@TOME V2.3
(Nov 2016)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : SA2500: (2016-04-04 )
MVQEYDVIVIGAGHAGVEAGLASARRGAKTLMLTINLDNIAFMPCNPSVGGPAKGIVVREIDALGGQMAKTIDKTHIQMRMLNTGKGPAVRALRAQADKVLYQQEMKRVIEDEENLHIMQGMVDELIIEDNEVKGVRTNIGTEYLSKAVIITTGTFLRGEIILGNMKYSSGPNHQLPSITLSDNLRELGFDIVRFKTGTPPRVNSKTIDYSKTEIQPGDDVGRAFSFETTEYILDQLPCWLTYTNAETHKVIDDNLHLSAMYSGMIKGTGPRYCPSIEDKFVRFNDKPRHQLFLEPEGRNTNEVYVQGLSTSLPEHVQRQMLETIPGLEKADMMRAGYAIEYDAIVPTQLWPTLETKMIKNLYTAGQINGTSGYEEAAGQGLMAGINAAGKVLNTGEKILSRSDAYIGVLIDDLVTKGTNEPYRLLTSRAEYRLLLRHDNADLRLTDMGYELGMISEERYARFNEKRQQIDAEIKRLSDIRIKPNEHTQAIIEQHGGSRLKDGILAIDLLRRPEMTYDIILEILEEEHQLNADVEEQVEIQTKYEGYINKSLQQVEKVKRMEEKKIPEDLDYSKIDSLATEAREKLSEVKPLNIAQASRISGVNPADISILLIYLEQGKLQRVSD
Atome Classification :
(20 SA)
....-.....10........20........30..-......40----------...------.....50..----......60........70.....----...80........90........100.--------......110.-----......120.......130.......140.......150.......160.......170.-.....-.180......-..190.........200.......210.......220---.....-..230-.-...----...-..240....-...250..---.....260.......270.......280-----....-------------....290.......300.....-..310----........320....-----...330.......340....-...350.......360.......370.------......380.......390...----....400.......410.......420.......430.......440.......450......--.460.......470.......480.......490.......500.......510.......520----......------.-530..--......540.......550.......560.......570.......580.......590.......600.......610.......620...
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
M
V
Q
E
-
Y
D
V
I
V
I
GAGH
A
G
V
E
A
G
L
A
S
ARRG
A
K
T
L
M
L
-
T
I
NLD
N
I
A
----------
F
MP------CNPSVGGPA----K
G
I
V
V
R
E
I
D
A
LG
G
Q
M
A
K
T
I
D
K
T
H
----
I
Q
M
R
M
LNTGK
G
P
A
V
R
A
L
R
A
Q
A
D
K
V
L
Y
Q
--------
Q
E
M
K
R
V
IEDE-----EN
L
H
I
M
Q
G
M
V
D
E
L
IIEDNEVKGVRTNI
G
T
E
Y
LS
K
A
V
I
I
TTG
T
F
L
R
G
E
I
I
L
GNMKYSSGPN-HQL
P
S
-
I
T-LSD
N
L
R
E
-LG
F
--
D
I
V
R
FKTGTPPRVNSKTIDYSKTEIQPGDDVG---RAFSF-
E
T
T
---
E
-
Y
I
L
----DQL-P
C
W
L
T
YTNA-E
T
H
K
VIDD---NL
H
L
S
A
M
Y
S
G
M
IKGTGPRYCPSIE
D
K
F
------
V
RFN-------------DKPR
H
Q
L
F
LEPEGRNT
N
E
V
Y
V
Q-GLST-----S
L
P
E
H
V
Q
R
Q
M
L
E
TIP-----GL
E
K
A
D
M
M
RAG
Y
A
I
E
Y
DAIV-P
T
Q
LWP
T
L
E
T
K
M
I
K
N
L
YTAGQINGTSG------
Y
E
E
A
AG
Q
G
L
M
A
G
I
N
A
A
G
K
V
L
NT----
G
E
K
I
L
SRSD
A
Y
I
G
V
L
I
D
D
L
V
TKGTN
E
P
Y
R
L
L
TSRA
E
Y
R
L
L
L
R
HDNA
D
L
R
L
T
DMGYELGMI
S
E
E
--
R
Y
A
R
F
N
E
K
R
Q
Q
I
D
A
E
I
K
R
L
S
D
I
RIKP
N
E
H
T
Q
A
I
I
E
QHGG
S
R
LKDG
I
L
A
I
D
L
LRRPEM
T
Y
D
I
I
L
E
----
I
L
E
E
E
H
------Q-L-NAD--
V
E
E
Q
V
E
I
Q
T
K
Y
E
G
Y
I
N
K
S
L
Q
Q
V
E
K
V
K
R
M
E
E
KKIPEDL
D
Y
S
K
I
D
S
L
A
T
E
A
R
E
K
L
S
EVKPLN
I
A
Q
A
SRISGVNPA
D
I
S
I
L
L
I
Y
LEQGKLQRVSD
3
PsiBlast_PDB
91.31
51%
-65
- C5 -
2ZXH
3
MNMG_AQUAE
A:
[26-636]
--
D
E
-
F
D
V
V
V
I
G
G
G
H
A
G
I
E
A
A
L
A
A
A
R
M
G
A
K
T
A
M
F
-
V
L
N
A
D
T
I
G
----------
Q
M
S
------
C
N
P
A
I
G
G
I
A
----
K
G
I
V
V
R
E
I
D
A
L
G
G
E
M
G
K
A
I
D
Q
T
G
----
I
Q
F
K
M
L
N
T
R
K
G
K
A
V
Q
S
P
R
A
Q
A
D
K
K
R
Y
R
--------
E
Y
M
K
K
V
C
E
N
Q
-----
E
N
L
Y
I
K
Q
E
E
V
V
D
I
I
V
K
N
N
Q
V
V
G
V
R
T
N
L
G
V
E
Y
K
T
K
A
V
V
V
T
T
G
T
F
L
N
G
V
I
Y
I
G
D
K
M
I
P
G
G
R
L
-
G
E
P
R
S
-
E
G
-
L
S
D
F
Y
R
R
-
F
D
F
--
P
L
I
R
F
K
T
G
T
P
A
R
L
D
K
R
T
I
D
F
S
A
L
E
V
A
P
G
D
D
P
P
---
P
K
F
S
F
-
W
T
E
PVG
S
-
Y
W
F
PKG
K
E
Q
V
-
N
C
W
I
T
Y
T
T
P
-
K
T
H
E
I
I
R
K
---
N
L
H
R
T
A
L
Y
G
G
L
I
K
G
I
G
P
R
Y
C
P
S
I
E
D
K
I
------
V
K
F
P
-------------
D
K
E
R
H
Q
I
F
L
E
P
E
G
L
D
T
I
E
I
Y
P
N
-
G
L
S
T
-----
S
L
P
E
E
V
Q
W
E
M
Y
R
S
I
P
-----
G
L
E
N
V
V
L
I
R
P
A
Y
A
I
E
Y
D
V
V
P
-
P
T
E
L
Y
P
T
L
E
T
K
K
I
R
G
L
F
H
A
G
N
F
N
G
T
T
G
------
Y
E
E
A
A
G
Q
G
I
V
A
G
I
N
A
A
L
R
A
F
G
K
----
E
P
I
Y
L
R
R
D
E
S
Y
I
G
V
M
I
D
D
L
T
T
K
G
V
T
E
P
Y
R
L
F
T
S
R
S
E
Y
R
L
Y
I
R
Q
D
N
A
I
L
R
L
A
K
L
G
R
E
L
G
L
L
S
E
E
--
Q
Y
K
L
V
K
E
L
E
R
E
I
E
K
W
K
E
F
Y
K
S
E
R
V
----------------
R
S
----
Y
S
V
A
T
L
M
T
M
N
Y
T
L
D
D
V
K
E
----
K
F
G
Y
E
V
------
P
-
Q
-
H
P
Y
--
V
K
E
E
V
E
I
Q
L
K
Y
E
P
Y
I
E
R
E
R
K
L
N
E
K
L
K
K
L
E
D
T
K
I
P
P
D
I
D
Y
D
K
I
P
G
L
T
K
E
A
R
E
K
L
K
K
F
K
P
I
T
V
G
Q
A
S
R
I
D
G
I
T
P
A
A
I
T
A
L
L
V
Y
L
--
G
K
L
-----
24
PsiBlast_CBE
91.28
51%
-66
- C5 -
2ZXH
4
MNMG_AQUAE
B:
[26-634]
--
D
E
-
F
D
V
V
V
I
G
G
G
H
A
G
I
E
A
A
L
A
A
A
R
M
G
A
K
T
A
M
F
-
V
L
N
A
D
T
I
G
----------
Q
M
S
------
C
N
P
A
I
G
G
I
A
----
K
G
I
V
V
R
E
I
D
A
L
G
G
E
M
G
K
A
I
D
Q
T
G
----
I
Q
F
K
M
L
N
T
R
K
G
K
A
V
Q
S
P
R
A
Q
A
D
K
K
R
Y
R
--------
E
Y
M
K
K
V
C
E
N
Q
-----
E
N
L
Y
I
K
Q
E
E
V
V
D
I
I
V
K
N
N
Q
V
V
G
V
R
T
N
L
G
V
E
Y
K
T
K
A
V
V
V
T
T
G
T
F
L
N
G
V
I
Y
I
G
D
K
M
I
P
G
G
R
L
-
G
E
P
R
S
-
E
G
-
L
S
D
F
Y
R
R
-
F
D
F
--
P
L
I
R
F
K
T
G
T
P
A
R
L
D
K
R
T
I
D
F
S
A
L
E
V
A
P
G
D
D
P
P
---
P
K
F
S
F
-
W
T
E
PVG
S
-
Y
W
F
PKGK
E
Q
V
-
N
C
W
I
T
Y
T
T
P
-
K
T
H
E
I
I
R
K
---
N
L
H
R
T
A
L
Y
G
G
L
I
K
G
I
G
P
R
Y
C
P
S
I
E
D
K
I
------
V
K
F
P
-------------
D
K
E
R
H
Q
I
F
L
E
P
E
G
L
D
T
I
E
I
Y
P
N
-
G
L
S
T
-----
S
L
P
E
E
V
Q
W
E
M
Y
R
S
I
P
-----
G
L
E
N
V
V
L
I
R
P
A
Y
A
I
E
Y
D
V
V
P
-
P
T
E
L
Y
P
T
L
E
T
K
K
I
R
G
L
F
H
A
G
N
F
N
G
T
T
G
------
Y
E
E
A
A
G
Q
G
I
V
A
G
I
N
A
A
L
R
A
F
G
K
----
E
P
I
Y
L
R
R
D
E
S
Y
I
G
V
M
I
D
D
L
T
T
K
G
V
T
E
P
Y
R
L
F
T
S
R
S
E
Y
R
L
Y
I
R
Q
D
N
A
I
L
R
L
A
K
L
G
R
E
L
G
L
L
S
E
E
--
Q
Y
K
L
V
K
E
L
E
R
E
I
E
K
W
K
E
F
Y
K
S
E
R
V
----------------
R
S
----
Y
S
V
A
T
L
M
T
M
N
Y
T
L
D
D
V
K
E
----
K
F
G
Y
E
V
------
P
-
Q
-
H
P
Y
--
V
K
E
E
V
E
I
Q
L
K
Y
E
P
Y
I
E
R
E
R
K
L
N
E
K
L
K
K
L
E
D
T
K
I
P
P
D
I
D
Y
D
K
I
P
G
L
T
K
E
A
R
E
K
L
K
K
F
K
P
I
T
V
G
Q
A
S
R
I
D
G
I
T
P
A
A
I
T
A
L
L
V
Y
L
--
G
-------
22
PsiBlast_CBE
90.90
51%
-64
- C5 -
2ZXI
1
MNMG_AQUAE
C:
[24-635]
V
V
D
E
-
F
D
V
V
V
I
G
G
G
H
A
G
I
E
A
A
L
A
A
A
R
M
G
A
K
T
A
M
F
-
V
L
N
A
D
T
I
G
----------
Q
M
S
------
C
N
P
A
I
G
G
I
A
----
K
G
I
V
V
R
E
I
D
A
L
G
G
E
M
G
K
A
I
D
Q
T
G
----
I
Q
F
K
M
L
N
T
R
K
G
K
A
V
Q
S
P
R
A
Q
A
D
K
K
R
Y
R
--------
E
Y
M
K
K
V
C
E
N
Q
-----
E
N
L
Y
I
K
Q
E
E
V
V
D
I
I
V
K
N
N
Q
V
V
G
V
R
T
N
L
G
V
E
Y
K
T
K
A
V
V
V
T
T
G
T
F
L
N
G
V
I
Y
I
G
D
K
M
I
P
G
G
R
L
-
G
E
P
R
S
-
E
G
-
L
S
D
F
Y
R
R
-
F
D
F
--
P
L
I
R
F
K
T
G
T
P
A
R
L
D
K
R
T
I
D
F
S
A
L
E
V
A
P
G
D
D
P
P
---
P
K
F
S
F
-
W
T
E
PVG
S
-
Y
W
F
PKGK
E
Q
V
-
N
C
W
I
T
Y
T
T
P
-
K
T
H
E
I
I
R
K
---
N
L
H
R
T
A
-----------
R
Y
C
P
S
I
E
D
K
I
------
V
K
F
P
-------------
D
K
E
R
H
Q
I
F
L
E
P
E
G
L
D
T
I
E
I
Y
P
N
-
G
L
S
T
-----
S
L
P
E
E
V
Q
W
E
M
Y
R
S
I
P
-----
G
L
E
N
V
V
L
I
R
P
A
Y
A
I
E
Y
D
V
V
P
-
P
T
E
L
Y
P
T
L
E
T
K
K
I
R
G
L
F
H
A
G
N
F
N
G
T
T
G
------
Y
E
E
A
A
G
Q
G
I
V
A
G
I
N
A
A
L
R
A
F
G
K
----
E
P
I
Y
L
R
R
D
E
S
Y
I
G
V
M
I
D
D
L
T
T
K
G
V
T
E
P
Y
R
L
F
T
S
R
S
E
Y
R
L
Y
I
R
Q
D
N
A
I
L
R
L
A
K
L
G
R
E
L
G
L
L
S
E
E
--
Q
Y
K
L
V
K
E
L
E
R
E
I
E
K
W
K
E
F
Y
K
S
E
R
V
S
--------
V
A
V
G
--
T
R
S
----
Y
S
V
A
T
L
M
T
M
N
Y
T
L
D
D
V
K
E
----
K
F
G
Y
E
V
------
P
-
Q
-
H
P
Y
--
V
K
E
E
V
E
I
Q
L
K
Y
E
P
Y
I
E
R
E
R
K
L
N
E
K
L
K
K
L
E
D
T
K
I
P
P
D
I
D
Y
D
K
I
P
G
L
T
K
E
A
R
E
K
L
K
K
F
K
P
I
T
V
G
Q
A
S
R
I
D
G
I
T
P
A
A
I
T
A
L
L
V
Y
L
--
G
K
------
21
PsiBlast_CBE
90.66
51%
-65
- C5 -
2ZXI
1
MNMG_AQUAE
D:
[24-635]
V
V
D
E
-
F
D
V
V
V
I
G
G
G
H
A
G
I
E
A
A
L
A
A
A
R
M
G
A
K
T
A
M
F
-
V
L
N
A
D
T
I
G
----------
Q
M
S
------
C
N
P
A
I
G
G
I
A
----
K
G
I
V
V
R
E
I
D
A
L
G
G
E
M
G
K
A
I
D
Q
T
G
----
I
Q
F
K
M
L
N
T
R
K
G
K
A
V
Q
S
P
R
A
Q
A
D
K
K
R
Y
R
--------
E
Y
M
K
K
V
C
E
N
Q
-----
E
N
L
Y
I
K
Q
E
E
V
V
D
I
I
V
K
N
N
Q
V
V
G
V
R
T
N
L
G
V
E
Y
K
T
K
A
V
V
V
T
T
G
T
F
L
N
G
V
I
Y
I
G
D
K
M
I
P
G
G
R
L
-
G
E
P
R
S
-
E
G
-
L
S
D
F
Y
R
R
-
F
D
F
--
P
L
I
R
F
K
T
G
T
P
A
R
L
D
K
R
T
I
D
F
S
A
L
E
V
A
P
G
D
D
P
P
---
P
K
F
S
F
-
W
T
E
PVG
S
-
Y
W
F
PKGK
E
Q
V
-
N
C
W
I
T
Y
T
T
P
-
K
T
H
E
I
I
R
K
---
N
L
H
R
--------------
Y
C
P
S
I
E
D
K
I
------
V
K
F
P
-------------
D
K
E
R
H
Q
I
F
L
E
P
E
G
L
D
T
I
E
I
Y
P
N
-
G
L
S
T
-----
S
L
P
E
E
V
Q
W
E
M
Y
R
S
I
P
-----
G
L
E
N
V
V
L
I
R
P
A
Y
A
I
E
Y
D
V
V
P
-
P
T
E
L
Y
P
T
L
E
T
K
K
I
R
G
L
F
H
A
G
N
F
N
G
T
T
G
------
Y
E
E
A
A
G
Q
G
I
V
A
G
I
N
A
A
L
R
A
F
G
K
----
E
P
I
Y
L
R
R
D
E
S
Y
I
G
V
M
I
D
D
L
T
T
K
G
V
T
E
P
Y
R
L
F
T
S
R
S
E
Y
R
L
Y
I
R
Q
D
N
A
I
L
R
L
A
K
L
G
R
E
L
G
L
L
S
E
E
--
Q
Y
K
L
V
K
E
L
E
R
E
I
E
K
W
K
E
F
Y
K
S
E
R
V
S
--------
V
A
V
G
G
D
T
R
S
----
Y
S
V
A
T
L
M
T
M
N
Y
T
L
D
D
V
K
E
----
K
F
G
Y
E
V
------
P
-
Q
-
H
P
Y
--
V
K
E
E
V
E
I
Q
L
K
Y
E
P
Y
I
E
R
E
R
K
L
N
E
K
L
K
K
L
E
D
T
K
I
P
P
D
I
D
Y
D
K
I
P
G
L
T
K
E
A
R
E
K
L
K
K
F
K
P
I
T
V
G
Q
A
S
R
I
D
G
I
T
P
A
A
I
T
A
L
L
V
Y
L
--
G
K
------
23
PsiBlast_CBE
90.65
51%
-64
- C5 -
2ZXI
1
MNMG_AQUAE
B:
[24-635]
V
V
D
E
-
F
D
V
V
V
I
G
G
G
H
A
G
I
E
A
A
L
A
A
A
R
M
G
A
K
T
A
M
F
-
V
L
N
A
D
T
I
G
----------
Q
M
S
------
C
N
P
A
I
G
G
I
A
----
K
G
I
V
V
R
E
I
D
A
L
G
G
E
M
G
K
A
I
D
Q
T
G
----
I
Q
F
K
M
L
N
T
R
K
G
K
A
V
Q
S
P
R
A
Q
A
D
K
K
R
Y
R
--------
E
Y
M
K
K
V
C
E
N
Q
-----
E
N
L
Y
I
K
Q
E
E
V
V
D
I
I
V
K
N
N
Q
V
V
G
V
R
T
N
L
G
V
E
Y
K
T
K
A
V
V
V
T
T
G
T
F
L
N
G
V
I
Y
I
G
D
K
M
I
P
G
G
R
L
-
G
E
P
R
S
-
E
G
-
L
S
D
F
Y
R
R
-
F
D
F
--
P
L
I
R
F
K
T
G
T
P
A
R
L
D
K
R
T
I
D
F
S
A
L
E
V
A
P
G
D
D
P
P
---
P
K
F
S
F
-
W
T
E
PVG
S
-
Y
W
F
PKGK
E
Q
V
-
N
C
W
I
T
Y
T
T
P
-
K
T
H
E
I
I
R
K
---
N
L
H
R
T
A
-----------
R
Y
C
P
S
I
E
D
K
I
------
V
K
F
P
-------------
D
K
E
R
H
Q
I
F
L
E
P
E
G
L
D
T
I
E
I
Y
P
N
-
G
L
S
T
-----
S
L
P
E
E
V
Q
W
E
M
Y
R
S
I
P
-----
G
L
E
N
V
V
L
I
R
P
A
Y
A
I
E
Y
D
V
V
P
-
P
T
E
L
Y
P
T
L
E
T
K
K
I
R
G
L
F
H
A
G
N
F
N
G
T
T
G
------
Y
E
E
A
A
G
Q
G
I
V
A
G
I
N
A
A
L
R
A
F
G
K
----
E
P
I
Y
L
R
R
D
E
S
Y
I
G
V
M
I
D
D
L
T
T
K
G
V
T
E
P
Y
R
L
F
T
S
R
S
E
Y
R
L
Y
I
R
Q
D
N
A
I
L
R
L
A
K
L
G
R
E
L
G
L
L
S
E
E
--
Q
Y
K
L
V
K
E
L
E
R
E
I
E
K
W
K
E
F
Y
K
S
E
R
V
S
--------
V
A
V
G
G
D
T
R
S
----
Y
S
V
A
T
L
M
T
M
N
Y
T
L
D
D
V
K
E
----
K
F
G
Y
E
V
------
P
-
Q
-
H
P
Y
--
V
K
E
E
V
E
I
Q
L
K
Y
E
P
Y
I
E
R
E
R
K
L
N
E
K
L
K
K
L
E
D
T
K
I
P
P
D
I
D
Y
D
K
I
P
G
L
T
K
E
A
R
E
K
L
K
K
F
K
P
I
T
V
G
Q
A
S
R
I
D
G
I
T
P
A
A
I
T
A
L
L
V
Y
L
--
G
K
------
27
PsiBlast_CBE
89.57
46%
-70
- C5 -
3CP8
1
MNMG_CHLTE
C:
[22-639]
-----
Y
D
V
I
V
V
G
A
G
H
A
G
C
E
A
A
L
A
V
A
R
G
G
L
H
C
L
L
I
-
T
S
D
L
S
A
V
A
----------
R
M
S
------
C
N
P
A
I
G
G
V
A
----
K
G
Q
I
T
R
E
I
D
A
L
G
G
E
M
G
K
A
I
D
A
T
G
----
I
Q
F
R
M
L
N
R
S
K
G
P
A
M
H
S
P
R
A
Q
A
D
K
T
Q
Y
S
--------
L
Y
M
R
R
I
V
E
H
E
-----
P
N
I
D
L
L
Q
D
T
V
I
G
V
S
A
N
S
G
K
F
S
S
V
T
V
R
S
G
R
A
I
Q
A
K
A
A
I
L
A
C
G
T
F
L
N
G
L
I
H
I
G
M
D
H
F
P
G
G
R
S
-
T
A
E
P
P
-
V
E
G
L
T
E
S
L
A
S
-
L
G
F
--
S
F
G
R
L
K
T
G
T
P
P
R
I
D
S
R
S
V
D
Y
T
I
V
T
E
Q
P
G
D
V
D
P
---
V
P
F
S
F
-
S
S
T
---
S
-
V
A
N
----
R
N
L
V
S
C
Y
L
T
K
T
T
E
-
K
T
H
D
I
L
R
T
---
G
F
D
R
S
P
L
F
T
G
---------
C
P
S
I
E
D
K
I
------
S
R
F
P
-------------
D
K
S
S
H
H
I
F
L
E
P
E
G
T
D
T
V
E
M
Y
V
N
-
G
F
S
T
-----
S
L
P
E
D
I
Q
I
A
G
L
R
S
I
P
-----
G
L
E
E
A
K
M
I
R
P
G
Y
A
I
E
Y
D
F
F
H
-
P
W
Q
I
R
S
T
M
E
T
R
P
V
E
N
L
F
F
A
G
Q
I
N
G
T
S
G
------
Y
E
E
A
A
A
Q
G
L
M
A
G
I
N
A
V
R
K
I
L
G
K
----
E
L
I
V
L
G
R
D
Q
A
Y
I
G
V
L
I
D
D
L
I
T
K
E
T
K
E
P
Y
R
M
F
T
S
S
A
E
H
R
L
I
L
R
H
D
N
A
D
L
R
L
R
K
I
G
Y
D
C
N
L
V
S
S
D
--
D
L
H
R
T
E
S
I
I
K
R
V
Q
H
C
L
E
V
M
K
T
A
K
V
T
P
A
E
-
I
N
T
L
L
M
N
K
G
L
Q
E
L
K
T
P
A
R
A
L
S
L
I
K
R
P
G
I
S
L
Q
D
I
L
E
HSLS
V
R
S
A
A
E
------
E
-
L
-
C
N
D
PR
V
A
E
Q
V
Q
I
E
I
K
Y
E
G
Y
I
K
R
E
Q
L
V
A
D
R
I
A
R
L
D
S
L
H
I
P
D
N
F
N
Y
D
S
L
N
S
L
S
S
E
G
R
E
K
L
L
K
H
R
P
A
T
I
G
Q
A
S
R
I
L
G
V
S
P
S
D
V
S
I
L
M
I
R
L
----------
28
PsiBlast_CBE
89.17
46%
-68
- C5 -
3CP8
1
MNMG_CHLTE
B:
[22-639]
-----
Y
D
V
I
V
V
G
A
G
H
A
G
C
E
A
A
L
A
V
A
R
G
G
L
H
C
L
L
I
-
T
S
D
L
S
A
V
A
----------
R
M
S
------
C
N
P
A
I
G
G
V
A
----
K
G
Q
I
T
R
E
I
D
A
L
G
G
E
M
G
K
A
I
D
A
T
G
----
I
Q
F
R
M
L
N
R
S
K
G
P
A
M
H
S
P
R
A
Q
A
D
K
T
Q
Y
S
--------
L
Y
M
R
R
I
V
E
H
E
-----
P
N
I
D
L
L
Q
D
T
V
I
G
V
S
A
N
S
G
K
F
S
S
V
T
V
R
S
G
R
A
I
Q
A
K
A
A
I
L
A
C
G
T
F
L
N
G
L
I
H
I
G
M
D
H
F
P
G
G
R
S
-
T
A
E
P
P
-
V
E
G
L
T
E
S
L
A
S
-
L
G
F
--
S
F
G
R
L
K
T
G
T
P
P
R
I
D
S
R
S
V
D
Y
T
I
V
T
E
Q
P
G
D
V
D
P
---
V
P
F
S
F
-
S
S
T
---
S
-
V
A
N
----
R
N
L
V
S
C
Y
L
T
K
T
T
E
-
K
T
H
D
I
L
R
T
---
G
F
D
R
S
P
L
F
T
G
---------
C
P
S
I
E
D
K
I
------
S
R
F
P
-------------
D
K
S
S
H
H
I
F
L
E
P
E
G
T
D
T
V
E
M
Y
V
N
-
G
F
S
T
-----
S
L
P
E
D
I
Q
I
A
G
L
R
S
I
P
-----
G
L
E
E
A
K
M
I
R
P
G
Y
A
I
E
Y
D
F
F
H
-
P
W
Q
I
R
S
T
M
E
T
R
P
V
E
N
L
F
F
A
G
Q
I
N
G
T
S
G
------
Y
E
E
A
A
A
Q
G
L
M
A
G
I
N
A
V
R
K
I
L
G
K
----
E
L
I
V
L
G
R
D
Q
A
Y
I
G
V
L
I
D
D
L
I
T
K
E
T
K
E
P
Y
R
M
F
T
S
S
A
E
H
R
L
I
L
R
H
D
N
A
D
L
R
L
R
K
I
G
Y
D
C
N
L
V
S
S
D
--
D
L
H
R
T
E
S
I
I
K
R
V
Q
H
C
L
E
V
M
K
T
A
K
V
T
P
A
E
-
I
N
T
L
L
M
N
K
G
L
Q
E
L
K
T
P
A
R
A
L
S
L
I
K
R
P
G
I
S
L
Q
D
I
L
E
HSLS
V
R
S
A
A
E
------
E
-
L
-
C
N
D
PR
V
A
E
Q
V
Q
I
E
I
K
Y
E
G
Y
I
K
R
E
Q
L
V
A
D
R
I
A
R
L
D
S
L
H
I
P
D
N
F
N
Y
D
S
L
N
S
L
S
S
E
G
R
E
K
L
L
K
H
R
P
A
T
I
G
Q
A
S
R
I
L
G
V
S
P
S
D
V
S
I
L
M
I
R
L
----------
5
PsiBlast_PDB
89.04
46%
-68
- C5 -
3CP8
1
MNMG_CHLTE
A:
[22-639]
-----
Y
D
V
I
V
V
G
A
G
H
A
G
C
E
A
A
L
A
V
A
R
G
G
L
H
C
L
L
I
-
T
S
D
L
S
A
V
A
----------
R
M
S
------
C
N
P
A
I
G
G
V
A
----
K
G
Q
I
T
R
E
I
D
A
L
G
G
E
M
G
K
A
I
D
A
T
G
----
I
Q
F
R
M
L
N
R
S
K
G
P
A
M
H
S
P
R
A
Q
A
D
K
T
Q
Y
S
--------
L
Y
M
R
R
I
V
E
H
E
-----
P
N
I
D
L
L
Q
D
T
V
I
G
V
S
A
N
S
G
K
F
S
S
V
T
V
R
S
G
R
A
I
Q
A
K
A
A
I
L
A
C
G
T
F
L
N
G
L
I
H
I
G
M
D
H
F
P
G
G
R
S
-
T
A
E
P
P
-
V
E
G
L
T
E
S
L
A
S
-
L
G
F
--
S
F
G
R
L
K
T
G
T
P
P
R
I
D
S
R
S
V
D
Y
T
I
V
T
E
Q
P
G
D
V
D
P
---
V
P
F
S
F
-
S
S
T
---
S
-
V
A
N
----
R
N
L
V
S
C
Y
L
T
K
T
T
E
-
K
T
H
D
I
L
R
T
---
G
F
D
R
S
P
L
F
T
G
---------
C
P
S
I
E
D
K
I
------
S
R
F
P
-------------
D
K
S
S
H
H
I
F
L
E
P
E
G
T
D
T
V
E
M
Y
V
N
-
G
F
S
T
-----
S
L
P
E
D
I
Q
I
A
G
L
R
S
I
P
-----
G
L
E
E
A
K
M
I
R
P
G
Y
A
I
E
Y
D
F
F
H
-
P
W
Q
I
R
S
T
M
E
T
R
P
V
E
N
L
F
F
A
G
Q
I
N
G
T
S
G
------
Y
E
E
A
A
A
Q
G
L
M
A
G
I
N
A
V
R
K
I
L
G
K
----
E
L
I
V
L
G
R
D
Q
A
Y
I
G
V
L
I
D
D
L
I
T
K
E
T
K
E
P
Y
R
M
F
T
S
S
A
E
H
R
L
I
L
R
H
D
N
A
D
L
R
L
R
K
I
G
Y
D
C
N
L
V
S
S
D
--
D
L
H
R
T
E
S
I
I
K
R
V
Q
H
C
L
E
V
M
K
T
A
K
V
T
P
A
E
-
I
N
T
L
L
M
N
K
G
L
Q
E
L
K
T
P
A
R
A
L
S
L
I
K
R
P
G
I
S
L
Q
D
I
L
E
H
S
L
S
V
R
S
A
A
E
------
E
-
L
-
C
N
D
P
R
V
A
E
Q
V
Q
I
E
I
K
Y
E
G
Y
I
K
R
E
Q
L
V
A
D
R
I
A
R
L
D
S
L
H
I
P
D
N
F
N
Y
D
S
L
N
S
L
S
S
E
G
R
E
K
L
L
K
H
R
P
A
T
I
G
Q
A
S
R
I
L
G
V
S
P
S
D
V
S
I
L
M
I
R
L
----------
110
HHSearch
88.44
47%
-64
- C5 -
3CP8
1
MNMG_CHLTE
A:
[20-639]
--
H
M
-
Y
D
V
I
V
V
G
A
G
H
A
G
C
E
A
A
L
A
V
A
R
G
G
L
H
C
L
L
I
-
T
S
D
L
S
A
V
A
----------
R
M
S
------
C
N
P
A
I
G
G
V
A
----
K
G
Q
I
T
R
E
I
D
A
L
G
G
E
M
G
K
A
I
D
A
T
G
----
I
Q
F
R
M
L
N
R
S
K
G
P
A
M
H
S
P
R
A
Q
A
D
K
T
Q
Y
S
--------
L
Y
M
R
R
I
V
E
H
E
-----
P
N
I
D
L
L
Q
D
T
V
I
G
V
S
A
N
S
G
K
F
S
S
V
T
V
R
S
G
R
A
I
Q
A
K
A
A
I
L
A
C
G
T
F
L
N
G
L
I
H
I
G
M
D
H
F
P
G
G
R
S
T
A
E
P
P
V
-
E
G
-
L
T
E
S
L
A
S
-
L
G
F
--
S
F
G
R
L
K
T
G
T
P
P
R
I
D
S
R
S
V
D
Y
T
I
V
T
E
Q
P
G
D
V
D
P
---
V
P
F
S
F
-
S
S
T
---
S
V
A
N
R
----
N
L
V
-
S
C
Y
L
T
K
T
T
E
-
K
T
H
D
I
L
R
T
---
G
F
D
R
S
P
L
F
T
G
---------
C
P
S
I
E
D
K
I
------
S
R
F
P
-------------
D
K
S
S
H
H
I
F
L
E
P
E
G
T
D
T
V
E
M
Y
V
N
-
G
F
S
T
-----
S
L
P
E
D
I
Q
I
A
G
L
R
S
I
P
-----
G
L
E
E
A
K
M
I
R
P
G
Y
A
I
E
Y
D
F
F
H
-
P
W
Q
I
R
S
T
M
E
T
R
P
V
E
N
L
F
F
A
G
Q
I
N
G
T
S
G
------
Y
E
E
A
A
A
Q
G
L
M
A
G
I
N
A
V
R
K
I
L
G
K
----
E
L
I
V
L
G
R
D
Q
A
Y
I
G
V
L
I
D
D
L
I
T
K
E
T
K
E
P
Y
R
M
F
T
S
S
A
E
H
R
L
I
L
R
H
D
N
A
D
L
R
L
R
K
I
G
Y
D
C
N
L
V
S
S
D
--
D
L
H
R
T
E
S
I
I
K
R
V
Q
H
C
L
E
V
M
K
T
A
K
V
T
P
A
E
I
N
T
L
-
L
M
N
K
G
L
Q
E
L
K
T
P
A
R
A
L
S
L
I
K
R
P
G
I
S
L
Q
D
I
L
E
----
H
S
L
S
V
R
S
A
AE
E
L
C
-
N
-
D
P
R
--
V
A
E
Q
V
Q
I
E
I
K
Y
E
G
Y
I
K
R
E
Q
L
V
A
D
R
I
A
R
L
D
S
L
H
I
P
D
N
F
N
Y
D
S
L
N
S
L
S
S
E
G
R
E
K
L
L
K
H
R
P
A
T
I
G
Q
A
S
R
I
L
G
V
S
P
S
D
V
S
I
L
M
I
R
L
----------
26
PsiBlast_CBE
84.08
46%
-67
- C5 -
3CP8
1
MNMG_CHLTE
D:
[22-580]
-----
Y
D
V
I
V
V
G
A
G
H
A
G
C
E
A
A
L
A
V
A
R
G
G
L
H
C
L
L
I
-
T
S
D
L
S
A
V
A
----------
R
M
S
------
C
N
P
A
I
G
G
V
A
----
K
G
Q
I
T
R
E
I
D
A
L
G
G
E
M
G
K
A
I
D
A
T
G
----
I
Q
F
R
M
L
N
R
S
K
G
P
A
M
H
S
P
R
A
Q
A
D
K
T
Q
Y
S
--------
L
Y
M
R
R
I
V
E
H
E
-----
P
N
I
D
L
L
Q
D
T
V
I
G
V
S
A
N
S
G
K
F
S
S
V
T
V
R
S
G
R
A
I
Q
A
K
A
A
I
L
A
C
G
T
F
L
N
G
L
I
H
I
G
M
D
H
F
P
G
G
R
S
-
T
A
E
P
P
-
V
E
G
L
T
E
S
L
A
S
-
L
G
F
--
S
F
G
R
L
K
T
G
T
P
P
R
I
D
S
R
S
V
D
Y
T
I
V
T
E
Q
P
G
D
V
D
P
---
V
P
F
S
F
-
S
S
T
---
S
-
V
A
N
----
R
N
L
V
S
C
Y
L
T
K
T
T
E
-
K
T
H
D
I
L
R
T
---
G
F
D
R
S
P
L
F
T
G
---------
C
P
S
I
E
D
K
I
------
S
R
F
P
-------------
D
K
S
S
H
H
I
F
L
E
P
E
G
T
D
T
V
E
M
Y
V
N
-
G
F
S
T
-----
S
L
P
E
D
I
Q
I
A
G
L
R
S
I
P
-----
G
L
E
E
A
K
M
I
R
P
G
Y
A
I
E
Y
D
F
F
H
-
P
W
Q
I
R
S
T
M
E
T
R
P
V
E
N
L
F
F
A
G
Q
I
N
G
T
S
G
------
Y
E
E
A
A
A
Q
G
L
M
A
G
I
N
A
V
R
K
I
L
G
K
----
E
L
I
V
L
G
R
D
Q
A
Y
I
G
V
L
I
D
D
L
I
T
K
E
T
K
E
P
Y
R
M
F
T
S
S
A
E
H
R
L
I
L
R
H
D
N
A
D
L
R
L
R
K
I
G
Y
D
C
N
L
V
S
S
D
--
D
L
H
R
T
E
S
I
I
K
R
V
Q
H
C
L
E
V
M
K
T
A
K
V
T
P
A
E
-
I
N
T
L
L
M
N
K
G
L
Q
E
L
K
T
P
A
R
A
L
S
L
I
K
R
P
G
I
S
L
Q
D
I
L
E
HSLS
V
R
S
A
A
E
------
E
-
L
-
C
N
D
PR
V
A
E
Q
V
Q
I
E
I
K
Y
E
G
Y
I
K
R
E
Q
L
V
A
D
---------------------------------------------------------------------
108
HHSearch
82.93
51%
-68
- C5 -
3CES
-
MNMG_ECOLI
A:
[3-550]
Y
P
D
P
-
F
D
V
I
I
I
G
G
G
H
A
G
T
E
A
A
M
A
A
A
R
M
G
Q
Q
T
L
L
L
-
T
H
N
I
D
T
L
G
----------
Q
M
S
------
C
N
P
A
I
G
G
I
G
----
K
G
H
L
V
K
E
V
D
A
L
G
G
L
M
A
K
A
I
D
Q
A
G
----
I
Q
F
R
I
L
N
A
S
K
G
P
A
V
R
A
T
R
A
Q
A
D
R
V
L
Y
R
--------
Q
A
V
R
T
A
L
E
N
Q
-----
P
N
L
M
I
F
Q
Q
A
V
E
D
L
I
V
E
N
D
R
V
V
G
A
V
T
Q
M
G
L
K
F
R
A
K
A
V
V
L
T
V
G
T
F
L
D
G
K
I
H
I
G
--------------
S
-
I
P
-
L
S
R
R
L
R
E
-
L
P
L
--
R
V
G
R
L
K
T
G
T
P
P
R
I
D
A
R
T
I
D
F
S
V
L
A
Q
Q
H
G
D
N
P
M
---
P
V
F
S
F
-
M
G
N
---
A
S
Q
H
P
----
Q
Q
V
-
P
C
Y
I
T
H
T
N
E
-
K
T
H
D
V
I
R
S
---
N
L
D
R
S
---------------
P
S
I
E
D
K
V
------
M
R
F
A
-------------
D
R
N
Q
H
Q
I
F
L
E
P
E
G
L
T
S
N
E
I
Y
P
N
-
G
I
S
T
-----
S
L
P
F
D
V
Q
M
Q
I
V
R
S
M
Q
-----
G
M
E
N
A
K
I
V
R
P
G
Y
A
I
E
Y
D
F
F
D
-
P
R
D
L
K
P
T
L
E
S
K
F
I
Q
G
L
F
F
A
G
Q
I
N
G
T
T
G
------
Y
E
E
A
A
A
Q
G
L
L
A
G
L
N
A
A
R
L
S
A
D
K
----
E
G
W
A
P
A
R
S
Q
A
Y
L
G
V
L
V
D
D
L
C
T
L
G
T
K
E
P
Y
R
M
F
T
S
R
A
E
Y
R
L
M
L
R
E
D
N
A
D
L
R
L
T
E
I
G
R
E
L
G
L
V
D
D
E
--
R
W
A
R
F
N
E
K
L
E
N
I
E
R
E
R
Q
R
L
K
S
T
W
V
T
P
S
A
E
A
A
A
E
V
N
A
H
L
T
A
P
L
S
R
E
A
S
G
E
D
L
L
R
R
P
E
M
T
Y
E
K
L
T
T
----
L
T
P
F
A
P
------
A
L
T
-
D
E
Q
--
A
A
E
Q
V
E
I
Q
V
K
Y
E
G
-------------------------------------------------------------------------------
2
PsiBlast_PDB
82.76
51%
-69
- C5 -
3CES
-
MNMG_ECOLI
A:
[7-550]
-----
F
D
V
I
I
I
G
G
G
H
A
G
T
E
A
A
M
A
A
A
R
M
G
Q
Q
T
L
L
L
-
T
H
N
I
D
T
L
G
----------
Q
M
S
------
C
N
P
A
I
G
G
I
G
----
K
G
H
L
V
K
E
V
D
A
L
G
G
L
M
A
K
A
I
D
Q
A
G
----
I
Q
F
R
I
L
N
A
S
K
G
P
A
V
R
A
T
R
A
Q
A
D
R
V
L
Y
R
--------
Q
A
V
R
T
A
L
E
N
Q
-----
P
N
L
M
I
F
Q
Q
A
V
E
D
L
I
V
E
N
D
R
V
V
G
A
V
T
Q
M
G
L
K
F
R
A
K
A
V
V
L
T
V
G
T
F
L
D
G
K
I
H
I
G
--------------
S
-
I
P
-
L
S
R
R
L
R
E
-
L
P
L
--
R
V
G
R
L
K
T
G
T
P
P
R
I
D
A
R
T
I
D
F
S
V
L
A
Q
Q
H
G
D
N
P
M
---
P
V
F
S
F
M
G
N
A
---
S
-
Q
H
P
----
Q
Q
V
-
P
C
Y
I
T
H
T
N
E
-
K
T
H
D
V
I
R
S
---
N
L
D
R
S
---------------
P
S
I
E
D
K
V
------
M
R
F
A
-------------
D
R
N
Q
H
Q
I
F
L
E
P
E
G
L
T
S
N
E
I
Y
P
N
-
G
I
S
T
-----
S
L
P
F
D
V
Q
M
Q
I
V
R
S
M
Q
-----
G
M
E
N
A
K
I
V
R
P
G
Y
A
I
E
Y
D
F
F
D
-
P
R
D
L
K
P
T
L
E
S
K
F
I
Q
G
L
F
F
A
G
Q
I
N
G
T
T
G
------
Y
E
E
A
A
A
Q
G
L
L
A
G
L
N
A
A
R
L
S
A
D
K
----
E
G
W
A
P
A
R
S
Q
A
Y
L
G
V
L
V
D
D
L
C
T
L
G
T
K
E
P
Y
R
M
F
T
S
R
A
E
Y
R
L
M
L
R
E
D
N
A
D
L
R
L
T
E
I
G
R
E
L
G
L
V
D
D
E
--
R
W
A
R
F
N
E
K
L
E
N
I
E
R
E
R
Q
R
L
K
S
T
W
V
T
P
S
A
E
A
A
A
E
V
N
A
H
L
T
A
P
L
S
R
E
A
S
G
E
D
L
L
R
R
P
E
M
T
Y
E
K
L
T
T
----
L
T
P
F
A
P
------
A
-
L
T
D
E
Q
--
A
A
E
Q
V
E
I
Q
V
K
Y
E
G
-------------------------------------------------------------------------------
25
PsiBlast_CBE
81.73
52%
-63
- C5 -
3G05
3
MNMG_ECO57
B:
[33-576]
-----
F
D
V
I
I
I
G
G
G
H
A
G
T
E
A
A
M
A
A
A
R
M
G
Q
Q
T
L
L
L
-
T
H
N
I
D
T
L
G
----------
Q
M
S
------
C
N
P
A
I
G
G
I
G
----
K
G
H
L
V
K
E
V
D
A
L
G
G
L
M
A
K
A
I
D
Q
A
G
----
I
Q
F
R
I
L
N
A
S
K
G
P
A
V
R
A
T
R
A
Q
A
D
R
V
L
Y
R
--------
Q
A
V
R
T
A
L
E
N
Q
-----
P
N
L
M
I
F
Q
Q
A
V
E
D
L
I
V
E
N
D
R
V
V
G
A
V
T
Q
M
G
L
K
F
R
A
K
A
V
V
L
T
V
G
T
F
L
D
G
K
I
H
I
G
--------------
S
-
I
P
-
L
S
R
R
L
R
E
-
L
P
L
--
R
V
G
R
L
K
T
G
T
P
P
R
I
D
A
R
T
I
D
F
S
V
L
A
Q
Q
H
G
D
N
P
M
---
P
V
F
S
F
M
G
N
A
---
S
-
Q
H
P
----
Q
Q
V
-
P
C
Y
I
T
H
T
N
E
-
K
T
H
D
V
I
R
S
---
N
L
D
R
S
---------------
P
S
I
E
D
K
V
------
M
R
F
A
-------------
D
R
N
Q
H
Q
I
F
L
E
P
E
G
L
T
S
N
E
I
Y
P
N
-
G
I
S
T
-----
S
L
P
F
D
V
Q
M
Q
I
V
R
S
M
Q
-----
G
M
E
N
A
K
I
V
R
P
G
Y
A
I
E
Y
D
F
F
D
-
P
R
D
L
K
P
T
L
E
S
K
F
I
Q
G
L
F
F
A
G
Q
I
N
G
T
T
G
------
Y
E
E
A
A
A
Q
G
L
L
A
G
L
N
A
A
R
L
S
D
D
K
----
E
G
W
A
P
A
R
S
Q
A
Y
L
G
V
L
V
D
D
L
C
T
L
G
T
K
E
P
Y
R
M
F
T
S
R
A
E
Y
R
L
M
L
R
E
D
N
A
D
L
R
L
T
E
I
G
R
E
L
G
L
V
D
D
E
--
R
W
A
R
F
N
E
K
L
E
N
I
E
R
E
R
Q
R
L
K
S
T
W
V
T
P
S
A
E
A
A
A
E
V
N
A
H
L
T
A
P
L
S
R
E
A
S
G
E
D
L
L
R
R
P
E
M
T
Y
E
K
L
T
T
----
L
T
P
F
A
P
------
A
-
L
T
D
E
Q
--
A
A
E
Q
V
E
I
Q
V
K
Y
E
G
-------------------------------------------------------------------------------
4
PsiBlast_PDB
80.52
52%
-66
- C5 -
3G05
3
MNMG_ECO57
A:
[33-576]
-----
F
D
V
I
I
I
G
G
G
H
A
G
T
E
A
A
M
A
A
A
R
M
G
Q
Q
T
L
L
L
-
T
H
N
I
D
T
L
G
----------
Q
M
S
------
C
N
P
A
I
G
G
I
G
----
K
G
H
L
V
K
E
V
D
A
L
G
G
L
M
A
K
A
I
D
Q
A
G
----
I
Q
F
R
I
L
N
A
S
K
G
P
A
V
R
A
T
R
A
Q
A
D
R
V
L
Y
R
--------
Q
A
V
R
T
A
L
E
N
Q
-----
P
N
L
M
I
F
Q
Q
A
V
E
D
L
I
V
E
N
D
R
V
V
G
A
V
T
Q
M
G
L
K
F
R
A
K
A
V
V
L
T
V
G
T
F
L
D
G
K
I
H
I
G
L
D
------------
S
-
I
P
-
L
S
R
R
L
R
E
-
L
P
L
--
R
V
G
R
L
K
T
G
T
P
P
R
I
D
A
R
T
I
D
F
S
V
L
A
Q
Q
H
G
D
N
P
M
---
P
V
F
S
F
M
G
N
A
---
S
-
Q
H
P
----
Q
Q
V
-
P
C
Y
I
T
H
T
N
E
-
K
T
H
D
V
I
R
S
---
N
L
D
R
S
P
--------------
P
S
I
E
D
K
V
------
M
R
F
A
-------------
D
R
N
Q
H
Q
I
F
L
E
P
E
G
L
T
S
N
E
I
Y
P
N
-
G
I
S
T
-----
S
L
P
F
D
V
Q
M
Q
I
V
R
S
M
Q
-----
G
M
E
N
A
K
I
V
R
P
G
Y
A
I
E
Y
D
F
F
D
-
P
R
D
L
K
P
T
L
E
S
K
F
I
Q
G
L
F
F
A
G
Q
I
N
G
T
T
G
------
Y
E
E
A
A
A
Q
G
L
L
A
G
L
N
A
A
R
L
S
D
D
K
----
E
G
W
A
P
A
R
S
Q
A
Y
L
G
V
L
V
D
D
L
C
T
L
G
T
K
E
P
Y
R
M
F
T
S
R
A
E
Y
R
L
M
L
R
E
D
N
A
D
L
R
L
T
E
I
G
R
E
L
G
L
V
D
D
E
--
R
W
A
R
F
N
E
K
L
E
N
I
E
R
E
R
Q
R
L
K
S
T
W
V
T
P
S
A
E
A
A
A
E
V
N
A
H
L
T
A
P
L
S
R
E
A
S
G
E
D
L
L
R
R
P
E
M
T
Y
E
K
L
T
T
----
L
T
P
F
A
P
------
A
-
L
T
D
E
Q
--
A
A
E
Q
V
E
I
Q
V
K
Y
E
G
-------------------------------------------------------------------------------
1
PsiBlast_PDB
79.50
51%
-67
- C5 -
3CP2
1
MNMG_ECOLI
A:
[27-573]
-----
F
D
V
I
I
I
G
G
G
H
A
G
T
E
A
A
M
A
A
A
R
M
G
Q
Q
T
L
L
L
-
T
H
N
I
D
T
L
G
----------
Q
M
S
------
C
N
P
A
I
G
G
I
G
----
K
G
H
L
V
K
E
V
D
A
L
G
G
L
M
A
K
A
I
D
Q
A
G
----
I
Q
F
R
I
L
N
A
S
K
G
P
A
V
R
A
T
R
A
Q
A
D
R
V
L
Y
R
--------
Q
A
V
R
T
A
L
E
N
Q
-----
P
N
L
M
I
F
Q
Q
A
V
E
D
L
I
V
E
N
D
R
V
V
G
A
V
T
Q
M
G
L
K
F
R
A
K
A
V
V
L
T
V
G
T
F
------------------------
I
P
-
L
S
R
R
L
R
E
-
L
P
L
--
R
V
G
R
L
K
T
G
T
P
P
R
I
D
A
R
T
I
D
F
S
V
L
A
Q
Q
H
G
D
N
P
M
---
P
V
F
S
F
M
G
N
A
---
S
-
Q
H
P
----
Q
Q
V
-
P
C
Y
I
T
H
T
N
---------------------------------------------------------------
D
R
N
Q
H
Q
I
F
L
E
P
E
G
L
T
S
N
E
I
Y
P
N
-
G
I
S
T
-----
S
L
P
F
D
V
Q
M
Q
I
V
R
S
M
Q
-----
G
M
E
N
A
K
I
V
R
P
G
Y
A
I
E
Y
D
F
F
D
-
P
R
D
L
K
P
T
L
E
S
K
F
I
Q
G
L
F
F
A
G
Q
I
N
G
T
T
G
------
Y
E
E
A
A
A
Q
G
L
L
A
G
L
N
A
A
R
L
S
A
D
K
----
E
G
W
A
P
A
R
S
Q
A
Y
L
G
V
L
V
D
D
L
C
T
L
G
T
K
E
P
Y
R
M
F
T
S
R
A
E
Y
R
L
M
L
R
E
D
N
A
D
L
R
L
T
E
I
G
R
E
L
G
L
V
D
D
E
--
R
W
A
R
F
N
E
K
L
E
N
I
E
R
E
R
Q
R
L
K
S
T
W
V
T
P
S
A
E
A
A
A
E
V
N
A
H
L
T
A
P
L
S
R
E
A
S
G
E
D
L
L
R
R
P
E
M
T
Y
E
K
L
T
T
----
L
T
P
F
A
P
------
A
-
L
T
D
E
Q
--
A
A
E
Q
V
E
I
Q
V
K
Y
E
G
Y
I
A
----------------------------------------------------------------------------
111
HHSearch
53.37
23%
-48
- C5 -
3G5S
8
TRMFO_THET8
A:
[1-427]
---
M
-
E
R
V
N
V
V
G
A
G
L
A
G
S
E
A
A
W
T
L
L
R
L
G
V
P
V
R
L
F
-
E
M
R
P
-
K
R
M
TPAHGTDRFA
E
I
V
------
C
S
N
S
L
G
G
E
G
ETN
A
K
G
L
L
Q
A
E
M
R
R
A
G
S
L
V
M
E
A
A
D
L
A
R
--------------
V
P
A
--
G
G
A
L
A
V
D
R
E
E
F
S
--------
G
Y
I
T
E
R
L
T
G
H
-----
P
L
L
------------------
E
V
V
R
E
E
V
R
E
I
P
P
G
I
T
V
L
A
T
G
P
L
---------------------
T
S
-
E
A
-
L
A
E
A
L
K
R
R
F
G
D
--
H
F
L
A
Y
Y
D
A
A
S
P
I
V
L
Y
E
S
I
D
L
T
K
C
F
R
A
G
R
Y
----------------------------
Y
L
-
N
C
P
M
T
E
E
E
Y
R
R
F
H
Q
A
L
L
E
---
A
Q
R
H
T
P
H
---------
F
E
A
C
V
P
V
E
E
L
A
R
R
GYQ
T
L
L
F
G
PMKPVGLVDPRTG
K
E
P
F
A
V
V
Q
L
R
Q
E
D
K
A
G
R
M
W
S
L
V
-
G
F
Q
T
-----
G
L
K
W
P
E
Q
K
R
L
I
Q
M
I
P
-----
G
L
E
N
A
E
I
V
R
Y
G
V
M
H
R
N
T
Y
L
N
A
P
R
L
L
G
E
T
L
E
F
R
E
A
E
G
L
Y
A
A
G
V
L
A
G
V
E
G
------
Y
L
E
S
A
A
T
G
F
L
A
G
L
N
A
A
R
K
A
L
G
L
----
P
P
V
A
P
-
P
E
E
S
M
L
G
G
L
V
R
Y
L
A
T
A
N
P
E
G
F
Q
P
M
-----------------------
Y
A
N
W
G
L
V
P
P
V
EG
R
M
G
K
K
E
K
R
Q
A
M
Y
R
R
G
L
E
A
F
S
A
W
---------------------------------------------------------------------------------------------------------------------------------------------------------------
133
Fugue
44.46
23%
-10
- C6 -
4OPU
3
?
A:
[2-453]
M
K
E
L
K
Y
D
V
L
I
I
G
G
G
F
A
G
S
S
A
A
Y
Q
L
S
R
R
G
L
K
I
L
L
V
D
S
K
P
W
N
R
I
G
----------
D
K
P
------
C
G
D
A
V
S
-----------
K
A
H
F
D
K
L
G
M
P
Y
P
K
G
E
E
L
E
N
KIN
G
I
K
L
Y
S
P
D
M
Q
T
V
W
T
V
N
H
E
G
F
E
L
N
A
P
L
Y
N
--------
Q
R
V
L
K
E
A
Q
D
R
G
V
E
I
W
D
L
T
T
A
M
K
P
I
F
E
D
G
Y
V
K
G
A
V
L
F
N
R
R
T
N
E
E
L
T
V
Y
S
K
V
V
V
E
A
T
G
-------------
Y
S
R
S
F
R
-
S
K
L
P
P
E
L
P
-
I
T
E
D
L
D
D
-
K
D
A
--
D
V
A
Y
R
E
V
L
L
T
-----------
K
E
D
I
E
D
H
D
Y
L
R
---
I
F
I
D
Q
-
E
T
S
-------------------------------------------------
P
G
G
Y
W
W
Y
F
P
------------------------------------------
K
G
K
N
K
V
N
V
G
L
G
I
Q
G
GMGYP
S
I
H
E
Y
Y
K
K
Y
L
D
K
Y
A
P
-----
D
V
D
K
S
K
L
L
V
K
G
-----
G
A
L
V
-
P
T
R
----------
R
P
L
Y
T
M
------------------
A
W
N
G
I
I
V
-
I
G
D
S
G
F
T
V
N
P
VHGG
G
K
G
S
A
M
I
S
G
Y
C
A
A
K
A
I
L
S
A
F
E
T
G
D
F
S
A
S
G
L
W
D
M
N
I
C
Y
V
N
E
--------------
Y
G
A
K
Q
A
S
L
D
--
I
F
R
R
F
L
Q
K
L
S
N
D
D
I
N
Y
G
M
K
K
K
I
I
K
E
E
D
L
L
E
A
S
E
K
G
D
L
H
L
S
V
A
D
K
A
M
R
V
I
S
G
L
G
R
P
S
---------------
L
L
F
------
K
-
L
-
K
A
V
--
A
E
S
M
K
K
I
K
E
L
Y
L
N
Y
P
R
---------------------
S
P
S
S
L
G
S
W
R
R
E
V
D
N
V
L
T
E
F
N
K
S
L
S
-------------------------------
121
HHSearch
43.78
27%
-72
- C5 -
2CUL
1
?
A:
[2-158]
--
A
A
-
Y
Q
V
L
I
V
G
A
G
F
S
G
A
E
T
A
F
W
L
A
Q
K
G
V
R
V
G
L
L
-
T
Q
S
L
-
D
A
V
----------
M
M
P
------
F
L
P
P
K
P
P
F
P
----
P
G
S
L
----------
L
E
R
A
Y
D
---------------
P
K
D
E
---------
R
V
W
A
F
H
--------
A
R
A
K
Y
L
L
E
G
L
-----
R
P
L
H
L
F
Q
A
T
A
T
G
L
L
L
E
G
N
R
V
V
G
V
R
T
W
E
G
P
P
A
R
G
E
K
V
V
L
A
V
G
S
F
L
G
A
R
L
F
L
G
G
V
V
E
E
A
G
R
L
-
S
E
A
S
Y
-
P
D
-
L
L
E
D
L
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
9
PsiBlast_PDB
42.35
25%
-73
- C5 -
2CUL
1
?
A:
[4-166]
-----
Y
Q
V
L
I
V
G
A
G
F
S
G
A
E
T
A
F
W
L
A
Q
K
G
V
R
V
G
L
L
-
T
Q
S
L
D
A
V
M
----------
M
P
F
------
L
P
P
K
P
P
F
P
P
----
G
S
L
L
E
R
A
Y
D
P
--------------------------
K
D
E
R
V
W
A
F
H
A
R
A
-----------------
K
Y
L
L
E
G
L
-----
R
P
L
H
L
F
Q
A
T
A
T
G
L
L
L
E
G
N
R
V
V
G
V
R
T
W
E
G
P
P
A
R
G
E
K
V
V
L
A
V
G
S
F
L
G
A
R
L
F
L
G
G
V
V
E
E
A
G
R
L
-
S
E
A
S
Y
-
P
D
-
L
L
E
D
L
S
R
-
L
G
F
--
R
F
V
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
132
Fugue
40.28
16%
-38
- C1 -
2I0Z
2
?
A:
[25-444]
--
M
H
-
Y
D
V
I
V
I
G
G
G
P
S
G
L
M
A
A
I
G
A
A
E
E
G
A
N
V
L
L
L
-
D
K
G
N
K
L
G
R
----------
K
L
A
I
SGGGR
C
N
V
T
N
R
L
P
L
----
D
E
I
V
K
H
--
I
P
G
N
G
R
F
L
Y
S
A
F
S
I
F
----
N
N
E
D
I
I
T
F
F
E
N
L
G
V
K
L
K
E
E
D
H
G
R
M
F
P
V
SNK
A
Q
S
V
V
D
A
L
L
T
R
L
K
D
L
-----
G
V
K
I
R
T
N
T
P
V
E
T
I
E
Y
E
N
G
Q
T
K
A
V
I
L
Q
T
G
E
V
L
E
T
N
H
V
V
I
A
V
G
G
K
S
V
P
Q
T
G
S
T
G
D
G
Y
A
W
A
E
K
-
A
G
H
T
I
-
T
E
-
L
F
P
T
E
V
P
-
I
L
S
NE
P
F
I
R
D
R
S
L
Q
G
L
A
L
R
D
I
N
L
S
V
L
N
A
I
I
S
H
K
M
D
M
L
F
T
H
F
G
L
S
G
-
P
A
A
---
L
-
R
C
S
----
Q
F
V
-
V
K
A
L
K
K
F
K
T
-
N
T
I
Q
M
S
I
D
ALP
E
E
N
S
E
Q
L
F
Q
R
M
L
K
Q
M
K
E
D
P
K
K
G
I
K
N
V
L
------
K
G
Y
V
-------------
P
E
R
Y
F
L
F
L
L
E
K
N
E
I
D
G
S
E
Q
A
G
Q
-
V
S
H
E
-----
K
I
R
A
L
V
K
D
F
K
E
F
T
V
N
V
N
G
TQ
S
I
E
K
A
F
V
T
G
G
G
--
V
S
V
K
E
I
N
-
P
----
K
E
M
S
S
K
F
T
N
G
L
Y
F
C
G
E
V
L
D
I
H
G
Y
T
GG
Y
N
I
T
S
A
L
V
T
G
R
I
A
G
T
T
A
G
E
N
A
K
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------