@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : SA2425: (2016-04-04 )
MKEKIVIALGGNAIQTKEATAEAQQTAIRRAMQNLKPLFDSPARIVISHGNGPQIGSLLIQQAKSNSDTTPAMPLDTCGAMSQGMIGYWLETEINRILTEMNSDRTVGTIVTRVEVDKDDPRFNNPTKPIGPFYTKEEVEELQKEQPDSVFKEDAGRGYRKVVASPLPQSILEHQLIRTLADGKNIVIACGGGGIPVIKKENTYEGVEAVIDKDFASEKLATLIEADTLMILTNVENVFINFNEPNQQQIDDIDVATLKKYAAQGKFAEGSMLPKIEAAIRFVESGENKKVIITNLEQAYEALIGNKGTHIHM
Atome Classification :
(36 SA)
.........10..-....--.-.20--........30........40........50........60.-.-......70.....-...80........90........100.......110.......120.......130......---.140-------.........---150.......160.......170.---......180.......190....-...200........210.......220.......230.....--..240.......250.......260.......270.......280.......290.....-..300....-...310.-
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MK
E
K
I
V
I
A
LGG
N
A
-IQ
T
K
--
E
-
A
T
A
--
E
A
Q
Q
T
A
I
R
R
A
M
Q
N
L
K
P
L
FDSP
A
R
I
V
I
SHGNGP
Q
I
G
S
L
L
I
Q
Q
-A-KSNSDTTPAMPL
D
-
T
C
G
A
M
SQG
M
I
G
Y
W
L
E
T
E
I
N
R
I
L
T
E
MNSDR
T
V
G
T
I
V
T
R
V
E
VDKDDPRFNNPTKPIGPFY
T
K
E
E
---
V
E
---------
E
L
Q
K
EQ
P
D
S
---
V
F
K
E
D
AGR
G
Y
R
K
V
VASPL
P
Q
S
I
L
E
---
H
Q
L
I
R
T
LADGK
N
I
V
I
A
CGGGG
I
P
-
V
I
KK-ENT
Y
E
G
V
E
A
V
I
D
K
D
F
A
S
E
K
L
A
T
L
IEA
D
T
L
M
I
L
TNV
E
N
--
V
F
I
NFNEP
N
Q
Q
Q
IDDI
D
V
A
T
L
K
K
Y
A
AQGKFAEGSML
P
K
I
E
A
A
I
R
F
V
ESGEN
K
K
V
I
I
T
N
L
E
-
Q
A
Y
E
A
L
IGN-KGTHIHM-
21
PsiBlast_CBE
96.42
54%
-91
- C5 -
2WE5
1
ARCC1_ENTFA
C:
[2-293]
-
G
K
K
M
V
V
A
L
G
G
N
A
-
I
L
S
N
--
D
-
A
S
A
--
H
A
Q
Q
Q
A
L
V
Q
T
S
A
Y
L
V
H
L
I
K
Q
G
H
R
L
I
V
S
H
G
N
G
P
Q
V
G
N
L
L
L
Q
Q
-
Q
-
A
A
D
S
E
K
N
P
A
M
P
L
D
-
T
C
V
A
M
T
Q
G
S
I
G
Y
W
L
S
N
A
L
N
Q
E
L
N
K
A
G
I
K
K
Q
V
A
T
V
L
T
Q
V
V
V
D
P
A
D
E
A
F
K
N
P
T
K
P
I
G
P
F
L
T
E
A
E
---
A
K
---------
E
A
M
--
Q
A
G
A
---
I
F
K
E
D
A
G
R
G
W
R
K
V
V
P
S
P
K
P
I
D
I
H
E
---
A
E
T
I
N
T
L
I
K
N
D
I
I
T
I
S
C
G
G
G
G
I
P
-
V
V
G
Q
-
E
--
L
K
G
V
E
A
V
I
D
K
D
F
A
S
E
K
L
A
E
L
V
D
A
D
A
L
V
I
L
T
G
V
D
Y
--
V
C
I
N
Y
G
K
P
D
E
K
Q
L
T
N
V
T
V
A
E
L
E
E
Y
K
Q
A
G
H
F
A
P
G
S
M
L
P
K
I
E
A
A
I
Q
F
V
E
S
Q
P
N
K
Q
A
I
I
T
S
L
E
-------------------
3
PsiBlast_PDB
95.74
54%
-90
- C5 -
2WE5
2
ARCC1_ENTFA
A:
[2-293]
-
G
K
K
M
V
V
A
L
G
G
N
A
-
I
L
S
N
--
D
-
A
S
A
--
H
A
Q
Q
Q
A
L
V
Q
T
S
A
Y
L
V
H
L
I
K
Q
G
H
R
L
I
V
S
H
G
N
G
P
Q
V
G
N
L
L
L
Q
Q
-
Q
-
A
A
D
S
E
K
N
P
A
M
P
L
D
-
T
C
V
A
M
T
Q
G
S
I
G
Y
W
L
S
N
A
L
N
Q
E
L
N
K
A
G
I
K
K
Q
V
A
T
V
L
T
Q
V
V
V
D
P
A
D
E
A
F
K
N
P
T
K
P
I
G
P
F
L
T
E
A
E
---
A
K
---------
E
A
M
--
Q
A
G
A
---
I
F
K
E
D
A
G
R
G
W
R
K
V
V
P
S
P
K
P
I
D
I
H
E
---
A
E
T
I
N
T
L
I
K
N
D
I
I
T
I
S
C
G
G
G
G
I
P
-
V
V
G
Q
-
E
--
L
K
G
V
E
A
V
I
D
K
D
F
A
S
E
K
L
A
E
L
V
D
A
D
A
L
V
I
L
T
G
V
D
Y
--
V
C
I
N
Y
G
K
P
D
E
K
Q
L
T
N
V
T
V
A
E
L
E
E
Y
K
Q
A
G
H
F
A
P
G
S
M
L
P
K
I
E
A
A
I
Q
F
V
E
S
Q
P
N
K
Q
A
I
I
T
S
L
E
-------------------
24
PsiBlast_CBE
95.49
54%
-88
- C5 -
2WE4
3
ARCC1_ENTFA
C:
[2-293]
-
G
K
K
M
V
V
A
L
G
G
N
A
-
I
L
S
N
--
D
-
A
S
A
--
H
A
Q
Q
Q
A
L
V
Q
T
S
A
Y
L
V
H
L
I
K
Q
G
H
R
L
I
V
S
H
G
N
G
P
Q
V
G
N
L
L
L
Q
Q
-
Q
-
A
A
D
S
E
K
N
P
A
M
P
L
D
-
T
C
V
A
M
T
Q
G
S
I
G
Y
W
L
S
N
A
L
N
Q
E
L
N
K
A
G
I
K
K
Q
V
A
T
V
L
T
Q
V
V
V
D
P
A
D
E
A
F
K
N
P
T
K
P
I
G
P
F
L
T
E
A
E
---
A
K
---------
E
A
M
--
Q
A
G
A
---
I
F
K
E
D
A
G
R
G
W
R
K
V
V
P
S
P
K
P
I
D
I
H
E
---
A
E
T
I
N
T
L
I
K
N
D
I
I
T
I
S
C
G
G
G
G
I
P
-
V
V
G
Q
-
E
--
L
K
G
V
E
A
V
I
D
K
D
F
A
S
E
K
L
A
E
L
V
D
A
D
A
L
V
I
L
T
G
V
D
Y
--
V
C
I
N
Y
G
K
P
D
E
K
Q
L
T
N
V
T
V
A
E
L
E
E
Y
K
Q
A
G
H
F
A
P
G
S
M
L
P
K
I
E
A
A
I
Q
F
V
E
S
Q
P
N
K
Q
A
I
I
T
S
L
E
-------------------
22
PsiBlast_CBE
95.15
54%
-90
- C5 -
2WE5
1
ARCC1_ENTFA
B:
[2-293]
-
G
K
K
M
V
V
A
L
G
G
N
A
-
I
L
S
N
--
D
-
A
S
A
--
H
A
Q
Q
Q
A
L
V
Q
T
S
A
Y
L
V
H
L
I
K
Q
G
H
R
L
I
V
S
H
G
N
G
P
Q
V
G
N
L
L
L
Q
Q
-
Q
-
A
A
D
S
E
K
N
P
A
M
P
L
D
-
T
C
V
A
M
T
Q
G
S
I
G
Y
W
L
S
N
A
L
N
Q
E
L
N
K
A
G
I
K
K
Q
V
A
T
V
L
T
Q
V
V
V
D
P
A
D
E
A
F
K
N
P
T
K
P
I
G
P
F
L
T
E
A
E
---
A
K
---------
E
A
M
--
Q
A
G
A
---
I
F
K
E
D
A
G
R
G
W
R
K
V
V
P
S
P
K
P
I
D
I
H
E
---
A
E
T
I
N
T
L
I
K
N
D
I
I
T
I
S
C
G
G
G
G
I
P
-
V
V
G
Q
-
E
--
L
K
G
V
E
A
V
I
D
K
D
F
A
S
E
K
L
A
E
L
V
D
A
D
A
L
V
I
L
T
G
V
D
Y
--
V
C
I
N
Y
G
K
P
D
E
K
Q
L
T
N
V
T
V
A
E
L
E
E
Y
K
Q
A
G
H
F
A
P
G
S
M
L
P
K
I
E
A
A
I
Q
F
V
E
S
Q
P
N
K
Q
A
I
I
T
S
L
E
-------------------
28
PsiBlast_CBE
95.12
54%
-88
- C5 -
1B7B
1
ARCC1_ENTFC
B:
[2-293]
-
G
K
K
M
V
V
A
L
G
G
N
A
-
I
L
S
N
--
D
-
A
S
A
--
H
A
Q
Q
Q
A
L
V
Q
T
S
A
Y
L
V
H
L
I
K
Q
G
H
R
L
I
V
S
H
G
N
G
P
Q
V
G
N
L
L
L
Q
Q
-
Q
-
A
A
D
S
E
K
N
P
A
M
P
L
D
-
T
C
V
A
M
T
Q
G
S
I
G
Y
W
L
S
N
A
L
N
Q
E
L
N
K
A
G
I
K
K
Q
V
A
T
V
L
T
Q
V
V
V
D
P
A
D
E
A
F
K
N
P
T
K
P
I
G
P
F
L
T
E
A
E
---
A
K
---------
E
A
M
--
Q
A
G
A
---
I
F
K
E
D
A
G
R
G
W
R
K
V
V
P
S
P
K
P
I
D
I
H
E
---
A
E
T
I
N
T
L
I
K
N
D
I
I
T
I
S
C
G
G
G
G
I
P
-
V
V
G
Q
-
E
--
L
K
G
V
E
A
V
I
D
K
D
F
A
S
E
K
L
A
E
L
V
D
A
D
A
L
V
I
L
T
G
V
D
Y
--
V
C
I
N
Y
G
K
P
D
E
K
Q
L
T
N
V
T
V
A
E
L
E
E
Y
K
Q
A
G
H
F
A
P
G
S
M
L
P
K
I
E
A
A
I
Q
F
V
E
S
Q
P
N
K
Q
A
I
I
T
S
L
E
-------------------
27
PsiBlast_CBE
95.06
54%
-87
- C5 -
1B7B
1
ARCC1_ENTFC
C:
[2-293]
-
G
K
K
M
V
V
A
L
G
G
N
A
-
I
L
S
N
--
D
-
A
S
A
--
H
A
Q
Q
Q
A
L
V
Q
T
S
A
Y
L
V
H
L
I
K
Q
G
H
R
L
I
V
S
H
G
N
G
P
Q
V
G
N
L
L
L
Q
Q
-
Q
-
A
A
D
S
E
K
N
P
A
M
P
L
D
-
T
C
V
A
M
T
Q
G
S
I
G
Y
W
L
S
N
A
L
N
Q
E
L
N
K
A
G
I
K
K
Q
V
A
T
V
L
T
Q
V
V
V
D
P
A
D
E
A
F
K
N
P
T
K
P
I
G
P
F
L
T
E
A
E
---
A
K
---------
E
A
M
--
Q
A
G
A
---
I
F
K
E
D
A
G
R
G
W
R
K
V
V
P
S
P
K
P
I
D
I
H
E
---
A
E
T
I
N
T
L
I
K
N
D
I
I
T
I
S
C
G
G
G
G
I
P
-
V
V
G
Q
-
E
--
L
K
G
V
E
A
V
I
D
K
D
F
A
S
E
K
L
A
E
L
V
D
A
D
A
L
V
I
L
T
G
V
D
Y
--
V
C
I
N
Y
G
K
P
D
E
K
Q
L
T
N
V
T
V
A
E
L
E
E
Y
K
Q
A
G
H
F
A
P
G
S
M
L
P
K
I
E
A
A
I
Q
F
V
E
S
Q
P
N
K
Q
A
I
I
T
S
L
E
-------------------
25
PsiBlast_CBE
94.92
54%
-85
- C5 -
2WE4
5
ARCC1_ENTFA
B:
[2-293]
-
G
K
K
M
V
V
A
L
G
G
N
A
-
I
L
S
N
--
D
-
A
S
A
--
H
A
Q
Q
Q
A
L
V
Q
T
S
A
Y
L
V
H
L
I
K
Q
G
H
R
L
I
V
S
H
G
N
G
P
Q
V
G
N
L
L
L
Q
Q
-
Q
-
A
A
D
S
E
K
N
P
A
M
P
L
D
-
T
C
V
A
M
T
Q
G
S
I
G
Y
W
L
S
N
A
L
N
Q
E
L
N
K
A
G
I
K
K
Q
V
A
T
V
L
T
Q
V
V
V
D
P
A
D
E
A
F
K
N
P
T
K
P
I
G
P
F
L
T
E
A
E
---
A
K
---------
E
A
M
--
Q
A
G
A
---
I
F
K
E
D
A
G
R
G
W
R
K
V
V
P
S
P
K
P
I
D
I
H
E
---
A
E
T
I
N
T
L
I
K
N
D
I
I
T
I
S
C
G
G
G
G
I
P
-
V
V
G
Q
-
E
--
L
K
G
V
E
A
V
I
D
K
D
F
A
S
E
K
L
A
E
L
V
D
A
D
A
L
V
I
L
T
G
V
D
Y
--
V
C
I
N
Y
G
K
P
D
E
K
Q
L
T
N
V
T
V
A
E
L
E
E
Y
K
Q
A
G
H
F
A
P
G
S
M
L
P
K
I
E
A
A
I
Q
F
V
E
S
Q
P
N
K
Q
A
I
I
T
S
L
E
-------------------
1
PsiBlast_PDB
94.64
54%
-90
- C5 -
1B7B
1
ARCC1_ENTFC
A:
[2-293]
-
G
K
K
M
V
V
A
L
G
G
N
A
-
I
L
S
N
--
D
-
A
S
A
--
H
A
Q
Q
Q
A
L
V
Q
T
S
A
Y
L
V
H
L
I
K
Q
G
H
R
L
I
V
S
H
G
N
G
P
Q
V
G
N
L
L
L
Q
Q
-
Q
-
A
A
D
S
E
K
N
P
A
M
P
L
D
-
T
C
V
A
M
T
Q
G
S
I
G
Y
W
L
S
N
A
L
N
Q
E
L
N
K
A
G
I
K
K
Q
V
A
T
V
L
T
Q
V
V
V
D
P
A
D
E
A
F
K
N
P
T
K
P
I
G
P
F
L
T
E
A
E
---
A
K
---------
E
A
M
--
Q
A
G
A
---
I
F
K
E
D
A
G
R
G
W
R
K
V
V
P
S
P
K
P
I
D
I
H
E
---
A
E
T
I
N
T
L
I
K
N
D
I
I
T
I
S
C
G
G
G
G
I
P
-
V
V
G
Q
-
E
--
L
K
G
V
E
A
V
I
D
K
D
F
A
S
E
K
L
A
E
L
V
D
A
D
A
L
V
I
L
T
G
V
D
Y
--
V
C
I
N
Y
G
K
P
D
E
K
Q
L
T
N
V
T
V
A
E
L
E
E
Y
K
Q
A
G
H
F
A
P
G
S
M
L
P
K
I
E
A
A
I
Q
F
V
E
S
Q
P
N
K
Q
A
I
I
T
S
L
E
-------------------
68
Fugue
94.50
51%
-87
- C5 -
1B7B
1
ARCC1_ENTFC
A:
[2-308]
-
G
K
K
M
V
V
A
L
G
G
N
A
-
I
L
S
N
--
D
-
A
S
A
--
H
A
Q
Q
Q
A
L
V
Q
T
S
A
Y
L
V
H
L
I
K
Q
G
H
R
L
I
V
S
H
G
N
G
P
Q
V
G
N
L
L
L
Q
Q
-
Q
-
A
A
D
S
E
K
N
P
A
M
P
L
D
-
T
C
V
A
M
T
Q
G
S
I
G
Y
W
L
S
N
A
L
N
Q
E
L
N
K
A
G
I
K
K
Q
V
A
T
V
L
T
Q
V
V
V
D
P
A
D
E
A
F
K
N
P
T
K
P
I
G
P
F
L
T
E
A
E
---
A
K
---------
E
A
M
Q
A
--
G
A
---
I
F
K
E
D
A
G
R
G
W
R
K
V
V
P
S
P
K
P
I
D
I
H
E
---
A
E
T
I
N
T
L
I
K
N
D
I
I
T
I
S
C
G
G
G
G
I
P
-
V
V
G
---
Q
E
L
K
G
V
E
A
V
I
D
K
D
F
A
S
E
K
L
A
E
L
V
D
A
D
A
L
V
I
L
T
G
V
D
Y
--
V
C
I
N
Y
G
K
P
D
E
K
Q
L
T
N
V
T
V
A
E
L
E
E
Y
K
Q
A
G
H
F
A
P
G
S
M
L
P
K
I
E
A
A
I
Q
F
V
E
S
Q
P
N
K
Q
A
I
I
T
S
L
E
-
N
L
G
S
--
M
S
G
-
D
E
I
V
G
T
V
V
67
Fugue
94.31
52%
-78
- C5 -
1B7B
1
ARCC1_ENTFC
A:
[2-308]
-
G
K
K
M
V
V
A
L
G
G
N
A
-
I
L
S
N
--
D
-
A
S
A
--
H
A
Q
Q
Q
A
L
V
Q
T
S
A
Y
L
V
H
L
I
K
Q
G
H
R
L
I
V
S
H
G
N
G
P
Q
V
G
N
L
L
L
Q
Q
-
Q
-
A
A
D
S
E
K
N
P
A
M
P
L
D
-
T
C
V
A
M
T
Q
G
S
I
G
Y
W
L
S
N
A
L
N
Q
E
L
N
K
A
G
I
K
K
Q
V
A
T
V
L
T
Q
V
V
V
D
P
A
D
E
A
F
K
N
P
T
K
P
I
G
P
F
L
T
E
A
E
---
A
K
---------
E
A
M
Q
--
A
G
A
---
I
F
K
E
D
A
G
R
G
W
R
K
V
V
P
S
P
K
P
I
D
I
H
E
---
A
E
T
I
N
T
L
I
K
N
D
I
I
T
I
S
C
G
G
G
G
I
P
-
V
V
G
Q
-
E
L
--
K
G
V
E
A
V
I
D
K
D
F
A
S
E
K
L
A
E
L
V
D
A
D
A
L
V
I
L
T
G
V
D
Y
--
V
C
I
N
Y
G
K
P
D
E
K
Q
L
T
N
V
T
V
A
E
L
E
E
Y
K
Q
A
G
H
F
A
P
G
S
M
L
P
K
I
E
A
A
I
Q
F
V
E
S
Q
P
N
K
Q
A
I
I
T
S
L
E
-
N
L
-
G
S
M
S
G
D
-
E
I
V
G
T
V
V
-
26
PsiBlast_CBE
94.14
54%
-89
- C5 -
1B7B
1
ARCC1_ENTFC
D:
[2-293]
-
G
K
K
M
V
V
A
L
G
G
N
A
-
I
L
S
N
--
D
-
A
S
A
--
H
A
Q
Q
Q
A
L
V
Q
T
S
A
Y
L
V
H
L
I
K
Q
G
H
R
L
I
V
S
H
G
N
G
P
Q
V
G
N
L
L
L
Q
Q
-
Q
-
A
A
D
S
E
K
N
P
A
M
P
L
D
-
T
C
V
A
M
T
Q
G
S
I
G
Y
W
L
S
N
A
L
N
Q
E
L
N
K
A
G
I
K
K
Q
V
A
T
V
L
T
Q
V
V
V
D
P
A
D
E
A
F
K
N
P
T
K
P
I
G
P
F
L
T
E
A
E
---
A
K
---------
E
A
M
--
Q
A
G
A
---
I
F
K
E
D
A
G
R
G
W
R
K
V
V
P
S
P
K
P
I
D
I
H
E
---
A
E
T
I
N
T
L
I
K
N
D
I
I
T
I
S
C
G
G
G
G
I
P
-
V
V
G
Q
-
E
--
L
K
G
V
E
A
V
I
D
K
D
F
A
S
E
K
L
A
E
L
V
D
A
D
A
L
V
I
L
T
G
V
D
Y
--
V
C
I
N
Y
G
K
P
D
E
K
Q
L
T
N
V
T
V
A
E
L
E
E
Y
K
Q
A
G
H
F
A
P
G
S
M
L
P
K
I
E
A
A
I
Q
F
V
E
S
Q
P
N
K
Q
A
I
I
T
S
L
E
-------------------
2
PsiBlast_PDB
93.99
54%
-87
- C5 -
2WE4
4
ARCC1_ENTFA
A:
[2-293]
-
G
K
K
M
V
V
A
L
G
G
N
A
-
I
L
S
N
--
D
-
A
S
A
--
H
A
Q
Q
Q
A
L
V
Q
T
S
A
Y
L
V
H
L
I
K
Q
G
H
R
L
I
V
S
H
G
N
G
P
Q
V
G
N
L
L
L
Q
Q
-
Q
-
A
A
D
S
E
K
N
P
A
M
P
L
D
-
T
C
V
A
M
T
Q
G
S
I
G
Y
W
L
S
N
A
L
N
Q
E
L
N
K
A
G
I
K
K
Q
V
A
T
V
L
T
Q
V
V
V
D
P
A
D
E
A
F
K
N
P
T
K
P
I
G
P
F
L
T
E
A
E
---
A
K
---------
E
A
M
--
Q
A
G
A
---
I
F
K
E
D
A
G
R
G
W
R
K
V
V
P
S
P
K
P
I
D
I
H
E
---
A
E
T
I
N
T
L
I
K
N
D
I
I
T
I
S
C
G
G
G
G
I
P
-
V
V
G
Q
-
E
--
L
K
G
V
E
A
V
I
D
K
D
F
A
S
E
K
L
A
E
L
V
D
A
D
A
L
V
I
L
T
G
V
D
Y
--
V
C
I
N
Y
G
K
P
D
E
K
Q
L
T
N
V
T
V
A
E
L
E
E
Y
K
Q
A
G
H
F
A
P
G
S
M
L
P
K
I
E
A
A
I
Q
F
V
E
S
Q
P
N
K
Q
A
I
I
T
S
L
E
-------------------
23
PsiBlast_CBE
93.69
54%
-85
- C5 -
2WE4
4
ARCC1_ENTFA
D:
[2-293]
-
G
K
K
M
V
V
A
L
G
G
N
A
-
I
L
S
N
--
D
-
A
S
A
--
H
A
Q
Q
Q
A
L
V
Q
T
S
A
Y
L
V
H
L
I
K
Q
G
H
R
L
I
V
S
H
G
N
G
P
Q
V
G
N
L
L
L
Q
Q
-
Q
-
A
A
D
S
E
K
N
P
A
M
P
L
D
-
T
C
V
A
M
T
Q
G
S
I
G
Y
W
L
S
N
A
L
N
Q
E
L
N
K
A
G
I
K
K
Q
V
A
T
V
L
T
Q
V
V
V
D
P
A
D
E
A
F
K
N
P
T
K
P
I
G
P
F
L
T
E
A
E
---
A
K
---------
E
A
M
--
Q
A
G
A
---
I
F
K
E
D
A
G
R
G
W
R
K
V
V
P
S
P
K
P
I
D
I
H
E
---
A
E
T
I
N
T
L
I
K
N
D
I
I
T
I
S
C
G
G
G
G
I
P
-
V
V
G
Q
-
E
--
L
K
G
V
E
A
V
I
D
K
D
F
A
S
E
K
L
A
E
L
V
D
A
D
A
L
V
I
L
T
G
V
D
Y
--
V
C
I
N
Y
G
K
P
D
E
K
Q
L
T
N
V
T
V
A
E
L
E
E
Y
K
Q
A
G
H
F
A
P
G
S
M
L
P
K
I
E
A
A
I
Q
F
V
E
S
Q
P
N
K
Q
A
I
I
T
S
L
E
-------------------
29
PsiBlast_CBE
93.51
43%
-86
- C5 -
1E19
1
CPKA_PYRFU
B:
[2-312]
-
G
K
R
V
V
I
A
L
G
G
N
A
-
L
Q
Q
R
GQ
K
-
G
S
Y
--
E
E
M
M
D
N
V
R
K
T
A
R
Q
I
A
E
I
I
A
R
G
Y
E
V
V
I
T
H
G
N
G
P
Q
V
G
S
L
L
L
H
M
D
A
-
G
Q
A
T
Y
G
I
P
A
Q
P
M
D
-
V
A
G
A
M
S
Q
G
W
I
G
Y
M
I
Q
Q
A
L
K
N
E
L
R
K
R
G
M
E
K
K
V
V
T
I
I
T
Q
T
I
V
D
K
N
D
P
A
F
Q
N
P
T
K
P
V
G
P
F
Y
D
E
E
T
---
A
K
---------
R
L
A
R
E
K
-
G
W
---
I
V
K
E
D
S
G
R
G
W
R
R
V
V
P
S
P
D
P
K
G
H
V
E
---
A
E
T
I
K
K
L
V
E
R
G
V
I
V
I
A
S
G
G
G
G
V
P
-
V
I
L
E
-
D
G
E
I
K
G
V
E
A
V
I
D
K
D
L
A
G
E
K
L
A
E
E
V
N
A
D
I
F
M
I
L
T
D
V
N
G
--
A
A
L
Y
Y
G
T
E
K
E
Q
W
L
R
E
V
K
V
E
E
L
R
K
Y
Y
E
E
G
H
F
K
A
G
S
M
G
P
K
V
L
A
A
I
R
F
I
E
W
G
-
G
E
R
A
I
I
A
H
L
E
-
K
A
V
E
A
L
E
G
K
-
T
G
T
Q
V
---
4
PsiBlast_PDB
91.89
43%
-82
- C5 -
1E19
1
CPKA_PYRFU
A:
[2-312]
-
G
K
R
V
V
I
A
L
G
G
N
A
-
L
Q
Q
R
GQ
K
-
G
S
Y
--
E
E
M
M
D
N
V
R
K
T
A
R
Q
I
A
E
I
I
A
R
G
Y
E
V
V
I
T
H
G
N
G
P
Q
V
G
S
L
L
L
H
M
D
A
-
G
Q
A
T
Y
G
I
P
A
Q
P
M
D
-
V
A
G
A
M
S
Q
G
W
I
G
Y
M
I
Q
Q
A
L
K
N
E
L
R
K
R
G
M
E
K
K
V
V
T
I
I
T
Q
T
I
V
D
K
N
D
P
A
F
Q
N
P
T
K
P
V
G
P
F
Y
D
E
E
T
---
A
K
---------
R
L
A
R
E
K
-
G
W
---
I
V
K
E
D
S
G
R
G
W
R
R
V
V
P
S
P
D
P
K
G
H
V
E
---
A
E
T
I
K
K
L
V
E
R
G
V
I
V
I
A
S
G
G
G
G
V
P
-
V
I
L
E
-
D
G
E
I
K
G
V
E
A
V
I
D
K
D
L
A
G
E
K
L
A
E
E
V
N
A
D
I
F
M
I
L
T
D
V
N
G
--
A
A
L
Y
Y
G
T
E
K
E
Q
W
L
R
E
V
K
V
E
E
L
R
K
Y
Y
E
E
G
H
F
K
A
G
S
M
G
P
K
V
L
A
A
I
R
F
I
E
W
G
-
G
E
R
A
I
I
A
H
L
E
-
K
A
V
E
A
L
E
G
K
-
T
G
T
Q
V
---
33
PsiBlast_CBE
91.71
41%
-85
- C5 -
4JZ9
1
?
D:
[8-314]
----
V
V
I
A
L
G
G
N
A
M
L
Q
A
K
--
E
K
G
D
Y
--
D
T
Q
R
K
N
V
E
I
A
A
S
E
I
Y
K
I
H
K
A
G
Y
K
V
V
L
T
S
G
N
G
P
Q
V
G
A
I
K
L
Q
N
---
Q
A
A
A
G
V
S
P
E
M
P
L
H
-
V
C
G
A
M
S
Q
G
F
I
G
Y
M
M
S
Q
A
M
D
N
V
F
C
A
N
N
E
P
A
N
C
V
T
C
V
T
Q
T
L
V
D
P
K
D
Q
A
F
T
N
P
T
K
P
V
G
R
F
Y
T
E
Q
E
---
A
K
---------
D
L
M
A
A
N
P
G
K
---
I
L
R
E
D
A
G
R
G
W
R
V
V
V
P
S
P
R
P
L
E
I
V
E
---
Y
G
V
I
K
T
L
I
D
N
N
V
L
V
I
C
T
N
G
G
G
I
P
-
C
K
R
E
-
N
K
V
I
S
G
V
D
A
V
I
D
K
D
L
A
T
S
L
L
A
K
T
L
N
S
D
Y
L
M
I
L
T
D
V
L
N
--
A
C
I
N
Y
K
K
P
D
E
R
K
L
E
E
I
K
L
S
E
I
L
A
L
E
K
D
G
H
F
A
A
G
S
M
G
P
K
V
R
A
A
I
E
F
T
Q
A
-
T
G
K
M
S
I
I
T
S
L
S
-
T
A
V
D
A
L
N
G
K
-
C
G
T
R
I
---
8
PsiBlast_PDB
91.63
41%
-85
- C5 -
4OLC
2
?
A:
[8-314]
----
V
V
I
A
L
G
G
N
A
M
L
Q
A
K
--
E
K
G
D
Y
--
D
T
Q
R
K
N
V
E
I
A
A
S
E
I
Y
K
I
H
K
A
G
Y
K
V
V
L
T
S
G
N
G
P
Q
V
G
A
I
K
L
Q
N
---
Q
A
A
A
G
V
S
P
E
M
P
L
H
-
V
C
G
A
M
S
Q
G
F
I
G
Y
M
M
S
Q
A
M
D
N
V
F
C
A
N
N
E
P
A
N
C
V
T
C
V
T
Q
T
L
V
D
P
K
D
Q
A
F
T
N
P
T
K
P
V
G
R
F
Y
T
E
Q
E
---
A
K
---------
D
L
M
A
A
N
P
G
K
---
I
L
R
E
D
A
G
R
G
W
R
V
V
V
P
S
P
R
P
L
E
I
V
E
---
Y
G
V
I
K
T
L
I
D
N
N
V
L
V
I
C
T
N
G
G
G
I
P
-
C
K
R
E
-
N
K
V
I
S
G
V
D
A
V
I
D
K
D
L
A
T
S
L
L
A
K
T
L
N
S
D
Y
L
M
I
L
T
D
V
L
N
--
A
C
I
-------
R
K
L
E
E
I
K
L
S
E
I
L
A
L
E
K
D
G
H
F
A
A
G
S
M
G
P
K
V
R
A
A
I
E
F
T
Q
A
-
T
G
K
M
S
I
I
T
S
L
S
-
T
A
V
D
A
L
N
G
K
-
C
G
T
R
I
---
38
PsiBlast_CBE
91.57
41%
-82
- C5 -
4JZ8
1
?
B:
[8-314]
----
V
V
I
A
L
G
G
N
A
M
L
Q
A
K
--
E
K
G
D
Y
--
D
T
Q
R
K
N
V
E
I
A
A
S
E
I
Y
K
I
H
K
A
G
Y
K
V
V
L
T
S
G
N
G
P
Q
V
G
A
I
K
L
Q
N
---
Q
A
A
A
G
V
S
P
E
M
P
L
H
-
V
C
G
A
M
S
Q
G
F
I
G
Y
M
M
S
Q
A
M
D
N
V
F
C
A
N
N
E
P
A
N
C
V
T
C
V
T
Q
T
L
V
D
P
K
D
Q
A
F
T
N
P
T
K
P
V
G
R
F
Y
T
E
Q
E
---
A
K
---------
D
L
M
A
A
N
P
G
K
---
I
L
R
E
D
A
G
R
G
W
R
V
V
V
P
S
P
R
P
L
E
I
V
E
---
Y
G
V
I
K
T
L
I
D
N
N
V
L
V
I
C
T
N
G
G
G
I
P
-
C
K
R
E
-
N
K
V
I
S
G
V
D
A
V
I
D
K
D
L
A
T
S
L
L
A
K
T
L
N
S
D
Y
L
M
I
L
T
D
V
L
N
--
A
C
I
N
-----
E
R
K
L
E
E
I
K
L
S
E
I
L
A
L
E
K
D
G
H
F
A
A
G
S
M
G
P
K
V
R
A
A
I
E
F
T
Q
A
-
T
G
K
M
S
I
I
T
S
L
S
-
T
A
V
D
A
L
N
G
K
-
C
G
T
R
I
---
35
PsiBlast_CBE
91.05
41%
-81
- C5 -
4JZ9
1
?
B:
[8-314]
----
V
V
I
A
L
G
G
N
A
M
L
Q
A
K
--
E
K
G
D
Y
--
D
T
Q
R
K
N
V
E
I
A
A
S
E
I
Y
K
I
H
K
A
G
Y
K
V
V
L
T
S
G
N
G
P
Q
V
G
A
I
K
L
Q
N
---
Q
A
A
A
G
V
S
P
E
M
P
L
H
-
V
C
G
A
M
S
Q
G
F
I
G
Y
M
M
S
Q
A
M
D
N
V
F
C
A
N
N
E
P
A
N
C
V
T
C
V
T
Q
T
L
V
D
P
K
D
Q
A
F
T
N
P
T
K
P
V
G
R
F
Y
T
E
Q
E
---
A
K
---------
D
L
M
A
A
N
P
G
K
---
I
L
R
E
D
A
G
R
G
W
R
V
V
V
P
S
P
R
P
L
E
I
V
E
---
Y
G
V
I
K
T
L
I
D
N
N
V
L
V
I
C
T
N
G
G
G
I
P
-
C
K
R
E
-
N
K
V
I
S
G
V
D
A
V
I
D
K
D
L
A
T
S
L
L
A
K
T
L
N
S
D
Y
L
M
I
L
T
D
V
L
N
--
A
C
I
N
Y
K
K
P
D
E
R
K
L
E
E
I
K
L
S
E
I
L
A
L
E
K
D
G
H
F
A
A
G
S
M
G
P
K
V
R
A
A
I
E
F
T
Q
A
-
T
G
K
M
S
I
I
T
S
L
S
-
T
A
V
D
A
L
N
G
K
-
C
G
T
R
I
---
36
PsiBlast_CBE
90.88
41%
-81
- C5 -
4JZ8
1
?
D:
[8-314]
----
V
V
I
A
L
G
G
N
A
M
L
Q
A
K
--
E
K
G
D
Y
--
D
T
Q
R
K
N
V
E
I
A
A
S
E
I
Y
K
I
H
K
A
G
Y
K
V
V
L
T
S
G
N
G
P
Q
V
G
A
I
K
L
Q
N
---
Q
A
A
A
G
V
S
P
E
M
P
L
H
-
V
C
G
A
M
S
Q
G
F
I
G
Y
M
M
S
Q
A
M
D
N
V
F
C
A
N
N
E
P
A
N
C
V
T
C
V
T
Q
T
L
V
D
P
K
D
Q
A
F
T
N
P
T
K
P
V
G
R
F
Y
T
E
Q
E
---
A
K
---------
D
L
M
A
A
N
P
G
K
---
I
L
R
E
D
A
G
R
G
W
R
V
V
V
P
S
P
R
P
L
E
I
V
E
---
Y
G
V
I
K
T
L
I
D
N
N
V
L
V
I
C
T
N
G
G
G
I
P
-
C
K
R
E
-
N
K
V
I
S
G
V
D
A
V
I
D
K
D
L
A
T
S
L
L
A
K
T
L
N
S
D
Y
L
M
I
L
T
D
V
L
N
--
A
C
I
N
-----
E
R
K
L
E
E
I
K
L
S
E
I
L
A
L
E
K
D
G
H
F
A
A
G
S
M
G
P
K
V
R
A
A
I
E
F
T
Q
A
-
T
G
K
M
S
I
I
T
S
L
S
-
T
A
V
D
A
L
N
G
K
-
C
G
T
R
I
---
39
PsiBlast_CBE
90.59
41%
-87
- C5 -
4JZ7
1
?
D:
[8-314]
----
V
V
I
A
L
G
G
N
A
M
L
Q
A
K
--
E
K
G
D
Y
--
D
T
Q
R
K
N
V
E
I
A
A
S
E
I
Y
K
I
H
K
A
G
Y
K
V
V
L
T
S
G
N
G
P
Q
V
G
A
I
K
L
Q
N
---
Q
A
A
A
G
V
S
P
E
M
P
L
H
-
V
C
G
A
M
S
Q
G
F
I
G
Y
M
M
S
Q
A
M
D
N
V
F
C
A
N
N
E
P
A
N
C
V
T
C
V
T
Q
T
L
V
D
P
K
D
Q
A
F
T
N
P
T
K
P
V
G
R
F
Y
T
E
Q
E
---
A
K
---------
D
L
M
A
A
N
P
G
K
---
I
L
R
E
D
A
G
R
G
W
R
V
V
V
P
S
P
R
P
L
E
I
V
E
---
Y
G
V
I
K
T
L
I
D
N
N
V
L
V
I
C
T
N
G
G
G
I
P
-
C
K
R
E
-
N
K
V
I
S
G
V
D
A
V
I
D
K
D
L
A
T
S
L
L
A
K
T
L
N
S
D
Y
L
M
I
L
T
D
V
L
N
--
A
C
I
N
Y
K
K
P
D
E
R
K
L
E
E
I
K
L
S
E
I
L
A
L
E
K
D
G
H
F
A
A
G
S
M
G
P
K
V
R
A
A
I
E
F
T
Q
A
-
T
G
K
M
S
I
I
T
S
L
S
-
T
A
V
D
A
L
N
G
K
-
C
G
T
R
I
---
32
PsiBlast_CBE
90.58
41%
-83
- C5 -
4OLC
2
?
B:
[8-314]
----
V
V
I
A
L
G
G
N
A
M
L
Q
A
K
--
E
K
G
D
Y
--
D
T
Q
R
K
N
V
E
I
A
A
S
E
I
Y
K
I
H
K
A
G
Y
K
V
V
L
T
S
G
N
G
P
Q
V
G
A
I
K
L
Q
N
---
Q
A
A
A
G
V
S
P
E
M
P
L
H
-
V
C
G
A
M
S
Q
G
F
I
G
Y
M
M
S
Q
A
M
D
N
V
F
C
A
N
N
E
P
A
N
C
V
T
C
V
T
Q
T
L
V
D
P
K
D
Q
A
F
T
N
P
T
K
P
V
G
R
F
Y
T
E
Q
E
---
A
K
---------
D
L
M
A
A
N
P
G
K
---
I
L
R
E
D
A
G
R
G
W
R
V
V
V
P
S
P
R
P
L
E
I
V
E
---
Y
G
V
I
K
T
L
I
D
N
N
V
L
V
I
C
T
N
G
G
G
I
P
-
C
K
R
E
-
N
K
V
I
S
G
V
D
A
V
I
D
K
D
L
A
T
S
L
L
A
K
T
L
N
S
D
Y
L
M
I
L
T
D
V
L
N
--
A
C
I
-------
R
K
L
E
E
I
K
L
S
E
I
L
A
L
E
K
D
G
H
F
A
A
G
S
M
G
P
K
V
R
A
A
I
E
F
T
Q
A
-
T
G
K
M
S
I
I
T
S
L
S
-
T
A
V
D
A
L
N
G
K
-
C
G
T
R
I
---
7
PsiBlast_PDB
90.55
41%
-85
- C5 -
4JZ9
1
?
A:
[8-314]
----
V
V
I
A
L
G
G
N
A
M
L
Q
A
K
--
E
K
G
D
Y
--
D
T
Q
R
K
N
V
E
I
A
A
S
E
I
Y
K
I
H
K
A
G
Y
K
V
V
L
T
S
G
N
G
P
Q
V
G
A
I
K
L
Q
N
---
Q
A
A
A
G
V
S
P
E
M
P
L
H
-
V
C
G
A
M
S
Q
G
F
I
G
Y
M
M
S
Q
A
M
D
N
V
F
C
A
N
N
E
P
A
N
C
V
T
C
V
T
Q
T
L
V
D
P
K
D
Q
A
F
T
N
P
T
K
P
V
G
R
F
Y
T
E
Q
E
---
A
K
---------
D
L
M
A
A
N
P
G
K
---
I
L
R
E
D
A
G
R
G
W
R
V
V
V
P
S
P
R
P
L
E
I
V
E
---
Y
G
V
I
K
T
L
I
D
N
N
V
L
V
I
C
T
N
G
G
G
I
P
-
C
K
R
E
-
N
K
V
I
S
G
V
D
A
V
I
D
K
D
L
A
T
S
L
L
A
K
T
L
N
S
D
Y
L
M
I
L
T
D
V
L
N
--
A
C
I
N
Y
K
K
P
D
E
R
K
L
E
E
I
K
L
S
E
I
L
A
L
E
K
D
G
H
F
A
A
G
S
M
G
P
K
V
R
A
A
I
E
F
T
Q
A
-
T
G
K
M
S
I
I
T
S
L
S
-
T
A
V
D
A
L
N
G
K
-
C
G
T
R
I
---
30
PsiBlast_CBE
90.42
41%
-82
- C5 -
4OLC
1
?
D:
[8-314]
----
V
V
I
A
L
G
G
N
A
M
L
Q
A
K
--
E
K
G
D
Y
--
D
T
Q
R
K
N
V
E
I
A
A
S
E
I
Y
K
I
H
K
A
G
Y
K
V
V
L
T
S
G
N
G
P
Q
V
G
A
I
K
L
Q
N
---
Q
A
A
A
G
V
S
P
E
M
P
L
H
-
V
C
G
A
M
S
Q
G
F
I
G
Y
M
M
S
Q
A
M
D
N
V
F
C
A
N
N
E
P
A
N
C
V
T
C
V
T
Q
T
L
V
D
P
K
D
Q
A
F
T
N
P
T
K
P
V
G
R
F
Y
T
E
Q
E
---
A
K
---------
D
L
M
A
A
N
P
G
K
---
I
L
R
E
D
A
G
R
G
W
R
V
V
V
P
S
P
R
P
L
E
I
V
E
---
Y
G
V
I
K
T
L
I
D
N
N
V
L
V
I
C
T
N
G
G
G
I
P
-
C
K
R
E
-
N
K
V
I
S
G
V
D
A
V
I
D
K
D
L
A
T
S
L
L
A
K
T
L
N
S
D
Y
L
M
I
L
T
D
V
L
N
--
A
C
I
-------
R
K
L
E
E
I
K
L
S
E
I
L
A
L
E
K
D
G
H
F
A
A
G
S
M
G
P
K
V
R
A
A
I
E
F
T
Q
A
-
T
G
K
M
S
I
I
T
S
L
S
-
T
A
V
D
A
L
N
G
K
-
C
G
T
R
I
---
6
PsiBlast_PDB
90.38
41%
-82
- C5 -
4JZ8
1
?
A:
[8-314]
----
V
V
I
A
L
G
G
N
A
M
L
Q
A
K
--
E
K
G
D
Y
--
D
T
Q
R
K
N
V
E
I
A
A
S
E
I
Y
K
I
H
K
A
G
Y
K
V
V
L
T
S
G
N
G
P
Q
V
G
A
I
K
L
Q
N
---
Q
A
A
A
G
V
S
P
E
M
P
L
H
-
V
C
G
A
M
S
Q
G
F
I
G
Y
M
M
S
Q
A
M
D
N
V
F
C
A
N
N
E
P
A
N
C
V
T
C
V
T
Q
T
L
V
D
P
K
D
Q
A
F
T
N
P
T
K
P
V
G
R
F
Y
T
E
Q
E
---
A
K
---------
D
L
M
A
A
N
P
G
K
---
I
L
R
E
D
A
G
R
G
W
R
V
V
V
P
S
P
R
P
L
E
I
V
E
---
Y
G
V
I
K
T
L
I
D
N
N
V
L
V
I
C
T
N
G
G
G
I
P
-
C
K
R
E
-
N
K
V
I
S
G
V
D
A
V
I
D
K
D
L
A
T
S
L
L
A
K
T
L
N
S
D
Y
L
M
I
L
T
D
V
L
N
--
A
C
I
N
Y
K
K
P
D
E
R
K
L
E
E
I
K
L
S
E
I
L
A
L
E
K
D
G
H
F
A
A
G
S
M
G
P
K
V
R
A
A
I
E
F
T
Q
A
-
T
G
K
M
S
I
I
T
S
L
S
-
T
A
V
D
A
L
N
G
K
-
C
G
T
R
I
---
37
PsiBlast_CBE
90.05
41%
-84
- C5 -
4JZ8
1
?
C:
[8-314]
----
V
V
I
A
L
G
G
N
A
M
L
Q
A
K
--
E
K
G
D
Y
--
D
T
Q
R
K
N
V
E
I
A
A
S
E
I
Y
K
I
H
K
A
G
Y
K
V
V
L
T
S
G
N
G
P
Q
V
G
A
I
K
L
Q
N
---
Q
A
A
A
G
V
S
P
E
M
P
L
H
-
V
C
G
A
M
S
Q
G
F
I
G
Y
M
M
S
Q
A
M
D
N
V
F
C
A
N
N
E
P
A
N
C
V
T
C
V
T
Q
T
L
V
D
P
K
D
Q
A
F
T
N
P
T
K
P
V
G
R
F
Y
T
E
Q
E
---
A
K
---------
D
L
M
A
A
N
P
G
K
---
I
L
R
E
D
A
G
R
G
W
R
V
V
V
P
S
P
R
P
L
E
I
V
E
---
Y
G
V
I
K
T
L
I
D
N
N
V
L
V
I
C
T
N
G
G
G
I
P
-
C
K
R
E
-
N
K
V
I
S
G
V
D
A
V
I
D
K
D
L
A
T
S
L
L
A
K
T
L
N
S
D
Y
L
M
I
L
T
D
V
L
N
--
A
C
I
N
-----
E
R
K
L
E
E
I
K
L
S
E
I
L
A
L
E
K
D
G
H
F
A
A
G
S
M
G
P
K
V
R
A
A
I
E
F
T
Q
A
-
T
G
K
M
S
I
I
T
S
L
S
-
T
A
V
D
A
L
N
G
K
-
C
G
T
R
I
---
34
PsiBlast_CBE
89.90
41%
-86
- C5 -
4JZ9
1
?
C:
[8-314]
----
V
V
I
A
L
G
G
N
A
M
L
Q
A
K
--
E
K
G
D
Y
--
D
T
Q
R
K
N
V
E
I
A
A
S
E
I
Y
K
I
H
K
A
G
Y
K
V
V
L
T
S
G
N
G
P
Q
V
G
A
I
K
L
Q
N
---
Q
A
A
A
G
V
S
P
E
M
P
L
H
-
V
C
G
A
M
S
Q
G
F
I
G
Y
M
M
S
Q
A
M
D
N
V
F
C
A
N
N
E
P
A
N
C
V
T
C
V
T
Q
T
L
V
D
P
K
D
Q
A
F
T
N
P
T
K
P
V
G
R
F
Y
T
E
Q
E
---
A
K
---------
D
L
M
A
A
N
P
G
K
---
I
L
R
E
D
A
G
R
G
W
R
V
V
V
P
S
P
R
P
L
E
I
V
E
---
Y
G
V
I
K
T
L
I
D
N
N
V
L
V
I
C
T
N
G
G
G
I
P
-
C
K
R
E
-
N
K
V
I
S
G
V
D
A
V
I
D
K
D
L
A
T
S
L
L
A
K
T
L
N
S
D
Y
L
M
I
L
T
D
V
L
N
--
A
C
I
N
Y
K
K
P
D
E
R
K
L
E
E
I
K
L
S
E
I
L
A
L
E
K
D
G
H
F
A
A
G
S
M
G
P
K
V
R
A
A
I
E
F
T
Q
A
-
T
G
K
M
S
I
I
T
S
L
S
-
T
A
V
D
A
L
N
G
K
-
C
G
T
R
I
---
31
PsiBlast_CBE
89.45
41%
-86
- C5 -
4OLC
2
?
C:
[8-314]
----
V
V
I
A
L
G
G
N
A
M
L
Q
A
K
--
E
K
G
D
Y
--
D
T
Q
R
K
N
V
E
I
A
A
S
E
I
Y
K
I
H
K
A
G
Y
K
V
V
L
T
S
G
N
G
P
Q
V
G
A
I
K
L
Q
N
---
Q
A
A
A
G
V
S
P
E
M
P
L
H
-
V
C
G
A
M
S
Q
G
F
I
G
Y
M
M
S
Q
A
M
D
N
V
F
C
A
N
N
E
P
A
N
C
V
T
C
V
T
Q
T
L
V
D
P
K
D
Q
A
F
T
N
P
T
K
P
V
G
R
F
Y
T
E
Q
E
---
A
K
---------
D
L
M
A
A
N
P
G
K
---
I
L
R
E
D
A
G
R
G
W
R
V
V
V
P
S
P
R
P
L
E
I
V
E
---
Y
G
V
I
K
T
L
I
D
N
N
V
L
V
I
C
T
N
G
G
G
I
P
-
C
K
R
E
-
N
K
V
I
S
G
V
D
A
V
I
D
K
D
L
A
T
S
L
L
A
K
T
L
N
S
D
Y
L
M
I
L
T
D
V
L
N
--
A
C
I
-------
R
K
L
E
E
I
K
L
S
E
I
L
A
L
E
K
D
G
H
F
A
A
G
S
M
G
P
K
V
R
A
A
I
E
F
T
Q
A
-
T
G
K
M
S
I
I
T
S
L
S
-
T
A
V
D
A
L
N
G
K
-
C
G
T
R
I
---
40
PsiBlast_CBE
89.28
41%
-85
- C5 -
4JZ7
1
?
C:
[8-314]
----
V
V
I
A
L
G
G
N
A
M
L
Q
A
K
--
E
K
G
D
Y
--
D
T
Q
R
K
N
V
E
I
A
A
S
E
I
Y
K
I
H
K
A
G
Y
K
V
V
L
T
S
G
N
G
P
Q
V
G
A
I
K
L
Q
N
---
Q
A
A
A
G
V
S
P
E
M
P
L
H
-
V
C
G
A
M
S
Q
G
F
I
G
Y
M
M
S
Q
A
M
D
N
V
F
C
A
N
N
E
P
A
N
C
V
T
C
V
T
Q
T
L
V
D
P
K
D
Q
A
F
T
N
P
T
K
P
V
G
R
F
Y
T
E
Q
E
---
A
K
---------
D
L
M
A
A
N
P
G
K
---
I
L
R
E
D
A
G
R
G
W
R
V
V
V
P
S
P
R
P
L
E
I
V
E
---
Y
G
V
I
K
T
L
I
D
N
N
V
L
V
I
C
T
N
G
G
G
I
P
-
C
K
R
E
-
N
K
V
I
S
G
V
D
A
V
I
D
K
D
L
A
T
S
L
L
A
K
T
L
N
S
D
Y
L
M
I
L
T
D
V
L
N
--
A
C
I
N
Y
K
K
P
D
E
R
K
L
E
E
I
K
L
S
E
I
L
A
L
E
K
D
G
H
F
A
A
G
S
M
G
P
K
V
R
A
A
I
E
F
T
Q
A
-
T
G
K
M
S
I
I
T
S
L
S
-
T
A
V
D
A
L
N
G
K
-
C
G
T
R
I
---
44
PsiBlast_CBE
86.51
41%
-84
- C5 -
3KZF
1
?
B:
[8-314]
----
V
V
I
A
L
G
G
N
A
M
L
Q
A
K
--
E
K
G
D
Y
--
D
T
Q
R
K
N
V
E
I
A
A
S
E
I
Y
K
I
H
K
A
G
Y
K
V
V
L
T
S
G
N
G
P
Q
V
G
A
I
K
L
Q
N
---
Q
A
A
A
G
V
S
P
E
M
P
L
H
-
V
C
G
A
M
S
Q
G
F
I
G
Y
M
M
S
Q
A
M
D
N
V
F
C
A
N
N
E
P
A
N
C
V
T
C
V
T
Q
T
L
V
D
P
K
D
Q
A
F
T
N
P
T
K
P
V
G
R
F
Y
T
E
----------------------------
I
L
R
E
D
A
G
R
G
W
R
V
V
V
P
S
P
R
P
L
E
I
V
E
---
Y
G
V
I
K
T
L
I
D
N
N
V
L
V
I
C
T
N
G
G
G
I
P
-
C
K
R
E
-
N
K
V
I
S
G
V
D
A
V
I
D
K
D
L
A
T
S
L
L
A
K
T
L
N
S
D
Y
L
M
I
L
T
D
V
L
N
--
A
C
I
--
K
K
P
D
E
R
K
L
E
E
I
K
L
S
E
I
L
A
L
E
K
D
G
H
F
--
G
S
M
G
P
K
V
R
A
A
I
E
F
T
Q
A
-
T
G
K
M
S
I
I
T
S
L
S
-
T
A
V
D
A
L
N
G
K
-
C
G
T
R
I
---
46
HHSearch
86.20
42%
-79
- C5 -
1E19
1
CPKA_PYRFU
A:
[2-314]
-
G
K
R
V
V
I
A
L
G
G
N
A
-
L
Q
Q
R
--
G
-
Q
K
G
S
Y
E
E
M
M
D
N
V
R
K
T
A
R
Q
I
A
E
I
I
A
R
G
Y
E
V
V
I
T
H
G
N
G
P
Q
V
G
S
L
L
L
H
M
-
D
A
G
Q
A
T
Y
G
I
P
A
Q
P
M
D
-
V
A
G
A
M
S
Q
G
W
I
G
Y
M
I
Q
Q
A
L
K
N
E
L
R
K
R
G
M
E
K
K
V
V
T
I
I
T
Q
T
I
V
D
K
N
D
P
A
F
Q
N
P
T
K
P
V
G
P
F
Y
D
E
E
T
---
A
K
R
L
A
R
E
KG
W
I
V
K
E
D
S
G
R
G
W
---
R
R
V
----------
V
P
S
P
D
P
K
G
H
V
E
---
A
E
T
I
K
K
L
V
E
R
G
V
I
V
I
A
S
G
G
G
G
V
P
-
V
I
L
E
-
D
G
E
I
K
G
V
E
A
V
I
D
K
D
L
A
G
E
K
L
A
E
E
V
N
A
D
I
F
M
I
L
T
D
V
N
G
A
A
L
Y
Y
G
T
E
--
K
E
Q
W
L
R
E
V
K
V
E
E
L
R
K
Y
Y
E
E
G
H
F
K
A
G
S
M
G
P
K
V
L
A
A
I
R
F
I
E
W
G
G
-
E
R
A
I
I
A
H
L
E
-
K
A
V
E
A
L
E
G
K
-
T
G
T
Q
V
L
P
-
5
PsiBlast_PDB
85.08
41%
-97
- C5 -
4JZ7
1
?
A:
[8-314]
----
V
V
I
A
L
G
G
N
A
M
L
Q
A
K
--
E
K
G
D
Y
--
D
T
Q
R
K
N
V
E
I
A
A
S
E
I
Y
K
I
H
K
A
G
Y
K
V
V
L
T
S
G
N
G
P
Q
V
G
A
I
K
L
Q
N
---
Q
A
A
A
G
V
S
P
E
M
P
L
H
-
V
C
G
A
M
S
Q
G
F
I
G
Y
M
M
S
Q
A
M
D
N
V
F
C
A
N
N
E
P
A
N
C
V
T
C
V
T
Q
T
L
V
D
P
K
D
Q
A
F
T
N
P
T
K
P
V
----------------------------------------------
V
V
P
S
P
R
P
L
E
I
V
E
---
Y
G
V
I
K
T
L
I
D
N
N
V
L
V
I
C
T
N
G
G
G
I
P
-
C
K
R
E
-
N
K
V
I
S
G
V
D
A
V
I
D
K
D
L
A
T
S
L
L
A
K
T
L
N
S
D
Y
L
M
I
L
T
D
V
L
N
--
A
C
I
N
Y
K
K
P
D
E
R
K
L
E
E
I
K
L
S
E
I
L
A
L
E
K
D
G
H
F
A
A
G
S
M
G
P
K
V
R
A
A
I
E
F
T
Q
A
-
T
G
K
M
S
I
I
T
S
L
S
-
T
A
V
D
A
L
N
G
K
-
C
G
T
R
I
---
41
PsiBlast_CBE
84.77
41%
-90
- C5 -
4JZ7
1
?
B:
[8-314]
----
V
V
I
A
L
G
G
N
A
M
L
Q
A
K
--
E
K
G
D
Y
--
D
T
Q
R
K
N
V
E
I
A
A
S
E
I
Y
K
I
H
K
A
G
Y
K
V
V
L
T
S
G
N
G
P
Q
V
G
A
I
K
L
Q
N
---
Q
A
A
A
G
V
S
P
E
M
P
L
H
-
V
C
G
A
M
S
Q
G
F
I
G
Y
M
M
S
Q
A
M
D
N
V
F
C
A
N
N
E
P
A
N
C
V
T
C
V
T
Q
T
L
V
D
P
K
D
Q
A
F
T
N
P
T
K
P
V
----------------------------------------------
V
V
P
S
P
R
P
L
E
I
V
E
---
Y
G
V
I
K
T
L
I
D
N
N
V
L
V
I
C
T
N
G
G
G
I
P
-
C
K
R
E
-
N
K
V
I
S
G
V
D
A
V
I
D
K
D
L
A
T
S
L
L
A
K
T
L
N
S
D
Y
L
M
I
L
T
D
V
L
N
--
A
C
I
N
Y
K
K
P
D
E
R
K
L
E
E
I
K
L
S
E
I
L
A
L
E
K
D
G
H
F
A
A
G
S
M
G
P
K
V
R
A
A
I
E
F
T
Q
A
-
T
G
K
M
S
I
I
T
S
L
S
-
T
A
V
D
A
L
N
G
K
-
C
G
T
R
I
---
45
HHSearch
84.67
44%
-80
- C5 -
2WE5
2
ARCC1_ENTFA
A:
[2-310]
-
G
K
K
M
V
V
A
L
G
G
N
A
-
I
L
S
N
--
D
-
A
S
A
--
H
A
Q
Q
Q
A
L
V
Q
T
S
A
Y
L
V
H
L
I
K
Q
G
H
R
L
I
V
S
H
G
N
G
P
Q
V
G
N
L
L
L
Q
Q
-
Q
A
A
D
S
E
-
K
N
P
A
M
P
L
D
T
C
V
A
M
T
-
Q
G
S
I
G
Y
W
L
S
N
A
L
N
Q
E
L
N
K
A
G
I
K
K
Q
V
A
T
V
L
T
Q
V
V
V
D
P
A
D
E
A
F
K
N
P
T
K
P
I
G
P
F
L
T
E
A
E
A
K
E
A
M
Q
A
G
A
I
----
F
K
E
D
A
G
R
G
W
R
K
V
V
P
S
----------------
P
K
P
I
D
IHE
A
E
T
I
N
T
L
I
K
N
D
I
I
T
I
S
C
G
G
G
G
I
P
V
V
G
Q
E
L
K
G
V
E
A
V
----
I
D
K
D
F
A
S
E
K
L
A
E
L
V
D
A
D
A
L
V
I
L
T
G
V
D
Y
--
V
C
I
N
Y
G
K
P
D
E
K
Q
L
T
N
V
T
V
A
E
L
E
E
Y
K
Q
A
G
H
F
A
P
G
S
M
L
P
K
I
E
A
A
I
Q
F
V
E
S
Q
P
-
N
K
Q
A
I
I
T
S
L
E
N
L
G
S
M
S
G
D
E
I
V
G
T
V
V
T
K
-
42
PsiBlast_CBE
84.64
41%
-86
- C5 -
3KZF
1
?
D:
[8-314]
----
V
V
I
A
L
G
G
N
A
M
L
Q
A
K
--
E
K
G
D
Y
--
D
T
Q
R
K
N
V
E
I
A
A
S
E
I
Y
K
I
H
K
A
G
Y
K
V
V
L
T
S
G
N
G
P
Q
V
G
A
I
K
L
Q
N
---
Q
A
A
A
G
V
S
P
E
M
P
L
H
-
V
C
G
A
M
S
Q
G
F
I
G
Y
M
M
S
Q
A
M
D
N
V
F
C
A
N
N
E
P
A
N
C
V
T
C
V
T
Q
T
L
V
D
P
K
D
Q
A
F
T
N
P
T
K
P
V
G
R
F
Y
T
E
----------------------------
I
L
R
E
D
A
G
R
G
W
R
V
V
V
P
S
P
R
P
L
E
I
V
E
---
Y
G
V
I
K
T
L
I
D
N
N
V
L
V
I
C
T
N
G
G
G
I
P
-
C
K
R
E
-
N
K
V
I
S
G
V
D
A
V
I
D
K
D
L
A
T
S
L
L
A
K
T
L
N
S
D
Y
L
M
I
L
T
D
V
L
N
--
A
C
-------
E
R
K
L
E
E
I
K
L
S
E
I
L
A
L
E
K
D
G
H
F
--
G
S
M
G
P
K
V
R
A
A
I
E
F
T
Q
A
-
T
G
K
M
S
I
I
T
S
L
S
-
T
A
V
D
A
L
N
G
K
-
C
G
T
R
I
---
43
PsiBlast_CBE
81.70
41%
-89
- C5 -
3KZF
1
?
C:
[8-314]
----
V
V
I
A
L
G
G
N
A
M
L
Q
A
K
--
E
K
G
D
Y
--
D
T
Q
R
K
N
V
E
I
A
A
S
E
I
Y
K
I
H
K
A
G
Y
K
V
V
L
T
S
G
N
G
P
Q
V
G
A
I
K
L
Q
N
---
Q
A
A
A
G
V
S
P
E
M
P
L
H
-
V
C
G
A
M
S
Q
G
F
I
G
Y
M
M
S
Q
A
M
D
N
V
F
C
A
N
N
E
P
A
N
C
V
T
C
V
T
Q
T
L
V
D
P
K
D
Q
A
F
T
N
P
T
K
P
V
G
R
F
Y
---------------------------------------
W
R
V
V
V
P
S
P
R
P
L
E
I
V
E
---
Y
G
V
I
K
T
L
I
D
N
N
V
L
V
I
C
T
N
G
G
G
I
P
-
C
K
R
E
-
N
K
V
I
S
G
V
D
A
V
I
D
K
D
L
A
T
S
L
L
A
K
T
L
N
S
D
Y
L
M
I
L
T
D
V
L
N
--
A
C
I
N
Y
K
----
R
K
L
E
E
I
K
L
S
E
I
L
A
L
E
K
D
G
H
F
A
A
G
S
M
G
P
K
V
R
A
A
I
E
F
T
Q
A
-
T
G
K
M
S
I
I
T
S
L
S
-
T
A
V
D
A
L
N
G
K
-
C
G
T
R
I
---