K
D
P
E
F
Q
A
Q
F
A
D
L
L
K
N
Y
A
G
R
P
T
A
L
T
K
C
Q
N
I
T
A
G
T
R
--
T
T
L
Y
L
K
R
E
D
L
L
H
G
G
A
H
K
T
N
Q
V
L
G
Q
A
L
L
A
K
R
M
G
K
S
E
-
I
I
A
E
T
G
A
G
Q
H
G
V
A
S
A
L
A
S
A
L
L
G
L
K
C
R
I
Y
M
G
A
K
D
V
E
R
--
Q
S
P
N
V
F
R
M
R
L
M
G
A
E
V
I
P
-----
V
H
S
G
S
----------
A
T
L
K
D
A
C
N
E
A
L
R
D
W
S
G
S
Y
E
T
A
H
Y
M
L
G
T
A
A
G
P
H
P
Y
P
T
I
V
R
E
F
Q
R
M
I
G
E
E
T
K
A
Q
I
L
D
K
E
G
R
L
P
D
A
V
I
A
C
V
G
G
G
S
N
A
I
G
M
F
A
D
F
I
---
N
-
D
T--
S
V
G
L
I
G
V
E
----
P
G
G
H
G
I
E
T
G
E
H
--
G
A
P
L
K
H
----
G
R
V
G
I
Y
F
G
M
K
A
P
M
M
Q
T
A
D
G
Q
I
E
E
S
Y
S
I
S
A
G
L
D
F
P
S
V
G
P
Q
H
A
Y
L
N
S
I
G
R
A
D
Y
V
S
I
T
D
D
E
A
L
E
A
F
K
T
L
C
R
H
E
G
I
I
P
A
L
E
S
S
H
A
L
A
H
A
L
K
M
M
R
E
Q
P
E
K
---
E
Q
L
L
V
V
N
L
S
G
R
G
D
K
D
I
F
T
V
H
D
-----------
49
PsiBlast_CBE
87.89
50%
-64
- C3 -
1A5S
3
TRPB_SALTY
B:
[8-389]
-------------
Y
F
G
E
F
G
G
M
Y
V
P
Q
I
L
M
P
A
L
N
Q
L
E
E
A
F
V
R
A
Q
K
D
P
E
F
Q
A
Q
F
A
D
L
L
K
N
Y
A
G
R
P
T
A
L
T
K
C
Q
N
I
T
A
G
T
R
--
T
T
L
Y
L
K
R
E
D
L
L
H
G
G
A
H
K
T
N
Q
V
L
G
Q
A
L
L
A
K
R
M
G
K
S
E
-
I
I
A
E
T
G
A
G
Q
H
G
V
A
S
A
L
A
S
A
L
L
G
L
K
C
R
I
Y
M
G
A
K
D
V
E
R
--
Q
S
P
N
V
F
R
M
R
L
M
G
A
E
V
I
P
-----
V
H
S
G
S
----------
A
T
L
K
D
A
C
N
E
A
L
R
D
W
S
G
S
Y
E
T
A
H
Y
M
L
G
T
A
A
G
P
H
P
Y
P
T
I
V
R
E
F
Q
R
M
I
G
E
E
T
K
A
Q
I
L
D
K
E
G
R
L
P
D
A
V
I
A
C
V
G
G
G
S
N
A
I
G
M
F
A
D
F
I
---
N
-
D
T--
S
V
G
L
I
G
V
E
----
P
G
G
H
G
I
E
T
G
E
H
--
G
A
P
L
K
H
----
G
R
V
G
I
Y
F
G
M
K
A
P
M
M
Q
T
A
D
G
Q
I
E
E
S
Y
S
I
S
A
G
L
D
F
P
S
V
G
P
Q
H
A
Y
L
N
S
I
G
R
A
D
Y
V
S
I
T
D
D
E
A
L
E
A
F
K
T
L
C
R
H
E
G
I
I
P
A
L
E
S
S
H
A
L
A
H
A
L
K
M
M
R
E
Q
P
E
K
---
E
Q
L
L
V
V
N
L
S
G
R
G
D
K
D
I
F
T
V
H
D
-----------
61
PsiBlast_CBE
87.69
50%
-65
- C3 -
2TRS
2
TRPB_SALTY
B:
[8-391]
-------------
Y
F
G
E
F
G
G
M
Y
V
P
Q
I
L
M
P
A
L
N
Q
L
E
E
A
F
V
R
A
Q
K
D
P
E
F
Q
A
Q
F
A
D
L
L
K
N
Y
A
G
R
P
T
A
L
T
K
C
Q
N
I
T
A
G
T
R
--
T
T
L
Y
L
K
R
E
D
L
L
H
G
G
A
H
T
T
N
Q
V
L
G
Q
A
L
L
A
K
R
M
G
K
S
E
-
I
I
A
E
T
G
A
G
Q
H
G
V
A
S
A
L
A
S
A
L
L
G
L
K
C
R
I
Y
M
G
A
K
D
V
E
R
--
Q
S
P
N
V
F
R
M
R
L
M
G
A
E
V
I
P
-----
V
H
S
G
S
----------
A
T
L
K
D
A
C
N
E
A
L
R
D
W
S
G
S
Y
E
T
A
H
Y
M
L
G
T
A
A
G
P
H
P
Y
P
T
I
V
R
E
F
Q
R
M
I
G
E
E
T
K
A
Q
I
L
D
K
E
G
R
L
P
D
A
V
I
A
C
V
G
G
G
S
N
A
I
G
M
F
A
D
F
I
---
N
-
D
T--
S
V
G
L
I
G
V
E
----
P
G
G
H
G
I
E
T
G
E
H
--
G
A
P
L
K
H
----
G
R
V
G
I
Y
F
G
M
K
A
P
M
M
Q
T
A
D
G
Q
I
E
E
S
Y
S
I
S
A
G
L
D
F
P
S
V
G
P
Q
H
A
Y
L
N
S
I
G
R
A
D
Y
V
S
I
T
D
D
E
A
L
E
A
F
K
T
L
C
R
H
E
G
I
I
P
A
L
E
S
S
H
A
L
A
H
A
L
K
M
M
R
E
Q
P
E
K
---
E
Q
L
L
V
V
N
L
S
G
R
G
D
K
D
I
F
T
V
H
D
I
L
---------
29
PsiBlast_CBE
87.68
50%
-62
- C3 -
3CEP
4
TRPB_SALTY
B:
[7-393]
-------------
Y
F
G
E
F
G
G
M
Y
V
P
Q
I
L
M
P
A
L
N
Q
L
E
E
A
F
V
S
A
Q
K
D
P
E
F
Q
A
Q
F
A
D
L
L
K
N
Y
A
G
R
P
T
A
L
T
K
C
Q
N
I
T
A
G
T
R
--
T
T
L
Y
L
K
R
E
D
L
L
H
G
G
A
H
K
T
N
Q
V
L
G
Q
A
L
L
A
K
R
M
G
K
S
E
-
I
I
A
E
T
G
A
G
Q
H
G
V
A
S
A
L
A
S
A
L
L
G
L
K
C
R
I
Y
M
G
A
K
D
V
E
R
--
Q
S
P
N
V
F
R
M
R
L
M
G
A
E
V
I
P
-----
V
H
S
G
S
----------
A
T
L
K
D
A
C
N
E
A
L
R
D
W
S
G
S
Y
E
T
A
H
Y
M
L
G
T
A
A
G
P
H
P
Y
P
T
I
V
R
E
F
Q
R
M
I
G
E
E
T
K
A
Q
I
L
D
K
E
G
R
L
P
D
A
V
I
A
C
V
G
G
G
S
N
A
I
G
M
F
A
D
F
I
---
N
-
D
T--
S
V
G
L
I
G
V
E
----
P
G
G
H
G
I
E
T
G
E
H
--
G
A
P
L
K
H
----
G
R
V
G
I
Y
F
G
M
K
A
P
M
M
Q
T
A
D
G
Q
I
E
E
S
Y
S
I
S
A
G
L
D
F
P
S
V
G
P
Q
H
A
Y
L
N
S
I
G
R
A
D
Y
V
S
I
T
D
D
E
A
L
E
A
F
K
T
L
C
R
H
E
G
I
I
P
A
L
E
S
S
H
A
L
A
H
A
L
K
M
M
R
E
Q
P
E
K
---
E
Q
L
L
V
V
N
L
S
G
R
G
D
K
D
I
F
T
V
H
D
I
L
K
A
R
------
47
PsiBlast_CBE
87.49
50%
-64
- C3 -
1C29
2
TRPB_SALTY
B:
[8-389]
-------------
Y
F
G
E
F
G
G
M
Y
V
P
Q
I
L
M
P
A
L
N
Q
L
E
E
A
F
V
R
A
Q
K
D
P
E
F
Q
A
Q
F
A
D
L
L
K
N
Y
A
G
R
P
T
A
L
T
K
C
Q
N
I
T
A
G
T
R
--
T
T
L
Y
L
K
R
E
D
L
L
H
G
G
A
H
K
T
N
Q
V
L
G
Q
A
L
L
A
K
R
M
G
K
S
E
-
I
I
A
E
T
G
A
G
Q
H
G
V
A
S
A
L
A
S
A
L
L
G
L
K
C
R
I
Y
M
G
A
K
D
V
E
R
--
Q
S
P
N
V
F
R
M
R
L
M
G
A
E
V
I
P
-----
V
H
S
G
S
----------
A
T
L
K
D
A
C
N
E
A
L
R
D
W
S
G
S
Y
E
T
A
H
Y
M
L
G
T
A
A
G
P
H
P
Y
P
T
I
V
R
E
F
Q
R
M
I
G
E
E
T
K
A
Q
I
L
D
K
E
G
R
L
P
D
A
V
I
A
C
V
G
G
G
S
N
A
I
G
M
F
A
D
F
I
---
N
-
D
T--
S
V
G
L
I
G
V
E
----
P
G
G
H
G
I
E
T
G
E
H
--
G
A
P
L
K
H
----
G
R
V
G
I
Y
F
G
M
K
A
P
M
M
Q
T
A
D
G
Q
I
E
E
S
Y
S
I
S
A
G
L
D
F
P
S
V
G
P
Q
H
A
Y
L
N
S
I
G
R
A
D
Y
V
S
I
T
D
D
E
A
L
E
A
F
K
T
L
C
R
H
E
G
I
I
P
A
L
E
S
S
H
A
L
A
H
A
L
K
M
M
R
E
Q
P
E
K
---
E
Q
L
L
V
V
N
L
S
G
R
G
D
K
D
I
F
T
V
H
D
-----------
46
PsiBlast_CBE
87.38
50%
-66
- C3 -
1C8V
2
TRPB_SALTY
B:
[8-389]
-------------
Y
F
G
E
F
G
G
M
Y
V
P
Q
I
L
M
P
A
L
N
Q
L
E
E
A
F
V
R
A
Q
K
D
P
E
F
Q
A
Q
F
A
D
L
L
K
N
Y
A
G
R
P
T
A
L
T
K
C
Q
N
I
T
A
G
T
R
--
T
T
L
Y
L
K
R
E
D
L
L
H
G
G
A
H
K
T
N
Q
V
L
G
Q
A
L
L
A
K
R
M
G
K
S
E
-
I
I
A
E
T
G
A
G
Q
H
G
V
A
S
A
L
A
S
A
L
L
G
L
K
C
R
I
Y
M
G
A
K
D
V
E
R
--
Q
S
P
N
V
F
R
M
R
L
M
G
A
E
V
I
P
-----
V
H
S
G
S
----------
A
T
L
K
D
A
C
N
E
A
L
R
D
W
S
G
S
Y
E
T
A
H
Y
M
L
G
T
A
A
G
P
H
P
Y
P
T
I
V
R
E
F
Q
R
M
I
G
E
E
T
K
A
Q
I
L
D
K
E
G
R
L
P
D
A
V
I
A
C
V
G
G
G
S
N
A
I
G
M
F
A
D
F
I
---
N
-
D
T--
S
V
G
L
I
G
V
E
----
P
G
G
H
G
I
E
T
G
E
H
--
G
A
P
L
K
H
----
G
R
V
G
I
Y
F
G
M
K
A
P
M
M
Q
T
A
D
G
Q
I
E
E
S
Y
S
I
S
A
G
L
D
F
P
S
V
G
P
Q
H
A
Y
L
N
S
I
G
R
A
D
Y
V
S
I
T
D
D
E
A
L
E
A
F
K
T
L
C
R
H
E
G
I
I
P
A
L
E
S
S
H
A
L
A
H
A
L
K
M
M
R
E
Q
P
E
K
---
E
Q
L
L
V
V
N
L
S
G
R
G
D
K
D
I
F
T
V
H
D
-----------
69
PsiBlast_CBE
87.25
50%
-62
- C3 -
3PR2
5
TRPB_SALTY
B:
[6-389]
-------------
Y
F
G
E
F
G
G
M
Y
V
P
Q
I
L
M
P
A
L
N
Q
L
E
E
A
F
V
S
A
Q
K
D
P
E
F
Q
A
Q
F
A
D
L
L
K
N
Y
A
G
R
P
T
A
L
T
K
C
Q
N
I
T
A
G
T
R
--
T
T
L
Y
L
K
R
E
D
L
L
H
G
G
A
H
K
T
N
Q
V
L
G
Q
A
L
L
A
K
R
M
G
K
S
E
-
I
I
A
E
T
G
A
G
Q
H
G
V
A
S
A
L
A
S
A
L
L
G
L
K
C
R
I
Y
M
G
A
K
D
V
E
R
--
Q
S
P
N
V
F
R
M
R
L
M
G
A
E
V
I
P
-----
V
H
S
G
S
----------
A
T
L
K
D
A
C
N
E
A
L
R
D
W
S
G
S
Y
E
T
A
H
Y
M
L
G
T
A
A
G
P
H
P
Y
P
T
I
V
R
E
F
Q
R
M
I
G
E
E
T
K
A
Q
I
L
D
K
E
G
R
L
P
D
A
V
I
A
C
V
G
G
G
S
N
A
I
G
M
F
A
D
F
I
---
N
-
D
T--
S
V
G
L
I
G
V
E
----
P
G
G
H
G
I
E
T
G
E
H
--
G
A
P
L
K
H
----
G
R
V
G
I
Y
F
G
M
K
A
P
M
M
Q
T
A
D
G
Q
I
E
E
S
Y
S
I
S
A
G
L
D
F
P
S
V
G
P
Q
H
A
Y
L
N
S
I
G
R
A
D
Y
V
S
I
T
D
D
E
A
L
E
A
F
K
T
L
C
R
H
E
G
I
I
P
A
L
E
S
S
H
A
L
A
H
A
L
K
M
M
R
E
Q
P
E
K
---
E
Q
L
L
V
V
N
L
S
G
R
G
D
K
D
I
F
T
V
H
D
I
L
---------
44
PsiBlast_CBE
87.02
50%
-65
- C3 -
1CW2
2
TRPB_SALTY
B:
[8-389]
-------------
Y
F
G
E
F
G
G
M
Y
V
P
Q
I
L
M
P
A
L
N
Q
L
E
E
A
F
V
R
A
Q
K
D
P
E
F
Q
A
Q
F
A
D
L
L
K
N
Y
A
G
R
P
T
A
L
T
K
C
Q
N
I
T
A
G
T
R
--
T
T
L
Y
L
K
R
E
D
L
L
H
G
G
A
H
K
T
N
Q
V
L
G
Q
A
L
L
A
K
R
M
G
K
S
E
-
I
I
A
E
T
G
A
G
Q
H
G
V
A
S
A
L
A
S
A
L
L
G
L
K
C
R
I
Y
M
G
A
K
D
V
E
R
--
Q
S
P
N
V
F
R
M
R
L
M
G
A
E
V
I
P
-----
V
H
S
G
S
----------
A
T
L
K
D
A
C
N
E
A
L
R
D
W
S
G
S
Y
E
T
A
H
Y
M
L
G
T
A
A
G
P
H
P
Y
P
T
I
V
R
E
F
Q
R
M
I
G
E
E
T
K
A
Q
I
L
D
K
E
G
R
L
P
D
A
V
I
A
C
V
G
G
G
S
N
A
I
G
M
F
A
D
F
I
---
N
-
D
T--
S
V
G
L
I
G
V
E
----
P
G
G
H
G
I
E
T
G
E
H
--
G
A
P
L
K
H
----
G
R
V
G
I
Y
F
G
M
K
A
P
M
M
Q
T
A
D
G
Q
I
E
E
S
Y
S
I
S
A
G
L
D
F
P
S
V
G
P
Q
H
A
Y
L
N
S
I
G
R
A
D
Y
V
S
I
T
D
D
E
A
L
E
A
F
K
T
L
C
R
H
E
G
I
I
P
A
L
E
S
S
H
A
L
A
H
A
L
K
M
M
R
E
Q
P
E
K
---
E
Q
L
L
V
V
N
L
S
G
R
G
D
K
D
I
F
T
V
H
D
-----------
60
PsiBlast_CBE
86.49
50%
-65
- C3 -
2TSY
2
TRPB_SALTY
B:
[8-391]
-------------
Y
F
G
E
F
G
G
M
Y
V
P
Q
I
L
M
P
A
L
N
Q
L
E
E
A
F
V
R
A
Q
K
D
P
E
F
Q
A
Q
F
A
D
L
L
K
N
Y
A
G
R
P
T
A
L
T
K
C
Q
N
I
T
A
G
T
R
--
T
T
L
Y
L
K
R
E
D
L
L
H
G
G
A
H
T
T
N
Q
V
L
G
Q
A
L
L
A
K
R
M
G
K
S
E
-
I
I
A
E
T
G
A
G
Q
H
G
V
A
S
A
L
A
S
A
L
L
G
L
K
C
R
I
Y
M
G
A
K
D
V
E
R
--
Q
S
P
N
V
F
R
M
R
L
M
G
A
E
V
I
P
-----
V
H
S
G
S
----------
A
T
L
K
D
A
C
N
E
A
L
R
D
W
S
G
S
Y
E
T
A
H
Y
M
L
G
T
A
A
G
P
H
P
Y
P
T
I
V
R
E
F
Q
R
M
I
G
E
E
T
K
A
Q
I
L
D
K
E
G
R
L
P
D
A
V
I
A
C
V
G
G
G
S
N
A
I
G
M
F
A
D
F
I
---
N
-
D
T--
S
V
G
L
I
G
V
E
----
P
G
G
H
G
I
E
T
G
E
H
--
G
A
P
L
K
H
----
G
R
V
G
I
Y
F
G
M
K
A
P
M
M
Q
T
A
D
G
Q
I
E
E
S
Y
S
I
S
A
G
L
D
F
P
S
V
G
P
Q
H
A
Y
L
N
S
I
G
R
A
D
Y
V
S
I
T
D
D
E
A
L
E
A
F
K
T
L
C
R
H
E
G
I
I
P
A
L
E
S
S
H
A
L
A
H
A
L
K
M
M
R
E
Q
P
E
K
---
E
Q
L
L
V
V
N
L
S
G
R
G
D
K
D
I
F
T
V
H
D
I
L
---------
50
PsiBlast_CBE
85.65
50%
-74
- C3 -
2WSY
2
TRPB_SALTY
B:
[7-387]
-------------
Y
F
G
E
F
G
G
M
Y
V
P
Q
I
L
M
P
A
L
N
Q
L
E
E
A
F
V
R
A
Q
K
D
P
E
F
Q
A
Q
F
A
D
L
L
K
N
Y
A
G
R
P
T
A
L
T
K
C
Q
N
I
T
A
G
T
R
--
T
T
L
Y
L
K
R
E
D
L
L
H
G
G
A
H
K
T
N
Q
V
L
G
Q
A
L
L
A
K
R
M
G
K
S
E
-
I
I
A
E
T
G
A
G
Q
H
G
V
A
S
A
L
A
S
A
L
L
G
L
K
C
R
I
Y
M
G
A
K
D
------
S
P
N
V
F
R
M
R
L
M
G
A
E
V
I
----------------------
T
L
K
D
A
C
N
E
A
L
R
D
W
S
G
S
Y
E
T
A
H
Y
M
L
G
T
A
A
G
P
H
P
Y
P
T
I
V
R
E
F
Q
R
M
I
G
E
E
T
K
A
Q
I
L
D
K
E
G
R
L
P
D
A
V
I
A
C
V
G
G
G
S
N
A
I
G
M
F
A
D
F
I
---
N
-
D
T--
S
V
G
L
I
G
V
E
----
P
G
G
H
G
I
E
T
G
E
H
--
G
A
P
L
K
H
----
G
R
V
G
I
Y
F
G
M
K
A
P
M
M
Q
T
A
D
G
Q
I
E
E
S
Y
S
I
S
A
G
L
D
F
P
S
V
G
P
Q
H
A
Y
L
N
S
I
G
R
A
D
Y
V
S
I
T
D
D
E
A
L
E
A
F
K
T
L
C
R
H
E
G
I
I
P
A
L
E
S
S
H
A
L
A
H
A
L
K
M
M
R
E
Q
P
E
K
---
E
Q
L
L
V
V
N
L
S
G
R
G
D
K
D
I
F
T
V
H
------------
122
Fugue
85.53
47%
-60
- C3 -
2TYS
2
TRPB_SALTY
B:
[3-397]
------
T
L
L
N
--
P
Y
F
G
E
F
G
G
M
Y
V
P
Q
I
L
M
P
A
L
N
Q
L
E
E
A
F
V
R
A
Q
K
D
P
E
F
Q
A
Q
F
A
D
L
L
K
N
Y
A
G
R
P
T
A
L
T
K
C
Q
N
I
T
A
G
T
R
--
T
T
L
Y
L
K
R
E
D
L
L
H
G
G
A
H
T
T
N
Q
V
L
G
Q
A
L
L
A
K
R
M
G
K
S
-
E
I
I
A
E
T
G
A
G
Q
H
G
V
A
S
A
L
A
S
A
L
L
G
L
K
C
R
I
Y
M
G
A
K
D
V
E
R
--
Q
S
P
N
V
F
R
M
R
L
M
G
A
E
V
I
P
-----
V
H
S
G
S
----------
A
T
L
K
D
A
C
N
E
A
L
R
D
W
S
G
S
Y
E
T
A
H
Y
M
L
G
T
A
A
G
P
H
P
Y
P
T
I
V
R
E
F
Q
R
M
I
G
E
E
T
K
A
Q
I
L
D
K
E
G
R
L
P
D
A
V
I
A
C
V
G
G
G
S
N
A
I
G
M
F
A
D
F
I
---
N
D
T
---
S
V
G
L
I
G
V
E
----
P
G
G
H
G
I
E
T
G
E
H
GA
P
L
K
H
G
------
R
V
G
I
Y
F
G
M
K
A
P
M
M
Q
T
A
D
G
Q
I
E
E
S
Y
S
I
S
A
G
L
D
F
P
S
V
G
P
Q
H
A
Y
L
N
S
I
G
R
A
D
Y
V
S
I
T
D
D
E
A
L
E
A
F
K
T
L
C
R
H
E
G
I
I
P
A
L
E
S
S
H
A
L
A
H
-
A
L
K
M
M
R
E
Q
P
E
---
K
E
Q
L
L
V
V
N
L
S
G
R
G
--
D
K
D
I
F
T
V
H
D
I
L
K
A
R
G
E
I
71
PsiBlast_CBE
66.12
31%
-50
- C3 -
4QYS
1
TRPB2_SULSO
B:
[45-419]
------------------------
E
V
L
P
S
K
V
L
E
L
E
F
A
K
E
R
Y
V
K
I
P
D
--
E
V
L
E
R
Y
L
Q
--
V
G
R
P
T
P
I
I
R
A
K
R
L
E
E
Y
L
G
N
N
I
K
I
Y
L
K
M
E
S
Y
T
Y
T
G
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----------------