@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : Lmo1414: (2016-03-24 )
MKEVVIIDAVRTPIGKFGGSLKDISAVDLGATALKGVLERANIAPERVDQVIFGNVLQAGLGQNVARQIAIKAGIPYKVPGVTINEVCGSGLKSVMLGRQAIQLGEADIVAVGGTENMSQAPLLLNPELAGEEINPKKLRNSMLIDGLTDVYGEYHMGITAENVAEKFSVTREEQDEFAHNSQMKAASAQEKKLFEEEIIPVKLPDGSFFEADETIRANSTLEKLATLKSVFKEGGTVTAGNASGINDGASAIILMSKEKAVAENIPYIATIKVTSEVGVDPALMGYAPYYAVNEALTKGGYSIDEIDLFHLNEAFASQSVAVARDLKIPEEKLNIYGGAIALGHPIGASGARIIASLLNELKHENKHIGVASLCVGGGIGIAIILERA
Atome Classification :
(22 SA)
.........10........20........30........40.....----...50........60.........70........80........90........100.......110.......120.......130.......140.......150.......160.......170.......180.......190.......200-...-.----------..---..-210-.........220.......230-.--..-....240.......250.......260.......270.......280.......290.......300.......310.......320.......330.......340.......350.......360.......370.......380.......
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MK
E
V
V
I
I
DAVR
T
P
I
G
K
FGGSLKDI
S
A
VD
L
G
A
T
A
L
K
G
V
L
E
R
ANI
A
P
E
----
R
V
D
Q
V
I
F
G
N
V
L
Q
A
G
-
L
G
Q
N
V
A
R
Q
I
AIKAGIPYKVPGV
T
I
N
E
V
C
G
S
G
L
K
S
V
M
L
G
R
Q
A
IQLGEA
D
I
V
A
VGGTENMSQA
P
L
L
LNPELAGEEI
N
P
K
K
L
R
N
S
M
L
ID
G
L
T
D
V
Y
GEYHMGI
T
A
E
N
V
A
E
K
F
SV
T
R
E
E
Q
D
E
F
AHNSQMKAA
S
A
Q
E
K
K
L
F
EEEI
I
P
--
V
KL-P----------DG---SF-F---EADETIRA
N
S
T
L
E
K
L
A
T
L
K
S
V
F
-K--EG-
G
T
V
TAGNASGINDG
A
S
A
I
I
L
M
SK
E
K
A
V
A
ENI
P
Y
I
A
T
I
K
V
T
SEVGV
D
P
A
L
MGYA
P
Y
Y
A
V
N
E
A
L
T
KGGYSI
D
E
I
D
L
F
H
L
N
E
A
F
ASQS
V
A
V
A
RDLKI
P
E
E
K
L
NIYG
G
A
I
A
LGHPIGAS
G
A
R
I
I
A
S
L
L
N
E
L
KHENKHI
G
V
A
S
L
CVGGG
I
G
I
A
I
I
L
ERA
2
PsiBlast_PDB
95.62
53%
-77
- C4 -
4N45
-
?
A:
[1-392]
M
K
E
V
V
I
A
S
A
V
R
T
A
I
G
S
Y
G
K
S
L
K
D
V
P
A
V
D
L
G
A
T
A
I
K
E
A
V
K
K
A
G
I
K
P
E
----
D
V
N
E
V
I
L
G
N
V
L
Q
A
G
-
L
G
Q
N
P
A
R
Q
A
S
F
K
A
G
L
P
V
E
I
P
A
M
T
I
N
K
V
C
G
S
G
L
R
T
V
S
L
A
A
Q
I
I
K
A
G
D
A
D
V
I
I
A
G
G
M
E
N
M
S
R
A
P
Y
L
A
N
N
A
R
W
G
Y
R
M
G
N
A
K
F
V
D
E
M
I
T
D
G
L
W
D
A
F
N
D
Y
H
M
G
I
T
A
E
N
I
A
E
R
W
N
I
S
R
E
E
Q
D
E
F
A
L
A
S
Q
K
K
A
E
E
A
I
K
S
G
Q
F
K
D
E
I
V
P
--
V
V
I
-
K
----------
G
R
K
G
E
T
V
-
V
---
D
T
D
E
H
P
R
F
G
S
T
I
E
G
L
A
K
L
K
P
A
F
-
K
--
K
D
-
G
T
V
T
A
G
N
A
S
G
L
N
D
C
A
A
V
L
V
I
M
S
A
E
K
A
K
E
L
G
V
K
P
L
A
K
I
V
S
Y
G
S
A
G
V
D
P
A
I
M
G
Y
G
P
F
Y
A
T
K
A
A
I
E
K
A
G
W
T
V
D
E
L
D
L
I
E
S
N
E
A
F
A
A
Q
S
L
A
V
A
K
D
L
K
F
D
M
N
K
V
N
V
N
G
G
A
I
A
L
G
H
P
I
G
A
S
G
A
R
I
L
V
T
L
V
H
A
M
Q
K
R
D
A
K
K
G
L
A
T
L
S
I
G
G
G
Q
G
T
A
I
L
L
E
K
C
4
PsiBlast_PDB
94.55
51%
-81
- C4 -
4O99
1
THIL_CUPNH
A:
[2-391]
--
D
V
V
I
V
S
A
A
R
T
A
V
G
K
F
G
G
S
L
A
K
I
P
A
P
E
L
G
A
V
V
I
K
A
A
L
E
R
A
G
V
K
P
E
----
Q
V
S
E
V
I
M
G
Q
V
L
T
A
G
-
S
G
Q
N
P
A
R
Q
A
A
I
K
A
G
L
P
A
M
V
P
A
M
T
I
N
K
V
C
G
S
G
L
K
A
V
M
L
A
A
N
A
I
M
A
G
D
A
E
I
V
V
A
G
G
Q
E
N
M
S
A
A
P
H
V
L
P
G
S
R
D
G
F
R
M
G
D
A
K
L
V
D
T
M
I
V
D
G
L
W
D
V
Y
N
Q
Y
H
M
G
I
T
A
E
N
V
A
K
E
Y
G
I
T
R
E
A
Q
D
E
F
A
V
G
S
Q
N
K
A
E
A
A
Q
K
A
G
K
F
D
E
E
I
V
P
--
V
L
I
-
P
Q
RK
G
------
D
P
---
V
A
-
F
---
K
T
D
E
F
V
R
Q
G
A
T
L
D
S
M
S
G
L
K
P
A
F
-
D
--
K
A
-
G
T
V
T
A
A
N
A
S
G
L
N
D
G
A
A
A
V
V
V
M
S
A
A
K
A
K
E
L
G
L
T
P
L
A
T
I
K
S
Y
A
N
A
G
V
D
P
K
V
M
G
M
G
P
V
P
A
S
K
R
A
L
S
R
A
E
W
T
P
Q
D
L
D
L
M
E
I
N
E
A
F
A
A
Q
A
L
A
V
H
Q
Q
M
G
W
D
T
S
K
V
N
V
N
G
G
A
I
A
I
G
H
P
I
G
A
S
G
C
R
I
L
V
T
L
L
H
E
M
K
R
R
D
A
K
K
G
L
A
S
L
C
I
G
G
G
M
G
V
A
L
A
V
E
R
-
1
PsiBlast_PDB
94.52
53%
-78
- C4 -
4N44
2
?
A:
[1-392]
M
K
E
V
V
I
A
S
A
V
R
T
A
I
G
S
Y
G
K
S
L
K
D
V
P
A
V
D
L
G
A
T
A
I
K
E
A
V
K
K
A
G
I
K
P
E
----
D
V
N
E
V
I
L
G
N
V
L
Q
A
G
-
L
G
Q
N
P
A
R
Q
A
S
F
K
A
G
L
P
V
E
I
P
A
M
T
I
N
K
V
C
G
S
G
L
R
T
V
S
L
A
A
Q
I
I
K
A
G
D
A
D
V
I
I
A
G
G
M
E
N
M
S
R
A
P
Y
L
A
N
N
A
R
W
G
Y
R
M
G
N
A
K
F
V
D
E
M
I
T
D
G
L
W
D
A
F
N
D
Y
H
M
G
I
T
A
E
N
I
A
E
R
W
N
I
S
R
E
E
Q
D
E
F
A
L
A
S
Q
K
K
A
E
E
A
I
K
S
G
Q
F
K
D
E
I
V
P
--
V
V
I
-
K
----------
G
R
K
G
E
T
V
-
V
---
D
T
D
E
H
P
R
F
G
S
T
I
E
G
L
A
K
L
K
P
A
F
-
K
--
K
D
-
G
T
V
T
A
G
N
A
S
G
L
N
D
C
A
A
V
L
V
I
M
S
A
E
K
A
K
E
L
G
V
K
P
L
A
K
I
V
S
Y
G
S
A
G
V
D
P
A
I
M
G
Y
G
P
F
Y
A
T
K
A
A
I
E
K
A
G
W
T
V
D
E
L
D
L
I
E
S
N
E
A
F
A
A
Q
S
L
A
V
A
K
D
L
K
F
D
M
N
K
V
N
V
N
G
G
A
I
A
L
G
H
P
I
G
A
S
G
A
R
I
L
V
T
L
V
H
A
M
Q
K
R
D
A
K
K
G
L
A
T
L
C
I
G
G
G
Q
G
T
A
I
L
L
E
K
C
26
PsiBlast_CBE
94.41
51%
-80
- C4 -
4O99
1
THIL_CUPNH
B:
[2-391]
--
D
V
V
I
V
S
A
A
R
T
A
V
G
K
F
G
G
S
L
A
K
I
P
A
P
E
L
G
A
V
V
I
K
A
A
L
E
R
A
G
V
K
P
E
----
Q
V
S
E
V
I
M
G
Q
V
L
T
A
G
-
S
G
Q
N
P
A
R
Q
A
A
I
K
A
G
L
P
A
M
V
P
A
M
T
I
N
K
V
C
G
S
G
L
K
A
V
M
L
A
A
N
A
I
M
A
G
D
A
E
I
V
V
A
G
G
Q
E
N
M
S
A
A
P
H
V
L
P
G
S
R
D
G
F
R
M
G
D
A
K
L
V
D
T
M
I
V
D
G
L
W
D
V
Y
N
Q
Y
H
M
G
I
T
A
E
N
V
A
K
E
Y
G
I
T
R
E
A
Q
D
E
F
A
V
G
S
Q
N
K
A
E
A
A
Q
K
A
G
K
F
D
E
E
I
V
P
--
V
L
I
-
P
QRKG------
D
P
---
V
A
-
F
---
K
T
D
E
F
V
R
Q
G
A
T
L
D
S
M
S
G
L
K
P
A
F
-
D
--
K
A
-
G
T
V
T
A
A
N
A
S
G
L
N
D
G
A
A
A
V
V
V
M
S
A
A
K
A
K
E
L
G
L
T
P
L
A
T
I
K
S
Y
A
N
A
G
V
D
P
K
V
M
G
M
G
P
V
P
A
S
K
R
A
L
S
R
A
E
W
T
P
Q
D
L
D
L
M
E
I
N
E
A
F
A
A
Q
A
L
A
V
H
Q
Q
M
G
W
D
T
S
K
V
N
V
N
G
G
A
I
A
I
G
H
P
I
G
A
S
G
C
R
I
L
V
T
L
L
H
E
M
K
R
R
D
A
K
K
G
L
A
S
L
C
I
G
G
G
M
G
V
A
L
A
V
E
R
-
6
PsiBlast_PDB
94.10
51%
-80
- C4 -
4O9A
-
THIL_CUPNH
A:
[8-397]
--
D
V
V
I
V
S
A
A
R
T
A
V
G
K
F
G
G
S
L
A
K
I
P
A
P
E
L
G
A
V
V
I
K
A
A
L
E
R
A
G
V
K
P
E
----
Q
V
S
E
V
I
M
G
Q
V
L
T
A
G
-
S
G
Q
N
P
A
R
Q
A
A
I
K
A
G
L
P
A
M
V
P
A
M
T
I
N
K
V
S
G
S
G
L
K
A
V
M
L
A
A
N
A
I
M
A
G
D
A
E
I
V
V
A
G
G
Q
E
N
M
S
A
A
P
H
V
L
P
G
S
R
D
G
F
R
M
G
D
A
K
L
V
D
T
M
I
V
D
G
L
W
D
V
Y
N
Q
Y
H
M
G
I
T
A
E
N
V
A
K
E
Y
G
I
T
R
E
A
Q
D
E
F
A
V
G
S
Q
N
K
A
E
A
A
Q
K
A
G
K
F
D
E
E
I
V
P
--
V
L
I
-
P
Q
RK
G
------
D
P
---
V
A
-
F
---
K
T
D
E
F
V
R
Q
G
A
T
L
D
S
M
S
G
L
K
P
A
F
-
D
--
K
A
-
G
T
V
T
A
A
N
A
S
G
L
N
D
G
A
A
A
V
V
V
M
S
A
A
K
A
K
E
L
G
L
T
P
L
A
T
I
K
S
Y
A
N
A
G
V
D
P
K
V
M
G
M
G
P
V
P
A
S
K
R
A
L
S
R
A
E
W
T
P
Q
D
L
D
L
M
E
I
N
E
A
F
A
A
Q
A
L
A
V
H
Q
Q
M
G
W
D
T
S
K
V
N
V
N
G
G
A
I
A
I
G
H
P
I
G
A
S
G
C
R
I
L
V
T
L
L
H
E
M
K
R
R
D
A
K
K
G
L
A
S
L
C
I
G
G
G
M
G
V
A
L
A
V
E
R
-
25
PsiBlast_CBE
93.87
51%
-80
- C4 -
4O99
1
THIL_CUPNH
C:
[2-391]
--
D
V
V
I
V
S
A
A
R
T
A
V
G
K
F
G
G
S
L
A
K
I
P
A
P
E
L
G
A
V
V
I
K
A
A
L
E
R
A
G
V
K
P
E
----
Q
V
S
E
V
I
M
G
Q
V
L
T
A
G
-
S
G
Q
N
P
A
R
Q
A
A
I
K
A
G
L
P
A
M
V
P
A
M
T
I
N
K
V
C
G
S
G
L
K
A
V
M
L
A
A
N
A
I
M
A
G
D
A
E
I
V
V
A
G
G
Q
E
N
M
S
A
A
P
H
V
L
P
G
S
R
D
G
F
R
M
G
D
A
K
L
V
D
T
M
I
V
D
G
L
W
D
V
Y
N
Q
Y
H
M
G
I
T
A
E
N
V
A
K
E
Y
G
I
T
R
E
A
Q
D
E
F
A
V
G
S
Q
N
K
A
E
A
A
Q
K
A
G
K
F
D
E
E
I
V
P
--
V
L
I
-
P
QRKG------
D
P
---
V
A
-
F
---
K
T
D
E
F
V
R
Q
G
A
T
L
D
S
M
S
G
L
K
P
A
F
-
D
--
K
A
-
G
T
V
T
A
A
N
A
S
G
L
N
D
G
A
A
A
V
V
V
M
S
A
A
K
A
K
E
L
G
L
T
P
L
A
T
I
K
S
Y
A
N
A
G
V
D
P
K
V
M
G
M
G
P
V
P
A
S
K
R
A
L
S
R
A
E
W
T
P
Q
D
L
D
L
M
E
I
N
E
A
F
A
A
Q
A
L
A
V
H
Q
Q
M
G
W
D
T
S
K
V
N
V
N
G
G
A
I
A
I
G
H
P
I
G
A
S
G
C
R
I
L
V
T
L
L
H
E
M
K
R
R
D
A
K
K
G
L
A
S
L
C
I
G
G
G
M
G
V
A
L
A
V
E
R
-
5
PsiBlast_PDB
92.95
51%
-81
- C4 -
4O9C
-
THIL_CUPNH
A:
[1-392]
M
T
D
V
V
I
V
S
A
A
R
T
A
V
G
K
F
G
G
S
L
A
K
I
P
A
P
E
L
G
A
V
V
I
K
A
A
L
E
R
A
G
V
K
P
E
----
Q
V
S
E
V
I
M
G
Q
V
L
T
A
G
-
S
G
Q
N
P
A
R
Q
A
A
I
K
A
G
L
P
A
M
V
P
A
M
T
I
N
K
V
S
G
S
G
L
K
A
V
M
L
A
A
N
A
I
M
A
G
D
A
E
I
V
V
A
G
G
Q
E
N
M
S
A
A
P
H
V
L
P
G
S
R
D
G
F
R
M
G
D
A
K
L
V
D
T
M
I
V
D
G
L
W
D
V
Y
N
Q
Y
H
M
G
I
T
A
E
N
V
A
K
E
Y
G
I
T
R
E
A
Q
D
E
F
A
V
G
S
Q
N
K
A
E
A
A
Q
K
A
G
K
F
D
E
E
I
V
P
--
V
L
I
-
P
Q
RKG------
D
P
---
V
A
-
F
---
K
T
D
E
F
V
R
Q
G
A
T
L
D
S
M
S
G
L
K
P
A
F
-
D
--
K
A
-
G
T
V
T
A
A
N
A
S
G
L
N
D
G
A
A
A
V
V
V
M
S
A
A
K
A
K
E
L
G
L
T
P
L
A
T
I
K
S
Y
A
N
A
G
V
D
P
K
V
M
G
M
G
P
V
P
A
S
K
R
A
L
S
R
A
E
W
T
P
Q
D
L
D
L
M
E
I
N
E
A
F
A
A
Q
A
L
A
V
H
Q
Q
M
G
W
D
T
S
K
V
N
V
N
G
G
A
I
A
I
G
H
P
I
G
A
S
G
C
R
I
L
V
T
L
L
H
E
M
K
R
R
D
A
K
K
G
L
A
S
L
C
I
G
G
G
M
G
V
A
L
A
V
E
R
-
27
PsiBlast_CBE
92.87
51%
-80
- C4 -
4O9C
1
THIL_CUPNH
H:
[1-392]
M
T
D
V
V
I
V
S
A
A
R
T
A
V
G
K
F
G
G
S
L
A
K
I
P
A
P
E
L
G
A
V
V
I
K
A
A
L
E
R
A
G
V
K
P
E
----
Q
V
S
E
V
I
M
G
Q
V
L
T
A
G
-
S
G
Q
N
P
A
R
Q
A
A
I
K
A
G
L
P
A
M
V
P
A
M
T
I
N
K
V
S
G
S
G
L
K
A
V
M
L
A
A
N
A
I
M
A
G
D
A
E
I
V
V
A
G
G
Q
E
N
M
S
A
A
P
H
V
L
P
G
S
R
D
G
F
R
M
G
D
A
K
L
V
D
T
M
I
V
D
G
L
W
D
V
Y
N
Q
Y
H
M
G
I
T
A
E
N
V
A
K
E
Y
G
I
T
R
E
A
Q
D
E
F
A
V
G
S
Q
N
K
A
E
A
A
Q
K
A
G
K
F
D
E
E
I
V
P
--
V
L
I
-
P
QRKG------
D
P
---
V
A
-
F
---
K
T
D
E
F
V
R
Q
G
A
T
L
D
S
M
S
G
L
K
P
A
F
-
D
--
K
A
-
G
T
V
T
A
A
N
A
S
G
L
N
D
G
A
A
A
V
V
V
M
S
A
A
K
A
K
E
L
G
L
T
P
L
A
T
I
K
S
Y
A
N
A
G
V
D
P
K
V
M
G
M
G
P
V
P
A
S
K
R
A
L
S
R
A
E
W
T
P
Q
D
L
D
L
M
E
I
N
E
A
F
A
A
Q
A
L
A
V
H
Q
Q
M
G
W
D
T
S
K
V
N
V
N
G
G
A
I
A
I
G
H
P
I
G
A
S
G
C
R
I
L
V
T
L
L
H
E
M
K
R
R
D
A
K
K
G
L
A
S
L
C
I
G
G
G
M
G
V
A
L
A
V
E
R
-
21
PsiBlast_CBE
92.85
53%
-79
- C4 -
4N44
4
?
B:
[1-392]
M
K
E
V
V
I
A
S
A
V
R
T
A
I
G
S
Y
G
K
S
L
K
D
V
P
A
V
D
L
G
A
T
A
I
K
E
A
V
K
K
A
G
I
K
P
E
----
D
V
N
E
V
I
L
G
N
V
L
Q
A
G
-
L
G
Q
N
P
A
R
Q
A
S
F
K
A
G
L
P
V
E
I
P
A
M
T
I
N
K
V
C
G
S
G
L
R
T
V
S
L
A
A
Q
I
I
K
A
G
D
A
D
V
I
I
A
G
G
M
E
N
M
S
R
A
P
Y
L
A
N
N
A
R
W
G
Y
R
M
G
N
A
K
F
V
D
E
M
I
T
D
G
L
W
D
A
F
N
D
Y
H
M
G
I
T
A
E
N
I
A
E
R
W
N
I
S
R
E
E
Q
D
E
F
A
L
A
S
Q
K
K
A
E
E
A
I
K
S
G
Q
F
K
D
E
I
V
P
--
V
V
I
-
K
----------
G
R
KGE
T
V
-
V
---
D
T
D
E
H
P
R
F
G
S
T
I
E
G
L
A
K
L
K
P
A
F
-
K
--
K
D
-
G
T
V
T
A
G
N
A
S
G
L
N
D
C
A
A
V
L
V
I
M
S
A
E
K
A
K
E
L
G
V
K
P
L
A
K
I
V
S
Y
G
S
A
G
V
D
P
A
I
M
G
Y
G
P
F
Y
A
T
K
A
A
I
E
K
A
G
W
T
V
D
E
L
D
L
I
E
S
N
E
A
F
A
A
Q
S
L
A
V
A
K
D
L
K
F
D
M
N
K
V
N
V
N
G
G
A
I
A
L
G
H
P
I
G
A
S
G
A
R
I
L
V
T
L
V
H
A
M
Q
K
R
D
A
K
K
G
L
A
T
L
C
I
G
G
G
Q
G
T
A
I
L
L
E
K
C
28
PsiBlast_CBE
92.48
51%
-80
- C4 -
4O9C
1
THIL_CUPNH
C:
[1-392]
M
T
D
V
V
I
V
S
A
A
R
T
A
V
G
K
F
G
G
S
L
A
K
I
P
A
P
E
L
G
A
V
V
I
K
A
A
L
E
R
A
G
V
K
P
E
----
Q
V
S
E
V
I
M
G
Q
V
L
T
A
G
-
S
G
Q
N
P
A
R
Q
A
A
I
K
A
G
L
P
A
M
V
P
A
M
T
I
N
K
V
S
G
S
G
L
K
A
V
M
L
A
A
N
A
I
M
A
G
D
A
E
I
V
V
A
G
G
Q
E
N
M
S
A
A
P
H
V
L
P
G
S
R
D
G
F
R
M
G
D
A
K
L
V
D
T
M
I
V
D
G
L
W
D
V
Y
N
Q
Y
H
M
G
I
T
A
E
N
V
A
K
E
Y
G
I
T
R
E
A
Q
D
E
F
A
V
G
S
Q
N
K
A
E
A
A
Q
K
A
G
K
F
D
E
E
I
V
P
--
V
L
I
-
P
QRKG------
D
P
---
V
A
-
F
---
K
T
D
E
F
V
R
Q
G
A
T
L
D
S
M
S
G
L
K
P
A
F
-
D
--
K
A
-
G
T
V
T
A
A
N
A
S
G
L
N
D
G
A
A
A
V
V
V
M
S
A
A
K
A
K
E
L
G
L
T
P
L
A
T
I
K
S
Y
A
N
A
G
V
D
P
K
V
M
G
M
G
P
V
P
A
S
K
R
A
L
S
R
A
E
W
T
P
Q
D
L
D
L
M
E
I
N
E
A
F
A
A
Q
A
L
A
V
H
Q
Q
M
G
W
D
T
S
K
V
N
V
N
G
G
A
I
A
I
G
H
P
I
G
A
S
G
C
R
I
L
V
T
L
L
H
E
M
K
R
R
D
A
K
K
G
L
A
S
L
C
I
G
G
G
M
G
V
A
L
A
V
E
R
-
3
PsiBlast_PDB
92.45
52%
-80
- C4 -
4DD5
-
THLA_PEPD6
A:
[6-396]
M
R
E
V
V
I
A
S
A
A
R
T
A
V
G
S
F
G
G
A
F
K
S
V
S
A
V
E
L
G
V
T
A
A
K
E
A
I
K
R
A
N
I
T
P
D
----
M
I
D
E
S
L
L
G
G
V
L
T
A
G
-
L
G
Q
N
I
A
R
Q
I
A
L
G
A
G
I
P
V
E
K
P
A
M
T
I
N
I
V
C
G
S
G
L
R
S
V
S
M
A
S
Q
L
I
A
L
G
D
A
D
I
M
L
V
G
G
A
E
N
M
S
M
S
P
Y
L
V
P
S
A
R
Y
G
A
R
M
G
D
A
A
F
V
D
S
M
I
K
D
G
L
S
D
I
F
N
N
Y
H
M
G
I
T
A
E
N
I
A
E
Q
W
N
I
T
R
E
E
Q
D
E
L
A
L
A
S
Q
N
K
A
E
K
A
Q
A
E
G
K
F
D
E
E
I
V
P
--
V
V
I
K------------
D
---
T
V
-
V
---
D
K
D
E
Y
I
K
P
G
T
T
M
E
K
L
A
K
L
R
P
A
F
-
K
--
K
D
-
G
T
V
T
A
G
N
A
S
G
I
N
D
G
A
A
M
L
V
V
M
A
K
E
K
A
E
E
L
G
I
E
P
L
A
T
I
V
S
Y
G
T
A
G
V
D
P
K
I
M
G
Y
G
P
V
P
A
T
K
K
A
L
E
A
A
N
M
T
I
E
D
I
D
L
V
E
A
N
E
A
F
A
A
Q
S
V
A
V
I
R
D
L
N
I
D
M
N
K
V
N
V
N
G
G
A
I
A
I
G
H
P
I
G
C
S
G
A
R
I
L
T
T
L
L
Y
E
M
K
R
R
D
A
K
T
G
L
A
T
L
C
I
G
G
G
M
G
T
T
L
I
V
K
R
-
125
HHSearch
91.54
49%
-78
- C4 -
1WL4
7
THIC_HUMAN
A:
[5-396]
S
D
P
V
V
I
V
S
A
A
R
T
I
I
G
S
F
N
G
A
L
A
A
V
P
V
Q
D
L
G
S
T
V
I
K
E
V
L
K
R
A
T
V
A
P
E
----
D
V
S
E
V
I
F
G
H
V
L
A
A
G
-
C
G
Q
N
P
V
R
Q
A
S
V
G
A
G
I
P
Y
S
V
P
A
W
S
C
Q
M
I
C
G
S
G
L
K
A
V
C
L
A
V
Q
S
I
G
I
G
D
S
S
I
V
V
A
G
G
M
E
N
M
S
K
A
P
H
L
A
Y
L
R
T
-
G
V
K
I
G
E
M
P
L
T
D
S
I
L
C
D
G
L
T
D
A
F
H
N
C
H
M
G
I
T
A
E
N
V
A
K
K
W
Q
V
S
R
E
D
Q
D
K
V
A
V
L
S
Q
N
R
T
E
N
A
Q
K
A
G
H
F
D
K
E
I
V
P
--
V
L
V
-
S
----------
T
R
K
G
L
I
E
-
V
---
K
T
D
E
F
P
R
H
G
S
N
I
E
A
M
S
K
L
K
P
Y
F
-
L
TD
G
T
-
G
T
V
T
P
A
N
A
S
G
I
N
D
G
A
A
A
V
V
L
M
K
K
S
E
A
D
K
R
G
L
T
P
L
A
R
I
V
S
W
S
Q
V
G
V
E
P
S
I
M
G
I
G
P
I
P
A
I
K
Q
A
V
T
K
A
G
W
S
L
E
D
V
D
I
F
E
I
N
E
A
F
A
A
V
S
A
A
I
V
K
E
L
G
L
N
P
E
K
V
N
I
E
G
G
A
I
A
L
G
H
P
L
G
A
S
G
C
R
I
L
V
T
L
L
H
T
L
E
R
M
G
R
S
R
G
V
A
A
L
C
I
G
G
G
M
G
I
A
M
C
V
Q
R
-
7
PsiBlast_PDB
91.15
48%
-80
- C4 -
1WL4
7
THIC_HUMAN
A:
[8-396]
---
V
V
I
V
S
A
A
R
T
I
I
G
S
F
N
G
A
L
A
A
V
P
V
Q
D
L
G
S
T
V
I
K
E
V
L
K
R
A
T
V
A
P
E
----
D
V
S
E
V
I
F
G
H
V
L
A
A
G
-
C
G
Q
N
P
V
R
Q
A
S
V
G
A
G
I
P
Y
S
V
P
A
W
S
C
Q
M
I
C
G
S
G
L
K
A
V
C
L
A
V
Q
S
I
G
I
G
D
S
S
I
V
V
A
G
G
M
E
N
M
S
K
A
P
H
L
A
Y
L
R
-
T
G
V
K
I
G
E
M
P
L
T
D
S
I
L
C
D
G
L
T
D
A
F
H
N
C
H
M
G
I
T
A
E
N
V
A
K
K
W
Q
V
S
R
E
D
Q
D
K
V
A
V
L
S
Q
N
R
T
E
N
A
Q
K
A
G
H
F
D
K
E
I
V
P
--
V
L
V
-
S
----------
T
R
---
K
G
-
L
I
E
V
K
T
D
E
F
P
R
H
G
S
N
I
E
A
M
S
K
L
K
P
Y
F
L
T
--
D
G
T
G
T
V
T
P
A
N
A
S
G
I
N
D
G
A
A
A
V
V
L
M
K
K
S
E
A
D
K
R
G
L
T
P
L
A
R
I
V
S
W
S
Q
V
G
V
E
P
S
I
M
G
I
G
P
I
P
A
I
K
Q
A
V
T
K
A
G
W
S
L
E
D
V
D
I
F
E
I
N
E
A
F
A
A
V
S
A
A
I
V
K
E
L
G
L
N
P
E
K
V
N
I
E
G
G
A
I
A
L
G
H
P
L
G
A
S
G
C
R
I
L
V
T
L
L
H
T
L
E
R
M
G
R
S
R
G
V
A
A
L
C
I
G
G
G
M
G
I
A
M
C
V
Q
R
-
31
PsiBlast_CBE
90.93
47%
-81
- C4 -
1DLV
5
THIL_ZOORA
B:
[2-387]
---
I
V
I
A
S
A
A
R
T
A
V
G
S
F
N
G
A
F
A
N
T
P
A
H
E
L
G
A
T
V
I
S
A
V
L
E
R
A
G
V
A
A
G
----
E
V
N
E
V
I
L
G
Q
V
L
P
A
G
-
E
G
Q
N
P
A
R
Q
A
A
M
K
A
G
V
P
Q
E
A
T
A
W
G
M
N
Q
L
C
G
S
G
L
R
A
V
A
L
G
M
Q
Q
I
A
T
G
D
A
S
I
I
V
A
G
G
M
E
S
M
S
M
A
P
H
C
A
H
L
R
-
G
G
V
K
M
G
D
F
K
M
I
D
T
M
I
K
D
G
L
T
D
A
F
Y
G
Y
H
M
G
T
T
A
E
N
V
A
K
Q
W
Q
L
S
R
D
E
Q
D
A
F
A
V
A
S
Q
N
K
A
E
A
A
Q
K
D
G
R
F
K
D
E
I
V
P
FI
V
K
G
-
R
----------
K
G
---
D
I
T
V
---
D
A
D
E
Y
I
R
H
G
A
T
L
D
S
M
A
K
L
R
P
A
F
-
D
--
K
E
-
G
T
V
T
A
G
N
A
S
G
L
N
D
G
A
A
A
A
L
L
M
S
E
A
E
A
S
R
R
G
I
Q
P
L
G
R
I
V
S
W
A
T
V
G
V
D
P
K
V
M
G
T
G
P
I
P
A
S
R
K
A
L
E
R
A
G
W
K
I
G
D
L
D
L
V
E
A
N
E
A
F
A
A
Q
A
C
A
V
N
K
D
L
G
W
D
P
S
I
V
N
V
N
G
G
A
I
A
I
G
H
P
I
G
A
S
G
A
R
I
L
N
T
L
L
F
E
M
K
R
R
G
A
R
K
G
L
A
T
L
C
I
G
G
G
M
G
V
A
M
C
I
E
--
29
PsiBlast_CBE
90.84
47%
-81
- C4 -
1DLV
2
THIL_ZOORA
D:
[2-387]
---
I
V
I
A
S
A
A
R
T
A
V
G
S
F
N
G
A
F
A
N
T
P
A
H
E
L
G
A
T
V
I
S
A
V
L
E
R
A
G
V
A
A
G
----
E
V
N
E
V
I
L
G
Q
V
L
P
A
G
-
E
G
Q
N
P
A
R
Q
A
A
M
K
A
G
V
P
Q
E
A
T
A
W
G
M
N
Q
L
C
G
S
G
L
R
A
V
A
L
G
M
Q
Q
I
A
T
G
D
A
S
I
I
V
A
G
G
M
E
S
M
S
M
A
P
H
C
A
H
L
R
-
G
G
V
K
M
G
D
F
K
M
I
D
T
M
I
K
D
G
L
T
D
A
F
Y
G
Y
H
M
G
T
T
A
E
N
V
A
K
Q
W
Q
L
S
R
D
E
Q
D
A
F
A
V
A
S
Q
N
K
A
E
A
A
Q
K
D
G
R
F
K
D
E
I
V
P
FI
V
K
G
-
R
----------
K
G
---
D
I
T
V
---
D
A
D
E
Y
I
R
H
G
A
T
L
D
S
M
A
K
L
R
P
A
F
-
D
--
K
E
-
G
T
V
T
A
G
N
A
S
G
L
N
D
G
A
A
A
A
L
L
M
S
E
A
E
A
S
R
R
G
I
Q
P
L
G
R
I
V
S
W
A
T
V
G
V
D
P
K
V
M
G
T
G
P
I
P
A
S
R
K
A
L
E
R
A
G
W
K
I
G
D
L
D
L
V
E
A
N
E
A
F
A
A
Q
A
C
A
V
N
K
D
L
G
W
D
P
S
I
V
N
V
N
G
G
A
I
A
I
G
H
P
I
G
A
S
G
A
R
I
L
N
T
L
L
F
E
M
K
R
R
G
A
R
K
G
L
A
T
L
C
I
G
G
G
M
G
V
A
M
C
I
E
--
34
PsiBlast_CBE
90.64
47%
-81
- C4 -
1DLU
4
THIL_ZOORA
B:
[2-387]
---
I
V
I
A
S
A
A
R
T
A
V
G
S
F
N
G
A
F
A
N
T
P
A
H
E
L
G
A
T
V
I
S
A
V
L
E
R
A
G
V
A
A
G
----
E
V
N
E
V
I
L
G
Q
V
L
P
A
G
-
E
G
Q
N
P
A
R
Q
A
A
M
K
A
G
V
P
Q
E
A
T
A
W
G
M
N
Q
L
C
G
S
G
L
R
A
V
A
L
G
M
Q
Q
I
A
T
G
D
A
S
I
I
V
A
G
G
M
E
S
M
S
M
A
P
H
C
A
H
L
R
-
G
G
V
K
M
G
D
F
K
M
I
D
T
M
I
K
D
G
L
T
D
A
F
Y
G
Y
H
M
G
T
T
A
E
N
V
A
K
Q
W
Q
L
S
R
D
E
Q
D
A
F
A
V
A
S
Q
N
K
A
E
A
A
Q
K
D
G
R
F
K
D
E
I
V
P
FI
V
K
G
-
R
----------
K
G
---
D
I
T
V
---
D
A
D
E
Y
I
R
H
G
A
T
L
D
S
M
A
K
L
R
P
A
F
-
D
--
K
E
-
G
T
V
T
A
G
N
A
S
G
L
N
D
G
A
A
A
A
L
L
M
S
E
A
E
A
S
R
R
G
I
Q
P
L
G
R
I
V
S
W
A
T
V
G
V
D
P
K
V
M
G
T
G
P
I
P
A
S
R
K
A
L
E
R
A
G
W
K
I
G
D
L
D
L
V
E
A
N
E
A
F
A
A
Q
A
C
A
V
N
K
D
L
G
W
D
P
S
I
V
N
V
N
G
G
A
I
A
I
G
H
P
I
G
A
S
G
A
R
I
L
N
T
L
L
F
E
M
K
R
R
G
A
R
K
G
L
A
T
L
C
I
G
G
G
M
G
V
A
M
C
I
E
--
8
PsiBlast_PDB
90.63
48%
-79
- C4 -
1WL5
5
THIC_HUMAN
A:
[8-396]
---
V
V
I
V
S
A
A
R
T
I
I
G
S
F
N
G
A
L
A
A
V
P
V
Q
D
L
G
S
T
V
I
K
E
V
L
K
R
A
T
V
A
P
E
----
D
V
S
E
V
I
F
G
H
V
L
A
A
G
-
C
G
Q
N
P
V
R
Q
A
S
V
G
A
G
I
P
Y
S
V
P
A
W
S
C
Q
M
I
C
G
S
G
L
K
A
V
C
L
A
V
Q
S
I
G
I
G
D
S
S
I
V
V
A
G
G
M
E
N
M
S
K
A
P
H
L
A
Y
L
R
-
T
G
V
K
I
G
E
M
P
L
T
D
S
I
L
C
D
G
L
T
D
A
F
H
N
C
H
M
G
I
T
A
E
N
V
A
K
K
W
Q
V
S
R
E
D
Q
D
K
V
A
V
L
S
Q
N
R
T
E
N
A
Q
K
A
G
H
F
D
K
E
I
V
P
--
V
L
V
-
S
----------
T
R
---
K
G
-
L
I
E
V
K
T
D
E
F
P
R
H
G
S
N
I
E
A
M
S
K
L
K
P
Y
F
L
T
--
D
G
T
G
T
V
T
P
A
N
A
S
G
I
N
D
G
A
A
A
V
V
L
M
K
K
S
E
A
D
K
R
G
L
T
P
L
A
R
I
V
S
W
S
Q
V
G
V
E
P
S
I
M
G
I
G
P
I
P
A
I
K
Q
A
V
T
K
A
G
W
S
L
E
D
V
D
I
F
E
I
N
E
A
F
A
A
V
S
A
A
I
V
K
E
L
G
L
N
P
E
K
V
N
I
E
G
G
A
I
A
L
G
H
P
L
G
A
S
G
C
R
I
L
V
T
L
L
H
T
L
E
R
M
G
R
S
R
G
V
A
A
L
C
I
G
G
G
M
G
I
A
M
C
V
Q
R
-
47
PsiBlast_CBE
90.60
47%
-82
- C4 -
2VTZ
5
THIL_ZOORA
B:
[5-390]
---
I
V
I
A
S
A
A
R
T
A
V
G
S
F
N
G
A
F
A
N
T
P
A
H
E
L
G
A
T
V
I
S
A
V
L
E
R
A
G
V
A
A
G
----
E
V
N
E
V
I
L
G
Q
V
L
P
A
G
-
E
G
Q
N
P
A
R
Q
A
A
M
K
A
G
V
P
Q
E
A
T
A
W
G
M
N
Q
L
A
G
S
G
L
R
A
V
A
L
G
M
Q
Q
I
A
T
G
D
A
S
I
I
V
A
G
G
M
E
S
M
S
M
A
P
H
C
A
H
L
R
-
G
G
V
K
M
G
D
F
K
M
I
D
T
M
I
K
D
G
L
T
D
A
F
Y
G
Y
H
M
G
T
T
A
E
N
V
A
K
Q
W
Q
L
S
R
D
E
Q
D
A
F
A
V
A
S
Q
N
K
A
E
A
A
Q
K
D
G
R
F
K
D
E
I
V
P
FI
V
K
G
-
R
----------
K
G
---
D
I
T
V
---
D
A
D
E
Y
I
R
H
G
A
T
L
D
S
M
A
K
L
R
P
A
F
-
D
--
K
E
-
G
T
V
T
A
G
N
A
S
G
L
N
D
G
A
A
A
A
L
L
M
S
E
A
E
A
S
R
R
G
I
Q
P
L
G
R
I
V
S
W
A
T
V
G
V
D
P
K
V
M
G
T
G
P
I
P
A
S
R
K
A
L
E
R
A
G
W
K
I
G
D
L
D
L
V
E
A
N
E
A
F
A
A
Q
A
C
A
V
N
K
D
L
G
W
D
P
S
I
V
N
V
N
G
G
A
I
A
I
G
H
P
I
G
A
S
G
A
R
I
L
N
T
L
L
F
E
M
K
R
R
G
A
R
K
G
L
A
T
L
C
I
G
G
G
M
G
V
A
M
C
I
E
--
19
PsiBlast_PDB
90.39
47%
-82
- C4 -
1M3Z
4
THIL_ZOORA
A:
[5-390]
---
I
V
I
A
S
A
A
R
T
A
V
G
S
F
N
G
A
F
A
N
T
P
A
H
E
L
G
A
T
V
I
S
A
V
L
E
R
A
G
V
A
A
G
----
E
V
N
E
V
I
L
G
Q
V
L
P
A
G
-
E
G
Q
N
P
A
R
Q
A
A
M
K
A
G
V
P
Q
E
A
T
A
W
G
M
N
Q
L
A
G
S
G
L
R
A
V
A
L
G
M
Q
Q
I
A
T
G
D
A
S
I
I
V
A
G
G
M
E
S
M
S
M
A
P
H
C
A
H
L
R
-
G
G
V
K
M
G
D
F
K
M
I
D
T
M
I
K
D
G
L
T
D
A
F
Y
G
Y
H
M
G
T
T
A
E
N
V
A
K
Q
W
Q
L
S
R
D
E
Q
D
A
F
A
V
A
S
Q
N
K
A
E
A
A
Q
K
D
G
R
F
K
D
E
I
V
P
FI
V
K
G
-
R
----------
K
G
---
D
I
T
V
---
D
A
D
E
Y
I
R
H
G
A
T
L
D
S
M
A
K
L
R
P
A
F
-
D
--
K
E
-
G
T
V
T
A
G
N
A
S
G
L
N
D
G
A
A
A
A
L
L
M
S
E
A
E
A
S
R
R
G
I
Q
P
L
G
R
I
V
S
W
A
T
V
G
V
D
P
K
V
M
G
T
G
P
I
P
A
S
R
K
A
L
E
R
A
G
W
K
I
G
D
L
D
L
V
E
A
N
E
A
F
A
A
Q
A
C
A
V
N
K
D
L
G
W
D
P
S
I
V
N
V
N
G
G
A
I
A
I
G
H
P
I
G
A
S
G
A
R
I
L
N
T
L
L
F
E
M
K
R
R
G
A
R
K
G
L
A
T
L
C
I
G
G
G
M
G
V
A
M
C
I
E
--
9
PsiBlast_PDB
90.39
47%
-84
- C4 -
1DLU
4
THIL_ZOORA
A:
[2-387]
---
I
V
I
A
S
A
A
R
T
A
V
G
S
F
N
G
A
F
A
N
T
P
A
H
E
L
G
A
T
V
I
S
A
V
L
E
R
A
G
V
A
A
G
----
E
V
N
E
V
I
L
G
Q
V
L
P
A
G
-
E
G
Q
N
P
A
R
Q
A
A
M
K
A
G
V
P
Q
E
A
T
A
W
G
M
N
Q
L
C
G
S
G
L
R
A
V
A
L
G
M
Q
Q
I
A
T
G
D
A
S
I
I
V
A
G
G
M
E
S
M
S
M
A
P
H
C
A
H
L
R
-
G
G
V
K
M
G
D
F
K
M
I
D
T
M
I
K
D
G
L
T
D
A
F
Y
G
Y
H
M
G
T
T
A
E
N
V
A
K
Q
W
Q
L
S
R
D
E
Q
D
A
F
A
V
A
S
Q
N
K
A
E
A
A
Q
K
D
G
R
F
K
D
E
I
V
P
FI
V
K
G
-
R
----------
K
G
---
D
I
T
V
---
D
A
D
E
Y
I
R
H
G
A
T
L
D
S
M
A
K
L
R
P
A
F
-
D
--
K
E
-
G
T
V
T
A
G
N
A
S
G
L
N
D
G
A
A
A
A
L
L
M
S
E
A
E
A
S
R
R
G
I
Q
P
L
G
R
I
V
S
W
A
T
V
G
V
D
P
K
V
M
G
T
G
P
I
P
A
S
R
K
A
L
E
R
A
G
W
K
I
G
D
L
D
L
V
E
A
N
E
A
F
A
A
Q
A
C
A
V
N
K
D
L
G
W
D
P
S
I
V
N
V
N
G
G
A
I
A
I
G
H
P
I
G
A
S
G
A
R
I
L
N
T
L
L
F
E
M
K
R
R
G
A
R
K
G
L
A
T
L
C
I
G
G
G
M
G
V
A
M
C
I
E
--
93
PsiBlast_CBE
80.88
33%
-66
- C4 -
4UBV
14
?
B:
[13-398]
----
V
I
V
E
A
T
R
S
P
I
G
K
R
N
G
W
L
S
G
L
H
A
T
E
L
L
G
A
V
Q
K
A
V
V
D
K
A
G
I
Q
S
G
LHAG
D
V
E
Q
V
I
G
G
C
V
T
Q
F
G
E
Q
S
N
N
I
S
R
V
A
W
L
T
A
G
L
P
E
H
V
G
A
T
T
V
D
C
Q
-
G
S
G
Q
Q
A
N
H
L
I
A
G
L
I
A
A
G
A
I
D
V
G
I
A
C
G
I
E
A
M
S
R
V
G
L
G
A
N
---
A
G
P
D
---
R
S
L
I
R
A
Q
S
W
D
--
I
D
L
P
N
Q
F
E
---
A
A
E
R
I
A
K
R
R
G
I
T
R
E
D
V
D
V
F
G
L
E
S
Q
R
R
A
Q
R
A
W
A
E
G
R
F
D
R
E
I
S
P
--
I
Q
A
-
P
V
L
D
EQNQPTG
E
R
---
R
L
-
V
---
F
R
D
Q
G
L
R
-
E
T
T
M
A
G
L
G
E
L
K
P
V
L
----
E
G
-
G
I
H
T
A
G
T
S
S
Q
I
S
D
G
A
A
A
V
L
W
M
D
E
A
V
A
R
A
H
G
L
T
P
R
A
R
I
V
A
Q
A
L
V
G
A
E
P
Y
Y
H
L
D
G
P
V
Q
S
T
A
K
V
L
E
K
A
G
M
K
I
G
D
I
D
I
V
E
I
N
E
A
F
A
S
V
V
L
S
W
A
R
V
H
E
P
D
M
D
R
V
N
V
N
G
G
A
I
A
L
G
H
P
V
G
C
T
G
S
R
L
I
T
T
A
L
H
E
L
E
R
T
D
Q
S
L
A
L
I
T
M
C
A
G
G
A
L
S
T
G
T
I
I
E
R
-
92
PsiBlast_CBE
79.69
33%
-68
- C4 -
4UBW
21
?
A:
[13-398]
----
V
I
V
E
A
T
R
S
P
I
G
K
R
N
G
W
L
S
G
L
H
A
T
E
L
L
G
A
V
Q
K
A
V
V
D
K
A
G
I
Q
S
G
LHAG
D
V
E
Q
V
I
G
G
C
V
T
Q
F
G
E
Q
S
N
N
I
S
R
V
A
W
L
T
A
G
L
P
E
H
V
G
A
T
T
V
D
C
Q
C
G
S
G
Q
Q
A
N
H
L
I
A
G
L
I
A
A
G
A
I
D
V
G
I
A
C
G
I
E
A
M
S
R
V
G
L
G
A
N
---
A
G
P
D
---
R
------
S
W
D
--
I
D
L
P
N
Q
F
E
---
A
A
E
R
I
A
K
R
R
G
I
T
R
E
D
V
D
V
F
G
L
E
S
Q
R
R
A
Q
R
A
W
A
E
G
R
F
D
R
E
I
S
P
--
I
Q
A
-
P
V
L
D
EQNQPTG
E
R
---
R
L
-
V
---
F
R
D
Q
G
L
R
-
E
T
T
M
A
G
L
G
E
L
K
P
V
L
----
E
G
-
G
I
H
T
A
G
T
S
S
Q
I
S
D
G
A
A
A
V
L
W
M
D
E
A
V
A
R
A
H
G
L
T
P
R
A
R
I
V
A
Q
A
L
V
G
A
E
P
Y
Y
H
L
D
G
P
V
Q
S
T
A
K
V
L
E
K
A
G
M
K
I
G
D
I
D
I
V
E
I
N
E
A
F
A
S
V
V
L
S
W
A
R
V
H
E
P
D
M
D
R
V
N
V
N
G
G
A
I
A
L
G
H
P
V
G
C
T
G
S
R
L
I
T
T
A
L
H
E
L
E
R
T
D
Q
S
L
A
L
I
T
M
C
A
G
G
A
L
S
T
G
T
I
I
E
R
-