@TOME V2.3
(Nov 2016)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : SA1287: (2016-03-24 )
MKTTIKQAKDHLNQDVTIGAWLTNKRSSGKIAFLQLRDGTGFMQGVVVKSEVDEEVFKLAKEIAQESSLYVTGTITEDNRSDLGYEMQVKSIEVISEAHDYPITPKNHGTEFLMDHRHLWLRSKKQHAVMKIRNEVIRATYEFFNKDGFTKVDPPILTASAPEGTSELFHTKYFDQDAFLSQSGQLYLEAAAMAHGKVFSFGPTFRAEKSKTRRHLIEFWMIEGEMAFTNHAESLEIQEQYVTHVVKSVLENCKLELKILERDTSKLEKVATPFPRISYDDAIEFLKAEGFDDIEWGEDFGAPHETAIANHYDLPVFITNYPTKIKPFYMQPNPENEETVLCADLIAPEGYGEIIGGSERVDDLELLEQRVKEHGLDEEAYSYYLDLRRYGSVPHCGFGLGLERTVAWISGVEHVRETAPFPRLLNRLYP
Atome Classification :
(25 SA)
-----------.........10-..-......20........-30.........40........50--........60........70......--..80--.--------.--------.......90.....-------------..-.100..-----..---.---...-----110.---......120.......130.......140.......150.......160.......170.......180.......190...-..--...200.......210.......220......-.-230.......240.......250....--...260.......270.......280.....--..290-----..-----......300..-------------------.....310--.----.-...-...320.......330.......340.......350-.......360.......370.......-----380.......390.......400.......410.......420.......430
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
-----------MK
T
T
I
K
Q
A
K
D
H-LN-QD
V
T
I
G
A
W
L
TNKRSSG-
K
-
I
A
F
L
Q
LRDGTG
F
M
Q
G
V
V
V
K
S
E
--
V
D
E
E
V
F
K
L
A
K
E
I
AQES
S
L
Y
V
T
G
T
ITE--DNR---S--------D--------LG
Y
E
M
Q
V
K
S
I
E
V
I
S
-------------EA-HD-YPI-----TP---K---NH
G
-----
T
E
F
L
---
M
D
H
R
H
L
W
L
R
SKK
Q
H
A
V
M
K
I
R
N
E
V
I
R
A
T
Y
E
F
FNKDGFTKVDPP
I
L
TASAPE
G
T
S
E
L
F
H
T
KYFDQ
D
A
F
LSQSG
Q
L
Y
L
E
A
A
-
A
MA-HG--
K
V
F
SFGPTFR
A
E
K
S
K
T
R
R
H
L
I
E
F
W
M
IEGEMAF-T-NHA
E
S
L
E
I
Q
E
Q
Y
V
T
H
V
V
K
S
V
L
ENC
K
L
E
--
L
K
I
LER
D
T
S
K
L
E
K
V
ATPFPRI
S
Y
D
D
A
I
E
F
L
K
--AEGF------DD-----IEWGEDFGAPH-------------------
E
T
AIANH---Y----D-L
P
V
-
F
I
TNYPTK
I
K
P
F
Y
MQPNPENE
E
T
V
L
C
A
D
LIAPEG
Y
G
-
E
IIGGSERV
D
D
L
E
L
L
E
Q
R
V
K
EHGL
D
E
E
-----
A
Y
S
Y
Y
L
D
L
R
RYGSVPHCGFGL
G
L
E
R
T
V
A
W
I
S
G
V
E
H
V
R
ETA
P
F
P
R
L
L
N
R
LYP
2
PsiBlast_PDB
98.50
45%
-79
- C4 -
1X55
4
SYN_PYRHO
A:
[4-434]
------------
K
V
Y
C
Q
E
V
K
P
E
-
L
D
G
K
K
V
R
L
A
G
W
V
Y
T
N
M
R
V
G
-
K
-
K
I
F
L
W
I
R
D
S
T
G
I
V
Q
A
V
V
A
K
N
V
--
V
G
E
E
T
F
E
K
A
K
K
L
G
R
E
S
S
V
I
V
E
G
I
V
K
A
--
D
E
R
---
A
--------
P
--------
G
G
A
E
V
H
V
E
K
L
E
V
I
Q
-------------
A
V
-
S
E
-
F
P
I
PE---
N
P
---
E
---
Q
A
S
-----
P
E
L
L
---
L
D
Y
R
H
L
H
I
R
T
P
K
A
S
A
I
M
K
V
K
E
T
L
I
M
A
A
R
E
W
L
L
K
D
G
W
H
E
V
F
P
P
I
L
V
T
G
A
V
E
G
G
A
T
L
F
K
L
K
Y
F
D
K
Y
A
Y
L
S
Q
S
A
Q
L
Y
L
E
A
A
-
I
F
G
-
L
E
--
K
V
W
S
L
T
P
S
F
R
A
E
K
S
R
T
R
R
H
L
T
E
F
W
H
L
E
L
E
A
A
W
-
M
-
D
L
W
D
I
M
K
V
E
E
E
L
V
S
Y
M
V
Q
R
T
L
E
L
R
K
K
E
--
I
E
M
F
R
D
D
L
T
T
L
K
N
T
E
P
P
F
P
R
I
S
Y
D
E
A
I
D
I
L
Q
--
S
K
G
V
-------
N
-----
V
E
W
G
D
D
L
G
A
D
E
-------------------
E
R
V
L
T
E
E
---
F
----
D
-
R
P
F
-
F
V
Y
G
Y
P
K
H
I
K
A
F
Y
M
K
E
D
P
N
D
P
R
K
V
L
A
S
D
M
L
A
P
E
G
Y
G
-
E
I
I
G
G
S
Q
R
E
D
D
Y
D
K
L
L
N
R
I
L
E
E
G
M
D
P
K
-----
D
Y
E
W
Y
L
D
L
R
R
Y
G
S
V
P
H
S
G
F
G
L
G
V
E
R
L
V
A
W
V
L
K
L
D
H
I
R
W
A
A
L
F
P
R
T
P
A
R
L
Y
P
1
PsiBlast_PDB
98.41
45%
-82
- C4 -
1X54
3
SYN_PYRHO
A:
[4-434]
------------
K
V
Y
C
Q
E
V
K
P
E
-
L
D
G
K
K
V
R
L
A
G
W
V
Y
T
N
M
R
V
G
-
K
-
K
I
F
L
W
I
R
D
S
T
G
I
V
Q
A
V
V
A
K
N
V
--
V
G
E
E
T
F
E
K
A
K
K
L
G
R
E
S
S
V
I
V
E
G
I
V
K
A
--
D
E
R
---
A
--------
P
--------
G
G
A
E
V
H
V
E
K
L
E
V
I
Q
-------------
A
V
-
S
E
-
F
P
I
PE---
N
P
---
E
---
Q
A
S
-----
P
E
L
L
---
L
D
Y
R
H
L
H
I
R
T
P
K
A
S
A
I
M
K
V
K
E
T
L
I
M
A
A
R
E
W
L
L
K
D
G
W
H
E
V
F
P
P
I
L
V
T
G
A
V
E
G
G
A
T
L
F
K
L
K
Y
F
D
K
Y
A
Y
L
S
Q
S
A
Q
L
Y
L
E
A
A
-
I
F
G
-
L
E
--
K
V
W
S
L
T
P
S
F
R
A
E
K
S
R
T
R
R
H
L
T
E
F
W
H
L
E
L
E
A
A
W
-
M
-
D
L
W
D
I
M
K
V
E
E
E
L
V
S
Y
M
V
Q
R
T
L
E
L
R
K
K
E
--
I
E
M
F
R
D
D
L
T
T
L
K
N
T
E
P
P
F
P
R
I
S
Y
D
E
A
I
D
I
L
Q
--
S
K
G
V
-------
N
-----
V
E
W
G
D
D
L
G
A
D
E
-------------------
E
R
V
L
T
E
E
---
F
----
D
-
R
P
F
-
F
V
Y
G
Y
P
K
H
I
K
A
F
Y
M
K
E
D
P
N
D
P
R
K
V
L
A
S
D
M
L
A
P
E
G
Y
G
-
E
I
I
G
G
S
Q
R
E
D
D
Y
D
K
L
L
N
R
I
L
E
E
G
M
D
P
K
-----
D
Y
E
W
Y
L
D
L
R
R
Y
G
S
V
P
H
S
G
F
G
L
G
V
E
R
L
V
A
W
V
L
K
L
D
H
I
R
W
A
A
L
F
P
R
T
P
A
R
L
Y
P
29
HHSearch
97.96
46%
-80
- C4 -
1X54
3
SYN_PYRHO
A:
[3-434]
-----------
E
K
V
Y
C
Q
E
V
K
P
E
L
D
G
-
K
K
V
R
L
A
G
W
V
Y
T
N
M
R
V
G
-
K
-
K
I
F
L
W
I
R
D
S
T
G
I
V
Q
A
V
V
A
K
N
V
--
V
G
E
E
T
F
E
K
A
K
K
L
G
R
E
S
S
V
I
V
E
G
I
V
K
A
--
D
E
R
---
A
--------
P
--------
G
G
A
E
V
H
V
E
K
L
E
V
I
Q
-------------
A
V
-
S
E
-
F
P
I
-----
P
E
NP-
E
---
Q
A
S
-----
P
E
L
L
---
L
D
Y
R
H
L
H
I
R
T
P
K
A
S
A
I
M
K
V
K
E
T
L
I
M
A
A
R
E
W
L
L
K
D
G
W
H
E
V
F
P
P
I
L
V
T
G
A
V
E
G
G
A
T
L
F
K
L
K
Y
F
D
K
Y
A
Y
L
S
Q
S
A
Q
L
Y
L
E
A
A
-
I
F
G
-
L
E
--
K
V
W
S
L
T
P
S
F
R
A
E
K
S
R
T
R
R
H
L
T
E
F
W
H
L
E
L
E
A
A
W
-
M
-
D
L
W
D
I
M
K
V
E
E
E
L
V
S
Y
M
V
Q
R
T
L
E
L
R
K
K
E
--
I
E
M
F
R
D
D
L
T
T
L
K
N
T
E
P
P
F
P
R
I
S
Y
D
E
A
I
D
I
L
Q
--
S
K
G
V
------
N
V
------
E
W
G
D
D
L
G
A
D
E
-------------------
E
R
V
L
T
E
E
---
F
----
D
-
R
P
F
-
F
V
Y
G
Y
P
K
H
I
K
A
F
Y
M
K
E
D
P
N
D
P
R
K
V
L
A
S
D
M
L
A
P
E
G
Y
G
-
E
I
I
G
G
S
Q
R
E
D
D
Y
D
K
L
L
N
R
I
L
E
E
G
M
D
P
K
-----
D
Y
E
W
Y
L
D
L
R
R
Y
G
S
V
P
H
S
G
F
G
L
G
V
E
R
L
V
A
W
V
L
K
L
D
H
I
R
W
A
A
L
F
P
R
T
P
A
R
L
Y
P
3
PsiBlast_PDB
96.11
45%
-90
- C4 -
1X56
-
SYN_PYRHO
A:
[4-434]
------------
K
V
Y
C
Q
E
V
K
P
E
-
L
D
G
K
K
V
R
L
A
G
W
V
Y
T
N
M
R
V
G
-
K
-
K
I
F
L
W
I
R
D
S
T
G
I
V
Q
A
V
V
A
K
N
V
--
V
G
E
E
T
F
E
K
A
K
K
L
G
R
E
S
S
V
I
V
E
G
I
V
K
A
--
D
E
R
---
A
--------
P
--------
G
G
A
E
V
H
V
E
K
L
E
V
I
Q
-------------
A
V
-
S
E
-
F
P
I
PE---
N
P
---
E
---
Q
A
S
-----
P
E
L
L
---
L
D
Y
R
H
L
H
I
R
T
P
K
A
S
A
I
M
K
V
K
E
T
L
I
M
A
A
R
E
W
L
L
K
D
G
W
H
E
V
F
P
P
I
L
V
T
--------
L
F
K
L
K
Y
F
D
K
Y
A
Y
L
S
Q
S
A
Q
L
Y
L
E
A
A
-
I
F
G
-
L
E
--
K
V
W
S
L
T
P
S
F
R
A
E
------
H
L
T
E
F
W
H
L
E
L
E
A
A
W
-
M
-
D
L
W
D
I
M
K
V
E
E
E
L
V
S
Y
M
V
Q
R
T
L
E
L
R
K
K
E
--
I
E
M
F
R
D
D
L
T
T
L
K
N
T
E
P
P
F
P
R
I
S
Y
D
E
A
I
D
I
L
Q
--
S
K
G
V
-------
N
-----
V
E
W
G
D
D
L
G
A
D
E
-------------------
E
R
V
L
T
E
E
---
F
----
D
-
R
P
F
-
F
V
Y
G
Y
P
K
H
I
K
A
F
Y
M
K
E
D
P
N
D
P
R
K
V
L
A
S
D
M
L
A
P
E
G
Y
G
-
E
I
I
G
G
S
Q
R
E
D
D
Y
D
K
L
L
N
R
I
L
E
E
G
M
D
P
K
-----
D
Y
E
W
Y
L
D
L
R
R
Y
G
S
V
P
H
S
G
F
G
L
G
V
E
R
L
V
A
W
V
L
K
L
D
H
I
R
W
A
A
L
F
P
R
T
P
A
R
L
Y
P
4
PsiBlast_PDB
89.29
36%
-75
- C4 -
3NEL
1
SYD_THEKO
A:
[17-438]
--------------------------
Q
K
V
K
V
A
G
W
V
W
E
V
K
D
L
G
-
G
-
I
K
F
L
W
I
R
D
R
D
G
I
V
Q
I
T
A
P
K
K
K
--
V
D
P
E
L
F
K
L
I
P
K
L
R
S
E
D
V
V
A
V
E
G
V
V
N
F
--
T
P
K
---
A
--------
K
--------
L
G
F
E
I
L
P
E
K
I
V
V
L
N
-------------
R
A
-
E
T
P
L
P
L
-----
D
P
---
T
---
G
K
V
-----
K
A
E
L
D
T
R
L
D
N
R
F
M
D
L
R
R
P
E
V
M
A
I
F
K
I
R
S
S
V
F
K
A
V
R
D
F
F
H
E
N
G
F
I
E
I
H
T
P
K
I
I
A
T
A
T
E
G
G
T
E
L
F
P
M
K
Y
F
E
E
D
A
F
L
A
Q
S
P
Q
L
Y
-
K
Q
I
-
M
M
A
-
S
G
LD
R
V
Y
E
I
A
P
I
F
R
A
E
E
H
N
T
T
R
H
L
N
E
A
W
S
I
D
S
E
M
A
F
-
I
E
D
E
E
E
V
M
S
F
L
E
R
L
V
A
H
A
I
N
Y
V
R
E
H
N
A
K
E
--
L
D
I
L
---
N
F
E
L
E
E
P
K
L
P
F
P
R
V
S
Y
D
K
A
L
E
I
L
G
--
D
L
G
-------
K
E
-----
I
P
W
G
E
D
I
D
T
E
G
-------------------
E
R
L
L
G
K
Y
---
M
M
E
N
E
N
-
A
P
L
Y
F
L
Y
Q
Y
P
S
E
A
K
P
F
Y
I
M
K
Y
D
N
K
P
E
I
C
R
A
F
D
L
---
E
Y
R
G
V
E
I
S
S
G
G
Q
R
E
H
R
H
D
I
L
V
E
Q
I
K
E
K
G
L
N
P
E
-----
S
F
E
F
Y
L
K
A
F
R
Y
G
M
P
P
H
G
G
F
G
L
G
A
E
R
L
I
K
Q
M
L
D
L
P
N
I
R
E
V
I
L
F
P
R
D
R
R
R
L
T
P
5
PsiBlast_PDB
89.07
36%
-76
- C4 -
3NEM
1
SYD_THEKO
A:
[17-438]
--------------------------
Q
K
V
K
V
A
G
W
V
W
E
V
K
D
L
G
-
G
-
I
K
F
L
W
I
R
D
R
D
G
I
V
Q
I
T
A
P
K
K
K
--
V
D
P
E
L
F
K
L
I
P
K
L
R
S
E
D
V
V
A
V
E
G
V
V
N
F
--
T
P
K
---
A
--------
K
--------
L
G
F
E
I
L
P
E
K
I
V
V
L
N
-------------
R
A
-
E
T
P
L
P
L
-----
D
P
---
T
---
G
K
V
-----
K
A
E
L
D
T
R
L
D
N
R
F
M
D
L
R
R
P
E
V
M
A
I
F
K
I
R
S
S
V
F
K
A
V
R
D
F
F
H
E
N
G
F
I
E
I
H
T
P
K
I
I
A
T
A
T
E
G
G
T
E
L
F
P
M
K
Y
F
E
E
D
A
F
L
A
Q
S
P
Q
L
Y
-
K
Q
I
-
M
M
A
-
S
G
LD
R
V
Y
E
I
A
P
I
F
R
A
E
E
H
N
T
T
R
H
L
N
E
A
W
S
I
D
S
E
M
A
F
-
I
E
D
E
E
E
V
M
S
F
L
E
R
L
V
A
H
A
I
N
Y
V
R
E
H
N
A
K
E
--
L
D
I
L
---
N
F
E
L
E
E
P
K
L
P
F
P
R
V
S
Y
D
K
A
L
E
I
L
G
--
D
L
G
-------
K
E
-----
I
P
W
G
E
D
I
D
T
E
G
-------------------
E
R
L
L
G
K
Y
---
M
M
E
NE
N
-
A
P
L
Y
F
L
Y
Q
Y
P
S
E
A
K
P
F
Y
I
M
K
Y
D
N
K
P
E
I
C
R
A
F
D
L
---
E
Y
R
G
V
E
I
S
S
G
G
Q
R
E
H
R
H
D
I
L
V
E
Q
I
K
E
K
G
L
N
P
E
-----
S
F
E
F
Y
L
K
A
F
R
Y
G
M
P
P
H
G
G
F
G
L
G
A
E
R
L
I
K
Q
M
L
D
L
P
N
I
R
E
V
I
L
F
P
R
D
R
R
R
L
T
P
7
PsiBlast_PDB
89.05
36%
-78
- C4 -
1B8A
4
SYD_THEKO
A:
[17-438]
--------------------------
Q
K
V
K
V
A
G
W
V
W
E
V
K
D
L
G
-
G
-
I
K
F
L
W
I
R
D
R
D
G
I
V
Q
I
T
A
P
K
K
K
--
V
D
P
E
L
F
K
L
I
P
K
L
R
S
E
D
V
V
A
V
E
G
V
V
N
F
--
T
P
K
---
A
--------
K
--------
L
G
F
E
I
L
P
E
K
I
V
V
L
N
-------------
R
A
-
E
T
P
L
P
L
-----
D
P
---
T
---
G
K
V
-----
K
A
E
L
D
T
R
L
N
N
R
F
M
D
L
R
R
P
E
V
M
A
I
F
K
I
R
S
S
V
F
K
A
V
R
D
F
F
H
E
N
G
F
I
E
I
H
T
P
K
I
I
A
T
A
T
E
G
G
T
E
L
F
P
M
K
Y
F
E
E
D
A
F
L
A
E
S
P
Q
L
Y
K
E
-
I
-
M
M
A
-
S
G
LD
R
V
Y
E
I
A
P
I
F
R
A
E
E
H
N
T
T
R
H
L
N
E
A
W
S
I
D
S
E
M
A
F
-
I
E
D
E
E
E
V
M
S
F
L
E
R
L
V
A
H
A
I
N
Y
V
R
E
H
N
A
K
E
--
L
D
I
L
---
N
F
E
L
E
E
P
K
L
P
F
P
R
V
S
Y
D
K
A
L
E
I
L
G
--
D
L
G
-------
K
E
-----
I
P
W
G
E
D
I
D
T
E
G
-------------------
E
R
L
L
G
K
Y
---
M
M
E
N
E
N
-
A
P
L
Y
F
L
Y
Q
Y
P
S
E
A
K
P
F
Y
I
M
K
Y
D
N
K
P
E
I
C
R
A
F
D
L
---
E
Y
R
G
V
E
I
S
S
G
G
Q
R
E
H
R
H
D
I
L
V
E
Q
I
K
E
K
G
L
N
P
E
-----
S
F
E
F
Y
L
K
A
F
R
Y
G
M
P
P
H
G
G
F
G
L
G
A
E
R
L
I
K
Q
M
L
D
L
P
N
I
R
E
V
I
L
F
P
R
D
R
R
R
L
T
P
22
PsiBlast_CBE
88.81
36%
-76
- C4 -
1B8A
3
SYD_THEKO
B:
[17-438]
--------------------------
Q
K
V
K
V
A
G
W
V
W
E
V
K
D
L
G
-
G
-
I
K
F
L
W
I
R
D
R
D
G
I
V
Q
I
T
A
P
K
K
K
--
V
D
P
E
L
F
K
L
I
P
K
L
R
S
E
D
V
V
A
V
E
G
V
V
N
F
--
T
P
K
---
A
--------
K
--------
L
G
F
E
I
L
P
E
K
I
V
V
L
N
-------------
R
A
-
E
T
P
L
P
L
-----
D
P
---
T
---
G
K
V
-----
K
A
E
L
DTR
L
N
N
R
F
M
D
L
R
R
P
E
V
M
A
I
F
K
I
R
S
S
V
F
K
A
V
R
D
F
F
H
E
N
G
F
I
E
I
H
T
P
K
I
I
A
T
A
T
E
G
G
T
E
L
F
P
M
K
Y
F
E
E
D
A
F
L
A
E
S
P
Q
L
Y
K
E
-
I
-
M
M
A
-
S
G
LD
R
V
Y
E
I
A
P
I
F
R
A
E
E
H
N
T
T
R
H
L
N
E
A
W
S
I
D
S
E
M
A
F
-
I
E
D
E
E
E
V
M
S
F
L
E
R
L
V
A
H
A
I
N
Y
V
R
E
H
N
A
K
E
--
L
D
I
L
---
N
F
E
L
E
E
P
K
L
P
F
P
R
V
S
Y
D
K
A
L
E
I
L
G
--
D
L
G
-------
K
E
-----
I
P
W
G
E
D
I
D
T
E
G
-------------------
E
R
L
L
G
K
Y
---
M
MENE
N
-
A
P
L
Y
F
L
Y
Q
Y
P
S
E
A
K
P
F
Y
I
M
K
Y
D
N
K
P
E
I
C
R
A
F
D
L
---
E
Y
R
G
V
E
I
S
S
G
G
Q
R
E
H
R
H
D
I
L
V
E
Q
I
K
E
K
G
L
N
P
E
-----
S
F
E
F
Y
L
K
A
F
R
Y
G
M
P
P
H
G
G
F
G
L
G
A
E
R
L
I
K
Q
M
L
D
L
P
N
I
R
E
V
I
L
F
P
R
D
R
R
R
L
T
P
6
PsiBlast_PDB
88.74
36%
-74
- C4 -
3NEN
-
SYD_THEKO
A:
[17-438]
--------------------------
Q
K
V
K
V
A
G
W
V
W
E
V
K
D
L
G
-
G
-
I
K
F
L
W
I
R
D
R
D
G
I
V
Q
I
T
A
P
K
K
K
--
V
D
P
E
L
F
K
L
I
P
K
L
R
S
E
D
V
V
A
V
E
G
V
V
N
F
--
T
P
K
---
A
--------
K
--------
L
G
F
E
I
L
P
E
K
I
V
V
L
N
-------------
R
A
-
E
T
P
L
P
L
-----
D
P
---
T
---
G
K
V
-----
K
A
E
L
D
T
R
L
D
N
R
F
M
D
L
R
R
P
E
V
M
A
I
F
K
I
R
S
S
V
F
K
A
V
R
D
F
F
H
E
N
G
F
I
E
I
H
T
P
K
I
I
A
T
A
T
E
G
G
T
E
L
F
P
M
K
Y
F
E
E
D
A
F
L
A
Q
S
P
Q
L
Y
-
K
Q
I
-
M
M
A
-
S
G
LD
R
V
Y
E
I
A
P
I
F
R
A
E
E
H
N
T
T
R
H
L
N
E
A
W
S
I
D
S
E
M
A
F
-
I
E
D
E
E
E
V
M
S
F
L
E
R
L
V
A
H
A
I
N
Y
V
R
E
H
N
A
K
E
--
L
D
I
L
---
N
F
E
L
E
E
P
K
L
P
F
P
R
V
S
Y
D
K
A
L
E
I
L
G
--
D
L
G
-------
K
E
-----
I
P
W
G
E
D
I
D
T
E
G
-------------------
E
R
L
L
G
K
Y
---
M
M
E
N
E
N
-
A
P
L
Y
F
L
Y
Q
Y
P
S
E
A
K
P
F
Y
I
M
K
Y
D
N
K
P
E
I
C
R
A
F
D
L
---
E
Y
R
G
V
E
I
S
S
G
G
Q
R
E
H
R
H
D
I
L
V
E
Q
I
K
E
K
G
L
N
P
E
-----
S
F
E
F
Y
L
K
A
F
R
Y
G
M
P
P
H
G
G
F
G
L
G
A
E
R
L
I
K
Q
M
L
D
L
P
N
I
R
E
V
I
L
F
P
R
D
R
R
R
L
T
P
21
PsiBlast_CBE
88.63
36%
-73
- C4 -
3NEM
3
SYD_THEKO
B:
[17-438]
--------------------------
Q
K
V
K
V
A
G
W
V
W
E
V
K
D
L
G
-
G
-
I
K
F
L
W
I
R
D
R
D
G
I
V
Q
I
T
A
P
K
K
K
--
V
D
P
E
L
F
K
L
I
P
K
L
R
S
E
D
V
V
A
V
E
G
V
V
N
F
--
T
P
K
---
A
--------
K
--------
L
G
F
E
I
L
P
E
K
I
V
V
L
N
-------------
R
A
-
E
T
P
L
P
L
-----
D
P
---
T
---
G
K
V
-----
K
A
E
L
DTR
L
D
N
R
F
M
D
L
R
R
P
E
V
M
A
I
F
K
I
R
S
S
V
F
K
A
V
R
D
F
F
H
E
N
G
F
I
E
I
H
T
P
K
I
I
A
T
A
T
E
G
G
T
E
L
F
P
M
K
Y
F
E
E
D
A
F
L
A
Q
S
P
Q
L
Y
-
K
Q
I
-
M
M
A
-
S
G
LD
R
V
Y
E
I
A
P
I
F
R
A
E
E
H
N
T
T
R
H
L
N
E
A
W
S
I
D
S
E
M
A
F
-
I
E
D
E
E
E
V
M
S
F
L
E
R
L
V
A
H
A
I
N
Y
V
R
E
H
N
A
K
E
--
L
D
I
L
---
N
F
E
L
E
E
P
K
L
P
F
P
R
V
S
Y
D
K
A
L
E
I
L
G
--
D
L
G
-------
K
E
-----
I
P
W
G
E
D
I
D
T
E
G
-------------------
E
R
L
L
G
K
Y
---
M
MENE
N
-
A
P
L
Y
F
L
Y
Q
Y
P
S
E
A
K
P
F
Y
I
M
K
Y
D
N
K
P
E
I
C
R
A
F
D
L
---
E
Y
R
G
V
E
I
S
S
G
G
Q
R
E
H
R
H
D
I
L
V
E
Q
I
K
E
K
G
L
N
P
E
-----
S
F
E
F
Y
L
K
A
F
R
Y
G
M
P
P
H
G
G
F
G
L
G
A
E
R
L
I
K
Q
M
L
D
L
P
N
I
R
E
V
I
L
F
P
R
D
R
R
R
L
T
P
31
HHSearch
88.17
35%
-74
- C4 -
3NEM
1
SYD_THEKO
A:
[4-438]
------------
T
H
Y
S
S
E
I
T
E
E
L
N
G
-
Q
K
V
K
V
A
G
W
V
W
E
V
K
D
L
G
-
G
-
I
K
F
L
W
I
R
D
R
D
G
I
V
Q
I
T
A
P
K
K
K
--
V
D
P
E
L
F
K
L
I
P
K
L
R
S
E
D
V
V
A
V
E
G
V
V
N
F
--
T
P
K
---
A
--------
K
--------
L
G
F
E
I
L
P
E
K
I
V
V
L
N
-------------
R
A
E
T
P
-
L
P
L
-----
D
P
---
T
GK
V
K
A
E
-----
L
D
T
R
---
L
D
N
R
F
M
D
L
R
R
P
E
V
M
A
I
F
K
I
R
S
S
V
F
K
A
V
R
D
F
F
H
E
N
G
F
I
E
I
H
T
P
K
I
I
A
T
A
T
E
G
G
T
E
L
F
P
M
K
Y
F
E
E
D
A
F
L
A
Q
S
P
Q
L
Y
K
Q
I
M
M
A
S
G
-
L
D
--
R
V
Y
E
I
A
P
I
F
R
A
E
E
H
N
T
T
R
H
L
N
E
A
W
S
I
D
S
E
M
A
F
-
I
E
D
E
E
E
V
M
S
F
L
E
R
L
V
A
H
A
I
N
Y
V
R
E
H
N
A
K
E
--
L
D
I
L
N
F
E
L
E
E
---
P
K
L
P
F
P
R
V
S
Y
D
K
A
L
E
I
L
G
--
D
L
G
K
------
E
I
------
P
W
G
E
D
I
D
T
E
G
-------------------
E
R
L
L
G
K
Y
---
M
M
E
NE
N
A
P
L
Y
-
F
L
Y
Q
Y
P
S
E
A
K
P
F
Y
I
M
K
Y
D
N
K
P
E
I
C
R
A
F
D
L
E
Y
R
-
G
V
--
E
I
S
S
G
G
Q
R
E
H
R
H
D
I
L
V
E
Q
I
K
E
K
G
L
N
P
E
-----
S
F
E
F
Y
L
K
A
F
R
Y
G
M
P
P
H
G
G
F
G
L
G
A
E
R
L
I
K
Q
M
L
D
L
P
N
I
R
E
V
I
L
F
P
R
D
R
R
R
L
T
P
24
PsiBlast_CBE
87.49
32%
-81
- C4 -
3M4P
5
?
D:
[20-456]
-------------
C
N
I
R
D
A
A
G
L
-
E
G
-
K
L
V
T
F
K
G
W
A
Y
H
I
R
K
A
R
-
K
T
L
I
F
V
E
L
R
D
G
S
G
Y
C
Q
C
V
I
F
G
K
E
--
L
C
E
P
--
E
K
V
K
L
L
T
R
E
C
S
L
E
I
T
G
R
L
N
A
--
Y
A
G
---
K
--------
N
HPPEIADI
L
N
L
E
M
Q
V
T
E
W
K
V
I
G
-------------
E
S
-----
P
I
DLENI
I
N
---
K
---
D
S
S
-----
I
P
Q
K
---
M
Q
N
R
H
I
V
I
R
S
E
H
T
Q
Q
V
L
Q
L
R
S
E
I
Q
W
Y
F
R
K
Y
Y
H
D
N
H
F
T
E
I
Q
P
P
T
I
V
K
T
------
T
L
F
K
L
Q
Y
F
N
E
P
A
Y
L
T
Q
S
S
Q
L
Y
L
E
S
V
-
I
A
S
-
L
G
--
K
S
F
C
M
L
S
S
Y
R
A
E
Q
S
R
T
V
R
H
L
A
E
Y
L
H
L
E
A
E
L
P
F
-
I
-
S
F
E
D
L
L
N
H
L
E
D
L
V
C
T
V
I
D
N
V
M
---
A
V
H
--
G
D
K
I
R
K
M
N
P
H
L
K
L
P
T
R
P
F
K
R
M
T
Y
A
D
A
I
K
Y
C
N
--
D
H
G
I
------
L
N
KDKP-
F
E
Y
G
E
D
I
S
E
K
P
-------------------
E
R
Q
M
T
D
E
---
I
----
G
-
C
P
I
-
F
M
I
H
F
P
S
K
M
K
A
F
Y
M
S
K
V
P
G
H
P
D
L
T
E
S
V
D
L
L
M
P
-
G
V
G
-
E
I
V
G
G
S
M
R
I
W
N
Y
D
E
L
M
G
A
Y
K
A
N
G
L
N
P
D
-----
P
Y
Y
W
Y
T
Q
Q
R
K
Y
G
S
C
P
H
G
G
Y
G
L
G
V
E
R
L
V
M
W
L
L
G
E
D
H
I
R
K
V
C
L
Y
P
R
Y
L
E
R
C
E
P
26
PsiBlast_CBE
87.45
32%
-82
- C4 -
3M4P
5
?
B:
[20-456]
-------------
C
N
I
R
D
A
A
G
L
-
E
G
-
K
L
V
T
F
K
G
W
A
Y
H
I
R
K
A
R
-
K
T
L
I
F
V
E
L
R
D
G
S
G
Y
C
Q
C
V
I
F
G
K
E
--
L
C
E
P
--
E
K
V
K
L
L
T
R
E
C
S
L
E
I
T
G
R
L
N
A
--
Y
A
G
---
K
--------
N
H
P
P
EIADI
L
N
L
E
M
Q
V
T
E
W
K
V
I
G
-------------
E
S
-----
P
I
DLENI
I
N
---
K
---
D
S
S
-----
I
P
Q
K
---
M
Q
N
R
H
I
V
I
R
S
E
H
T
Q
Q
V
L
Q
L
R
S
E
I
Q
W
Y
F
R
K
Y
Y
H
D
N
H
F
T
E
I
Q
P
P
T
I
V
K
T
------
T
L
F
K
L
Q
Y
F
N
E
P
A
Y
L
T
Q
S
S
Q
L
Y
L
E
S
V
-
I
A
S
-
L
G
--
K
S
F
C
M
L
S
S
Y
R
A
E
Q
S
R
T
V
R
H
L
A
E
Y
L
H
L
E
A
E
L
P
F
-
I
-
S
F
E
D
L
L
N
H
L
E
D
L
V
C
T
V
I
D
N
V
M
---
A
V
H
--
G
D
K
I
R
K
M
N
P
H
L
K
L
P
T
R
P
F
K
R
M
T
Y
A
D
A
I
K
Y
C
N
--
D
H
G
I
------
L
N
KDKP-
F
E
Y
G
E
D
I
S
E
K
P
-------------------
E
R
Q
M
T
D
E
---
I
----
G
-
C
P
I
-
F
M
I
H
F
P
S
K
M
K
A
F
Y
M
S
K
V
P
G
H
P
D
L
T
E
S
V
D
L
L
M
P
-
G
V
G
-
E
I
V
G
G
S
M
R
I
W
N
Y
D
E
L
M
G
A
Y
K
A
N
G
L
N
P
D
-----
P
Y
Y
W
Y
T
Q
Q
R
K
Y
G
S
C
P
H
G
G
Y
G
L
G
V
E
R
L
V
M
W
L
L
G
E
D
H
I
R
K
V
C
L
Y
P
R
Y
L
E
R
C
E
P
10
PsiBlast_PDB
87.39
32%
-82
- C4 -
3M4Q
-
?
A:
[15-451]
-------------
C
N
I
R
D
A
A
G
L
-
E
G
-
K
L
V
T
F
K
G
W
A
Y
H
I
R
K
A
R
-
K
T
L
I
F
V
E
L
R
D
G
S
G
Y
C
Q
C
V
I
F
G
K
E
--
L
C
E
P
--
E
K
V
K
L
L
T
R
E
C
S
L
E
I
T
G
R
L
N
A
--
Y
A
G
---
K
--------
N
HPPEIADI
L
N
L
E
M
Q
V
T
E
W
K
V
I
G
-------------
E
S
-----
P
I
D
L
E
N
I
I
N
---
K
---
D
S
S
-----
I
P
Q
K
---
M
Q
N
R
H
I
V
I
R
S
E
H
T
Q
Q
V
L
Q
L
R
S
E
I
Q
W
Y
F
R
K
Y
Y
H
D
N
H
F
T
E
I
Q
P
P
T
I
V
K
T
------
T
L
F
K
L
Q
Y
F
N
E
P
A
Y
L
T
Q
S
S
Q
L
Y
L
E
S
V
-
I
A
S
-
L
G
--
K
S
F
C
M
L
S
S
Y
R
A
E
------
H
L
A
E
Y
L
H
L
E
A
E
L
P
F
-
I
-
S
F
E
D
L
L
N
H
L
E
D
L
V
C
T
V
I
D
N
V
M
---
A
V
H
--
G
D
K
I
R
K
M
N
P
H
L
K
L
P
T
R
P
F
K
R
M
T
Y
A
D
A
I
K
Y
C
N
--
D
H
G
I
------
L
N
KD
K
P
-
F
E
Y
G
E
D
I
S
E
K
P
-------------------
E
R
Q
M
T
D
E
---
I
----
G
-
C
P
I
-
F
M
I
H
F
P
S
K
M
K
A
F
Y
M
S
K
V
P
G
H
P
D
L
T
E
S
V
D
L
L
M
P
-
G
V
G
-
E
I
V
G
G
S
M
R
I
W
N
Y
D
E
L
M
G
A
Y
K
A
N
G
L
N
P
D
-----
P
Y
Y
W
Y
T
Q
Q
R
K
Y
G
S
C
P
H
G
G
Y
G
L
G
V
E
R
L
V
M
W
L
L
G
E
D
H
I
R
K
V
C
L
Y
P
R
Y
L
E
R
C
E
P
9
PsiBlast_PDB
87.26
32%
-81
- C4 -
3M4P
5
?
A:
[20-456]
-------------
C
N
I
R
D
A
A
G
L
-
E
G
-
K
L
V
T
F
K
G
W
A
Y
H
I
R
K
A
R
-
K
T
L
I
F
V
E
L
R
D
G
S
G
Y
C
Q
C
V
I
F
G
K
E
--
L
C
E
P
--
E
K
V
K
L
L
T
R
E
C
S
L
E
I
T
G
R
L
N
A
--
Y
A
G
---
K
--------
N
HPPEIADI
L
N
L
E
M
Q
V
T
E
W
K
V
I
G
-------------
E
S
-----
P
I
DLENI
I
N
---
K
---
D
S
S
-----
I
P
Q
K
---
M
Q
N
R
H
I
V
I
R
S
E
H
T
Q
Q
V
L
Q
L
R
S
E
I
Q
W
Y
F
R
K
Y
Y
H
D
N
H
F
T
E
I
Q
P
P
T
I
V
K
------
S
T
L
F
K
L
Q
Y
F
N
E
P
A
Y
L
T
Q
S
S
Q
L
Y
L
E
S
V
-
I
A
S
-
L
G
--
K
S
F
C
M
L
S
S
Y
R
A
E
Q
S
R
T
V
R
H
L
A
E
Y
L
H
L
E
A
E
L
P
F
-
I
-
S
F
E
D
L
L
N
H
L
E
D
L
V
C
T
V
I
D
N
V
M
---
A
V
H
--
G
D
K
I
R
K
M
N
P
H
L
K
L
P
T
R
P
F
K
R
M
T
Y
A
D
A
I
K
Y
C
N
--
D
H
G
I
------
L
N
KD
K
P
-
F
E
Y
G
E
D
I
S
E
K
P
-------------------
E
R
Q
M
T
D
E
---
I
----
G
-
C
P
I
-
F
M
I
H
F
P
S
K
M
K
A
F
Y
M
S
K
V
P
G
H
P
D
L
T
E
S
V
D
L
L
M
P
-
G
V
G
-
E
I
V
G
G
S
M
R
I
W
N
Y
D
E
L
M
G
A
Y
K
A
N
G
L
N
P
D
-----
P
Y
Y
W
Y
T
Q
Q
R
K
Y
G
S
C
P
H
G
G
Y
G
L
G
V
E
R
L
V
M
W
L
L
G
E
D
H
I
R
K
V
C
L
Y
P
R
Y
L
E
R
C
E
P
28
HHSearch
86.78
35%
-76
- C4 -
1WYD
3
SYDND_SULTO
A:
[4-429]
------------
S
H
F
I
A
D
V
T
P
E
Y
D
G
-
K
E
V
I
W
A
G
W
V
H
L
L
R
D
L
G
-
G
-
K
K
F
I
I
L
R
D
K
T
G
L
G
Q
V
V
V
D
K
N
S
-----
S
A
F
G
I
S
Q
E
L
T
Q
E
S
V
I
Q
V
R
G
I
V
K
A
--
D
K
R
---
A
--------
P
--------
R
G
I
E
L
H
A
E
E
I
T
L
L
S
-------------
K
A
K
A
P
-
L
P
L
-----
D
V
---
S
GKV
K
A
D
-----
I
D
T
R
---
L
R
E
R
V
L
D
L
R
R
Q
E
M
Q
A
V
I
K
I
Q
S
L
A
L
K
A
F
R
E
T
L
Y
K
E
G
F
I
E
I
F
T
P
K
I
I
A
S
A
T
E
G
G
A
Q
L
F
P
V
I
Y
F
G
K
E
A
F
L
A
Q
S
P
Q
L
Y
K
E
L
M
-
A
G
V
-
V
E
--
R
V
F
E
V
A
P
A
W
R
A
E
E
S
D
T
P
F
H
L
A
E
F
I
S
M
D
V
E
M
A
F
-
A
-
D
Y
N
D
V
M
Q
L
L
E
K
I
L
H
N
I
V
K
T
I
K
E
E
G
K
E
E
--
L
K
I
L
N
Y
E
P
P
E
---
V
K
I
P
I
K
R
L
K
Y
T
E
A
I
E
I
L
R
--
S
K
G
Y
------
N
I
------
K
F
G
D
D
I
G
T
P
E
-------------------
L
R
I
L
N
E
E
---
L
----
K
E
D
L
Y
-
F
I
V
D
W
P
S
D
A
R
P
F
Y
T
K
S
K
S
E
-
P
E
L
S
E
S
F
D
L
I
Y
K
-
F
L
--
E
I
V
S
G
S
T
R
N
H
K
R
E
V
L
E
E
A
L
K
K
K
G
L
K
P
E
-----
S
F
E
F
F
L
K
W
F
D
Y
G
M
P
P
H
A
G
F
G
M
G
L
A
R
L
M
V
M
L
T
G
I
Q
S
V
K
E
I
V
P
F
P
R
D
K
K
R
L
T
P
30
HHSearch
86.54
33%
-86
- C4 -
3M4P
5
?
A:
[29-456]
-----------------------
E
G
-
K
L
V
T
F
K
G
W
A
Y
H
I
R
K
A
R
K
T
-
L
I
F
V
E
L
R
D
G
S
G
Y
C
Q
C
V
I
F
G
K
E
--
L
C
--
E
P
E
K
V
K
L
L
T
R
E
C
S
L
E
I
T
G
R
L
N
A
--
Y
A
G
---
K
NHPPEIAD
I
--------
L
N
L
E
M
Q
V
T
E
W
K
V
I
G
-------------
E
S
P
I
D
-
L
E
N
-----
I
I
N--
K
---
D
S
S
-----
I
P
Q
K
---
M
Q
N
R
H
I
V
I
R
S
E
H
T
Q
Q
V
L
Q
L
R
S
E
I
Q
W
Y
F
R
K
Y
Y
H
D
N
H
F
T
E
I
Q
P
P
T
I
V
K
------
S
T
L
F
K
L
Q
Y
F
N
E
P
A
Y
L
T
Q
S
S
Q
L
Y
L
E
S
V
-
I
A
S
-
L
G
--
K
S
F
C
M
L
S
S
Y
R
A
E
Q
S
R
T
V
R
H
L
A
E
Y
L
H
L
E
A
E
L
P
F
-
I
-
S
F
E
D
L
L
N
H
L
E
D
L
V
C
T
V
I
D
N
V
M
A
V
H
G
D
K
--
I
R
K
M
N
P
H
L
K
L
---
P
T
R
P
F
K
R
M
T
Y
A
D
A
I
K
Y
C
N
--
D
H
G
I
------
L
N
KD
K
P
-
F
E
Y
G
E
D
I
S
E
K
P
-------------------
E
R
Q
M
T
D
E
---
I
----
G
-
C
P
I
-
F
M
I
H
F
P
S
K
M
K
A
F
Y
M
S
K
V
P
G
H
P
D
L
T
E
S
V
D
L
L
M
P
-
G
V
G
-
E
I
V
G
G
S
M
R
I
W
N
Y
D
E
L
M
G
A
Y
K
A
N
G
L
N
P
D
-----
P
Y
Y
W
Y
T
Q
Q
R
K
Y
G
S
C
P
H
G
G
Y
G
L
G
V
E
R
L
V
M
W
L
L
G
E
D
H
I
R
K
V
C
L
Y
P
R
Y
L
E
R
C
E
P
23
PsiBlast_CBE
85.81
35%
-80
- C4 -
1WYD
3
SYDND_SULTO
B:
[16-429]
------------------------
G
-
K
E
V
I
W
A
G
W
V
H
L
L
R
D
L
G
-
G
-
K
K
F
I
I
L
R
D
K
T
G
L
G
Q
V
V
V
D
K
-----
N
S
S
A
F
G
I
S
Q
E
L
T
Q
E
S
V
I
Q
V
R
G
I
V
K
A
--
D
K
R
---
A
--------
P
--------
R
G
I
E
L
H
A
E
E
I
T
L
L
S
-------------
K
A
-
K
A
--
P
L
-----
P
L
---
D
---
V
S
G
KVKAD
I
D
T
R
---
L
R
E
R
V
L
D
L
R
R
Q
E
M
Q
A
V
I
K
I
Q
S
L
A
L
K
A
F
R
E
T
L
Y
K
E
G
F
I
E
I
F
T
P
K
I
I
A
S
A
T
E
G
G
A
Q
L
F
P
V
I
Y
F
G
K
E
A
F
L
A
Q
S
P
Q
L
Y
K
E
L
M
-
A
G
V
-
V
E
--
R
V
F
E
V
A
P
A
W
R
A
E
E
S
D
T
P
F
H
L
A
E
F
I
S
M
D
V
E
M
A
F
-
A
-
D
Y
N
D
V
M
Q
L
L
E
K
I
L
H
N
I
V
K
T
I
K
E
E
G
K
E
E
--
L
K
I
L
N
Y
E
P
P
---
E
V
K
I
P
I
K
R
L
K
Y
T
E
A
I
E
I
L
R
--
S
K
G
Y
-------
N
-----
I
K
F
G
D
D
I
G
T
P
--------------------
E
L
R
I
L
N
E
E
L
K
E
----
D
-
L
-
Y
-
F
I
V
D
W
P
S
D
A
R
P
F
Y
T
K
S
K
S
E
N
P
E
L
S
E
S
F
D
L
I
Y
--
K
F
L
-
E
I
V
S
G
S
T
R
N
H
K
R
E
V
L
E
E
A
L
K
K
K
G
L
K
P
E
-----
S
F
E
F
F
L
K
W
F
D
Y
G
M
P
P
H
A
G
F
G
M
G
L
A
R
L
M
V
M
L
T
G
I
Q
S
V
K
E
I
V
P
F
P
R
D
K
K
R
L
T
P
25
PsiBlast_CBE
85.41
32%
-82
- C4 -
3M4P
5
?
C:
[20-456]
-------------
C
N
I
R
D
A
A
G
L
-
E
G
-
K
L
V
T
F
K
G
W
A
Y
H
I
R
K
A
R
-
K
T
L
I
F
V
E
L
R
D
G
S
G
Y
C
Q
C
V
I
F
G
K
E
--
L
C
E
P
--
E
K
V
K
L
L
T
R
E
C
S
L
E
I
T
G
R
L
N
A
--
Y
A
G
---
K
--------
N
HPPEIADI
L
N
L
E
M
Q
V
T
E
W
K
V
I
G
-------------
E
S
-----
P
I
DLENI
I
N
---
K
---
D
S
S
-----
I
P
Q
K
---
M
Q
N
R
H
I
V
I
R
S
E
H
T
Q
Q
V
L
Q
L
R
S
E
I
Q
W
Y
F
R
K
Y
Y
H
D
N
H
F
T
E
I
Q
P
P
T
I
V
K
-------
T
L
F
K
L
Q
Y
F
N
E
P
A
Y
L
T
Q
S
S
Q
L
Y
L
E
S
V
-
I
A
S
-
L
G
--
K
S
F
C
M
L
S
S
Y
R
A
E
Q
S
R
T
V
R
H
L
A
E
Y
L
H
L
E
A
E
L
P
F
-
I
-
S
F
E
D
L
L
N
H
L
E
D
L
V
C
T
V
I
D
N
V
M
---
A
V
H
--
G
D
K
I
R
K
M
N
P
H
L
K
L
P
T
R
P
F
K
R
M
T
Y
A
D
A
I
K
Y
C
N
--
D
H
----------DKP--
F
E
Y
G
E
D
I
S
E
K
P
-------------------
E
R
Q
M
T
D
E
---
I
----
G
-
C
P
I
-
F
M
I
H
F
P
S
K
M
K
A
F
Y
M
S
K
V
P
G
H
P
D
L
T
E
S
V
D
L
L
M
P
-
G
V
G
-
E
I
V
G
G
S
M
R
I
W
N
Y
D
E
L
M
G
A
Y
K
A
N
G
L
N
P
D
-----
P
Y
Y
W
Y
T
Q
Q
R
K
Y
G
S
C
P
H
G
G
Y
G
L
G
V
E
R
L
V
M
W
L
L
G
E
D
H
I
R
K
V
C
L
Y
P
R
Y
L
E
R
C
E
P
12
PsiBlast_PDB
84.99
32%
-80
- C4 -
2XTI
4
?
A:
[5-437]
---------------
I
R
D
L
V
K
H
-
R
N
-
E
R
V
C
I
K
G
W
I
H
R
M
R
R
Q
G
-
K
S
L
M
F
F
I
L
R
D
G
T
G
F
L
Q
-
V
L
L
M
D
K
--
L
C
Q
T
Y
D
A
L
T
--
V
N
T
E
C
T
V
E
I
Y
G
A
I
K
E
V---
E
---
A
--------
P
--------
N
G
H
E
L
I
A
D
F
W
K
I
I
G
-------------
N
A
-
P
P
-
G
G
I
D
N
V
--
L
N
---
E
---
E
A
S
-----
V
D
K
M
---
L
D
N
R
H
L
V
I
R
G
E
N
A
A
A
L
L
R
L
R
A
A
A
T
R
A
M
R
E
H
F
Y
N
A
G
Y
V
E
V
A
P
P
T
L
V
Q
T
Q
V
E
G
G
S
T
L
F
N
L
D
Y
F
G
E
Q
S
F
L
T
Q
S
S
Q
L
Y
L
E
T
C
-
I
P
T
-
L
G
--
D
V
F
C
I
A
Q
S
Y
R
A
E
K
S
R
T
R
R
H
L
A
E
Y
A
H
V
E
A
E
C
P
F
-
I
-
T
L
D
D
L
M
E
K
I
E
E
L
V
C
D
T
V
D
R
L
L
A
D
E
E
A
K
---
K
L
L
E
H
I
N
P
K
F
Q
P
P
E
R
P
F
L
R
M
E
Y
K
D
A
I
K
W
L
Q
--
E
H
N
V
------
E
N
EFGNT
F
T
Y
G
E
D
I
A
E
A
A
-------------------
E
R
F
M
T
D
T
---
I
----
N
-
K
P
I
-
L
L
N
R
F
P
S
E
I
K
A
F
Y
M
Q
R
D
A
K
D
N
T
L
T
E
S
V
D
L
L
M
P
-
G
V
G
-
E
I
V
G
G
S
M
R
I
W
K
F
D
E
L
S
K
A
F
K
N
V
E
I
D
P
K
-----
P
Y
Y
W
Y
L
D
Q
R
L
Y
G
T
C
P
H
G
G
Y
G
L
G
L
E
R
F
I
C
W
L
T
N
T
N
H
I
R
D
V
C
L
Y
P
R
F
V
G
R
C
V
P
8
PsiBlast_PDB
84.95
35%
-78
- C4 -
1WYD
3
SYDND_SULTO
A:
[16-429]
------------------------
G
-
K
E
V
I
W
A
G
W
V
H
L
L
R
D
L
G
-
G
-
K
K
F
I
I
L
R
D
K
T
G
L
G
Q
V
V
V
D
K
-----
N
S
S
A
F
G
I
S
Q
E
L
T
Q
E
S
V
I
Q
V
R
G
I
V
K
A
--
D
K
R
---
A
--------
P
--------
R
G
I
E
L
H
A
E
E
I
T
L
L
S
-------------
K
A
-
K
A
--
P
L
-----
P
L
---
D
---
V
S
G
KVKAD
I
D
T
R
---
L
R
E
R
V
L
D
L
R
R
Q
E
M
Q
A
V
I
K
I
Q
S
L
A
L
K
A
F
R
E
T
L
Y
K
E
G
F
I
E
I
F
T
P
K
I
I
A
S
A
T
E
G
G
A
Q
L
F
P
V
I
Y
F
G
K
E
A
F
L
A
Q
S
P
Q
L
Y
K
E
L
M
-
A
G
V
-
V
E
--
R
V
F
E
V
A
P
A
W
R
A
E
E
S
D
T
P
F
H
L
A
E
F
I
S
M
D
V
E
M
A
F
-
A
-
D
Y
N
D
V
M
Q
L
L
E
K
I
L
H
N
I
V
K
T
I
K
E
E
G
K
E
E
--
L
K
I
L
N
Y
E
P
P
---
E
V
K
I
P
I
K
R
L
K
Y
T
E
A
I
E
I
L
R
--
S
K
G
Y
-------
N
-----
I
K
F
G
D
D
I
G
T
P
--------------------
E
L
R
I
L
N
E
E
L
K
E
----
D
-
L
-
Y
-
F
I
V
D
W
P
S
D
A
R
P
F
Y
T
K
S
K
S
E
-
P
E
L
S
E
S
F
D
L
I
Y
--
K
F
L
-
E
I
V
S
G
S
T
R
N
H
K
R
E
V
L
E
E
A
L
K
K
K
G
L
K
P
E
-----
S
F
E
F
F
L
K
W
F
D
Y
G
M
P
P
H
A
G
F
G
M
G
L
A
R
L
M
V
M
L
T
G
I
Q
S
V
K
E
I
V
P
F
P
R
D
K
K
R
L
T
P
11
PsiBlast_PDB
84.75
32%
-82
- C4 -
2XGT
3
?
A:
[3-435]
---------------
I
R
D
L
V
K
H
-
R
N
-
E
R
V
C
I
K
G
W
I
H
R
M
R
R
Q
G
-
K
S
L
M
F
F
I
L
R
D
G
T
G
F
L
Q
-
V
L
L
M
D
K
--
L
C
Q
T
Y
D
A
L
T
--
V
N
T
E
C
T
V
E
I
Y
G
A
I
K
E
VP------------------------
N
G
H
E
L
I
A
D
F
W
K
I
I
G
-------------
N
A
-
P
P
-
G
G
I
D
N
V
--
L
N
--------
A
S
-----
V
D
K
M
---
L
D
N
R
H
L
V
I
R
G
E
N
A
A
A
L
L
R
L
R
A
A
A
T
R
A
M
R
E
H
F
Y
N
A
G
Y
V
E
V
A
P
P
T
L
V
Q
T
Q
V
E
G
G
S
T
L
F
N
L
D
Y
F
G
E
Q
S
F
L
T
Q
S
S
Q
L
Y
L
E
T
C
-
I
P
T
-
L
G
--
D
V
F
C
I
A
Q
S
Y
R
A
E
K
S
R
T
R
R
H
L
A
E
Y
A
H
V
E
A
E
C
P
F
-
I
-
T
L
D
D
L
M
E
K
I
E
E
L
V
C
D
T
V
D
R
L
L
A
D
E
E
A
K
---
K
L
L
E
H
I
N
P
K
F
Q
P
P
E
R
P
F
L
R
M
E
Y
K
D
A
I
K
W
L
Q
--
E
H
N
V
------
E
N
EFGNT
F
T
Y
G
E
D
I
A
E
A
A
-------------------
E
R
F
M
T
D
T
---
I
----
N
-
K
P
I
-
L
L
N
R
F
P
S
E
I
K
A
F
Y
M
Q
R
D
A
Q
D
N
T
L
T
E
S
V
D
L
L
M
P
-
G
V
G
-
E
I
V
G
G
S
M
R
I
W
K
F
D
E
L
S
K
A
F
K
N
V
E
I
D
P
K
-----
P
Y
Y
W
Y
L
D
Q
R
L
Y
G
T
C
P
H
G
G
Y
G
L
G
L
E
R
F
I
C
W
L
T
N
T
N
H
I
R
D
V
C
L
Y
P
R
F
V
G
R
C
V
P
27
PsiBlast_CBE
84.46
32%
-80
- C4 -
2XTI
4
?
B:
[5-437]
---------------
I
R
D
L
V
K
H
-
R
N
-
E
R
V
C
I
K
G
W
I
H
R
M
R
R
Q
G
-
K
S
L
M
F
F
I
L
R
D
G
T
G
F
L
Q
-
V
L
L
M
D
K
--
L
C
Q
T
Y
D
A
L
T
--
V
N
T
E
C
T
V
E
I
Y
G
A
I
K
E
V
P------
A
--------
P
--------
N
G
H
E
L
I
A
D
F
W
K
I
I
G
-------------
N
A
-
P
P
-
G
G
I
D
N
V
--
L
N
---
E
---
E
A
S
-----
V
D
K
M
---
L
D
N
R
H
L
V
I
R
G
E
N
A
A
A
L
L
R
L
R
A
A
A
T
R
A
M
R
E
H
F
Y
N
A
G
Y
V
E
V
A
P
P
T
L
V
Q
T
Q
V
---
S
T
L
F
N
L
D
Y
F
G
E
Q
S
F
L
T
Q
S
S
Q
L
Y
L
E
T
C
-
I
P
T
-
L
G
--
D
V
F
C
I
A
Q
S
Y
R
A
E
K
S
R
T
R
R
H
L
A
E
Y
A
H
V
E
A
E
C
P
F
-
I
-
T
L
D
D
L
M
E
K
I
E
E
L
V
C
D
T
V
D
R
L
L
A
D
E
E
A
K
---
K
L
L
E
H
I
N
P
K
F
Q
P
P
E
R
P
F
L
R
M
E
Y
K
D
A
I
K
W
L
Q
--
E
H
N
V
------
E
N
EFGNT
F
T
Y
G
E
D
I
A
E
A
A
-------------------
E
R
F
M
T
D
T
---
I
----
N
-
K
P
I
-
L
L
N
R
F
P
S
E
I
K
A
F
Y
M
Q
R
D
A
K
D
N
T
L
T
E
S
V
D
L
L
M
P
-
G
V
G
-
E
I
V
G
G
S
M
R
I
W
K
F
D
E
L
S
K
A
F
K
N
V
E
I
D
P
K
-----
P
Y
Y
W
Y
L
D
Q
R
L
Y
G
T
C
P
H
G
G
Y
G
L
G
L
E
R
F
I
C
W
L
T
N
T
N
H
I
R
D
V
C
L
Y
P
R
F
V
G
R
C
V
P
36
HHSearch
84.35
33%
-76
- C4 -
2XGT
3
?
A:
[3-435]
---------------
I
R
D
L
V
K
H
-
R
N
-
E
R
V
C
I
K
G
W
I
H
R
M
R
R
Q
G
K
S
-
L
M
F
F
I
L
R
D
G
T
G
F
L
Q
V
L
L
M
D
K
L
--
C
--
Q
T
Y
D
-
A
L
T
V
N
T
E
C
T
V
E
I
Y
G
A
I
K
E
--
V
P
----------------------
N
G
H
E
L
I
A
D
F
W
K
I
I
G
-------------
N
A
-
P
P
-
G
G
I
-----
D
N
V
L
N-----
A
S
-----
V
D
K
M
---
L
D
N
R
H
L
V
I
R
G
E
N
A
A
A
L
L
R
L
R
A
A
A
T
R
A
M
R
E
H
F
Y
N
A
G
Y
V
E
V
A
P
P
T
L
V
Q
T
Q
V
E
G
G
S
T
L
F
N
L
D
Y
F
G
E
Q
S
F
L
T
Q
S
S
Q
L
Y
L
E
T
C
-
I
P
T
-
L
G
--
D
V
F
C
I
A
Q
S
Y
R
A
E
K
S
R
T
R
R
H
L
A
E
Y
A
H
V
E
A
E
C
P
F
-
I
-
T
L
D
D
L
M
E
K
I
E
E
L
V
C
D
T
V
D
R
L
L
A
D
E
E
A
K
K
L
L
E
H
I
N
P
K
F
Q
P
---
P
E
R
P
F
L
R
M
E
Y
K
D
A
I
K
W
L
Q
--
E
H
N
V
ENEFGN
T
F
------
T
Y
G
E
D
I
A
E
A
A
-------------------
E
R
F
M
T
D
T
---
I
----
N
-
K
P
I
-
L
L
N
R
F
P
S
E
I
K
A
F
Y
M
Q
R
D
A
Q
D
N
T
L
T
E
S
V
D
L
L
M
P
-
G
V
G
-
E
I
V
G
G
S
M
R
I
W
K
F
D
E
L
S
K
A
F
K
N
V
E
I
D
P
K
-----
P
Y
Y
W
Y
L
D
Q
R
L
Y
G
T
C
P
H
G
G
Y
G
L
G
L
E
R
F
I
C
W
L
T
N
T
N
H
I
R
D
V
C
L
Y
P
R
F
V
G
R
C
V
P
48
Fugue
83.49
35%
-78
- C4 -
1B8A
4
SYD_THEKO
A:
[1-438]
MYRTHYSSEIT-----
E
-
E
L
N
G
----
Q
K
V
K
V
A
G
W
V
W
E
V
K
D
L
G
-
G
-
I
K
F
L
W
I
R
D
R
D
G
I
V
Q
I
T
A
P
K
--KK
V
D
P
E
L
F
K
L
I
P
K
L
R
S
E
D
V
V
A
V
E
G
V
V
N
F
--
T
P
-KAK------------------
L
G
F
E
I
L
P
E
K
I
V
V
L
N
R
A
E
T
PLPLDPTGK-------------------
V
---
K
A
E
-----
L
D
T
R
---
L
N
N
R
F
M
D
L
R
R
P
E
V
M
A
I
F
K
I
R
S
S
V
F
K
A
V
R
D
F
F
H
E
N
G
F
I
E
I
H
T
P
K
I
I
A
T
A
T
E
G
G
T
E
L
F
P
M
K
Y
F
E
E
D
A
F
L
A
E
S
P
Q
L
Y
K
E
I
M
-
M
A
S
G
L
D
--
R
V
Y
E
I
A
P
I
F
R
A
E
E
H
N
T
T
R
H
L
N
E
A
W
S
I
D
S
E
M
A
F
I
E
-
D
E
E
E
V
M
S
F
L
E
R
L
V
A
H
A
I
N
Y
V
R
E
H
N
A
K
E
--
L
D
I
L
N
--
F
E
L
E
E
P
K
L
-
P
F
P
R
V
S
Y
D
K
A
L
E
I
L
G
D
L
----------------------------G
K
E
I
P
WGEDID
T
E
G
E
R
L
L
G
K
Y
M
M
E
N
E
---
N
----
A
-
P
L
Y
-
F
L
Y
Q
Y
P
S
E
A
K
P
F
Y
I
M
K
Y
D
N
K
P
E
I
C
R
A
F
D
L
E
Y
--
R
G
V
-
E
I
S
S
G
G
Q
R
E
H
R
H
D
I
L
V
E
Q
I
K
E
K
-----GLNPE
S
F
E
F
Y
L
K
A
F
R
Y
G
M
P
P
H
G
G
F
G
L
G
A
E
R
L
I
K
Q
M
L
D
L
P
N
I
R
E
V
I
L
F
P
R
D
R
R
R
L
T
P