@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : jhp_1164: (2015-12-21 )
MKKTLLLSLSLSFGLHAEDDGFYASAGIRIGEAAQMVKNTKGIQQLSENYEKLNNLLNNYNTLNTLVKLSSDPSAVNDARDNLGSSTRNLLDVKANSPAYQAVLLALNAAVGLWQVTSYAFTACGPGSNENANGGIQTFNNVPGQNTTTITCNSYYEPGHGGPISTKNYAIINKAYQIIQKALTANGEGIPVLSNTTTKLDFTINGDKRTGGEPNKKLVYPWSHGKAISTSWNATITAPTTENINTTNSAQELLKQASIIITTLNSACPNFQNGGSGYWAGISGNGTMCGMFKNEISAIQGMIANAQEAVAQAKIVSENTQNQNSLDAGKPFNPYTDASFAESMLKNAQAQAEILNQAEQVVKNFEKIPTAFVNDSLGVCYEVQGGERRGTNPGQTTSNTWGAGCAYVGQTITNLKNSIAHFGTQEQQIQQAENIADTLVNFKSRYSELGNTYNSITTALSNIPNAQSLQNAVSKKNNPYSPQGIDTNYYLNQNSYNQIQTINQELGRNPFRKVGIVSSQTNNGAMNGIGIQVGYKQFFGQKRKWGARYYGFFDYNHAFIKSSFFNSASDVWTYGFGADALYNFINDKATNFLGKNNKLSVGLFGGIALAGTSWLNSEYVNLATMNNVYNAKMNVANFQFLFNMGVRMNLARPKKKDSDHAAQHGIELGLKIPTINTNYYSFMGAELKYRRLYSVYLNYVFAY
Atome Classification :
(20 SA)
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------.........10........20........30........40........50........60........70........80........90........100.......110.......120.......130......-.140.......150.-......160.......170.......180.......190.......200---.--.....-------..210....---...220.......230.......240.....---------------..250.......260.......270.......280---.......290.......300.......310.......320----........330.......340.......350.......360.--......370---.......380-.........390.......400.......410.......420...-....430.......440.......450.......460.-......470.......480.......490.......500.......510.......520.......530.......540.......550.......560.......570.......580.......590.......600.......610.......620.......630.......640.......650.......660.......670.......680.......690.......700.
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MK
K
T
L
L
L
S
L
S
L
S
FGLHAEDDG
F
Y
ASAGIRI
G
E
A
A
Q
M
V
K
N
T
K
G
I
Q
Q
L
S
E
N
Y
E
K
L
N
N
L
L
NNY
N
T
L
N
T
L
V
KLSSDPSA
V
N
D
A
R
D
NLGSSTR
N
L
L
D
VKANS
P
A
Y
Q
A
V
L
L
A
L
N
A
A
V
G
L
W
Q
V
T
S
Y
A
F
TACGPGSNENANGG
I
Q
T-FNNVPGQ
N
T
T
T
I
T
CN-SYYEPGHGGPISTK
N
Y
A
I
I
N
K
A
Y
Q
I
I
Q
K
A
L
TANGEG
I
P
V
LSNT
T
T
K
L
D
----
F
--
T
INGD-------KRTGGEPNK---
K
L
V
Y
PWSHG
K
A
I
STSW
N
A
T
I
TAPTTENINT
T
---------------
N
S
A
Q
E
L
L
K
QA
S
I
I
I
T
T
L
N
SACPNFQNGGS
G
Y
W
A
GI---SGNG
T
M
C
G
M
F
K
N
E
I
S
A
I
Q
G
M
I
A
N
A
Q
E
A
V
A
Q
A
K
I
VSENTQ-----NQNSLDAGKPFNPYT
D
A
S
F
A
E
S
M
L
K
N
A
Q
A
Q
A
E
I
L
N
Q
A
E
Q
V
V
K
--
N
F
E
KI
P
T
A
F
---VNDSL
G
V
C
---
Y
E
VQGGERRGTNPGQTTSNTWG
A
G
C
A
Y
V
G
Q
T
I
T
N
L
K
N
S
I
A
HFG
T
Q
-
E
Q
Q
I
Q
Q
A
E
N
I
A
D
T
L
V
N
F
K
S
R
Y
S
E
LG
N
T
Y
N
S
I
T
T
A
L
SNI-P
N
A
Q
S
L
Q
N
A
V
SKKNNPYSPQGIDT
N
Y
Y
LNQNSY
N
Q
I
Q
T
I
N
Q
E
LGRNPFRKVG
I
V
SSQTNNGAM
N
G
I
G
I
Q
V
G
Y
K
Q
FFGQKRKWGA
R
Y
Y
G
F
FDY
N
H
A
F
I
K
S
S
FFNSASD
V
W
TYGF
G
A
D
A
L
Y
N
F
I
N
D
K
A
T
N
FLGKNN
K
L
S
V
G
L
FG
G
I
A
L
AGTSWLNSE
Y
V
N
L
A
T
MNNVYNAKMNVA
N
F
Q
F
L
FNMG
V
R
M
NLARPKKKDS
D
H
A
A
QHG
I
E
L
G
L
K
IPTINT
N
Y
Y
S
FMGA
E
L
K
Y
R
R
L
Y
S
V
Y
L
N
Y
V
FAY
1
PsiBlast_PDB
99.64
54%
-65
- C3 -
4ZH7
4
?
A:
[18-518]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
D
L
S
D
R
Y
E
S
L
N
N
L
L
N
R
Y
S
T
L
N
T
L
I
K
L
S
A
D
P
S
A
I
N
A
V
R
E
N
L
G
A
S
A
K
N
L
I
G
D
K
A
N
S
P
A
Y
Q
A
V
L
L
A
I
N
A
A
V
G
F
W
N
V
V
G
Y
-
V
T
Q
C
G
G
N
A
N
G
Q
K
S
I
S
S
K
T
I
F
N
N
E
P
G
Y
R
S
T
S
I
T
C
S
L
N
G
H
S
P
G
Y
Y
G
P
M
S
I
E
N
F
K
K
L
N
E
A
Y
Q
I
L
Q
T
A
L
K
---
R
G
L
P
A
L
K
E
N
N
G
K
V
N
V
T
Y
T
Y
--
T
C
S
G
D
GNNNCSS
Q
V
T
G
V
N
N
Q
K
D
G
T
K
T
K
I
Q
T
I
D
G
K
S
V
T
T
T
I
S
S
K
V
V
D
S
R
A
D
G
-
N
T
T
G
V
S
Y
T
E
I
T
N
K
L
E
GVP
D
S
A
Q
A
L
L
A
Q
A
S
T
L
I
N
T
I
N
N
A
C
P
Y
F
H
A
---------FS-
T
T
T
G
K
I
C
G
A
F
S
E
E
I
S
A
I
Q
K
M
I
T
D
A
Q
E
L
V
N
Q
T
S
V
I
N
E
H
E
Q
T
T
P
V
G
N
N
N
----
G
K
P
F
N
P
F
T
D
A
S
F
A
Q
G
M
L
A
N
A
S
A
Q
A
K
M
L
N
L
A
E
Q
V
G
Q
A
I
N
P
E
R
L
S
G
T
F
Q
N
F
V
K
G
F
L
A
T
C
NNP
S
-------
Q
G
S
A
P
G
T
V
T
T
Q
T
F
A
S
G
C
A
Y
V
G
Q
T
I
T
N
L
K
N
S
I
A
H
F
G
T
Q
-
E
Q
Q
I
Q
Q
A
E
N
I
A
D
T
L
V
N
F
K
S
R
Y
S
E
L
G
N
T
Y
N
S
I
T
T
A
L
S
N
I
-
P
N
A
Q
S
L
Q
N
A
V
S
K
K
N
N
P
Y
S
P
Q
G
I
D
T
N
Y
Y
L
N
Q
N
S
Y
N
Q
I
Q
T
I
N
Q
E
L
K
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
2
PsiBlast_PDB
85.80
54%
5
- C3 -
4ZH0
-
?
A:
[18-518]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
D
L
S
D
R
Y
E
S
L
N
N
L
L
N
R
Y
S
T
L
N
T
L
I
K
L
S
A
D
P
S
A
I
N
A
V
R
E
N
L
G
A
S
A
K
N
L
I
G
D
K
A
N
S
P
A
Y
Q
A
V
L
L
A
I
N
A
A
V
G
F
W
N
V
V
G
Y
-
V
T
Q
C
G
G
N
A
N
G
Q
K
S
I
S
S
K
T
I
F
N
N
E
P
G
Y
R
S
T
S
I
T
C
S
L
N
G
H
S
P
G
Y
Y
G
P
M
S
I
E
N
F
K
K
L
N
E
A
Y
Q
I
L
Q
T
A
L
K
---
R
G
L
P
A
L
K
E
N
N
G
K
V
N
V
T
Y
T
Y
--
T
C
S
G
D
GNNNCSS
Q
V
T
G
V
N
N
Q
K
D
G
T
K
T
K
I
Q
T
I
D
G
K
S
V
T
T
T
I
S
S
K
V
V
D
S
R
A
D
G
-
N
T
T
G
V
S
Y
T
E
I
T
N
K
L
E
GVP
D
S
A
Q
A
L
L
A
Q
A
S
T
L
I
N
T
I
N
N
A
C
P
Y
F
H
A
--------
P
KFS
T
T
T
G
K
I
C
G
A
F
S
E
E
I
S
A
I
Q
K
M
I
T
D
A
Q
E
L
V
N
Q
T
S
V
I
N
E
H
E
Q
T
T
P
V
G
N
N
N
----
G
K
P
F
N
P
F
T
D
A
S
F
A
Q
G
M
L
A
N
A
S
A
Q
A
K
M
L
N
L
A
E
Q
V
G
Q
A
I
N
P
E
R
L
S
G
T
F
Q
N
F
V
K
G
F
L
A
T
C
NNP
S
-------
Q
G
S
A
P
G
T
V
T
T
Q
T
F
A
S
G
C
A
Y
V
G
Q
T
I
T
N
L
K
N
S
I
A
H
F
G
T
Q
-
E
Q
Q
I
Q
Q
A
E
N
I
A
D
T
L
V
N
F
K
S
R
Y
S
E
L
G
N
T
Y
N
S
I
T
T
A
L
S
N
I
-
P
N
A
Q
S
L
Q
N
A
V
S
K
K
N
N
P
Y
S
P
Q
G
I
D
T
N
Y
Y
L
N
Q
N
S
Y
N
Q
I
Q
T
I
N
Q
E
L
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
38
Fugue
70.10
22%
-41
- C3 -
4O5J
3
?
A:
[27-400]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
K
N
L
N
E
K
Y
E
Q
L
S
Q
Y
L
N
Q
V
A
S
L
K
Q
S
I
Q
N
A
N
N
I
E
L
V
N
S
S
L
N
Y
L
K
S
F
T
N
N
N
Y
N
S
T
T
Q
S
P
I
F
N
A
V
Q
A
V
I
T
S
V
L
G
F
W
S
L
Y
A
G
N
Y
F
T
F
F
V
G
K
K
V
D
S
G
Q
P
A
S
V
-
Q
G
N
-
P
P
F
K
T
I
I
E
N
C
S
-
G
I
----
E
N
C
A
M
D
Q
T
T
Y
D
K
M
K
K
L
A
E
D
L
Q
A
A
Q
T
----------
N
S
A
T
K
G
N
----
N
LC
A
L
S
G
C
-------
A
A
T
S
N
P
P
N
S
---
T
V
S
N
A
L
N
L
A
Q
Q
L
M
D
L
I
A
N
T
K
T
A
M
M
W
K
N
I
V
I
S
---------------
G
V
S
N
T
-----
S
G
A
I
T
S
T
N
----------------------
Y
P
T
Q
Y
A
V
F
N
N
----
I
K
A
M
I
P
I
L
Q
Q
A
V
T
L
S
Q
S
N
H
T
L
S
A
-----
S
L
Q
A
Q
A
T
G
----
S
Q
T
N
P
K
F
A
K
D
I
Y
T
F
A
Q
N
Q
K
Q
V
I
S
Y
A
Q
D
I
F
N
--
L
F
N
S
I
P
----------
A
E
Q
Y
---
K
Y
L
E
K
A
Y
L
K
I
P
N
A
G
S
T
P
T
N
P
Y
-
R
Q
V
V
N
L
N
Q
E
V
Q
T
I
K
N
N
V
S
Y
Y
G
----
N
R
V
D
A
A
L
S
V
A
R
D
V
Y
N
L
K
S
N
Q
A
E
I
V
T
A
Y
N
D
A
K
T
L
S
E
E
I
-
S
K
L
P
H
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
43
Fugue
43.37
8%
5
- C3 -
2YFA
4
MCPS_PSEPK
A:
[18-253]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
S
H
M
G
D
I
G
Q
L
N
K
D
L
T
D
L
R
I
A
R
L
Q
Y
M
I
A
N
-
G
D
D
T
A
A
---
A
N
T
L
A
K
L
D
A
F
S
K
Q
Q
A
Y
L
A
T
T
F
K
S
P
E
N
V
K
L
L
G
E
L
G
D
T
I
S
A
-----
Y
K
L
S
L
N
K
M
R
Q
-
G
Y
D
A
T
R
A
A
R
V
S
M
D
S
S
A
I
R
A
D
Q
A
M
D
A
L
S
Q
E
V
M
--
A
R
P
E
A
D
S
V
R
---
L
A
Q
Y
Q
L
I
S
---
K
A
R
Q
Q
L
L
Q
V
R
I
D
V
R
G
Y
I
A
E
N
S
S
A
N
E
Q
A
A
L
R
Q
L
D
A
A
L
A
D
T
D
N
L
K
R
Q
L
P
S
E
D
A
R
L
Q
Q
F
E
N
A
V
L
A
Y
R
D
A
V
R
Q
F
R
D
A
V
A
N
I
T
T
S
R
A
E
M
T
V
Q
G
A
D
I
V
K
R
S
D
A
L
Y
Q
I
Q
L
E
R
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
42
Fugue
42.80
7%
9
- C3 -
1ST6
-
VINC_CHICK
A:
[-2-1065]
RMPVFHT
R
T
I
E
S
I
L
E
P
V
A
Q
Q
I
S
H
L
V
I
M
H
E
E
G
E
V
DGKAIPDL
T
A
P
V
S
A
V
Q
A
A
V
S
N
L
V
R
V
G
K
E
T
V
Q
T
TED
Q
I
L
K
R
D
M
P
P
A
F
I
K
V
E
N
A
C
T
K
L
V
R
A
A
Q
M
L
Q
A
DPYS
V
P
A
R
D
Y
L
I
D
G
S
R
G
I
L
S
G
T
S
D
L
L
L
T
F
D
E
A
E
V
R
K
I
I
R
V
C
K
G
I
L
E
Y
L
T
V
AEVVET
M
E
D
L
V
T
Y
T
K
N
L
G
P
G
M
T
K
M
A
K
M
I
D
E
R
Q
Q
E
LTH
Q
E
H
R
V
M
L
V
N
S
M
N
T
V
K
E
L
L
P
V
L
I
S
A
M
K
I
F
V
T
T
K
N
TKSQG
I
E
E
A
L
K
N
R
N
F
T
V
E
K
M
S
A
E
I
N
E
I
I
R
V
L
Q
LTSWD
E
D
A
W
A
S
K
D
T
E
A
M
K
R
A
L
A
L
I
D
S
K
M
N
Q
A
K
G
W
L
R
D
PNAPPGD
A
G
E
Q
A
I
R
Q
I
L
D
E
A
G
K
A
G
E
L
CA
G
K
E
R
R
E
I
L
G
T
C
K
T
L
G
Q
M
T
D
Q
L
A
D
LRARGQGAT
P
M
A
M
Q
K
A
Q
Q
V
S
Q
G
L
D
L
L
T
A
K
V
E
N
A
A
R
K
L
E
A
M
T
N
S
K
Q
A
I
A
K
K
I
D
A
A
Q
N
W
L
A
D
P
N
G
G
S
E
G
E
E
H
I
R
G
I
M
S
E
A
R
K
V
A
E
L
C
E
E
P
K
E
R
D
D
I
L
R
S
L
G
E
I
S
A
L
T
A
K
L
S
D
L
R
R
H
G
K
G
D
S
P
E
A
R
A
L
A
K
Q
I
A
T
S
L
Q
N
L
Q
S
K
T
N
R
A
V
A
N
T
R
P
V
K
A
A
V
H
L
-
E
G
K
I
E
Q
A
Q
R
W
I
D
N
P
T
-
V
D
D
R
G
V
G
Q
A
A
I
R
G
L
V
A
E
G
R
R
L
A
N
V
M
M
G
P
Y
R
Q
D
L
L
A
K
C
D
R
V
D
Q
L
A
A
Q
L
A
----
D
--
L
A
A
R
G
-------
E
G
E
S
P
Q
A
R
A
---
I
A
A
Q
L
Q
D
S
L
K
D
L
K
A
R
M
Q
E
A
M
T
Q
E
V
S
D
V
F
S
D
T
---------------
T
T
P
I
K
L
L
A
V
A
A
T
A
P
S
D
T
P
N
R
E
E
V
F
E
E
R
A
A
N
F
E
N
H
A
---
A
R
L
G
A
T
A
E
K
A
A
A
V
G
T
A
N
K
T
T
V
E
G
I
Q
A
T
V
K
S
A
R
E
L
T
P
Q
V
V
-----
S
A
A
R
I
L
L
R
N
P
G
N
Q
A
A
Y
E
H
F
E
T
M
K
N
Q
W
I
D
N
V
E
K
M
T
G
L
V
D
E
A
I
D
--
T
K
S
L
L
D
A
S
E
---
E
A
I
K
K
D
L
D
---
K
C
K
V
A
M
A
N
M
Q
P
Q
M
L
V
A
G
A
T
S
I
A
R
R
A
N
R
I
L
L
V
A
K
R
E
V
E
N
S
E
D
P
K
F
R
-
E
A
V
K
A
A
S
D
E
L
S
K
T
I
S
P
M
V
M
D
A
K
A
V
A
G
N
I
S
D
P
G
L
Q
K
S
F
L
-
D
S
G
Y
R
I
L
G
A
V
A
K
V
R
E
A
F
Q
P
Q
E
P
D
F
P
P
P
P
P
D
L
E
H
L
H
L
T
P
P
P
P
E
E
K
D
E
E
F
-------
P
E
Q
K
A
G
E
A
I
N
Q
P
M
M
M
A
A
R
Q
L
H
D
E
A
R
K
W
S
S
K
G
N
D
I
I
A
A
A
K
R
M
A
L
L
M
A
E
M
S
R
-----
L
V
R
G
G
S
G
N
K
R
A
L
I
Q
C
A
K
D
I
A
K
A
S
D
E
V
T
R
L
A
K
E
V
A
K
Q
C
T
D
K
R
I
R
T
N
L
L
Q
V
C
E
R
I
P
T
I
S
T
Q
L
K
I
L
S
T
V
K
A
T
M
L
G
R
T
N
I
S
D
E
E
S
E
Q
A
T
E
M
L
V
H
N
A
Q
N
L
M
Q
S
V
K
E
T
V
R
E
A
E
A
A
S
I
K
I
R
T
D
A
G
F
T
L
R
W
V
R
K
T
P
W
Y
40
Fugue
41.83
10%
15
- C3 -
4ABX
-
RECN_DEIRA
A:
[-1-360]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
Q
R
E
R
A
R
Q
I
D
L
L
A
F
Q
V
Q
-----
E
I
S
E
V
S
P
D
P
--
G
E
E
E
G
L
N
T
E
L
S
R
L
S
N
L
H
T
I
A
Q
A
A
A
G
G
V
E
L
L
S
--
D
G
D
L
N
A
A
G
L
---
I
G
E
A
V
R
A
L
---
N
A
G
A
----
K
Y
D
E
T
V
M
Q
L
Q
N
E
L
R
A
A
L
E
S
V
Q
A
I
A
G
E
L
R
D
V
A
E
G
S
A
A
D
-
P
E
A
L
D
R
V
E
A
R
L
S
A
L
S
K
L
K
N
K
Y
---
G
P
T
L
E
D
V
V
E
F
G
A
Q
A
-
A
E
E
L
A
G
L
E
E
D
E
R
D
A
G
S
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
3
PsiBlast_PDB
39.98
37%
10
- C3 -
4O5J
2
?
A:
[27-100]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
K
N
L
N
E
K
Y
E
Q
L
S
Q
Y
L
N
Q
V
A
S
L
K
Q
S
I
Q
N
A
N
N
I
E
L
V
N
S
S
L
N
Y
L
K
S
F
T
N
N
N
Y
N
S
T
T
Q
S
P
I
F
N
A
V
Q
A
V
I
T
S
V
L
G
F
W
S
L
Y
A
G
N
Y
F
T
F
F
V
G
K
K
V
D
S
G
Q
P
A
S
V
-
Q
G
N
P
P
F
K
T
I
I
E
N
C
S
G
-
I
E
N
C
A
M
D
Q
T
T
Y
D
K
M
K
K
L
A
E
D
L
Q
A
A
Q
T
N
S
A
T
K
G
N
N
L
C
A
L
S
G
C
A
A
T
S
N
P
P
----
N
--
S
T
V
S
N
-------
A
L
N
L
A
Q
Q
L
M
---
D
L
I
A
N
T
K
T
A
M
M
W
K
N
I
V
I
S
G
V
S
N
T
S
G
A
I
T
S
T
N
---------------
Y
P
T
Q
Y
A
V
F
N
N
I
K
A
M
I
P
I
L
Q
Q
A
V
T
L
S
Q
S
N
H
T
L
S
A
S
L
---
Q
A
Q
A
T
G
S
Q
T
N
P
K
F
A
K
D
I
Y
T
F
A
Q
N
Q
K
Q
V
I
S
Y
A
Q
D
I
F
N
L
F
N
-----
S
I
P
A
E
Q
Y
K
Y
L
E
K
A
Y
L
K
I
P
N
A
G
S
T
P
T
N
P
Y
R
Q
V
V
N
L
N
Q
E
V
Q
T
I
K
--
N
N
V
S
Y
Y
G
N
R
---
V
D
A
A
L
S
V
A
---
R
D
V
Y
N
L
K
S
N
Q
A
E
I
V
T
A
Y
N
D
A
K
T
L
S
E
E
I
S
K
L
P
H
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
24
PsiBlast_CBE
38.19
38%
42
- C2 -
2X2H
1
?
B:
[412-450]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
T
K
G
E
----
F
--
W
T
A
N
R
-------
V
G
T
G
G
D
P
N
N
---
R
S
V
F
E
W
A
H
D
K
G
L
V
C
Q
T
N
I
T
C
F
L
R
N
D
N
E
G
Q
D
Y
---------------
E
V
N
Q
T
L
R
E
R
Q
L
Y
T
K
N
D
S
L
T
G
T
D
F
G
M
T
D
D
G
P
S
D
A
Y
I
---
G
H
L
D
Y
G
G
G
V
E
C
D
A
L
F
P
D
W
G
R
P
D
V
A
E
W
W
G
N
N
Y
K
K
L
F
S
I
G
L
-----
D
F
V
W
Q
D
M
T
V
P
A
M
M
P
H
K
I
G
D
D
I
N
V
K
P
D
G
N
W
P
N
A
D
D
P
S
N
G
Q
Y
N
W
--
K
T
Y
H
P
Q
V
L
V
---
T
D
M
R
Y
E
N
H
---
G
R
E
P
M
V
T
Q
R
N
I
H
A
Y
T
L
C
E
S
T
R
K
E
G
I
V
E
N
A
D
T
L
T
K
F
R
R
S
Y
I
I
S
R
G
G
-
Y
I
G
N
Q
H
F
G
G
M
W
V
G
D
N
S
T
T
S
N
Y
I
Q
M
M
I
A
N
N
I
N
M
N
M
S
C
L
P
-
L
V
G
S
D
I
G
G
F
T
S
Y
D
N
E
N
Q
R
T
P
C
T
G
D
L
M
V
R
Y
V
Q
A
G
C
L
L
P
W
F
R
N
H
Y
D
R
W
I
E
S
K
D
H
G
K
D
Y
Q
E
L
Y
M
Y
P
N
E
M
D
T
L
R
K
F
V
E
F
R
Y
R
W
Q
E
V
L
Y
T
A
M
Y
Q
N
A
A
F
G
K
P
I
I
K
A
A
S
M
Y
N
N
D
S
N
V
R
R
A
Q
N
D
H
F
L
L
G
G
H
D
G
Y
R
I
L
C
A
P
V
V
W
E
N
S
T
E
R
E
L
Y
L
P
V
L
T
Q
W
Y
K
F
G
P
D
F
D
T
K
P
L
E
G
A
M
N
G
G
D
R
I
Y
N
Y
P
V
P
Q
S
E
S
P
I
F
V
R
E
G
A
I
L
P
T
R
Y
T
L
N
G
E
N
K
S
L
N
T
Y
T
D
E
D
P
L
V
F
E
V
F
P
L
G
N
N
R
A
D
G
M
C
Y
L
D
D
G
G
V
T
T
30
HHSearch
38.10
15%
2
- C4 -
1P4T
7
?
A:
[24-155]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
K
G
F
S
P
R
I
S
A
G
Y
R
--
I
N
--
D
-
L
R
F
A
----
V
D
Y
T
R
Y
K
N
Y
K
A
---
P
S
T
D
F
K
L
Y
S
I
G
A
S
A
I
Y
D
F
D
T
Q
S
-----------
P
V
K
P
Y
L
G
A
R
L
S
L
N
R
A
S
V
D
L
G
G
---------
S
D
S
F
S
Q
T
S
I
G
L
G
V
L
T
G
V
S
Y
A
V
T
----------
P
N
V
D
L
D
A
G
Y
R
Y
N
Y
I
G
K
V
N
--
T
---
V
K
-
N
V
R
S
G
E
L
S
A
G
V
R
V
K
F
12
PsiBlast_CBE
38.05
38%
45
- C2 -
4AMX
1
?
B:
[412-450]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
T
K
G
E
----
F
--
W
T
A
N
R
-------
V
G
T
G
G
D
P
N
N
---
R
S
V
F
E
W
A
H
D
K
G
L
V
C
Q
T
N
I
T
C
F
L
R
N
D
N
E
G
Q
D
Y
---------------
E
V
N
Q
T
L
R
E
R
Q
L
Y
T
K
N
D
S
L
T
G
T
D
F
G
M
T
D
D
G
P
S
D
A
Y
I
---
G
H
L
D
Y
G
G
G
V
E
C
D
A
L
F
P
D
W
G
R
P
D
V
A
E
W
W
G
N
N
Y
K
K
L
F
S
I
G
L
-----
D
F
V
W
Q
D
M
T
V
P
A
M
M
P
H
K
I
G
D
D
I
N
V
K
P
D
G
N
W
P
N
A
D
D
P
S
N
G
Q
Y
N
W
--
K
T
Y
H
P
Q
V
L
V
---
T
D
M
R
Y
E
N
H
---
G
R
E
P
M
V
T
Q
R
N
I
H
A
Y
T
L
C
E
S
T
R
K
E
G
I
V
E
N
A
D
T
L
T
K
F
R
R
S
Y
I
I
S
R
G
G
-
Y
I
G
N
Q
H
F
G
G
M
W
V
G
D
N
S
T
T
S
N
Y
I
Q
M
M
I
A
N
N
I
N
M
N
M
S
C
L
P
-
L
V
G
S
D
I
G
G
F
T
S
Y
D
N
E
N
Q
R
T
P
C
T
G
D
L
M
V
R
Y
V
Q
A
G
C
L
L
P
W
F
R
N
H
Y
D
R
W
I
E
S
K
D
H
G
K
D
Y
Q
E
L
Y
M
Y
P
N
E
M
D
T
L
R
K
F
V
E
F
R
Y
R
W
Q
E
V
L
Y
T
A
M
Y
Q
N
A
A
F
G
K
P
I
I
K
A
A
S
M
Y
N
N
D
S
N
V
R
R
A
Q
N
D
H
F
L
L
G
G
H
D
G
Y
R
I
L
C
A
P
V
V
W
E
N
S
T
E
R
E
L
Y
L
P
V
L
T
Q
W
Y
K
F
G
P
D
F
D
T
K
P
L
E
G
A
M
N
G
G
D
R
I
Y
N
Y
P
V
P
Q
S
E
S
P
I
F
V
R
E
G
A
I
L
P
T
R
Y
T
L
N
G
E
N
K
S
L
N
T
Y
T
D
E
D
P
L
V
F
E
V
F
P
L
G
N
N
R
A
D
G
M
C
Y
L
D
D
G
G
V
T
T
21
PsiBlast_CBE
37.68
38%
48
- C2 -
2X2I
1
?
B:
[412-450]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
T
K
G
E
----
F
--
W
T
A
N
R
-------
V
G
T
G
G
D
P
N
N
---
R
S
V
F
E
W
A
H
D
K
G
L
V
C
Q
T
N
I
T
C
F
L
R
N
D
N
E
G
Q
D
Y
---------------
E
V
N
Q
T
L
R
E
R
Q
L
Y
T
K
N
D
S
L
T
G
T
D
F
G
M
T
D
D
G
P
S
D
A
Y
I
---
G
H
L
D
Y
G
G
G
V
E
C
D
A
L
F
P
D
W
G
R
P
D
V
A
E
W
W
G
N
N
Y
K
K
L
F
S
I
G
L
-----
D
F
V
W
Q
D
M
T
V
P
A
M
M
P
H
K
I
G
D
D
I
N
V
K
P
D
G
N
W
P
N
A
D
D
P
S
N
G
Q
Y
N
W
--
K
T
Y
H
P
Q
V
L
V
---
T
D
M
R
Y
E
N
H
---
G
R
E
P
M
V
T
Q
R
N
I
H
A
Y
T
L
C
E
S
T
R
K
E
G
I
V
E
N
A
D
T
L
T
K
F
R
R
S
Y
I
I
S
R
G
G
-
Y
I
G
N
Q
H
F
G
G
M
W
V
G
D
N
S
T
T
S
N
Y
I
Q
M
M
I
A
N
N
I
N
M
N
M
S
C
L
P
-
L
V
G
S
D
I
G
G
F
T
S
Y
D
N
E
N
Q
R
T
P
C
T
G
D
L
M
V
R
Y
V
Q
A
G
C
L
L
P
W
F
R
N
H
Y
D
R
W
I
E
S
K
D
H
G
K
D
Y
Q
E
L
Y
M
Y
P
N
E
M
D
T
L
R
K
F
V
E
F
R
Y
R
W
Q
E
V
L
Y
T
A
M
Y
Q
N
A
A
F
G
K
P
I
I
K
A
A
S
M
Y
N
N
D
S
N
V
R
R
A
Q
N
D
H
F
L
L
G
G
H
D
G
Y
R
I
L
C
A
P
V
V
W
E
N
S
T
E
R
E
L
Y
L
P
V
L
T
Q
W
Y
K
F
G
P
D
F
D
T
K
P
L
E
G
A
M
N
G
G
D
R
I
Y
N
Y
P
V
P
Q
S
E
S
P
I
F
V
R
E
G
A
I
L
P
T
R
Y
T
L
N
G
E
N
K
S
L
N
T
Y
T
D
E
D
P
L
V
F
E
V
F
P
L
G
N
N
R
A
D
G
M
C
Y
L
D
D
G
G
V
T
T
16
PsiBlast_CBE
37.54
38%
32
- C2 -
2X2J
1
?
D:
[412-450]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
T
K
G
E
----
F
--
W
T
A
N
R
-------
V
G
T
G
G
D
P
N
N
---
R
S
V
F
E
W
A
H
D
K
G
L
V
C
Q
T
N
I
T
C
F
L
R
N
D
N
E
G
Q
D
Y
---------------
E
V
N
Q
T
L
R
E
R
Q
L
Y
T
K
N
D
S
L
T
G
T
D
F
G
M
T
D
D
G
P
S
D
A
Y
I
---
G
H
L
D
Y
G
G
G
V
E
C
D
A
L
F
P
D
W
G
R
P
D
V
A
E
W
W
G
N
N
Y
K
K
L
F
S
I
G
L
-----
D
F
V
W
Q
D
M
T
V
P
A
M
M
P
H
K
I
G
D
D
I
N
V
K
P
D
G
N
W
P
N
A
D
D
P
S
N
G
Q
Y
N
W
--
K
T
Y
H
P
Q
V
L
V
---
T
D
M
R
Y
E
N
H
---
G
R
E
P
M
V
T
Q
R
N
I
H
A
Y
T
L
C
E
S
T
R
K
E
G
I
V
E
N
A
D
T
L
T
K
F
R
R
S
Y
I
I
S
R
G
G
-
Y
I
G
N
Q
H
F
G
G
M
W
V
G
D
N
S
T
T
S
N
Y
I
Q
M
M
I
A
N
N
I
N
M
N
M
S
C
L
P
-
L
V
G
S
D
I
G
G
F
T
S
Y
D
N
E
N
Q
R
T
P
C
T
G
D
L
M
V
R
Y
V
Q
A
G
C
L
L
P
W
F
R
N
H
Y
D
R
W
I
E
S
K
D
H
G
K
D
Y
Q
E
L
Y
M
Y
P
N
E
M
D
T
L
R
K
F
V
E
F
R
Y
R
W
Q
E
V
L
Y
T
A
M
Y
Q
N
A
A
F
G
K
P
I
I
K
A
A
S
M
Y
N
N
D
S
N
V
R
R
A
Q
N
D
H
F
L
L
G
G
H
D
G
Y
R
I
L
C
A
P
V
V
W
E
N
S
T
E
R
E
L
Y
L
P
V
L
T
Q
W
Y
K
F
G
P
D
F
D
T
K
P
L
E
G
A
M
N
G
G
D
R
I
Y
N
Y
P
V
P
Q
S
E
S
P
I
F
V
R
E
G
A
I
L
P
T
R
Y
T
L
N
G
E
N
K
S
L
N
T
Y
T
D
E
D
P
L
V
F
E
V
F
P
L
G
N
N
R
A
D
G
M
C
Y
L
D
D
G
G
V
T
T
14
PsiBlast_CBE
36.95
38%
41
- C2 -
4AMW
1
?
C:
[412-450]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
T
K
G
E
----
F
--
W
T
A
N
R
-------
V
G
T
G
G
D
P
N
N
---
R
S
V
F
E
W
A
H
D
K
G
L
V
C
Q
T
N
I
T
C
F
L
R
N
D
N
E
G
Q
D
Y
---------------
E
V
N
Q
T
L
R
E
R
Q
L
Y
T
K
N
D
S
L
T
G
T
D
F
G
M
T
D
D
G
P
S
D
A
Y
I
---
G
H
L
D
Y
G
G
G
V
E
C
D
A
L
F
P
D
W
G
R
P
D
V
A
E
W
W
G
N
N
Y
K
K
L
F
S
I
G
L
-----
D
F
V
W
Q
D
M
T
V
P
A
M
M
P
H
K
I
G
D
D
I
N
V
K
P
D
G
N
W
P
N
A
D
D
P
S
N
G
Q
Y
N
W
--
K
T
Y
H
P
Q
V
L
V
---
T
D
M
R
Y
E
N
H
---
G
R
E
P
M
V
T
Q
R
N
I
H
A
Y
T
L
C
E
S
T
R
K
E
G
I
V
E
N
A
D
T
L
T
K
F
R
R
S
Y
I
I
S
R
G
G
-
Y
I
G
N
Q
H
F
G
G
M
W
V
G
D
N
S
T
T
S
N
Y
I
Q
M
M
I
A
N
N
I
N
M
N
M
S
C
L
P
-
L
V
G
S
D
I
G
G
F
T
S
Y
D
N
E
N
Q
R
T
P
C
T
G
D
L
M
V
R
Y
V
Q
A
G
C
L
L
P
W
F
R
N
H
Y
D
R
W
I
E
S
K
D
H
G
K
D
Y
Q
E
L
Y
M
Y
P
N
E
M
D
T
L
R
K
F
V
E
F
R
Y
R
W
Q
E
V
L
Y
T
A
M
Y
Q
N
A
A
F
G
K
P
I
I
K
A
A
S
M
Y
N
N
D
S
N
V
R
R
A
Q
N
D
H
F
L
L
G
G
H
D
G
Y
R
I
L
C
A
P
V
V
W
E
N
S
T
E
R
E
L
Y
L
P
V
L
T
Q
W
Y
K
F
G
P
D
F
D
T
K
P
L
E
G
A
M
N
G
G
D
R
I
Y
N
Y
P
V
P
Q
S
E
S
P
I
F
V
R
E
G
A
I
L
P
T
R
Y
T
L
N
G
E
N
K
S
L
N
T
Y
T
D
E
D
P
L
V
F
E
V
F
P
L
G
N
N
R
A
D
G
M
C
Y
L
D
D
G
G
V
T
T
15
PsiBlast_CBE
36.67
38%
42
- C2 -
4AMW
1
?
B:
[412-450]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
T
K
G
E
----
F
--
W
T
A
N
R
-------
V
G
T
G
G
D
P
N
N
---
R
S
V
F
E
W
A
H
D
K
G
L
V
C
Q
T
N
I
T
C
F
L
R
N
D
N
E
G
Q
D
Y
---------------
E
V
N
Q
T
L
R
E
R
Q
L
Y
T
K
N
D
S
L
T
G
T
D
F
G
M
T
D
D
G
P
S
D
A
Y
I
---
G
H
L
D
Y
G
G
G
V
E
C
D
A
L
F
P
D
W
G
R
P
D
V
A
E
W
W
G
N
N
Y
K
K
L
F
S
I
G
L
-----
D
F
V
W
Q
D
M
T
V
P
A
M
M
P
H
K
I
G
D
D
I
N
V
K
P
D
G
N
W
P
N
A
D
D
P
S
N
G
Q
Y
N
W
--
K
T
Y
H
P
Q
V
L
V
---
T
D
M
R
Y
E
N
H
---
G
R
E
P
M
V
T
Q
R
N
I
H
A
Y
T
L
C
E
S
T
R
K
E
G
I
V
E
N
A
D
T
L
T
K
F
R
R
S
Y
I
I
S
R
G
G
-
Y
I
G
N
Q
H
F
G
G
M
W
V
G
D
N
S
T
T
S
N
Y
I
Q
M
M
I
A
N
N
I
N
M
N
M
S
C
L
P
-
L
V
G
S
D
I
G
G
F
T
S
Y
D
N
E
N
Q
R
T
P
C
T
G
D
L
M
V
R
Y
V
Q
A
G
C
L
L
P
W
F
R
N
H
Y
D
R
W
I
E
S
K
D
H
G
K
D
Y
Q
E
L
Y
M
Y
P
N
E
M
D
T
L
R
K
F
V
E
F
R
Y
R
W
Q
E
V
L
Y
T
A
M
Y
Q
N
A
A
F
G
K
P
I
I
K
A
A
S
M
Y
N
N
D
S
N
V
R
R
A
Q
N
D
H
F
L
L
G
G
H
D
G
Y
R
I
L
C
A
P
V
V
W
E
N
S
T
E
R
E
L
Y
L
P
V
L
T
Q
W
Y
K
F
G
P
D
F
D
T
K
P
L
E
G
A
M
N
G
G
D
R
I
Y
N
Y
P
V
P
Q
S
E
S
P
I
F
V
R
E
G
A
I
L
P
T
R
Y
T
L
N
G
E
N
K
S
L
N
T
Y
T
D
E
D
P
L
V
F
E
V
F
P
L
G
N
N
R
A
D
G
M
C
Y
L
D
D
G
G
V
T
T
8
PsiBlast_PDB
36.64
38%
35
- C2 -
4AMW
1
?
A:
[412-450]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
T
K
G
E
----
F
--
W
T
A
N
R
-------
V
G
T
G
G
D
P
N
N
---
R
S
V
F
E
W
A
H
D
K
G
L
V
C
Q
T
N
I
T
C
F
L
R
N
D
N
E
G
Q
D
Y
---------------
E
V
N
Q
T
L
R
E
R
Q
L
Y
T
K
N
D
S
L
T
G
T
D
F
G
M
T
D
D
G
P
S
D
A
Y
I
---
G
H
L
D
Y
G
G
G
V
E
C
D
A
L
F
P
D
W
G
R
P
D
V
A
E
W
W
G
N
N
Y
K
K
L
F
S
I
G
L
-----
D
F
V
W
Q
D
M
T
V
P
A
M
M
P
H
K
I
G
D
D
I
N
V
K
P
D
G
N
W
P
N
A
D
D
P
S
N
G
Q
Y
N
W
--
K
T
Y
H
P
Q
V
L
V
---
T
D
M
R
Y
E
N
H
---
G
R
E
P
M
V
T
Q
R
N
I
H
A
Y
T
L
C
E
S
T
R
K
E
G
I
V
E
N
A
D
T
L
T
K
F
R
R
S
Y
I
I
S
R
G
G
-
Y
I
G
N
Q
H
F
G
G
M
W
V
G
D
N
S
T
T
S
N
Y
I
Q
M
M
I
A
N
N
I
N
M
N
M
S
C
L
P
-
L
V
G
S
D
I
G
G
F
T
S
Y
D
N
E
N
Q
R
T
P
C
T
G
D
L
M
V
R
Y
V
Q
A
G
C
L
L
P
W
F
R
N
H
Y
D
R
W
I
E
S
K
D
H
G
K
D
Y
Q
E
L
Y
M
Y
P
N
E
M
D
T
L
R
K
F
V
E
F
R
Y
R
W
Q
E
V
L
Y
T
A
M
Y
Q
N
A
A
F
G
K
P
I
I
K
A
A
S
M
Y
N
N
D
S
N
V
R
R
A
Q
N
D
H
F
L
L
G
G
H
D
G
Y
R
I
L
C
A
P
V
V
W
E
N
S
T
E
R
E
L
Y
L
P
V
L
T
Q
W
Y
K
F
G
P
D
F
D
T
K
P
L
E
G
A
M
N
G
G
D
R
I
Y
N
Y
P
V
P
Q
S
E
S
P
I
F
V
R
E
G
A
I
L
P
T
R
Y
T
L
N
G
E
N
K
S
L
N
T
Y
T
D
E
D
P
L
V
F
E
V
F
P
L
G
N
N
R
A
D
G
M
C
Y
L
D
D
G
G
V
T
T
5
PsiBlast_PDB
36.56
38%
37
- C2 -
2X2H
1
?
A:
[412-450]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
T
K
G
E
----
F
--
W
T
A
N
R
-------
V
G
T
G
G
D
P
N
N
---
R
S
V
F
E
W
A
H
D
K
G
L
V
C
Q
T
N
I
T
C
F
L
R
N
D
N
E
G
Q
D
Y
---------------
E
V
N
Q
T
L
R
E
R
Q
L
Y
T
K
N
D
S
L
T
G
T
D
F
G
M
T
D
D
G
P
S
D
A
Y
I
---
G
H
L
D
Y
G
G
G
V
E
C
D
A
L
F
P
D
W
G
R
P
D
V
A
E
W
W
G
N
N
Y
K
K
L
F
S
I
G
L
-----
D
F
V
W
Q
D
M
T
V
P
A
M
M
P
H
K
I
G
D
D
I
N
V
K
P
D
G
N
W
P
N
A
D
D
P
S
N
G
Q
Y
N
W
--
K
T
Y
H
P
Q
V
L
V
---
T
D
M
R
Y
E
N
H
---
G
R
E
P
M
V
T
Q
R
N
I
H
A
Y
T
L
C
E
S
T
R
K
E
G
I
V
E
N
A
D
T
L
T
K
F
R
R
S
Y
I
I
S
R
G
G
-
Y
I
G
N
Q
H
F
G
G
M
W
V
G
D
N
S
T
T
S
N
Y
I
Q
M
M
I
A
N
N
I
N
M
N
M
S
C
L
P
-
L
V
G
S
D
I
G
G
F
T
S
Y
D
N
E
N
Q
R
T
P
C
T
G
D
L
M
V
R
Y
V
Q
A
G
C
L
L
P
W
F
R
N
H
Y
D
R
W
I
E
S
K
D
H
G
K
D
Y
Q
E
L
Y
M
Y
P
N
E
M
D
T
L
R
K
F
V
E
F
R
Y
R
W
Q
E
V
L
Y
T
A
M
Y
Q
N
A
A
F
G
K
P
I
I
K
A
A
S
M
Y
N
N
D
S
N
V
R
R
A
Q
N
D
H
F
L
L
G
G
H
D
G
Y
R
I
L
C
A
P
V
V
W
E
N
S
T
E
R
E
L
Y
L
P
V
L
T
Q
W
Y
K
F
G
P
D
F
D
T
K
P
L
E
G
A
M
N
G
G
D
R
I
Y
N
Y
P
V
P
Q
S
E
S
P
I
F
V
R
E
G
A
I
L
P
T
R
Y
T
L
N
G
E
N
K
S
L
N
T
Y
T
D
E
D
P
L
V
F
E
V
F
P
L
G
N
N
R
A
D
G
M
C
Y
L
D
D
G
G
V
T
T
17
PsiBlast_CBE
36.38
38%
40
* C2 *
2X2J
1
?
C:
[412-450]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
T
K
G
E
----
F
--
W
T
A
N
R
-------
V
G
T
G
G
D
P
N
N
---
R
S
V
F
E
W
A
H
D
K
G
L
V
C
Q
T
N
I
T
C
F
L
R
N
D
N
E
G
Q
D
Y
---------------
E
V
N
Q
T
L
R
E
R
Q
L
Y
T
K
N
D
S
L
T
G
T
D
F
G
M
T
D
D
G
P
S
D
A
Y
I
---
G
H
L
D
Y
G
G
G
V
E
C
D
A
L
F
P
D
W
G
R
P
D
V
A
E
W
W
G
N
N
Y
K
K
L
F
S
I
G
L
-----
D
F
V
W
Q
D
M
T
V
P
A
M
M
P
H
K
I
G
D
D
I
N
V
K
P
D
G
N
W
P
N
A
D
D
P
S
N
G
Q
Y
N
W
--
K
T
Y
H
P
Q
V
L
V
---
T
D
M
R
Y
E
N
H
---
G
R
E
P
M
V
T
Q
R
N
I
H
A
Y
T
L
C
E
S
T
R
K
E
G
I
V
E
N
A
D
T
L
T
K
F
R
R
S
Y
I
I
S
R
G
G
-
Y
I
G
N
Q
H
F
G
G
M
W
V
G
D
N
S
T
T
S
N
Y
I
Q
M
M
I
A
N
N
I
N
M
N
M
S
C
L
P
-
L
V
G
S
D
I
G
G
F
T
S
Y
D
N
E
N
Q
R
T
P
C
T
G
D
L
M
V
R
Y
V
Q
A
G
C
L
L
P
W
F
R
N
H
Y
D
R
W
I
E
S
K
D
H
G
K
D
Y
Q
E
L
Y
M
Y
P
N
E
M
D
T
L
R
K
F
V
E
F
R
Y
R
W
Q
E
V
L
Y
T
A
M
Y
Q
N
A
A
F
G
K
P
I
I
K
A
A
S
M
Y
N
N
D
S
N
V
R
R
A
Q
N
D
H
F
L
L
G
G
H
D
G
Y
R
I
L
C
A
P
V
V
W
E
N
S
T
E
R
E
L
Y
L
P
V
L
T
Q
W
Y
K
F
G
P
D
F
D
T
K
P
L
E
G
A
M
N
G
G
D
R
I
Y
N
Y
P
V
P
Q
S
E
S
P
I
F
V
R
E
G
A
I
L
P
T
R
Y
T
L
N
G
E
N
K
S
L
N
T
Y
T
D
E
D
P
L
V
F
E
V
F
P
L
G
N
N
R
A
D
G
M
C
Y
L
D
D
G
G
V
T
T
20
PsiBlast_CBE
36.36
38%
45
- C2 -
2X2I
1
?
C:
[412-450]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
T
K
G
E
----
F
--
W
T
A
N
R
-------
V
G
T
G
G
D
P
N
N
---
R
S
V
F
E
W
A
H
D
K
G
L
V
C
Q
T
N
I
T
C
F
L
R
N
D
N
E
G
Q
D
Y
---------------
E
V
N
Q
T
L
R
E
R
Q
L
Y
T
K
N
D
S
L
T
G
T
D
F
G
M
T
D
D
G
P
S
D
A
Y
I
---
G
H
L
D
Y
G
G
G
V
E
C
D
A
L
F
P
D
W
G
R
P
D
V
A
E
W
W
G
N
N
Y
K
K
L
F
S
I
G
L
-----
D
F
V
W
Q
D
M
T
V
P
A
M
M
P
H
K
I
G
D
D
I
N
V
K
P
D
G
N
W
P
N
A
D
D
P
S
N
G
Q
Y
N
W
--
K
T
Y
H
P
Q
V
L
V
---
T
D
M
R
Y
E
N
H
---
G
R
E
P
M
V
T
Q
R
N
I
H
A
Y
T
L
C
E
S
T
R
K
E
G
I
V
E
N
A
D
T
L
T
K
F
R
R
S
Y
I
I
S
R
G
G
-
Y
I
G
N
Q
H
F
G
G
M
W
V
G
D
N
S
T
T
S
N
Y
I
Q
M
M
I
A
N
N
I
N
M
N
M
S
C
L
P
-
L
V
G
S
D
I
G
G
F
T
S
Y
D
N
E
N
Q
R
T
P
C
T
G
D
L
M
V
R
Y
V
Q
A
G
C
L
L
P
W
F
R
N
H
Y
D
R
W
I
E
S
K
D
H
G
K
D
Y
Q
E
L
Y
M
Y
P
N
E
M
D
T
L
R
K
F
V
E
F
R
Y
R
W
Q
E
V
L
Y
T
A
M
Y
Q
N
A
A
F
G
K
P
I
I
K
A
A
S
M
Y
N
N
D
S
N
V
R
R
A
Q
N
D
H
F
L
L
G
G
H
D
G
Y
R
I
L
C
A
P
V
V
W
E
N
S
T
E
R
E
L
Y
L
P
V
L
T
Q
W
Y
K
F
G
P
D
F
D
T
K
P
L
E
G
A
M
N
G
G
D
R
I
Y
N
Y
P
V
P
Q
S
E
S
P
I
F
V
R
E
G
A
I
L
P
T
R
Y
T
L
N
G
E
N
K
S
L
N
T
Y
T
D
E
D
P
L
V
F
E
V
F
P
L
G
N
N
R
A
D
G
M
C
Y
L
D
D
G
G
V
T
T
11
PsiBlast_CBE
36.33
38%
43
- C2 -
4AMX
1
?
C:
[412-450]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
T
K
G
E
----
F
--
W
T
A
N
R
-------
V
G
T
G
G
D
P
N
N
---
R
S
V
F
E
W
A
H
D
K
G
L
V
C
Q
T
N
I
T
C
F
L
R
N
D
N
E
G
Q
D
Y
---------------
E
V
N
Q
T
L
R
E
R
Q
L
Y
T
K
N
D
S
L
T
G
T
D
F
G
M
T
D
D
G
P
S
D
A
Y
I
---
G
H
L
D
Y
G
G
G
V
E
C
D
A
L
F
P
D
W
G
R
P
D
V
A
E
W
W
G
N
N
Y
K
K
L
F
S
I
G
L
-----
D
F
V
W
Q
D
M
T
V
P
A
M
M
P
H
K
I
G
D
D
I
N
V
K
P
D
G
N
W
P
N
A
D
D
P
S
N
G
Q
Y
N
W
--
K
T
Y
H
P
Q
V
L
V
---
T
D
M
R
Y
E
N
H
---
G
R
E
P
M
V
T
Q
R
N
I
H
A
Y
T
L
C
E
S
T
R
K
E
G
I
V
E
N
A
D
T
L
T
K
F
R
R
S
Y
I
I
S
R
G
G
-
Y
I
G
N
Q
H
F
G
G
M
W
V
G
D
N
S
T
T
S
N
Y
I
Q
M
M
I
A
N
N
I
N
M
N
M
S
C
L
P
-
L
V
G
S
D
I
G
G
F
T
S
Y
D
N
E
N
Q
R
T
P
C
T
G
D
L
M
V
R
Y
V
Q
A
G
C
L
L
P
W
F
R
N
H
Y
D
R
W
I
E
S
K
D
H
G
K
D
Y
Q
E
L
Y
M
Y
P
N
E
M
D
T
L
R
K
F
V
E
F
R
Y
R
W
Q
E
V
L
Y
T
A
M
Y
Q
N
A
A
F
G
K
P
I
I
K
A
A
S
M
Y
N
N
D
S
N
V
R
R
A
Q
N
D
H
F
L
L
G
G
H
D
G
Y
R
I
L
C
A
P
V
V
W
E
N
S
T
E
R
E
L
Y
L
P
V
L
T
Q
W
Y
K
F
G
P
D
F
D
T
K
P
L
E
G
A
M
N
G
G
D
R
I
Y
N
Y
P
V
P
Q
S
E
S
P
I
F
V
R
E
G
A
I
L
P
T
R
Y
T
L
N
G
E
N
K
S
L
N
T
Y
T
D
E
D
P
L
V
F
E
V
F
P
L
G
N
N
R
A
D
G
M
C
Y
L
D
D
G
G
V
T
T
19
PsiBlast_CBE
36.25
38%
35
- C2 -
2X2I
1
?
D:
[412-450]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
T
K
G
E
----
F
--
W
T
A
N
R
-------
V
G
T
G
G
D
P
N
N
---
R
S
V
F
E
W
A
H
D
K
G
L
V
C
Q
T
N
I
T
C
F
L
R
N
D
N
E
G
Q
D
Y
---------------
E
V
N
Q
T
L
R
E
R
Q
L
Y
T
K
N
D
S
L
T
G
T
D
F
G
M
T
D
D
G
P
S
D
A
Y
I
---
G
H
L
D
Y
G
G
G
V
E
C
D
A
L
F
P
D
W
G
R
P
D
V
A
E
W
W
G
N
N
Y
K
K
L
F
S
I
G
L
-----
D
F
V
W
Q
D
M
T
V
P
A
M
M
P
H
K
I
G
D
D
I
N
V
K
P
D
G
N
W
P
N
A
D
D
P
S
N
G
Q
Y
N
W
--
K
T
Y
H
P
Q
V
L
V
---
T
D
M
R
Y
E
N
H
---
G
R
E
P
M
V
T
Q
R
N
I
H
A
Y
T
L
C
E
S
T
R
K
E
G
I
V
E
N
A
D
T
L
T
K
F
R
R
S
Y
I
I
S
R
G
G
-
Y
I
G
N
Q
H
F
G
G
M
W
V
G
D
N
S
T
T
S
N
Y
I
Q
M
M
I
A
N
N
I
N
M
N
M
S
C
L
P
-
L
V
G
S
D
I
G
G
F
T
S
Y
D
N
E
N
Q
R
T
P
C
T
G
D
L
M
V
R
Y
V
Q
A
G
C
L
L
P
W
F
R
N
H
Y
D
R
W
I
E
S
K
D
H
G
K
D
Y
Q
E
L
Y
M
Y
P
N
E
M
D
T
L
R
K
F
V
E
F
R
Y
R
W
Q
E
V
L
Y
T
A
M
Y
Q
N
A
A
F
G
K
P
I
I
K
A
A
S
M
Y
N
N
D
S
N
V
R
R
A
Q
N
D
H
F
L
L
G
G
H
D
G
Y
R
I
L
C
A
P
V
V
W
E
N
S
T
E
R
E
L
Y
L
P
V
L
T
Q
W
Y
K
F
G
P
D
F
D
T
K
P
L
E
G
A
M
N
G
G
D
R
I
Y
N
Y
P
V
P
Q
S
E
S
P
I
F
V
R
E
G
A
I
L
P
T
R
Y
T
L
N
G
E
N
K
S
L
N
T
Y
T
D
E
D
P
L
V
F
E
V
F
P
L
G
N
N
R
A
D
G
M
C
Y
L
D
D
G
G
V
T
T