@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : Lmo1217: (2016-03-22 )
MDEQLKMLKALTDAKGIPGNERAVRNVFREYIEPLADSFETDGLGSAVAKKVGAEDGPKIMIAGHLDEVGFMVTQIDDKGFIKFQTVGGWVSQVMLAQKVTIVTRSGEEITGVIGSKPPHVMTAADRQKSFDIKDMFIDVGAVDKAEVESYGIRPGDMIVPAFDFTVMKNEKFLLAKAWDNRIGLAIAIEVLKNLQKEQHPNIVYGVGTVQEEVGLRGAKTAAHFVQPDIGFAVDVGIAGDTPGVTDKEAMSKMGEGPQIVIYDASMVAHAGLRDFVTDVADELSIPYQFEAIPMGGTDSGSIHLTGNGIPSLSITIATRYIHSHSSMLHRDDFENAVKLITEVVKRLDKEKVTEIRLG
Atome Classification :
(20 SA)
.........10........20-........30........40........-50...-.....60........70........80........90........100.......110.......120.......130........140.......150.......160.......170.......180.......190.......200.......210.......220.......230.......240--.......250.......260.......270.......280.......290.......300.......310.......320.......330.......340.......350.......
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
M
D
E
Q
L
K
M
L
K
A
L
T
DAKGIPG
N
E
-
R
A
V
R
N
V
F
R
E
Y
I
E
P
L
A
D
SFETDG
L
G
S
A
V
A
-
K
K
VGA-EDG
P
K
I
M
I
A
GHLDEV
G
F
M
V
T
QIDDK
G
F
I
K
F
Q
T
V
G
G
W
V
S
Q
V
M
L
A
Q
K
V
T
I
V
TRSGE
E
I
T
G
VIGSKPP
H
V
M
T
A
A
D
RQKS-FD
I
K
D
M
F
I
DVGAV
D
K
A
E
V
E
SYGIRPG
D
M
I
V
P
AF
D
F
T
V
MKNE
K
F
L
L
A
K
AWDNRI
G
L
A
I
A
I
E
V
L
K
N
L
Q
K
EQHP
N
I
V
Y
GVG
T
V
Q
E
E
VGLRGA
K
T
A
A
H
FVQPDI
G
F
A
V
D
VGIAGDT--PGVT
D
K
E
A
M
S
KMGEG
P
Q
I
V
I
Y
D
A
S
M
V
A
H
AG
L
R
D
F
V
T
D
V
A
D
ELSI
P
Y
Q
F
E
AIPMGGTDS
G
S
I
H
L
TGNGIP
S
L
S
I
T
I
A
T
R
Y
I
H
S
H
S
S
M
L
H
R
D
D
F
E
N
A
V
K
L
I
T
E
V
V
K
R
L
D
K
E
K
V
TEIRLG
59
HHSearch
97.67
74%
-91
- C4 -
1VHE
1
YSDC_BACSU
A:
[7-360]
-
D
E
T
L
T
M
L
K
D
L
T
D
A
K
G
I
P
G
N
E
-
R
E
V
R
Q
V
M
K
S
Y
I
E
P
F
A
D
E
V
T
T
D
R
L
G
S
L
I
A
-
K
K
T
G
A
-
E
N
G
P
K
I
M
I
A
G
H
L
D
E
V
G
F
M
V
T
Q
I
T
D
K
G
F
I
R
F
Q
T
V
G
G
W
W
A
Q
V
M
L
A
Q
R
V
T
I
V
T
K
-
K
G
E
I
T
G
V
I
G
S
K
P
P
H
I
L
S
P
E
A
R
K
K
S
-
V
E
I
K
D
M
F
I
D
I
G
A
S
S
R
E
E
A
L
E
W
G
V
L
P
G
D
M
I
V
P
H
F
E
F
T
V
M
N
N
E
K
F
L
L
A
K
A
W
D
N
R
I
G
C
A
I
A
I
D
V
L
R
N
L
Q
N
T
D
H
P
N
I
V
Y
G
V
G
T
V
Q
E
E
V
G
L
R
G
A
K
T
A
A
H
T
I
Q
P
D
I
A
F
G
V
D
V
G
I
A
G
D
T
--
P
G
I
S
E
K
E
A
Q
S
K
M
G
K
G
P
Q
I
I
V
Y
D
A
S
M
V
S
H
K
G
L
R
D
A
V
V
A
T
A
E
E
A
G
I
P
Y
Q
F
D
A
I
A
G
G
G
T
D
S
G
A
I
H
L
T
A
N
G
V
P
A
L
S
I
T
I
A
T
R
Y
I
H
T
H
A
A
M
L
H
R
D
D
Y
E
N
A
V
K
L
I
T
E
V
I
K
K
L
D
R
K
T
V
D
E
I
---
1
PsiBlast_PDB
97.34
71%
-92
- C4 -
1VHE
1
YSDC_BACSU
A:
[6-360]
L
D
E
T
L
T
M
L
K
D
L
T
D
A
K
G
I
P
G
N
E
-
R
E
V
R
Q
V
M
K
S
Y
I
E
P
F
A
D
E
V
T
T
D
R
L
G
S
L
I
A
-
K
K
T
G
A
-
E
N
G
P
K
I
M
I
A
G
H
L
D
E
V
G
F
M
V
T
Q
I
T
D
K
G
F
I
R
F
Q
T
V
G
G
W
W
A
Q
V
M
L
A
Q
R
V
T
I
V
T
K
K
G
E
-
I
T
G
V
I
G
S
K
P
P
H
I
L
S
P
E
A
R
K
K
S
-
V
E
I
K
D
M
F
I
D
I
G
A
S
S
R
E
E
A
L
E
W
G
V
L
P
G
D
M
I
V
P
H
F
E
F
T
V
M
N
N
E
K
F
L
L
A
K
A
W
D
N
R
I
G
C
A
I
A
I
D
V
L
R
N
L
Q
N
T
D
H
P
N
I
V
Y
G
V
G
T
V
Q
E
E
V
G
L
R
G
A
K
T
A
A
H
T
I
Q
P
D
I
A
F
G
V
D
V
G
I
A
G
D
T
--
P
G
I
S
E
K
E
A
Q
S
K
M
G
K
G
P
Q
I
I
V
Y
D
A
S
M
V
S
H
K
G
L
R
D
A
V
V
A
T
A
E
E
A
G
I
P
Y
Q
F
D
A
I
A
G
G
G
T
D
S
G
A
I
H
L
T
A
N
G
V
P
A
L
S
I
T
I
A
T
R
Y
I
H
T
H
A
A
M
L
H
R
D
D
Y
E
N
A
V
K
L
I
T
E
V
I
K
K
L
D
R
K
T
V
D
E
I
---
21
PsiBlast_CBE
78.18
38%
-83
- C4 -
3KL9
5
?
L:
[4-353]
--
T
L
F
S
K
I
K
E
V
T
E
L
A
A
V
S
G
H
E
-
A
P
V
R
A
Y
L
R
E
K
L
T
P
H
V
D
E
V
V
T
D
G
L
G
G
I
F
G
I
K
H
S
E
A
-
V
D
A
P
R
V
L
V
A
S
H
M
D
E
V
G
F
M
V
S
E
I
K
P
D
G
T
F
R
V
V
E
I
G
G
W
N
P
M
V
V
S
S
Q
R
F
K
L
L
T
R
D
G
H
E
I
P
V
I
S
G
----------------
P
A
I
A
D
I
V
F
D
G
G
F
A
D
K
A
E
A
E
S
F
G
I
R
P
G
D
T
I
V
P
D
S
S
A
I
L
T
A
N
E
K
N
I
I
S
K
A
W
D
N
R
Y
G
V
L
M
V
S
E
L
A
E
A
L
S
G
Q
K
L
G
N
E
L
Y
L
G
S
N
V
Q
E
E
V
G
L
R
G
A
H
T
S
T
T
K
F
D
P
E
V
F
L
A
V
D
C
S
P
A
G
D
V
--
Y
G
-----
G
Q
G
K
I
G
D
G
T
L
I
R
F
Y
D
P
G
H
L
L
L
P
G
M
K
D
F
L
L
T
T
A
E
E
A
G
I
K
Y
Q
Y
Y
C
-
G
K
G
G
T
D
A
G
A
A
H
L
K
N
G
G
V
P
S
T
T
I
G
V
C
A
R
Y
I
H
S
H
Q
T
L
Y
A
M
D
D
F
L
E
A
Q
A
F
L
Q
A
L
V
K
K
L
D
R
S
T
V
D
L
I
K
--
31
PsiBlast_CBE
78.16
38%
-84
- C4 -
3KL9
2
?
B:
[4-353]
--
T
L
F
S
K
I
K
E
V
T
E
L
A
A
V
S
G
H
E
-
A
P
V
R
A
Y
L
R
E
K
L
T
P
H
V
D
E
V
V
T
D
G
L
G
G
I
F
G
I
K
H
S
E
A
-
V
D
A
P
R
V
L
V
A
S
H
M
D
E
V
G
F
M
V
S
E
I
K
P
D
G
T
F
R
V
V
E
I
G
G
W
N
P
M
V
V
S
S
Q
R
F
K
L
L
T
R
D
G
H
E
I
P
V
I
S
G
----------------
P
A
I
A
D
I
V
F
D
G
G
F
A
D
K
A
E
A
E
S
F
G
I
R
P
G
D
T
I
V
P
D
S
S
A
I
L
T
A
N
E
K
N
I
I
S
K
A
W
D
N
R
Y
G
V
L
M
V
S
E
L
A
E
A
L
S
G
Q
K
L
G
N
E
L
Y
L
G
S
N
V
Q
E
E
V
G
L
R
G
A
H
T
S
T
T
K
F
D
P
E
V
F
L
A
V
D
C
S
P
A
G
D
V
--
Y
G
-----
G
Q
G
K
I
G
D
G
T
L
I
R
F
Y
D
P
G
H
L
L
L
P
G
M
K
D
F
L
L
T
T
A
E
E
A
G
I
K
Y
Q
Y
Y
C
-
G
K
G
G
T
D
A
G
A
A
H
L
K
N
G
G
V
P
S
T
T
I
G
V
C
A
R
Y
I
H
S
H
Q
T
L
Y
A
M
D
D
F
L
E
A
Q
A
F
L
Q
A
L
V
K
K
L
D
R
S
T
V
D
L
I
K
--
32
PsiBlast_CBE
77.96
37%
-85
- C4 -
1XFO
2
TET_PYRHO
D:
[14-357]
-----
E
L
L
K
K
V
V
E
A
P
G
V
S
G
Y
E
F
L
G
I
R
D
V
V
I
E
E
I
K
D
Y
V
D
E
V
K
V
D
K
L
G
N
V
I
A
-
H
K
K
G
---
E
G
P
K
V
M
I
A
A
H
M
D
Q
I
G
L
M
V
T
H
I
E
K
N
G
F
L
R
V
A
P
I
G
G
V
D
P
K
T
L
I
A
Q
R
F
K
V
W
I
D
K
G
K
F
I
Y
G
V
G
A
S
V
P
-----------
A
-
P
D
W
D
Q
I
F
I
D
I
G
A
E
S
K
E
E
A
E
D
M
G
V
K
I
G
T
V
I
T
W
D
G
R
L
E
R
L
G
K
H
R
F
V
-
S
I
A
F
D
D
R
I
A
V
Y
T
I
L
E
V
A
K
Q
L
K
D
A
K
A
D
--
V
Y
F
V
A
T
V
Q
E
E
V
G
L
R
G
A
R
T
S
A
F
G
I
E
P
D
Y
G
F
A
I
D
V
T
I
A
A
D
I
--
P
G
T
P
E
H
K
Q
V
T
H
L
G
K
G
T
A
I
K
I
M
D
R
S
V
I
C
H
P
T
I
V
R
W
L
E
E
L
A
K
K
H
E
I
P
Y
Q
L
E
I
L
L
G
G
G
T
D
A
G
A
I
H
L
T
K
A
G
V
P
T
G
A
L
S
V
P
A
R
Y
I
H
S
N
T
E
V
V
D
E
R
D
V
D
A
T
V
E
L
M
T
K
A
L
E
N
I
H
E
L
K
I
------
30
PsiBlast_CBE
77.92
38%
-82
- C4 -
3KL9
2
?
C:
[4-353]
--
T
L
F
S
K
I
K
E
V
T
E
L
A
A
V
S
G
H
E
-
A
P
V
R
A
Y
L
R
E
K
L
T
P
H
V
D
E
V
V
T
D
G
L
G
G
I
F
G
I
K
H
S
E
A
-
V
D
A
P
R
V
L
V
A
S
H
M
D
E
V
G
F
M
V
S
E
I
K
P
D
G
T
F
R
V
V
E
I
G
G
W
N
P
M
V
V
S
S
Q
R
F
K
L
L
T
R
D
G
H
E
I
P
V
I
S
G
----------------
P
A
I
A
D
I
V
F
D
G
G
F
A
D
K
A
E
A
E
S
F
G
I
R
P
G
D
T
I
V
P
D
S
S
A
I
L
T
A
N
E
K
N
I
I
S
K
A
W
D
N
R
Y
G
V
L
M
V
S
E
L
A
E
A
L
S
G
Q
K
L
G
N
E
L
Y
L
G
S
N
V
Q
E
E
V
G
L
R
G
A
H
T
S
T
T
K
F
D
P
E
V
F
L
A
V
D
C
S
P
A
G
D
V
--
Y
G
-----
G
Q
G
K
I
G
D
G
T
L
I
R
F
Y
D
P
G
H
L
L
L
P
G
M
K
D
F
L
L
T
T
A
E
E
A
G
I
K
Y
Q
Y
Y
C
-
G
K
G
G
T
D
A
G
A
A
H
L
K
N
G
G
V
P
S
T
T
I
G
V
C
A
R
Y
I
H
S
H
Q
T
L
Y
A
M
D
D
F
L
E
A
Q
A
F
L
Q
A
L
V
K
K
L
D
R
S
T
V
D
L
I
K
--
4
PsiBlast_PDB
77.92
37%
-84
- C4 -
1XFO
4
TET_PYRHO
A:
[14-357]
-----
E
L
L
K
K
V
V
E
A
P
G
V
S
G
Y
E
F
L
G
I
R
D
V
V
I
E
E
I
K
D
Y
V
D
E
V
K
V
D
K
L
G
N
V
I
A
-
H
K
K
G
---
E
G
P
K
V
M
I
A
A
H
M
D
Q
I
G
L
M
V
T
H
I
E
K
N
G
F
L
R
V
A
P
I
G
G
V
D
P
K
T
L
I
A
Q
R
F
K
V
W
I
D
K
G
K
F
I
Y
G
V
G
A
S
V
P
-----------
A
-
P
D
W
D
Q
I
F
I
D
I
G
A
E
S
K
E
E
A
E
D
M
G
V
K
I
G
T
V
I
T
W
D
G
R
L
E
R
L
G
K
H
R
F
V
-
S
I
A
F
D
D
R
I
A
V
Y
T
I
L
E
V
A
K
Q
L
K
D
A
K
A
D
--
V
Y
F
V
A
T
V
Q
E
E
V
G
L
R
G
A
R
T
S
A
F
G
I
E
P
D
Y
G
F
A
I
D
V
T
I
A
A
D
I
--
P
G
T
P
E
H
K
Q
V
T
H
L
G
K
G
T
A
I
K
I
M
D
R
S
V
I
C
H
P
T
I
V
R
W
L
E
E
L
A
K
K
H
E
I
P
Y
Q
L
E
I
L
L
G
G
G
T
D
A
G
A
I
H
L
T
K
A
G
V
P
T
G
A
L
S
V
P
A
R
Y
I
H
S
N
T
E
V
V
D
E
R
D
V
D
A
T
V
E
L
M
T
K
A
L
E
N
I
H
E
L
K
I
------
28
PsiBlast_CBE
77.79
38%
-81
- C4 -
3KL9
2
?
E:
[2-353]
M
T
T
L
F
S
K
I
K
E
V
T
E
L
A
A
V
S
G
H
E
-
A
P
V
R
A
Y
L
R
E
K
L
T
P
H
V
D
E
V
V
T
D
G
L
G
G
I
F
G
I
K
H
S
E
A
-
V
D
A
P
R
V
L
V
A
S
H
M
D
E
V
G
F
M
V
S
E
I
K
P
D
G
T
F
R
V
V
E
I
G
G
W
N
P
M
V
V
S
S
Q
R
F
K
L
L
T
R
D
G
H
E
I
P
V
I
S
G
----------------
P
A
I
A
D
I
V
F
D
G
G
F
A
D
K
A
E
A
E
S
F
G
I
R
P
G
D
T
I
V
P
D
S
S
A
I
L
T
A
N
E
K
N
I
I
S
K
A
W
D
N
R
Y
G
V
L
M
V
S
E
L
A
E
A
L
S
G
Q
K
L
G
N
E
L
Y
L
G
S
N
V
Q
E
E
V
G
L
R
G
A
H
T
S
T
T
K
F
D
P
E
V
F
L
A
V
D
C
S
P
A
G
D
V
--
Y
G
-----
G
Q
G
K
I
G
D
G
T
L
I
R
F
Y
D
P
G
H
L
L
L
P
G
M
K
D
F
L
L
T
T
A
E
E
A
G
I
K
Y
Q
Y
Y
C
-
G
K
G
G
T
D
A
G
A
A
H
L
K
N
G
G
V
P
S
T
T
I
G
V
C
A
R
Y
I
H
S
H
Q
T
L
Y
A
M
D
D
F
L
E
A
Q
A
F
L
Q
A
L
V
K
K
L
D
R
S
T
V
D
L
I
K
--
2
PsiBlast_PDB
77.66
38%
-79
- C4 -
3KL9
2
?
A:
[2-353]
M
T
T
L
F
S
K
I
K
E
V
T
E
L
A
A
V
S
G
H
E
-
A
P
V
R
A
Y
L
R
E
K
L
T
P
H
V
D
E
V
V
T
D
G
L
G
G
I
F
G
I
K
H
S
E
A
-
V
D
A
P
R
V
L
V
A
S
H
M
D
E
V
G
F
M
V
S
E
I
K
P
D
G
T
F
R
V
V
E
I
G
G
W
N
P
M
V
V
S
S
Q
R
F
K
L
L
T
R
D
G
H
E
I
P
V
I
S
G
----------------
P
A
I
A
D
I
V
F
D
G
G
F
A
D
K
A
E
A
E
S
F
G
I
R
P
G
D
T
I
V
P
D
S
S
A
I
L
T
A
N
E
K
N
I
I
S
K
A
W
D
N
R
Y
G
V
L
M
V
S
E
L
A
E
A
L
S
G
Q
K
L
G
N
E
L
Y
L
G
S
N
V
Q
E
E
V
G
L
R
G
A
H
T
S
T
T
K
F
D
P
E
V
F
L
A
V
D
C
S
P
A
G
D
V
--
Y
G
-----
G
Q
G
K
I
G
D
G
T
L
I
R
F
Y
D
P
G
H
L
L
L
P
G
M
K
D
F
L
L
T
T
A
E
E
A
G
I
K
Y
Q
Y
Y
C
-
G
K
G
G
T
D
A
G
A
A
H
L
K
N
G
G
V
P
S
T
T
I
G
V
C
A
R
Y
I
H
S
H
Q
T
L
Y
A
M
D
D
F
L
E
A
Q
A
F
L
Q
A
L
V
K
K
L
D
R
S
T
V
D
L
I
K
--
27
PsiBlast_CBE
77.60
38%
-81
- C4 -
3KL9
2
?
F:
[4-353]
--
T
L
F
S
K
I
K
E
V
T
E
L
A
A
V
S
G
H
E
-
A
P
V
R
A
Y
L
R
E
K
L
T
P
H
V
D
E
V
V
T
D
G
L
G
G
I
F
G
I
K
H
S
E
A
-
V
D
A
P
R
V
L
V
A
S
H
M
D
E
V
G
F
M
V
S
E
I
K
P
D
G
T
F
R
V
V
E
I
G
G
W
N
P
M
V
V
S
S
Q
R
F
K
L
L
T
R
D
G
H
E
I
P
V
I
S
G
----------------
P
A
I
A
D
I
V
F
D
G
G
F
A
D
K
A
E
A
E
S
F
G
I
R
P
G
D
T
I
V
P
D
S
S
A
I
L
T
A
N
E
K
N
I
I
S
K
A
W
D
N
R
Y
G
V
L
M
V
S
E
L
A
E
A
L
S
G
Q
K
L
G
N
E
L
Y
L
G
S
N
V
Q
E
E
V
G
L
R
G
A
H
T
S
T
T
K
F
D
P
E
V
F
L
A
V
D
C
S
P
A
G
D
V
--
Y
G
-----
G
Q
G
K
I
G
D
G
T
L
I
R
F
Y
D
P
G
H
L
L
L
P
G
M
K
D
F
L
L
T
T
A
E
E
A
G
I
K
Y
Q
Y
Y
C
-
G
K
G
G
T
D
A
G
A
A
H
L
K
N
G
G
V
P
S
T
T
I
G
V
C
A
R
Y
I
H
S
H
Q
T
L
Y
A
M
D
D
F
L
E
A
Q
A
F
L
Q
A
L
V
K
K
L
D
R
S
T
V
D
L
I
K
--
29
PsiBlast_CBE
77.59
38%
-81
- C4 -
3KL9
2
?
D:
[2-353]
M
T
T
L
F
S
K
I
K
E
V
T
E
L
A
A
V
S
G
H
E
-
A
P
V
R
A
Y
L
R
E
K
L
T
P
H
V
D
E
V
V
T
D
G
L
G
G
I
F
G
I
K
H
S
E
A
-
V
D
A
P
R
V
L
V
A
S
H
M
D
E
V
G
F
M
V
S
E
I
K
P
D
G
T
F
R
V
V
E
I
G
G
W
N
P
M
V
V
S
S
Q
R
F
K
L
L
T
R
D
G
H
E
I
P
V
I
S
G
----------------
P
A
I
A
D
I
V
F
D
G
G
F
A
D
K
A
E
A
E
S
F
G
I
R
P
G
D
T
I
V
P
D
S
S
A
I
L
T
A
N
E
K
N
I
I
S
K
A
W
D
N
R
Y
G
V
L
M
V
S
E
L
A
E
A
L
S
G
Q
K
L
G
N
E
L
Y
L
G
S
N
V
Q
E
E
V
G
L
R
G
A
H
T
S
T
T
K
F
D
P
E
V
F
L
A
V
D
C
S
P
A
G
D
V
--
Y
G
-----
G
Q
G
K
I
G
D
G
T
L
I
R
F
Y
D
P
G
H
L
L
L
P
G
M
K
D
F
L
L
T
T
A
E
E
A
G
I
K
Y
Q
Y
Y
C
-
G
K
G
G
T
D
A
G
A
A
H
L
K
N
G
G
V
P
S
T
T
I
G
V
C
A
R
Y
I
H
S
H
Q
T
L
Y
A
M
D
D
F
L
E
A
Q
A
F
L
Q
A
L
V
K
K
L
D
R
S
T
V
D
L
I
K
--
56
HHSearch
77.48
39%
-79
- C4 -
3KL9
2
?
A:
[2-352]
M
T
T
L
F
S
K
I
K
E
V
T
E
L
A
A
V
S
G
H
E
-
A
P
V
R
A
Y
L
R
E
K
L
T
P
H
V
D
E
V
V
T
D
G
L
G
G
I
F
G
-
I
K
H
S
E
A
V
D
A
P
R
V
L
V
A
S
H
M
D
E
V
G
F
M
V
S
E
I
K
P
D
G
T
F
R
V
V
E
I
G
G
W
N
P
M
V
V
S
S
Q
R
F
K
L
L
T
R
D
G
H
E
I
P
V
I
S
G
----------------
P
A
I
A
D
I
V
F
D
G
G
F
A
D
K
A
E
A
E
S
F
G
I
R
P
G
D
T
I
V
P
D
S
S
A
I
L
T
A
N
E
K
N
I
I
S
K
A
W
D
N
R
Y
G
V
L
M
V
S
E
L
A
E
A
L
S
G
Q
K
L
G
N
E
L
Y
L
G
S
N
V
Q
E
E
V
G
L
R
G
A
H
T
S
T
T
K
F
D
P
E
V
F
L
A
V
D
C
S
P
A
G
D
V
--
Y
G
G
Q
-----
G
K
I
G
D
G
T
L
I
R
F
Y
D
P
G
H
L
L
L
P
G
M
K
D
F
L
L
T
T
A
E
E
A
G
I
K
Y
Q
Y
Y
C
-
G
K
G
G
T
D
A
G
A
A
H
L
K
N
G
G
V
P
S
T
T
I
G
V
C
A
R
Y
I
H
S
H
Q
T
L
Y
A
M
D
D
F
L
E
A
Q
A
F
L
Q
A
L
V
K
K
L
D
R
S
T
V
D
L
I
---
33
PsiBlast_CBE
77.11
37%
-83
- C4 -
1XFO
2
TET_PYRHO
C:
[14-357]
-----
E
L
L
K
K
V
V
E
A
P
G
V
S
G
Y
E
F
L
G
I
R
D
V
V
I
E
E
I
K
D
Y
V
D
E
V
K
V
D
K
L
G
N
V
I
A
-
H
K
K
G
---
E
G
P
K
V
M
I
A
A
H
M
D
Q
I
G
L
M
V
T
H
I
E
K
N
G
F
L
R
V
A
P
I
G
G
V
D
P
K
T
L
I
A
Q
R
F
K
V
W
I
D
K
G
K
F
I
Y
G
V
G
A
S
V
P
-----------
A
-
P
D
W
D
Q
I
F
I
D
I
G
A
E
S
K
E
E
A
E
D
M
G
V
K
I
G
T
V
I
T
W
D
G
R
L
E
R
L
G
K
H
R
F
V
-
S
I
A
F
D
D
R
I
A
V
Y
T
I
L
E
V
A
K
Q
L
K
D
A
K
A
D
--
V
Y
F
V
A
T
V
Q
E
E
V
G
L
R
G
A
R
T
S
A
F
G
I
E
P
D
Y
G
F
A
I
D
V
T
I
A
A
D
I
--
P
G
T
P
E
H
K
Q
V
T
H
L
G
K
G
T
A
I
K
I
M
D
R
S
V
I
C
H
P
T
I
V
R
W
L
E
E
L
A
K
K
H
E
I
P
Y
Q
L
E
I
L
L
G
G
G
T
D
A
G
A
I
H
L
T
K
A
G
V
P
T
G
A
L
S
V
P
A
R
Y
I
H
S
N
T
E
V
V
D
E
R
D
V
D
A
T
V
E
L
M
T
K
A
L
E
N
I
H
E
L
K
I
------
26
PsiBlast_CBE
76.80
38%
-79
- C4 -
3KL9
2
?
G:
[4-353]
--
T
L
F
S
K
I
K
E
V
T
E
L
A
A
V
S
G
H
E
-
A
P
V
R
A
Y
L
R
E
K
L
T
P
H
V
D
E
V
V
T
D
G
L
G
G
I
F
G
I
K
H
S
E
A
-
V
D
A
P
R
V
L
V
A
S
H
M
D
E
V
G
F
M
V
S
E
I
K
P
D
G
T
F
R
V
V
E
I
G
G
W
N
P
M
V
V
S
S
Q
R
F
K
L
L
T
R
D
G
H
E
I
P
V
I
S
G
----------------
P
A
I
A
D
I
V
F
D
G
G
F
A
D
K
A
E
A
E
S
F
G
I
R
P
G
D
T
I
V
P
D
S
S
A
I
L
T
A
N
E
K
N
I
I
S
K
A
W
D
N
R
Y
G
V
L
M
V
S
E
L
A
E
A
L
S
G
Q
K
L
G
N
E
L
Y
L
G
S
N
V
Q
E
E
V
G
L
R
G
A
H
T
S
T
T
K
F
D
P
E
V
F
L
A
V
D
C
S
P
A
G
D
V
--
Y
G
-----
G
Q
G
K
I
G
D
G
T
L
I
R
F
Y
D
P
G
H
L
L
L
P
G
M
K
D
F
L
L
T
T
A
E
E
A
G
I
K
Y
Q
Y
Y
C
-
G
K
G
G
T
D
A
G
A
A
H
L
K
N
G
G
V
P
S
T
T
I
G
V
C
A
R
Y
I
H
S
H
Q
T
L
Y
A
M
D
D
F
L
E
A
Q
A
F
L
Q
A
L
V
K
K
L
D
R
S
T
V
D
L
I
K
--
5
PsiBlast_PDB
73.80
33%
-80
- C4 -
1YLO
2
?
A:
[6-344]
----
L
S
L
L
K
A
L
S
E
A
D
A
I
A
S
S
E
-
Q
E
V
R
Q
I
L
L
E
E
A
A
R
L
Q
K
E
V
R
F
D
G
L
G
S
-
V
L
-
I
R
L
N
E
-
S
T
G
P
K
V
M
I
C
A
H
M
D
E
V
G
F
M
V
R
S
I
S
R
E
G
A
I
D
V
L
P
V
G
N
V
R
M
A
A
R
Q
L
Q
P
V
R
I
T
T
R
E
E
C
K
I
P
G
L
L
D
---------
G
D
R
Q
G
N
--
D
V
S
A
M
R
V
D
I
G
A
R
T
Y
D
E
V
M
Q
A
G
I
R
P
G
D
R
V
T
F
D
T
T
F
Q
V
L
P
H
Q
R
-
V
M
G
K
A
F
D
D
R
L
S
C
Y
L
L
V
T
L
L
R
E
L
H
D
A
E
L
P
A
E
V
W
L
V
A
S
S
S
E
E
V
G
L
R
G
G
Q
T
A
T
R
A
V
S
P
D
V
A
I
V
L
D
T
A
C
W
A
K
N
FD
Y
G
A
A
N
H
R
---
Q
I
G
N
G
P
M
L
V
L
S
D
K
S
L
I
A
P
P
K
L
T
A
W
I
E
T
V
A
A
E
I
G
V
P
L
Q
A
D
M
F
S
N
G
G
T
D
G
G
A
V
H
L
T
G
T
G
V
P
T
L
V
M
G
P
A
T
R
H
G
H
C
A
A
S
I
A
D
C
R
D
I
L
Q
M
E
Q
L
L
S
A
L
I
Q
R
L
T
R
E
T
V
V
Q
L
---
62
HHSearch
73.78
32%
-100
- C4 -
3ISX
3
?
A:
[12-342]
--
H
M
K
E
L
I
R
K
L
T
E
A
F
G
P
S
G
R
E
-
E
E
V
R
S
I
I
L
E
E
L
E
G
H
I
D
G
H
R
I
D
G
L
G
N
L
I
V
-
W
K
G
S
---
G
E
K
K
V
I
L
D
A
H
I
D
E
I
G
V
V
V
T
N
V
D
D
K
G
F
L
T
I
E
P
V
G
G
V
S
P
Y
M
L
L
G
K
R
I
R
F
E
N
G
----
T
I
G
V
V
G
M
E
G
E
T
T
E
E
R
Q
E
N
V
R
K
-
L
S
F
D
K
L
F
I
D
I
G
A
N
S
R
E
E
A
Q
K
-
M
C
P
I
G
S
F
G
V
Y
D
S
G
F
V
E
V
S
--
G
K
Y
V
S
K
A
M
D
D
R
I
G
C
A
V
I
V
E
V
F
K
R
I
K
---
P
A
V
T
L
Y
G
V
F
S
V
Q
E
E
V
G
L
V
G
A
S
V
A
G
Y
G
V
P
A
D
E
A
I
A
I
D
V
T
D
S
A
D
T
--
P
K
A
I
-
K
R
H
A
M
R
L
S
G
G
P
A
L
K
V
K
D
R
A
S
I
S
S
K
R
I
L
E
N
L
I
E
I
A
E
K
F
D
I
K
Y
Q
M
E
V
L
T
F
G
G
T
N
A
M
G
Y
Q
R
T
R
E
G
I
P
S
A
T
V
S
I
P
T
R
Y
V
H
S
P
S
E
M
I
A
P
D
D
V
E
A
T
V
D
L
L
I
R
Y
L
G
-------------
57
HHSearch
73.61
34%
-83
- C4 -
1YLO
2
?
A:
[3-343]
-
A
M
D
L
S
L
L
K
A
L
S
E
A
D
A
I
A
S
S
E
-
Q
E
V
R
Q
I
L
L
E
E
A
A
R
L
Q
K
E
V
R
F
D
G
L
G
S
V
L
I
-
R
L
N
E
S
--
T
G
P
K
V
M
I
C
A
H
M
D
E
V
G
F
M
V
R
S
I
S
R
E
G
A
I
D
V
L
P
V
G
N
V
R
M
A
A
R
Q
L
Q
P
V
R
I
T
T
R
E
E
C
K
I
P
G
L
L
D
G
----------
D
R
Q
G
-
N
D
V
S
A
M
R
V
D
I
G
A
R
T
Y
D
E
V
M
Q
A
G
I
R
P
G
D
R
V
T
F
D
T
T
F
Q
V
L
P
-
H
Q
R
V
M
G
K
A
F
D
D
R
L
S
C
Y
L
L
V
T
L
L
R
E
L
H
D
A
E
L
P
A
E
V
W
L
V
A
S
S
S
E
E
V
G
L
R
G
G
Q
T
A
T
R
A
V
S
P
D
V
A
I
V
L
D
T
A
C
W
A
K
N
--
F
D
Y
G
A
A
-
N
H
R
Q
I
G
N
G
P
M
L
V
L
S
D
K
S
L
I
A
P
P
K
L
T
A
W
I
E
T
V
A
A
E
I
G
V
P
L
Q
A
D
M
F
S
N
G
G
T
D
G
G
A
V
H
L
T
G
T
G
V
P
T
L
V
M
G
P
A
T
R
H
G
H
C
A
A
S
I
A
D
C
R
D
I
L
Q
M
E
Q
L
L
S
A
L
I
Q
R
L
T
R
E
T
V
V
Q
----
35
PsiBlast_CBE
73.21
32%
-88
- C4 -
2WYR
5
?
L:
[2-325]
-
M
S
M
I
E
K
L
K
K
F
T
Q
I
P
G
I
S
G
Y
E
-
E
R
I
R
E
E
I
I
R
E
I
K
D
F
A
D
-
Y
K
V
D
A
I
G
N
L
I
V
-
E
L
G
E
G
-
E
E
--
R
I
L
F
M
A
H
M
D
E
I
G
L
L
I
T
G
I
T
D
E
G
K
L
R
F
R
K
V
G
G
I
D
D
R
L
L
Y
G
R
H
V
N
V
V
T
E
K
G
I
-
L
D
G
V
I
G
A
T
P
P
H
L
--
S
------V
I
P
W
Y
D
L
V
I
D
I
G
A
E
S
K
E
E
A
L
E
L
-
V
K
P
L
D
F
A
V
F
K
K
H
F
S
V
L
-
N
G
K
Y
V
S
T
R
G
L
D
D
R
F
G
V
V
A
L
I
E
A
I
K
D
L
V
D
H
E
L
E
G
K
V
I
F
A
F
T
V
Q
E
E
V
G
L
K
G
A
K
F
L
A
N
H
Y
Y
P
Q
Y
A
F
A
I
D
-
S
F
A
C
C
S
--
P
L
T
G
D
----
V
K
L
G
K
G
P
V
I
R
A
V
D
N
S
A
I
Y
S
R
D
L
A
R
K
V
W
S
I
A
E
K
N
G
I
E
I
Q
I
-
G
V
T
G
G
G
T
D
A
S
A
F
Q
---
D
R
S
K
T
L
A
L
S
V
P
I
K
Y
L
H
S
E
V
E
T
L
H
L
N
D
L
E
K
L
V
K
L
I
------------------
43
PsiBlast_CBE
72.99
32%
-87
- C4 -
2WYR
2
?
D:
[2-325]
-
M
S
M
I
E
K
L
K
K
F
T
Q
I
P
G
I
S
G
Y
E
-
E
R
I
R
E
E
I
I
R
E
I
K
D
F
A
D
-
Y
K
V
D
A
I
G
N
L
I
V
-
E
L
G
E
G
-
E
E
--
R
I
L
F
M
A
H
M
D
E
I
G
L
L
I
T
G
I
T
D
E
G
K
L
R
F
R
K
V
G
G
I
D
D
R
L
L
Y
G
R
H
V
N
V
V
T
E
K
G
I
-
L
D
G
V
I
G
A
T
P
P
H
L
--
S
------V
I
P
W
Y
D
L
V
I
D
I
G
A
E
S
K
E
E
A
L
E
L
-
V
K
P
L
D
F
A
V
F
K
K
H
F
S
V
L
-
N
G
K
Y
V
S
T
R
G
L
D
D
R
F
G
V
V
A
L
I
E
A
I
K
D
L
V
D
H
E
L
E
G
K
V
I
F
A
F
T
V
Q
E
E
V
G
L
K
G
A
K
F
L
A
N
H
Y
Y
P
Q
Y
A
F
A
I
D
-
S
F
A
C
C
S
--
P
L
T
G
D
----
V
K
L
G
K
G
P
V
I
R
A
V
D
N
S
A
I
Y
S
R
D
L
A
R
K
V
W
S
I
A
E
K
N
G
I
E
I
Q
I
-
G
V
T
G
G
G
T
D
A
S
A
F
Q
---
D
R
S
K
T
L
A
L
S
V
P
I
K
Y
L
H
S
E
V
E
T
L
H
L
N
D
L
E
K
L
V
K
L
I
------------------
64
HHSearch
72.89
31%
-87
* C4 *
2WYR
2
?
A:
[2-332]
-
M
S
M
I
E
K
L
K
K
F
T
Q
I
P
G
I
S
G
Y
E
-
E
R
I
R
E
E
I
I
R
E
I
K
D
F
A
-
D
Y
K
V
D
A
I
G
N
L
I
V
-
E
L
G
E
---
G
E
E
R
I
L
F
M
A
H
M
D
E
I
G
L
L
I
T
G
I
T
D
E
G
K
L
R
F
R
K
V
G
G
I
D
D
R
L
L
Y
G
R
H
V
N
V
V
T
E
-
K
G
I
L
D
G
V
I
G
A
T
P
P
H
L
------
K
S
V
-
I
P
W
Y
D
L
V
I
D
I
G
A
E
S
K
E
E
A
L
E
-
L
V
K
P
L
D
F
A
V
F
K
K
H
F
S
V
L
N
-
G
K
Y
V
S
T
R
G
L
D
D
R
F
G
V
V
A
L
I
E
A
I
K
D
L
V
D
H
E
L
E
G
K
V
I
F
A
F
T
V
Q
E
E
V
G
L
K
G
A
K
F
L
A
N
H
Y
Y
P
Q
Y
A
F
A
I
D
S
F
A
C
C
S
P
--
L
T
G
-----
D
V
K
L
G
K
G
P
V
I
R
A
V
D
N
S
A
I
Y
S
R
D
L
A
R
K
V
W
S
I
A
E
K
N
G
I
E
I
Q
I
G
V
-
T
G
G
G
T
D
A
S
A
F
Q
D
---
R
S
K
T
L
A
L
S
V
P
I
K
Y
L
H
S
E
V
E
T
L
H
L
N
D
L
E
K
L
V
K
L
I
E
A
L
A
F
E
L
-----------