@TOME V2.3
(Nov 2016)
Ref.
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : jhp_0199: (2015-12-13 )
MVKESDILVVGGGHAGIEASLIAAKMGVRVHLITMLIDTIGLASCNPAIGGLGKGHLTKEVDVLGGAMGIITDHSGLQYRVLNASKGPAVRGTRAQIDMDTYRIFARNLVLNTPNLSVSQEMTESLILENDEVVGVTTNINNTYRAKKVIITTGTFLKGVVHIGEHQNQNGRFGENASNSLALNLRELGFKVERLKTGTCPRVAGNSIDFEGLEEHFGDANPPYFSYKTKDFNPTQLSCFITYTNPITHQIIRDNFHRAPLFSGQIEGIGPRYCPSIEDKINRFSEKERHQLFLEPQTIHKSEYYINGLSTSLPLDVQEKVIHSIKGLENALITRYGYAIEYDFIQPTELTHALETKKIKGLYLAGQINGTTGYEEAAAQGLMAGINAVLALKNQAPFILKRNEAYIGVLIDDLVTKGTNEPYRMFTSRAEYRLLLREDNTLFRLGEHAYRLGLMEQDFYKELEKDKQAIQENLKRLKECVLTPSKEVLKRLNELGENPINDKMDGVSLLARDSFNLEKMRSFFSFLVPLNERVLEQIKIECKYNIYIEKQHENIAKMDSMLKVSIPKHFVFKGIPGLSLEAVEKLEKFRPKSLFEASEISGITPANLDVLHLYIHLRKNS
Atome Classification :
(20 SA)
.........10........20........30........---------40........50..----......60........70........80........90........100.......110.......120.......130.......140.......150.......160.......170-.-......180.....-..190........200.......210.......220.....-.-.230.-..-------.....240...-....250.......260.......270.......280-----....-------------....290.......300.......310.......320.......330.......340....-...350.......360.......370.......380.......390.......400.......410.......420.......430.......440.......450......--.460-.........470.......480.......490.......500.......510......-------.520......------.-530........540.......550---.......560.......570.......580.......590.......600.......610.......620
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MVKES
D
I
L
V
VGGGHAG
I
E
A
S
L
I
A
A
KMG
V
R
V
H
L
I
T
M
L
I
D
T
---------IGLASCNPAIGGLG----KGHL
T
K
E
V
D
VLGG
A
M
G
I
I
TDHSG
L
Q
Y
R
V
LNASKGPAVRG
T
R
A
Q
I
D
M
D
T
Y
R
I
F
A
R
N
LVLNTPNL
S
V
S
Q
E
M
T
E
S
L
ILEND
E
V
V
G
V
TTNINN
T
Y
R
A
K
K
V
I
I
TT
G
T
F
L
K
G
V
V
H
IGEHQNQNGR-F-GENASN
S
L
A
L
N
L
R
E
-LG
F
K
-
V
E
R
LKTGTCPRVAGNSI
D
F
E
G
L
E
E
HFGDANPP
Y
F
S
Y
-K-TKD-F-
N
P
-------
T
Q
L
S
C
F
I
T
YTN-
P
I
T
H
Q
I
I
R
DNFHRAPLFSGQIEGIGPRYCP
S
I
E
D
K
I
------
N
R
F
S
-------------
E
K
E
R
H
Q
L
F
LEPQTIHKS
E
Y
Y
I
NGLSTSLP
L
D
V
Q
E
K
V
I
H
S
I
K
G
L
E
N
A
L
I
T
RYG
Y
A
I
E
Y
DFIQ-
P
T
E
L
T
H
A
L
ETK
K
I
K
G
L
Y
L
A
G
QINGTTG
Y
E
E
A
A
A
Q
G
L
M
A
G
I
N
A
V
L
A
LKNQA
P
F
I
L
KRNE
A
Y
I
G
V
L
I
D
D
L
V
TKGTN
E
P
Y
R
M
F
TSRA
E
Y
R
L
L
L
REDN
T
L
F
R
L
G
E
H
A
Y
RLGL
M
E
Q
D
--
F
Y
---
K
E
L
E
K
D
K
Q
A
I
Q
E
N
L
K
R
L
K
E
C
VLT
P
S
K
E
V
L
K
R
L
N
E
LGENPINDKMD
G
V
S
L
L
A
RDSF
N
L
E
-------
K
M
R
S
F
F
S
F
L
V
------
P
-
L
-
N
E
R
V
L
E
Q
I
K
I
E
C
K
Y
N
I
Y
I
E
K
Q
H
---
E
N
I
A
K
M
D
S
M
L
K
VSIP
K
H
F
V
FKGIPGL
S
L
E
A
V
E
K
L
E
KFR
P
K
SLF
E
A
S
EISGITPAN
L
D
V
L
H
L
Y
I
H
L
RKNS
28
PsiBlast_CBE
90.88
42%
-85
- C4 -
3CP8
1
MNMG_CHLTE
B:
[23-639]
-----
D
V
I
V
V
G
A
G
H
A
G
C
E
A
A
L
A
V
A
R
G
G
L
H
C
L
L
I
T
S
D
L
S
A
---------
V
A
R
M
S
C
N
P
A
I
G
G
V
A
----
K
G
Q
I
T
R
E
I
D
A
L
G
G
E
M
G
K
A
I
D
A
T
G
I
Q
F
R
M
L
N
R
S
K
G
P
A
M
H
S
P
R
A
Q
A
D
K
T
Q
Y
S
L
Y
M
R
R
I
V
E
H
E
P
N
I
D
L
L
Q
D
T
V
I
G
V
S
A
N
S
G
K
F
S
S
V
T
V
R
S
G
R
A
I
Q
A
K
A
A
I
L
A
C
G
T
F
L
N
G
L
I
H
I
G
M
D
H
F
P
G
G
R
S
T
-
A
E
P
P
V
E
G
L
T
E
S
L
A
S
-
L
G
F
S
-
F
G
R
L
K
T
G
T
P
P
R
I
D
S
R
S
V
D
Y
T
I
V
T
E
Q
P
G
D
V
D
P
V
P
F
S
F
-
S
-
S
T
S
-
V
A
N
R
-------
N
L
V
S
C
Y
L
T
K
T
T
-
E
K
T
H
D
I
L
R
T
G
F
D
R
S
P
L
F
T
G
---------
C
P
S
I
E
D
K
I
------
S
R
F
P
-------------
D
K
S
S
H
H
I
F
L
E
P
E
G
T
D
T
V
E
M
Y
V
N
G
F
S
T
S
L
P
E
D
I
Q
I
A
G
L
R
S
I
P
G
L
E
E
A
K
M
I
R
P
G
Y
A
I
E
Y
D
F
F
H
-
P
W
Q
I
R
S
T
M
E
T
R
P
V
E
N
L
F
F
A
G
Q
I
N
G
T
S
G
Y
E
E
A
A
A
Q
G
L
M
A
G
I
N
A
V
R
K
I
L
G
K
E
L
I
V
L
G
R
D
Q
A
Y
I
G
V
L
I
D
D
L
I
T
K
E
T
K
E
P
Y
R
M
F
T
S
S
A
E
H
R
L
I
L
R
H
D
N
A
D
L
R
L
R
K
I
G
Y
D
C
N
L
V
S
S
D
--
D
L
---
H
R
T
E
S
I
I
K
R
V
Q
H
C
L
E
V
M
K
T
A
K
V
T
P
A
-
E
I
N
T
L
L
M
N
K
G
L
Q
E
L
K
T
P
A
R
A
L
S
L
I
K
R
P
G
I
S
L
Q
DILEHSL
S
V
R
S
A
A
E
E
L
C
------
N
---
D
P
R
V
A
E
Q
V
Q
I
E
I
K
Y
E
G
Y
I
K
R
E
Q
LVA
D
R
I
A
R
L
D
S
L
---
H
I
P
D
N
F
N
Y
D
S
L
N
S
L
S
S
E
G
R
E
K
L
L
K
H
R
P
A
T
I
G
Q
A
S
R
I
L
G
V
S
P
S
D
V
S
I
L
M
I
R
L
------
27
PsiBlast_CBE
90.75
42%
-86
- C4 -
3CP8
1
MNMG_CHLTE
C:
[23-639]
-----
D
V
I
V
V
G
A
G
H
A
G
C
E
A
A
L
A
V
A
R
G
G
L
H
C
L
L
I
T
S
D
L
S
A
---------
V
A
R
M
S
C
N
P
A
I
G
G
V
A
----
K
G
Q
I
T
R
E
I
D
A
L
G
G
E
M
G
K
A
I
D
A
T
G
I
Q
F
R
M
L
N
R
S
K
G
P
A
M
H
S
P
R
A
Q
A
D
K
T
Q
Y
S
L
Y
M
R
R
I
V
E
H
E
P
N
I
D
L
L
Q
D
T
V
I
G
V
S
A
N
S
G
K
F
S
S
V
T
V
R
S
G
R
A
I
Q
A
K
A
A
I
L
A
C
G
T
F
L
N
G
L
I
H
I
G
M
D
H
F
P
G
G
R
S
T
-
A
E
P
P
V
E
G
L
T
E
S
L
A
S
-
L
G
F
S
-
F
G
R
L
K
T
G
T
P
P
R
I
D
S
R
S
V
D
Y
T
I
V
T
E
Q
P
G
D
V
D
P
V
P
F
S
F
-
S
-
S
T
S
-
V
A
N
R
-------
N
L
V
S
C
Y
L
T
K
T
T
-
E
K
T
H
D
I
L
R
T
G
F
D
R
S
P
L
F
T
G
---------
C
P
S
I
E
D
K
I
------
S
R
F
P
-------------
D
K
S
S
H
H
I
F
L
E
P
E
G
T
D
T
V
E
M
Y
V
N
G
F
S
T
S
L
P
E
D
I
Q
I
A
G
L
R
S
I
P
G
L
E
E
A
K
M
I
R
P
G
Y
A
I
E
Y
D
F
F
H
-
P
W
Q
I
R
S
T
M
E
T
R
P
V
E
N
L
F
F
A
G
Q
I
N
G
T
S
G
Y
E
E
A
A
A
Q
G
L
M
A
G
I
N
A
V
R
K
I
L
G
K
E
L
I
V
L
G
R
D
Q
A
Y
I
G
V
L
I
D
D
L
I
T
K
E
T
K
E
P
Y
R
M
F
T
S
S
A
E
H
R
L
I
L
R
H
D
N
A
D
L
R
L
R
K
I
G
Y
D
C
N
L
V
S
S
D
--
D
L
---
H
R
T
E
S
I
I
K
R
V
Q
H
C
L
E
V
M
K
T
A
K
V
T
P
A
-
E
I
N
T
L
L
M
N
K
G
L
Q
E
L
K
T
P
A
R
A
L
S
L
I
K
R
P
G
I
S
L
Q
DILEHSL
S
V
R
S
A
A
E
E
L
C
------
N
---
D
P
R
V
A
E
Q
V
Q
I
E
I
K
Y
E
G
Y
I
K
R
E
Q
LVA
D
R
I
A
R
L
D
S
L
---
H
I
P
D
N
F
N
Y
D
S
L
N
S
L
S
S
E
G
R
E
K
L
L
K
H
R
P
A
T
I
G
Q
A
S
R
I
L
G
V
S
P
S
D
V
S
I
L
M
I
R
L
------
5
PsiBlast_PDB
90.66
42%
-84
- C4 -
3CP8
1
MNMG_CHLTE
A:
[23-639]
-----
D
V
I
V
V
G
A
G
H
A
G
C
E
A
A
L
A
V
A
R
G
G
L
H
C
L
L
I
T
S
D
L
S
A
---------
V
A
R
M
S
C
N
P
A
I
G
G
V
A
----
K
G
Q
I
T
R
E
I
D
A
L
G
G
E
M
G
K
A
I
D
A
T
G
I
Q
F
R
M
L
N
R
S
K
G
P
A
M
H
S
P
R
A
Q
A
D
K
T
Q
Y
S
L
Y
M
R
R
I
V
E
H
E
P
N
I
D
L
L
Q
D
T
V
I
G
V
S
A
N
S
G
K
F
S
S
V
T
V
R
S
G
R
A
I
Q
A
K
A
A
I
L
A
C
G
T
F
L
N
G
L
I
H
I
G
M
D
H
F
P
G
G
R
S
T
-
A
E
P
P
V
E
G
L
T
E
S
L
A
S
-
L
G
F
S
-
F
G
R
L
K
T
G
T
P
P
R
I
D
S
R
S
V
D
Y
T
I
V
T
E
Q
P
G
D
V
D
P
V
P
F
S
F
-
S
-
S
T
S
-
V
A
N
R
-------
N
L
V
S
C
Y
L
T
K
T
T
-
E
K
T
H
D
I
L
R
T
G
F
D
R
S
P
L
F
T
G
---------
C
P
S
I
E
D
K
I
------
S
R
F
P
-------------
D
K
S
S
H
H
I
F
L
E
P
E
G
T
D
T
V
E
M
Y
V
N
G
F
S
T
S
L
P
E
D
I
Q
I
A
G
L
R
S
I
P
G
L
E
E
A
K
M
I
R
P
G
Y
A
I
E
Y
D
F
F
H
-
P
W
Q
I
R
S
T
M
E
T
R
P
V
E
N
L
F
F
A
G
Q
I
N
G
T
S
G
Y
E
E
A
A
A
Q
G
L
M
A
G
I
N
A
V
R
K
I
L
G
K
E
L
I
V
L
G
R
D
Q
A
Y
I
G
V
L
I
D
D
L
I
T
K
E
T
K
E
P
Y
R
M
F
T
S
S
A
E
H
R
L
I
L
R
H
D
N
A
D
L
R
L
R
K
I
G
Y
D
C
N
L
V
S
S
D
--
D
L
---
H
R
T
E
S
I
I
K
R
V
Q
H
C
L
E
V
M
K
T
A
K
V
T
P
A
-
E
I
N
T
L
L
M
N
K
G
L
Q
E
L
K
T
P
A
R
A
L
S
L
I
K
R
P
G
I
S
L
Q
D
I
L
E
H
S
L
S
V
R
S
A
A
E
E
L
C
------
N
---
D
P
R
V
A
E
Q
V
Q
I
E
I
K
Y
E
G
Y
I
K
R
E
Q
L
V
A
D
R
I
A
R
L
D
S
L
---
H
I
P
D
N
F
N
Y
D
S
L
N
S
L
S
S
E
G
R
E
K
L
L
K
H
R
P
A
T
I
G
Q
A
S
R
I
L
G
V
S
P
S
D
V
S
I
L
M
I
R
L
------
61
HHSearch
90.61
42%
-81
- C4 -
3CP8
1
MNMG_CHLTE
A:
[20-639]
--
H
M
Y
D
V
I
V
V
G
A
G
H
A
G
C
E
A
A
L
A
V
A
R
G
G
L
H
C
L
L
I
T
S
D
L
S
A
---------
V
A
R
M
S
C
N
P
A
I
G
G
V
A
----
K
G
Q
I
T
R
E
I
D
A
L
G
G
E
M
G
K
A
I
D
A
T
G
I
Q
F
R
M
L
N
R
S
K
G
P
A
M
H
S
P
R
A
Q
A
D
K
T
Q
Y
S
L
Y
M
R
R
I
V
E
H
E
P
N
I
D
L
L
Q
D
T
V
I
G
V
S
A
N
S
G
K
F
S
S
V
T
V
R
S
G
R
A
I
Q
A
K
A
A
I
L
A
C
G
T
F
L
N
G
L
I
H
I
G
M
D
H
F
P
G
G
R
-
S
T
A
E
P
P
V
E
G
L
T
E
S
L
A
S
-
L
G
F
S
-
F
G
R
L
K
T
G
T
P
P
R
I
D
S
R
S
V
D
Y
T
I
V
T
E
Q
P
G
D
V
D
P
V
P
F
S
F
-
S
-
S
T
S
-
V
A
N
R
-------
N
L
V
S
C
Y
L
T
K
T
T
-
E
K
T
H
D
I
L
R
T
G
F
D
R
S
P
L
F
T
G
---------
C
P
S
I
E
D
K
I
------
S
R
F
P
-------------
D
K
S
S
H
H
I
F
L
E
P
E
G
T
D
T
V
E
M
Y
V
N
G
F
S
T
S
L
P
E
D
I
Q
I
A
G
L
R
S
I
P
G
L
E
E
A
K
M
I
R
P
G
Y
A
I
E
Y
D
F
F
H
-
P
W
Q
I
R
S
T
M
E
T
R
P
V
E
N
L
F
F
A
G
Q
I
N
G
T
S
G
Y
E
E
A
A
A
Q
G
L
M
A
G
I
N
A
V
R
K
I
L
G
K
E
L
I
V
L
G
R
D
Q
A
Y
I
G
V
L
I
D
D
L
I
T
K
E
T
K
E
P
Y
R
M
F
T
S
S
A
E
H
R
L
I
L
R
H
D
N
A
D
L
R
L
R
K
I
G
Y
D
C
N
L
V
S
S
D
--
D
L
---
H
R
T
E
S
I
I
K
R
V
Q
H
C
L
E
V
M
K
T
A
K
V
T
P
A
E
I
N
T
L
-
L
M
N
K
G
L
Q
E
L
K
T
P
A
R
A
L
S
L
I
K
R
P
G
I
S
L
Q
-------
D
I
L
E
H
S
L
S
V
R
S
A
AE
E
L
C
-
N
-
D
P
R
V
A
E
Q
V
Q
I
E
I
K
Y
E
G
Y
I
K
R
E
Q
---
L
V
A
D
R
I
A
R
L
D
S
L
H
I
P
D
N
F
N
Y
D
S
L
N
S
L
S
S
E
G
R
E
K
L
L
K
H
R
P
A
T
I
G
Q
A
S
R
I
L
G
V
S
P
S
D
V
S
I
L
M
I
R
L
------
24
PsiBlast_CBE
88.83
45%
-81
- C4 -
2ZXH
4
MNMG_AQUAE
B:
[26-633]
--
D
E
F
D
V
V
V
I
G
G
G
H
A
G
I
E
A
A
L
A
A
A
R
M
G
A
K
T
A
M
F
V
L
N
A
D
T
---------
I
G
Q
M
S
C
N
P
A
I
G
G
I
A
----
K
G
I
V
V
R
E
I
D
A
L
G
G
E
M
G
K
A
I
D
Q
T
G
I
Q
F
K
M
L
N
T
R
K
G
K
A
V
Q
S
P
R
A
Q
A
D
K
K
R
Y
R
E
Y
M
K
K
V
C
E
N
Q
E
N
L
Y
I
K
Q
E
E
V
V
D
I
I
V
K
N
N
Q
V
V
G
V
R
T
N
L
G
V
E
Y
K
T
K
A
V
V
V
T
T
G
T
F
L
N
G
V
I
Y
I
G
D
K
M
I
P
G
G
R
-
L
-
G
E
P
R
S
E
G
L
S
D
F
Y
R
R
-
F
D
F
P
-
L
I
R
F
K
T
G
T
P
A
R
L
D
K
R
T
I
D
F
S
A
L
E
V
A
P
G
D
D
P
P
P
K
F
S
F
-
W
-
T
E
P
-
V
-
G
S
YWFPKGK
E
Q
V
N
C
W
I
T
Y
T
T
-
P
K
T
H
E
I
I
R
K
N
L
H
R
T
A
L
Y
G
G
L
I
K
G
I
G
P
R
Y
C
P
S
I
E
D
K
I
------
V
K
F
P
-------------
D
K
E
R
H
Q
I
F
L
E
P
E
G
L
D
T
I
E
I
Y
P
N
G
L
S
T
S
L
P
E
E
V
Q
W
E
M
Y
R
S
I
P
G
L
E
N
V
V
L
I
R
P
A
Y
A
I
E
Y
D
V
V
P
-
P
T
E
L
Y
P
T
L
E
T
K
K
I
R
G
L
F
H
A
G
N
F
N
G
T
T
G
Y
E
E
A
A
G
Q
G
I
V
A
G
I
N
A
A
L
R
A
F
G
K
E
P
I
Y
L
R
R
D
E
S
Y
I
G
V
M
I
D
D
L
T
T
K
G
V
T
E
P
Y
R
L
F
T
S
R
S
E
Y
R
L
Y
I
R
Q
D
N
A
I
L
R
L
A
K
L
G
R
E
L
G
L
L
S
E
E
--
Q
Y
KLV
K
E
L
E
R
E
I
E
K
W
K
E
F
Y
K
S
E
R
V
-----------------------
R
S
Y
S
V
A
T
L
M
T
M
N
Y
T
L
D
-------
D
V
K
E
K
F
G
Y
E
V
------
P
-
Q
-
H
P
Y
V
K
E
E
V
E
I
Q
L
K
Y
E
P
Y
I
E
R
E
R
---
K
L
N
E
K
L
K
K
L
E
D
T
K
I
P
P
D
I
D
Y
D
K
I
P
G
L
T
K
E
A
R
E
K
L
K
K
F
K
P
I
T
V
G
Q
A
S
R
I
D
G
I
T
P
A
A
I
T
A
L
L
V
Y
L
G
-----
3
PsiBlast_PDB
88.11
45%
-79
- C4 -
2ZXH
3
MNMG_AQUAE
A:
[26-633]
--
D
E
F
D
V
V
V
I
G
G
G
H
A
G
I
E
A
A
L
A
A
A
R
M
G
A
K
T
A
M
F
V
L
N
A
D
T
---------
I
G
Q
M
S
C
N
P
A
I
G
G
I
A
----
K
G
I
V
V
R
E
I
D
A
L
G
G
E
M
G
K
A
I
D
Q
T
G
I
Q
F
K
M
L
N
T
R
K
G
K
A
V
Q
S
P
R
A
Q
A
D
K
K
R
Y
R
E
Y
M
K
K
V
C
E
N
Q
E
N
L
Y
I
K
Q
E
E
V
V
D
I
I
V
K
N
N
Q
V
V
G
V
R
T
N
L
G
V
E
Y
K
T
K
A
V
V
V
T
T
G
T
F
L
N
G
V
I
Y
I
G
D
K
M
I
P
G
G
R
-
L
-
G
E
P
R
S
E
G
L
S
D
F
Y
R
R
-
F
D
F
P
-
L
I
R
F
K
T
G
T
P
A
R
L
D
K
R
T
I
D
F
S
A
L
E
V
A
P
G
D
D
P
P
P
K
F
S
F
-
W
-
T
E
P
-
V
-
G
S
YWFPKG
K
E
Q
V
N
C
W
I
T
Y
T
T
-
P
K
T
H
E
I
I
R
K
N
L
H
R
T
A
L
Y
G
G
L
I
K
G
I
G
P
R
Y
C
P
S
I
E
D
K
I
------
V
K
F
P
-------------
D
K
E
R
H
Q
I
F
L
E
P
E
G
L
D
T
I
E
I
Y
P
N
G
L
S
T
S
L
P
E
E
V
Q
W
E
M
Y
R
S
I
P
G
L
E
N
V
V
L
I
R
P
A
Y
A
I
E
Y
D
V
V
P
-
P
T
E
L
Y
P
T
L
E
T
K
K
I
R
G
L
F
H
A
G
N
F
N
G
T
T
G
Y
E
E
A
A
G
Q
G
I
V
A
G
I
N
A
A
L
R
A
F
G
K
E
P
I
Y
L
R
R
D
E
S
Y
I
G
V
M
I
D
D
L
T
T
K
G
V
T
E
P
Y
R
L
F
T
S
R
S
E
Y
R
L
Y
I
R
Q
D
N
A
I
L
R
L
A
K
L
G
R
E
L
G
L
L
S
E
E
--
Q
Y
K
L
V
K
E
L
E
R
E
I
E
K
W
K
E
F
Y
K
S
E
R
V
-----------------------
R
S
Y
S
V
A
T
L
M
T
M
N
Y
T
L
D
-------
D
V
K
E
K
F
G
Y
E
V
------
P
-
Q
-
H
P
Y
V
K
E
E
V
E
I
Q
L
K
Y
E
P
Y
I
E
R
E
R
---
K
L
N
E
K
L
K
K
L
E
D
T
K
I
P
P
D
I
D
Y
D
K
I
P
G
L
T
K
E
A
R
E
K
L
K
K
F
K
P
I
T
V
G
Q
A
S
R
I
D
G
I
T
P
A
A
I
T
A
L
L
V
Y
L
G
K
L
---
23
PsiBlast_CBE
87.89
45%
-78
- C4 -
2ZXI
1
MNMG_AQUAE
B:
[24-633]
V
V
D
E
F
D
V
V
V
I
G
G
G
H
A
G
I
E
A
A
L
A
A
A
R
M
G
A
K
T
A
M
F
V
L
N
A
D
T
---------
I
G
Q
M
S
C
N
P
A
I
G
G
I
A
----
K
G
I
V
V
R
E
I
D
A
L
G
G
E
M
G
K
A
I
D
Q
T
G
I
Q
F
K
M
L
N
T
R
K
G
K
A
V
Q
S
P
R
A
Q
A
D
K
K
R
Y
R
E
Y
M
K
K
V
C
E
N
Q
E
N
L
Y
I
K
Q
E
E
V
V
D
I
I
V
K
N
N
Q
V
V
G
V
R
T
N
L
G
V
E
Y
K
T
K
A
V
V
V
T
T
G
T
F
L
N
G
V
I
Y
I
G
D
K
M
I
P
G
G
R
-
L
-
G
E
P
R
S
E
G
L
S
D
F
Y
R
R
-
F
D
F
P
-
L
I
R
F
K
T
G
T
P
A
R
L
D
K
R
T
I
D
F
S
A
L
E
V
A
P
G
D
D
P
P
P
K
F
S
F
-
W
-
T
E
P
-
V
-
G
S
YWFPKGK
E
Q
V
N
C
W
I
T
Y
T
T
-
P
K
T
H
E
I
I
R
K
N
L
H
R
T
A
-----------
R
Y
C
P
S
I
E
D
K
I
------
V
K
F
P
-------------
D
K
E
R
H
Q
I
F
L
E
P
E
G
L
D
T
I
E
I
Y
P
N
G
L
S
T
S
L
P
E
E
V
Q
W
E
M
Y
R
S
I
P
G
L
E
N
V
V
L
I
R
P
A
Y
A
I
E
Y
D
V
V
P
-
P
T
E
L
Y
P
T
L
E
T
K
K
I
R
G
L
F
H
A
G
N
F
N
G
T
T
G
Y
E
E
A
A
G
Q
G
I
V
A
G
I
N
A
A
L
R
A
F
G
K
E
P
I
Y
L
R
R
D
E
S
Y
I
G
V
M
I
D
D
L
T
T
K
G
V
T
E
P
Y
R
L
F
T
S
R
S
E
Y
R
L
Y
I
R
Q
D
N
A
I
L
R
L
A
K
L
G
R
E
L
G
L
L
S
E
E
--
Q
Y
K
L
V
K
E
L
E
R
E
I
E
K
W
K
E
F
Y
K
S
E
R
V
S
V
A
V
G
G
---------------
D
T
R
S
Y
S
V
A
T
L
M
T
M
N
Y
T
L
D
-------
D
V
K
E
K
F
G
Y
E
V
------
P
-
Q
-
H
P
Y
V
K
E
E
V
E
I
Q
L
K
Y
E
P
Y
I
E
R
E
R
---
K
L
N
E
K
L
K
K
L
E
D
T
K
I
P
P
D
I
D
Y
D
K
I
P
G
L
T
K
E
A
R
E
K
L
K
K
F
K
P
I
T
V
G
Q
A
S
R
I
D
G
I
T
P
A
A
I
T
A
L
L
V
Y
L
G
K
----
22
PsiBlast_CBE
87.73
45%
-80
- C4 -
2ZXI
1
MNMG_AQUAE
C:
[24-633]
V
V
D
E
F
D
V
V
V
I
G
G
G
H
A
G
I
E
A
A
L
A
A
A
R
M
G
A
K
T
A
M
F
V
L
N
A
D
T
---------
I
G
Q
M
S
C
N
P
A
I
G
G
I
A
----
K
G
I
V
V
R
E
I
D
A
L
G
G
E
M
G
K
A
I
D
Q
T
G
I
Q
F
K
M
L
N
T
R
K
G
K
A
V
Q
S
P
R
A
Q
A
D
K
K
R
Y
R
E
Y
M
K
K
V
C
E
N
Q
E
N
L
Y
I
K
Q
E
E
V
V
D
I
I
V
K
N
N
Q
V
V
G
V
R
T
N
L
G
V
E
Y
K
T
K
A
V
V
V
T
T
G
T
F
L
N
G
V
I
Y
I
G
D
K
M
I
P
G
G
R
-
L
-
G
E
P
R
S
E
G
L
S
D
F
Y
R
R
-
F
D
F
P
-
L
I
R
F
K
T
G
T
P
A
R
L
D
K
R
T
I
D
F
S
A
L
E
V
A
P
G
D
D
P
P
P
K
F
S
F
-
W
-
T
E
P
-
V
-
G
S
YWFPKGK
E
Q
V
N
C
W
I
T
Y
T
T
-
P
K
T
H
E
I
I
R
K
N
L
H
R
T
A
-----------
R
Y
C
P
S
I
E
D
K
I
------
V
K
F
P
-------------
D
K
E
R
H
Q
I
F
L
E
P
E
G
L
D
T
I
E
I
Y
P
N
G
L
S
T
S
L
P
E
E
V
Q
W
E
M
Y
R
S
I
P
G
L
E
N
V
V
L
I
R
P
A
Y
A
I
E
Y
D
V
V
P
-
P
T
E
L
Y
P
T
L
E
T
K
K
I
R
G
L
F
H
A
G
N
F
N
G
T
T
G
Y
E
E
A
A
G
Q
G
I
V
A
G
I
N
A
A
L
R
A
F
G
K
E
P
I
Y
L
R
R
D
E
S
Y
I
G
V
M
I
D
D
L
T
T
K
G
V
T
E
P
Y
R
L
F
T
S
R
S
E
Y
R
L
Y
I
R
Q
D
N
A
I
L
R
L
A
K
L
G
R
E
L
G
L
L
S
E
E
--
Q
Y
K
L
V
K
E
L
E
R
E
I
E
K
W
K
E
F
Y
K
S
E
R
V
S
V
A
V
G
-----------------
T
R
S
Y
S
V
A
T
L
M
T
M
N
Y
T
L
D
-------
D
V
K
E
K
F
G
Y
E
V
------
P
-
Q
-
H
P
Y
V
K
E
E
V
E
I
Q
L
K
Y
E
P
Y
I
E
R
E
R
---
K
L
N
E
K
L
K
K
L
E
D
T
K
I
P
P
D
I
D
Y
D
K
I
P
G
L
T
K
E
A
R
E
K
L
K
K
F
K
P
I
T
V
G
Q
A
S
R
I
D
G
I
T
P
A
A
I
T
A
L
L
V
Y
L
G
K
----
21
PsiBlast_CBE
87.59
45%
-81
- C4 -
2ZXI
1
MNMG_AQUAE
D:
[24-633]
V
V
D
E
F
D
V
V
V
I
G
G
G
H
A
G
I
E
A
A
L
A
A
A
R
M
G
A
K
T
A
M
F
V
L
N
A
D
T
---------
I
G
Q
M
S
C
N
P
A
I
G
G
I
A
----
K
G
I
V
V
R
E
I
D
A
L
G
G
E
M
G
K
A
I
D
Q
T
G
I
Q
F
K
M
L
N
T
R
K
G
K
A
V
Q
S
P
R
A
Q
A
D
K
K
R
Y
R
E
Y
M
K
K
V
C
E
N
Q
E
N
L
Y
I
K
Q
E
E
V
V
D
I
I
V
K
N
N
Q
V
V
G
V
R
T
N
L
G
V
E
Y
K
T
K
A
V
V
V
T
T
G
T
F
L
N
G
V
I
Y
I
G
D
K
M
I
P
G
G
R
-
L
-
G
E
P
R
S
E
G
L
S
D
F
Y
R
R
-
F
D
F
P
-
L
I
R
F
K
T
G
T
P
A
R
L
D
K
R
T
I
D
F
S
A
L
E
V
A
P
G
D
D
P
P
P
K
F
S
F
-
W
-
T
E
P
-
V
-
G
S
YWFPKGK
E
Q
V
N
C
W
I
T
Y
T
T
-
P
K
T
H
E
I
I
R
K
N
L
H
R
--------------
Y
C
P
S
I
E
D
K
I
------
V
K
F
P
-------------
D
K
E
R
H
Q
I
F
L
E
P
E
G
L
D
T
I
E
I
Y
P
N
G
L
S
T
S
L
P
E
E
V
Q
W
E
M
Y
R
S
I
P
G
L
E
N
V
V
L
I
R
P
A
Y
A
I
E
Y
D
V
V
P
-
P
T
E
L
Y
P
T
L
E
T
K
K
I
R
G
L
F
H
A
G
N
F
N
G
T
T
G
Y
E
E
A
A
G
Q
G
I
V
A
G
I
N
A
A
L
R
A
F
G
K
E
P
I
Y
L
R
R
D
E
S
Y
I
G
V
M
I
D
D
L
T
T
K
G
V
T
E
P
Y
R
L
F
T
S
R
S
E
Y
R
L
Y
I
R
Q
D
N
A
I
L
R
L
A
K
L
G
R
E
L
G
L
L
S
E
E
--
Q
Y
KLV
K
E
L
E
R
E
I
E
K
W
K
E
F
Y
K
S
E
R
V
S
V
A
V
G
G
---------------
D
T
R
S
Y
S
V
A
T
L
M
T
M
N
Y
T
L
D
-------
D
V
K
E
K
F
G
Y
E
V
------
P
-
Q
-
H
P
Y
V
K
E
E
V
E
I
Q
L
K
Y
E
P
Y
I
E
R
E
R
---
K
L
N
E
K
L
K
K
L
E
D
T
K
I
P
P
D
I
D
Y
D
K
I
P
G
L
T
K
E
A
R
E
K
L
K
K
F
K
P
I
T
V
G
Q
A
S
R
I
D
G
I
T
P
A
A
I
T
A
L
L
V
Y
L
G
K
----
26
PsiBlast_CBE
85.75
42%
-83
- C4 -
3CP8
1
MNMG_CHLTE
D:
[23-580]
-----
D
V
I
V
V
G
A
G
H
A
G
C
E
A
A
L
A
V
A
R
G
G
L
H
C
L
L
I
T
S
D
L
S
A
---------
V
A
R
M
S
C
N
P
A
I
G
G
V
A
----
K
G
Q
I
T
R
E
I
D
A
L
G
G
E
M
G
K
A
I
D
A
T
G
I
Q
F
R
M
L
N
R
S
K
G
P
A
M
H
S
P
R
A
Q
A
D
K
T
Q
Y
S
L
Y
M
R
R
I
V
E
H
E
P
N
I
D
L
L
Q
D
T
V
I
G
V
S
A
N
S
G
K
F
S
S
V
T
V
R
S
G
R
A
I
Q
A
K
A
A
I
L
A
C
G
T
F
L
N
G
L
I
H
I
G
M
D
H
F
P
G
G
R
S
T
-
A
E
P
P
V
E
G
L
T
E
S
L
A
S
-
L
G
F
S
-
F
G
R
L
K
T
G
T
P
P
R
I
D
S
R
S
V
D
Y
T
I
V
T
E
Q
P
G
D
V
D
P
V
P
F
S
F
-
S
-
S
T
S
-
V
A
N
R
-------
N
L
V
S
C
Y
L
T
K
T
T
-
E
K
T
H
D
I
L
R
T
G
F
D
R
S
P
L
F
T
G
---------
C
P
S
I
E
D
K
I
------
S
R
F
P
-------------
D
K
S
S
H
H
I
F
L
E
P
E
G
T
D
T
V
E
M
Y
V
N
G
F
S
T
S
L
P
E
D
I
Q
I
A
G
L
R
S
I
P
G
L
E
E
A
K
M
I
R
P
G
Y
A
I
E
Y
D
F
F
H
-
P
W
Q
I
R
S
T
M
E
T
R
P
V
E
N
L
F
F
A
G
Q
I
N
G
T
S
G
Y
E
E
A
A
A
Q
G
L
M
A
G
I
N
A
V
R
K
I
L
G
K
E
L
I
V
L
G
R
D
Q
A
Y
I
G
V
L
I
D
D
L
I
T
K
E
T
K
E
P
Y
R
M
F
T
S
S
A
E
H
R
L
I
L
R
H
D
N
A
D
L
R
L
R
K
I
G
Y
D
C
N
L
V
S
S
D
--
D
L
---
H
R
T
E
S
I
I
K
R
V
Q
H
C
L
E
V
M
K
T
A
K
V
T
P
A
-
E
I
N
T
L
L
M
N
K
G
L
Q
E
L
K
T
P
A
R
A
L
S
L
I
K
R
P
G
I
S
L
Q
DILEHSL
S
V
R
S
A
A
E
E
L
C
------
N
---
D
P
R
V
A
E
Q
V
Q
I
E
I
K
Y
E
G
Y
I
K
R
E
Q
LVA
D
--------------------------------------------------------------------
2
PsiBlast_PDB
85.08
48%
-87
- C4 -
3CES
-
MNMG_ECOLI
A:
[8-550]
-----
D
V
I
I
I
G
G
G
H
A
G
T
E
A
A
M
A
A
A
R
M
G
Q
Q
T
L
L
L
T
H
N
I
D
T
---------
L
G
Q
M
S
C
N
P
A
I
G
G
I
G
----
K
G
H
L
V
K
E
V
D
A
L
G
G
L
M
A
K
A
I
D
Q
A
G
I
Q
F
R
I
L
N
A
S
K
G
P
A
V
R
A
T
R
A
Q
A
D
R
V
L
Y
R
Q
A
V
R
T
A
L
E
N
Q
P
N
L
M
I
F
Q
Q
A
V
E
D
L
I
V
E
N
D
R
V
V
G
A
V
T
Q
M
G
L
K
F
R
A
K
A
V
V
L
T
V
G
T
F
L
D
G
K
I
H
I
G
---------------
S
I
P
L
S
R
R
L
R
E
-
L
P
L
R
-
V
G
R
L
K
T
G
T
P
P
R
I
D
A
R
T
I
D
F
S
V
L
A
Q
Q
H
G
D
N
P
M
P
V
F
S
F
-
M
G
N
A
S
-
Q
-
H
P
-------
Q
Q
V
P
C
Y
I
T
H
T
N
-
E
K
T
H
D
V
I
R
S
N
L
D
R
S
---------------
P
S
I
E
D
K
V
------
M
R
F
A
-------------
D
R
N
Q
H
Q
I
F
L
E
P
E
G
L
T
S
N
E
I
Y
P
N
G
I
S
T
S
L
P
F
D
V
Q
M
Q
I
V
R
S
M
Q
G
M
E
N
A
K
I
V
R
P
G
Y
A
I
E
Y
D
F
F
D
-
P
R
D
L
K
P
T
L
E
S
K
F
I
Q
G
L
F
F
A
G
Q
I
N
G
T
T
G
Y
E
E
A
A
A
Q
G
L
L
A
G
L
N
A
A
R
L
S
A
D
K
E
G
W
A
P
A
R
S
Q
A
Y
L
G
V
L
V
D
D
L
C
T
L
G
T
K
E
P
Y
R
M
F
T
S
R
A
E
Y
R
L
M
L
R
E
D
N
A
D
L
R
L
T
E
I
G
R
E
L
G
L
V
D
D
E
--
R
W
---
A
R
F
N
E
K
L
E
N
I
E
R
E
R
Q
R
L
K
S
T
W
V
T
P
S
A
E
A
A
A
E
V
N
A
H
L
T
A
P
L
S
R
E
A
S
G
E
D
L
L
R
R
P
E
M
T
Y
E
-------
K
L
T
T
L
T
P
F
A
P
------
A
-
L
T
D
E
Q
A
A
E
Q
V
E
I
Q
V
K
Y
E
G
------------------------------------------------------------------------------
59
HHSearch
84.57
47%
-84
- C4 -
3CES
-
MNMG_ECOLI
A:
[3-550]
Y
P
D
P
F
D
V
I
I
I
G
G
G
H
A
G
T
E
A
A
M
A
A
A
R
M
G
Q
Q
T
L
L
L
T
H
N
I
D
T
---------
L
G
Q
M
S
C
N
P
A
I
G
G
I
G
----
K
G
H
L
V
K
E
V
D
A
L
G
G
L
M
A
K
A
I
D
Q
A
G
I
Q
F
R
I
L
N
A
S
K
G
P
A
V
R
A
T
R
A
Q
A
D
R
V
L
Y
R
Q
A
V
R
T
A
L
E
N
Q
P
N
L
M
I
F
Q
Q
A
V
E
D
L
I
V
E
N
D
R
V
V
G
A
V
T
Q
M
G
L
K
F
R
A
K
A
V
V
L
T
V
G
T
F
L
D
G
K
I
H
I
G
---------------
S
I
P
L
S
R
R
L
R
E
-
L
P
L
R
-
V
G
R
L
K
T
G
T
P
P
R
I
D
A
R
T
I
D
F
S
V
L
A
Q
Q
H
G
D
N
P
M
P
V
F
S
F
-
M
-
G
N
A
S
Q
-
H
P
-------
Q
Q
V
P
C
Y
I
T
H
T
N
-
E
K
T
H
D
V
I
R
S
N
L
D
R
S
---------------
P
S
I
E
D
K
V
------
M
R
F
A
-------------
D
R
N
Q
H
Q
I
F
L
E
P
E
G
L
T
S
N
E
I
Y
P
N
G
I
S
T
S
L
P
F
D
V
Q
M
Q
I
V
R
S
M
Q
G
M
E
N
A
K
I
V
R
P
G
Y
A
I
E
Y
D
F
F
D
-
P
R
D
L
K
P
T
L
E
S
K
F
I
Q
G
L
F
F
A
G
Q
I
N
G
T
T
G
Y
E
E
A
A
A
Q
G
L
L
A
G
L
N
A
A
R
L
S
A
D
K
E
G
W
A
P
A
R
S
Q
A
Y
L
G
V
L
V
D
D
L
C
T
L
G
T
K
E
P
Y
R
M
F
T
S
R
A
E
Y
R
L
M
L
R
E
D
N
A
D
L
R
L
T
E
I
G
R
E
L
G
L
V
D
D
E
--
R
W
---
A
R
F
N
E
K
L
E
N
I
E
R
E
R
Q
R
L
K
S
T
W
V
T
P
S
A
E
A
A
A
E
V
N
A
H
L
T
A
P
L
S
R
E
A
S
G
E
D
L
L
R
R
P
E
M
T
Y
E
-------
K
L
T
T
L
T
P
F
A
P
------
A
L
T
-
D
E
Q
A
A
E
Q
V
E
I
Q
V
K
Y
E
G
------------------------------------------------------------------------------
4
PsiBlast_PDB
84.23
50%
-84
- C4 -
3G05
3
MNMG_ECO57
A:
[34-574]
-----
D
V
I
I
I
G
G
G
H
A
G
T
E
A
A
M
A
A
A
R
M
G
Q
Q
T
L
L
L
T
H
N
I
D
T
---------
L
G
Q
M
S
C
N
P
A
I
G
G
I
G
----
K
G
H
L
V
K
E
V
D
A
L
G
G
L
M
A
K
A
I
D
Q
A
G
I
Q
F
R
I
L
N
A
S
K
G
P
A
V
R
A
T
R
A
Q
A
D
R
V
L
Y
R
Q
A
V
R
T
A
L
E
N
Q
P
N
L
M
I
F
Q
Q
A
V
E
D
L
I
V
E
N
D
R
V
V
G
A
V
T
Q
M
G
L
K
F
R
A
K
A
V
V
L
T
V
G
T
F
L
D
G
K
I
H
I
G
L
D
-------------
S
I
P
L
S
R
R
L
R
E
-
L
P
L
R
-
V
G
R
L
K
T
G
T
P
P
R
I
D
A
R
T
I
D
F
S
V
L
A
Q
Q
H
G
D
N
P
M
P
V
F
S
F
M
G
-
N
A
S
-
Q
-
H
P
-------
Q
Q
V
P
C
Y
I
T
H
T
N
-
E
K
T
H
D
V
I
R
S
N
L
D
R
S
P
--------------
P
S
I
E
D
K
V
------
M
R
F
A
-------------
D
R
N
Q
H
Q
I
F
L
E
P
E
G
L
T
S
N
E
I
Y
P
N
G
I
S
T
S
L
P
F
D
V
Q
M
Q
I
V
R
S
M
Q
G
M
E
N
A
K
I
V
R
P
G
Y
A
I
E
Y
D
F
F
D
-
P
R
D
L
K
P
T
L
E
S
K
F
I
Q
G
L
F
F
A
G
Q
I
N
G
T
T
G
Y
E
E
A
A
A
Q
G
L
L
A
G
L
N
A
A
R
L
S
D
D
K
E
G
W
A
P
A
R
S
Q
A
Y
L
G
V
L
V
D
D
L
C
T
L
G
T
K
E
P
Y
R
M
F
T
S
R
A
E
Y
R
L
M
L
R
E
D
N
A
D
L
R
L
T
E
I
G
R
E
L
G
L
V
D
D
E
--
R
W
---
A
R
F
N
E
K
L
E
N
I
E
R
E
R
Q
R
L
K
S
T
W
V
T
P
S
A
E
A
A
A
E
V
N
A
H
L
T
A
P
L
S
R
E
A
S
G
E
D
L
L
R
R
P
E
M
T
Y
E
-------
K
L
T
T
L
T
P
F
A
P
------
A
-
L
T
D
E
Q
A
A
E
Q
V
E
I
Q
V
K
Y
E
G
------------------------------------------------------------------------------
25
PsiBlast_CBE
83.42
50%
-81
- C4 -
3G05
3
MNMG_ECO57
B:
[34-574]
-----
D
V
I
I
I
G
G
G
H
A
G
T
E
A
A
M
A
A
A
R
M
G
Q
Q
T
L
L
L
T
H
N
I
D
T
---------
L
G
Q
M
S
C
N
P
A
I
G
G
I
G
----
K
G
H
L
V
K
E
V
D
A
L
G
G
L
M
A
K
A
I
D
Q
A
G
I
Q
F
R
I
L
N
A
S
K
G
P
A
V
R
A
T
R
A
Q
A
D
R
V
L
Y
R
Q
A
V
R
T
A
L
E
N
Q
P
N
L
M
I
F
Q
Q
A
V
E
D
L
I
V
E
N
D
R
V
V
G
A
V
T
Q
M
G
L
K
F
R
A
K
A
V
V
L
T
V
G
T
F
L
D
G
K
I
H
I
G
---------------
S
I
P
L
S
R
R
L
R
E
-
L
P
L
R
-
V
G
R
L
K
T
G
T
P
P
R
I
D
A
R
T
I
D
F
S
V
L
A
Q
Q
H
G
D
N
P
M
P
V
F
S
F
M
G
-
N
A
S
-
Q
-
H
P
-------
Q
Q
V
P
C
Y
I
T
H
T
N
-
E
K
T
H
D
V
I
R
S
N
L
D
R
S
---------------
P
S
I
E
D
K
V
------
M
R
F
A
-------------
D
R
N
Q
H
Q
I
F
L
E
P
E
G
L
T
S
N
E
I
Y
P
N
G
I
S
T
S
L
P
F
D
V
Q
M
Q
I
V
R
S
M
Q
G
M
E
N
A
K
I
V
R
P
G
Y
A
I
E
Y
D
F
F
D
-
P
R
D
L
K
P
T
L
E
S
K
F
I
Q
G
L
F
F
A
G
Q
I
N
G
T
T
G
Y
E
E
A
A
A
Q
G
L
L
A
G
L
N
A
A
R
L
S
D
D
K
E
G
W
A
P
A
R
S
Q
A
Y
L
G
V
L
V
D
D
L
C
T
L
G
T
K
E
P
Y
R
M
F
T
S
R
A
E
Y
R
L
M
L
R
E
D
N
A
D
L
R
L
T
E
I
G
R
E
L
G
L
V
D
D
E
--
R
W
---
A
R
F
N
E
K
L
E
N
I
E
R
E
R
Q
R
L
K
S
T
W
V
T
P
S
A
E
A
A
A
E
V
N
A
H
L
T
A
P
L
S
R
E
A
S
G
E
D
L
L
R
R
P
E
M
T
Y
E
-------
K
L
T
T
L
T
P
F
A
P
------
A
-
L
T
D
E
Q
A
A
E
Q
V
E
I
Q
V
K
Y
E
G
------------------------------------------------------------------------------
1
PsiBlast_PDB
82.67
48%
-89
- C4 -
3CP2
1
MNMG_ECOLI
A:
[28-573]
-----
D
V
I
I
I
G
G
G
H
A
G
T
E
A
A
M
A
A
A
R
M
G
Q
Q
T
L
L
L
T
H
N
I
D
T
---------
L
G
Q
M
S
C
N
P
A
I
G
G
I
G
----
K
G
H
L
V
K
E
V
D
A
L
G
G
L
M
A
K
A
I
D
Q
A
G
I
Q
F
R
I
L
N
A
S
K
G
P
A
V
R
A
T
R
A
Q
A
D
R
V
L
Y
R
Q
A
V
R
T
A
L
E
N
Q
P
N
L
M
I
F
Q
Q
A
V
E
D
L
I
V
E
N
D
R
V
V
G
A
V
T
Q
M
G
L
K
F
R
A
K
A
V
V
L
T
V
G
T
F
------------------------
I
P
L
S
R
R
L
R
E
-
L
P
L
R
-
V
G
R
L
K
T
G
T
P
P
R
I
D
A
R
T
I
D
F
S
V
L
A
Q
Q
H
G
D
N
P
M
P
V
F
S
F
-
M
G
N
A
S
-
Q
-
H
P
-------
Q
Q
V
P
C
Y
I
T
H
T
N
------------------------------------------------------------
D
R
N
Q
H
Q
I
F
L
E
P
E
G
L
T
S
N
E
I
Y
P
N
G
I
S
T
S
L
P
F
D
V
Q
M
Q
I
V
R
S
M
Q
G
M
E
N
A
K
I
V
R
P
G
Y
A
I
E
Y
D
F
F
D
-
P
R
D
L
K
P
T
L
E
S
K
F
I
Q
G
L
F
F
A
G
Q
I
N
G
T
T
G
Y
E
E
A
A
A
Q
G
L
L
A
G
L
N
A
A
R
L
S
A
D
K
E
G
W
A
P
A
R
S
Q
A
Y
L
G
V
L
V
D
D
L
C
T
L
G
T
K
E
P
Y
R
M
F
T
S
R
A
E
Y
R
L
M
L
R
E
D
N
A
D
L
R
L
T
E
I
G
R
E
L
G
L
V
D
D
E
--
R
W
---
A
R
F
N
E
K
L
E
N
I
E
R
E
R
Q
R
L
K
S
T
W
V
T
P
S
A
E
A
A
A
E
V
N
A
H
L
T
A
P
L
S
R
E
A
S
G
E
D
L
L
R
R
P
E
M
T
Y
E
-------
K
L
T
T
L
T
P
F
A
P
------
A
-
L
T
D
E
Q
A
A
E
Q
V
E
I
Q
V
K
Y
E
G
Y
I
A
---------------------------------------------------------------------------
62
HHSearch
49.96
25%
-68
- C4 -
3G5S
8
TRMFO_THET8
A:
[1-426]
---
M
E
R
V
N
V
V
G
A
G
L
A
G
S
E
A
A
W
T
L
L
R
L
G
V
P
V
R
L
F
E
M
R
P
K
R
MTPAHGTDR
F
A
E
I
V
C
S
N
S
L
G
G
E
G
ETN
A
K
G
L
L
Q
A
E
M
R
R
A
G
S
L
V
M
E
A
A
D
L
A
R
V
----------
P
--
A
G
G
A
L
A
V
D
R
E
E
F
S
G
Y
I
T
E
R
L
T
G
H
P
L
L
------------------
E
V
V
R
E
E
V
R
E
I
P
P
G
I
T
V
L
A
T
G
P
L
T
S
----------------------
E
A
L
A
E
A
L
K
R
R
F
G
D
H
-
F
L
A
Y
Y
D
A
A
S
P
I
V
L
Y
E
S
I
D
L
T
K
C
F
R
A
G
R
Y
---------------------------
Y
L
N
C
P
M
T
E
E
E
Y
R
R
F
H
Q
A
L
L
E
A
Q
R
H
T
P
H
---------
F
E
A
C
V
P
V
E
E
L
A
R
R
GYQ
T
L
L
F
G
PMKPVGLVDPRTG
K
E
P
F
A
V
V
Q
L
R
Q
E
D
K
A
G
R
M
W
S
L
V
G
F
Q
T
G
L
K
W
P
E
Q
K
R
L
I
Q
M
I
P
G
L
E
N
A
E
I
V
R
Y
G
V
M
H
R
N
T
Y
L
N
A
P
R
L
L
G
E
T
L
E
F
R
E
A
E
G
L
Y
A
A
G
V
L
A
G
V
E
G
Y
L
E
S
A
A
T
G
F
L
A
G
L
N
A
A
R
K
A
L
G
L
P
P
V
A
P
-
P
E
E
S
M
L
G
G
L
V
R
Y
L
A
T
A
N
P
E
G
F
Q
P
M
-----------------------
Y
A
N
W
G
L
V
P
P
V
EG
R
M
---
G
K
K
E
K
R
Q
A
M
Y
R
R
G
L
E
A
F
S
A
W
L
S
G
L
N
P
P
L
P
------------------------------------------------------------------------------------------------------------------------------------------------------
9
PsiBlast_PDB
40.96
26%
-66
- C4 -
2CUL
1
?
A:
[5-163]
-----
Q
V
L
I
V
G
A
G
F
S
G
A
E
T
A
F
W
L
A
Q
K
G
V
R
V
G
L
L
T
Q
S
L
D
A
---------
V
M
M
P
F
L
P
P
K
P
P
F
P
P
----
G
S
L
L
E
R
A
Y
D
----------------------
P
K
D
E
R
V
W
A
F
H
A
R
---------
A
K
Y
L
L
E
G
L
R
P
L
H
L
F
Q
A
T
A
T
G
L
L
L
E
G
N
R
V
V
G
V
R
T
W
E
G
P
P
A
R
G
E
K
V
V
L
A
V
G
S
F
L
G
A
R
L
F
L
G
G
V
V
E
E
A
G
R
-
L
-
S
E
A
S
Y
P
D
L
L
E
D
L
S
R
-
L
G
F
R
F
V
E
R
E
G
E
V
P
P
G
Y
R
V
R
Y
L
A
F
H
P
E
E
W
E
E
K
T
F
R
L
K
R
L
E
G
L
-
Y
-
A
V
G
-
L
-
C
V
-------
R
E
G
D
Y
A
R
M
S
E
E
-
G
K
R
L
A
E
H
L
L
H
E
L
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
75
HHSearch
36.89
35%
-87
- C4 -
2R9Z
2
GASHR_MARGR
A:
[2-37]
-
T
Q
H
F
D
L
I
A
I
G
G
G
S
G
G
L
A
V
A
E
K
A
A
A
F
G
K
R
V
A
L
I
E
S
K
A
L
G
---------
G
T
C
V
N
V
G
C
V
P
K
K
V
M
----
W
Y
A
S
H
L
A
E
A
V
R
D
A
P
G
F
G
V
Q
A
S
L
D
W
P
R
L
V
A
G
R
D
R
Y
I
G
A
I
N
S
F
W
D
G
Y
V
E
R
L
G
I
T
R
V
D
G
H
A
R
F
V
D
A
H
T
I
E
V
E
G
Q
R
L
S
A
D
H
I
V
I
A
T
G
G
R
P
I
V
P
R
L
P
G
A
E
L
G
I
T
S
D
G
F
F
A
L
Q
Q
Q
P
K
R
V
A
I
I
G
A
G
-
Y
-
I
G
I
E
L
A
G
L
L
R
S
F
G
S
-
E
V
T
V
-
V
A
L
E
D
R
L
L
F
Q
F
D
P
L
L
S
A
T
L
A
E
N
M
H
A
Q
G
I
E
T
H
L
E
F
A
V
-
A
-
A
L
E
-
R
-
D
A
-------
Q
G
T
T
L
V
A
Q
D
G
T
-
R
L
E
G
F
D
S
V
I
W
A
V
G
R
A
P
N
T
R
D
L
G
L
E
A
A
G
I
E
V
Q
S
N
G
M
V
------
P
T
D
A
-------------
Y
Q
N
T
N
V
P
G
V
Y
A
L
G
D
I
T
G
R
D
Q
L
T
P
V
A
I
A
A
G
R
R
L
A
E
R
L
F
D
G
Q
S
E
R
K
L
D
Y
D
N
I
P
T
V
V
F
A
H
P
P
L
S
-
K
V
G
L
S
E
P
E
A
R
E
R
L
G
D
V
L
T
V
Y
E
T
S
F
T
P
M
R
Y
A
L
N
E
H
G
P
K
T
A
M
K
L
V
C
A
G
P
E
Q
R
V
V
G
V
H
V
I
G
D
G
A
D
E
M
L
Q
G
F
A
V
A
V
K
M
G
A
T
K
A
D
F
D
N
T
V
A
I
H
P
G
S
A
E
E
L
V
T
L
K
E
P
V
R
R
P
G
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
11
PsiBlast_PDB
36.15
41%
-44
- C4 -
3L8K
-
?
A:
[174-204]
-----
D
M
V
I
I
G
A
G
Y
I
G
L
E
I
A
S
I
F
R
L
M
G
V
Q
T
H
I
I
E
M
L
D
R
A
---------
L
I
T
L
E
D
Q
D
I
V
N
T
L
L
----
S
I
L
K
L
N
I
K
F
N
S
P
V
T
E
V
K
K
I
K
D
D
E
Y
E
V
I
Y
S
T
K
D
G
S
K
K
S
I
F
T
N
S
V
V
L
A
A
G
R
R
P
V
I
P
E
G
A
R
E
I
G
L
S
I
S
K
T
G
I
V
V
D
E
T
M
K
T
N
I
P
N
V
F
A
T
G
D
A
N
G
L
A
P
Y
Y
H
A
A
V
R
M
S
I
A
A
A
N
N
I
M
A
N
G
M
P
V
D
Y
V
-
D
-
V
K
S
I
P
V
T
I
Y
T
I
P
S
L
-
S
Y
V
G
-
I
L
P
S
K
A
R
K
M
G
I
E
I
V
E
A
E
Y
N
M
E
E
D
V
S
A
Q
I
Y
G
Q
K
E
G
V
L
-
K
-
L
I
F
-
E
-
R
G
-------
S
M
R
L
I
G
A
W
M
I
G
-
V
H
S
Q
Y
L
I
N
E
L
G
L
A
V
A
Y
G
L
N
A
K
Q
L
A
S
F
A
E
Q
H
P
S
T
N
E
I
------
I
S
Y
T
-------------
A
R
K
V
I
E
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
80
HHSearch
36.14
32%
-68
* C4 *
1ONF
1
GSHR_PLAFK
A:
[2-34]
---
V
Y
D
L
I
V
I
G
G
G
S
G
G
M
A
A
A
R
R
A
A
R
H
N
A
K
V
A
L
V
E
K
S
R
L
G
---------
G
T
C
V
N
V
G
C
V
P
K
K
I
M
----
F
N
A
A
S
V
H
D
I
L
E
N
S
R
H
Y
G
F
D
T
K
F
S
F
N
L
P
L
L
V
E
R
R
D
K
Y
I
Q
R
L
N
N
I
Y
R
Q
N
L
S
K
D
K
V
D
L
Y
E
G
T
A
S
F
L
E
G
R
N
I
L
I
A
V
G
N
K
P
V
F
P
P
V
K
G
I
E
N
T
I
S
S
D
E
F
F
N
I
K
E
S
K
K
I
G
I
V
G
S
G
Y
I
A
V
E
L
I
N
V
I
K
-
R
-
L
G
I
D
S
Y
I
F
A
R
G
N
R
I
-
L
R
K
F
-
D
E
S
V
I
N
V
L
E
N
D
M
K
K
N
N
I
N
I
V
T
F
A
D
V
V
E
I
K
K
V
S
D
K
N
L
-
S
-
I
H
L
-
S
-
D
G
-------
R
I
Y
E
H
F
D
H
V
I
Y
-
C
V
G
R
S
P
D
T
E
N
L
K
L
E
K
L
N
V
E
T
N
N
N
Y
I
V
V
D
E
N
Q
R
T
S
V
N
------
N
I
Y
A
-------------
V
G
D
C
C
M
V
K
F
Y
N
V
Q
L
T
P
V
A
I
N
A
G
R
L
L
A
D
R
L
F
L
K
K
T
R
K
T
N
Y
K
L
I
P
T
V
I
F
S
H
P
P
I
G
T
I
G
L
S
E
E
A
-
A
I
Q
I
Y
G
K
E
N
V
K
I
Y
E
S
K
F
T
N
L
F
F
S
V
Y
D
I
E
P
E
L
K
E
K
T
Y
L
K
L
V
C
V
G
K
D
E
L
I
K
G
L
H
I
I
G
L
N
A
D
E
I
V
Q
G
F
A
V
A
L
K
M
N
A
T
K
K
D
F
D
E
T
I
P
I
H
P
T
A
A
E
E
F
L
T
L
Q
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------