@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : SA2416: (2016-04-04 )
MLLEVKHVKKVYGKGLNATTALNQMNLSVGAGEFVAIMGESGSGKSTLLNLIASFDGLTEGDIIVDGAHLNNMKNKSKALYRQQMVGFVFQDFNLLPTMTNKENIMMPLILAGAKRKDIEQRVHQLAVQLHLEGFLNKYPSEISGGQKQRIAIARALVTKPTILLADEPTGALDSKTSKALMMLFQEIHQLEQTILMVTHSNIDASYAERVIFIKDGRLYHEIYRGEESQLAFQQRITDSLALVNGGSVNI
Atome Classification :
(41 SA)
.........10......-..20........30........40........50........60........70......---..80.-...------....90--........100------....-.-..110----.------...---.....120.......130-..-..-...140----------........150.......160.......170.......180.......-190.-.--..-....200...-...-..210.......-----220----.-------.......230.......240.......250
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MLL
E
V
K
H
V
K
K
V
Y
GKGLN-A
T
T
A
L
N
Q
M
N
L
SVGA
G
E
F
V
A
I
MGESGS
G
K
S
T
L
L
N
L
I
A
S
FDGLTEG
D
I
I
V
DGAHLNNM
K
N
K
S
---
K
A
L
Y
R
-
Q
Q
M
------
V
G
F
V
F
Q
--DFNLLPTMTNK------EN
I
M
-
M
-
P
L
I
------L------AGA---K
R
K
D
I
E
Q
R
V
H
Q
L
A
V
Q
L
H
L
-
E
G
-
F
L
-
N
KY
P
S
-----------EISGGQ
K
Q
R
I
A
I
A
R
A
LVTK
P
T
I
L
L
ADEPTGALD
S
K
T
S
K
A
L
M
M
L
F
Q
E
I
H
-
Q
-
L
E
-
Q
--
T
I
-
L
M
V
THS-NI
D
-
A
S
Y
-A
E
R
V
I
F
IKDG
R
L
-----
Y
H
-----
E
-------
I
YRG
E
E
S
Q
L
A
F
Q
Q
RI
T
D
S
L
A
L
VNGGSVNI
9
PsiBlast_PDB
89.55
34%
-114
- C1 -
3TUZ
1
METN_ECOLI
C:
[24-270]
-
M
I
K
L
S
N
I
T
K
V
F
H
Q
G
T
R
-
T
I
Q
A
L
N
N
V
S
L
H
V
P
A
G
Q
I
Y
G
V
I
G
A
S
G
A
G
K
S
T
L
I
R
C
V
N
L
L
E
R
P
T
E
G
S
V
L
V
D
G
Q
E
L
T
T
L
S
E
S
E
---
L
T
K
A
R
-
R
Q
-------
I
G
M
I
F
Q
--
H
F
N
L
L
S
S
R
T
V
F
------
G
N
V
A
-
L
-
P
L
E
------
L
------
D
N
T
---
P
K
D
E
V
K
R
R
V
T
E
L
L
S
L
V
G
L
-
G
D
-
K
H
-
D
S
Y
P
S
-----------
N
L
S
G
G
Q
K
Q
R
V
A
I
A
R
A
L
A
S
N
P
K
V
L
L
C
D
Q
A
T
S
A
L
D
P
A
T
T
R
S
I
L
E
L
L
K
D
I
N
R
R
-
L
G
-
L
--
T
I
-
L
L
I
T
H
E
M
D
V
V
-
K
R
I
-
C
D
C
V
A
V
I
S
N
G
E
L
-----
I
E
QDTVS
E
-------
V
F
S
H
P
K
T
P
L
A
-
Q
K
F
I
Q
S
T
L
H
L
--------
26
PsiBlast_CBE
87.78
34%
-106
- C1 -
3TUZ
1
METN_ECOLI
G:
[24-270]
-
M
I
K
L
S
N
I
T
K
V
F
H
Q
G
T
R
-
T
I
Q
A
L
N
N
V
S
L
H
V
P
A
G
Q
I
Y
G
V
I
G
A
S
G
A
G
K
S
T
L
I
R
C
V
N
L
L
E
R
P
T
E
G
S
V
L
V
D
G
Q
E
L
T
T
L
S
E
S
E
---
L
T
K
A
R
-
R
Q
-------
I
G
M
I
F
Q
--
H
F
N
L
L
S
S
R
T
V
F
------
G
N
V
A
-
L
-
P
L
E
------
L
------
D
N
T
---
P
K
D
E
V
K
R
R
V
T
E
L
L
S
L
V
G
L
-
G
D
-
K
H
-
D
S
Y
P
S
-----------
N
L
S
G
G
Q
K
Q
R
V
A
I
A
R
A
L
A
S
N
P
K
V
L
L
C
D
Q
A
T
S
A
L
D
P
A
T
T
R
S
I
L
E
L
L
K
D
I
N
R
R
-
L
G
-
L
--
T
I
-
L
L
I
T
H
E
M
D
V
V
-
K
R
I
-
C
D
C
V
A
V
I
S
N
G
E
L
-----
I
E
QDTVS
E
-------
V
F
S
H
P
K
T
P
L
A
-
Q
K
F
I
Q
S
T
L
H
L
--------
29
PsiBlast_CBE
87.69
34%
-107
- C1 -
3TUI
1
METN_ECOLI
G:
[24-270]
-
M
I
K
L
S
N
I
T
K
V
F
H
Q
G
T
R
-
T
I
Q
A
L
N
N
V
S
L
H
V
P
A
G
Q
I
Y
G
V
I
G
A
S
G
A
G
K
S
T
L
I
R
C
V
N
L
L
E
R
P
T
E
G
S
V
L
V
D
G
Q
E
L
T
T
L
S
E
S
E
---
L
T
K
A
R
-
R
Q
-------
I
G
M
I
F
Q
--
H
F
N
L
L
S
S
R
T
V
F
------
G
N
V
A
-
L
-
P
L
E
------
L
------
D
N
T
---
P
K
D
E
V
K
R
R
V
T
E
L
L
S
L
V
G
L
-
G
D
-
K
H
-
D
S
Y
P
S
-----------
N
L
S
G
G
Q
K
Q
R
V
A
I
A
R
A
L
A
S
N
P
K
V
L
L
C
D
Q
A
T
S
A
L
D
P
A
T
T
R
S
I
L
E
L
L
K
D
I
N
R
R
-
L
G
-
L
--
T
I
-
L
L
I
T
H
E
M
D
V
V
-
K
R
I
-
C
D
C
V
A
V
I
S
N
G
E
L
-----
I
E
QDTVS
E
-------
V
F
S
H
P
K
T
P
L
A
-
Q
K
F
I
Q
S
T
L
H
L
--------
30
PsiBlast_CBE
87.60
34%
-112
- C1 -
3TUI
1
METN_ECOLI
D:
[24-270]
-
M
I
K
L
S
N
I
T
K
V
F
H
Q
G
T
R
-
T
I
Q
A
L
N
N
V
S
L
H
V
P
A
G
Q
I
Y
G
V
I
G
A
S
G
A
G
K
S
T
L
I
R
C
V
N
L
L
E
R
P
T
E
G
S
V
L
V
D
G
Q
E
L
T
T
L
S
E
S
E
---
L
T
K
A
R
-
R
Q
-------
I
G
M
I
F
Q
--
H
F
N
L
L
S
S
R
T
V
F
------
G
N
V
A
-
L
-
P
L
E
------
L
------
D
N
T
---
P
K
D
E
V
K
R
R
V
T
E
L
L
S
L
V
G
L
-
G
D
-
K
H
-
D
S
Y
P
S
-----------
N
L
S
G
G
Q
K
Q
R
V
A
I
A
R
A
L
A
S
N
P
K
V
L
L
C
D
Q
A
T
S
A
L
D
P
A
T
T
R
S
I
L
E
L
L
K
D
I
N
R
R
-
L
G
-
L
--
T
I
-
L
L
I
T
H
E
M
D
V
V
-
K
R
I
-
C
D
C
V
A
V
I
S
N
G
E
L
-----
I
E
QDTVS
E
-------
V
F
S
H
P
K
T
P
L
A
-
Q
K
F
I
Q
S
T
L
H
L
--------
28
PsiBlast_CBE
86.79
34%
-114
- C1 -
3TUI
1
METN_ECOLI
H:
[24-270]
-
M
I
K
L
S
N
I
T
K
V
F
H
Q
G
T
R
-
T
I
Q
A
L
N
N
V
S
L
H
V
P
A
G
Q
I
Y
G
V
I
G
A
S
G
A
G
K
S
T
L
I
R
C
V
N
L
L
E
R
P
T
E
G
S
V
L
V
D
G
Q
E
L
T
T
L
S
E
S
E
---
L
T
K
A
R
-
R
Q
-------
I
G
M
I
F
Q
--
H
F
N
L
L
S
S
R
T
V
F
------
G
N
V
A
-
L
-
P
L
E
------
L
------
D
N
T
---
P
K
D
E
V
K
R
R
V
T
E
L
L
S
L
V
G
L
-
G
D
-
K
H
-
D
S
Y
P
S
-----------
N
L
S
G
G
Q
K
Q
R
V
A
I
A
R
A
L
A
S
N
P
K
V
L
L
C
D
Q
A
T
S
A
L
D
P
A
T
T
R
S
I
L
E
L
L
K
D
I
N
R
R
-
L
G
-
L
--
T
I
-
L
L
I
T
H
E
M
D
V
V
-
K
R
I
-
C
D
C
V
A
V
I
S
N
G
E
L
-----
I
E
QDTVS
E
-------
V
F
S
H
P
K
T
P
L
A
-
Q
K
F
I
Q
S
T
L
H
L
--------
8
PsiBlast_PDB
86.68
34%
-111
- C1 -
3TUI
1
METN_ECOLI
C:
[24-270]
-
M
I
K
L
S
N
I
T
K
V
F
H
Q
G
T
R
-
T
I
Q
A
L
N
N
V
S
L
H
V
P
A
G
Q
I
Y
G
V
I
G
A
S
G
A
G
K
S
T
L
I
R
C
V
N
L
L
E
R
P
T
E
G
S
V
L
V
D
G
Q
E
L
T
T
L
S
E
S
E
---
L
T
K
A
R
-
R
Q
-------
I
G
M
I
F
Q
--
H
F
N
L
L
S
S
R
T
V
F
------
G
N
V
A
-
L
-
P
L
E
------
L
------
D
N
T
---
P
K
D
E
V
K
R
R
V
T
E
L
L
S
L
V
G
L
-
G
D
-
K
H
-
D
S
Y
P
S
-----------
N
L
S
G
G
Q
K
Q
R
V
A
I
A
R
A
L
A
S
N
P
K
V
L
L
C
D
Q
A
T
S
A
L
D
P
A
T
T
R
S
I
L
E
L
L
K
D
I
N
R
R
-
L
G
-
L
--
T
I
-
L
L
I
T
H
E
M
D
V
V
-
K
R
I
-
C
D
C
V
A
V
I
S
N
G
E
L
-----
I
E
QDTVS
E
-------
V
F
S
H
P
K
T
P
L
A
-
Q
K
F
I
Q
S
T
L
H
L
--------
122
HHSearch
84.02
41%
-110
- C1 -
3TIF
7
Y796_METJA
A:
[1-230]
-
M
V
K
L
K
N
V
T
K
T
Y
K
M
G
E
E
-
I
I
Y
A
L
K
N
V
N
L
N
I
K
E
G
E
F
V
S
I
M
G
P
S
G
S
G
K
S
T
M
L
N
I
I
G
C
L
D
K
P
T
E
G
E
V
Y
I
D
N
I
K
T
N
D
L
D
D
D
E
---
L
T
K
I
R
-
R
D
K
------
I
G
F
V
F
Q
--
Q
F
N
L
I
P
L
L
T
A
L
------
E
N
V
E
-
L
-
P
L
I
------
F
------
K
Y
R
G
A
M
S
G
E
E
R
R
K
R
A
L
E
C
L
K
M
A
E
L
-
E
E
R
F
A
-
N
H
K
P
N
-----------
Q
L
S
G
G
Q
Q
Q
R
V
A
I
A
R
A
L
A
N
N
P
P
I
I
L
A
D
Q
P
T
W
A
L
D
S
K
T
G
E
K
I
M
Q
L
L
K
K
L
N
-
E
E
D
G
-
K
--
T
V
-
V
V
V
T
H
D
-
I
N
V
-
A
R
F
-
G
E
R
I
I
Y
L
K
D
G
E
V
-----
E
R
-----
E
-------
E
K
L
R
-------------------------
27
PsiBlast_CBE
83.31
34%
-111
- C1 -
3TUZ
1
METN_ECOLI
D:
[24-270]
-
M
I
K
L
S
N
I
T
K
V
F
H
Q
G
T
R
-
T
I
Q
A
L
N
N
V
S
L
H
V
P
A
G
Q
I
Y
G
V
I
G
A
S
G
A
G
K
S
T
L
I
R
C
V
N
L
L
E
R
P
T
E
G
S
V
L
V
D
G
Q
E
L
T
T
L
S
E
S
E
---
L
T
K
A
R
-
R
Q
-------
I
G
M
I
F
Q
--
H
F
N
L
L
S
S
R
T
V
F
------
G
N
V
A
-
L
-
P
L
E
------
L
------
D
N
T
---
P
K
D
E
V
K
R
R
V
T
E
L
L
S
L
V
G
L
-
G
D
-
K
H
-
D
S
Y
P
S
-----------
N
L
S
G
G
Q
K
Q
R
V
A
I
A
R
A
L
A
S
N
P
K
V
L
L
C
D
Q
A
T
S
A
L
D
P
A
T
T
R
S
I
L
E
L
L
K
D
I
N
R
R
-
L
G
-
L
--
T
I
-
L
L
I
T
H
E
M
D
V
V
-
K
R
I
-
C
D
C
V
A
V
I
S
N
G
E
L
-----
I
E
QDTVS
E
-------
V
F
S
H
P
K
T
P
L
A
-
Q
K
F
I
Q
S
T
L
H
L
--------
5
PsiBlast_PDB
83.16
40%
-112
- C1 -
2PCL
12
LOLD_AQUAE
A:
[4-223]
-
I
L
R
A
E
N
I
K
K
V
----
I
R
-
G
Y
E
I
L
K
G
I
S
L
S
V
K
K
G
E
F
V
S
I
I
G
A
S
G
S
G
K
S
T
L
L
Y
I
L
G
L
L
D
A
P
T
E
G
K
V
F
L
E
G
K
E
V
D
Y
T
N
E
K
E
---
L
S
L
L
R
-
N
R
K
------
L
G
F
V
F
Q
--
F
H
Y
L
I
P
E
L
T
A
L
------
E
N
V
I
-
V
-
P
M
L
------
K
------
M
G
K
---
P
K
K
E
A
K
E
R
G
E
Y
L
L
S
E
L
G
L
-
G
D
-
K
L
-
S
R
K
P
Y
-----------
E
L
S
G
G
E
Q
Q
R
V
A
I
A
R
A
L
A
N
E
P
I
L
L
F
A
D
E
P
T
G
N
L
D
S
A
N
T
K
R
V
M
D
I
F
L
K
I
N
-
E
-
G
G
-
T
--
S
I
-
V
M
V
T
H
E
-
R
E
L
-
A
E
L
-
T
H
R
T
L
E
M
K
D
G
K
V
-----
V
G
-----
E
-------
I
T
R
--------------------------
25
PsiBlast_CBE
82.83
34%
-114
- C1 -
3TUZ
1
METN_ECOLI
H:
[24-270]
-
M
I
K
L
S
N
I
T
K
V
F
H
Q
G
T
R
-
T
I
Q
A
L
N
N
V
S
L
H
V
P
A
G
Q
I
Y
G
V
I
G
A
S
G
A
G
K
S
T
L
I
R
C
V
N
L
L
E
R
P
T
E
G
S
V
L
V
D
G
Q
E
L
T
T
L
S
E
S
E
---
L
T
K
A
R
-
R
Q
-------
I
G
M
I
F
Q
--
H
F
N
L
L
S
S
R
T
V
F
------
G
N
V
A
-
L
-
P
L
E
------
L
------
D
N
T
---
P
K
D
E
V
K
R
R
V
T
E
L
L
S
L
V
G
L
-
G
D
-
K
H
-
D
S
Y
P
S
-----------
N
L
S
G
G
Q
K
Q
R
V
A
I
A
R
A
L
A
S
N
P
K
V
L
L
C
D
Q
A
T
S
A
L
D
P
A
T
T
R
S
I
L
E
L
L
K
D
I
N
R
R
-
L
G
-
L
--
T
I
-
L
L
I
T
H
E
M
D
V
V
-
K
R
I
-
C
D
C
V
A
V
I
S
N
G
E
L
-----
I
E
QDTVS
E
-------
V
F
S
H
P
K
T
P
L
A
-
Q
K
F
I
Q
S
T
L
H
L
--------
3
PsiBlast_PDB
82.71
41%
-99
- C1 -
1F3O
2
Y796_METJA
A:
[2-226]
--
I
K
L
K
N
V
T
K
T
Y
K
M
G
E
E
-
I
I
Y
A
L
K
N
V
N
L
N
I
K
E
G
E
F
V
S
I
M
G
P
S
G
S
G
K
S
T
M
L
N
I
I
G
C
L
D
K
P
T
E
G
E
V
Y
I
D
N
I
K
T
N
D
L
D
D
D
E
---
L
T
K
I
R
-
R
D
K
------
I
G
F
V
F
Q
--
Q
F
N
L
I
P
L
L
T
A
L
------
E
N
V
E
-
L
-
P
L
I
------
F
K
YRGAM
S
G
E
---
E
R
R
---
K
R
A
L
E
C
L
K
M
A
E
L
-
E
E
R
F
A
-
N
H
K
P
N
-----------
Q
L
S
G
G
Q
Q
Q
R
V
A
I
A
R
A
L
A
N
N
P
P
I
I
L
A
D
E
P
T
G
A
L
D
S
K
T
G
E
K
I
M
Q
L
L
K
K
L
N
-
E
-
E
D
G
K
--
T
V
-
V
V
V
T
H
D
-
I
N
V
-
A
R
F
-
G
E
R
I
I
Y
L
K
D
G
E
V
-----
E
R
-----
E
------------------------------------
117
HHSearch
82.37
41%
-111
- C1 -
2PCJ
-
LOLD_AQUAE
A:
[3-223]
E
I
L
R
A
E
N
I
K
K
V
I
R
-----
G
Y
E
I
L
K
G
I
S
L
S
V
K
K
G
E
F
V
S
I
I
G
A
S
G
S
G
K
S
T
L
L
Y
I
L
G
L
L
D
A
P
T
E
G
K
V
F
L
E
G
K
E
V
D
Y
T
N
E
K
E
---
L
S
L
L
R
-
N
R
K
------
L
G
F
V
F
Q
--
F
H
Y
L
I
P
E
L
T
A
L
------
E
N
V
I
-
V
-
P
M
L
------
K
------
M
G
K
---
P
K
K
E
A
K
E
R
G
E
Y
L
L
S
E
L
G
L
-
G
D
-
K
L
-
S
R
K
P
Y
-----------
E
L
S
G
G
E
Q
Q
R
V
A
I
A
R
A
L
A
N
E
P
I
L
L
F
A
D
E
P
T
G
N
L
D
S
A
N
T
K
R
V
M
D
I
F
L
K
I
N
-
E
-
G
G
-
T
--
S
I
-
V
M
V
T
H
E
-
R
E
L
-
A
E
L
-
T
H
R
T
L
E
M
K
D
G
K
V
-----
V
G
-----
E
-------
I
T
R
--------------------------
23
PsiBlast_CBE
82.08
40%
-111
- C1 -
2PCJ
1
LOLD_AQUAE
B:
[4-223]
-
I
L
R
A
E
N
I
K
K
V
----
I
R
-
G
Y
E
I
L
K
G
I
S
L
S
V
K
K
G
E
F
V
S
I
I
G
A
S
G
S
G
K
S
T
L
L
Y
I
L
G
L
L
D
A
P
T
E
G
K
V
F
L
E
G
K
E
V
D
Y
T
N
E
K
E
---
L
S
L
L
R
-
N
R
K
------
L
G
F
V
F
Q
--
F
H
Y
L
I
P
E
L
T
A
L
------
E
N
V
I
-
V
-
P
M
L
------
K
------
M
G
K
---
P
K
K
E
A
K
E
R
G
E
Y
L
L
S
E
L
G
L
-
G
D
-
K
L
-
S
R
K
P
Y
-----------
E
L
S
G
G
E
Q
Q
R
V
A
I
A
R
A
L
A
N
E
P
I
L
L
F
A
D
E
P
T
G
N
L
D
S
A
N
T
K
R
V
M
D
I
F
L
K
I
N
-
E
-
G
G
-
T
--
S
I
-
V
M
V
T
H
E
-
R
E
L
-
A
E
L
-
T
H
R
T
L
E
M
K
D
G
K
V
-----
V
G
-----
E
-------
I
T
R
--------------------------
22
PsiBlast_CBE
81.52
41%
-99
- C1 -
3TIF
7
Y796_METJA
B:
[1-226]
-
M
V
K
L
K
N
V
T
K
T
Y
K
M
G
E
E
-
I
I
Y
A
L
K
N
V
N
L
N
I
K
E
G
E
F
V
S
I
M
G
P
S
G
S
G
K
S
T
M
L
N
I
I
G
C
L
D
K
P
T
E
G
E
V
Y
I
D
N
I
K
T
N
D
L
D
D
D
E
---
L
T
K
I
R
-
R
D
K
------
I
G
F
V
F
Q
--
Q
F
N
L
I
P
L
L
T
A
L
------
E
N
V
E
-
L
-
P
L
I
FKYRGA
M
------
S
G
E
---
E
R
R
--
K
R
A
L
E
C
L
K
M
A
E
L
E
-
E
R
-
F
A
-
N
H
K
P
N
-----------
Q
L
S
G
G
Q
Q
Q
R
V
A
I
A
R
A
L
A
N
N
P
P
I
I
L
A
D
Q
P
T
W
A
L
D
S
K
T
G
E
K
I
M
Q
L
L
K
K
L
N
-
E
-
E
D
G
K
--
T
V
-
V
V
V
T
H
D
-
I
N
V
-
A
R
F
-
G
E
R
I
I
Y
L
K
D
G
E
V
-----
E
R
-----
E
------------------------------------
1
PsiBlast_PDB
81.36
41%
-98
- C1 -
1L2T
4
Y796_METJA
A:
[1-226]
-
M
I
K
L
K
N
V
T
K
T
Y
K
M
G
E
E
-
I
I
Y
A
L
K
N
V
N
L
N
I
K
E
G
E
F
V
S
I
M
G
P
S
G
S
G
K
S
T
M
L
N
I
I
G
C
L
D
K
P
T
E
G
E
V
Y
I
D
N
I
K
T
N
D
L
D
D
D
E
---
L
T
K
I
R
-
R
D
K
------
I
G
F
V
F
Q
--
Q
F
N
L
I
P
L
L
T
A
L
------
E
N
V
E
-
L
-
P
L
I
FKYR
G
A
M
------
S
G
E
---
E
R
R
--
K
R
A
L
E
C
L
K
M
A
E
L
E
-
E
R
-
F
A
-
N
H
K
P
N
-----------
Q
L
S
G
G
Q
Q
Q
R
V
A
I
A
R
A
L
A
N
N
P
P
I
I
L
A
D
Q
P
T
G
A
L
D
S
K
T
G
E
K
I
M
Q
L
L
K
K
L
N
-
E
-
E
D
G
K
--
T
V
-
V
V
V
T
H
D
-
I
N
V
-
A
R
F
-
G
E
R
I
I
Y
L
K
D
G
E
V
-----
E
R
-----
E
------------------------------------
6
PsiBlast_PDB
81.31
35%
-107
- C1 -
3DHW
-
METN_ECOLI
C:
[1-247]
-
M
I
K
L
S
N
I
T
K
V
F
H
Q
G
T
R
-
T
I
Q
A
L
N
N
V
S
L
H
V
P
A
G
Q
I
Y
G
V
I
G
A
S
G
A
G
K
S
T
L
I
R
C
V
N
L
L
E
R
P
T
E
G
S
V
L
V
D
G
Q
E
L
T
T
L
S
E
S
E
---
L
T
K
A
R
-
R
Q
-------
I
G
M
I
F
Q
--
H
F
N
L
L
S
S
R
T
V
F
------
G
N
V
A
-
L
-
P
L
E
------
L
------
D
N
T
---
P
K
D
E
V
K
R
R
V
T
E
L
L
S
L
V
G
L
-
G
D
-
K
H
-
D
S
Y
P
S
-----------
N
L
S
G
G
Q
K
Q
R
V
A
I
A
R
A
L
A
S
N
P
K
V
L
L
C
D
E
A
T
S
A
L
D
P
A
T
T
R
S
I
L
E
L
L
K
D
I
N
R
R
-
L
G
-
L
--
T
I
-
L
L
I
T
H
E
M
D
V
V
-
K
R
I
-
C
D
C
V
A
V
I
S
N
G
E
L
-----
I
E
QDTVS
E
-------
V
F
S
H
P
K
T
P
L
A
-
Q
K
F
I
Q
S
T
L
H
L
--------
56
PsiBlast_CBE
80.91
33%
-119
- C1 -
4U02
1
?
C:
[4-241]
-
I
I
R
I
R
N
L
H
K
W
F
G
-----
P
L
H
V
L
K
G
I
H
L
E
V
A
P
G
E
K
L
V
I
I
G
P
S
G
S
G
K
S
T
L
I
R
T
I
N
R
L
E
D
F
Q
E
G
E
V
V
V
D
G
L
S
V
K
D
----
D
---
R
A
L
R
E
I
R
R
E
------
V
G
M
V
F
Q
--
Q
F
N
L
F
P
H
M
T
V
L
------
E
N
V
T
-
L
A
P
M
R
------
V
------
R
R
W
---
P
R
E
K
A
E
K
K
A
L
E
L
L
E
R
V
G
I
-
L
D
-
Q
A
-
R
K
Y
P
A
-----------
Q
L
S
G
G
Q
Q
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
D
V
M
R
D
L
A
-
Q
-
G
G
-
M
--
T
M
-
V
V
V
T
H
E
M
G
F
A
-
R
E
V
-
A
D
R
V
V
F
M
D
G
G
Q
I
-----
V
E
-----
E
GRPEEIF
T
R
P
K
E
E
R
T
R
S
F
L
Q
R
V
--------------
2
PsiBlast_PDB
80.57
41%
-98
- C1 -
3TIF
7
Y796_METJA
A:
[1-226]
-
M
V
K
L
K
N
V
T
K
T
Y
K
M
G
E
E
-
I
I
Y
A
L
K
N
V
N
L
N
I
K
E
G
E
F
V
S
I
M
G
P
S
G
S
G
K
S
T
M
L
N
I
I
G
C
L
D
K
P
T
E
G
E
V
Y
I
D
N
I
K
T
N
D
L
D
D
D
E
---
L
T
K
I
R
-
R
D
K
------
I
G
F
V
F
Q
--
Q
F
N
L
I
P
L
L
T
A
L
------
E
N
V
E
-
L
-
P
L
I
FKYR
G
A
M
------
S
G
E
---
E
R
R
--
K
R
A
L
E
C
L
K
M
A
E
L
E
-
E
R
-
F
A
-
N
H
K
P
N
-----------
Q
L
S
G
G
Q
Q
Q
R
V
A
I
A
R
A
L
A
N
N
P
P
I
I
L
A
D
Q
P
T
W
A
L
D
S
K
T
G
E
K
I
M
Q
L
L
K
K
L
N
-
E
-
E
D
G
K
--
T
V
-
V
V
V
T
H
D
-
I
N
V
-
A
R
F
-
G
E
R
I
I
Y
L
K
D
G
E
V
-----
E
R
-----
E
------------------------------------
4
PsiBlast_PDB
80.07
40%
-111
- C1 -
2PCJ
-
LOLD_AQUAE
A:
[4-223]
-
I
L
R
A
E
N
I
K
K
V
----
I
R
-
G
Y
E
I
L
K
G
I
S
L
S
V
K
K
G
E
F
V
S
I
I
G
A
S
G
S
G
K
S
T
L
L
Y
I
L
G
L
L
D
A
P
T
E
G
K
V
F
L
E
G
K
E
V
D
Y
T
N
E
K
E
---
L
S
L
L
R
-
N
R
K
------
L
G
F
V
F
Q
--
F
H
Y
L
I
P
E
L
T
A
L
------
E
N
V
I
-
V
-
P
M
L
------
K
------
M
G
K
---
P
K
K
E
A
K
E
R
G
E
Y
L
L
S
E
L
G
L
-
G
D
-
K
L
-
S
R
K
P
Y
-----------
E
L
S
G
G
E
Q
Q
R
V
A
I
A
R
A
L
A
N
E
P
I
L
L
F
A
D
E
P
T
G
N
L
D
S
A
N
T
K
R
V
M
D
I
F
L
K
I
N
-
E
-
G
G
-
T
--
S
I
-
V
M
V
T
H
E
-
R
E
L
-
A
E
L
-
T
H
R
T
L
E
M
K
D
G
K
V
-----
V
G
-----
E
-------
I
T
R
--------------------------
58
PsiBlast_CBE
79.69
33%
-110
- C1 -
4U02
1
?
A:
[4-241]
-
I
I
R
I
R
N
L
H
K
W
F
G
-----
P
L
H
V
L
K
G
I
H
L
E
V
A
P
G
E
K
L
V
I
I
G
P
S
G
S
G
K
S
T
L
I
R
T
I
N
R
L
E
D
F
Q
E
G
E
V
V
V
D
G
L
S
V
K
D
----
D
---
R
A
L
R
E
I
R
R
E
------
V
G
M
V
F
Q
--
Q
F
N
L
F
P
H
M
T
V
L
------
E
N
V
T
-
L
A
P
M
R
------
V
------
R
R
W
---
P
R
E
K
A
E
K
K
A
L
E
L
L
E
R
V
G
I
-
L
D
-
Q
A
-
R
K
Y
P
A
-----------
Q
L
S
G
G
Q
Q
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
D
V
M
R
D
L
A
-
Q
-
G
G
-
M
--
T
M
-
V
V
V
T
H
E
M
G
F
A
-
R
E
V
-
A
D
R
V
V
F
M
D
G
G
Q
I
-----
V
E
-----
E
GR
P
E
E
I
F
T
R
P
K
E
E
R
T
R
S
F
L
Q
R
V
--------------
89
PsiBlast_CBE
78.49
33%
-103
- C1 -
4MKI
4
ECFA2_CALS4
A:
[5-240]
M
P
I
K
V
E
N
V
S
F
I
Y
N
E
G
T
P
Y
A
T
V
A
L
K
D
I
N
F
S
I
D
D
E
E
F
V
G
I
I
G
H
T
G
S
G
K
S
T
L
I
Q
Q
L
N
G
L
L
K
P
S
K
G
K
I
Y
I
N
G
I
D
I
T
D
K
K
V
S
L
---
K
D
I
R
K
-
Q
--------
V
G
L
V
F
Q
YP
E
Y
Q
L
F
E
E
T
V
F
K
------
D
I
A
F
-
G
-
P
S
N
------
L
-------
G
L
---
S
E
E
E
V
K
E
R
V
Y
E
A
M
E
I
V
G
I
-
S
K
-
E
L
A
D
K
S
P
F
-----------
E
L
S
G
G
Q
K
R
R
V
A
I
A
G
I
L
A
M
R
P
K
I
L
I
L
D
E
P
T
A
G
L
D
P
K
G
K
Q
E
I
L
N
K
I
K
E
I
H
-
D
-
K
Y
-
K
--
M
I
T
I
L
V
S
H
N
-
M
E
D
I
A
R
I
-
A
D
K
I
I
V
M
N
R
G
K
I
E
L
I
G
T
P
R
-----
E
-------
V
F
R
E
A
E
-----------------------
96
PsiBlast_CBE
76.50
34%
-111
- C1 -
1B0U
4
HISP_SALTY
A:
[7-234]
--
L
H
V
I
D
L
H
K
R
Y
G
-----
G
H
E
V
L
K
G
V
S
L
Q
A
R
A
G
D
V
I
S
I
I
G
S
S
G
S
G
K
S
T
F
L
R
C
I
N
F
L
E
K
P
S
E
G
A
I
I
V
N
G
Q
N
I
N
L
V
R
D
K
D
GQL
K
V
A
D
K
-
N
Q
L
R
L
L
R
T
R
L
T
M
V
F
Q
--
H
F
N
L
W
S
H
M
T
V
L
------
E
N
V
M
E
A
-
P
I
Q
------
V
------
L
G
L
---
S
K
H
D
A
R
E
R
A
L
K
Y
L
A
K
V
G
I
D
E
R
-
A
Q
-
G
K
Y
P
V
-----------
H
L
S
G
G
Q
Q
Q
R
V
S
I
A
R
A
L
A
M
E
P
D
V
L
L
F
D
E
P
T
S
A
L
D
P
E
L
V
G
E
V
L
R
I
M
Q
Q
L
A
-
E
-
E
G
-
K
--
T
M
-
V
V
V
T
H
E
-
M
G
F
-
A
R
H
V
S
S
H
V
I
F
L
H
Q
G
K
I
-----
E
E
-----
E
------------------------------------
88
PsiBlast_CBE
75.45
33%
-98
- C1 -
4MKI
4
ECFA2_CALS4
B:
[5-240]
M
P
I
K
V
E
N
V
S
F
I
Y
N
E
G
T
P
Y
A
T
V
A
L
K
D
I
N
F
S
I
D
D
E
E
F
V
G
I
I
G
H
T
G
S
G
K
S
T
L
I
Q
Q
L
N
G
L
L
K
P
S
K
G
K
I
Y
I
N
G
I
D
I
T
D
K
K
V
S
L
---
K
D
I
R
K
-
Q
--------
V
G
L
V
F
Q
YP
E
Y
Q
L
F
E
E
T
V
F
K
------
D
I
A
F
-
G
-
P
S
N
------
L
-------
G
L
---
S
E
E
E
V
K
E
R
V
Y
E
A
M
E
I
V
G
I
-
S
K
-
E
L
A
D
K
S
P
F
-----------
E
L
S
G
G
Q
K
R
R
V
A
I
A
G
I
L
A
M
R
P
K
I
L
I
L
D
E
P
T
A
G
L
D
P
K
G
K
Q
E
I
L
N
K
I
K
E
I
H
-
D
-
K
Y
-
K
--
M
I
T
I
L
V
S
H
N
-
M
E
D
I
A
R
I
-
A
D
K
I
I
V
M
N
R
G
K
I
E
L
I
G
T
P
R
-----
E
-------
V
F
R
E
A
E
-----------------------
78
PsiBlast_CBE
68.82
35%
-112
- C1 -
2OLK
1
?
D:
[24-240]
-
M
I
D
V
H
Q
L
K
K
S
F
G
-----
S
L
E
V
L
K
G
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
E
D
F
D
E
G
E
I
I
I
D
G
I
---
N
L
K
A
K
D
---
T
N
L
N
K
V
R
E
E
------
V
G
M
V
F
Q
--
R
F
N
L
F
P
H
M
T
V
L
------
N
N
I
T
-
L
A
P
M
K
------
V
------
R
K
W
---
P
R
E
K
A
E
A
K
A
M
E
L
L
D
K
V
G
L
-
K
D
-
K
A
-
H
A
Y
P
D
-----------
S
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
S
V
M
K
Q
L
A
-
N
-
E
G
-
M
--
T
M
-
V
V
V
T
H
E
M
G
F
A
-
R
E
V
-
G
D
R
V
L
F
M
D
G
G
Y
I
-----
I
E
-----
E
------------------------------------
70
PsiBlast_CBE
68.57
35%
-114
- C1 -
3C4J
4
?
B:
[24-240]
-
M
I
D
V
H
Q
L
K
K
S
F
G
-----
S
L
E
V
L
K
G
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
E
D
F
D
E
G
E
I
I
I
D
G
I
---
N
L
K
A
K
D
---
T
N
L
N
K
V
R
E
E
------
V
G
M
V
F
Q
--
R
F
N
L
F
P
H
M
T
V
L
------
N
N
I
T
-
L
A
P
M
K
------
V
------
R
K
W
---
P
R
E
K
A
E
A
K
A
M
E
L
L
D
K
V
G
L
-
K
D
-
K
A
-
H
A
Y
P
D
-----------
S
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
S
V
M
K
Q
L
A
-
N
-
E
G
-
M
--
T
M
-
V
V
V
T
H
E
M
G
F
A
-
R
E
V
-
G
D
R
V
L
F
M
D
G
G
Y
I
-----
I
E
-----
E
------------------------------------
85
PsiBlast_CBE
68.30
35%
-106
- C1 -
3C41
3
?
J:
[3-219]
-
M
I
D
V
H
Q
L
K
K
S
F
G
-----
S
L
E
V
L
K
G
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
E
D
F
D
E
G
E
I
I
I
D
G
I
---
N
L
K
A
K
D
---
T
N
L
N
K
V
R
E
E
------
V
G
M
V
F
Q
--
R
F
N
L
F
P
H
M
T
V
L
------
N
N
I
T
-
L
A
P
M
K
------
V
------
R
K
W
---
P
R
E
K
A
E
A
K
A
M
E
L
L
D
K
V
G
L
-
K
D
-
K
A
-
H
A
Y
P
D
-----------
S
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
S
V
M
K
Q
L
A
-
N
-
E
G
-
M
--
T
M
-
V
V
V
T
H
E
M
G
F
A
-
R
E
V
-
G
D
R
V
L
F
M
D
G
G
Y
I
-----
I
E
-----
E
------------------------------------
83
PsiBlast_CBE
67.78
35%
-118
- C1 -
2OLJ
4
?
A:
[24-240]
-
M
I
D
V
H
Q
L
K
K
S
F
G
-----
S
L
E
V
L
K
G
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
E
D
F
D
E
G
E
I
I
I
D
G
I
---
N
L
K
A
K
D
---
T
N
L
N
K
V
R
E
E
------
V
G
M
V
F
Q
--
R
F
N
L
F
P
H
M
T
V
L
------
N
N
I
T
-
L
A
P
M
K
------
V
------
R
K
W
---
P
R
E
K
A
E
A
K
A
M
E
L
L
D
K
V
G
L
-
K
D
-
K
A
-
H
A
Y
P
D
-----------
S
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
S
V
M
K
Q
L
A
-
N
-
E
G
-
M
--
T
M
-
V
V
V
T
H
E
M
G
F
A
-
R
E
V
-
G
D
R
V
L
F
M
D
G
G
Y
I
-----
I
E
-----
E
------------------------------------
79
PsiBlast_CBE
67.27
35%
-114
- C1 -
2OLK
1
?
C:
[24-240]
-
M
I
D
V
H
Q
L
K
K
S
F
G
-----
S
L
E
V
L
K
G
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
E
D
F
D
E
G
E
I
I
I
D
G
I
---
N
L
K
A
K
D
---
T
N
L
N
K
V
R
E
E
------
V
G
M
V
F
Q
--
R
F
N
L
F
P
H
M
T
V
L
------
N
N
I
T
-
L
A
P
M
K
------
V
------
R
K
W
---
P
R
E
K
A
E
A
K
A
M
E
L
L
D
K
V
G
L
-
K
D
-
K
A
-
H
A
Y
P
D
-----------
S
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
S
V
M
K
Q
L
A
-
N
-
E
G
-
M
--
T
M
-
V
V
V
T
H
E
M
G
F
A
-
R
E
V
-
G
D
R
V
L
F
M
D
G
G
Y
I
-----
I
E
-----
E
------------------------------------
80
PsiBlast_CBE
66.84
35%
-111
- C1 -
2OLK
2
?
B:
[24-240]
-
M
I
D
V
H
Q
L
K
K
S
F
G
-----
S
L
E
V
L
K
G
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
E
D
F
D
E
G
E
I
I
I
D
G
I
---
N
L
K
A
K
D
---
T
N
L
N
K
V
R
E
E
------
V
G
M
V
F
Q
--
R
F
N
L
F
P
H
M
T
V
L
------
N
N
I
T
-
L
A
P
M
K
------
V
------
R
K
W
---
P
R
E
K
A
E
A
K
A
M
E
L
L
D
K
V
G
L
-
K
D
-
K
A
-
H
A
Y
P
D
-----------
S
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
S
V
M
K
Q
L
A
-
N
-
E
G
-
M
--
T
M
-
V
V
V
T
H
E
M
G
F
A
-
R
E
V
-
G
D
R
V
L
F
M
D
G
G
Y
I
-----
I
E
-----
E
------------------------------------
73
PsiBlast_CBE
66.31
35%
-108
- C1 -
2Q0H
4
?
A:
[24-240]
-
M
I
D
V
H
Q
L
K
K
S
F
G
-----
S
L
E
V
L
K
G
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
E
D
F
D
E
G
E
I
I
I
D
G
I
---
N
L
K
A
K
D
---
T
N
L
N
K
V
R
E
E
------
V
G
M
V
F
Q
--
R
F
N
L
F
P
H
M
T
V
L
------
N
N
I
T
-
L
A
P
M
K
------
V
------
R
K
W
---
P
R
E
K
A
E
A
K
A
M
E
L
L
D
K
V
G
L
-
K
D
-
K
A
-
H
A
Y
P
D
-----------
S
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
S
V
M
K
Q
L
A
-
N
-
E
G
-
M
--
T
M
-
V
V
V
T
H
E
M
G
F
A
-
R
E
V
-
G
D
R
V
L
F
M
D
G
G
Y
I
-----
I
E
-----
E
------------------------------------
81
PsiBlast_CBE
65.74
35%
-113
- C1 -
2OLK
1
?
A:
[24-240]
-
M
I
D
V
H
Q
L
K
K
S
F
G
-----
S
L
E
V
L
K
G
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
E
D
F
D
E
G
E
I
I
I
D
G
I
---
N
L
K
A
K
D
---
T
N
L
N
K
V
R
E
E
------
V
G
M
V
F
Q
--
R
F
N
L
F
P
H
M
T
V
L
------
N
N
I
T
-
L
A
P
M
K
------
V
------
R
K
W
---
P
R
E
K
A
E
A
K
A
M
E
L
L
D
K
V
G
L
-
K
D
-
K
A
-
H
A
Y
P
D
-----------
S
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
S
V
M
K
Q
L
A
-
N
-
E
G
-
M
--
T
M
-
V
V
V
T
H
E
M
G
F
A
-
R
E
V
-
G
D
R
V
L
F
M
D
G
G
Y
I
-----
I
E
-----
E
------------------------------------
72
PsiBlast_CBE
65.70
35%
-112
- C1 -
2Q0H
4
?
B:
[24-240]
-
M
I
D
V
H
Q
L
K
K
S
F
G
-----
S
L
E
V
L
K
G
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
E
D
F
D
E
G
E
I
I
I
D
G
I
---
N
L
K
A
K
D
---
T
N
L
N
K
V
R
E
E
------
V
G
M
V
F
Q
--
R
F
N
L
F
P
H
M
T
V
L
------
N
N
I
T
-
L
A
P
M
K
------
V
------
R
K
W
---
P
R
E
K
A
E
A
K
A
M
E
L
L
D
K
V
G
L
-
K
D
-
K
A
-
H
A
Y
P
D
-----------
S
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
S
V
M
K
Q
L
A
-
N
-
E
G
-
M
--
T
M
-
V
V
V
T
H
E
M
G
F
A
-
R
E
V
-
G
D
R
V
L
F
M
D
G
G
Y
I
-----
I
E
-----
E
------------------------------------
71
PsiBlast_CBE
65.47
35%
-108
- C1 -
3C4J
3
?
A:
[24-240]
-
M
I
D
V
H
Q
L
K
K
S
F
G
-----
S
L
E
V
L
K
G
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
E
D
F
D
E
G
E
I
I
I
D
G
I
---
N
L
K
A
K
D
---
T
N
L
N
K
V
R
E
E
------
V
G
M
V
F
Q
--
R
F
N
L
F
P
H
M
T
V
L
------
N
N
I
T
-
L
A
P
M
K
------
V
------
R
K
W
---
P
R
E
K
A
E
A
K
A
M
E
L
L
D
K
V
G
L
-
K
D
-
K
A
-
H
A
Y
P
D
-----------
S
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
S
V
M
K
Q
L
A
-
N
-
E
G
-
M
--
T
M
-
V
V
V
T
H
E
M
G
F
A
-
R
E
V
-
G
D
R
V
L
F
M
D
G
G
Y
I
-----
I
E
-----
E
------------------------------------
82
PsiBlast_CBE
64.49
35%
-106
- C1 -
2OLJ
3
?
B:
[24-240]
-
M
I
D
V
H
Q
L
K
K
S
F
G
-----
S
L
E
V
L
K
G
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
E
D
F
D
E
G
E
I
I
I
D
G
I
---
N
L
K
A
K
D
---
T
N
L
N
K
V
R
E
E
------
V
G
M
V
F
Q
--
R
F
N
L
F
P
H
M
T
V
L
------
N
N
I
T
-
L
A
P
M
K
------
V
------
R
K
W
---
P
R
E
K
A
E
A
K
A
M
E
L
L
D
K
V
G
L
-
K
D
-
K
A
-
H
A
Y
P
D
-----------
S
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
S
V
M
K
Q
L
A
-
N
-
E
G
-
M
--
T
M
-
V
V
V
T
H
E
M
G
F
A
-
R
E
V
-
G
D
R
V
L
F
M
D
G
G
Y
I
-----
I
E
-----
E
------------------------------------
84
PsiBlast_CBE
64.40
35%
-113
- C1 -
3C41
3
?
K:
[3-219]
-
M
I
D
V
H
Q
L
K
K
S
F
G
-----
S
L
E
V
L
K
G
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
E
D
F
D
E
G
E
I
I
I
D
G
I
---
N
L
K
A
K
D
---
T
N
L
N
K
V
R
E
E
------
V
G
M
V
F
Q
--
R
F
N
L
F
P
H
M
T
V
L
------
N
N
I
T
-
L
A
P
M
K
------
V
------
R
K
W
---
P
R
E
K
A
E
A
K
A
M
E
L
L
D
K
V
G
L
-
K
D
-
K
A
-
H
A
Y
P
D
-----------
S
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
S
V
M
K
Q
L
A
-
N
-
E
G
-
M
--
T
M
-
V
V
V
T
H
E
M
G
F
A
-
R
E
V
-
G
D
R
V
L
F
M
D
G
G
Y
I
-----
I
E
-----
E
------------------------------------
92
PsiBlast_CBE
60.66
32%
-81
- C1 -
2ONJ
4
Y1866_STAAM
B:
[340-566]
--
I
D
I
D
H
V
S
F
Q
Y
N
D
--
N
-
E
A
P
I
L
K
D
I
N
L
S
I
E
K
G
E
T
V
A
F
V
G
M
S
G
G
G
K
S
T
L
I
N
L
I
P
R
F
Y
D
V
T
S
G
Q
I
L
I
D
G
---
H
N
I
K
D
F
L
---
T
G
S
L
R
-
N
Q
-------
I
G
L
V
Q
Q
--
D
-
N
I
L
F
S
D
T
V
K
------
E
N
I
L
-
L
-------------------
G
---
R
P
T
A
T
D
E
E
V
V
E
A
A
K
M
A
N
A
-
H
D
-
F
I
-
M
N
L
P
Q
GYDTEVGERGV
K
L
S
G
G
Q
K
Q
R
L
S
I
A
R
I
F
L
N
N
P
P
I
L
I
L
D
E
A
T
S
A
L
D
L
E
-
S
E
S
I
I
Q
E
A
L
D
V
L
-
S
-
K
D
-
R
--
T
T
-
L
I
V
A
H
R
-
L
S
T
-
I
T
H
-
A
D
K
I
V
V
I
E
N
G
--------
H
-----
I
-------
V
E
T
G
T
H
R
E
L
I
A
K
Q
----------------
94
PsiBlast_CBE
60.30
32%
-82
- C1 -
2HYD
3
Y1866_STAAM
B:
[340-566]
--
I
D
I
D
H
V
S
F
Q
Y
N
D
--
N
-
E
A
P
I
L
K
D
I
N
L
S
I
E
K
G
E
T
V
A
F
V
G
M
S
G
G
G
K
S
T
L
I
N
L
I
P
R
F
Y
D
V
T
S
G
Q
I
L
I
D
G
---
H
N
I
K
D
F
L
---
T
G
S
L
R
-
N
Q
-------
I
G
L
V
Q
Q
--
D
-
N
I
L
F
S
D
T
V
K
------
E
N
I
L
-
L
-------------------
G
---
R
P
T
A
T
D
E
E
V
V
E
A
A
K
M
A
N
A
-
H
D
-
F
I
-
M
N
L
P
Q
GYDTEVGERGV
K
L
S
G
G
Q
K
Q
R
L
S
I
A
R
I
F
L
N
N
P
P
I
L
I
L
D
E
A
T
S
A
L
D
L
E
-
S
E
S
I
I
Q
E
A
L
D
V
L
-
S
-
K
D
-
R
--
T
T
-
L
I
V
A
H
R
-
L
S
T
-
I
T
H
-
A
D
K
I
V
V
I
E
N
G
--------
H
-----
I
-------
V
E
T
G
T
H
R
E
L
I
A
K
Q
----------------
93
PsiBlast_CBE
59.52
32%
-81
- C1 -
2ONJ
4
Y1866_STAAM
A:
[340-566]
--
I
D
I
D
H
V
S
F
Q
Y
N
D
--
N
-
E
A
P
I
L
K
D
I
N
L
S
I
E
K
G
E
T
V
A
F
V
G
M
S
G
G
G
K
S
T
L
I
N
L
I
P
R
F
Y
D
V
T
S
G
Q
I
L
I
D
G
---
H
N
I
K
D
F
L
---
T
G
S
L
R
-
N
Q
-------
I
G
L
V
Q
Q
--
D
-
N
I
L
F
S
D
T
V
K
------
E
N
I
L
-
L
-------------------
G
---
R
P
T
A
T
D
E
E
V
V
E
A
A
K
M
A
N
A
-
H
D
-
F
I
-
M
N
L
P
Q
GYDTEVGERGV
K
L
S
G
G
Q
K
Q
R
L
S
I
A
R
I
F
L
N
N
P
P
I
L
I
L
D
E
A
T
S
A
L
D
L
E
-
S
E
S
I
I
Q
E
A
L
D
V
L
-
S
-
K
D
-
R
--
T
T
-
L
I
V
A
H
R
-
L
S
T
-
I
T
H
-
A
D
K
I
V
V
I
E
N
G
--------
H
-----
I
-------
V
E
T
G
T
H
R
E
L
I
A
K
Q
----------------
95
PsiBlast_CBE
58.95
32%
-81
- C1 -
2HYD
3
Y1866_STAAM
A:
[340-566]
--
I
D
I
D
H
V
S
F
Q
Y
N
D
--
N
-
E
A
P
I
L
K
D
I
N
L
S
I
E
K
G
E
T
V
A
F
V
G
M
S
G
G
G
K
S
T
L
I
N
L
I
P
R
F
Y
D
V
T
S
G
Q
I
L
I
D
G
---
H
N
I
K
D
F
L
---
T
G
S
L
R
-
N
Q
-------
I
G
L
V
Q
Q
--
D
-
N
I
L
F
S
D
T
V
K
------
E
N
I
L
-
L
-------------------
G
---
R
P
T
A
T
D
E
E
V
V
E
A
A
K
M
A
N
A
-
H
D
-
F
I
-
M
N
L
P
Q
GYDTEVGERGV
K
L
S
G
G
Q
K
Q
R
L
S
I
A
R
I
F
L
N
N
P
P
I
L
I
L
D
E
A
T
S
A
L
D
L
E
-
S
E
S
I
I
Q
E
A
L
D
V
L
-
S
-
K
D
-
R
--
T
T
-
L
I
V
A
H
R
-
L
S
T
-
I
T
H
-
A
D
K
I
V
V
I
E
N
G
--------
H
-----
I
-------
V
E
T
G
T
H
R
E
L
I
A
K
Q
----------------
91
PsiBlast_CBE
45.26
34%
-88
- C1 -
4S0F
2
?
A:
[505-701]
----------------------
L
K
N
I
N
L
T
I
P
K
G
K
T
V
A
I
V
G
E
S
G
S
G
K
T
T
L
A
K
L
L
M
N
F
Y
S
P
E
K
G
D
I
L
I
N
G
---
H
S
I
K
N
I
S
---
L
E
L
I
R
-
K
K
-------
I
A
F
V
S
Q
--
D
V
F
I
F
S
G
T
V
K
E
N
L
C
LGN
E
N
V
D
-
M
-
D
E
I
------
I
------
K
A
A
---
K
M
A
N
A
H
D
F
I
E
K
L
P
--
L
K
Y
-
D
T
-
F
L
-
N
E
S
G
A
-----------
N
L
S
E
G
Q
K
Q
R
L
A
I
A
R
A
L
L
K
K
P
D
I
L
I
L
D
Q
A
T
S
N
L
D
S
I
T
E
N
H
I
K
---
D
A
I
Y
-
G
-
L
E
-
D
D
V
T
V
-
I
I
I
A
H
R
-
L
S
T
-
I
V
N
-
C
D
K
I
Y
L
L
K
D
G
E
I
-------------------------------------------------
90
PsiBlast_CBE
43.13
34%
-90
- C1 -
4S0F
2
?
B:
[505-701]
----------------------
L
K
N
I
N
L
T
I
P
K
G
K
T
V
A
I
V
G
E
S
G
S
G
K
T
T
L
A
K
L
L
M
N
F
Y
S
P
E
K
G
D
I
L
I
N
G
---
H
S
I
K
N
I
S
---
L
E
L
I
R
-
K
K
-------
I
A
F
V
S
Q
--
D
V
F
I
F
S
G
T
V
K
E
NLCLGN
E
N
V
D
-
M
-
D
E
I
------
I
------
K
A
A
---
K
M
A
N
A
H
D
F
I
E
K
L
P
--
L
K
Y
-
D
T
-
F
L
-
N
E
S
G
A
-----------
N
L
S
E
G
Q
K
Q
R
L
A
I
A
R
A
L
L
K
K
P
D
I
L
I
L
D
Q
A
T
S
N
L
D
S
I
T
E
N
H
I
K
---
D
A
I
Y
-
G
-
L
E
-
D
DV
T
V
-
I
I
I
A
H
R
-
L
S
T
-
I
V
N
-
C
D
K
I
Y
L
L
K
D
G
E
I
-------------------------------------------------