@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : jhp_0560: (2015-12-16 )
MRSHFCTEISEKDVGKTIKVAGWCNTYRDHGGVVFIDLRDKSGLVQLVCDPSSKAYEKALEVRSEFVLVAKGKARLRGAGLENPKLKTGKIEIVLEELVIENKSATPPIEIGNKSVNEDLRLKYRYLDLRSLNAYEIFKLRSEVALITRNALAQKGFLEIETPILSKTTPEGARDYLVPSRVHEGEFFALPQSPQLFKQLLMVGGMDRYFQIARCFRDEDLRADRQPEFTQIDAEMSFCDEDDVMGVVEDLLQEIFKAIGHTISKPFKRMPYKEAMENYGSDKPDLRFELPLIEVGDCFMDSSNSIFSNIAQDPKDKRIKALNVKGADAVFSRSVLKELEEFVRQFGAKGLAYLQIKEDGIKGPLVKFLSEKGLKNILERTDAQVGDIVFFGAGDKKIVLDYMGRLRLKVAETLDLIDKDALNFLWVVHFPMFEKTENGYHAAHHPFTMPKNIECEDIEEIEAHAYDVVLNGVELGGGSIRIHKEEMQKKVFEKININEEEAQKKFGFLLEALKFGAPPHGGFAIGFDRLIMLMTKSNSIRDVIAFPKTQKASCLLTDAPSPINEEQLRELHIRLRKPI
Atome Classification :
(20 SA)
.........10........20........30........40........--50.-.----......60.........70........80........90........100..-....--.110..------------------------..-....-----120.......130.......140.......150..-.....160.......170.......180.......190.......200.......210.......220....-...230.......-240.......250.....-..-260---------------........270.......280.......290.......300.......310.......320.......330.......340..-.....350......-----.360---.........370.......380.......390.......400.......410...-----....420.......430.---.--..--.------------..-440.-.....-.450---......----.----.460--...--.-------.....470.......480.......490.......500.......510.......520.......530.......540.......550.......560.......570.......
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MRSHFC
T
E
I
S
E
KDVG
K
T
I
K
V
A
G
W
CNTYRDHG
G
V
V
F
I
D
LRDKS
G
L
V
Q
L
V
C--DPS-
S
----
K
A
Y
E
K
A
L
-
E
V
R
S
E
F
V
L
V
AKGK
A
R
L
RGAGLENPKLKTG
K
I
E
I
V
L
E
E
L
V
IENKS-ATPP--IEI-GN------------------------KS-VNE
D
-----
L
R
L
K
Y
R
Y
L
D
LRSL
N
A
Y
E
I
F
K
L
R
S
E
V
A
L
I
T
R
N
A
L
AQ-KG
F
L
E
IETPILSKTTPEGARDYLVPSRVHEG
E
F
F
ALPQ
S
P
Q
L
F
K
Q
L
L
M
VGG
M
D
R
Y
F
Q
I
A
R
C
F
R
D
EDLRADRQ-PE
F
T
Q
IDAEMSFC-DE
D
D
V
M
G
V
V
E
D
L
L
Q
E
I
F
K
-
A
I
-
G
H
----------------
T
I
S
K
P
F
KRM
P
Y
K
E
A
M
E
NYGSDKPD
L
R
F
ELPLIEV
G
D
C
FMDSS
N
S
I
F
S
N
I
AQDPKDK
R
I
K
A
L
NVK
G
A
D
A
V
F
S
R
S
V
L
K
E
L
E
E
F
V
R
-
Q
FGAK
G
L
A
Y
L
Q
I
KE-----DG-----IK
G
P
L
V
K
F
L
S
E
K
G
L
K
N
I
L
E
R
TDAQVG
D
I
V
F
FGAGD
K
K
I
V
L
D
Y
M
G
R
L
R
L
K
V
A
E
T
L
D
-----
L
I
D
K
DA
L
N
F
L
W
V
V
HFPMF---E--KT--E------------NG-YHAA-HHPFT-MPK----NIE
C
E
D
----
I
----
E
E
----
I
E
A
--
H
-------
A
Y
D
V
V
L
N
G
V
E
LGG
G
S
I
R
I
H
K
E
E
M
Q
K
K
V
F
E
KINI
N
E
E
E
A
Q
K
K
F
G
F
L
L
E
A
L
KFGAPPHG
G
F
A
I
G
F
D
R
L
I
M
LMTKSNSI
R
D
VIAFPKTQK
A
S
C
L
L
TDAPSPI
N
E
E
Q
L
R
E
L
H
I
R
LRKPI
1
PsiBlast_PDB
94.65
51%
-99
- C5 -
4WJ3
-
SYDND_PSEAE
M:
[10-594]
M
R
S
H
Y
C
G
Q
L
N
E
S
L
D
G
Q
E
V
T
L
C
G
W
V
H
R
R
R
D
H
G
G
V
I
F
L
D
V
R
D
R
E
G
L
A
Q
V
V
F
--
D
P
D
R
A
----
E
T
F
A
K
A
D
-
R
V
R
S
E
F
V
V
K
I
T
G
K
V
R
L
R
P
E
G
A
R
N
P
N
M
A
S
G
S
I
E
V
L
G
Y
E
L
E
V
L
N
Q
A
-
E
T
P
P
--
F
P
L
-
D
E
------------------------
Y
S
D
V
G
E
E
-----
T
R
L
R
Y
R
F
I
D
L
R
R
P
E
M
A
A
K
L
K
L
R
A
R
I
T
S
S
I
R
R
Y
L
D
D
-
N
G
F
L
D
V
E
T
P
I
L
G
R
P
T
P
E
G
A
R
D
Y
L
V
P
S
R
T
Y
P
G
H
F
F
A
L
P
Q
S
P
Q
L
F
K
Q
L
L
M
V
A
G
F
D
R
Y
Y
Q
I
A
K
C
F
R
D
E
D
L
R
A
D
R
Q
-
P
E
F
T
Q
I
D
I
E
T
S
F
L
-
D
E
S
D
I
I
G
I
T
E
K
M
V
R
Q
L
F
K
-
E
V
-
L
D
----------------
V
E
F
D
E
F
P
H
M
P
F
E
E
A
M
R
R
Y
G
S
D
K
P
D
L
R
I
P
L
E
L
V
D
V
A
D
Q
L
K
E
V
E
F
K
V
F
S
G
P
A
N
D
P
K
-
G
R
V
A
A
L
R
V
P
G
A
-
A
S
M
P
R
S
Q
I
D
D
Y
T
K
F
V
G
-
I
Y
G
A
K
G
L
A
Y
I
K
V
N
E
RAKGV
E
G
-----
L
Q
S
P
I
V
K
F
I
P
E
A
N
L
N
V
I
L
D
R
V
G
A
V
D
G
D
I
V
F
F
G
A
D
K
A
K
I
V
C
D
A
L
G
A
L
R
I
K
V
G
H
D
L
K
-----
L
L
T
R
E
W
A
P
-
M
W
V
V
D
F
P
M
F
---
E
--
E
N
--
D
------------
D
G
-
S
L
S
A
L
H
H
P
F
T
-
S
P
K
----
C
T
P
A
------------
E
----
L
E
A
--
N
PGAALSR
A
Y
D
M
V
L
N
G
T
E
L
G
G
G
S
I
R
I
H
D
K
S
M
Q
Q
A
V
F
R
V
L
G
I
D
E
A
E
Q
E
E
K
F
G
F
L
L
D
A
L
K
Y
G
A
P
P
H
G
G
L
A
F
G
L
D
R
L
V
M
L
M
T
G
A
S
S
I
R
E
V
I
A
F
P
K
T
Q
S
A
G
D
V
M
T
Q
A
P
G
S
V
D
G
K
A
L
R
E
L
H
I
R
L
R
E
Q
P
3
PsiBlast_PDB
94.26
48%
-98
- C5 -
1C0A
2
SYD_ECOLI
A:
[1-585]
M
R
T
E
Y
C
G
Q
L
R
L
S
H
V
G
Q
Q
V
T
L
C
G
W
V
N
R
R
R
D
L
G
S
L
I
F
I
D
M
R
D
R
E
G
I
V
Q
V
F
F
--
D
P
D
R
A
----
D
A
L
K
L
A
S
-
E
L
R
N
E
F
C
I
Q
V
T
G
T
V
R
A
R
D
E
K
N
I
N
R
D
M
A
T
G
E
I
E
V
L
A
S
S
L
T
I
I
N
R
A
-
D
V
L
P
--
L
D
--
S
N
------------------------
H
V
-
N
T
E
E
-----
A
R
L
K
Y
R
Y
L
D
L
R
R
P
E
M
A
Q
R
L
K
T
R
A
K
I
T
S
L
V
R
R
F
M
D
D
-
H
G
F
L
D
I
E
T
P
M
L
T
K
A
T
P
E
G
A
R
D
Y
L
V
P
S
R
V
H
K
G
K
F
Y
A
L
P
Q
S
P
Q
L
F
K
Q
L
L
M
M
S
G
F
D
R
Y
Y
Q
I
V
K
C
F
R
D
E
D
L
R
A
D
R
Q
-
P
E
F
T
Q
I
D
V
E
T
S
F
M
-
T
A
P
Q
V
R
E
V
M
E
A
L
V
R
H
L
W
L
-
E
V
-
K
G
----------------
V
D
L
G
D
F
P
V
M
T
F
A
E
A
E
R
R
Y
G
S
D
K
P
D
L
R
N
P
M
E
L
T
D
V
A
D
L
L
K
S
V
E
F
A
V
F
A
G
P
A
N
D
P
K
-
G
R
V
A
A
L
R
V
P
G
G
-
A
S
L
T
R
K
Q
I
D
E
Y
G
N
F
V
K
-
I
Y
G
A
K
G
L
A
Y
I
K
V
N
E
RAKGL
E
G
-----
I
N
S
P
V
A
K
F
L
N
A
E
I
I
E
D
I
L
D
R
T
A
A
Q
D
G
D
M
I
F
F
G
A
D
N
K
K
I
V
A
D
A
M
G
A
L
R
L
K
V
G
K
D
L
G
-----
L
T
D
E
S
K
W
A
P
L
W
V
I
D
F
P
M
F
---
E
--
D
D
G-
E
------------
G
G
-
L
T
A
M
-
H
H
P
F
T
-
S
P
K
----
D
M
T
A
A
E
----
L
K
A
AP
E
N
----
A
V
A
--
N
-------
A
Y
D
M
V
I
N
G
Y
E
V
G
G
G
S
V
R
I
H
N
G
D
M
Q
Q
T
V
F
G
I
L
G
I
N
E
E
E
Q
R
E
K
F
G
F
L
L
D
A
L
K
Y
G
T
P
P
H
A
G
L
A
F
G
L
D
R
L
T
M
L
L
T
G
T
D
N
I
R
D
V
I
A
F
P
K
T
T
A
A
A
C
L
M
T
E
A
P
S
F
A
N
P
T
A
L
A
E
L
S
I
Q
V
V
K
--
23
PsiBlast_CBE
94.12
48%
-98
- C5 -
1EQR
1
SYD_ECOLI
B:
[1-585]
M
R
T
E
Y
C
G
Q
L
R
L
S
H
V
G
Q
Q
V
T
L
C
G
W
V
N
R
R
R
D
L
G
S
L
I
F
I
D
M
R
D
R
E
G
I
V
Q
V
F
F
--
D
P
D
R
A
----
D
A
L
K
L
A
S
-
E
L
R
N
E
F
C
I
Q
V
T
G
T
V
R
A
R
D
E
K
N
I
N
R
D
M
A
T
G
E
I
E
V
L
A
S
S
L
T
I
I
N
R
A
-
D
V
L
P
--
L
D
--
S
N
------------------------
H
V
-
N
T
E
E
-----
A
R
L
K
Y
R
Y
L
D
L
R
R
P
E
M
A
Q
R
L
K
T
R
A
K
I
T
S
L
V
R
R
F
M
D
D
-
H
G
F
L
D
I
E
T
P
M
L
T
K
A
T
P
E
G
A
R
D
Y
L
V
P
S
R
V
H
K
G
K
F
Y
A
L
P
Q
S
P
Q
L
F
K
Q
L
L
M
M
S
G
F
D
R
Y
Y
Q
I
V
K
C
F
R
D
E
D
L
R
A
D
R
Q
-
P
E
F
T
Q
I
D
V
E
T
S
F
M
-
T
A
P
Q
V
R
E
V
M
E
A
L
V
R
H
L
W
L
-
E
V
-
K
G
----------------
V
D
L
G
D
F
P
V
M
T
F
A
E
A
E
R
R
Y
G
S
D
K
P
D
L
R
N
P
M
E
L
T
D
V
A
D
L
L
K
S
V
E
F
A
V
F
A
G
P
A
N
D
P
K
-
G
R
V
A
A
L
R
V
P
G
G
-
A
S
L
T
R
K
Q
I
D
E
Y
G
N
F
V
K
-
I
Y
G
A
K
G
L
A
Y
I
K
V
N
E
RAKGL
E
G
-----
I
N
S
P
V
A
K
F
L
N
A
E
I
I
E
D
I
L
D
R
T
A
A
Q
D
G
D
M
I
F
F
G
A
D
N
K
K
I
V
A
D
A
M
G
A
L
R
L
K
V
G
K
D
L
G
-----
L
T
D
E
S
K
W
A
P
L
W
V
I
D
F
P
M
F
---
E
--
D
D
G-
E
------------
G
G
-
L
T
A
M
-
H
H
P
F
T
-
S
P
K
----
D
M
T
A
A
E
----
L
KAAP
E
N
----
A
V
A
--
N
-------
A
Y
D
M
V
I
N
G
Y
E
V
G
G
G
S
V
R
I
H
N
G
D
M
Q
Q
T
V
F
G
I
L
G
I
N
E
E
E
Q
R
E
K
F
G
F
L
L
D
A
L
K
Y
G
T
P
P
H
A
G
L
A
F
G
L
D
R
L
T
M
L
L
T
G
T
D
N
I
R
D
V
I
A
F
P
K
T
T
A
A
A
C
L
M
T
E
A
P
S
F
A
N
P
T
A
L
A
E
L
S
I
Q
V
V
K
K
A
4
PsiBlast_PDB
93.54
48%
-97
- C5 -
1EQR
1
SYD_ECOLI
A:
[1-585]
M
R
T
E
Y
C
G
Q
L
R
L
S
H
V
G
Q
Q
V
T
L
C
G
W
V
N
R
R
R
D
L
G
S
L
I
F
I
D
M
R
D
R
E
G
I
V
Q
V
F
F
--
D
P
D
R
A
----
D
A
L
K
L
A
S
-
E
L
R
N
E
F
C
I
Q
V
T
G
T
V
R
A
R
D
E
K
N
I
N
R
D
M
A
T
G
E
I
E
V
L
A
S
S
L
T
I
I
N
R
A
-
D
V
L
P
--
L
D
--
S
N
------------------------
H
V
-
N
T
E
E
-----
A
R
L
K
Y
R
Y
L
D
L
R
R
P
E
M
A
Q
R
L
K
T
R
A
K
I
T
S
L
V
R
R
F
M
D
D
-
H
G
F
L
D
I
E
T
P
M
L
T
K
A
T
P
E
G
A
R
D
Y
L
V
P
S
R
V
H
K
G
K
F
Y
A
L
P
Q
S
P
Q
L
F
K
Q
L
L
M
M
S
G
F
D
R
Y
Y
Q
I
V
K
C
F
R
D
E
D
L
R
A
D
R
Q
-
P
E
F
T
Q
I
D
V
E
T
S
F
M
-
T
A
P
Q
V
R
E
V
M
E
A
L
V
R
H
L
W
L
-
E
V
-
K
G
----------------
V
D
L
G
D
F
P
V
M
T
F
A
E
A
E
R
R
Y
G
S
D
K
P
D
L
R
N
P
M
E
L
T
D
V
A
D
L
L
K
S
V
E
F
A
V
F
A
G
P
A
N
D
P
K
-
G
R
V
A
A
L
R
V
P
G
G
-
A
S
L
T
R
K
Q
I
D
E
Y
G
N
F
V
K
-
I
Y
G
A
K
G
L
A
Y
I
K
V
N
E
RAKGL
E
G
-----
I
N
S
P
V
A
K
F
L
N
A
E
I
I
E
D
I
L
D
R
T
A
A
Q
D
G
D
M
I
F
F
G
A
D
N
K
K
I
V
A
D
A
M
G
A
L
R
L
K
V
G
K
D
L
G
-----
L
T
D
E
S
K
W
A
P
L
W
V
I
D
F
P
M
F
---
E
--
D
D
G-
E
------------
G
G
-
L
T
A
M
-
H
H
P
F
T
-
S
P
K
----
D
M
T
A
A
E
----
L
K
A
AP
E
N
----
A
V
A
--
N
-------
A
Y
D
M
V
I
N
G
Y
E
V
G
G
G
S
V
R
I
H
N
G
D
M
Q
Q
T
V
F
G
I
L
G
I
N
E
E
E
Q
R
E
K
F
G
F
L
L
D
A
L
K
Y
G
T
P
P
H
A
G
L
A
F
G
L
D
R
L
T
M
L
L
T
G
T
D
N
I
R
D
V
I
A
F
P
K
T
T
A
A
A
C
L
M
T
E
A
P
S
F
A
N
P
T
A
L
A
E
L
S
I
Q
V
V
K
K
A
5
PsiBlast_PDB
93.38
48%
-99
- C5 -
1IL2
2
SYD_ECOLI
A:
[1-585]
M
R
T
E
Y
C
G
Q
L
R
L
S
H
V
G
Q
Q
V
T
L
C
G
W
V
N
R
R
R
D
L
G
S
L
I
F
I
D
M
R
D
R
E
G
I
V
Q
V
F
F
--
D
P
D
R
A
----
D
A
L
K
L
A
S
-
E
L
R
N
E
F
C
I
Q
V
T
G
T
V
R
A
R
D
E
K
N
I
N
R
D
M
A
T
G
E
I
E
V
L
A
S
S
L
T
I
I
N
R
A
-
D
V
L
P
--
L
D
--
S
N
------------------------
H
V
-
N
T
E
E
-----
A
R
L
K
Y
R
Y
L
D
L
R
R
P
E
M
A
Q
R
L
K
T
R
A
K
I
T
S
L
V
R
R
F
M
D
D
-
H
G
F
L
D
I
E
T
P
M
L
T
K
A
T
P
E
G
A
R
D
Y
L
V
P
S
R
V
H
K
G
K
F
Y
A
L
P
Q
S
P
Q
L
F
K
Q
L
L
M
M
S
G
F
D
R
Y
Y
Q
I
V
K
C
F
R
D
E
D
L
R
A
D
R
Q
-
P
E
F
T
Q
I
D
V
E
T
S
F
M
-
T
A
P
Q
V
R
E
V
M
E
A
L
V
R
H
L
W
L
-
E
V
-
K
G
----------------
V
D
L
G
D
F
P
V
M
T
F
A
E
A
E
R
R
Y
G
S
D
K
P
D
L
R
N
P
M
E
L
T
D
V
A
D
L
L
K
S
V
E
F
A
V
F
A
G
P
A
N
D
P
K
-
G
R
V
A
A
L
R
V
P
G
G
-
A
S
L
T
R
K
Q
I
D
E
Y
G
N
F
V
K
-
I
Y
G
A
K
G
L
A
Y
I
K
V
N
E
RAKGL
E
G
-----
I
N
S
P
V
A
K
F
L
N
A
E
I
I
E
D
I
L
D
R
T
A
A
Q
D
G
D
M
I
F
F
G
A
D
N
K
K
I
V
A
D
A
M
G
A
L
R
L
K
V
G
K
D
L
G
-----
L
T
D
E
S
K
W
A
P
L
W
V
I
D
F
P
M
F
---
E
--
D
D
G-
E
------------
G
G
-
L
T
A
M
-
H
H
P
F
T
-
S
P
K
----
D
M
T
A
A
E
----
L
K
A
AP
E
N
----
A
V
A
--
N
-------
A
Y
D
M
V
I
N
G
Y
E
V
G
G
G
S
V
R
I
H
N
G
D
M
Q
Q
T
V
F
G
I
L
G
I
N
E
E
E
Q
R
E
K
F
G
F
L
L
D
A
L
K
Y
G
T
P
P
H
A
G
L
A
F
G
L
D
R
L
T
M
L
L
T
G
T
D
N
I
R
D
V
I
A
F
P
K
T
T
A
A
A
C
L
M
T
E
A
P
S
F
A
N
P
T
A
L
A
E
L
S
I
Q
V
V
K
--
21
PsiBlast_CBE
92.42
48%
-97
- C5 -
1IL2
2
SYD_ECOLI
B:
[1-585]
M
R
T
E
Y
C
G
Q
L
R
L
S
H
V
G
Q
Q
V
T
L
C
G
W
V
N
R
R
R
D
L
G
S
L
I
F
I
D
M
R
D
R
E
G
I
V
Q
V
F
F
--
D
P
D
R
A
----
D
A
L
K
L
A
S
-
E
L
R
N
E
F
C
I
Q
V
T
G
T
V
R
A
R
D
E
K
N
I
N
R
D
M
A
T
G
E
I
E
V
L
A
S
S
L
T
I
I
N
R
A
-
D
V
L
P
--
L
D
--
S
N
------------------------
H
V
-
N
T
E
E
-----
A
R
L
K
Y
R
Y
L
D
L
R
R
P
E
M
A
Q
R
L
K
T
R
A
K
I
T
S
L
V
R
R
F
M
D
D
-
H
G
F
L
D
I
E
T
P
M
L
T
K
A
T
P
E
G
A
R
D
Y
L
V
P
S
R
V
H
K
G
K
F
Y
A
L
P
Q
S
P
Q
L
F
K
Q
L
L
M
M
S
G
F
D
R
Y
Y
Q
I
V
K
C
F
R
D
E
D
L
R
A
D
R
Q
-
P
E
F
T
Q
I
D
V
E
T
S
F
M
-
T
A
P
Q
V
R
E
V
M
E
A
L
V
R
H
L
W
L
-
E
V
-
K
G
----------------
V
D
L
G
D
F
P
V
M
T
F
A
E
A
E
R
R
Y
G
S
D
K
P
D
L
R
N
P
M
E
L
T
D
V
A
D
L
L
K
S
V
E
F
A
V
F
A
G
P
A
N
D
P
K
-
G
R
V
A
A
L
R
V
P
G
G
-
A
S
L
T
R
K
Q
I
D
E
Y
G
N
F
V
K
-
I
Y
G
A
K
G
L
A
Y
I
K
V
N
E
RAKGL
E
G
-----
I
N
S
P
V
A
K
F
L
N
A
E
I
I
E
D
I
L
D
R
T
A
A
Q
D
G
D
M
I
F
F
G
A
D
N
K
K
I
V
A
D
A
M
G
A
L
R
L
K
V
G
K
D
L
G
-----
L
T
D
E
S
K
W
A
P
L
W
V
I
D
F
P
M
F
---
E
--
D
D
G-
E
------------
G
G
-
L
T
A
M
-
H
H
P
F
T
-
S
P
K
----
D
M
T
A
A
E
----
L
KAAP
E
N
----
A
V
A
--
N
-------
A
Y
D
M
V
I
N
G
Y
E
V
G
G
G
S
V
R
I
H
N
G
D
M
Q
Q
T
V
F
G
I
L
G
I
N
E
E
E
Q
R
E
K
F
G
F
L
L
D
A
L
K
Y
G
T
P
P
H
A
G
L
A
F
G
L
D
R
L
T
M
L
L
T
G
T
D
N
I
R
D
V
I
A
F
P
K
T
T
A
A
A
C
L
M
T
E
A
P
S
F
A
N
P
T
A
L
A
E
L
S
I
Q
V
V
K
--
72
Fugue
92.26
48%
-95
- C5 -
1C0A
2
SYD_ECOLI
A:
[1-585]
M
R
T
E
Y
C
G
Q
L
R
L
S
H
V
G
Q
Q
V
T
L
C
G
W
V
N
R
R
R
D
L
G
S
L
I
F
I
D
M
R
D
R
E
G
I
V
Q
V
F
F
D
-
P
D
R
-
A
----
D
A
L
K
L
A
S
-
E
L
R
N
E
F
C
I
Q
V
T
G
T
V
R
A
R
D
E
K
N
I
N
R
D
M
A
T
G
E
I
E
V
L
A
S
S
L
T
I
I
N
R
A
-
D
V
L
P
--
L
D
S
-
N
H
------------------------
V
N
--
T
E
E
-----
A
R
L
K
Y
R
Y
L
D
L
R
R
P
E
M
A
Q
R
L
K
T
R
A
K
I
T
S
L
V
R
R
F
M
D
D
-
H
G
F
L
D
I
E
T
P
M
L
T
K
A
T
P
E
G
A
R
D
Y
L
V
P
S
R
V
H
K
G
K
F
Y
A
L
P
Q
S
P
Q
L
F
K
Q
L
L
M
M
S
G
F
D
R
Y
Y
Q
I
V
K
C
F
R
D
E
D
L
R
A
D
R
Q
-
P
E
F
T
Q
I
D
V
E
T
S
F
M
-
T
A
P
Q
V
R
E
V
M
E
A
L
V
R
H
L
W
L
-
E
V
-
K
G
----------------
V
D
L
G
D
F
P
V
M
T
F
A
E
A
E
R
R
Y
G
S
D
K
P
D
L
R
N
P
M
E
L
T
D
V
A
D
L
L
K
S
V
E
F
A
V
F
A
G
P
A
N
D
P
-
K
G
R
V
A
A
L
R
V
P
G
G
A
S
-
L
T
R
K
Q
I
D
E
Y
G
N
F
V
K
-
I
Y
G
A
K
G
L
A
Y
I
K
V
N
E
-----
R
A
KGLEG
I
N
S
P
V
A
K
F
L
N
A
E
I
I
E
D
I
L
D
R
T
A
A
Q
D
G
D
M
I
F
F
G
A
D
N
K
K
I
V
A
D
A
M
G
A
L
R
L
K
V
G
K
D
L
G
-----
L
T
D
E
S
K
W
A
P
L
W
V
I
D
F
P
M
F
---
E
--
D
D
--
G
------------
E
G
G
L
T
A
M
-
H
H
P
F
T
-
S
P
K
----
D
M
T
A
A
E
----
L
----
K
A
APEN
A
V
A
--
N
-------
A
Y
D
M
V
I
N
G
Y
E
V
G
G
G
S
V
R
I
H
N
G
D
M
Q
Q
T
V
F
G
I
L
G
I
N
E
E
E
Q
R
E
K
F
G
F
L
L
D
A
L
K
Y
G
T
P
P
H
A
G
L
A
F
G
L
D
R
L
T
M
L
L
T
G
T
D
N
I
R
D
V
I
A
F
P
K
T
T
A
A
A
C
L
M
T
E
A
P
S
F
A
N
P
T
A
L
A
E
L
S
I
Q
V
V
K
--
2
PsiBlast_PDB
92.26
51%
-93
- C5 -
4WJ4
1
SYDND_PSEAE
A:
[10-594]
M
R
S
H
Y
C
G
Q
L
N
E
S
L
D
G
Q
E
V
T
L
C
G
W
V
H
R
R
R
D
H
G
G
V
I
F
L
D
V
R
D
R
E
G
L
A
Q
V
V
F
--
D
P
D
R
A
----
E
T
F
A
K
A
D
-
R
V
R
S
E
F
V
V
K
I
T
G
K
V
R
L
R
P
E
G
A
R
N
P
N
M
A
S
G
S
I
E
V
L
G
Y
E
L
E
V
L
N
Q
A
-
E
T
P
P
--
F
P
L
-
D
E
------------------------
Y
S
D
V
G
E
E
-----
T
R
L
R
Y
R
F
I
D
L
R
R
P
E
M
A
A
K
L
K
L
R
A
R
I
T
S
S
I
R
R
Y
L
D
D
-
N
G
F
L
D
V
E
T
P
I
L
G
R
P
T
P
E
G
A
R
D
Y
L
V
P
S
R
T
Y
P
G
H
F
F
A
L
P
Q
S
P
Q
L
F
K
Q
L
L
M
V
A
G
F
D
R
Y
Y
Q
I
A
K
C
F
R
D
E
D
L
R
A
D
R
Q
-
P
E
F
T
Q
I
D
I
E
T
S
F
L
-
D
E
S
D
I
I
G
I
T
E
K
M
V
R
Q
L
F
K
-
E
V
-
L
D
----------------
V
E
F
D
E
F
P
H
M
P
F
E
E
A
M
R
R
Y
G
S
D
K
P
D
L
R
I
P
L
E
L
V
D
V
A
D
Q
L
K
E
V
E
F
K
V
F
S
G
P
A
N
D
P
K
-
G
R
V
A
A
L
R
V
P
G
A
-
A
S
M
P
R
S
Q
I
D
D
Y
T
K
F
V
G
-
I
Y
G
A
K
G
L
A
Y
I
K
V
N
E
RAKGV
E
G
-----
L
Q
S
P
I
V
K
F
I
P
E
A
N
L
N
V
I
L
D
R
V
G
A
V
D
G
D
I
V
F
F
G
A
D
K
A
K
I
V
C
D
A
L
G
A
L
R
I
K
V
G
H
D
L
K
-----
L
L
T
R
E
W
A
P
-
M
W
V
V
D
F
P
M
F
---
E
--
E
N
--
D
------------
D
G
-
S
L
S
A
L
H
H
P
F
T
-
S
P
K
----
C
T
P
A
------------
E
----
L
E
A
--
N
PGAALSR
A
Y
D
M
V
L
N
G
T
E
L
G
G
G
S
I
R
I
H
D
K
S
M
Q
Q
A
V
F
R
V
L
G
I
D
E
A
E
Q
E
E
K
F
G
F
L
L
D
A
L
K
Y
G
A
P
P
H
G
G
L
A
F
G
L
D
R
L
V
M
L
M
T
G
A
S
S
I
R
E
V
I
A
F
P
K
T
Q
S
A
G
D
V
M
T
Q
A
P
G
S
V
D
G
K
A
L
R
E
L
H
I
R
L
R
E
--
22
PsiBlast_CBE
92.14
48%
-96
- C5 -
1EQR
1
SYD_ECOLI
C:
[1-585]
M
R
T
E
Y
C
G
Q
L
R
L
S
H
V
G
Q
Q
V
T
L
C
G
W
V
N
R
R
R
D
L
G
S
L
I
F
I
D
M
R
D
R
E
G
I
V
Q
V
F
F
--
D
P
D
R
A
----
D
A
L
K
L
A
S
-
E
L
R
N
E
F
C
I
Q
V
T
G
T
V
R
A
R
D
E
K
N
I
N
R
D
M
A
T
G
E
I
E
V
L
A
S
S
L
T
I
I
N
R
A
-
D
V
L
P
--
L
D
--
S
N
------------------------
H
V
-
N
T
E
E
-----
A
R
L
K
Y
R
Y
L
D
L
R
R
P
E
M
A
Q
R
L
K
T
R
A
K
I
T
S
L
V
R
R
F
M
D
D
-
H
G
F
L
D
I
E
T
P
M
L
T
K
A
T
P
E
G
A
R
D
Y
L
V
P
S
R
V
H
K
G
K
F
Y
A
L
P
Q
S
P
Q
L
F
K
Q
L
L
M
M
S
G
F
D
R
Y
Y
Q
I
V
K
C
F
R
D
E
D
L
R
A
D
R
Q
-
P
E
F
T
Q
I
D
V
E
T
S
F
M
-
T
A
P
Q
V
R
E
V
M
E
A
L
V
R
H
L
W
L
-
E
V
-
K
G
----------------
V
D
L
G
D
F
P
V
M
T
F
A
E
A
E
R
R
Y
G
S
D
K
P
D
L
R
N
P
M
E
L
T
D
V
A
D
L
L
K
S
V
E
F
A
V
F
A
G
P
A
N
D
P
K
-
G
R
V
A
A
L
R
V
P
G
G
-
A
S
L
T
R
K
Q
I
D
E
Y
G
N
F
V
K
-
I
Y
G
A
K
G
L
A
Y
I
K
V
N
E
RAKGL
E
G
-----
I
N
S
P
V
A
K
F
L
N
A
E
I
I
E
D
I
L
D
R
T
A
A
Q
D
G
D
M
I
F
F
G
A
D
N
K
K
I
V
A
D
A
M
G
A
L
R
L
K
V
G
K
D
L
G
-----
L
T
D
E
S
K
W
A
P
L
W
V
I
D
F
P
M
F
---
E
--
D
D
G-
E
------------
G
G
-
L
T
A
M
-
H
H
P
F
T
-
S
P
K
----
D
M
T
A
A
E
----
L
KAAP
E
N
----
A
V
A
--
N
-------
A
Y
D
M
V
I
N
G
Y
E
V
G
G
G
S
V
R
I
H
N
G
D
M
Q
Q
T
V
F
G
I
L
G
I
N
E
E
E
Q
R
E
K
F
G
F
L
L
D
A
L
K
Y
G
T
P
P
H
A
G
L
A
F
G
L
D
R
L
T
M
L
L
T
G
T
D
N
I
R
D
V
I
A
F
P
K
T
T
A
A
A
C
L
M
T
E
A
P
S
F
A
N
P
T
A
L
A
E
L
S
I
Q
V
V
K
K
A
52
HHSearch
91.77
50%
-98
* C5 *
1L0W
-
SYD_THETH
A:
[2-579]
R
R
T
H
Y
A
G
S
L
R
E
T
H
V
G
E
E
V
V
L
E
G
W
V
N
R
R
R
D
L
G
G
L
I
F
L
D
L
R
D
R
E
G
L
V
Q
L
V
A
--
H
P
A
-
S
----
P
A
Y
A
T
A
E
-
R
V
R
P
E
W
V
V
R
A
K
G
L
V
R
L
R
P
E
P
--
N
P
R
L
A
T
G
R
V
E
V
E
L
S
A
L
E
V
L
A
E
A
-
K
T
P
P
--
F
P
V
-
D
A
GWRG
E
E
E
-----------------
K
E
-
A
S
E
E
-----
L
R
L
K
Y
R
Y
L
D
L
R
R
R
R
M
Q
E
N
L
R
L
R
H
R
V
I
K
A
I
W
D
F
L
D
R
-
E
G
F
V
Q
V
E
T
P
F
L
T
K
S
T
P
E
G
A
R
D
F
L
V
P
Y
R
H
E
P
G
L
F
Y
A
L
P
Q
S
P
Q
L
F
K
Q
M
L
M
V
A
G
L
D
R
Y
F
Q
I
A
R
C
F
R
D
E
D
L
R
A
D
R
Q
-
P
D
F
T
Q
L
D
L
E
M
S
F
V
-
E
V
E
D
V
L
E
L
N
E
R
L
M
A
H
V
F
R
-
E
A
L
G
V
----------------
E
L
P
L
P
F
P
R
L
S
Y
E
E
A
M
E
R
Y
G
S
D
K
P
D
L
R
F
G
L
E
L
K
E
V
G
P
L
F
R
Q
S
G
F
R
V
F
Q
E
A
------
E
S
V
K
A
L
A
L
P
K
---
A
L
S
R
K
E
V
A
E
L
E
E
V
A
K
-
R
H
K
A
Q
G
L
A
W
A
R
V
E
E
-----
G
G
-----
F
S
G
G
V
A
K
F
L
E
P
-
V
R
E
A
L
L
Q
A
T
E
A
R
P
G
D
T
L
L
F
V
A
G
P
R
K
V
A
A
T
A
L
G
A
V
R
L
R
A
A
D
L
L
G
-----
L
K
-
R
E
G
F
R
F
L
W
V
V
D
F
P
L
L
---
E
--
W
D
EE
E
------------
E
A
-
W
T
Y
M
-
H
H
P
F
T
-
S
P
H
----
P
E
D
L
P
L
LEKD
P
----
G
R
----
V
R
A
--
L
-------
A
Y
D
L
V
L
N
G
V
E
V
G
G
G
S
I
R
I
H
D
P
R
L
Q
A
R
V
F
R
L
L
G
I
G
E
E
E
Q
R
E
K
F
G
F
F
L
E
A
L
E
Y
G
A
P
P
H
G
G
I
A
W
G
L
D
R
L
L
A
L
M
T
G
S
P
S
I
R
E
V
I
A
F
P
K
N
K
E
G
K
D
P
L
T
G
A
P
S
P
V
P
E
E
Q
L
R
E
L
G
L
M
V
V
R
P
-
25
PsiBlast_CBE
90.02
48%
-94
- C5 -
1G51
3
SYD_THETH
B:
[3-580]
-
R
T
H
Y
A
G
S
L
R
E
T
H
V
G
E
E
V
V
L
E
G
W
V
N
R
R
R
D
L
G
G
L
I
F
L
D
L
R
D
R
E
G
L
V
Q
L
V
A
--
H
P
A
-
S
----
P
A
Y
A
T
A
E
-
R
V
R
P
E
W
V
V
R
A
K
G
L
V
R
L
R
P
E
--
P
N
P
R
L
A
T
G
R
V
E
V
E
L
S
A
L
E
V
L
A
E
A
-
K
T
P
P
FP
V
D
A
-
G
W
------------------------
R
G
-
E
E
E
K
EASEE
L
R
L
K
Y
R
Y
L
D
L
R
R
R
R
M
Q
E
N
L
R
L
R
H
R
V
I
K
A
I
W
D
F
L
D
R
-
E
G
F
V
Q
V
E
T
P
F
L
T
K
S
T
P
E
G
A
R
D
F
L
V
P
Y
R
H
E
P
G
L
F
Y
A
L
P
Q
S
P
Q
L
F
K
Q
M
L
M
V
A
G
L
D
R
Y
F
Q
I
A
R
C
F
R
D
E
D
L
R
A
D
R
Q
-
P
D
F
T
Q
L
D
L
E
M
S
F
V
-
E
V
E
D
V
L
E
L
N
E
R
L
M
A
H
V
F
R
E
A
L
-
G
V
----------------
E
L
P
L
P
F
P
R
L
S
Y
E
E
A
M
E
R
Y
G
S
D
K
P
D
L
R
F
G
L
E
L
K
E
V
G
P
L
F
R
Q
S
G
F
R
V
F
Q
E
A
------
E
S
V
K
A
L
A
L
P
K
A
---
L
S
R
K
E
V
A
E
L
E
E
V
A
K
-
R
H
K
A
Q
G
L
A
W
A
R
V
E
E
-----
G
G
-----
F
S
G
G
V
A
K
F
L
-
E
P
V
R
E
A
L
L
Q
A
T
E
A
R
P
G
D
T
L
L
F
V
A
G
P
R
K
V
A
A
T
A
L
G
A
V
R
L
R
A
A
D
L
L
G
-----
L
-
K
R
E
G
F
R
F
L
W
V
V
D
F
P
L
L
---
E
WD
E
E
--
E
------------
E
A
-
W
T
Y
M
-
H
H
P
F
T
-
S
P
H
----
P
E
D
L
P
L
----
L
----
E
K
DPGR
V
R
A
--
L
-------
A
Y
D
L
V
L
N
G
V
E
V
G
G
G
S
I
R
I
H
D
P
R
L
Q
A
R
V
F
R
L
L
G
I
G
E
E
E
Q
R
E
K
F
G
F
F
L
E
A
L
E
Y
G
A
P
P
H
G
G
I
A
W
G
L
D
R
L
L
A
L
M
T
G
S
P
S
I
R
E
V
I
A
F
P
K
N
K
E
G
K
D
P
L
T
G
A
P
S
P
V
P
E
E
Q
L
R
E
L
G
L
M
V
V
R
P
-
9
PsiBlast_PDB
89.91
48%
-94
- C5 -
1G51
2
SYD_THETH
A:
[3-580]
-
R
T
H
Y
A
G
S
L
R
E
T
H
V
G
E
E
V
V
L
E
G
W
V
N
R
R
R
D
L
G
G
L
I
F
L
D
L
R
D
R
E
G
L
V
Q
L
V
A
--
H
P
A
-
S
----
P
A
Y
A
T
A
E
-
R
V
R
P
E
W
V
V
R
A
K
G
L
V
R
L
R
P
E
--
P
N
P
R
L
A
T
G
R
V
E
V
E
L
S
A
L
E
V
L
A
E
A
-
K
T
P
P
FP
V
D
A
-
G
W
------------------------
R
G
-
E
E
E
K
EAS
E
E
L
R
L
K
Y
R
Y
L
D
L
R
R
R
R
M
Q
E
N
L
R
L
R
H
R
V
I
K
A
I
W
D
F
L
D
R
-
E
G
F
V
Q
V
E
T
P
F
L
T
K
S
T
P
E
G
A
R
D
F
L
V
P
Y
R
H
E
P
G
L
F
Y
A
L
P
Q
S
P
Q
L
F
K
Q
M
L
M
V
A
G
L
D
R
Y
F
Q
I
A
R
C
F
R
D
E
D
L
R
A
D
R
Q
-
P
D
F
T
Q
L
D
L
E
M
S
F
V
-
E
V
E
D
V
L
E
L
N
E
R
L
M
A
H
V
F
R
E
A
L
-
G
V
----------------
E
L
P
L
P
F
P
R
L
S
Y
E
E
A
M
E
R
Y
G
S
D
K
P
D
L
R
F
G
L
E
L
K
E
V
G
P
L
F
R
Q
S
G
F
R
V
F
Q
E
A
------
E
S
V
K
A
L
A
L
P
K
A
---
L
S
R
K
E
V
A
E
L
E
E
V
A
K
-
R
H
K
A
Q
G
L
A
W
A
R
V
E
E
-----
G
G
-----
F
S
G
G
V
A
K
F
L
-
E
P
V
R
E
A
L
L
Q
A
T
E
A
R
P
G
D
T
L
L
F
V
A
G
P
R
K
V
A
A
T
A
L
G
A
V
R
L
R
A
A
D
L
L
G
-----
L
-
K
R
E
G
F
R
F
L
W
V
V
D
F
P
L
L
---
E
W
D
E
E
--
E
------------
E
A
-
W
T
Y
M
-
H
H
P
F
T
-
S
P
H
----
P
E
D
L
P
L
----
L
----
E
K
DPGR
V
R
A
--
L
-------
A
Y
D
L
V
L
N
G
V
E
V
G
G
G
S
I
R
I
H
D
P
R
L
Q
A
R
V
F
R
L
L
G
I
G
E
E
E
Q
R
E
K
F
G
F
F
L
E
A
L
E
Y
G
A
P
P
H
G
G
I
A
W
G
L
D
R
L
L
A
L
M
T
G
S
P
S
I
R
E
V
I
A
F
P
K
N
K
E
G
K
D
P
L
T
G
A
P
S
P
V
P
E
E
Q
L
R
E
L
G
L
M
V
V
R
P
-
6
PsiBlast_PDB
89.91
45%
-87
- C5 -
4O2D
3
SYDND_MYCS2
A:
[24-603]
L
R
T
H
A
A
G
S
L
R
P
A
D
A
G
Q
T
V
T
L
A
G
W
V
A
R
R
R
D
H
G
G
V
I
F
I
D
L
R
D
A
S
G
V
S
Q
V
V
F
--
R
-
E
-
G
----
D
V
L
A
A
A
H
-
R
L
R
A
E
F
C
V
A
V
T
G
V
V
E
V
R
P
E
G
N
E
N
P
E
I
P
T
G
Q
I
E
V
N
A
T
E
L
T
V
L
G
E
S
-
A
P
L
P
--
F
Q
L
--
D
------------------------
E
Q
-
A
G
E
E
-----
A
R
L
K
Y
R
Y
L
D
L
R
R
E
G
P
G
N
A
L
R
L
R
S
K
V
N
A
A
A
R
S
V
L
A
E
-
H
D
F
V
E
I
E
T
P
T
L
T
R
S
T
P
E
G
A
R
D
F
L
V
P
A
R
L
Q
P
G
S
F
Y
A
L
P
Q
S
P
Q
L
F
K
Q
L
L
M
V
A
G
M
E
R
Y
Y
Q
I
A
R
C
Y
R
D
E
D
F
--
D
R
Q
-
P
E
F
T
Q
L
D
M
E
M
S
F
V
-
E
A
D
D
V
I
A
I
S
E
Q
V
L
K
A
V
W
A
-
T
I
-
G
Y
----------------
D
L
P
L
P
L
P
R
I
S
Y
E
E
A
M
R
R
F
G
S
D
K
P
D
L
R
F
G
I
E
L
V
E
C
T
E
Y
F
K
D
T
T
F
R
V
F
----
Q
A
P
Y
---
V
G
A
V
V
M
P
G
G
-
A
S
Q
P
R
R
T
L
D
G
W
Q
E
F
A
K
-
Q
R
G
H
K
G
L
A
Y
V
L
V
G
E
-----
D
G
T
----
L
G
G
P
V
A
K
N
L
S
D
A
E
R
D
G
L
V
A
H
V
G
A
N
P
G
D
C
I
F
F
A
A
G
P
A
K
G
A
R
A
L
L
G
A
T
R
I
E
I
A
K
R
L
D
-----
L
I
D
P
N
A
W
A
F
T
W
V
V
D
F
P
M
F
---
E
--
A
A
--
D
E
A
T
A
A
GDVAVGS
G
A
-
W
T
A
M
-
H
H
A
F
T
-
A
P
K
PD--
S
V
D
T
F
D
----
S
----
D
P
----
G
N
A
LS
D
-------
A
Y
D
I
V
C
N
G
N
E
I
G
G
G
S
I
R
I
H
R
R
D
I
Q
E
R
V
F
A
M
M
G
I
D
H
D
E
A
Q
E
K
F
G
F
L
L
D
A
F
S
Y
G
A
P
P
H
G
G
I
A
F
G
W
D
R
I
T
A
L
L
A
G
V
D
S
I
R
E
V
I
A
F
P
K
S
G
G
G
V
D
P
L
T
D
A
P
A
P
I
T
P
Q
Q
R
K
E
S
G
I
D
-----
10
PsiBlast_PDB
89.87
48%
-97
- C5 -
1L0W
-
SYD_THETH
A:
[3-580]
-
R
T
H
Y
A
G
S
L
R
E
T
H
V
G
E
E
V
V
L
E
G
W
V
N
R
R
R
D
L
G
G
L
I
F
L
D
L
R
D
R
E
G
L
V
Q
L
V
A
--
H
P
A
-
S
----
P
A
Y
A
T
A
E
-
R
V
R
P
E
W
V
V
R
A
K
G
L
V
R
L
R
P
E
--
P
N
P
R
L
A
T
G
R
V
E
V
E
L
S
A
L
E
V
L
A
E
A
-
K
T
P
P
FP
V
D
A
-
G
W
------------------------
R
G
-
E
E
E
K
E
A
S
E
E
L
R
L
K
Y
R
Y
L
D
L
R
R
R
R
M
Q
E
N
L
R
L
R
H
R
V
I
K
A
I
W
D
F
L
D
R
-
E
G
F
V
Q
V
E
T
P
F
L
T
K
S
T
P
E
G
A
R
D
F
L
V
P
Y
R
H
E
P
G
L
F
Y
A
L
P
Q
S
P
Q
L
F
K
Q
M
L
M
V
A
G
L
D
R
Y
F
Q
I
A
R
C
F
R
D
E
D
L
R
A
D
R
Q
-
P
D
F
T
Q
L
D
L
E
M
S
F
V
-
E
V
E
D
V
L
E
L
N
E
R
L
M
A
H
V
F
R
E
A
L
-
G
V
----------------
E
L
P
L
P
F
P
R
L
S
Y
E
E
A
M
E
R
Y
G
S
D
K
P
D
L
R
F
G
L
E
L
K
E
V
G
P
L
F
R
Q
S
G
F
R
V
F
Q
E
A
------
E
S
V
K
A
L
A
L
P
K
A
---
L
S
R
K
E
V
A
E
L
E
E
V
A
K
-
R
H
K
A
Q
G
L
A
W
A
R
V
E
E
-----
G
G
-----
F
S
G
G
V
A
K
F
L
-
E
P
V
R
E
A
L
L
Q
A
T
E
A
R
P
G
D
T
L
L
F
V
A
G
P
R
K
V
A
A
T
A
L
G
A
V
R
L
R
A
A
D
L
L
G
-----
L
-
K
R
E
G
F
R
F
L
W
V
V
D
F
P
L
L
---
E
WD
E
E
--
E
------------
E
A
-
W
T
Y
M
-
H
H
P
F
T
-
S
P
H
----
P
E
D
L
P
L
----
L
----
E
K
DPGR
V
R
A
--
L
-------
A
Y
D
L
V
L
N
G
V
E
V
G
G
G
S
I
R
I
H
D
P
R
L
Q
A
R
V
F
R
L
L
G
I
G
E
E
E
Q
R
E
K
F
G
F
F
L
E
A
L
E
Y
G
A
P
P
H
G
G
I
A
W
G
L
D
R
L
L
A
L
M
T
G
S
P
S
I
R
E
V
I
A
F
P
K
N
K
E
G
K
D
P
L
T
G
A
P
S
P
V
P
E
E
Q
L
R
E
L
G
L
M
V
V
R
P
-
7
PsiBlast_PDB
89.20
45%
-86
- C5 -
4RMF
2
SYDND_MYCS2
A:
[2-580]
L
R
T
H
A
A
G
S
L
R
P
A
D
A
G
Q
T
V
T
L
A
G
W
V
A
R
R
R
D
H
G
G
V
I
F
I
D
L
R
D
A
S
G
V
S
Q
V
V
F
--
R
-
E
-
G
----
D
V
L
A
A
A
H
-
R
L
R
A
E
F
C
V
A
V
T
G
V
V
E
V
R
P
E
G
N
E
N
P
E
I
P
T
G
Q
I
E
V
N
A
T
E
L
T
V
L
G
E
S
-
A
P
L
P
--
F
Q
L
--
D
------------------------
E
Q
-
A
G
E
E
-----
A
R
L
K
Y
R
Y
L
D
L
R
R
E
G
P
G
N
A
L
R
L
R
S
K
V
N
A
A
A
R
S
V
L
A
E
-
H
D
F
V
E
I
E
T
P
T
L
T
R
S
T
P
E
G
A
R
D
F
L
V
P
A
R
L
Q
P
G
S
F
Y
A
L
P
Q
S
P
Q
L
F
K
Q
L
L
M
V
A
G
M
E
R
Y
Y
Q
I
A
R
C
Y
R
D
E
D
F
R
A
D
R
Q
-
P
E
F
T
Q
L
D
M
E
M
S
F
V
-
E
A
D
D
V
I
A
I
S
E
Q
V
L
K
A
V
W
A
-
T
I
-
G
Y
----------------
D
L
P
L
P
L
P
R
I
S
Y
E
E
A
M
R
R
F
G
S
D
K
P
D
L
R
F
G
I
E
L
V
E
C
T
E
Y
F
K
D
T
T
F
R
V
F
----
Q
A
P
Y
---
V
G
A
V
V
M
P
G
G
-
A
S
Q
P
R
R
T
L
D
G
W
Q
E
F
A
K
-
Q
R
G
H
K
G
L
A
Y
V
L
V
G
E
-----
D
G
T
----
L
G
G
P
V
A
K
N
L
S
D
A
E
R
D
G
L
V
A
H
V
G
A
N
P
G
D
C
I
F
F
A
A
G
P
A
K
G
A
R
A
L
L
G
A
T
R
I
E
I
A
K
R
L
D
-----
L
I
D
P
N
A
W
A
F
T
W
V
V
D
F
P
M
F
---
E
--
A
A
--
D
EATAAGDVAVGS
G
A
-
W
T
A
M
-
H
H
A
F
T
-
A
P
K
PD--
S
V
D
T
F
D
----
S
----
D
P
----
G
N
A
LS
D
-------
A
Y
D
I
V
C
N
G
N
E
I
G
G
G
S
I
R
I
H
R
R
D
I
Q
E
R
V
F
A
M
M
G
I
D
H
D
E
A
Q
E
K
F
G
F
L
L
D
A
F
S
Y
G
A
P
P
H
G
G
I
A
F
G
W
D
R
I
T
A
L
L
A
G
V
D
S
I
R
E
V
I
A
F
P
K
S
G
G
G
V
D
P
L
T
D
A
P
A
P
I
T
P
Q
Q
R
K
E
S
G
-------
8
PsiBlast_PDB
88.73
48%
-95
- C5 -
1EFW
-
SYD_THETH
A:
[3-580]
-
R
T
H
Y
A
G
S
L
R
E
T
H
V
G
E
E
V
V
L
E
G
W
V
N
R
R
R
D
L
G
G
L
I
F
L
D
L
R
D
R
E
G
L
V
Q
L
V
A
--
H
P
A
-
S
----
P
A
Y
A
T
A
E
-
R
V
R
P
E
W
V
V
R
A
K
G
L
V
R
L
R
P
E
--
P
N
P
R
L
A
T
G
R
V
E
V
E
L
S
A
L
E
V
L
A
E
A
-
K
T
P
P
FP
V
D
A
-
G
W
------------------------
R
G
-
E
E
E
K
E
A
S
E
E
L
R
L
K
Y
R
Y
L
D
L
R
R
R
R
M
Q
E
N
L
R
L
R
H
R
V
I
K
A
I
W
D
F
L
D
R
-
E
G
F
V
Q
V
E
T
P
F
L
T
K
S
T
P
E
G
A
R
D
F
L
V
P
Y
R
H
E
P
G
L
F
Y
A
L
P
Q
S
P
Q
L
F
K
Q
M
L
M
V
A
G
L
D
R
Y
F
Q
I
A
R
C
F
R
D
E
D
L
R
A
D
R
Q
-
P
D
F
T
Q
L
D
L
E
M
S
F
V
-
E
V
E
D
V
L
E
L
N
E
R
L
M
A
H
V
F
R
E
A
L
-
G
V
----------------
E
L
P
L
P
F
P
R
L
S
Y
E
E
A
M
E
R
Y
G
S
D
K
P
D
L
R
F
G
L
E
L
K
E
V
G
P
L
F
R
Q
S
G
F
R
V
F
Q
E
A
------
E
S
V
K
A
L
A
L
P
K
A
---
L
S
R
K
E
V
A
E
L
E
E
V
A
K
-
R
H
K
A
Q
G
L
A
W
A
R
V
E
E
-----
G
G
-----
F
S
G
G
V
A
K
F
L
-
E
P
V
R
E
A
L
L
Q
A
T
E
A
R
P
G
D
T
L
L
F
V
A
G
P
R
K
V
A
A
T
A
L
G
A
V
R
L
R
A
A
D
L
L
G
-----
L
-
K
R
E
G
F
R
F
L
W
V
V
D
F
P
L
L
---
E
W
D
E
E
--
E
------------
E
A
-
W
T
Y
M
-
H
H
P
F
T
-
S
P
H
----
P
E
D
L
P
L
----
L
----
E
K
DPGR
V
R
A
--
L
-------
A
Y
D
L
V
L
N
G
V
E
V
G
G
G
S
I
R
I
H
D
P
R
L
Q
A
R
V
F
R
L
L
G
I
G
E
E
E
Q
R
E
K
F
G
F
F
L
E
A
L
E
Y
G
A
P
P
H
G
G
I
A
W
G
L
D
R
L
L
A
L
M
T
G
S
P
S
I
R
E
V
I
A
F
P
K
N
K
E
G
K
D
P
L
T
G
A
P
S
P
V
P
E
E
Q
L
R
E
L
G
L
M
V
V
R
P
-
24
PsiBlast_CBE
84.94
45%
-80
- C5 -
4O2D
3
SYDND_MYCS2
B:
[24-603]
L
R
T
H
A
A
G
S
L
R
P
A
D
A
G
Q
T
V
T
L
A
G
W
V
A
R
R
R
D
H
G
G
V
I
F
I
D
L
R
D
A
S
G
V
S
Q
V
V
F
--
R
-
E
-
G
----
D
V
L
A
A
A
H
-
R
L
R
A
E
F
C
V
A
V
T
G
V
V
E
V
R
P
E
G
N
E
N
P
E
I
P
T
G
Q
I
E
V
N
A
T
E
L
T
V
L
G
E
S
-
A
P
L
P
--
F
Q
L
--
D
------------------------
E
Q
-
A
G
E
E
-----
A
R
L
K
Y
R
Y
L
D
L
R
R
E
G
P
G
N
A
L
R
L
R
S
K
V
N
A
A
A
R
S
V
L
A
E
-
H
D
F
V
E
I
E
T
P
T
L
T
R
S
T
P
E
G
A
R
D
F
L
V
P
A
R
L
Q
P
G
S
F
Y
A
L
P
Q
S
P
Q
L
F
K
Q
L
L
M
V
A
G
M
E
R
Y
Y
Q
I
A
R
C
Y
R
D
E
D
F
--
D
R
Q
-
P
E
F
T
Q
L
D
M
E
M
S
F
V
-
E
A
D
D
V
I
A
I
S
E
Q
V
L
K
A
V
W
A
-
T
I
-
G
Y
----------------
D
L
P
L
P
L
P
R
I
S
Y
E
E
A
M
R
R
F
G
S
D
K
P
D
L
R
F
G
I
E
L
V
E
C
T
E
Y
F
--------------
P
Y
---
V
G
A
V
V
M
P
-------------
W
Q
E
F
A
K
-
Q
R
G
----------------------------------------------------
F
F
A
A
G
P
A
K
G
A
R
A
L
L
G
A
T
R
I
E
I
A
K
R
L
D
-----
L
I
D
P
N
A
W
A
F
T
W
V
V
D
F
P
M
F
---
E
--
A
A
--
D
E
A
T
A
A
GDVAVGS
G
A
-
W
T
A
M
-
H
H
A
F
T
-
A
P
K
PD--
S
V
D
T
F
D
----
S
----
D
P
----
G
N
A
LS
D
-------
A
Y
D
I
V
C
N
G
N
E
I
G
G
G
S
I
R
I
H
R
R
D
I
Q
E
R
V
F
A
M
M
G
I
D
H
D
E
A
Q
E
K
F
G
F
L
L
D
A
F
S
Y
G
A
P
P
H
G
G
I
A
F
G
W
D
R
I
T
A
L
L
A
G
V
D
S
I
R
E
V
I
A
F
P
K
S
G
G
G
V
D
P
L
T
D
A
P
A
P
I
T
P
Q
Q
R
K
E
S
G
I
D
-----
11
PsiBlast_PDB
79.90
39%
-83
- C5 -
4AH6
-
SYDM_HUMAN
A:
[49-630]
V
R
T
N
T
C
G
E
L
R
S
S
H
L
G
Q
E
V
T
L
C
G
W
I
Q
Y
R
R
Q
N
---
T
F
L
V
L
R
D
F
D
G
L
V
Q
V
I
I
PQ
D
E
S
-
A
----
A
S
V
K
K
I
L
C
E
A
P
V
E
S
V
V
Q
V
S
G
T
V
I
S
R
P
A
G
Q
E
N
P
K
M
P
T
G
E
I
E
I
K
V
K
T
A
E
L
L
N
A
C
-
K
K
L
P
--
F
E
I
-
K
N
F-----------------------
V
K
-
K
T
E
A
-----
L
R
L
Q
Y
R
Y
L
D
L
R
S
F
Q
M
Q
Y
N
L
R
L
R
S
Q
M
V
M
K
M
R
E
Y
L
C
N
L
H
G
F
V
D
I
E
T
P
T
L
F
K
R
T
P
G
G
A
K
E
F
L
V
P
S
R
-
E
P
G
K
F
Y
S
L
P
Q
S
P
Q
Q
F
K
Q
L
L
M
V
G
G
L
D
R
Y
F
Q
V
A
R
C
Y
R
D
E
G
S
R
P
D
R
Q
-
P
E
F
T
Q
I
D
I
E
M
S
F
V
-
D
Q
T
G
I
Q
S
L
I
E
G
L
L
Q
Y
S
W
P
-
N
D
-
K
D
----------------
P
V
V
V
P
F
P
T
M
T
F
A
E
V
L
A
T
Y
G
T
D
K
P
D
T
R
F
G
M
K
I
I
D
I
S
D
V
F
R
N
T
E
I
G
F
L
Q
D
A
L
S
K
P
H
G
T
-
V
K
A
I
C
I
P
E
G
A
K
Y
L
K
R
K
D
I
E
S
I
R
N
F
A
A
D
H
F
N
Q
E
I
L
P
V
F
L
N
A
N
-----
R
N
-----
W
N
S
P
V
A
N
F
I
M
E
S
Q
R
L
E
L
I
R
L
M
E
T
Q
E
E
D
V
V
L
L
T
A
G
E
H
N
K
A
C
S
L
L
G
K
L
R
L
E
C
A
D
L
L
E
T
RGVV
L
R
D
P
T
L
F
S
F
L
W
V
V
D
F
P
L
F
L
P
K
E
--
E
N
--
P
------------
R
E
-
L
E
S
A
-
H
H
P
F
T
-
A
P
H
PSDI
H
L
L
Y
T
E
----
P
----
K
K
----
A
R
S
--
Q
-------
H
Y
D
L
V
L
N
G
N
E
I
G
G
G
S
I
R
I
H
N
A
E
L
Q
R
Y
I
L
A
T
L
---
L
K
E
D
V
K
M
L
S
H
L
L
Q
A
L
D
Y
G
A
P
P
H
G
G
I
A
L
G
L
D
R
L
I
C
L
V
T
G
S
P
S
I
R
D
V
I
A
F
P
K
S
F
R
G
H
D
L
M
S
N
T
P
D
S
V
P
P
E
E
L
K
P
Y
H
-------
58
HHSearch
66.21
27%
-86
- C5 -
3I7F
-
?
A:
[48-542]
----
E
I
E
E
L
V
P
A
M
A
E
K
T
V
T
I
R
A
R
V
Q
A
V
R
G
K
G
N
M
V
F
L
F
L
R
K
G
I
Y
T
C
Q
A
L
V
--
M
K
S
-
E
TIS
K
E
F
V
Q
F
C
Q
-
K
I
S
A
E
S
I
C
D
I
T
G
I
V
K
A
V
E
K
P
I
--
E
K
A
T
Q
Q
D
V
E
I
H
V
T
S
I
A
V
V
S
L
A
E
Y
P
L
P
--
M
Q
I
E
D
L
T
FP
S
S
V
F
K
K
Q
E
E
D
IAKVKASA
Q
K
Y
V
K
-
V
S
Q
D
-----
T
R
L
D
N
R
M
L
D
L
R
T
V
T
N
I
A
I
F
R
I
Q
S
A
C
C
G
L
F
R
E
F
L
T
S
-
Q
K
F
V
E
I
H
T
P
K
L
I
---------------------
A
Y
L
A
Q
S
P
Q
L
Y
K
Q
M
A
I
M
G
D
F
R
K
V
F
E
V
G
P
V
F
R
A
E
N
S
N
T
R
R
H
L
T
E
F
E
G
L
D
I
E
M
E
I
V
E
N
Y
H
E
C
I
D
V
M
E
K
L
F
T
F
I
F
D
-
E
I
P
K
R
F
P
D
E
L
K
V
I
R
K
Q
Y
P
F
E
D
L
I
Y
R
P
F
L
R
L
T
Y
K
E
A
I
E
M
L
R
A
S
G
E
------
T
I
G
D
Y
----------------------------------------------------------------------------------
D
D
F
T
T
--------------------------
P
Q
E
V
K
L
G
E
L
I
---
K
A
K
Y
-----------
N
T
D
F
Y
I
L
D
K
F
P
A
------------------------------
A
-
I
R
P
F
Y
T
M
P
D
----
I
D
D
-------------
P
----
N
Y
S
--
N
-------
S
Y
D
V
F
V
R
G
Q
E
I
T
S
G
A
Q
R
I
H
D
P
E
F
L
M
K
R
C
I
E
K
G
V
D
P
----
A
T
L
K
D
Y
I
E
S
F
R
F
G
S
W
P
H
A
G
C
G
I
G
L
E
R
I
T
M
L
Y
L
G
I
P
N
I
R
K
V
T
L
F
P
R
D
P
I
R
L
N
P
------------------------
56
HHSearch
65.17
32%
-78
- C5 -
3NEM
1
SYD_THEKO
A:
[2-436]
Y
R
T
H
Y
S
S
E
I
T
E
E
L
N
G
Q
K
V
K
V
A
G
W
V
W
E
V
K
D
L
G
G
I
K
F
L
W
I
R
D
R
D
G
I
V
Q
I
T
A
--
P
K
K
-
K
VD
P
-
E
L
F
K
L
I
P
-
K
L
R
S
E
D
V
V
A
V
E
G
V
V
N
F
T
P
K
-------
A
K
L
G
F
E
I
L
P
E
K
I
V
V
L
N
R
A
E
T
P
L
P
--
L
D
P
T
G
K
------------------------
V
K
-
A
E
L
D
-----
T
R
L
D
N
R
F
M
D
L
R
R
P
E
V
M
A
I
F
K
I
R
S
S
V
F
K
A
V
R
D
F
F
H
E
-
N
G
F
I
E
I
H
T
P
K
I
I
A
T
A
T
E
G
G
T
E
L
F
P
M
K
Y
--
F
E
E
D
A
F
L
A
Q
S
P
Q
L
Y
K
Q
I
M
M
A
S
G
L
D
R
V
Y
E
I
A
P
I
F
R
A
E
E
H
N
T
T
R
H
L
N
E
A
W
S
I
D
S
E
M
A
F
I
E
D
E
E
E
V
M
S
F
L
E
R
L
V
A
H
A
I
N
-
Y
V
R
E
H
N
A
K
E
L
D
I
L
N
F
E
L
E
---
E
P
K
L
P
F
P
R
V
S
Y
D
K
A
L
E
I
L
G
D
L
G
K
E
I
P
W
G
----------------------------------------------------------------------------------------
E
D
I
D
T
E
--------------------------
G
E
R
L
L
G
K
Y
---
M
M
E
N
-----------
E
N
A
P
L
Y
F
L
Y
Q
Y
P
S
------------------------------
E
-
A
K
P
F
Y
-
I
M
K
----
Y
D
N
------------
K
P
----
E
I
C
--
R
-------
A
F
D
L
E
Y
R
G
V
E
I
S
S
G
G
Q
R
E
H
R
H
D
I
L
V
E
Q
I
K
E
K
G
L
N
P
----
E
S
F
E
F
Y
L
K
A
F
R
Y
G
M
P
P
H
G
G
F
G
L
G
A
E
R
L
I
K
Q
M
L
D
L
P
N
I
R
E
V
I
L
F
P
R
D
R
R
R
L
T
P
------------------------