@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : jhp_1200: (2015-12-21 )
MPSVLENILKDKLLEVAVLKKNHALPINIAPSDRDFKKALLEKKTSFILEYKKASPSKGLIRKDFDLLEITKTYEKFASCVSVLADSKYFLGSYENIKIVSQHSTKPILCKDFIIDAFQIKLARVMGSNAVLLMLSVLDDKNYLELFNLAKSLNMSVLTEVSNQQEIERLLKLQYDIIGINNRDLHTLKTDIFHTLELRPLLPKDAIIISESGIYSHAQIKALAPCVNGFLVGSSLMKEKDLKKACIKLILGENKVCGLTRIKDAKAVYKNHFIYGGLIFEKSSPRYIKPKEALKITKAVKKLDFVGVFVKDKIKKIAKIAKKLDLKAVQLYGYSQKEIAQLKKSLPKTCAIWQVVSVADSKDLAPKTKEASLILYDTKGDKMGGNGVSFDWEILENAKTPFMLAGGLNLDNIQKALKIKALGLDFNSGLEISPGIKNKDKIKQLARILREY
Atome Classification :
(23 SA)
.........10..---......20---.....---.----..30...--.....40-.----....----...50........60........70...-...-..80........90........100....-...110.......120.-......130.......140.........150.......160-.......170-.......180.......190.......200.---.-------.....210.......220..-..-..--.230.......240.......250........260.......270.......280.......290.......300.......310.......320.......330...-..-..340.......350.......360.......370.......380.......390......-.-400.......410.......420.......430.......440.......450
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
M
P
S
V
L
E
N
I
L
K
D
K
L
---
L
E
V
A
VLKK---NH
A
L
P
---
I
----NIAPS
D
R
--
D
F
K
K
A
L
L
-
E
----
K
K
T
S
----
F
I
L
E
YKKASPSKG
L
I
R
KD
F
D
L
L
E
I
T
K
T
Y
-
E
K
F
-
A
S
C
V
S
V
L
ADS
K
Y
F
LGSYE
N
I
K
I
V
SQHSTK-
P
I
L
C
K
D
F
I
I
D
A
F
Q
I
K
L
A
-
R
V
MGSN
A
V
L
L
M
L
SVLDD--
K
N
Y
L
E
L
F
N
L
A
K
S
L
N
M
S
V
L
T
EVS-
N
Q
Q
E
I
E
R
L
L
K
-
L
Q
Y
D
I
I
GINNR
D
L
H
T
L
K
T
D
I
F
H
T
LELRPLLP---K-------
D
A
I
I
I
SESGIYS
H
A
Q
I
K
A
L
A
-
P
C
-
V
N
--
G
F
L
V
G
S
S
L
M
K
E
K
D
L
K
K
A
C
I
K
L
I
L-GENKVCGLTRI
K
D
A
K
A
V
Y
KN
H
F
I
Y
G
G
L
I
F
EKSSPRYI
K
P
K
E
A
L
K
I
T
K
A
V
K
K
L
D
F
V
G
V
F
V
K
D
K
I
K
K
I
A
K
I
A
K
KLD
L
K
A
V
Q
L
YGY
S
-
Q
K
-
E
I
A
Q
L
K
K
SLP
K
T
C
A
I
W
Q
V
V
SVADSKDLAPKTKE
A
S
L
I
L
Y
DTKGDKMGGNGV
S
F
D
W
E
I
L
ENA-K-T
P
F
M
L
AGGL
N
L
D
N
I
Q
K
A
L
K
I
K
A
L
GLDFNSGLEISPGIK
N
K
D
K
I
K
Q
L
A
R
I
L
REY
32
HHSearch
96.13
47%
-108
- C6 -
1PII
2
TRPC_ECOLI
A:
[1-452]
M
Q
T
V
L
A
K
I
V
A
D
K
A
---
I
W
V
E
A
R
K
Q
---
Q
Q
P
L
A
SFQ
N
----
E
V
Q
P
S
T
R
--
H
F
Y
D
A
L
Q
-
G
----
A
R
T
A
----
F
I
L
E
C
K
K
A
S
P
S
K
G
V
I
R
D
D
F
D
P
A
R
I
A
A
I
Y
-
K
H
Y
-
A
S
A
I
S
V
L
T
D
E
K
Y
F
Q
G
S
F
N
F
L
P
I
V
S
Q
I
A
P
Q
-
P
I
L
C
K
D
F
I
I
D
P
Y
Q
I
Y
L
A
-
R
Y
Y
Q
A
D
A
C
L
L
M
L
S
V
L
D
D
--
D
Q
Y
R
Q
L
A
A
V
A
H
S
L
E
M
G
V
L
T
E
V
S
-
N
E
E
E
Q
E
R
A
I
A
-
L
G
A
K
V
V
G
I
N
N
R
D
L
R
D
L
S
I
D
L
N
R
T
R
E
L
A
P
K
L
G
---
H
-------
N
V
T
V
I
S
E
S
G
I
N
T
Y
A
Q
V
R
E
L
S
-
H
F
-
A
N
--
G
F
L
I
G
S
A
L
M
A
H
D
D
L
H
A
A
V
R
R
V
L
L
-
G
E
N
K
V
C
G
L
T
R
G
Q
D
A
K
A
A
Y
D
A
G
A
I
Y
G
G
L
I
F
V
A
T
S
P
R
C
V
N
V
E
Q
A
Q
E
V
M
A
A
A
-
P
L
Q
Y
V
G
V
F
R
N
H
D
I
A
D
V
V
D
K
A
K
V
L
S
L
A
A
V
Q
L
H
G
N
E
E
Q
L
-
Y
I
D
T
L
R
E
A
L
P
A
H
V
A
I
W
K
A
L
S
V
G
E
T
L
P
A
R
E
F
Q
H
V
D
K
Y
V
L
D
N
G
----
Q
G
G
S
G
Q
R
F
D
W
S
L
L
N
G
Q
S
L
-
G
N
V
L
L
A
G
G
L
G
A
D
N
C
V
E
A
A
Q
T
G
C
A
G
L
D
F
N
S
A
V
E
S
Q
P
G
I
K
D
A
R
L
L
A
S
V
F
Q
T
L
R
A
Y
1
PsiBlast_PDB
94.75
45%
-103
- C6 -
1PII
2
TRPC_ECOLI
A:
[1-452]
M
Q
T
V
L
A
K
I
V
A
D
K
A
---
I
W
V
E
A
R
K
Q
---
Q
Q
P
L
A
---
S
FQN-
E
V
Q
P
S
T
R
--
H
F
Y
D
A
L
Q
-
G
----
A
R
T
A
----
F
I
L
E
C
K
K
A
S
P
S
K
G
V
I
R
D
D
F
D
P
A
R
I
A
A
I
Y
-
K
H
Y
-
A
S
A
I
S
V
L
T
D
E
K
Y
F
Q
G
S
F
N
F
L
P
I
V
S
Q
I
A
P
Q
-
P
I
L
C
K
D
F
I
I
D
P
Y
Q
I
Y
L
A
-
R
Y
Y
Q
A
D
A
C
L
L
M
L
S
V
L
D
D
--
D
Q
Y
R
Q
L
A
A
V
A
H
S
L
E
M
G
V
L
T
E
V
S
-
N
E
E
E
Q
E
R
A
I
A
-
L
G
A
K
V
V
G
I
N
N
R
D
L
R
D
L
S
I
D
L
N
R
T
R
E
L
A
P
K
L
G
---
H
-------
N
V
T
V
I
S
E
S
G
I
N
T
Y
A
Q
V
R
E
L
S
-
H
F
-
A
N
--
G
F
L
I
G
S
A
L
M
A
H
D
D
L
H
A
A
V
R
R
V
L
L
-
G
E
N
K
V
C
G
L
T
R
G
Q
D
A
K
A
A
Y
D
A
G
A
I
Y
G
G
L
I
F
V
A
T
S
P
R
C
V
N
V
E
Q
A
Q
E
V
M
-
A
A
A
P
L
Q
Y
V
G
V
F
R
N
H
D
I
A
D
V
V
D
K
A
K
V
L
S
L
A
A
V
Q
L
H
G
N
E
-
E
Q
L
Y
I
D
T
L
R
E
A
L
P
A
H
V
A
I
W
K
A
L
S
V
G
E
T
L
----
P
A
R
E
F
Q
H
V
D
K
Y
V
L
D
N
G
Q
G
G
S
G
Q
R
F
D
W
S
L
L
N
G
Q
-
S
L
G
N
V
L
L
A
G
G
L
G
A
D
N
C
V
E
A
A
Q
T
G
C
A
G
L
D
F
N
S
A
V
E
S
Q
P
G
I
K
D
A
R
L
L
A
S
V
F
Q
T
L
R
A
Y
2
PsiBlast_PDB
75.88
50%
-115
- C6 -
1JCM
6
TRPC_ECOLI
P:
[1-259]
M
Q
C
V
L
A
K
I
V
A
D
K
A
---
I
W
V
E
A
R
K
Q
---
Q
Q
P
L
A
---
S
FQN-
E
V
Q
P
S
T
R
--
H
F
Y
D
A
L
Q
-
G
----
A
R
T
A
----
F
I
L
E
C
K
K
A
S
P
S
K
G
V
I
R
D
D
F
D
P
A
R
I
A
A
I
Y
-
K
H
Y
-
A
S
A
I
S
V
L
T
D
E
K
Y
F
Q
G
S
F
N
F
L
P
I
V
S
Q
I
A
P
Q
-
P
I
L
C
K
D
F
I
I
D
P
Y
Q
I
Y
L
A
-
R
Y
Y
Q
A
D
A
C
L
L
M
L
S
V
L
D
D
--
D
Q
Y
R
Q
L
A
A
V
A
H
S
L
E
M
G
V
L
T
E
V
S
-
N
E
E
E
Q
E
R
A
I
A
-
L
G
A
K
V
V
G
I
N
N
R
D
L
C
D
L
S
I
D
L
N
R
T
R
E
L
A
P
K
L
G
---
H
-------
N
V
T
V
I
S
E
S
G
I
N
T
Y
A
Q
V
R
E
L
S
-
H
F
-
A
N
--
G
F
L
I
G
S
A
L
M
A
H
D
D
L
H
A
A
V
R
R
V
L
L
-
G
E
N
K
V
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
54
Fugue
72.37
50%
-125
- C6 -
1PII
1
?
?:
[1-255]
M
Q
T
V
L
A
K
I
V
A
D
K
A
---
I
W
V
E
A
R
K
Q
Q
QP
L
A
S
F
Q
---
N
----
E
V
Q
P
S
T
R
--
H
F
Y
D
A
L
Q
-
G
----
A
R
T
A
----
F
I
L
E
C
K
K
A
S
P
S
K
G
V
I
R
D
D
F
D
P
A
R
I
A
A
I
Y
-
K
H
-Y
A
S
A
I
S
V
L
T
D
E
K
Y
F
Q
G
S
F
N
F
L
P
I
V
S
Q
I
A
P
-
Q
P
I
L
C
K
D
F
I
I
D
P
Y
Q
I
Y
L
A
R
-
Y
Y
Q
A
D
A
C
L
L
M
L
S
V
L
D
D
--
D
Q
Y
R
Q
L
A
A
V
A
H
S
L
E
M
G
V
L
T
E
V
S
N-
E
E
E
Q
E
R
A
I
A
-
L
G
A
K
V
V
G
I
N
N
R
D
L
R
D
L
S
I
D
L
N
R
T
R
E
L
A
P
K
L
G
---
H
-------
N
V
T
V
I
S
E
S
G
I
N
T
Y
A
Q
V
R
E
L
S
-
H
---
F
AN
G
F
L
I
G
S
A
L
M
A
H
D
D
L
H
A
A
V
R
R
V
L
L
-
G
E
N
K
V
C
G
L
T
R
G
Q
D
A
K
A
A
Y
D
A
G
A
I
Y
G
G
L
I
F
V
A
T
S
P
R
C
V
N
V
E
Q
A
Q
E
V
M
A
A
A
P
L
Q
Y
V
G
V
F
R
N
H
D
I
A
D
V
V
D
K
A
K
V
L
S
L
A
A
V
Q
L
H
G
N
E
E
-
Q
L
-
Y
I
D
T
L
R
E
A
L
P
A
H
V
A
I
W
K
A
L
S
V
G
E
T
L
P
A
R
E
F
Q
H
V
D
K
Y
V
L
D
N
G
Q
G
G
S
G
Q
R
F
D
W
S
L
L
N
G
Q
S
L
G
N
-
V
-
L
L
A
G
G
L
G
A
D
N
C
V
E
A
A
Q
T
G
C
A
G
L
D
F
N
S
A
V
E
S
Q
P
G
I
K
D
A
R
L
L
A
S
V
F
Q
T
L
R
A
Y
---
3
PsiBlast_PDB
69.20
37%
-115
- C6 -
3TSM
1
TRPC_BRUA2
A:
[44-268]
----------------------------------------------
R
--
G
F
L
K
A
L
E
-
A
----
K
R
A
A
G
Q
F
A
L
I
A
E
I
K
K
A
S
P
S
K
G
L
I
R
P
D
F
D
P
P
A
L
A
K
A
Y
-
E
E
G
G
A
A
C
L
S
V
L
T
D
T
P
S
F
Q
G
A
P
E
F
L
T
A
A
R
Q
A
C
S
L
-
P
A
L
R
K
D
F
L
F
D
P
Y
Q
V
Y
E
A
-
R
S
W
G
A
D
C
I
L
I
I
M
A
S
V
D
D
--
D
L
A
K
E
L
E
D
T
A
F
A
L
G
M
D
A
L
I
E
V
H
-
D
E
A
E
M
E
R
A
L
K
-
L
S
S
R
L
L
G
V
N
N
R
N
L
R
S
F
E
V
N
L
A
V
S
E
R
L
A
K
M
A
P
---
S
-------
D
R
L
L
V
G
E
S
G
I
F
T
H
E
D
C
L
R
L
E
-
K
S
G
I
G
--
T
F
L
I
G
E
S
L
M
R
Q
H
D
V
A
A
A
T
R
A
L
L
T
-
G
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
35
HHSearch
69.16
37%
-111
- C6 -
3TSM
3
TRPC_BRUA2
A:
[8-268]
--
D
I
L
R
K
I
E
A
Y
K
R
---
E
E
I
A
A
A
K
A
---
R
L
A
L
D
E
--
L
K
A
R
T
R
D
Q
S
A
P
R
--
G
F
L
K
A
L
E
-
A
K
R
A
A
G
Q
F
A
----
L
I
A
E
I
K
K
A
S
P
S
K
G
L
I
R
P
D
F
D
P
P
A
L
A
K
A
Y
E
E
G
G
-
A
A
C
L
S
V
L
T
D
T
P
S
F
Q
G
A
P
E
F
L
T
A
A
R
Q
A
C
S
L
-
P
A
L
R
K
D
F
L
F
D
P
Y
Q
V
Y
E
A
-
R
S
W
G
A
D
C
I
L
I
I
M
A
S
V
D
D
--
D
L
A
K
E
L
E
D
T
A
F
A
L
G
M
D
A
L
I
E
V
H
-
D
E
A
E
M
E
R
A
L
K
-
L
S
S
R
L
L
G
V
N
N
R
N
L
R
S
F
E
V
N
L
A
V
S
E
R
L
A
K
M
A
P
---
S
-------
D
R
L
L
V
G
E
S
G
I
F
T
H
E
D
C
L
R
L
E
K
S
G
-
I
G
--
T
F
L
I
G
E
S
L
M
R
Q
H
D
V
A
A
A
T
R
A
L
L
T
-
G
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
38
HHSearch
69.12
33%
-112
* C6 *
3QJA
1
TRPC_MYCTU
A:
[4-260]
-
A
T
V
L
D
S
I
L
E
G
V
R
---
A
D
V
A
A
R
E
A
---
S
V
S
L
S
E
--
I
K
A
A
A
A
A
A
P
P
P
L
--
D
V
M
A
A
L
R
-
E
----
P
G
I
G
----
V
I
A
E
V
K
-------------
D
P
A
K
L
A
Q
A
Y
Q
D
G
G
-
A
R
I
V
S
V
V
T
E
Q
R
R
F
Q
G
S
L
D
D
L
D
A
V
R
A
S
V
S
I
-
P
V
L
R
K
D
F
V
V
Q
P
Y
Q
I
H
E
A
-
R
A
H
G
A
D
M
L
L
L
I
V
A
A
L
E
Q
--
S
V
L
V
S
M
L
D
R
T
E
S
L
G
M
T
A
L
V
E
V
H
-
T
E
Q
E
A
D
R
A
L
K
-
A
G
A
K
V
I
G
V
N
A
R
D
L
M
T
L
D
V
D
R
D
C
F
A
R
I
A
P
G
L
P
---
S
-------
S
V
I
R
I
A
E
S
G
V
R
G
T
A
D
L
L
A
Y
A
G
A
G
-
A
D
--
A
V
L
V
G
E
G
L
V
T
S
G
D
P
R
A
A
V
A
D
L
V
T
-
A
G
T
H
P
S
C
P
K
P
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
6
PsiBlast_PDB
68.26
35%
-101
- C6 -
1VC4
6
?
A:
[8-253]
V
P
G
V
L
G
E
I
A
R
K
R
A
---
S
E
V
A
---------
P
Y
P
---
L
----
P
E
P
P
S
V
P
--
S
F
K
E
A
L
L
-
R
----
P
G
L
S
----
V
I
A
E
V
K
R
Q
S
P
S
E
G
L
I
R
-
E
V
D
P
V
E
A
A
L
A
Y
-
A
R
G
G
A
R
A
V
S
V
L
T
E
P
H
R
F
G
G
S
L
L
D
L
K
R
V
R
E
A
V
D
L
-
P
L
L
R
K
D
F
V
V
D
P
F
M
L
E
E
A
-
R
A
F
G
A
S
A
A
L
L
I
V
A
L
L
G
E
L
T
G
A
Y
L
E
---
E
A
R
R
L
G
L
E
A
L
V
E
V
H
-
T
E
R
E
L
E
I
A
L
E
-
A
G
A
E
V
L
G
I
N
N
R
D
L
A
T
L
H
I
N
----
L
E
T
A
P
R
L
G
---
R
L
A
R
K
R
GF
G
G
V
L
V
A
E
S
G
Y
S
R
K
E
E
L
K
A
L
E
-
G
L
-
F
D
--
A
V
L
I
G
T
S
L
M
R
A
P
D
L
E
A
A
L
R
E
L
V
G
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
23
PsiBlast_CBE
67.85
35%
-102
- C6 -
1VC4
8
?
B:
[8-253]
V
P
G
V
L
G
E
I
A
R
K
R
A
---
S
E
V
A
---------
P
Y
P
---
L
----
P
E
P
P
S
V
P
--
S
F
K
E
A
L
L
-
R
----
P
G
L
S
----
V
I
A
E
V
K
R
Q
S
P
S
E
G
L
I
R
-
E
V
D
P
V
E
A
A
L
A
Y
-
A
R
G
G
A
R
A
V
S
V
L
T
E
P
H
R
F
G
G
S
L
L
D
L
K
R
V
R
E
A
V
D
L
-
P
L
L
R
K
D
F
V
V
D
P
F
M
L
E
E
A
-
R
A
F
G
A
S
A
A
L
L
I
V
A
L
L
G
E
LT
G
A
Y
L
E
---
E
A
R
R
L
G
L
E
A
L
V
E
V
H
-
T
E
R
E
L
E
I
A
L
E
-
A
G
A
E
V
L
G
I
N
N
R
D
L
A
T
L
H
I
N
----
L
E
T
A
P
R
L
G
---
R
LARKRGF
G
G
V
L
V
A
E
S
G
Y
S
R
K
E
E
L
K
A
L
E
-
G
L
-
F
D
--
A
V
L
I
G
T
S
L
M
R
A
P
D
L
E
A
A
L
R
E
L
V
G
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
37
HHSearch
67.69
36%
-107
- C6 -
1VC4
6
?
A:
[8-252]
V
P
G
V
L
G
E
I
A
R
K
R
A
---
S
E
V
A
P
Y
-------
P
L
---------
P
E
P
P
S
V
P
--
S
F
K
E
A
L
L
-
R
----
P
G
L
S
----
V
I
A
E
V
K
R
Q
S
P
S
E
G
L
I
R
E
-
V
D
P
V
E
A
A
L
A
Y
A
R
G
G
-
A
R
A
V
S
V
L
T
E
P
H
R
F
G
G
S
L
L
D
L
K
R
V
R
E
A
V
D
L
-
P
L
L
R
K
D
F
V
V
D
P
F
M
L
E
E
A
-
R
A
F
G
A
S
A
A
L
L
I
V
A
L
L
G
---
E
L
T
G
A
Y
L
E
E
A
R
R
L
G
L
E
A
L
V
E
V
H
-
T
E
R
E
L
E
I
A
L
E
-
A
G
A
E
V
L
G
I
N
N
R
D
L
A
T
L
H
I
N
L
E
T
A
P
R
L
G
R
L
A
R
K
R
G
F
-------
G
G
V
L
V
A
E
S
G
Y
S
R
K
E
E
L
K
A
L
E
-
G
L
-
F
D
--
A
V
L
I
G
T
S
L
M
R
A
P
D
L
E
A
A
L
R
E
L
V
G
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
36
HHSearch
66.82
32%
-108
- C6 -
1I4N
1
TRPC_THEMA
A:
[1-248]
--
R
R
L
W
E
I
V
E
A
K
K
---
K
D
I
L
E
I
D
G
---
E
-
N
L
I
---------
V
Q
R
R
N
H
--
R
F
L
E
V
L
S
G
K
----
E
R
V
K
----
I
I
A
E
F
K
K
A
S
P
S
A
G
D
I
N
A
D
A
S
L
E
D
F
I
R
M
Y
D
E
-
L
-
A
D
A
I
S
I
L
T
E
K
H
Y
F
K
G
D
P
A
F
V
R
A
A
R
N
L
T
C
R
-
P
I
L
A
K
D
F
Y
I
D
T
V
Q
V
K
L
A
-
S
S
V
G
A
D
A
I
L
I
I
A
R
I
L
T
A
--
E
Q
I
K
E
I
Y
E
A
A
E
E
L
G
M
D
S
L
V
E
V
H
-
S
R
E
D
L
E
K
V
F
S
V
I
R
P
K
I
I
G
I
N
T
R
D
L
D
T
F
E
I
K
K
N
V
L
W
E
L
L
P
L
V
P
---
D
-------
D
T
V
V
V
A
E
S
G
I
K
D
P
R
E
L
K
D
L
R
-
G
K
-
V
N
--
A
V
L
V
G
T
S
I
M
K
A
E
N
P
R
R
F
L
E
E
M
R
A
-
W
S
E
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
21
PsiBlast_CBE
66.71
37%
-105
- C6 -
3TSM
4
TRPC_BRUA2
B:
[44-268]
----------------------------------------------
R
--
G
F
L
K
A
L
E
-
A
----
K
R
A
A
G
Q
F
A
L
I
A
E
I
K
K
A
S
P
S
K
G
L
I
R
P
D
F
D
P
P
A
L
A
K
A
Y
-
E
E
G
G
A
A
C
L
S
V
L
T
D
T
P
S
F
Q
G
A
P
E
F
L
T
A
A
R
Q
A
C
S
L
-
P
A
L
R
K
D
F
L
F
D
P
Y
Q
V
Y
E
A
-
R
S
W
G
A
D
C
I
L
I
I
M
A
S
V
D
D
--
D
L
A
K
E
L
E
D
T
A
F
A
L
G
M
D
A
L
I
E
V
H
-
D
E
A
E
M
E
R
A
L
K
-
L
S
S
R
L
L
G
V
N
N
R
N
L
R
S
F
E
V
N
L
A
V
S
E
R
L
A
K
M
A
P
---
S
-------
D
R
L
L
V
G
E
S
G
I
F
T
H
E
D
C
L
R
L
E
-
K
S
G
I
G
--
T
F
L
I
G
E
S
L
M
R
Q
H
D
V
A
A
A
T
R
A
L
L
T
-
G
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
13
PsiBlast_PDB
65.37
33%
-106
- C6 -
3T40
3
TRPC_MYCTU
A:
[42-267]
-------------------------------------------------
D
V
M
A
A
L
R
-
E
----
P
G
I
G
----
V
I
A
E
V
K
R
---------
T
I
A
D
P
A
K
L
A
Q
A
Y
-
Q
D
G
G
A
R
I
V
S
V
V
T
E
Q
R
R
F
Q
G
S
L
D
D
L
D
A
V
R
A
S
V
S
I
-
P
V
L
R
K
D
F
V
V
Q
P
Y
Q
I
H
E
A
-
R
A
H
G
A
D
M
L
L
L
I
V
A
A
L
E
Q
--
S
V
L
V
S
M
L
D
R
T
E
S
L
G
M
T
A
L
V
E
V
H
-
T
E
Q
E
A
D
R
A
L
K
-
A
G
A
K
V
I
G
V
N
A
R
-----
D
V
D
R
D
C
F
A
R
I
A
P
G
L
P
---
S
-------
S
V
I
R
I
A
E
S
G
V
R
G
T
A
D
L
L
A
Y
A
-
G
A
G
A
D
--
A
V
L
V
G
E
G
L
V
T
S
G
D
P
R
A
A
V
A
D
L
V
T
A
G
T
H
P
S
C
P
K
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
16
PsiBlast_PDB
64.36
33%
-100
- C6 -
3T78
5
TRPC_MYCTU
A:
[42-263]
-------------------------------------------------
D
V
M
A
A
L
R
-
E
----
P
G
I
G
----
V
I
A
E
V
K
R
A
S
P
S
A
G
A
L
A
T
I
A
D
P
A
K
L
A
Q
A
Y
-
Q
D
G
G
A
R
I
V
S
V
V
T
E
Q
R
R
F
Q
G
S
L
D
D
L
D
A
V
R
A
S
V
S
I
-
P
V
L
R
K
D
F
V
V
Q
P
Y
Q
I
H
E
A
-
R
A
H
G
A
D
M
L
L
L
I
V
A
A
L
E
Q
--
S
V
L
V
S
M
L
D
R
T
E
S
L
G
M
T
A
L
V
E
V
H
-
T
E
Q
E
A
D
R
A
L
K
-
A
G
A
K
V
I
G
V
N
A
R
D
L
M
T
L
--
D
R
D
C
F
A
R
I
A
P
G
L
P
---
S
-------
S
V
I
R
I
A
E
S
G
V
R
G
T
A
D
L
L
A
Y
A
-
G
A
G
A
D
--
A
V
L
V
G
E
G
L
V
T
S
G
D
P
R
A
A
V
A
D
L
V
T
A
G
T
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
18
PsiBlast_PDB
64.17
32%
-99
- C6 -
4FB7
1
TRPC_MYCTU
A:
[45-270]
-------------------------------------------------
D
V
M
A
A
L
R
-
E
----
P
G
I
G
----
V
I
A
E
V
K
R
A
S
P
S
A
G
A
L
A
T
I
A
D
P
A
K
L
A
Q
A
Y
-
Q
D
G
G
A
R
I
V
S
V
V
T
E
Q
R
R
F
Q
G
S
L
D
D
L
D
A
V
R
A
S
V
S
I
-
P
V
L
R
K
D
F
V
V
Q
P
Y
Q
I
H
E
A
-
R
A
H
G
A
D
M
L
L
L
I
V
A
A
L
E
Q
--
S
V
L
V
S
M
L
D
R
T
E
S
L
G
M
T
A
L
V
E
V
H
-
T
E
Q
E
A
D
R
A
L
K
-
A
G
A
K
V
I
G
V
N
A
R
D
L
M
T
L
D
V
D
R
D
C
F
A
R
I
A
P
G
L
P
---
S
-------
S
V
I
R
I
A
E
S
G
V
R
G
T
A
D
L
L
A
Y
A
-
G
A
G
A
D
--
A
V
L
V
G
E
G
L
V
T
S
G
D
P
R
A
A
V
A
D
L
V
T
A
G
T
H
P
S
C
P
K
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
15
PsiBlast_PDB
63.85
33%
-100
- C6 -
3T55
3
TRPC_MYCTU
A:
[42-262]
-------------------------------------------------
D
V
M
A
A
L
R
-
E
----
P
G
I
G
----
V
I
A
E
V
K
R
A
S
P
S
A
G
A
L
A
T
I
A
D
P
A
K
L
A
Q
A
Y
-
Q
D
G
G
A
R
I
V
S
V
V
T
E
Q
R
R
F
Q
G
S
L
D
D
L
D
A
V
R
A
S
V
S
I
-
P
V
L
R
K
D
F
V
V
Q
P
Y
Q
I
H
E
A
-
R
A
H
G
A
D
M
L
L
L
I
V
A
A
L
E
Q
--
S
V
L
V
S
M
L
D
R
T
E
S
L
G
M
T
A
L
V
E
V
H
-
T
E
Q
E
A
D
R
A
L
K
-
A
G
A
K
V
I
G
V
N
A
R
D
L
M
T
L
D
V
D
R
D
C
F
A
R
I
A
P
G
L
P
---
S
-------
S
V
I
R
I
A
E
S
G
V
R
G
T
A
D
L
L
A
Y
A
-
G
A
G
A
D
--
A
V
L
V
G
E
G
L
V
T
S
G
D
P
R
A
A
V
A
D
L
V
T
A
G
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
14
PsiBlast_PDB
63.73
33%
-98
- C6 -
3T44
2
TRPC_MYCTU
A:
[42-263]
-------------------------------------------------
D
V
M
A
A
L
R
-
E
----
P
G
I
G
----
V
I
A
E
V
K
R
A
S
P
S
A
G
A
L
A
T
I
A
D
P
A
K
L
A
Q
A
Y
-
Q
D
G
G
A
R
I
V
S
V
V
T
E
Q
R
R
F
Q
G
S
L
D
D
L
D
A
V
R
A
S
V
S
I
-
P
V
L
R
K
D
F
V
V
Q
P
Y
Q
I
H
E
A
-
R
A
H
G
A
D
M
L
L
L
I
V
A
A
L
E
Q
--
S
V
L
V
S
M
L
D
R
T
E
S
L
G
M
T
A
L
V
E
V
H
-
T
E
Q
E
A
D
R
A
L
K
-
A
G
A
K
V
I
G
V
N
A
R
D
L
M
T
L
D
V
D
R
D
C
F
A
R
I
A
P
G
L
P
---
S
-------
S
V
I
R
I
A
E
S
G
V
R
G
T
A
D
L
L
A
Y
A
-
G
A
G
A
D
--
A
V
L
V
G
E
G
L
V
T
S
G
D
P
R
A
A
V
A
D
L
V
T
A
G
T
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
12
PsiBlast_PDB
63.68
35%
-109
- C6 -
1A53
1
TRPC_SULSO
A:
[45-237]
----------------------------------------------------------------
T
A
----
I
I
A
E
Y
K
R
K
S
P
S
G
L
D
V
E
R
D
--
P
I
E
Y
S
K
F
M
-
E
R
Y
-
A
V
G
L
S
I
L
T
E
E
K
Y
F
N
G
S
Y
E
T
L
R
K
I
A
S
S
V
S
I
-
P
I
L
M
K
D
F
I
V
K
E
S
Q
I
D
D
A
-
Y
N
L
G
A
D
T
V
L
L
I
V
K
I
L
T
E
--
R
E
L
E
S
L
L
E
Y
A
R
S
Y
G
M
E
P
L
I
E
I
N
-
D
E
N
D
L
D
I
A
L
R
-
I
G
A
R
F
I
G
I
N
S
R
D
L
E
T
L
E
I
N
K
E
N
Q
R
K
L
I
S
M
I
P
---
S
-------
N
V
V
K
V
A
E
S
G
I
S
E
R
N
E
I
E
E
L
R
-
K
L
G
V
N
--
A
F
L
I
G
S
S
L
M
R
N
P
E
K
I
K
E
F
I
L
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
26
PsiBlast_CBE
63.23
31%
-94
- C6 -
3UY7
2
?
B:
[2-248]
-
P
R
Y
L
K
G
A
L
K
D
V
V
QLS
L
R
R
P
S
L
R
A
---
S
R
Q
R
P
---
I
-----
I
S
L
R
E
R
IL
E
F
N
K
R
N
I
--------
T
A
----
I
I
A
V
Y
K
R
K
S
P
S
G
L
D
V
E
R
D
--
P
I
E
Y
A
K
F
M
-
E
R
Y
-
A
V
G
L
V
I
L
T
E
E
K
Y
F
N
G
S
Y
E
D
L
R
K
I
A
S
S
V
S
I
-
P
I
L
M
W
D
F
I
V
K
E
S
Q
I
D
D
A
-
Y
N
L
G
A
D
T
V
S
L
I
V
K
I
L
T
E
--
R
E
L
E
S
L
L
E
Y
A
R
S
Y
G
M
E
P
A
I
V
I
N
-
D
E
E
D
L
D
I
A
L
R
-
I
G
A
R
I
I
I
I
S
S
R
D
L
E
T
L
E
I
N
K
E
N
Q
R
K
L
I
S
M
I
P
---
S
-------
N
V
V
K
V
A
A
S
G
I
S
E
R
N
E
I
E
E
L
R
-
K
L
G
V
N
--
A
F
E
I
G
S
S
L
M
R
N
P
E
K
I
K
---
E
L
I
L
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
27
PsiBlast_CBE
62.85
31%
-92
- C6 -
3UY7
5
?
A:
[2-248]
-
P
R
Y
L
K
G
A
L
K
D
V
V
Q
L
S
L
R
R
P
S
L
R
A
---
S
R
Q
R
P
---
I
-----
I
S
L
R
E
R
I
L
E
F
N
K
R
N
I
--------
T
A
----
I
I
A
V
Y
K
R
K
S
P
S
G
L
D
V
E
R
D
--
P
I
E
Y
A
K
F
M
-
E
R
Y
-
A
V
G
L
V
I
L
T
E
E
K
Y
F
N
G
S
Y
E
D
L
R
K
I
A
S
S
V
S
I
-
P
I
L
M
W
D
F
I
V
K
E
S
Q
I
D
D
A
-
Y
N
L
G
A
D
T
V
S
L
I
V
K
I
L
T
E
--
R
E
L
E
S
L
L
E
Y
A
R
S
Y
G
M
E
P
A
I
V
I
N
-
D
E
E
D
L
D
I
A
L
R
-
I
G
A
R
I
I
I
I
S
S
R
D
L
E
T
L
E
I
N
K
E
N
Q
R
K
L
I
S
M
I
P
---
S
-------
N
V
V
K
V
A
A
S
G
I
S
E
R
N
E
I
E
E
L
R
-
K
L
G
V
N
--
A
F
E
I
G
S
S
L
M
R
N
P
E
K
I
K
---
E
L
I
L
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
9
PsiBlast_PDB
62.43
34%
-100
- C6 -
1JUL
1
TRPC_SULSO
A:
[2-238]
-
P
R
Y
L
K
G
W
L
K
D
V
V
Q
L
S
L
R
R
P
S
F
R
A
---
S
R
Q
R
P
---
I
-----
I
S
L
N
E
R
I
L
E
F
N
K
R
N
I
--------
T
A
----
I
I
A
E
Y
K
R
K
S
P
S
G
L
D
V
E
R
D
--
P
I
E
Y
S
K
F
M
-
E
R
Y
-
A
V
G
L
S
I
L
T
E
E
K
Y
F
N
G
S
Y
E
T
L
R
K
I
A
S
S
V
S
I
-
P
I
L
M
K
D
F
I
V
K
E
S
Q
I
D
D
A
-
Y
N
L
G
A
D
T
V
L
L
I
V
K
I
L
T
E
--
R
E
L
E
S
L
L
E
Y
A
R
S
Y
G
M
E
P
L
I
E
I
N
-
D
E
N
D
L
D
I
A
L
R
-
I
G
A
R
F
I
G
I
N
S
R
D
L
E
T
L
E
I
N
K
E
N
Q
R
K
L
I
S
M
I
P
---
S
-------
N
V
V
K
V
A
E
S
G
I
S
E
R
N
E
I
E
E
L
R
-
K
L
G
V
N
--
A
F
L
I
G
S
S
L
M
R
N
P
E
K
I
K
E
F
I
L
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
10
PsiBlast_PDB
62.41
35%
-106
- C6 -
1LBF
1
TRPC_SULSO
A:
[45-237]
----------------------------------------------------------------
T
A
----
I
I
A
E
Y
K
R
K
S
P
S
G
L
D
V
E
R
D
--
P
I
E
Y
S
K
F
M
-
E
R
Y
-
A
V
G
L
S
I
L
T
E
E
K
Y
F
N
G
S
Y
E
T
L
R
K
I
A
S
S
V
S
I
-
P
I
L
M
K
D
F
I
V
K
E
S
Q
I
D
D
A
-
Y
N
L
G
A
D
T
V
L
L
I
V
K
I
L
T
E
--
R
E
L
E
S
L
L
E
Y
A
R
S
Y
G
M
E
P
L
I
E
I
N
-
D
E
N
D
L
D
I
A
L
R
-
I
G
A
R
F
I
G
I
N
S
R
D
L
E
T
L
E
I
N
K
E
N
Q
R
K
L
I
S
M
I
P
---
S
-------
N
V
V
K
V
A
E
S
G
I
S
E
R
N
E
I
E
E
L
R
-
K
L
G
V
N
--
A
F
L
I
G
S
S
L
M
R
N
P
E
K
I
K
E
F
I
L
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
11
PsiBlast_PDB
62.25
35%
-109
- C6 -
1LBL
1
TRPC_SULSO
A:
[45-237]
----------------------------------------------------------------
T
A
----
I
I
A
E
Y
K
R
K
S
P
S
G
L
D
V
E
R
D
--
P
I
E
Y
S
K
F
M
-
E
R
Y
-
A
V
G
L
S
I
L
T
E
E
K
Y
F
N
G
S
Y
E
T
L
R
K
I
A
S
S
V
S
I
-
P
I
L
M
K
D
F
I
V
K
E
S
Q
I
D
D
A
-
Y
N
L
G
A
D
T
V
L
L
I
V
K
I
L
T
E
--
R
E
L
E
S
L
L
E
Y
A
R
S
Y
G
M
E
P
L
I
E
I
N
-
D
E
N
D
L
D
I
A
L
R
-
I
G
A
R
F
I
G
I
N
S
R
D
L
E
T
L
E
I
N
K
E
N
Q
R
K
L
I
S
M
I
P
---
S
-------
N
V
V
K
V
A
E
S
G
I
S
E
R
N
E
I
E
E
L
R
-
K
L
G
V
N
--
A
F
L
I
G
S
S
L
M
R
N
P
E
K
I
K
E
F
I
L
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------