@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : Lmo1622: (2016-03-26 )
LKKITPKAMCAWIPKREDETHKGDYGRVLIVAGNKQFGGAAIMAAEACVKSGAGLTTVASDSVNRPALQTRIPECMFIDYENITSLSEQISQFDTILIGPGLGLDAYAEEIFRLVLQKSTEHQQVIIDGDGITIYAKGENPHPAAKLTFTPHAGEWERLKVLAPDAVTPTDVALAIDATIVLKGHRTKVYSGESAWQNMYGTPAMATGGMGDTLAGTICGLMAQTEKPITGTLAAVFLHSYIGEILAKKRYVVLPTEIAEELPTYLKIFSETDEHA
Atome Classification :
(20 SA)
.........10........20........30........40........50........60........70.....---------...80........90........100.......110.......-120.......130.......140-.--.--......150.......-160.-...--.---..170--..-..---.----...180.......190.......200.......210.......220..--...-..230.......240.......250.......260.......270....
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
LKKI
T
P
K
A
M
C
A
WIPKREDETHKGDY
G
R
V
L
I
V
AGNKQFG
G
A
A
I
M
A
A
E
A
C
V
KSGAG
L
T
T
VASDSVNR
P
A
L
Q
TRIP
E
C
M
---------
F
I
D
Y
E
N
I
T
S
L
S
E
Q
I
S
QF
D
T
I
L
IGPGLG
L
D
A
Y
A
E
E
I
F
R
L
V
L
QKS-TEH
Q
Q
V
I
IDGD
G
I
T
I
Y
AKGENP--H--P--
A
A
K
L
T
FTPHAG
E
W
E
R
L
-
K
V
LA-PDA--V---TPT
D
---
V
A
-
L
A
---
I
----
D
A
T
I
V
L
KGH
R
T
K
VYSG
E
S
A
W
Q
NMYGTPAMATGGMG
D
T
L
A
G
T
I
C
G
L
M
AQ--TEK-P
I
T
G
T
L
A
A
V
F
L
H
S
Y
I
G
E
I
L
AKK
R
Y
V
V
L
P
T
E
I
A
E
E
L
P
T
Y
L
K
I
F
SETDEHA
22
HHSearch
99.29
44%
-102
* C2 *
2R3B
7
NNRD_ENTFA
A:
[21-295]
-
R
Y
L
S
K
D
I
L
E
E
V
I
T
Q
R
P
S
D
S
Y
K
S
N
F
G
R
V
V
L
I
G
G
N
R
Q
Y
G
G
A
I
I
M
S
T
E
A
C
I
N
S
G
A
G
L
T
T
V
I
T
D
V
K
N
H
G
P
L
H
A
R
C
P
E
A
M
---------
V
V
G
F
E
E
T
V
L
L
T
N
V
V
E
Q
A
D
V
I
L
I
G
P
G
L
G
L
D
A
T
A
Q
Q
I
L
K
M
V
L
A
Q
H
-
Q
K
Q
Q
W
L
I
I
D
G
S
A
I
T
L
F
S
Q
G
N
F
S
L-
T
--
Y
--
P
E
K
V
V
F
T
P
H
Q
M
E
W
Q
R
L
-
S
H
L
P
-
I
E
Q
--
Q
T
L
A
N
N
Q
R
---
Q
Q
-
A
K
---
L
----
G
S
T
I
V
L
K
S
H
R
T
T
I
F
H
A
G
E
P
F
Q
N
T
G
G
N
P
G
M
A
T
G
G
T
G
D
T
L
A
G
I
I
A
G
F
L
A
Q
--
F
K
P
-
T
I
E
T
I
A
G
A
V
Y
L
H
S
L
I
G
D
D
L
A
K
T
D
Y
V
V
L
P
T
K
I
S
Q
A
L
P
T
Y
M
K
K
Y
A
Q
P
----
2
PsiBlast_PDB
94.18
44%
-105
- C2 -
2R3E
2
NNRD_ENTFA
A:
[32-294]
------------
I
T
Q
R
P
S
D
S
Y
K
S
N
F
G
R
V
V
L
I
G
G
N
R
Q
Y
G
G
A
I
I
M
S
T
E
A
C
I
N
S
G
A
G
L
T
T
V
I
T
D
V
K
N
H
G
P
L
H
A
R
C
P
E
A
M
---------
V
V
G
F
E
E
T
V
L
L
T
N
V
V
E
Q
A
D
V
I
L
I
G
P
G
L
G
L
D
A
T
A
Q
Q
I
L
K
M
V
L
A
Q
H
-
Q
K
Q
Q
W
L
I
I
D
G
S
A
I
T
L
F
S
Q
G
N
F
S
LT
Y
--
P
---
E
K
V
V
F
T
P
H
Q
M
E
W
Q
R
L
-
S
H
L
P
-
I
E
Q
--
Q
---
T
L
A
N
N
Q
R
Q
Q
-
A
K
---
L
----
G
S
T
I
V
L
K
S
H
R
T
T
I
F
H
A
G
E
P
F
Q
N
T
G
G
N
P
G
M
A
T
G
G
T
G
D
T
L
A
G
I
I
A
G
F
L
A
Q
--
F
K
P
-
T
I
E
T
I
A
G
A
V
Y
L
H
S
L
I
G
D
D
L
A
K
T
D
Y
V
V
L
P
T
K
I
S
Q
A
L
P
T
Y
M
K
K
Y
A
Q
-----
21
HHSearch
93.29
43%
-101
- C2 -
3BGK
2
?
A:
[36-311]
--
I
I
D
D
L
L
T
K
K
I
I
K
P
R
P
L
N
S
H
K
G
T
F
G
R
V
L
L
I
G
G
N
Y
P
Y
G
G
A
I
I
M
A
A
L
A
C
V
N
S
G
A
G
L
V
T
V
A
T
H
K
D
N
I
T
A
L
H
S
H
L
P
E
A
M
---------
A
F
D
M
V
E
K
D
R
L
S
E
Q
I
T
A
A
D
V
V
L
M
G
P
G
L
A
E
D
D
L
A
Q
-
T
T
F
D
V
V
W
Q
A
I
E
P
K
Q
T
L
I
I
D
G
S
A
I
N
L
L
A
K
R
K
-
A
-----
I
WP
T
K
Q
I
I
L
T
P
H
Q
K
E
W
E
R
L
-
S
G
L
T
-
I
P
E
QI
E
---
A
A
T
Q
---
T
A
L
A
H
---
F
PK--
E
T
I
L
V
A
K
S
H
Q
T
K
I
Y
Q
G
Q
K
I
G
H
I
Q
V
G
G
P
Y
Q
A
T
G
G
M
G
D
T
L
A
G
M
I
A
G
F
V
A
Q
--
F
H
T
D
R
F
E
V
A
A
A
A
V
F
L
H
S
Y
I
A
D
Q
L
S
K
E
A
Y
V
V
L
P
T
R
I
S
A
E
I
T
R
V
M
K
E
M
S
E
-----
1
PsiBlast_PDB
92.86
44%
-100
- C2 -
2R3B
7
NNRD_ENTFA
A:
[32-294]
------------
I
T
Q
R
P
S
D
S
Y
K
S
N
F
G
R
V
V
L
I
G
G
N
R
Q
Y
G
G
A
I
I
M
S
T
E
A
C
I
N
S
G
A
G
L
T
T
V
I
T
D
V
K
N
H
G
P
L
H
A
R
C
P
E
A
M
---------
V
V
G
F
E
E
T
V
L
L
T
N
V
V
E
Q
A
D
V
I
L
I
G
P
G
L
G
L
D
A
T
A
Q
Q
I
L
K
M
V
L
A
Q
H
-
Q
K
Q
Q
W
L
I
I
D
G
S
A
I
T
L
F
S
Q
G
N
F
S
LT
Y
--
P
---
E
K
V
V
F
T
P
H
Q
M
E
W
Q
R
L
-
S
H
L
P
-
I
E
Q
--
Q
---
T
L
A
N
N
Q
R
Q
Q
-
A
K
---
L
----
G
S
T
I
V
L
K
S
H
R
T
T
I
F
H
A
G
E
P
F
Q
N
T
G
G
N
P
G
M
A
T
G
G
T
G
D
T
L
A
G
I
I
A
G
F
L
A
Q
--
F
K
P
-
T
I
E
T
I
A
G
A
V
Y
L
H
S
L
I
G
D
D
L
A
K
T
D
Y
V
V
L
P
T
K
I
S
Q
A
L
P
T
Y
M
K
K
Y
A
Q
-----
3
PsiBlast_PDB
91.54
44%
-92
- C2 -
3BGK
2
?
A:
[46-311]
------------
I
K
P
R
P
L
N
S
H
K
G
T
F
G
R
V
L
L
I
G
G
N
Y
P
Y
G
G
A
I
I
M
A
A
L
A
C
V
N
S
G
A
G
L
V
T
V
A
T
H
K
D
N
I
T
A
L
H
S
H
L
P
E
A
M
---------
A
F
D
M
V
E
K
D
R
L
S
E
Q
I
T
A
A
D
V
V
L
M
G
P
G
L
A
E
D
D
L
A
Q
T
T
F
D
V
V
W
Q
A
I
-
E
P
K
Q
T
L
I
I
D
G
S
A
I
N
L
L
A
K
-
R
K
---
A
IW
P
--
T
K
Q
I
I
L
T
P
H
Q
K
E
W
E
R
L
-
S
G
L
T
I
P
E
Q
--
I
E
--
A
A
T
Q
---
T
A
-
L
A
HFP
K
----
E
T
I
L
V
A
K
S
H
Q
T
K
I
Y
Q
G
Q
K
I
G
H
I
Q
V
G
G
P
Y
Q
A
T
G
G
M
G
D
T
L
A
G
M
I
A
G
F
V
A
Q
FH
T
D
R
--
F
E
V
A
A
A
A
V
F
L
H
S
Y
I
A
D
Q
L
S
K
E
A
Y
V
V
L
P
T
R
I
S
A
E
I
T
R
V
M
K
E
M
S
E
-----
18
PsiBlast_PDB
78.74
28%
-101
- C2 -
3RRB
2
NNR_THEMA
A:
[223-501]
---
I
T
R
E
M
V
R
S
L
L
P
E
R
P
R
D
S
H
K
G
T
Y
G
K
V
L
I
I
A
G
S
R
L
Y
S
G
A
P
V
L
S
G
M
G
S
L
K
V
G
T
G
L
V
K
L
A
V
P
F
P
Q
N
L
I
A
T
S
R
F
P
E
L
I
S
V
P
I
D
T
EKG
F
F
S
L
Q
N
L
Q
E
C
L
E
L
S
K
D
V
D
V
V
A
I
G
P
G
L
G
N
N
E
H
V
R
E
F
V
N
E
F
L
K
---
T
L
E
K
P
A
V
I
D
A
D
A
I
N
V
L
D
T
S
V
L
K
--
E
--
R
--
K
S
P
A
V
L
T
P
H
P
G
E
M
A
R
L
V
K
K
T
V
-
G
D
V
--
K
---
Y
N
Y
E
---
L
A
-
E
E
---
F
A
K
E
N
D
C
V
L
V
L
K
S
A
T
T
I
V
T
D
G
E
K
T
L
F
N
I
T
G
N
T
G
L
S
K
G
G
S
G
D
V
L
T
G
M
I
A
G
F
I
A
Q
--
G
L
S
-
P
L
E
A
S
T
V
S
V
Y
L
H
G
F
A
A
E
L
F
E
Q
D
E
R
G
L
T
A
S
E
L
L
R
L
I
P
E
A
I
R
R
L
K
------
9
PsiBlast_PDB
78.70
28%
-100
- C2 -
3RSS
-
NNR_THEMA
A:
[223-501]
---
I
T
R
E
M
V
R
S
L
L
P
E
R
P
R
D
S
H
K
G
T
Y
G
K
V
L
I
I
A
G
S
R
L
Y
S
G
A
P
V
L
S
G
M
G
S
L
K
V
G
T
G
L
V
K
L
A
V
P
F
P
Q
N
L
I
A
T
S
R
F
P
E
L
I
S
V
P
I
D
T
EKG
F
F
S
L
Q
N
L
Q
E
C
L
E
L
S
K
D
V
D
V
V
A
I
G
P
G
L
G
N
N
E
H
V
R
E
F
V
N
E
F
L
K
---
T
L
E
K
P
A
V
I
D
A
D
A
I
N
V
L
D
T
S
V
L
K
--
E
--
R
--
K
S
P
A
V
L
T
P
H
P
G
E
M
A
R
L
V
K
K
T
V
-
G
D
V
--
K
---
Y
N
Y
E
---
L
A
-
E
E
---
F
A
K
E
N
D
C
V
L
V
L
K
S
A
T
T
I
V
T
D
G
E
K
T
L
F
N
I
T
G
N
T
G
L
S
K
G
G
S
G
D
V
L
T
G
M
I
A
G
F
I
A
Q
--
G
L
S
-
P
L
E
A
S
T
V
S
V
Y
L
H
G
F
A
A
E
L
F
E
Q
D
E
R
G
L
T
A
S
E
L
L
R
L
I
P
E
A
I
R
R
L
K
------
4
PsiBlast_PDB
78.45
28%
-97
- C2 -
2AX3
1
NNR_THEMA
A:
[223-501]
---
I
T
R
E
M
V
R
S
L
L
P
E
R
P
R
D
S
H
K
G
T
Y
G
K
V
L
I
I
A
G
S
R
L
Y
S
G
A
P
V
L
S
G
M
G
S
L
K
V
G
T
G
L
V
K
L
A
V
P
F
P
Q
N
L
I
A
T
S
R
F
P
E
L
I
S
V
P
I
D
T
EKG
F
F
S
L
Q
N
L
Q
E
C
L
E
L
S
K
D
V
D
V
V
A
I
G
P
G
L
G
N
N
E
H
V
R
E
F
V
N
E
F
L
K
---
T
L
E
K
P
A
V
I
D
A
D
A
I
N
V
L
D
T
S
V
L
K
--
E
--
R
--
K
S
P
A
V
L
T
P
H
P
G
E
M
A
R
L
V
K
K
T
V
-
G
D
V
--
K
---
Y
N
Y
E
---
L
A
-
E
E
---
F
A
K
E
N
D
C
V
L
V
L
K
S
A
T
T
I
V
T
D
G
E
K
T
L
F
N
I
T
G
N
T
G
L
S
K
G
G
S
G
D
V
L
T
G
M
I
A
G
F
I
A
Q
--
G
L
S
-
P
L
E
A
S
T
V
S
V
Y
L
H
G
F
A
A
E
L
F
E
Q
D
E
R
G
L
T
A
S
E
L
L
R
L
I
P
E
A
I
R
R
L
K
------
15
PsiBlast_PDB
78.30
28%
-100
- C2 -
3RTE
3
NNR_THEMA
A:
[223-501]
---
I
T
R
E
M
V
R
S
L
L
P
E
R
P
R
D
S
H
K
G
T
Y
G
K
V
L
I
I
A
G
S
R
L
Y
S
G
A
P
V
L
S
G
M
G
S
L
K
V
G
T
G
L
V
K
L
A
V
P
F
P
Q
N
L
I
A
T
S
R
F
P
E
L
I
S
V
P
I
D
T
EKG
F
F
S
L
Q
N
L
Q
E
C
L
E
L
S
K
D
V
D
V
V
A
I
G
P
G
L
G
N
N
E
H
V
R
E
F
V
N
E
F
L
K
---
T
L
E
K
P
A
V
I
D
A
D
A
I
N
V
L
D
T
S
V
L
K
--
E
--
R
--
K
S
P
A
V
L
T
P
H
P
G
E
M
A
R
L
V
K
K
T
V
-
G
D
V
--
K
---
Y
N
Y
E
---
L
A
-
E
E
---
F
A
K
E
N
D
C
V
L
V
L
K
S
A
T
T
I
V
T
D
G
E
K
T
L
F
N
I
T
G
N
T
G
L
S
K
G
G
S
G
D
V
L
T
G
M
I
A
G
F
I
A
Q
--
G
L
S
-
P
L
E
A
S
T
V
S
V
Y
L
H
G
F
A
A
E
L
F
E
Q
D
E
R
G
L
T
A
S
E
L
L
R
L
I
P
E
A
I
R
R
L
K
------
17
PsiBlast_PDB
78.22
28%
-100
- C2 -
3RU3
2
NNR_THEMA
A:
[223-501]
---
I
T
R
E
M
V
R
S
L
L
P
E
R
P
R
D
S
H
K
G
T
Y
G
K
V
L
I
I
A
G
S
R
L
Y
S
G
A
P
V
L
S
G
M
G
S
L
K
V
G
T
G
L
V
K
L
A
V
P
F
P
Q
N
L
I
A
T
S
R
F
P
E
L
I
S
V
P
I
D
T
EKG
F
F
S
L
Q
N
L
Q
E
C
L
E
L
S
K
D
V
D
V
V
A
I
G
P
G
L
G
N
N
E
H
V
R
E
F
V
N
E
F
L
K
---
T
L
E
K
P
A
V
I
D
A
D
A
I
N
V
L
D
T
S
V
L
K
--
E
--
R
--
K
S
P
A
V
L
T
P
H
P
G
E
M
A
R
L
V
K
K
T
V
-
G
D
V
--
K
---
Y
N
Y
E
---
L
A
-
E
E
---
F
A
K
E
N
D
C
V
L
V
L
K
S
A
T
T
I
V
T
D
G
E
K
T
L
F
N
I
T
G
N
T
G
L
S
K
G
G
S
G
D
V
L
T
G
M
I
A
G
F
I
A
Q
--
G
L
S
-
P
L
E
A
S
T
V
S
V
Y
L
H
G
F
A
A
E
L
F
E
Q
D
E
R
G
L
T
A
S
E
L
L
R
L
I
P
E
A
I
R
R
L
K
------
8
PsiBlast_PDB
78.20
28%
-100
- C2 -
3RSQ
1
NNR_THEMA
A:
[223-501]
---
I
T
R
E
M
V
R
S
L
L
P
E
R
P
R
D
S
H
K
G
T
Y
G
K
V
L
I
I
A
G
S
R
L
Y
S
G
A
P
V
L
S
G
M
G
S
L
K
V
G
T
G
L
V
K
L
A
V
P
F
P
Q
N
L
I
A
T
S
R
F
P
E
L
I
S
V
P
I
D
T
EKG
F
F
S
L
Q
N
L
Q
E
C
L
E
L
S
K
D
V
D
V
V
A
I
G
P
G
L
G
N
N
E
H
V
R
E
F
V
N
E
F
L
K
---
T
L
E
K
P
A
V
I
D
A
D
A
I
N
V
L
D
T
S
V
L
K
--
E
--
R
--
K
S
P
A
V
L
T
P
H
P
G
E
M
A
R
L
V
K
K
T
V
-
G
D
V
--
K
---
Y
N
Y
E
---
L
A
-
E
E
---
F
A
K
E
N
D
C
V
L
V
L
K
S
A
T
T
I
V
T
D
G
E
K
T
L
F
N
I
T
G
N
T
G
L
S
K
G
G
S
G
D
V
L
T
G
M
I
A
G
F
I
A
Q
--
G
L
S
-
P
L
E
A
S
T
V
S
V
Y
L
H
G
F
A
A
E
L
F
E
Q
D
E
R
G
L
T
A
S
E
L
L
R
L
I
P
E
A
I
R
R
L
K
------
7
PsiBlast_PDB
78.10
28%
-100
- C2 -
3RSF
-
NNR_THEMA
A:
[223-501]
---
I
T
R
E
M
V
R
S
L
L
P
E
R
P
R
D
S
H
K
G
T
Y
G
K
V
L
I
I
A
G
S
R
L
Y
S
G
A
P
V
L
S
G
M
G
S
L
K
V
G
T
G
L
V
K
L
A
V
P
F
P
Q
N
L
I
A
T
S
R
F
P
E
L
I
S
V
P
I
D
T
EKG
F
F
S
L
Q
N
L
Q
E
C
L
E
L
S
K
D
V
D
V
V
A
I
G
P
G
L
G
N
N
E
H
V
R
E
F
V
N
E
F
L
K
---
T
L
E
K
P
A
V
I
D
A
D
A
I
N
V
L
D
T
S
V
L
K
--
E
--
R
--
K
S
P
A
V
L
T
P
H
P
G
E
M
A
R
L
V
K
K
T
V
-
G
D
V
--
K
---
Y
N
Y
E
---
L
A
-
E
E
---
F
A
K
E
N
D
C
V
L
V
L
K
S
A
T
T
I
V
T
D
G
E
K
T
L
F
N
I
T
G
N
T
G
L
S
K
G
G
S
G
D
V
L
T
G
M
I
A
G
F
I
A
Q
--
G
L
S
-
P
L
E
A
S
T
V
S
V
Y
L
H
G
F
A
A
E
L
F
E
Q
D
E
R
G
L
T
A
S
E
L
L
R
L
I
P
E
A
I
R
R
L
K
------
12
PsiBlast_PDB
77.79
28%
-101
- C2 -
3RTA
1
NNR_THEMA
A:
[223-501]
---
I
T
R
E
M
V
R
S
L
L
P
E
R
P
R
D
S
H
K
G
T
Y
G
K
V
L
I
I
A
G
S
R
L
Y
S
G
A
P
V
L
S
G
M
G
S
L
K
V
G
T
G
L
V
K
L
A
V
P
F
P
Q
N
L
I
A
T
S
R
F
P
E
L
I
S
V
P
I
D
T
EKG
F
F
S
L
Q
N
L
Q
E
C
L
E
L
S
K
D
V
D
V
V
A
I
G
P
G
L
G
N
N
E
H
V
R
E
F
V
N
E
F
L
K
---
T
L
E
K
P
A
V
I
D
A
D
A
I
N
V
L
D
T
S
V
L
K
--
E
--
R
--
K
S
P
A
V
L
T
P
H
P
G
E
M
A
R
L
V
K
K
T
V
-
G
D
V
--
K
---
Y
N
Y
E
---
L
A
-
E
E
---
F
A
K
E
N
D
C
V
L
V
L
K
S
A
T
T
I
V
T
D
G
E
K
T
L
F
N
I
T
G
N
T
G
L
S
K
G
G
S
G
D
V
L
T
G
M
I
A
G
F
I
A
Q
--
G
L
S
-
P
L
E
A
S
T
V
S
V
Y
L
H
G
F
A
A
E
L
F
E
Q
D
E
R
G
L
T
A
S
E
L
L
R
L
I
P
E
A
I
R
R
L
K
------
11
PsiBlast_PDB
77.68
28%
-98
- C2 -
3RT9
3
NNR_THEMA
A:
[223-501]
---
I
T
R
E
M
V
R
S
L
L
P
E
R
P
R
D
S
H
K
G
T
Y
G
K
V
L
I
I
A
G
S
R
L
Y
S
G
A
P
V
L
S
G
M
G
S
L
K
V
G
T
G
L
V
K
L
A
V
P
F
P
Q
N
L
I
A
T
S
R
F
P
E
L
I
S
V
P
I
D
T
EKG
F
F
S
L
Q
N
L
Q
E
C
L
E
L
S
K
D
V
D
V
V
A
I
G
P
G
L
G
N
N
E
H
V
R
E
F
V
N
E
F
L
K
---
T
L
E
K
P
A
V
I
D
A
D
A
I
N
V
L
D
T
S
V
L
K
--
E
--
R
--
K
S
P
A
V
L
T
P
H
P
G
E
M
A
R
L
V
K
K
T
V
-
G
D
V
--
K
---
Y
N
Y
E
---
L
A
-
E
E
---
F
A
K
E
N
D
C
V
L
V
L
K
S
A
T
T
I
V
T
D
G
E
K
T
L
F
N
I
T
G
N
T
G
L
S
K
G
G
S
G
D
V
L
T
G
M
I
A
G
F
I
A
Q
--
G
L
S
-
P
L
E
A
S
T
V
S
V
Y
L
H
G
F
A
A
E
L
F
E
Q
D
E
R
G
L
T
A
S
E
L
L
R
L
I
P
E
A
I
R
R
L
K
------
10
PsiBlast_PDB
77.64
28%
-98
- C2 -
3RT7
3
NNR_THEMA
A:
[223-501]
---
I
T
R
E
M
V
R
S
L
L
P
E
R
P
R
D
S
H
K
G
T
Y
G
K
V
L
I
I
A
G
S
R
L
Y
S
G
A
P
V
L
S
G
M
G
S
L
K
V
G
T
G
L
V
K
L
A
V
P
F
P
Q
N
L
I
A
T
S
R
F
P
E
L
I
S
V
P
I
D
T
EKG
F
F
S
L
Q
N
L
Q
E
C
L
E
L
S
K
D
V
D
V
V
A
I
G
P
G
L
G
N
N
E
H
V
R
E
F
V
N
E
F
L
K
---
T
L
E
K
P
A
V
I
D
A
D
A
I
N
V
L
D
T
S
V
L
K
--
E
--
R
--
K
S
P
A
V
L
T
P
H
P
G
E
M
A
R
L
V
K
K
T
V
-
G
D
V
--
K
---
Y
N
Y
E
---
L
A
-
E
E
---
F
A
K
E
N
D
C
V
L
V
L
K
S
A
T
T
I
V
T
D
G
E
K
T
L
F
N
I
T
G
N
T
G
L
S
K
G
G
S
G
D
V
L
T
G
M
I
A
G
F
I
A
Q
--
G
L
S
-
P
L
E
A
S
T
V
S
V
Y
L
H
G
F
A
A
E
L
F
E
Q
D
E
R
G
L
T
A
S
E
L
L
R
L
I
P
E
A
I
R
R
L
K
------
16
PsiBlast_PDB
77.58
28%
-99
- C2 -
3RTG
4
NNR_THEMA
A:
[223-501]
---
I
T
R
E
M
V
R
S
L
L
P
E
R
P
R
D
S
H
K
G
T
Y
G
K
V
L
I
I
A
G
S
R
L
Y
S
G
A
P
V
L
S
G
M
G
S
L
K
V
G
T
G
L
V
K
L
A
V
P
F
P
Q
N
L
I
A
T
S
R
F
P
E
L
I
S
V
P
I
D
T
EKG
F
F
S
L
Q
N
L
Q
E
C
L
E
L
S
K
D
V
D
V
V
A
I
G
P
G
L
G
N
N
E
H
V
R
E
F
V
N
E
F
L
K
---
T
L
E
K
P
A
V
I
D
A
D
A
I
N
V
L
D
T
S
V
L
K
--
E
--
R
--
K
S
P
A
V
L
T
P
H
P
G
E
M
A
R
L
V
K
K
T
V
-
G
D
V
--
K
---
Y
N
Y
E
---
L
A
-
E
E
---
F
A
K
E
N
D
C
V
L
V
L
K
S
A
T
T
I
V
T
D
G
E
K
T
L
F
N
I
T
G
N
T
G
L
S
K
G
G
S
G
D
V
L
T
G
M
I
A
G
F
I
A
Q
--
G
L
S
-
P
L
E
A
S
T
V
S
V
Y
L
H
G
F
A
A
E
L
F
E
Q
D
E
R
G
L
T
A
S
E
L
L
R
L
I
P
E
A
I
R
R
L
K
------
13
PsiBlast_PDB
77.56
28%
-101
- C2 -
3RTC
3
NNR_THEMA
A:
[223-501]
---
I
T
R
E
M
V
R
S
L
L
P
E
R
P
R
D
S
H
K
G
T
Y
G
K
V
L
I
I
A
G
S
R
L
Y
S
G
A
P
V
L
S
G
M
G
S
L
K
V
G
T
G
L
V
K
L
A
V
P
F
P
Q
N
L
I
A
T
S
R
F
P
E
L
I
S
V
P
I
D
T
EKG
F
F
S
L
Q
N
L
Q
E
C
L
E
L
S
K
D
V
D
V
V
A
I
G
P
G
L
G
N
N
E
H
V
R
E
F
V
N
E
F
L
K
---
T
L
E
K
P
A
V
I
D
A
D
A
I
N
V
L
D
T
S
V
L
K
--
E
--
R
--
K
S
P
A
V
L
T
P
H
P
G
E
M
A
R
L
V
K
K
T
V
-
G
D
V
--
K
---
Y
N
Y
E
---
L
A
-
E
E
---
F
A
K
E
N
D
C
V
L
V
L
K
S
A
T
T
I
V
T
D
G
E
K
T
L
F
N
I
T
G
N
T
G
L
S
K
G
G
S
G
D
V
L
T
G
M
I
A
G
F
I
A
Q
--
G
L
S
-
P
L
E
A
S
T
V
S
V
Y
L
H
G
F
A
A
E
L
F
E
Q
D
E
R
G
L
T
A
S
E
L
L
R
L
I
P
E
A
I
R
R
L
K
------
6
PsiBlast_PDB
77.31
28%
-100
- C2 -
3RS9
2
NNR_THEMA
A:
[223-501]
---
I
T
R
E
M
V
R
S
L
L
P
E
R
P
R
D
S
H
K
G
T
Y
G
K
V
L
I
I
A
G
S
R
L
Y
S
G
A
P
V
L
S
G
M
G
S
L
K
V
G
T
G
L
V
K
L
A
V
P
F
P
Q
N
L
I
A
T
S
R
F
P
E
L
I
S
V
P
I
D
T
EKG
F
F
S
L
Q
N
L
Q
E
C
L
E
L
S
K
D
V
D
V
V
A
I
G
P
G
L
G
N
N
E
H
V
R
E
F
V
N
E
F
L
K
---
T
L
E
K
P
A
V
I
D
A
D
A
I
N
V
L
D
T
S
V
L
K
--
E
--
R
--
K
S
P
A
V
L
T
P
H
P
G
E
M
A
R
L
V
K
K
T
V
-
G
D
V
--
K
---
Y
N
Y
E
---
L
A
-
E
E
---
F
A
K
E
N
D
C
V
L
V
L
K
S
A
T
T
I
V
T
D
G
E
K
T
L
F
N
I
T
G
N
T
G
L
S
K
G
G
S
G
D
V
L
T
G
M
I
A
G
F
I
A
Q
--
G
L
S
-
P
L
E
A
S
T
V
S
V
Y
L
H
G
F
A
A
E
L
F
E
Q
D
E
R
G
L
T
A
S
E
L
L
R
L
I
P
E
A
I
R
R
L
K
------
14
PsiBlast_PDB
77.28
28%
-99
- C2 -
3RTD
3
NNR_THEMA
A:
[223-501]
---
I
T
R
E
M
V
R
S
L
L
P
E
R
P
R
D
S
H
K
G
T
Y
G
K
V
L
I
I
A
G
S
R
L
Y
S
G
A
P
V
L
S
G
M
G
S
L
K
V
G
T
G
L
V
K
L
A
V
P
F
P
Q
N
L
I
A
T
S
R
F
P
E
L
I
S
V
P
I
D
T
EKG
F
F
S
L
Q
N
L
Q
E
C
L
E
L
S
K
D
V
D
V
V
A
I
G
P
G
L
G
N
N
E
H
V
R
E
F
V
N
E
F
L
K
---
T
L
E
K
P
A
V
I
D
A
D
A
I
N
V
L
D
T
S
V
L
K
--
E
--
R
--
K
S
P
A
V
L
T
P
H
P
G
E
M
A
R
L
V
K
K
T
V
-
G
D
V
--
K
---
Y
N
Y
E
---
L
A
-
E
E
---
F
A
K
E
N
D
C
V
L
V
L
K
S
A
T
T
I
V
T
D
G
E
K
T
L
F
N
I
T
G
N
T
G
L
S
K
G
G
S
G
D
V
L
T
G
M
I
A
G
F
I
A
Q
--
G
L
S
-
P
L
E
A
S
T
V
S
V
Y
L
H
G
F
A
A
E
L
F
E
Q
D
E
R
G
L
T
A
S
E
L
L
R
L
I
P
E
A
I
R
R
L
K
------
5
PsiBlast_PDB
77.18
28%
-98
- C2 -
3RS8
4
NNR_THEMA
A:
[223-501]
---
I
T
R
E
M
V
R
S
L
L
P
E
R
P
R
D
S
H
K
G
T
Y
G
K
V
L
I
I
A
G
S
R
L
Y
S
G
A
P
V
L
S
G
M
G
S
L
K
V
G
T
G
L
V
K
L
A
V
P
F
P
Q
N
L
I
A
T
S
R
F
P
E
L
I
S
V
P
I
D
T
EKG
F
F
S
L
Q
N
L
Q
E
C
L
E
L
S
K
D
V
D
V
V
A
I
G
P
G
L
G
N
N
E
H
V
R
E
F
V
N
E
F
L
K
---
T
L
E
K
P
A
V
I
D
A
D
A
I
N
V
L
D
T
S
V
L
K
--
E
--
R
--
K
S
P
A
V
L
T
P
H
P
G
E
M
A
R
L
V
K
K
T
V
-
G
D
V
--
K
---
Y
N
Y
E
---
L
A
-
E
E
---
F
A
K
E
N
D
C
V
L
V
L
K
S
A
T
T
I
V
T
D
G
E
K
T
L
F
N
I
T
G
N
T
G
L
S
K
G
G
S
G
D
V
L
T
G
M
I
A
G
F
I
A
Q
--
G
L
S
-
P
L
E
A
S
T
V
S
V
Y
L
H
G
F
A
A
E
L
F
E
Q
D
E
R
G
L
T
A
S
E
L
L
R
L
I
P
E
A
I
R
R
L
K
------