@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : jhp_0727: (2015-12-17 )
MQEYHIHNLDCPDCAAKLERDLNKLDYVKKAQINFSTSKLFLDTSDFEKVKAFIKQNEPHLSLSFKEAAEKPLSFTPLIATIAVFLGAILILHLEPSPFIEKAVFVVLALVYLISGKDVILGAFRGLRKGQFFDENALMLIATIAAFCVGAYEESVSIMVFYSAGEFLQILAIARSKKSLKALVDVAPNLAYLKKGDTLVSVAPEDLRINDIVVVKVGEKVPVDGVVIKGESLLDERALSGESMPVNVSERSKVLGGSLNLKAVLEIQVEKLYKDSSIAKVVDLVQQATNEKSETEKFITKFSRYYTPSVLFIALMIAVLPPLFSMGSFDEWIYRGLVALMVSCPCALVISVPLGYFGGVGAASRKGILMKGVHVLEVLTQTKSIAFDKTGTLTKGVFKVVDIVPQNGHSKEEVLHYASCSQLLSTHPIALSIQKACEEMLKDDKHQHDIKNYEELSGMGVKAQCHTDLIIAGNEKMLDQFHIAHSPSPENGTIVHVAFNQTYIGYIVISDEIKDDAIECLRDLKAQGIENFCILSGDRKSATESIARTLGCEYHASLLPEEKTSVFKTFKERYKAPAIFVGDGINDAPTLASADVGIGMGKGSELSKQSADIVITNDSLSSLVKVLAIAKKTKSIIWQNILFALGIKAVFIVLGLMGVASLWEAVFGDVGVTLLALANSMRTMRA
Atome Classification :
(25 SA)
.........10........20........30........40....----....50.....-----...60........70.-----......-.80--.-.......90.--..-.....100.......110...-.....120.......130.......140.......150-----------.-------------........160.......170.......180.......190-....-.--..200.......210.......220.......230-.---.-......240.....-------------..250---------..----------......260.......270.......280.......290.......300.......310....-------....320.-..-....330.......----340......--.350.--------......360.....----..370.......380.......390.......400--......---..-.---------------------------------410----------------.----------------........420.----------------.....-----------------------.430--------------------------------------..-..-....440.--.--.--..------------..450.......---460...----.----------------.----------.---------.470---------------...--------------....---------------------.480------.--.------------------.---....---------.---------.490-......------------------------.-----------------------500-----------------------........510.......520.......530.......540.......550-------------------------------.------------------------------.------------------------------------------------------..-....------------------------560.......570.......580.......590.......600........610.......620.......630.......640...----....650...---------...-------.660.....--------..670.......680....----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MQEYHIHNLD
C
P
D
C
A
A
K
L
E
R
D
L
N
K
L
D
Y
V
K
K
A
Q
I
NFST
S
K
L
F
LDTS----
D
F
E
K
V
K
A
F
I
KQ-----NEP
H
L
S
L
S
F
K
E
AAEKP-----LS
F
T
P
L
-
I
A
T
--
I
-
A
V
F
L
G
A
I
L
I
L
--HL-EPS
P
F
I
E
K
A
V
F
V
V
L
A
L
-
V
Y
L
I-SG
K
D
V
I
L
G
A
F
R
GLRKGQFFDEN
A
L
M
L
I
A
T
I
A
A
F
C
V
G
-------------A-------------YEE
S
V
S
I
M
V
F
YSA
G
E
F
L
Q
I
L
A
I
AR
S
K
K
S
L
K
A
L
V
D
VAP
N
L
A
Y
-LKKG-
D
--
T
L
V
S
VAPED
L
R
I
N
D
I
V
V
V
KVGEKVPVD
G
V
V
IK
G
-
E
-
S
---
L
-
L
D
E
RALSGESMPV
N
-------------
V
S
E
R
----------
S
K
----------VLGGSL
N
L
K
A
V
L
E
I
Q
V
E
K
L
YKD
S
S
I
A
K
V
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D
L
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ATNE
K
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YYT
P
S
V
-
L
F
I
A
L
-------
M
I
A
VL
P
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L
-
F
S-MG
S
F
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W
I
Y
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G
L
V
A
----
L
M
VSC
P
C
A
L
--
V
I
SVP--------
L
G
YFGGVGAASRK
G
----
I
L
M
K
G
V
H
V
L
E
V
L
T
QTK
S
I
AFDKTG
T
L
T
K
G
V
F
K
V
----
V
DIVPQ---NG-H---------------------------------
S
------------------
K
----------------
E
E
V
L
H
Y
A
S
C
S
Q
L
----------------
L
STHP-----------------------
I
A
L
---------------------------------------
S
I
-
Q
K
-
A
C
E
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M
L
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D--D--
K
--
H
Q
------------
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SGM---G
V
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A
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C
----
H
----------------
T
----------
D
---------
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I
I
----------------AG
N
--------------
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L
---------------------
D
Q
--------
F
--H------------------I---AHSP---------S---------PEN
G
-
T
I
V
H
V
A
------------------------F-----------------------NQ------------------------
T
Y
I
G
Y
I
V
I
SDEI
K
D
D
A
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C
L
R
D
L
K
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QGIE
N
F
C
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LSGDR
K
S
A
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R
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LG--------------------------------
C
------------------------------
E
------------------------------------------------------
Y
H
-
A
S
LL------------------------
P
E
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K
T
S
V
F
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F
K
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YKA
P
A
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F
VGDGINDAPTLASADVGIGMG-KGSELSKQSA
D
I
V
I
TND
S
L
S
S
L
V
K
V
L
A
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A
K
K
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W
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N
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A
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----
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---------
L
M
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-------
V
A
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L
W
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A
V
F
--------
G
D
V
G
V
T
L
L
A
L
A
N
S
M
R
TMRA----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
3
PsiBlast_PDB
89.30
31%
-91
- C6 -
3J09
-
COPA_ARCFU
A:
[21-701]
----
R
V
T
G
M
T
C
A
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V
K
S
I
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---
A
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V
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H
-----
L
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M
K
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-
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--
V
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A
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L
L
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-------------
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STAGVLPREYSF
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-----------------------
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--------------
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L
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---------------------
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--------
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--
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------------------
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---
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---------
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V
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------------------------
R
-----------------------
N
G
------------------------
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L
N
--------------------------------
L
------------------------------
D
------------------------------------------------------
L
V
I
A
E
V
L
------------------------
P
H
Q
K
S
E
E
V
K
--
K
L
Q
A
K
E
V
V
A
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N
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--------
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Y
N
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I
L
---------
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P
A
-------
A
A
G
L
L
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--------
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V
V
F
R
P
E
F
A
G
L
A
M
A
M
S
S
V
S
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
111
HHSearch
88.86
30%
-87
- C2 -
3J09
-
COPA_ARCFU
A:
[17-727]
E
R
T
V
R
V
T
G
M
T
C
A
M
C
V
K
S
I
E
T
A
V
G
S
L
E
G
V
E
E
V
R
V
N
L
A
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T
A
F
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R
F
D
EKRI
D
F
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I
K
R
V
I
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D
-----
L
G
Y
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V
V
D
E
Q
A
A
V
S
A
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V
-----
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H
L
S
R
M
K
R
K
L
--
Y
V
A
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F
A
G
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L
L
L
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L
-
A
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F
I
S
L
P
Y
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D
F
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Q
L
L
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A
L
P
-
A
I
F
Y
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-
R
R
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T
L
N
M
D
V
M
Y
S
M
G
V
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A
A
F
L
A
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V
L
STAGVLPREYS
F
-------------
Y
E
T
S
V
L
L
L
A
F
L
L
L
G
R
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L
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----
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---
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-----------------------------------
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A
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A
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E
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P
-----------------------
I
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---------------------------------------
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A
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-------
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---
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V
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N
--------------
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L
M
---------------------
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-------
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-
A
V
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N
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--------------
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A
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K
L
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T
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V
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V
A
------------------------
R
-----------------------
N
G
------------------------
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N
--------------------------------
L
------------------------------
D
L
-----------------------------------------------------
V
I
-
A
E
V
L
------------------------
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H
Q
K
S
E
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V
K
K
L
Q
A
--
K
E
V
V
A
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V
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D
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I
N
D
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P
A
L
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D
L
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-
S
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A
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Q
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M
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N
I
F
W
A
L
----
I
Y
N
V
I
L
I
P
A
A
---------
A
G
L
L
Y
P
IFGV
V
F
R
P
E
F
A
G
L
--------
A
M
A
M
S
S
V
S
V
V
A
N
S
L
L
L
R
N
Y
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
2
PsiBlast_PDB
88.84
33%
-95
- C2 -
4UMW
2
?
A:
[124-730]
---------------------------------------------------------------------------------RLKEN
L
P
L
I
T
L
-
I
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M
--
M
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A
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S
W
G
L
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--
H
-----
P
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Q
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A
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I
A
T
T
L
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V
G
L
Y
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P
---
I
A
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Q
A
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R
L
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F
A
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M
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V
A
A
I
G
A
L
F
I
G
-------------
A
-------------
T
A
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A
A
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L
L
L
F
L
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G
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W
A
A
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R
----
V
S
A
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A
L
K
P
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A
T
-
R
L
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N
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G
--
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V
A
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A
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L
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---
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A
L
T
G
E
S
I
P
V
E
-------------
R
A
T
G
----------
D
K
----------
V
P
A
G
A
T
S
V
D
R
L
V
T
L
E
V
L
S
E
P
G
A
S
A
I
D
R
I
L
K
L
I
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E
A
E
E
R
R
A
P
I
E
R
F
I
D
R
F
S
R
I
Y
T
P
A
I
-
M
A
V
A
L
-------
L
V
T
L
V
P
P
L
-
L
F
-
A
A
S
W
Q
E
W
I
Y
K
G
L
T
L
----
L
L
I
G
C
P
C
A
L
--
V
I
S
T
P
--------
A
A
I
T
S
G
L
A
A
A
A
R
R
G
----
A
L
I
K
G
G
A
A
L
E
Q
L
G
R
V
T
Q
V
A
F
D
K
T
G
T
L
T
V
G
K
P
R
V
----
T
A
I
H
P
A
---
T
G
-
I
---------------------------------
S
------------------
E
----------------
S
E
L
L
T
L
A
A
A
V
E
Q
----------------
G
A
T
H
P
-----------------------
L
A
Q
---------------------------------------
A
I
-
V
R
----
E
A
Q
V
A
--
E
--
L
--
A
I
------------
P
T
A
E
S
Q
R
A
L
V
G
S
---
G
I
E
A
Q
V
----
N
----------------
G
----------
E
R
V
-------
L
I
C
----------------
A
A
G
--------------
K
H
P
A
---------------------
D
A
--------
F
--
A
G
-----------------
L
---
I
N
E
L
---------
E
---------
S
A
G
Q
-
T
V
V
L
V
V
------------------------
R
-----------------------
N
D
------------------------
D
V
L
G
I
I
A
L
Q
D
T
L
R
A
D
A
A
T
A
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L
N
A
L
G
V
K
G
V
-
I
L
T
G
D
N
P
R
A
A
A
A
I
A
G
E
L
G
--------------------------------
L
------------------------------
E
------------------------------------------------------
F
K
-
A
G
L
L
------------------------
P
E
D
K
V
K
A
V
T
K
L
N
Q
H
--
A
P
L
A
M
V
G
D
G
I
N
D
A
P
A
M
K
A
A
A
I
G
I
A
M
G
-
S
G
T
D
V
A
L
E
T
A
D
A
A
L
T
H
N
H
L
R
G
L
V
Q
M
I
E
L
A
R
A
T
H
A
N
I
R
Q
N
I
T
I
A
L
----
G
L
K
G
I
F
L
V
T
T
---------
L
L
G
-------
M
T
G
L
W
L
A
V
L
--------
A
D
T
G
A
T
V
L
V
T
A
N
A
L
R
L
L
R
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
101
Fugue
86.76
33%
-77
- C2 -
4UMW
2
?
A:
[124-730]
----------------
R
L
K
E
N
L
P
L
I
T
L
I
V
M
M
A
I
S
W
G
L
E
Q
F
N
H
P
F
G
----
Q
L
A
F
I
A
T
T
L
V
G
-----
L
Y
P
I
A
R
Q
A
L
R
L
I
K
-------------------------------------------------------------------------
S
G
S
Y
F
A
I
E
T
L
M
S
V
A
A
I
G
A
L
F
I
G
-------------
A
-------------
T
A
E
A
A
M
V
L
L
L
F
L
I
G
E
R
L
E
G
W
A
----
A
S
R
V
S
A
L
M
A
L
K
P
E
T
A
T
-
R
L
R
N
-
G
--
E
R
E
E
V
A
I
N
S
L
R
P
G
D
V
I
E
V
A
A
G
G
R
L
P
A
D
G
K
L
L
S
P
-
F
-
A
---
S
-
F
D
E
S
A
L
T
G
E
S
I
P
V
E
-------------
R
A
T
G
----------
D
K
----------
V
P
A
G
A
T
S
V
D
R
L
V
T
L
E
V
L
S
E
P
G
A
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A
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I
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L
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A
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F
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R
F
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I
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A
I
-
M
A
V
A
L
-------
L
V
T
L
V
P
P
L
-
L
F
-
A
A
S
W
Q
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W
I
Y
K
G
L
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L
----
L
L
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C
P
C
A
L
--
V
I
S
T
P
--------
A
A
I
T
S
G
L
A
A
A
A
R
R
G
----
A
L
I
K
G
G
A
A
L
E
Q
L
G
R
V
T
Q
V
A
F
D
K
T
G
T
L
T
V
G
K
P
R
V
----
T
A
I
H
P
A
---
T
G
-
I
---------------------------------
S
------------------
E
----------------
S
E
L
L
T
L
A
A
A
V
E
Q
----------------
G
A
T
H
P
-----------------------
L
A
Q
---------------------------------------
A
I
-
V
R
-
E
A
Q
V
---
A
--
E
--
L
--
A
I
------------
P
T
A
E
S
Q
R
A
L
V
G
S
---
G
I
E
A
Q
V
----
N
G
E
--------------
R
----------
V
---------
L
I
C
----------------
A
A
G
--------------
K
H
P
A
---------------------
D
A
--------
F
--
A
------------------
G
---
L
I
N
E
---------
L
---------
E
S
A
G
-
Q
T
V
V
L
V
------------------------
V
R
----------------------
N
D
------------------------
D
V
L
G
I
I
A
L
Q
D
T
L
R
A
D
A
A
T
A
I
S
E
L
N
A
L
G
V
-
K
G
V
I
L
T
G
D
N
P
R
A
A
A
A
I
A
G
E
L
G
--------------------------------
L
------------------------------
E
------------------------------------------------------
F
K
-
A
G
L
L
------------------------
P
E
D
K
V
K
A
V
T
K
L
N
Q
H
--
A
P
L
A
M
V
G
D
G
I
N
D
A
P
A
M
K
A
A
A
I
G
I
A
M
G
-
S
G
T
D
V
A
L
E
T
A
D
A
A
L
T
H
N
H
L
R
G
L
V
Q
M
I
E
L
A
R
A
T
H
A
N
I
R
Q
N
I
T
I
A
L
----
G
L
K
G
I
F
L
V
T
T
---------
L
L
G
-------
M
T
G
L
W
L
A
V
L
--------
A
D
T
G
A
T
V
L
V
T
A
N
A
L
R
L
L
R
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
1
PsiBlast_PDB
85.90
33%
-90
- C3 -
4UMV
2
?
A:
[126-730]
---------------------------------------------------------------------------------KEN--
L
P
L
I
T
L
-
I
V
M
--
M
-
A
I
S
W
G
L
E
Q
F
N
--
H
-----
P
F
G
Q
L
A
-
F
I
A
T
T
L
-
V
G
L
Y
-
P
---
I
A
R
Q
A
L
R
L
I
K
S
G
S
Y
F
A
I
E
T
L
M
S
V
A
A
I
G
A
L
F
I
G
-------------
A
-------------
T
A
E
A
A
M
V
L
L
L
F
L
I
G
E
R
L
E
G
W
A
A
S
R
A
R
Q
G
V
S
A
L
M
A
L
K
P
E
T
A
T
-
R
L
R
N
-
G
--
E
R
E
E
V
A
I
N
S
L
R
P
G
D
V
I
E
V
A
A
G
G
R
L
P
A
D
G
K
L
L
S
P
-
F
-
A
---
S
-
F
D
E
S
A
L
T
G
E
S
I
P
V
E
-------------
R
A
T
G
----------
D
K
----------
V
P
A
G
A
T
S
V
D
R
L
V
T
L
E
V
L
S
E
P
G
A
S
A
I
D
R
I
L
K
L
I
E
E
A
E
E
R
R
A
P
I
E
R
F
I
D
R
F
S
R
I
Y
T
P
A
I
-
M
A
V
A
L
-------
L
V
T
L
V
P
P
L
-
L
F
-
A
A
S
W
Q
E
W
I
Y
K
G
L
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----
L
L
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C
P
C
A
L
--
V
I
S
T
P
--------
A
A
I
T
S
G
L
A
A
A
A
R
R
G
----
A
L
I
K
G
G
A
A
L
E
Q
L
G
R
V
T
Q
V
A
F
D
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G
T
L
T
V
G
K
P
R
V
----
T
A
I
H
P
A
---
T
G
-
I
---------------------------------
S
------------------
E
----------------
S
E
L
L
T
L
A
A
A
V
E
Q
----------------
G
A
T
H
P
-----------------------
L
A
Q
---------------------------------------
A
I
-
V
R
----
E
A
Q
V
A
--
E
--
L
--
A
I
------------
P
T
A
E
S
Q
R
A
L
V
G
S
---
G
I
E
A
Q
V
----
N
----------------
G
----------
E
R
V
-------
L
I
C
----------------
A
A
G
--------------
K
H
P
A
---------------------
D
A
--------
F
--
A
G
-----------------
L
---
I
N
E
L
---------
E
---------
S
A
G
Q
-
T
V
V
L
V
V
------------------------
R
-----------------------
N
D
------------------------
D
V
L
G
I
I
A
L
Q
D
T
L
R
A
D
A
A
T
A
I
S
E
L
N
A
L
G
V
K
G
V
-
I
L
T
G
D
N
P
R
A
A
A
A
I
A
G
E
L
G
--------------------------------
L
------------------------------
E
------------------------------------------------------
F
K
-
A
G
L
L
------------------------
P
E
D
K
V
K
A
V
T
K
L
N
Q
H
--
A
P
L
A
M
V
G
D
G
I
N
D
A
P
A
M
K
A
A
A
I
G
I
A
M
G
-
S
G
T
D
V
A
L
E
T
A
D
A
A
L
T
H
N
H
L
R
G
L
V
Q
M
I
E
L
A
R
A
T
H
A
N
I
R
Q
N
I
T
I
A
L
----
G
L
K
G
I
F
L
V
T
T
---------
L
L
G
-------
M
T
G
L
W
L
A
V
L
--------
A
D
T
G
A
T
V
L
V
T
A
N
A
L
R
L
L
R
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
102
Fugue
82.41
24%
-86
- C2 -
3RFU
3
?
A:
[74-736]
------
V
S
P
E
Y
L
D
M
R
R
R
F
W
I
A
L
M
L
T
I
P
V
V
I
L
E
M
G
------------------------
G
H
-----
G
L
K
H
F
I
S
G
N
G
S
S
W
I
Q
L
-----
L
L
A
T
P
V
-
V
L
W
GG
W
-
P
F
F
K
R
G
W
Q
S
L
--
K
--
T
G
Q
L
N
M
F
T
L
I
A
M
G
I
G
V
-
A
W
I
Y
-
S
M
V
A
V
L
---
W
P
G
V
F
P
H
A
F
R
S
Q
E
G
-----
V
V
A
V
Y
------------------------------
F
E
A
A
A
V
I
T
T
L
V
L
L
G
Q
V
L
E
L
K
A
R
E
Q
T
G
S
A
I
R
A
L
L
K
L
V
P
E
S
A
H
-
R
I
K
E
D
G
--
S
E
E
E
V
S
L
D
N
V
A
V
G
D
L
L
R
V
R
P
G
E
K
I
P
V
D
G
E
V
Q
E
G
-
R
-
S
---
F
-
V
D
E
S
M
V
T
G
E
P
I
P
V
A
-------------
K
E
A
S
----------
A
K
----------
V
I
G
A
T
I
N
Q
T
G
S
F
V
M
K
A
L
H
V
G
S
D
T
M
L
A
R
I
V
Q
M
V
S
D
A
Q
R
S
R
A
P
I
Q
R
L
A
D
T
V
S
G
W
F
V
P
A
V
-
I
L
V
A
V
-------
L
S
F
I
V
W
A
L
-
L
G
P
Q
P
A
L
S
Y
G
L
I
A
A
V
S
V
----
L
I
I
A
C
P
C
A
L
--
G
L
A
T
P
--------
M
S
I
M
V
G
V
G
K
G
A
Q
S
G
----
V
L
I
K
N
A
E
A
L
E
R
M
E
K
V
N
T
L
V
V
D
K
T
G
T
L
T
E
G
H
P
K
L
----
T
R
I
V
T
----
D
D
-
F
---------------------------------
V
------------------
E
----------------
D
N
A
L
A
L
A
A
A
L
E
H
----------------
Q
S
E
H
P
-----------------------
L
A
N
---------------------------------------
A
I
-
V
H
-
A
A
K
E
---
K
--
G
--
L
--
S
L
------------
G
S
V
E
A
F
E
A
P
T
G
K
---
G
V
V
G
Q
V
----
D
----------------
G
----------
H
---------
H
V
A
----------------
I
G
N
--------------
A
R
L
M
---------------------
Q
E
H
G
G
D
N
A
P
L
F
--
E
------------------
K
---
A
D
E
L
---------
R
---------
G
K
G
A
-
S
V
M
F
M
A
------------------------
V
-----------------------
D
G
------------------------
K
T
V
A
L
L
V
V
E
D
P
I
K
S
S
T
P
E
T
I
L
E
L
Q
Q
S
G
I
E
-
I
V
M
L
T
G
D
S
K
R
T
A
E
A
V
A
G
T
L
G
--------------------------------
I
------------------------------
K
K
-----------------------------------------------------
V
V
-
A
E
I
M
------------------------
P
E
D
K
S
R
I
V
S
E
L
K
D
K
-
G
L
I
V
A
M
A
G
D
G
V
N
D
A
P
A
L
A
K
A
D
I
G
I
A
M
G
-
T
G
T
D
V
A
I
E
S
A
G
V
T
L
L
H
G
D
L
R
G
I
A
K
A
R
R
L
S
E
S
T
M
S
N
I
R
Q
N
L
F
F
A
F
----
I
Y
N
V
L
G
V
P
L
A
A
GVLYPLTG
L
L
L
-------
S
P
M
I
A
A
A
A
M
--------
A
L
S
S
V
S
V
I
I
N
A
L
R
L
K
R
V
T
L
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
4
PsiBlast_PDB
82.20
33%
-87
- C6 -
3J08
-
COPA_ARCFU
A:
[104-701]
--------------------------------------------------------------------------------------------------
V
-
A
A
F
A
G
V
L
L
L
F
L
A
H
F
-
I
S
L
P
Y
-
E
D
F
V
Q
L
L
I
A
L
-
P
A
I
F
Y
S
G
S
S
I
F
K
A
A
F
S
A
L
R
R
-
R
T
L
N
M
D
V
M
Y
S
M
G
V
G
A
A
F
L
A
S
-------------
V
L
S
T
A
GVLPREYSF
Y
E
T
S
V
L
L
L
A
F
L
L
L
G
R
T
L
E
A
R
A
K
S
R
T
G
E
A
I
K
K
L
V
G
L
Q
A
K
T
A
V
-
V
I
R
D
-
G
--
K
E
I
A
V
P
V
E
E
V
A
V
G
D
I
V
I
V
R
P
G
E
K
I
P
V
D
G
V
V
V
E
G
-
E
-
S
---
Y
-
V
D
E
S
M
I
S
G
E
P
V
P
V
L
-------------
K
S
K
G
----------
D
E
----------
V
F
G
A
T
I
N
N
T
G
V
L
K
I
R
A
T
R
V
G
G
E
T
L
L
A
Q
I
V
K
L
V
E
D
A
M
G
S
K
P
P
I
Q
R
L
A
D
K
V
V
A
Y
F
I
P
T
V
-
L
L
V
A
I
S
A
F
IYWY
F
I
A
H
A
P
L
L
-
F
A
-
F
T
T
L
-------
I
A
V
----
L
V
V
A
C
P
C
A
F
--
G
L
A
T
P
--------
T
A
L
T
V
G
M
G
K
G
A
E
L
G
----
I
L
I
K
N
A
D
A
L
E
V
A
E
K
V
T
A
V
I
F
D
K
T
G
T
L
T
K
G
K
P
E
V
----
T
D
L
V
P
L
---
N
G
-
D
---------------------------------
E
------------------
R
-----------------
E
L
L
R
L
A
A
I
A
E
R
----------------
R
S
E
H
P
-----------------------
I
A
E
---------------------------------------
A
I
-
V
K
-
K
A
---
L
E
H
--
G
--
I
--
E
L
------------
G
E
P
E
K
V
E
V
I
A
G
E
---
G
V
V
A
----------------------------------
D
---------
G
I
L
----------------
V
G
N
--------------
K
R
L
M
---------------------
E
D
--------
F
--
G
------------------
V
---
A
V
S
N
E
V
E
L
A
L
E
K
L
E
---------
R
E
A
K
-
T
A
V
I
V
A
------------------------
R
-----------------------
N
G
------------------------
R
V
E
G
I
I
A
V
S
D
T
L
K
E
S
A
K
P
A
V
Q
E
L
K
R
M
G
I
K
-
V
G
M
I
T
G
D
N
W
R
S
A
E
A
I
S
R
E
L
N
--------------------------------
L
------------------------------
D
------------------------------------------------------
L
V
I
A
E
V
L
------------------------
P
H
Q
K
S
E
E
V
K
--
K
L
Q
A
K
E
V
V
A
F
V
G
D
G
I
N
D
A
P
A
L
A
Q
A
D
L
G
I
A
V
G
-
S
G
S
D
V
A
V
E
S
G
D
I
V
L
I
R
D
D
L
R
D
V
V
A
A
I
Q
L
S
R
K
T
M
S
K
I
K
Q
N
I
F
W
A
L
--------
I
Y
N
V
I
L
---------
I
P
A
-------
A
A
G
L
L
Y
P
I
F
--------
G
V
V
F
R
P
E
F
A
G
L
A
M
A
M
S
S
V
S
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
112
HHSearch
81.39
32%
-81
- C6 -
3J08
-
COPA_ARCFU
A:
[124-727]
------------------------------------------------------------------------------------------------------------------------
E
D
F
V
Q
L
L
I
A
L
P
-
A
I
F
Y
-
S
G
S
S
I
F
K
A
A
F
S
A
L
-
R
R
R
T
L
N
M
D
V
M
Y
S
M
G
V
G
A
A
F
L
A
S
V
L
S
T
A
GVLPREYS
F
-------------
Y
E
T
S
V
L
L
L
A
F
L
L
L
G
R
T
L
E
A
R
A
K
S
R
T
G
E
A
I
K
K
L
V
G
L
Q
A
K
T
A
V
-
V
I
R
D
-
G
--
K
E
I
A
V
P
V
E
E
V
A
V
G
D
I
V
I
V
R
P
G
E
K
I
P
V
D
G
V
V
V
E
G
-
E
-
S
---
Y
-
V
D
E
S
M
I
S
G
E
P
V
P
V
L
-------------
K
S
K
G
----------
D
E
----------
V
F
G
A
T
I
N
N
T
G
V
L
K
I
R
A
T
R
V
G
G
E
T
L
L
A
Q
I
V
K
L
V
E
D
A
M
G
S
K
P
P
I
Q
R
L
A
D
K
V
V
A
Y
F
I
P
T
V
-
L
L
V
A
I
-------
S
A
F
I
Y
W
Y
F
-
I
A
-
H
A
P
L
L
F
A
F
T
T
L
I
A
V
----
L
V
V
A
C
P
C
A
F
--
G
L
A
T
P
--------
T
A
L
T
V
G
M
G
K
G
A
E
L
G
----
I
L
I
K
N
A
D
A
L
E
V
A
E
K
V
T
A
V
I
F
D
K
T
G
T
L
T
K
G
K
P
E
V
----
T
D
L
V
P
L
---
N
G
-----------------------------------
D
------------------
E
----------------
R
E
L
L
R
L
A
A
I
A
E
R
----------------
R
S
E
H
P
-----------------------
I
A
E
---------------------------------------
A
I
-
V
K
-
K
A
L
E
H
G
-------
I
--
E
L
------------
G
E
P
E
K
V
E
V
I
A
G
E
---
G
V
V
A
----------------------------------
D
---------
G
I
L
----------------
V
G
N
--------------
K
R
L
M
---------------------
E
D
F
-------
G
V
-
A
V
S
N
E
--------------
V
E
L
A
L
E
K
L
---------
E
---------
R
E
A
K
-
T
A
V
I
V
A
------------------------
R
-----------------------
N
G
------------------------
R
V
E
G
I
I
A
V
S
D
T
L
K
E
S
A
K
P
A
V
Q
E
L
K
R
M
G
I
K
-
V
G
M
I
T
G
D
N
W
R
S
A
E
A
I
S
R
E
L
N
--------------------------------
L
------------------------------
D
L
-----------------------------------------------------
V
I
-
A
E
V
L
------------------------
P
H
Q
K
S
E
E
V
K
K
L
Q
A
--
K
E
V
V
A
F
V
G
D
G
I
N
D
A
P
A
L
A
Q
A
D
L
G
I
A
V
G
-
S
G
S
D
V
A
V
E
S
G
D
I
V
L
I
R
D
D
L
R
D
V
V
A
A
I
Q
L
S
R
K
T
M
S
K
I
K
Q
N
I
F
W
A
L
----
I
Y
N
V
I
L
I
P
A
A
---------
A
G
L
L
Y
P
IFGV
V
F
R
P
E
F
A
G
L
--------
A
M
A
M
S
S
V
S
V
V
A
N
S
L
L
L
R
N
Y
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
6
PsiBlast_PDB
74.49
28%
-79
- C3 -
4BEV
2
?
A:
[188-693]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
E
A
A
A
V
I
T
T
L
V
L
L
G
Q
V
L
E
L
K
A
R
E
Q
T
G
S
A
I
R
A
L
L
K
L
V
P
E
S
A
H
R
I
K
E
D
-
G
--
S
E
E
E
V
S
L
D
N
V
A
V
G
D
L
L
R
V
R
P
G
E
K
I
P
V
D
G
E
V
Q
E
G
-
R
-
S
---
F
-
V
D
E
S
M
V
T
G
E
P
I
P
V
A
-------------
K
E
A
S
----------
A
K
----------
V
I
G
A
T
I
N
Q
T
G
S
F
V
M
K
A
L
H
V
G
S
D
T
M
L
A
R
I
V
Q
M
V
S
D
A
Q
R
S
R
A
P
I
Q
R
L
A
D
T
V
S
G
W
F
V
P
A
V
-
I
L
V
A
V
-------
L
S
F
I
V
W
A
L
----
L
G
P
Q
P
A
L
S
Y
-
G
L
I
A
A
V
S
V
L
I
I
A
C
P
C
A
L
--
G
L
A
T
P
--------
M
S
I
M
V
G
V
G
K
G
A
Q
S
G
----
V
L
I
K
N
A
E
A
L
E
R
M
E
K
V
N
T
L
V
V
D
K
T
G
T
L
T
E
G
H
P
K
L
----
T
R
I
V
T
D
---
D
--
F
---------------------------------
V
------------------
E
----------------
D
N
A
L
A
L
A
A
A
L
E
H
----------------
Q
S
E
H
P
-----------------------
L
A
N
---------------------------------------
A
I
-
V
H
-
A
A
K
E
---
K
--
G
--
L
--
S
L
------------
G
S
V
E
A
F
E
A
P
T
G
K
---
G
V
V
G
Q
V
----
D
----------------
G
----------
H
---------
H
V
A
----------------
I
G
N
--------------
A
R
L
M
---------------------
Q
E
H
G
G
D
N
A
P
L
F
--
E
------------------
K
---
A
D
E
L
---------
R
---------
G
K
G
A
-
S
V
M
F
M
A
------------------------
V
-----------------------
D
G
------------------------
K
T
V
A
L
L
V
V
E
D
P
I
K
S
S
T
P
E
T
I
L
E
L
Q
Q
S
G
I
E
-
I
V
M
L
T
G
D
S
K
R
T
A
E
A
V
A
G
T
L
G
--------------------------------
I
K-----------------------------
K
------------------------------------------------------
V
V
-
A
E
I
M
------------------------
P
E
D
K
S
R
I
V
S
E
L
K
D
K
G
L
I
V
A
M
-
A
G
D
G
V
N
D
A
P
A
L
A
K
A
D
I
G
I
A
M
G
-
T
G
T
D
V
A
I
E
S
A
G
V
T
L
L
H
G
D
L
R
G
I
A
K
A
R
R
L
S
E
S
T
M
S
N
I
R
Q
N
L
F
F
A
F
--------
I
Y
N
V
L
G
---------
V
P
L
-------
A
A
G
V
L
Y
P
L
T
--------
G
L
L
L
S
P
M
I
A
A
A
A
M
A
L
S
S
V
S
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
7
PsiBlast_PDB
73.87
28%
-81
- C3 -
4BYG
3
?
A:
[188-693]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
E
A
A
A
V
I
T
T
L
V
L
L
G
Q
V
L
E
L
K
A
R
E
Q
T
G
S
A
I
R
A
L
L
K
L
V
P
E
S
A
H
R
I
K
E
D
-
G
--
S
E
E
E
V
S
L
D
N
V
A
V
G
D
L
L
R
V
R
P
G
E
K
I
P
V
D
G
E
V
Q
E
G
-
R
-
S
---
F
-
V
D
E
S
M
V
T
G
E
P
I
P
V
A
-------------
K
E
A
S
----------
A
K
----------
V
I
G
A
T
I
N
Q
T
G
S
F
V
M
K
A
L
H
V
G
S
D
T
M
L
A
R
I
V
Q
M
V
S
D
A
Q
R
S
R
A
P
I
Q
R
L
A
D
T
V
S
G
W
F
V
P
A
V
-
I
L
V
A
V
-------
L
S
F
I
V
W
A
L
----
L
G
P
Q
P
A
L
S
Y
-
G
L
I
A
A
V
S
V
L
I
I
A
C
P
C
A
L
--
G
L
A
T
P
--------
M
S
I
M
V
G
V
G
K
G
A
Q
S
G
----
V
L
I
K
N
A
E
A
L
E
R
M
E
K
V
N
T
L
V
V
D
K
T
G
T
L
T
E
G
H
P
K
L
----
T
R
I
V
T
D
---
D
--
F
---------------------------------
V
------------------
E
----------------
D
N
A
L
A
L
A
A
A
L
E
H
----------------
Q
S
E
H
P
-----------------------
L
A
N
---------------------------------------
A
I
-
V
H
-
A
A
K
E
---
K
--
G
--
L
--
S
L
------------
G
S
V
E
A
F
E
A
P
T
G
K
---
G
V
V
G
Q
V
----
D
----------------
G
----------
H
---------
H
V
A
----------------
I
G
N
--------------
A
R
L
M
---------------------
Q
E
H
G
G
D
N
A
P
L
F
--
E
------------------
K
---
A
D
E
L
---------
R
---------
G
K
G
A
-
S
V
M
F
M
A
------------------------
V
-----------------------
D
G
------------------------
K
T
V
A
L
L
V
V
E
D
P
I
K
S
S
T
P
E
T
I
L
E
L
Q
Q
S
G
I
E
-
I
V
M
L
T
G
D
S
K
R
T
A
E
A
V
A
G
T
L
G
--------------------------------
I
K-----------------------------
K
------------------------------------------------------
V
V
-
A
E
I
M
------------------------
P
E
D
K
S
R
I
V
S
E
L
K
D
K
G
L
I
V
A
M
-
A
G
D
G
V
N
D
A
P
A
L
A
K
A
D
I
G
I
A
M
G
-
T
G
T
D
V
A
I
E
S
A
G
V
T
L
L
H
G
D
L
R
G
I
A
K
A
R
R
L
S
E
S
T
M
S
N
I
R
Q
N
L
F
F
A
F
--------
I
Y
N
V
L
G
---------
V
P
L
-------
A
A
G
V
L
Y
P
L
T
--------
G
L
L
L
S
P
M
I
A
A
A
A
M
A
L
S
S
V
S
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
5
PsiBlast_PDB
73.85
28%
-80
- C3 -
3RFU
3
?
A:
[188-693]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
E
A
A
A
V
I
T
T
L
V
L
L
G
Q
V
L
E
L
K
A
R
E
Q
T
G
S
A
I
R
A
L
L
K
L
V
P
E
S
A
H
R
I
K
E
D
-
G
--
S
E
E
E
V
S
L
D
N
V
A
V
G
D
L
L
R
V
R
P
G
E
K
I
P
V
D
G
E
V
Q
E
G
-
R
-
S
---
F
-
V
D
E
S
M
V
T
G
E
P
I
P
V
A
-------------
K
E
A
S
----------
A
K
----------
V
I
G
A
T
I
N
Q
T
G
S
F
V
M
K
A
L
H
V
G
S
D
T
M
L
A
R
I
V
Q
M
V
S
D
A
Q
R
S
R
A
P
I
Q
R
L
A
D
T
V
S
G
W
F
V
P
A
V
-
I
L
V
A
V
-------
L
S
F
I
V
W
A
L
----
L
G
P
Q
P
A
L
S
Y
-
G
L
I
A
A
V
S
V
L
I
I
A
C
P
C
A
L
--
G
L
A
T
P
--------
M
S
I
M
V
G
V
G
K
G
A
Q
S
G
----
V
L
I
K
N
A
E
A
L
E
R
M
E
K
V
N
T
L
V
V
D
K
T
G
T
L
T
E
G
H
P
K
L
----
T
R
I
V
T
D
---
D
--
F
---------------------------------
V
------------------
E
----------------
D
N
A
L
A
L
A
A
A
L
E
H
----------------
Q
S
E
H
P
-----------------------
L
A
N
---------------------------------------
A
I
-
V
H
-
A
A
K
E
---
K
--
G
--
L
--
S
L
------------
G
S
V
E
A
F
E
A
P
T
G
K
---
G
V
V
G
Q
V
----
D
----------------
G
----------
H
---------
H
V
A
----------------
I
G
N
--------------
A
R
L
M
---------------------
Q
E
H
G
G
D
N
A
P
L
F
--
E
------------------
K
---
A
D
E
L
---------
R
---------
G
K
G
A
-
S
V
M
F
M
A
------------------------
V
-----------------------
D
G
------------------------
K
T
V
A
L
L
V
V
E
D
P
I
K
S
S
T
P
E
T
I
L
E
L
Q
Q
S
G
I
E
-
I
V
M
L
T
G
D
S
K
R
T
A
E
A
V
A
G
T
L
G
--------------------------------
I
K-----------------------------
K
------------------------------------------------------
V
V
-
A
E
I
M
------------------------
P
E
D
K
S
R
I
V
S
E
L
K
D
K
G
L
I
V
A
M
-
A
G
D
G
V
N
D
A
P
A
L
A
K
A
D
I
G
I
A
M
G
-
T
G
T
D
V
A
I
E
S
A
G
V
T
L
L
H
G
D
L
R
G
I
A
K
A
R
R
L
S
E
S
T
M
S
N
I
R
Q
N
L
F
F
A
F
--------
I
Y
N
V
L
G
---------
V
P
L
-------
A
A
G
V
L
Y
P
L
T
--------
G
L
L
L
S
P
M
I
A
A
A
A
M
A
L
S
S
V
S
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
19
PsiBlast_PDB
71.68
23%
-72
- C3 -
3B8C
2
PMA2_ARATH
A:
[151-688]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
D
I
V
S
I
K
L
G
D
I
I
P
A
D
A
R
L
L
E
G
-
D
-
P
---
L
K
V
D
Q
S
A
L
T
G
E
S
L
P
V
T
-------------
K
H
P
G
----------
Q
E
----------
V
F
S
G
S
T
C
K
Q
G
E
I
E
A
V
V
I
A
T
G
V
H
T
F
F
G
K
A
A
H
L
V
D
-
S
T
N
Q
V
G
H
F
Q
K
V
L
T
A
I
G
N
F
C
I
C
S
I
A
I
G
M
V
I
-------
E
I
I
V
M
Y
P
I
--
Q
-
R
R
K
Y
R
D
G
I
D
N
L
L
V
L
----
L
I
G
G
I
P
I
A
M
PT
V
L
S
V
T
--------
M
A
I
--
G
S
H
R
L
S
Q
Q
G
----
A
I
T
K
R
M
T
A
I
E
E
M
A
G
M
D
V
L
C
S
D
K
T
G
T
L
T
L
N
K
L
S
V
D
KNL
V
E
V
F
C
K
----
G
-
V
---------------------------------
E
------------------
K
----------------
D
Q
V
L
L
F
A
A
M
A
S
R
----------------
V
E
N
Q
D
-----------------------------------------------------------------
A
I
-
D
A
-
A
M
V
G
M
L
A
D
--
P
--
K
--
E
A
RAGIREVHFL
P
F
N
P
V
D
K
R
T
A
L
T
Y
I
---
D
G
S
G
N
W
----
H
----------------
R
V
S
K
G
A
P
E
Q
I
L
E
---------
L
A
K
----------------
A
S
N
D
L
S
K
K
V
L
S
I
I
D
KYA
E
R
G
L
---------------------
R
S
--------
L
--
A
------------------
V
---
A
R
Q
V
---------
V
---------
P
E
K
--
T
K
E
S
P
G
------------------------
A
-----------------------
P
W
------------------------
E
F
V
G
L
L
P
L
F
D
P
P
R
H
D
S
A
E
T
I
R
R
A
L
N
L
G
V
-
N
V
K
M
I
T
G
D
Q
L
A
I
G
K
E
T
G
R
R
L
G
MGTNMYPSSALLGTHKDANLASIP
V
E
E
L
I
E
K-
A
------------------------------
D
------------------------------------------------------
G
F
-
A
G
V
F
------------------------
P
E
H
K
Y
E
I
V
K
K
L
Q
E
R
-
K
H
I
V
G
M
T
G
D
G
V
N
D
A
P
A
L
K
K
A
D
I
G
I
A
V
A
-
D
A
T
D
A
A
R
G
A
S
D
I
V
L
T
E
P
G
L
S
V
I
I
S
A
V
L
T
S
R
A
I
F
Q
R
M
K
N
Y
T
I
Y
A
V
----
S
I
-
T
I
R
I
V
F
G
---------
F
M
L
-------
I
A
L
I
W
E
F
D
F
--------
S
A
F
M
V
L
I
I
A
I
L
N
D
G
T
I
M
T
I
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
108
Fugue
68.65
18%
-66
- C2 -
3B8E
6
AT1A1_PIG
A:
[1-998]
------------------
A
K
K
E
R
D
M
D
E
L
K
K
E
V
S
M
D
D
H
K
L
S
L
D
E
L
H
----
R
K
Y
G
T
D
L
S
R
G
L
-----
T
P
A
R
A
A
E
I
L
A
R
D
G
P
N
A
-----
L
T
P
P
P
T
-
T
P
E
--
W
-
V
K
F
C
R
Q
L
--------------
F
G
G
F
S
M
L
L
W
I
-
G
A
I
L
-
C
F
L
A
Y
G
I
Q
A
A
T
E
E
E
P
Q
N
D
N
L
Y
L
G
V
V
L
S
A
V
V
I
I
T
G
C
F
-------------
S
-------------
Y
Y
Q
E
------------------
A
K
S
S
K
I
M
E
S
F
K
N
M
V
P
Q
Q
A
L
-
V
I
R
N
-
G
--
E
K
M
S
I
N
A
E
E
V
V
V
G
D
L
V
E
V
K
G
G
D
R
I
P
A
D
L
R
I
I
S
A
-
N
-
G
---
C
K
V
D
N
S
S
L
T
G
E
S
E
P
Q
T
-------------
R
S
P
D
----------
F
T
N
ENPLETRNI
A
F
F
S
T
N
C
V
E
G
T
A
R
G
I
V
V
Y
T
G
D
R
T
V
M
G
R
I
A
T
L
A
S
G
L
E
G
G
Q
T
P
I
A
A
E
I
E
H
F
I
H
I
I
T
G
V
A
-
V
F
L
G
V
-------
S
F
F
I
L
S
L
I
-
L
E
-
Y
-
T
W
L
E
A
V
I
F
L
I
G
I
----
I
V
A
N
V
P
E
G
L
--
L
A
T
V
T
--------
V
C
L
T
L
T
A
K
R
M
A
R
K
N
----
C
L
V
K
N
L
E
A
V
E
T
L
G
S
T
S
T
I
C
S
D
K
T
G
T
L
T
Q
N
R
M
T
V
----
A
H
M
W
S
D
---
N
Q
-
I
---------------------------------
H
------------------
E
A
DTTENQSGVSFDKTS
A
T
W
L
A
L
S
R
I
A
G
L
----------------
C
N
R
A
V
F
Q
A
NQENLPILK
R
A
V
A
GD
A
S
E
S
A
L
L
K
---------------------------------------
C
I
-
E
L
-
C
C
G
S
V
K
E
M
--
R
--
E
--
R
Y
------------
T
K
I
V
E
I
P
F
N
S
T
N
---
K
Y
Q
L
S
I
----
H
----------------
K
----------
N
PNTAEPR
H
L
L
V
M
----------------
K
G
A
--------------
P
E
R
I
L
D
R
CS
S
I
L
I
HGKEQPLDEEL
K
D
A
--------
F
--
Q
------------------
N
---
A
Y
L
E
---------
L
---------
G
G
L
G
E
R
V
L
G
F
C
------------------------
H
-----------------------
L
F
L
P
DEQFPEGF
Q
F
D
T
DDVNFPLDN
L
C
F
V
G
L
I
S
M
I
D
P
P
R
A
A
V
P
D
A
V
G
K
C
R
S
A
G
I
K
V
I
M
V
-
T
G
D
H
P
I
T
A
K
A
I
A
K
G
V
G
--------------------------------
I
ISEGN
E
T
V
E
D
IAARLNIPVSQVNPRDAK
A
C
V
------------------------------------------------------
V
H
-
G
S
D
L
K
D
MT
S
E
Q
L
D
D
I
L
K
YHTEIVFARTS
P
Q
Q
K
L
I
I
V
E
G
C
Q
-
R
Q
G
A
I
V
A
V
T
G
D
G
V
N
D
S
P
A
S
K
K
A
D
I
G
V
A
M
G
I
A
G
S
D
V
S
K
Q
A
A
D
M
I
L
L
D
D
N
F
A
S
I
V
T
G
V
E
E
G
R
L
I
F
D
N
L
K
K
S
I
A
Y
T
L
TS
N
I
P
E
I
T
P
F
L
I
F
I
---------
I
A
N
-------
I
P
L
P
L
G
T
V
T
I
L
C
I
DLGT
D
M
V
P
A
I
S
L
A
Y
E
Q
A
E
S
D
I
M
K
RQPRNPKTDKLVN
E
Q
L
I
S
M
A
YGQ
I
G
M
I
Q
A
L
G
G
F
F
T
Y
F
V
I
L
A
E
N
GFLPIHLL
G
L
R
V
N
WDDRWINDVEDSYG
Q
Q
W
T
Y
EQRKIVEFT
C
H
T
P
F
F
V
T
I
V
V
V
Q
W
A
D
L
V
I
C
KTRRNSVFQQGMKN
K
I
L
I
F
G
L
F
E
E
T
A
L
A
A
F
L
S
Y
CPGMGVA
L
R
M
Y
P
LKPTWWFCAFPY
S
L
L
I
F
V
Y
D
E
V
R
K
L
I
I
R
R
RPGGW
V
E
K
E
T
YY
115
HHSearch
67.88
20%
-66
- C2 -
3B8C
2
PMA2_ARATH
A:
[95-657]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
F
V
G
I
I
C
L
L
V
I
N
S
T
I
S
F
I
E
E
N
N
A
G
N
A
A
A
A
L
M
A
G
L
A
P
K
T
K
-
V
L
R
D
-
G
--
K
W
S
E
Q
E
A
A
I
L
V
P
G
D
I
V
S
I
K
L
G
D
I
I
P
A
D
A
R
L
L
E
G
-
D
P
L
---
K
-
V
D
Q
S
A
L
T
G
E
S
L
P
V
T
-------------
K
H
P
G
----------
Q
E
----------
V
F
S
G
S
T
C
K
Q
G
E
I
E
A
V
V
I
A
T
G
V
H
T
F
F
G
K
A
A
H
L
V
D
S
T
N
-
Q
V
G
H
F
Q
K
V
L
T
A
I
G
N
F
C
I
C
S
I
-
A
I
G
M
V
-------
I
E
I
I
V
M
Y
P
-
I
Q
-
R
R
K
Y
R
D
G
I
D
N
L
L
V
L
----
L
I
G
G
I
P
I
A
M
--
P
T
V
L
S
--------
V
T
M
A
I
G
S
H
R
L
S
Q
Q
G
----
A
I
T
K
R
M
T
A
I
E
E
M
A
G
M
D
V
L
C
S
D
K
T
G
T
L
T
L
N
K
L
S
V
----
D
K
N
L
V
E
VFC
K
G
-
V
---------------------------------
E
------------------
K
----------------
D
Q
V
L
L
F
A
A
M
A
S
R
V---------------
E
N
Q
D
A
-----------------------
I
D
A
---------------------------------------
A
M
-
V
G
-
M
L
A
D
P
K
E
A
RA
G
--
I
--
R
E
------------
V
H
F
L
P
F
N
P
V
D
K
R
---
T
A
L
T
Y
I
DG--
S
----------------
G
N
W
--------
H
---------
R
V
S
----------------
K
G
A
--------------
P
E
Q
I
---------------------
L
E
L-------
A
--
K
ASND
L
S
K
K
----------
V
L
S
I
I
D
K
Y
---------
A
---------
E
R
G
L
-
R
S
L
A
V
A
------------------------
R
Q
VVPEKTKESPG
A
----------
P
W
------------------------
E
F
V
G
L
L
P
L
F
D
P
P
R
H
D
S
A
E
T
I
R
R
A
L
N
L
G
V
N
-
V
K
M
I
T
G
D
Q
L
A
I
G
K
E
T
G
R
R
L
G
--------------------------------
M
------------------------------
G
TNMYPSSALLGTHKDANLASIP
V
E
E
L
I
E
K
A
D
-----------------------
G
F
-
A
G
V
F
------------------------
P
E
H
K
Y
E
I
V
K
K
L
Q
E
R
-
K
H
I
V
G
M
T
G
D
G
V
N
D
A
P
A
L
K
K
A
D
I
G
I
A
V
A
-
D
A
T
D
A
A
R
G
A
S
D
I
V
L
T
E
P
G
L
S
V
I
I
S
A
V
L
T
S
R
A
I
F
Q
R
M
K
N
Y
T
I
Y
A
V
----
S
I
T
I
R
I
V
F
G
F
---------
M
L
I
-------
A
L
I
W
E
F
D
F
S
--------
A
F
M
V
L
I
I
A
I
L
N
D
G
T
I
M
T
I
S
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
114
HHSearch
67.20
19%
-67
- C2 -
2ZXE
5
?
A:
[135-793]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
Y
L
G
V
V
L
S
T
V
V
I
V
T
G
C
F
S
Y
Y
Q
E
A
K
S
S
R
I
M
D
S
F
K
N
M
V
P
Q
Q
A
L
-
V
I
R
D
-
G
--
E
K
S
T
I
N
A
E
F
V
V
A
G
D
L
V
E
V
K
G
G
D
R
I
P
A
D
L
R
I
I
S
A
H
G
-
C
---
K
-
V
D
N
S
S
L
T
G
E
S
E
P
Q
T
-------------
R
S
P
E
FSSENPLETR
N
I
----------
A
F
F
S
T
N
C
V
E
G
T
A
R
G
V
V
V
Y
T
G
D
R
T
V
M
G
R
I
A
T
L
A
S
G
L
E
V
G
R
T
P
I
A
I
E
I
E
H
F
I
H
I
I
T
G
V
A
-
V
F
L
G
V
-------
S
F
F
I
L
S
L
--
I
L
-
G
Y
S
W
L
E
A
V
I
F
L
I
G
I
----
I
V
A
N
V
P
E
G
L
--
L
A
T
V
T
--------
V
C
L
T
L
T
A
K
R
M
A
R
K
N
----
C
L
V
K
N
L
E
A
V
E
T
L
G
S
T
S
T
I
C
S
D
K
T
G
T
L
T
Q
N
R
M
T
V
----
A
H
M
W
F
D
---
N
Q
I
H
---------------------------------
E
A
DTTENQSGAAFDKTS
A
T
W
----------------
S
A
L
S
R
I
A
A
L
C
N
R
A
V
F
Q
A
GQDNVPILKRS
V
A
G
D
A
-----------------------
S
E
S
---------------------------------------
A
L
-
L
K
-
C
I
E
L
C
C
G
S
--
V
Q
G
M
R
D
R
N
------------
P
K
I
V
E
I
P
F
N
S
T
N
K
Y
Q
L
S
I
H
E
N
EKSS
E
----------------
S
R
Y
--------
L
---------
L
V
M
----------------
K
G
A
--------------
P
E
R
I
---------------------
L
D
R
-------
C
--
S
TILLNG
A
E
E
P
LK
E
D
M
K
E
A
F
Q
N
A
Y
L
E
L
---------
G
---------
G
L
G
E
-
R
V
L
G
F
C
H
F
ALPEDKYNEG
Y
P
F
D
ADEPNFPT
T
-----------------------
D
L
------------------------
C
F
V
G
L
M
A
M
I
D
P
P
R
A
A
V
P
D
A
V
G
K
C
R
S
A
G
I
K
-
V
I
M
V
T
G
D
H
P
I
T
A
K
A
I
A
K
G
V
G
--------------------------------
I
------------------------------
I
SEGNET
I
E
D
I
A
A
R
L
NIPIGQVNPRDAK
A
C
V
V
H
G
S
D
L
K
D
LS
T
E
V
L
D
D
I
L
H
Y
H
T
E
I
V
F
-
A
R
T
S
------------------------
P
Q
Q
K
L
I
I
V
E
G
C
Q
R
Q
-
G
A
I
V
A
V
T
G
D
G
V
N
D
S
P
A
L
K
K
A
D
I
G
V
A
M
G
I
S
G
S
D
V
S
K
Q
A
A
D
M
I
L
L
D
D
N
F
A
S
I
V
T
G
V
E
E
G
R
L
I
F
D
N
L
K
K
S
I
A
Y
T
L
----
T
S
N
I
P
E
I
T
P
F
---------
L
V
F
-------
I
I
G
N
V
P
L
P
L
--------
G
T
V
T
I
L
C
I
D
L
G
T
D
M
V
P
A
I
S
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
21
PsiBlast_CBE
66.91
37%
-84
- C3 -
3A1D
2
?
B:
[13-284]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
A
E
L
G
I
L
I
K
N
A
D
A
L
E
V
A
E
K
V
T
A
V
I
F
D
K
T
G
T
L
T
K
G
K
P
E
V
----
T
D
L
V
P
L
---
N
G
-
D
---------------------------------
E
------------------
R
----------------
E
-
L
L
R
L
A
A
I
A
E
R
----------------
R
S
E
H
P
-----------------------
I
A
E
---------------------------------------
A
I
V
K
K
-
A
L
E
H
G
I
----------
E
L
------------
G
E
P
E
K
V
E
V
I
A
G
E
---
G
V
V
A
----------------------------------
D
---------
G
I
L
----------------
V
G
N
--------------
K
R
L
M
---------------------
E
D
--------
F
--
G
------------------
V
---
A
V
S
N
---------
E
V
E
L
A
L
E
K
L
E
R
E
A
K
-
T
A
V
I
V
A
------------------------
R
-----------------------
N
G
------------------------
R
V
E
G
I
I
A
V
S
D
T
L
K
E
S
A
K
P
A
V
Q
E
L
K
R
M
G
I
K
-
V
G
M
I
T
G
D
N
W
R
S
A
E
A
I
S
R
E
L
N
--------------------------------
L
------------------------------
D
------------------------------------------------------
L
V
I
A
E
V
L
------------------------
P
H
Q
K
S
E
E
V
K
K
L
Q
--
A
K
E
V
V
A
F
V
G
D
G
I
N
D
A
P
A
L
A
Q
A
D
L
G
I
A
V
G
-
S
G
S
D
V
A
V
E
S
G
D
I
V
L
I
R
D
D
L
R
D
V
V
A
A
I
Q
L
S
R
K
T
M
S
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
107
Fugue
66.46
17%
-78
- C2 -
1SU4
3
AT2A1_RABIT
A:
[1-994]
M
E
A
A
H
--------------------------------------
S
K
----
S
T
E
E
C
L
A
Y
F
G
V
-----
S
E
T
T
-
G
L
T
P
D
Q
V
K
R
H
L
-----
E
K
Y
---------------
G
H
N
E
L
P
--
A
E
-
E
G
K
S
L
W
E
L
V
I
E
Q
F
E
D
L
-
L
V
R
I
-
L
L
L
A
A
C
I
S
F
V
L
A
W
F
E
E
G
E
E
T
I
--------------
T
-------------
A
-------------
F
V
E
P
F
V
I
L
L
I
L
I
A
N
A
I
V
G
V
W
Q
E
R
N
A
E
N
A
I
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A
L
K
E
Y
E
P
E
M
G
K
-
V
Y
R
A
-
D
RK
S
V
Q
R
I
K
A
R
D
I
V
P
G
D
I
V
E
V
A
V
G
D
K
V
P
A
D
I
R
I
L
S
I
-
K
-
S
T
T
L
R
-
V
D
Q
S
I
L
T
G
E
S
V
S
V
I
K
H
TEPVPDPRAVN
Q
D
K
K
----------
N
M
----------
L
F
S
G
T
N
I
A
A
G
K
A
L
G
I
V
A
T
T
G
V
S
T
E
I
G
K
I
R
D
Q
M
A
A
T
E
Q
D
K
T
P
L
Q
Q
K
L
D
E
F
G
E
Q
L
S
K
V
I
-
S
L
I
C
V
-------
A
V
W
L
I
N
I
G
H
F
N
-
D
P
V
H
G
G
S
W
I
R
G
A
I
Y
----
Y
F
K
I
A
V
A
L
A
--
V
A
A
I
P
EG
L
P
A
V
I
T
T
C
L
A
L
G
T
R
R
M
A
K
K
N
----
A
I
V
R
S
L
P
S
V
E
T
L
G
C
T
S
V
I
C
S
D
K
T
G
T
L
T
T
N
Q
M
S
V
----
C
K
M
F
I
I
---
D
K
-
V
DGD
F
C
S
L
N
E
F
S
I
T
G
S
T
YAP
E
G
E
V
L
K
ND
K
P
I
R
SG
Q
------------------
F
----------------
D
G
L
V
E
L
A
T
I
C
A
L
----------------
C
N
D
S
S
-----------------------
L
D
F
NETKG
V
Y
E
K
V
G
E
A
T
E
T
A
L
T
T
L
V
E
K
M
NVFNTEVRNLSKVE
R
A
-
N
A
-
C
N
S
V
I
R
Q
L
--
M
--
K
--
K
E
------------
F
T
L
E
F
S
R
D
R
K
S
M
---
S
V
Y
C
S
P
----
A
KSSRAAVG
N
K
M
F
V
K
GA
P
----------
E
---------
G
V
I
D
R
CN
Y
V
R
V
GT
T
R
V
P
MT
G
P
V
--------------
K
E
K
I
---------------------
L
S
--------
V
--
I
------------------
K
---
E
W
G
T
---------
G
---------
R
D
T
L
-
R
C
L
A
L
A
------------------------
T
RDTPPKREEMVLDDSSR
F
M
E
Y
E
T
D
L
------------------------
T
F
V
G
V
V
G
M
L
D
P
P
R
K
E
V
M
G
S
I
Q
L
C
R
D
A
G
I
-
R
V
I
M
I
T
G
D
N
K
G
T
A
I
A
I
C
R
R
I
G
IFGENEEVADRAYT
G
R
E
F
D
D
LP
L
A
E
Q
R
E
A
C
R
R
A
------------------------------
C
------------------------------------------------------
C
F
-
A
R
V
E
------------------------
P
S
H
K
S
K
I
V
E
Y
L
Q
S
Y
-
D
E
I
T
A
M
T
G
D
G
V
N
D
A
P
A
L
K
K
A
E
I
G
I
A
M
G
-
S
G
T
A
V
A
K
T
A
S
E
M
V
L
A
D
D
N
F
S
T
I
V
A
A
V
E
E
G
R
A
I
Y
N
N
M
K
Q
F
I
R
Y
L
I
----
S
S
N
V
G
E
V
V
C
I
---------
F
L
T
-------
A
A
L
G
L
P
E
A
L
--------
I
P
V
Q
L
L
W
V
N
L
V
T
D
G
L
P
A
T
A
L
G
F
NPPDLDIMDRPPRSPKEPLIS
G
W
L
F
F
R
Y
M
A
I
G
G
Y
V
G
A
A
T
V
G
A
A
A
W
W
F
MYAEDGPGVTYHQLTHFMQCTEDHPHFEGLDCEIFEAP
E
P
M
T
M
A
L
S
V
L
V
T
I
E
M
C
N
A
L
N
S
LSENQSLMRMPPWVN
I
W
L
L
G
S
I
C
L
S
M
S
L
H
F
L
I
L
YV
D
P
L
P
M
I
F
K
L
K
A
L
D
L
T
Q
W
L
M
V
L
K
I
S
L
P
V
I
G
L
D
E
I
L
K
F
I
A
R
N
YLEG--
23
PsiBlast_CBE
66.15
36%
-81
- C3 -
3A1E
1
B:
[13-284]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
A
E
L
G
I
L
I
K
N
A
D
A
L
E
V
A
E
K
V
T
A
V
I
F
D
K
T
G
T
L
T
K
G
K
P
E
V
----
T
D
L
V
P
L
---
N
G
-
D
---------------------------------
E
------------------
R
----------------
E
-
L
L
R
L
A
A
I
A
E
R
----------------
R
S
E
Q
P
-----------------------
I
A
E
---------------------------------------
A
I
V
K
K
-
A
L
E
H
G
I
----------
E
L
------------
G
E
P
E
K
V
E
V
I
A
G
E
---
G
V
V
A
----------------------------------
D
---------
G
I
L
----------------
V
G
N
--------------
K
R
L
M
---------------------
E
D
--------
F
--
G
------------------
V
---
A
V
S
N
---------
E
V
E
L
A
L
E
K
L
E
R
E
A
K
-
T
A
V
I
V
A
------------------------
R
-----------------------
N
G
------------------------
R
V
E
G
I
I
A
V
S
D
T
L
K
E
S
A
K
P
A
V
Q
E
L
K
R
M
G
I
K
-
V
G
M
I
T
G
D
N
W
R
S
A
E
A
I
S
R
E
L
N
--------------------------------
L
------------------------------
D
------------------------------------------------------
L
V
I
A
E
V
L
------------------------
P
H
Q
K
S
E
E
V
K
K
L
Q
--
A
K
E
V
V
A
F
V
G
D
G
I
N
D
A
P
A
L
A
Q
A
D
L
G
I
A
V
G
-
S
G
S
D
V
A
V
E
S
G
D
I
V
L
I
R
D
D
L
R
D
V
V
A
A
I
Q
L
S
R
K
T
M
S
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
9
PsiBlast_PDB
65.89
37%
-82
- C3 -
3A1D
2
?
A:
[14-281]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------A
E
L
G
I
L
I
K
N
A
D
A
L
E
V
A
E
K
V
T
A
V
I
F
D
K
T
G
T
L
T
K
G
K
P
E
V
----
T
D
L
V
P
L
---
N
G
-
D
---------------------------------
E
------------------
R
----------------
E
-
L
L
R
L
A
A
I
A
E
R
----------------
R
S
E
H
P
-----------------------
I
A
E
---------------------------------------
A
I
V
K
K
-
A
L
E
H
G
I
----------
E
L
------------
G
E
P
E
K
V
E
V
I
A
G
E
---
G
V
V
A
----------------------------------
D
---------
G
I
L
----------------
V
G
N
--------------
K
R
L
M
---------------------
E
D
--------
F
--
G
------------------
V
---
A
V
S
N
---------
E
V
E
L
A
L
E
K
L
E
R
E
A
K
-
T
A
V
I
V
A
------------------------
R
-----------------------
N
G
------------------------
R
V
E
G
I
I
A
V
S
D
T
L
K
E
S
A
K
P
A
V
Q
E
L
K
R
M
G
I
K
-
V
G
M
I
T
G
D
N
W
R
S
A
E
A
I
S
R
E
L
N
--------------------------------
L
------------------------------
D
------------------------------------------------------
L
V
I
A
E
V
L
------------------------
P
H
Q
K
S
E
E
V
K
K
L
Q
--
A
K
E
V
V
A
F
V
G
D
G
I
N
D
A
P
A
L
A
Q
A
D
L
G
I
A
V
G
-
S
G
S
D
V
A
V
E
S
G
D
I
V
L
I
R
D
D
L
R
D
V
V
A
A
I
Q
L
S
R
K
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
10
PsiBlast_PDB
65.68
36%
-82
- C3 -
3A1E
2
COPA_ARCFU
A:
[14-281]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------A
E
L
G
I
L
I
K
N
A
D
A
L
E
V
A
E
K
V
T
A
V
I
F
D
K
T
G
T
L
T
K
G
K
P
E
V
----
T
D
L
V
P
L
---
N
G
-
D
---------------------------------
E
------------------
R
----------------
E
-
L
L
R
L
A
A
I
A
E
R
----------------
R
S
E
Q
P
-----------------------
I
A
E
---------------------------------------
A
I
V
K
K
-
A
L
E
H
G
I
----------
E
L
------------
G
E
P
E
K
V
E
V
I
A
G
E
---
G
V
V
A
----------------------------------
D
---------
G
I
L
----------------
V
G
N
--------------
K
R
L
M
---------------------
E
D
--------
F
--
G
------------------
V
---
A
V
S
N
---------
E
V
E
L
A
L
E
K
L
E
R
E
A
K
-
T
A
V
I
V
A
------------------------
R
-----------------------
N
G
------------------------
R
V
E
G
I
I
A
V
S
D
T
L
K
E
S
A
K
P
A
V
Q
E
L
K
R
M
G
I
K
-
V
G
M
I
T
G
D
N
W
R
S
A
E
A
I
S
R
E
L
N
--------------------------------
L
------------------------------
D
------------------------------------------------------
L
V
I
A
E
V
L
------------------------
P
H
Q
K
S
E
E
V
K
K
L
Q
--
A
K
E
V
V
A
F
V
G
D
G
I
N
D
A
P
A
L
A
Q
A
D
L
G
I
A
V
G
-
S
G
S
D
V
A
V
E
S
G
D
I
V
L
I
R
D
D
L
R
D
V
V
A
A
I
Q
L
S
R
K
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
8
PsiBlast_PDB
65.60
37%
-80
- C3 -
3A1C
2
?
A:
[14-280]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------A
E
L
G
I
L
I
K
N
A
D
A
L
E
V
A
E
K
V
T
A
V
I
F
D
K
T
G
T
L
T
K
G
K
P
E
V
----
T
D
L
V
P
L
---
N
G
-
D
---------------------------------
E
------------------
R
----------------
E
-
L
L
R
L
A
A
I
A
E
R
----------------
R
S
E
H
P
-----------------------
I
A
E
---------------------------------------
A
I
V
K
K
-
A
L
E
H
G
I
----------
E
L
------------
G
E
P
E
K
V
E
V
I
A
G
E
---
G
V
V
A
----------------------------------
D
---------
G
I
L
----------------
V
G
N
--------------
K
R
L
M
---------------------
E
D
--------
F
--
G
------------------
V
---
A
V
S
N
---------
E
V
E
L
A
L
E
K
L
E
R
E
A
K
-
T
A
V
I
V
A
------------------------
R
-----------------------
N
G
------------------------
R
V
E
G
I
I
A
V
S
D
T
L
K
E
S
A
K
P
A
V
Q
E
L
K
R
M
G
I
K
-
V
G
M
I
T
G
D
N
W
R
S
A
E
A
I
S
R
E
L
N
--------------------------------
L
------------------------------
D
------------------------------------------------------
L
V
I
A
E
V
L
------------------------
P
H
Q
K
S
E
E
V
K
K
L
Q
--
A
K
E
V
V
A
F
V
G
D
G
I
N
D
A
P
A
L
A
Q
A
D
L
G
I
A
V
G
-
S
G
S
D
V
A
V
E
S
G
D
I
V
L
I
R
D
D
L
R
D
V
V
A
A
I
Q
L
S
R
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
22
PsiBlast_CBE
65.48
37%
-81
- C3 -
3A1C
1
?
B:
[14-286]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------AELG
I
L
I
K
N
A
D
A
L
E
V
A
E
K
V
T
A
V
I
F
D
K
T
G
T
L
T
K
G
K
P
E
V
----
T
D
L
V
P
L
---
N
G
-
D
---------------------------------
E
------------------
R
----------------
E
-
L
L
R
L
A
A
I
A
E
R
----------------
R
S
E
H
P
-----------------------
I
A
E
---------------------------------------
A
I
V
K
K
-
A
L
E
H
G
I
----------
E
L
------------
G
E
P
E
K
V
E
V
I
A
G
E
---
G
V
V
A
----------------------------------
D
---------
G
I
L
----------------
V
G
N
--------------
K
R
L
M
---------------------
E
D
--------
F
--
G
------------------
V
---
A
V
S
N
---------
E
VELALEKLE
R
E
A
K
-
T
A
V
I
V
A
------------------------
R
-----------------------
N
G
------------------------
R
V
E
G
I
I
A
V
S
D
T
L
K
E
S
A
K
P
A
V
Q
E
L
K
R
M
G
I
K
-
V
G
M
I
T
G
D
N
W
R
S
A
E
A
I
S
R
E
L
N
--------------------------------
L
------------------------------
D
------------------------------------------------------
L
V
I
A
E
V
L
------------------------
P
H
Q
K
S
E
E
V
K
K
L
Q
--
A
K
E
V
V
A
F
V
G
D
G
I
N
D
A
P
A
L
A
Q
A
D
L
G
I
A
V
G
-
S
G
S
D
V
A
V
E
S
G
D
I
V
L
I
R
D
D
L
R
D
V
V
A
A
I
Q
L
S
R
K
T
M
S
K
I
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
118
HHSearch
65.31
38%
-74
- C3 -
3A1C
2
?
A:
[14-280]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
E
L
G
----
I
L
I
K
N
A
D
A
L
E
V
A
E
K
V
T
A
V
I
F
D
K
T
G
T
L
T
K
G
K
P
E
V
----
T
D
L
V
P
L
---
N
G
-----------------------------------
D
------------------
E
----------------
R
E
L
L
R
L
A
A
I
A
E
R
----------------
R
S
E
H
P
-----------------------
I
A
E
---------------------------------------
A
I
-
V
K
-
K
A
L
E
H
G
-------
I
--
E
L
------------
G
E
P
E
K
V
E
V
I
A
G
E
---
G
V
V
A
----------------------------------
D
---------
G
I
L
----------------
V
G
N
--------------
K
R
L
M
---------------------
E
D
--------
F
G
V
A
V
S
N
E
V
E
L
-----------
A
---
L
E
K
L
---------
E
---------
R
E
A
K
-
T
A
V
I
V
A
------------------------
R
-----------------------
N
G
------------------------
R
V
E
G
I
I
A
V
S
D
T
L
K
E
S
A
K
P
A
V
Q
E
L
K
R
M
G
I
K
-
V
G
M
I
T
G
D
N
W
R
S
A
E
A
I
S
R
E
L
N
--------------------------------
L
------------------------------
D
L
-----------------------------------------------------
V
I
-
A
E
V
L
------------------------
P
H
Q
K
S
E
E
V
K
K
L
Q
A
--
K
E
V
V
A
F
V
G
D
G
I
N
D
A
P
A
L
A
Q
A
D
L
G
I
A
V
G
-
S
G
S
D
V
A
V
E
S
G
D
I
V
L
I
R
D
D
L
R
D
V
V
A
A
I
Q
L
S
R
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
26
PsiBlast_CBE
59.88
31%
-68
- C3 -
2YJ5
1
?
B:
[12-253]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
G
----
M
I
I
K
N
S
N
V
Y
E
K
I
K
E
I
D
T
I
I
F
N
K
T
G
T
L
T
Y
G
T
P
I
V
----
T
Q
F
I
------
G
-
D
---------------------------------
S
------------------
L
----------------
S
--
L
A
Y
A
A
S
V
E
A
----------------
L
S
S
H
P
-----------------------
I
A
K
---------------------------------------
A
I
-
V
K
Y
A
K
E
Q
G
V
K
----------
I
------------
L
E
V
K
D
F
K
E
I
S
G
I
---
G
V
R
G
K
I
----
S
----------------
D
----------
K
---------
I
I
------------------------------------------------------------------------------------------------
E
V
K
---------
K
---------
A
E
N
N
-
N
D
I
A
V
Y
------------------------
I
-----------------------
N
G
------------------------
E
P
I
A
S
F
N
I
S
D
V
P
R
P
N
L
K
D
Y
L
E
K
L
K
N
E
G
L
K
-
I
I
I
L
S
G
D
K
E
D
K
V
K
E
L
S
K
E
L
N
--------------------------------
I
Q-----------------------------
E
------------------------------------------------------
Y
Y
-
S
N
L
S
------------------------
P
E
D
K
V
R
I
I
E
K
L
K
Q
N
G
N
K
-
V
L
M
I
G
D
G
V
N
D
A
A
A
L
A
L
A
D
V
S
V
A
M
G
-
N
G
V
D
I
S
K
N
V
A
D
I
I
L
V
S
N
D
I
G
T
L
L
G
L
I
K
N
R
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
27
PsiBlast_CBE
59.28
31%
-59
- C3 -
2YJ4
1
?
B:
[12-253]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
G
----
M
I
I
K
N
S
N
V
Y
E
K
I
K
E
I
D
T
I
I
F
N
K
T
G
T
L
T
Y
G
T
P
I
V
----
T
Q
F
I
------
G
-
D
---------------------------------
S
------------------
L
----------------
S
--
L
A
Y
A
A
S
V
E
A
----------------
L
S
S
H
P
-----------------------
I
A
K
---------------------------------------
A
I
-
V
K
Y
A
K
E
Q
G
V
K
----------
I
------------
L
E
V
K
D
F
K
E
I
S
G
I
---
G
V
R
G
K
I
----
S
----------------
D
----------
K
---------
I
I
------------------------------------------------------------------------------------------------
E
V
K
---------
K
---------
A
E
N
N
-
N
D
I
A
V
Y
------------------------
I
-----------------------
N
G
------------------------
E
P
I
A
S
F
N
I
S
D
V
P
R
P
N
L
K
D
Y
L
E
K
L
K
N
E
G
L
K
-
I
I
I
L
S
G
D
K
E
D
K
V
K
E
L
S
K
E
L
N
--------------------------------
I
Q-----------------------------
E
------------------------------------------------------
Y
Y
-
S
N
L
S
------------------------
P
E
D
K
V
R
I
I
E
K
L
K
Q
N
G
N
K
-
V
L
M
I
G
D
G
V
N
D
A
A
A
L
A
L
A
D
V
S
V
A
M
G
-
N
G
V
D
I
S
K
N
V
A
D
I
I
L
V
S
N
D
I
G
T
L
L
G
L
I
K
N
R
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------