@TOME V2.3
(Nov 2016)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : Lmo1675: (2016-03-27 )
MTNHEQVLTDYLAAFIEELVQAGVKEAIISPGSRSTPLALMMAEHPILKIYVDVDERSAGFFALGLAKASKRPVVLLCTSGTAAANYFPAVAEANLSQIPLIVLTADRPHELRNVGAPQAMDQLHLYGSHVKDFTDMALPENSEEMLRYAKWHGSRAVDIAMKTPRGPVHLNFPLREPLVPILEPSPFTATGKKHHHVHIYYTHEVLDDSSIQKMVTECTGKKGVFVVGPIDKKELEQPMVDLAKKLGWPILADPLSGLRSYGALDEVVIDQYDAFLKEAEIMDKLTPEVVIRFGSMPVSKPLKNWLEQLSDIRFYVVDPGAAWKDPIKAVTDMIHCDERFLLDIMQQNMPDDAKDAAWLSRWTSYNKVAREIVLAEMANTTILEEGKIVAELRRLLPEKAGLFIGNSMPIRDVDTYFSQIDKKIKMLANRGANGIDGVVSSALGASVVFQPMFLLIGDLSFYHDMNGLLMAKKYKMNLTIVIVNNDGGGIFSFLPQANEPKYFESLFGTSTELDFRFAAAFYDADYHETQSVDELEEAIDKASYHKGLDIIEVKTNRHENKANHQALWAKIADALKALN
Atome Classification :
(20 SA)
.........10........20........30........40........50........60........70........80........90........100.......110.....-..120.......130-.......140.......150.......160....-...170......-.180.......190--......-..200....-...210--.......-.-220.......230........240.......250.....-..260.-......270.......280....-.-..290.......300.......310.......320-........330......--.340......-.350.......360.......370.....-..380...-....390.......400----........410.......-420.......430------.......440.....-..--450-.---.......460.......470.......480.......490.......500.......510.......520.......530.......540.......550.......560.......570.......580
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MT
N
H
E
Q
V
L
T
D
Y
L
A
A
F
I
E
E
L
V
QA
G
V
K
E
A
IISPGSRST
P
L
A
L
M
MAEH
P
I
L
K
I
Y
V
D
VDERSA
G
F
F
A
L
GLAKASKR
P
V
V
L
L
CTSGTAAANYFPAVAEANLSQI
P
L
I
V
L
TADR
P
H
E
L
RNVGA-
P
Q
A
M
D
Q
L
H
L
Y
G
S
H
V
K
-
D
F
T
DMALPE
N
S
E
E
M
L
R
Y
A
K
WHGS
R
A
V
D
I
A
M
KTPR-G
P
V
H
LNFPLREP-LVPILEPSPFTAT---GKK
H
H
H
-
V
H
I
Y
Y
T
H
EV-LD
D
S
S
---
I
Q
K
M
V
T
E
-C-TGKK
G
V
F
V
VGP-I
D
K
K
E
L
E
Q
P
M
V
D
L
A
K
KLGWPILA
D
P
L
S
-
G
L
R
SYG-
A
L
D
E
V
V
I
D
Q
Y
D
A
F
L
K
E
A
E
I
M
D
KL-
T
-
P
E
V
V
I
R
FGSMP
V
S
K
P
L
K
N
W
L
E
Q
LSD
I
R
F
Y
V
VDPG--AAW
K
D
P
I
K
A
V
T
D
M
IHC
D
--
E
R
F
L
L
D
I
M
Q
Q-NMPD
D
A
K
D
A
A
W
L
S
R
WT
S
Y
N
K
V
A
R
E
I
V
L
A
E
-MAN
T
T
ILE-E
G
K
I
V
A
E
L
R
R
L
L
P
E
KA-----GLFIGNSMPI
R
D
V
D
T
Y
F
S
-
Q
I
D
K
K
I
K
M
L
A
NRG------AN
G
I
D
G
V
V
S
S
AL
G
A
S
-
V
V
--
F
-
Q
-
P
---
M
F
L
L
IG
D
L
S
F
Y
HDMN
G
L
L
M
A
K
K
Y
K
M
N
L
T
I
V
I
V
NNDGG
G
I
FSFLPQANE
P
K
Y
F
E
S
L
FGTST
E
L
D
F
R
F
A
A
A
F
YDADYHETQ
S
V
D
E
L
E
E
A
I
D
K
A
S
YHKG
L
D
I
I
E
V
KTNRHENKA
N
H
Q
A
L
W
A
K
I
A
D
A
L
K
ALN
40
HHSearch
98.23
97%
-114
- C7 -
3LQ1
-
MEND_LISMF
A:
[3-555]
--
N
H
E
Q
V
L
T
D
Y
L
A
A
F
I
E
E
L
V
Q
A
G
V
K
E
A
I
I
S
P
G
S
R
S
T
P
L
A
L
M
M
A
E
H
P
I
L
K
I
Y
V
D
V
D
E
R
S
A
G
F
F
A
L
G
L
A
K
A
S
K
R
P
V
V
L
L
C
T
S
G
T
A
A
A
N
Y
F
P
A
V
A
E
A
N
L
S
Q
I
P
L
I
V
L
T
A
D
R
P
H
E
L
R
N
V
G
A
-
P
Q
A
M
D
Q
L
H
L
Y
G
S
H
V
K
-
D
F
T
D
M
A
L
P
E
N
S
E
E
M
L
R
Y
A
K
W
H
G
S
R
A
V
D
I
A
M
K
T
P
R
-
G
P
V
H
L
N
F
P
L
R
E
P
-
L
V
P
I
L
E
P
S
P
F
----------------
Y
Y
T
H
E
V
-
L
D
D
S
S
---
I
Q
K
M
V
T
E
-
C
-
T
G
K
K
G
V
F
V
V
G
P
-
I
D
K
K
E
L
E
Q
P
M
V
D
L
A
K
K
L
G
W
P
I
L
A
D
P
L
S
G
L
R
S
Y
G
A
-
L
D
-
E
V
V
I
D
Q
Y
D
A
F
L
K
E
A
E
I
I
D
K
L
-
T
-
P
E
V
V
I
R
F
G
S
M
P
V
S
K
P
L
K
N
W
L
E
Q
L
S
D
I
R
F
Y
V
V
D
P
G
--
A
A
W
K
D
P
I
K
A
V
T
D
M
I
H
C
D
--
E
R
F
L
L
D
I
M
Q
Q
-
N
M
P
D
D
A
K
D
A
A
W
L
N
G
W
T
S
Y
N
K
V
A
R
E
I
V
L
A
E
-
M
A
N
----
E
-
E
G
K
I
V
A
E
L
R
R
L
L
P
D
K
A
-----
G
L
F
I
G
N
S
M
P
I
R
D
V
D
T
Y
F
S
Q
I
D
-
K
K
I
K
M
L
A
N
R
G
------
A
N
G
I
D
G
V
V
S
S
A
L
G
A
S
-
V
V
--
F
-
Q
-
P
---
M
F
L
L
I
G
D
L
S
F
Y
H
D
M
N
G
L
L
M
A
K
K
Y
K
M
N
L
T
I
V
I
V
N
N
D
-------------------------
E
L
D
F
R
F
A
A
A
F
Y
D
A
D
Y
H
E
A
K
S
V
D
E
L
E
E
A
I
D
K
A
S
Y
H
K
G
L
D
I
I
E
V
K
-------------------------
1
PsiBlast_PDB
97.82
98%
-112
- C7 -
3LQ1
-
MEND_LISMF
A:
[2-555]
-
T
N
H
E
Q
V
L
T
D
Y
L
A
A
F
I
E
E
L
V
Q
A
G
V
K
E
A
I
I
S
P
G
S
R
S
T
P
L
A
L
M
M
A
E
H
P
I
L
K
I
Y
V
D
V
D
E
R
S
A
G
F
F
A
L
G
L
A
K
A
S
K
R
P
V
V
L
L
C
T
S
G
T
A
A
A
N
Y
F
P
A
V
A
E
A
N
L
S
Q
I
P
L
I
V
L
T
A
D
R
P
H
E
L
R
N
V
G
A
-
P
Q
A
M
D
Q
L
H
L
Y
G
S
H
V
K
-
D
F
T
D
M
A
L
P
E
N
S
E
E
M
L
R
Y
A
K
W
H
G
S
R
A
V
D
I
A
M
K
T
P
R
-
G
P
V
H
L
N
F
P
L
R
E
P
-
L
V
P
I
L
E
P
S
P
F
----------------
Y
Y
T
H
E
V
-
L
D
D
S
S
---
I
Q
K
M
V
T
E
-
C
-
T
G
K
K
G
V
F
V
V
G
P
-
I
D
K
K
E
L
E
Q
P
M
V
D
L
A
K
K
L
G
W
P
I
L
A
D
P
L
S
-
G
L
R
S
Y
G
-
A
L
D
E
V
V
I
D
Q
Y
D
A
F
L
K
E
A
E
I
I
D
K
L
-
T
-
P
E
V
V
I
R
F
G
S
M
P
V
S
K
P
L
K
N
W
L
E
Q
L
S
D
I
R
F
Y
V
V
D
P
G
--
A
A
W
K
D
P
I
K
A
V
T
D
M
I
H
C
D
--
E
R
F
L
L
D
I
M
Q
Q
-
N
M
P
D
D
A
K
D
A
A
W
L
N
G
W
T
S
Y
N
K
V
A
R
E
I
V
L
A
E
-
M
A
N
----
E
-
E
G
K
I
V
A
E
L
R
R
L
L
P
D
K
A
-----
G
L
F
I
G
N
S
M
P
I
R
D
V
D
T
Y
F
S
-
Q
I
D
K
K
I
K
M
L
A
N
R
G
------
A
N
G
I
D
G
V
V
S
S
A
L
G
A
S
-
V
V
--
F
-
Q
-
P
---
M
F
L
L
I
G
D
L
S
F
Y
H
D
M
N
G
L
L
M
A
K
K
Y
K
M
N
L
T
I
V
I
V
N
N
D
-------------------------
E
L
D
F
R
F
A
A
A
F
Y
D
A
D
Y
H
E
A
K
S
V
D
E
L
E
E
A
I
D
K
A
S
Y
H
K
G
L
D
I
I
E
V
K
-------------------------
39
HHSearch
82.59
48%
-94
- C7 -
2X7J
8
MEND_BACSU
A:
[27-600]
----
V
N
P
I
T
H
Y
I
G
S
F
I
D
E
F
A
L
S
G
I
T
D
A
V
V
C
P
G
S
R
S
T
P
L
A
V
L
C
A
A
H
P
D
I
S
V
H
V
Q
I
D
E
R
S
A
G
F
F
A
L
G
L
A
K
A
K
Q
R
P
V
L
L
I
C
T
S
G
T
A
A
A
N
F
Y
P
A
V
V
E
A
H
Y
S
R
V
P
I
I
V
L
T
A
D
R
P
H
E
L
R
E
V
G
A
-
P
Q
A
I
N
Q
H
F
L
F
G
N
F
V
K
-
F
F
T
D
S
A
L
P
E
E
S
P
Q
M
L
R
Y
I
R
T
L
A
S
R
A
A
G
E
A
Q
K
R
P
M
-
G
P
V
H
V
N
V
P
L
R
E
P
-
L
M
P
D
L
S
D
E
P
F
G
R
M
---
R
T
G
R
H
--
V
S
V
K
T
G
T
Q
S
-
V
D
R
E
S
---
L
S
D
V
A
E
M
L
A
-
E
A
E
K
G
M
I
V
C
G
E
-
L
H
S
D
A
D
K
E
N
I
I
A
L
S
K
A
L
Q
Y
P
I
L
A
D
P
L
S
-
N
L
R
N
G
V
H
D
K
-
S
T
V
I
D
A
Y
D
S
F
L
K
D
D
E
L
K
R
K
L
-
R
-
P
D
V
V
I
R
F
G
P
M
P
V
S
K
P
V
F
L
W
L
K
D
D
--
P
T
I
Q
Q
I
V
I
D
ED
G
G
W
R
D
P
T
Q
A
S
A
H
M
I
H
C
N
--
A
S
V
F
A
E
E
I
M
A
-
G
L
T
A
A
T
R
S
S
E
W
L
E
K
W
Q
F
V
N
G
R
F
R
E
H
L
Q
T
---
I
S
S
E
D
V
S
F
E
G
N
L
Y
R
I
L
Q
H
L
V
P
E
N
S
-----
S
L
F
V
G
N
S
M
P
I
R
D
V
D
T
F
F
E
-
K
Q
D
R
P
F
R
I
Y
S
N
R
G
------
A
N
G
I
D
G
V
V
S
S
A
M
G
V
C
-
E
G
T-
K
-
A
-
P
---
V
T
L
V
I
G
D
L
S
F
Y
H
D
L
N
G
L
L
A
A
K
K
L
G
I
P
L
T
V
I
L
V
N
N
D
G
G
G
I
F
S
F
L
P
Q
A
S
E
K
T
H
F
E
D
L
F
G
T
P
T
G
L
D
F
K
H
A
A
A
L
Y
G
G
T
Y
S
C
P
A
S
W
D
E
F
K
T
A
Y
A
P
Q
A
D
K
P
G
L
H
L
I
E
I
K
T
D
R
Q
S
R
V
Q
L
H
R
D
M
L
N
E
A
V
R
E
V
K
K
--
23
PsiBlast_CBE
82.17
49%
-95
- C7 -
2X7J
8
MEND_BACSU
B:
[30-588]
-------
I
T
H
Y
I
G
S
F
I
D
E
F
A
L
S
G
I
T
D
A
V
V
C
P
G
S
R
S
T
P
L
A
V
L
C
A
A
H
P
D
I
S
V
H
V
Q
I
D
E
R
S
A
G
F
F
A
L
G
L
A
K
A
K
Q
R
P
V
L
L
I
C
T
S
G
T
A
A
A
N
F
Y
P
A
V
V
E
A
H
Y
S
R
V
P
I
I
V
L
T
A
D
R
P
H
E
L
R
E
V
G
A
-
P
Q
A
I
N
Q
H
F
L
F
G
N
F
V
K
-
F
F
T
D
S
A
L
P
E
E
S
P
Q
M
L
R
Y
I
R
T
L
A
S
R
A
A
G
E
A
Q
K
R
P
M
-
G
P
V
H
V
N
V
P
L
R
E
P
-
L
M
P
D
L
S
D
E
P
F
G
R
M
----
R
T
G
R
H
-
V
S
V
K
T
G
T
Q
S
-
V
D
R
E
S
LSD
V
A
E
M
L
A
E
----
A
E
K
G
M
I
V
C
G
E
-
L
H
S
D
A
D
K
E
N
I
I
A
L
S
K
A
L
Q
Y
P
I
L
A
D
P
L
S
-
N
L
R
N
G
V
-
H
D
K
S
T
V
I
D
A
Y
D
S
F
L
K
D
D
E
L
K
R
K
L
-
R
-
P
D
V
V
I
R
F
G
P
M
P
V
S
K
P
V
F
L
W
L
K
D
D
P
T
I
Q
Q
I
V
I
D
E
D
--
G
G
W
R
D
P
T
Q
A
S
A
H
M
I
H
C
N
--
A
S
V
F
A
E
E
I
M
A
-
G
L
T
A
A
T
R
S
S
E
W
L
E
K
W
Q
F
V
N
G
R
F
R
E
-
H
L
Q
T
-
I
S
S
E
D
V
S
F
-
E
G
N
L
Y
R
I
L
Q
H
L
V
P
E
N
S
-----
S
L
F
V
G
N
S
M
P
I
R
D
V
D
T
F
F
E
-
K
Q
D
R
P
F
R
I
Y
S
N
R
G
------
A
N
G
I
D
G
V
V
S
S
A
M
G
V
C
-
E
G
--
T
-
K
A
P
---
V
T
L
V
I
G
D
L
S
F
Y
H
D
L
N
G
L
L
A
A
K
K
L
G
I
P
L
T
V
I
L
V
N
N
D
G
G
G
I
F
S
F
L
P
Q
A
S
E
K
T
H
F
E
D
L
F
G
T
P
T
G
L
D
F
K
H
A
A
A
L
Y
G
G
T
Y
S
C
P
A
S
W
D
E
F
K
T
A
Y
A
P
Q
A
D
K
P
G
L
H
L
I
E
I
K
T
D
R
Q
S
R
V
Q
L
H
R
--------------
2
PsiBlast_PDB
80.50
49%
-94
- C7 -
2X7J
8
MEND_BACSU
A:
[30-588]
-------
I
T
H
Y
I
G
S
F
I
D
E
F
A
L
S
G
I
T
D
A
V
V
C
P
G
S
R
S
T
P
L
A
V
L
C
A
A
H
P
D
I
S
V
H
V
Q
I
D
E
R
S
A
G
F
F
A
L
G
L
A
K
A
K
Q
R
P
V
L
L
I
C
T
S
G
T
A
A
A
N
F
Y
P
A
V
V
E
A
H
Y
S
R
V
P
I
I
V
L
T
A
D
R
P
H
E
L
R
E
V
G
A
-
P
Q
A
I
N
Q
H
F
L
F
G
N
F
V
K
-
F
F
T
D
S
A
L
P
E
E
S
P
Q
M
L
R
Y
I
R
T
L
A
S
R
A
A
G
E
A
Q
K
R
P
M
-
G
P
V
H
V
N
V
P
L
R
E
P
-
L
M
P
D
L
S
D
E
P
F
G
R
M
----
R
T
G
R
H
-
V
S
V
K
T
G
T
Q
S
-
V
D
R
E
S
L
S
D
V
A
E
M
L
A
E
----
A
E
K
G
M
I
V
C
G
E
-
L
H
S
D
A
D
K
E
N
I
I
A
L
S
K
A
L
Q
Y
P
I
L
A
D
P
L
S
-
N
L
R
N
G
V
-
H
D
K
S
T
V
I
D
A
Y
D
S
F
L
K
D
D
E
L
K
R
K
L
-
R
-
P
D
V
V
I
R
F
G
P
M
P
V
S
K
P
V
F
L
W
L
K
D
D
P
T
I
Q
Q
I
V
I
D
E
D
--
G
G
W
R
D
P
T
Q
A
S
A
H
M
I
H
C
N
--
A
S
V
F
A
E
E
I
M
A
-
G
L
T
A
A
T
R
S
S
E
W
L
E
K
W
Q
F
V
N
G
R
F
R
E
-
H
L
Q
T
-
I
S
S
E
D
V
S
F
-
E
G
N
L
Y
R
I
L
Q
H
L
V
P
E
N
S
-----
S
L
F
V
G
N
S
M
P
I
R
D
V
D
T
F
F
E
-
K
Q
D
R
P
F
R
I
Y
S
N
R
G
------
A
N
G
I
D
G
V
V
S
S
A
M
G
V
C
-
E
G
--
T
-
K
A
P
---
V
T
L
V
I
G
D
L
S
F
Y
H
D
L
N
G
L
L
A
A
K
K
L
G
I
P
L
T
V
I
L
V
N
N
D
G
G
G
I
F
S
F
L
P
Q
A
S
E
K
T
H
F
E
D
L
F
G
T
P
T
G
L
D
F
K
H
A
A
A
L
Y
G
G
T
Y
S
C
P
A
S
W
D
E
F
K
T
A
Y
A
P
Q
A
D
K
P
G
L
H
L
I
E
I
K
T
D
R
Q
S
R
V
Q
L
H
R
--------------
22
PsiBlast_CBE
79.96
49%
-93
- C7 -
2X7J
8
MEND_BACSU
C:
[30-588]
-------
I
T
H
Y
I
G
S
F
I
D
E
F
A
L
S
G
I
T
D
A
V
V
C
P
G
S
R
S
T
P
L
A
V
L
C
A
A
H
P
D
I
S
V
H
V
Q
I
D
E
R
S
A
G
F
F
A
L
G
L
A
K
A
K
Q
R
P
V
L
L
I
C
T
S
G
T
A
A
A
N
F
Y
P
A
V
V
E
A
H
Y
S
R
V
P
I
I
V
L
T
A
D
R
P
H
E
L
R
E
V
G
A
-
P
Q
A
I
N
Q
H
F
L
F
G
N
F
V
K
-
F
F
T
D
S
A
L
P
E
E
S
P
Q
M
L
R
Y
I
R
T
L
A
S
R
A
A
G
E
A
Q
K
R
P
M
-
G
P
V
H
V
N
V
P
L
R
E
P
-
L
M
P
D
L
S
D
E
P
F
G
R
M
----
R
T
G
R
H
-
V
S
V
K
T
G
T
Q
S
-
V
D
R
E
S
LSD
V
A
E
M
L
A
E
----
A
E
K
G
M
I
V
C
G
E
-
L
H
S
D
A
D
K
E
N
I
I
A
L
S
K
A
L
Q
Y
P
I
L
A
D
P
L
S
-
N
L
R
N
G
V
-
H
D
K
S
T
V
I
D
A
Y
D
S
F
L
K
D
D
E
L
K
R
K
L
-
R
-
P
D
V
V
I
R
F
G
P
M
P
V
S
K
P
V
F
L
W
L
K
D
D
P
T
I
Q
Q
I
V
I
D
E
D
--
G
G
W
R
D
P
T
Q
A
S
A
H
M
I
H
C
N
--
A
S
V
F
A
E
E
I
M
A
-
G
L
T
A
A
T
R
S
S
E
W
L
E
K
W
Q
F
V
N
G
R
F
R
E
-
H
L
Q
T
-
I
S
S
E
D
V
S
F
-
E
G
N
L
Y
R
I
L
Q
H
L
V
P
E
N
S
-----
S
L
F
V
G
N
S
M
P
I
R
D
V
D
T
F
F
E
-
K
Q
D
R
P
F
R
I
Y
S
N
R
G
------
A
N
G
I
D
G
V
V
S
S
A
M
G
V
C
-
E
G
--
T
-
K
A
P
---
V
T
L
V
I
G
D
L
S
F
Y
H
D
L
N
G
L
L
A
A
K
K
L
G
I
P
L
T
V
I
L
V
N
N
D
G
G
G
I
F
S
F
L
P
Q
A
S
E
K
T
H
F
E
D
L
F
G
T
P
T
G
L
D
F
K
H
A
A
A
L
Y
G
G
T
Y
S
C
P
A
S
W
D
E
F
K
T
A
Y
A
P
Q
A
D
K
P
G
L
H
L
I
E
I
K
T
D
R
Q
S
R
V
Q
L
H
R
--------------
21
PsiBlast_CBE
79.89
49%
-93
- C7 -
2X7J
7
MEND_BACSU
D:
[30-588]
-------
I
T
H
Y
I
G
S
F
I
D
E
F
A
L
S
G
I
T
D
A
V
V
C
P
G
S
R
S
T
P
L
A
V
L
C
A
A
H
P
D
I
S
V
H
V
Q
I
D
E
R
S
A
G
F
F
A
L
G
L
A
K
A
K
Q
R
P
V
L
L
I
C
T
S
G
T
A
A
A
N
F
Y
P
A
V
V
E
A
H
Y
S
R
V
P
I
I
V
L
T
A
D
R
P
H
E
L
R
E
V
G
A
-
P
Q
A
I
N
Q
H
F
L
F
G
N
F
V
K
-
F
F
T
D
S
A
L
P
E
E
S
P
Q
M
L
R
Y
I
R
T
L
A
S
R
A
A
G
E
A
Q
K
R
P
M
-
G
P
V
H
V
N
V
P
L
R
E
P
-
L
M
P
D
L
S
D
E
P
F
G
R
M
----
R
T
G
R
H
-
V
S
V
K
T
G
T
Q
S
-
V
D
R
E
S
LSD
V
A
E
M
L
A
E
----
A
E
K
G
M
I
V
C
G
E
-
L
H
S
D
A
D
K
E
N
I
I
A
L
S
K
A
L
Q
Y
P
I
L
A
D
P
L
S
-
N
L
R
N
G
V
-
H
D
K
S
T
V
I
D
A
Y
D
S
F
L
K
D
D
E
L
K
R
K
L
-
R
-
P
D
V
V
I
R
F
G
P
M
P
V
S
K
P
V
F
L
W
L
K
D
D
P
T
I
Q
Q
I
V
I
D
E
D
--
G
G
W
R
D
P
T
Q
A
S
A
H
M
I
H
C
N
--
A
S
V
F
A
E
E
I
M
A
-
G
L
T
A
A
T
R
S
S
E
W
L
E
K
W
Q
F
V
N
G
R
F
R
E
-
H
L
Q
T
-
I
S
S
E
D
V
S
F
-
E
G
N
L
Y
R
I
L
Q
H
L
V
P
E
N
S
-----
S
L
F
V
G
N
S
M
P
I
R
D
V
D
T
F
F
E
-
K
Q
D
R
P
F
R
I
Y
S
N
R
G
------
A
N
G
I
D
G
V
V
S
S
A
M
G
V
C
-
E
G
--
T
-
K
A
P
---
V
T
L
V
I
G
D
L
S
F
Y
H
D
L
N
G
L
L
A
A
K
K
L
G
I
P
L
T
V
I
L
V
N
N
D
G
G
G
I
F
S
F
L
P
Q
A
S
E
K
T
H
F
E
D
L
F
G
T
P
T
G
L
D
F
K
H
A
A
A
L
Y
G
G
T
Y
S
C
P
A
S
W
D
E
F
K
T
A
Y
A
P
Q
A
D
K
P
G
L
H
L
I
E
I
K
T
D
R
Q
S
R
V
Q
L
H
R
--------------
4
PsiBlast_PDB
66.01
30%
-76
- C7 -
3FLM
-
MEND_ECOLI
A:
[10-554]
----------
W
A
A
V
I
L
E
A
L
T
R
H
G
V
R
H
I
C
I
A
P
G
S
R
S
T
L
L
T
L
A
A
A
E
N
S
A
F
I
H
H
T
H
F
D
E
R
G
L
G
H
L
A
L
G
L
A
K
V
S
K
Q
P
V
A
V
I
V
T
S
G
T
A
V
A
N
L
Y
P
A
L
I
E
A
G
L
T
G
E
K
L
I
L
L
T
A
D
R
P
P
E
L
I
D
C
G
A
-
N
Q
A
I
R
Q
P
G
M
F
A
S
H
P
T
-
H
--
S
I
S
L
P
R
P
T
Q
D
I
--
P
A
R
W
L
V
S
-
T
I
D
H
A
L
G
T
L
H
A
G
G
V
H
I
N
C
P
F
A
E
P
-
L
---
M
D
D
T
G
L
S
W
Q
Q
RL
G
D
W
W
Q
D
-
D
K
P
W
L
R
E
A
P
-
R
L
E
S
E
---
K
Q
R
D
W
F
F
-
W
-
R
Q
K
R
G
V
V
V
A
G
R
-
M
S
A
E
E
G
K
K
-
V
A
L
W
A
Q
T
L
G
W
P
L
I
G
D
V
L
S
-
Q
T
G
Q
--------
P
L
P
C
A
D
L
W
L
G
N
A
K
A
T
S
E
L
-
Q
Q
A
Q
I
V
V
Q
L
G
S
S
L
T
G
K
R
L
L
Q
W
Q
A
S
C
E
P
E
E
Y
W
I
V
D
D
I
--
E
G
R
L
D
P
A
H
------
H
R
G
--
R
R
L
I
A
N
I
A
D
W
L
E
L
H
P
A
E
K
R
Q
P
W
C
---
V
E
I
P
R
L
A
E
Q
A
M
Q
A
V
-
I
A
R
R
D
A
F
G
-
E
A
Q
L
A
H
R
I
C
D
Y
L
P
E
Q
G
-----
Q
L
F
V
G
N
S
L
V
V
R
L
I
D
A
-
L
S
-
Q
L
P
A
G
Y
P
V
Y
S
N
R
G
------
A
S
G
I
D
G
L
L
S
T
A
A
G
V
Q
R
A
S
--
G
-
K
-
P
---
T
L
A
I
V
G
D
L
S
A
L
Y
D
L
N
A
L
A
L
L
R
Q
V
S
A
P
L
V
L
I
V
V
N
N
N
G
-------------------
Y
L
M
P
Q
N
V
H
F
E
H
A
A
A
M
F
E
L
K
Y
H
R
P
Q
N
W
Q
E
L
E
T
A
F
A
D
A
W
R
T
P
T
T
T
V
I
E
M
V
V
N
D
T
D
G
A
Q
T
L
Q
Q
L
L
A
Q
V
S
-------
24
PsiBlast_CBE
65.79
31%
-71
- C7 -
2JLC
3
MEND_ECOLI
B:
[31-575]
----------
W
A
A
V
I
L
E
A
L
T
R
H
G
V
R
H
I
C
I
A
P
G
S
R
S
T
P
L
T
L
A
A
A
E
N
S
A
F
I
H
H
T
H
F
D
E
R
G
L
G
H
L
A
L
G
L
A
K
V
S
K
Q
P
V
A
V
I
V
T
S
G
T
A
V
A
N
L
Y
P
A
L
I
E
A
G
L
T
G
E
K
L
I
L
L
T
A
D
R
P
P
E
L
I
D
C
G
A
-
N
Q
A
I
R
Q
P
G
M
F
A
S
H
P
T
-
H
--
S
I
S
L
P
R
P
T
Q
D
I
--
P
A
R
W
L
V
S
-
T
I
D
H
A
L
G
T
L
H
A
G
G
V
H
I
N
C
P
F
A
E
P
-
L
Y
G
E
M
D
D
T
G
L
S
W
Q
Q
R
L
G
D
W
W
Q
D
-
D
K
P
W
L
R
E
A
P
-
R
L
E
S
E
---
K
Q
R
D
W
F
F
-
W
-
R
Q
K
R
G
V
V
V
A
G
R
-
M
S
A
E
E
G
K
K
-
V
A
L
W
A
Q
T
L
G
W
P
L
I
G
D
V
L
S
-
Q
T
G
Q
--------
P
L
P
C
A
D
L
W
L
G
N
A
K
A
T
S
E
L
-
Q
Q
A
Q
I
V
V
Q
L
G
S
S
L
T
G
K
R
L
L
Q
W
Q
A
S
C
E
P
E
E
Y
W
I
V
D
D
I
--
E
G
R
L
D
P
A
H
------
H
R
G
--
R
R
L
I
A
N
I
A
D
W
L
E
L
H
P
A
E
K
R
Q
P
W
C
---
V
E
I
P
R
L
A
E
Q
A
M
Q
A
V
-
I
A
R
R
D
A
F
G
-
E
A
Q
L
A
H
R
I
C
D
Y
L
P
E
Q
G
-----
Q
L
F
V
G
N
S
L
V
V
R
L
I
D
A
-
L
S
-
Q
L
P
A
G
Y
P
V
Y
S
N
R
G
------
A
S
G
I
D
G
L
L
S
T
A
A
G
V
Q
R
A
S
--
G
-
K
-
P
---
T
L
A
I
V
G
D
L
S
A
L
Y
D
L
N
A
L
A
L
L
R
Q
V
S
A
P
L
V
L
I
V
V
N
N
N
G
G
Q
I
F
S
L
L
P
T
P
Q
S
E
R
--
E
R
F
Y
L
M
P
Q
N
V
H
F
E
H
A
A
A
M
F
E
L
K
Y
H
R
P
Q
N
W
Q
E
L
E
T
A
F
A
D
A
W
R
T
P
T
T
T
V
I
E
M
V
V
N
D
T
D
G
A
Q
T
L
Q
Q
L
L
A
Q
V
S
-------
7
PsiBlast_PDB
65.70
31%
-73
- C7 -
2JLA
7
MEND_ECOLI
A:
[12-556]
----------
W
A
A
V
I
L
E
A
L
T
R
H
G
V
R
H
I
C
I
A
P
G
S
R
S
T
P
L
T
L
A
A
A
E
N
S
A
F
I
H
H
T
H
F
D
E
R
G
L
G
H
L
A
L
G
L
A
K
V
S
K
Q
P
V
A
V
I
V
T
S
G
T
A
V
A
N
L
Y
P
A
L
I
E
A
G
L
T
G
E
K
L
I
L
L
T
A
D
R
P
P
E
L
I
D
C
G
A
-
N
Q
A
I
R
Q
P
G
M
F
A
S
H
P
T
-
H
--
S
I
S
L
P
R
P
T
Q
D
I
--
P
A
R
W
L
V
S
-
T
I
D
H
A
L
G
T
L
H
A
G
G
V
H
I
N
C
P
F
A
E
P
-
L
Y
G
E
M
D
D
T
G
L
S
W
Q
Q
R
L
G
D
W
W
Q
D
-
D
K
P
W
L
R
E
A
P
-
R
L
E
S
E
---
K
Q
R
D
W
F
F
-
W
-
R
Q
K
R
G
V
V
V
A
G
R
-
M
S
A
E
E
G
K
K
-
V
A
L
W
A
Q
T
L
G
W
P
L
I
G
D
V
L
S
-
Q
T
G
Q
--------
P
L
P
C
A
D
L
W
L
G
N
A
K
A
T
S
E
L
-
Q
Q
A
Q
I
V
V
Q
L
G
S
S
L
T
G
K
R
L
L
Q
W
Q
A
S
C
E
P
E
E
Y
W
I
V
D
D
I
--
E
G
R
L
D
P
A
H
------
H
R
G
--
R
R
L
I
A
N
I
A
D
W
L
E
L
H
P
A
E
K
R
Q
P
W
C
---
V
E
I
P
R
L
A
E
Q
A
M
Q
A
V
-
I
A
R
R
D
A
F
G
-
E
A
Q
L
A
H
R
I
C
D
Y
L
P
E
Q
G
-----
Q
L
F
V
G
N
S
L
V
V
R
L
I
D
A
-
L
S
-
Q
L
P
A
G
Y
P
V
Y
S
N
R
G
------
A
S
G
I
D
G
L
L
S
T
A
A
G
V
Q
R
A
S
--
G
-
K
-
P
---
T
L
A
I
V
G
D
L
S
A
L
Y
D
L
N
A
L
A
L
L
R
Q
V
S
A
P
L
V
L
I
V
V
N
N
N
G
G
Q
I
F
S
L
L
P
T
P
Q
S
E
R
--
E
R
F
Y
L
M
P
Q
N
V
H
F
E
H
A
A
A
M
F
E
L
K
Y
H
R
P
Q
N
W
Q
E
L
E
T
A
F
A
D
A
W
R
T
P
T
T
T
V
I
E
M
V
V
N
D
T
D
G
A
Q
T
L
Q
Q
L
L
A
Q
V
S
-------
5
PsiBlast_PDB
65.40
30%
-75
- C7 -
3HWW
24
MEND_ECOLI
A:
[10-554]
----------
W
A
A
V
I
L
E
A
L
T
R
H
G
V
R
H
I
C
I
A
P
G
S
R
S
T
L
L
T
L
A
A
A
E
N
S
A
F
I
H
H
T
H
F
D
E
R
G
L
G
H
L
A
L
G
L
A
K
V
S
K
Q
P
V
A
V
I
V
T
S
G
T
A
V
A
N
L
Y
P
A
L
I
E
A
G
L
T
G
E
K
L
I
L
L
T
A
D
R
P
P
E
L
I
D
C
G
A
-
N
Q
A
I
R
Q
P
G
M
F
A
S
H
P
T
-
H
--
S
I
S
L
P
R
P
T
Q
D
I
--
P
A
R
W
L
V
S
-
T
I
D
H
A
L
G
T
L
H
A
G
G
V
H
I
N
C
P
F
A
E
P
-
L
Y
G
E
M
D
D
T
G
L
S
W
Q
Q
R
L
G
D
W
W
Q
D
-
D
K
P
W
L
R
E
A
P
-
R
L
E
S
E
---
K
Q
R
D
W
F
F
-
W
-
R
Q
K
R
G
V
V
V
A
G
R
-
M
S
A
E
E
G
K
K
-
V
A
L
W
A
Q
T
L
G
W
P
L
I
G
D
V
L
S
-
Q
T
G
Q
--------
P
L
P
C
A
D
L
W
L
G
N
A
K
A
T
S
E
L
-
Q
Q
A
Q
I
V
V
Q
L
G
S
S
L
T
G
K
R
L
L
Q
W
Q
A
S
C
E
P
E
E
Y
W
I
V
D
D
I
--
E
G
R
L
D
P
A
H
------
H
R
G
--
R
R
L
I
A
N
I
A
D
W
L
E
L
H
P
A
E
K
R
Q
P
W
C
---
V
E
I
P
R
L
A
E
Q
A
M
Q
A
V
-
I
A
R
R
D
A
F
G
-
E
A
Q
L
A
H
R
I
C
D
Y
L
P
E
Q
G
-----
Q
L
F
V
G
N
S
L
V
V
R
L
I
D
A
-
L
S
-
Q
L
P
A
G
Y
P
V
Y
S
N
R
G
------
A
S
G
I
D
G
L
L
S
T
A
A
G
V
Q
R
A
S
--
G
-
K
-
P
---
T
L
A
I
V
G
D
L
S
A
L
Y
D
L
N
A
L
A
L
L
R
Q
V
S
A
P
L
V
L
I
V
V
N
N
N
G
-------------------
Y
L
M
P
Q
N
V
H
F
E
H
A
A
A
M
F
E
L
K
Y
H
R
P
Q
N
W
Q
E
L
E
T
A
F
A
D
A
W
R
T
P
T
T
T
V
I
E
M
V
V
N
D
T
D
G
A
Q
T
L
Q
Q
L
L
A
Q
V
S
-------
3
PsiBlast_PDB
65.07
31%
-75
- C7 -
2JLC
3
MEND_ECOLI
A:
[31-575]
----------
W
A
A
V
I
L
E
A
L
T
R
H
G
V
R
H
I
C
I
A
P
G
S
R
S
T
P
L
T
L
A
A
A
E
N
S
A
F
I
H
H
T
H
F
D
E
R
G
L
G
H
L
A
L
G
L
A
K
V
S
K
Q
P
V
A
V
I
V
T
S
G
T
A
V
A
N
L
Y
P
A
L
I
E
A
G
L
T
G
E
K
L
I
L
L
T
A
D
R
P
P
E
L
I
D
C
G
A
-
N
Q
A
I
R
Q
P
G
M
F
A
S
H
P
T
-
H
--
S
I
S
L
P
R
P
T
Q
D
I
--
P
A
R
W
L
V
S
-
T
I
D
H
A
L
G
T
L
H
A
G
G
V
H
I
N
C
P
F
A
E
P
-
L
Y
--
M
D
D
T
G
L
S
W
Q
Q
R
L
G
D
W
W
Q
D
-
D
K
P
W
L
R
E
A
P
-
R
L
E
S
E
---
K
Q
R
D
W
F
F
-
W
-
R
Q
K
R
G
V
V
V
A
G
R
-
M
S
A
E
E
G
K
K
-
V
A
L
W
A
Q
T
L
G
W
P
L
I
G
D
V
L
S
-
Q
T
G
Q
--------
P
L
P
C
A
D
L
W
L
G
N
A
K
A
T
S
E
L
-
Q
Q
A
Q
I
V
V
Q
L
G
S
S
L
T
G
K
R
L
L
Q
W
Q
A
S
C
E
P
E
E
Y
W
I
V
D
D
I
--
E
G
R
L
D
P
A
H
------
H
R
G
--
R
R
L
I
A
N
I
A
D
W
L
E
L
H
P
A
E
K
R
Q
P
W
C
---
V
E
I
P
R
L
A
E
Q
A
M
Q
A
V
-
I
A
R
R
D
A
F
G
-
E
A
Q
L
A
H
R
I
C
D
Y
L
P
E
Q
G
-----
Q
L
F
V
G
N
S
L
V
V
R
L
I
D
A
-
L
S
-
Q
L
P
A
G
Y
P
V
Y
S
N
R
G
------
A
S
G
I
D
G
L
L
S
T
A
A
G
V
Q
R
A
S
--
G
-
K
-
P
---
T
L
A
I
V
G
D
L
S
A
L
Y
D
L
N
A
L
A
L
L
R
Q
V
S
A
P
L
V
L
I
V
V
N
N
N
G
G
Q
I
F
S
L
L
P
T
P
Q
S
E
R
--
E
R
F
Y
L
M
P
Q
N
V
H
F
E
H
A
A
A
M
F
E
L
K
Y
H
R
P
Q
N
W
Q
E
L
E
T
A
F
A
D
A
W
R
T
P
T
T
T
V
I
E
M
V
V
N
D
T
D
G
A
Q
T
L
Q
Q
L
L
A
Q
V
S
-------
6
PsiBlast_PDB
64.92
30%
-75
- C7 -
3HWX
5
MEND_ECOLI
A:
[10-554]
----------
W
A
A
V
I
L
E
A
L
T
R
H
G
V
R
H
I
C
I
A
P
G
S
R
S
T
L
L
T
L
A
A
A
E
N
S
A
F
I
H
H
T
H
F
D
E
R
G
L
G
H
L
A
L
G
L
A
K
V
S
K
Q
P
V
A
V
I
V
T
S
G
T
A
V
A
N
L
Y
P
A
L
I
E
A
G
L
T
G
E
K
L
I
L
L
T
A
D
R
P
P
E
L
I
D
C
G
A
-
N
Q
A
I
R
Q
P
G
M
F
A
S
H
P
T
-
H
--
S
I
S
L
P
R
P
T
Q
D
I
--
P
A
R
W
L
V
S
-
T
I
D
H
A
L
G
T
L
H
A
G
G
V
H
I
N
C
P
F
A
E
P
-
L
Y
G
-
M
D
D
T
G
L
S
W
Q
Q
RL
G
D
W
W
Q
D
-
D
K
P
W
L
R
E
A
P
-
R
L
E
S
E
---
K
Q
R
D
W
F
F
-
W
-
R
Q
K
R
G
V
V
V
A
G
R
-
M
S
A
E
E
G
K
K
-
V
A
L
W
A
Q
T
L
G
W
P
L
I
G
D
V
L
S
-
Q
T
G
Q
--------
P
L
P
C
A
D
L
W
L
G
N
A
K
A
T
S
E
L
-
Q
Q
A
Q
I
V
V
Q
L
G
S
S
L
T
G
K
R
L
L
Q
W
Q
A
S
C
E
P
E
E
Y
W
I
V
D
D
I
--
E
G
R
L
D
P
A
H
------
H
R
G
--
R
R
L
I
A
N
I
A
D
W
L
E
L
H
P
A
E
K
R
Q
P
W
C
---
V
E
I
P
R
L
A
E
Q
A
M
Q
A
V
-
I
A
R
R
D
A
F
G
-
E
A
Q
L
A
H
R
I
C
D
Y
L
P
E
Q
G
-----
Q
L
F
V
G
N
S
L
V
V
R
L
I
D
A
-
L
S
-
Q
L
P
A
G
Y
P
V
Y
S
N
R
G
------
A
S
G
I
D
G
L
L
S
T
A
A
G
V
Q
R
A
S
--
G
-
K
-
P
---
T
L
A
I
V
G
D
L
S
A
L
Y
D
L
N
A
L
A
L
L
R
Q
V
S
A
P
L
V
L
I
V
V
N
N
N
G
G
Q
I
F
S
L
L
P
T
P
Q
S
E
R
--
E
R
F
Y
L
M
P
Q
N
V
H
F
E
H
A
A
A
M
F
E
L
K
Y
H
R
P
Q
N
W
Q
E
L
E
T
A
F
A
D
A
W
R
T
P
T
T
T
V
I
E
M
V
V
N
D
T
D
G
A
Q
T
L
Q
Q
L
L
A
Q
V
S
-------
63
Fugue
63.36
30%
-75
- C7 -
2JLC
3
MEND_ECOLI
A:
[22-577]
-
M
S
V
S
A
F
N
R
R
W
A
A
V
I
L
E
A
L
T
R
H
G
V
R
H
I
C
I
A
P
G
S
R
S
T
P
L
T
L
A
A
A
E
N
S
A
F
I
H
H
T
H
F
D
E
R
G
L
G
H
L
A
L
G
L
A
K
V
S
K
Q
P
V
A
V
I
V
T
S
G
T
A
V
A
N
L
Y
P
A
L
I
E
A
G
L
T
G
E
K
L
I
L
L
T
A
D
R
P
P
E
L
I
D
C
G
A
-
N
Q
A
I
R
Q
P
G
M
F
A
S
H
P
T
-
H
S
I
S
L
P
R
P
T
Q
D
I
P
----
A
R
W
L
V
S
T
I
D
H
A
L
G
T
L
H
A
-
G
G
V
H
I
N
C
P
F
A
E
P
-
L
Y
M
D
D
T
G
L
S
W
Q
Q
R
---
L
G
D
W
W
Q
-
D
D
K
P
W
L
R
E
A
-
P
R
L
E
S
---
E
K
Q
R
D
W
F
-
F
W
R
Q
K
R
G
V
V
V
A
G
R
-
M
S
A
E
E
G
K
K
-
V
A
L
W
A
Q
T
L
G
W
P
L
I
G
D
V
L
S
-
Q
T
G
Q
P
--------
L
P
C
A
D
L
W
L
G
N
A
K
A
T
S
E
L
Q
Q
-
A
Q
I
V
V
Q
L
G
S
S
L
T
G
K
R
L
L
Q
W
Q
A
S
C
E
P
E
E
Y
W
I
V
D
D
I
--
E
G
R
L
D
P
A
H
H
R
G
R
R
L
I
A
N
--
I
A
D
W
L
E
L
H
P
A
-
E
K
R
Q
--------
P
W
C
V
E
I
P
R
L
A
E
Q
A
M
Q
A
V
-
I
A
R
R
D
A
F
G
-
E
A
Q
L
A
H
R
I
C
D
Y
L
P
E
Q
G
-----
Q
L
F
V
G
N
S
L
V
V
R
L
I
D
A
L
S
--
Q
L
P
A
G
Y
P
V
Y
S
N
R
G
------
A
S
G
I
D
G
L
L
S
T
A
A
G
V
Q
-
R
A
--
S
G
K
-
P
---
T
L
A
I
V
G
D
L
S
A
L
Y
D
L
N
A
L
A
L
L
R
Q
V
S
A
P
L
V
L
I
V
V
N
N
N
G
G
Q
I
F
S
L
L
P
T
P
--
Q
S
E
R
E
R
F
Y
L
M
P
Q
N
V
H
F
E
H
A
A
A
M
F
E
L
K
Y
H
R
P
Q
N
W
Q
E
L
E
T
A
F
A
D
A
W
R
T
P
T
T
T
V
I
E
M
V
V
N
D
T
D
G
A
Q
T
L
Q
Q
L
L
A
Q
V
S
H
L
-----
45
HHSearch
59.26
29%
-69
- C7 -
3HWW
24
MEND_ECOLI
A:
[5-555]
-----
A
F
N
R
R
W
A
A
V
I
L
E
A
L
T
R
H
G
V
R
H
I
C
I
A
P
G
S
R
S
T
L
L
T
L
A
A
A
E
N
S
A
F
I
H
H
T
H
F
D
E
R
G
L
G
H
L
A
L
G
L
A
K
V
S
K
Q
P
V
A
V
I
V
T
S
G
T
A
V
A
N
L
Y
P
A
L
I
E
A
G
L
T
G
E
K
L
I
L
L
T
A
D
R
P
P
E
L
I
D
C
G
A
-
N
Q
A
I
R
Q
P
G
M
F
A
S
H
P
T
-
H
S
I
S
L
P
R
P
T
Q
-
D
I
P
A
R
W
L
V
S
T
I
D
H
A
L
G
T
L
---
H
A
-
G
G
V
H
I
N
C
P
F
A
E
P
L
Y
G
E
M
D
D
T
G
L
S
W
Q
Q
---
R
L
G
D
W
W
Q
D
D
K
P
W
L
R
E
A
-
P
R
L
E
S
---
E
K
Q
R
D
W
F
F
W
-
R
Q
K
R
G
V
V
V
A
G
R
-
M
S
A
E
-
E
G
K
K
V
A
L
W
A
Q
T
L
G
W
P
L
I
G
D
V
L
S
-
Q
T
G
Q
P
L
P
C
A
-
D
L
W
L
G
N
A
------
K
A
T
S
E
L
Q
-
Q
-
A
Q
I
V
V
Q
L
G
S
S
L
T
G
K
R
L
L
Q
W
Q
A
S
C
E
P
E
E
Y
W
I
V
D
D
I
--
E
G
R
L
D
P
A
H
H
R
G
R
R
L
I
A
N
--
I
A
D
W
L
E
L
H
P
A
-
E
-----
K
R
Q
P
W
C
V
E
I
P
R
L
A
E
Q
A
M
Q
A
V
----
I
A
R
R
D
A
F
G
-
E
A
Q
L
A
H
R
I
C
D
Y
L
P
E
Q
G
-----
Q
L
F
V
G
N
S
L
V
V
R
L
I
D
A
L
S
Q
-
L
P
-
A
G
Y
P
V
Y
S
N
R
G
------
A
S
G
I
D
G
L
L
S
T
A
A
G
V
Q
-
R
A
S
-
G
-
K
-
P
---
T
L
A
I
V
G
D
L
S
A
L
Y
D
L
N
A
L
A
L
L
R
Q
V
S
A
P
L
V
L
I
V
V
N
N
N
G
-------------------
Y
L
M
P
Q
N
V
H
F
E
H
A
A
A
M
F
E
L
K
Y
H
R
P
Q
N
W
Q
E
L
E
T
A
F
A
D
A
W
R
T
P
T
T
T
V
I
E
M
V
V
N
D
T
D
G
A
Q
T
L
Q
Q
L
L
A
Q
V
S
H
------
48
HHSearch
58.61
15%
-84
- C7 -
3EYA
11
POXB_ECOLI
A:
[2-536]
-------
K
Q
T
V
A
A
Y
I
A
K
T
L
E
S
A
G
V
K
R
I
W
G
V
T
G
D
S
L
N
G
L
S
D
S
L
N
R
M
G
T
I
E
W
M
S
T
R
H
E
E
V
A
A
F
A
A
G
A
E
A
Q
L
S
G
E
L
A
V
C
A
G
S
C
G
P
G
N
L
H
L
I
N
G
L
F
D
C
H
R
N
H
V
P
V
L
A
I
A
A
H
I
P
S
S
E
I
G
S
G
Y
-
F
Q
E
T
H
P
Q
E
L
F
R
E
C
S
H
-
Y
C
E
L
V
S
S
P
E
Q
-------
I
P
Q
V
L
A
I
A
M
R
K
A
V
L
-
N
R
-
G
V
S
V
V
V
L
P
G
D
V
A
-
L
K
P
A
P
E
G
A
T
M
H
--------
W
Y
--
H
-
A
P
Q
P
V
V
T
-
P
E
E
E
E
---
L
R
K
L
A
Q
L
L
R
-
Y
S
S
N
I
A
L
M
C
G
S
-
G
C
A
-
G
A
H
K
E
L
V
E
F
A
G
K
I
K
A
P
I
V
H
A
L
R
G
-
K
E
H
V
E
Y
-
D
N
-
P
Y
D
V
G
M
T
G
L
I
G
F
S
S
G
F
H
T
M
M
-
N
-
A
D
T
L
V
L
L
G
T
Q
F
P
Y
R
A
F
--
Y
P
---
T
D
A
K
I
I
Q
I
D
I
N
--
P
A
S
I
G
A
H
S
K
V
D
M
A
L
V
G
D
--
I
K
S
T
L
R
A
L
L
P
-
L
V
E
E
K
A
-
D
R
K
F
L
D
K
A
L
E
D
Y
R
D
A
R
K
G
L
D
D
L
A
K
P
S
E
K
A
I
H
-
P
Q
Y
L
A
Q
Q
I
S
H
F
A
A
D
D
A
-----
I
F
T
C
D
V
G
T
P
T
V
W
A
A
R
Y
L
K
-
M
N
-
G
K
R
R
L
L
G
S
F
N
------
H
G
S
M
A
N
A
M
P
Q
A
L
G
A
Q
-
A
T
E
P
E
-
R
-
Q
---
V
V
A
M
C
G
D
G
G
F
S
M
L
M
G
D
F
L
S
V
V
Q
M
K
L
P
V
K
I
V
V
F
N
N
S
V
L
G
F
V
---------------
G
T
E
L
H
D
T
N
F
A
R
I
A
E
A
C
G
I
T
G
I
R
V
E
K
A
S
E
V
D
E
A
L
Q
R
A
F
S
I
D
G
P
V
L
V
D
V
V
V
A
K
E
E
L
A
I
P
P
---------------
16
PsiBlast_PDB
58.09
22%
-69
- C7 -
4QEL
6
MDLC_PSEPU
A:
[10-523]
----------------
E
L
L
R
R
Q
G
I
D
T
V
F
G
N
P
G
S
N
E
L
P
F
L
K
D
F
P
E
D
--
F
R
Y
I
L
A
L
Q
E
A
C
V
V
G
I
A
D
G
Y
A
Q
A
S
R
K
P
A
F
I
N
L
A
S
A
A
G
T
G
N
A
M
G
A
L
S
N
A
W
N
S
H
S
P
L
I
V
T
A
G
Q
Q
T
R
A
M
I
G
V
E
A
L
L
T
N
V
D
A
A
N
L
P
R
P
L
V
K
W
S
Y
E
P
A
S
A
A
E
V
P
H
A
M
--------
S
R
A
I
H
M
A
S
M
A
P
Q
-
G
P
V
Y
L
S
V
P
Y
D
D
---------
W
D
K
D
A
D
---
P
Q
S
H
H
L
-
F
D
R
H
V
S
S
S
V
R
L
N
D
Q
D
---
L
D
I
L
V
K
A
-
L
N
S
A
S
N
P
A
I
V
L
G
P
D
V
D
A
A
N
A
N
A
D
C
V
M
L
A
E
R
L
K
A
P
V
W
V
A
P
S
A
-
P
R
C
P
F
P
-
T
R
H
P
C
F
R
G
L
M
P
A
G
I
--
A
A
I
S
Q
L
L
-
E
-
G
H
D
V
V
L
V
I
G
A
P
V
-------------
F
R
Y
H
Q
Y
D
P
G
--
Q
Y
L
K
P
G
T
R
L
I
S
--
V
T
C
D
--
P
---
L
E
A
A
R
A
-
P
M
-
G
D
A
I
V
A
D
I
G
A
M
A
S
A
L
A
N
L
V
E
E
S
--
S
R
-
Q
L
P
T
A
A
P
E
-
P
A
K
V
D
Q
D
A
G
R
L
H
P
E
T
V
F
D
T
L
N
D
M
A
P
E
N
A
I
Y
L
N
E
S
T
S
T
T
A
-
Q
M
W
Q
R
L
N
M
R
-
N
P
G
S
Y
Y
F
CA
A
G
G
L
G
F
A
L
P
A
A
I
G
V
Q
-
L
A
----
E
-
P
E
R
Q
V
I
A
V
I
G
D
G
S
A
N
Y
S
I
S
A
L
W
T
A
A
Q
Y
N
I
P
T
I
F
V
I
M
N
N
G
T
Y
G
A
L
R
W
F
A
G
V
L
E
A
E
N
V
P
G
L
--
D
V
P
G
I
D
F
R
A
L
A
K
G
Y
G
V
Q
A
L
K
A
D
N
L
E
Q
L
K
G
S
L
Q
E
A
L
S
A
K
G
P
V
L
I
E
V
S
T
------------------------
19
PsiBlast_PDB
57.95
22%
-71
- C7 -
4JU9
4
MDLC_PSEPU
A:
[10-523]
----------------
E
L
L
R
R
Q
G
I
D
T
V
F
G
N
P
G
S
N
E
L
P
F
L
K
D
F
P
E
D
--
F
R
Y
I
L
A
L
Q
E
A
C
V
V
G
I
A
D
G
Y
A
Q
A
S
R
K
P
A
F
I
N
L
L
S
A
A
G
T
G
N
A
M
G
A
L
S
N
A
W
N
S
H
S
P
L
I
V
T
A
G
Q
Q
T
R
A
M
I
G
V
E
A
L
L
T
N
V
D
A
A
N
L
P
R
P
L
V
K
W
S
Y
E
P
A
S
A
A
E
V
P
H
A
M
--------
S
R
A
I
H
M
A
S
M
A
P
Q
-
G
P
V
Y
L
S
V
P
Y
D
D
---------
W
D
K
D
A
D
---
P
Q
S
H
H
L
-
F
D
R
H
V
S
S
S
V
R
L
N
D
Q
D
---
L
D
I
L
V
K
A
-
L
N
S
A
S
N
P
A
I
V
L
G
P
D
V
D
A
A
N
A
N
A
D
C
V
M
L
A
E
R
L
K
A
P
V
W
V
A
P
S
A
-
P
R
C
P
F
P
-
T
R
H
P
C
F
R
G
L
M
P
A
G
I
--
A
A
I
S
Q
L
L
-
E
-
G
H
D
V
V
L
V
I
G
A
P
V
-------------
F
R
Y
H
Q
Y
D
P
G
--
Q
Y
L
K
P
G
T
R
L
I
S
--
V
T
C
D
--
P
---
L
E
A
A
R
A
-
P
M
-
G
D
A
I
V
A
D
I
G
A
M
A
S
A
L
A
N
L
V
E
E
S
--
S
R
-
Q
L
P
T
A
A
P
E
-
P
A
K
V
D
Q
D
A
G
R
L
H
P
E
T
V
F
D
T
L
N
D
M
A
P
E
N
A
I
Y
L
N
E
S
T
S
T
T
A
-
Q
M
W
Q
R
L
N
M
R
-
N
P
G
S
Y
Y
F
CA
A
G
G
L
G
F
A
L
P
A
A
I
G
V
Q
-
L
A
----
E
-
P
E
R
Q
V
I
A
V
I
G
D
G
S
A
N
Y
S
I
S
A
L
W
T
A
A
Q
Y
N
I
P
T
I
F
V
I
M
N
N
G
T
Y
G
A
L
R
W
F
A
G
V
L
E
A
E
N
V
P
G
L
--
D
V
P
G
I
D
F
R
A
L
A
K
G
Y
G
V
Q
A
L
K
A
D
N
L
E
Q
L
K
G
S
L
Q
E
A
L
S
A
K
G
P
V
L
I
E
V
S
T
------------------------
15
PsiBlast_PDB
57.66
22%
-71
- C7 -
4GM4
6
MDLC_PSEPU
A:
[10-523]
----------------
E
L
L
R
R
Q
G
I
D
T
V
F
G
N
P
G
S
N
E
L
P
F
L
K
D
F
P
E
D
--
F
R
Y
I
L
A
L
Q
E
A
C
V
V
G
I
A
D
G
Y
A
Q
A
S
R
K
P
A
F
I
N
L
H
S
A
A
G
T
G
N
A
M
G
A
L
S
N
A
W
N
S
H
S
P
L
I
V
T
A
G
Q
Q
T
R
A
M
I
G
V
E
A
L
L
T
N
V
D
A
A
N
L
P
R
P
L
V
K
W
S
Y
E
P
A
S
A
A
E
V
P
H
A
M
--------
S
R
A
I
H
M
A
S
M
A
P
Q
-
G
P
V
Y
L
S
V
P
Y
D
D
---------
W
D
K
D
A
D
---
P
Q
S
H
H
L
-
F
D
R
H
V
S
S
S
V
R
L
N
D
Q
D
---
L
D
I
L
V
K
A
-
L
N
S
A
S
N
P
A
I
V
L
G
P
D
V
D
A
A
N
A
N
A
D
C
V
M
L
A
E
R
L
K
A
P
V
W
V
A
P
S
A
-
P
R
C
P
F
P
-
T
R
H
P
C
F
R
G
L
M
P
A
G
I
--
A
A
I
S
Q
L
L
-
E
-
G
H
D
V
V
L
V
I
G
A
P
V
-------------
F
R
Y
H
Q
Y
D
P
G
--
Q
Y
L
K
P
G
T
R
L
I
S
--
V
T
C
D
--
P
---
L
E
A
A
R
A
-
P
M
-
G
D
A
I
V
A
D
I
G
A
M
A
S
A
L
A
N
L
V
E
E
S
--
S
R
-
Q
L
P
T
A
A
P
E
-
P
A
K
V
D
Q
D
A
G
R
L
H
P
E
T
V
F
D
T
L
N
D
M
A
P
E
N
A
I
Y
L
N
E
S
T
S
T
T
A
-
Q
M
W
Q
R
L
N
M
R
-
N
P
G
S
Y
Y
F
CA
A
G
G
I
G
F
A
L
P
A
A
I
G
V
Q
-
L
A
----
E
-
P
E
R
Q
V
I
A
V
I
G
D
G
S
A
N
Y
S
I
S
A
L
W
T
A
A
Q
Y
N
I
P
T
I
F
V
I
M
N
N
G
T
Y
G
A
L
R
W
F
A
G
V
L
E
A
E
N
V
P
G
L
--
D
V
P
G
I
D
F
R
A
L
A
K
G
Y
G
V
Q
A
L
K
A
D
N
L
E
Q
L
K
G
S
L
Q
E
A
L
S
A
K
G
P
V
L
I
E
V
S
T
------------------------
11
PsiBlast_PDB
57.39
21%
-70
- C7 -
4MQ5
6
MDLC_PSEPU
A:
[10-523]
----------------
E
L
L
R
R
Q
G
I
D
T
V
F
G
N
P
G
S
N
E
L
P
F
L
K
D
F
P
E
D
--
F
R
Y
I
L
A
L
Q
E
A
C
V
V
G
I
A
D
G
Y
A
Q
A
S
R
K
P
A
F
I
N
L
H
S
A
A
G
T
G
N
A
M
G
A
L
S
N
A
W
N
S
H
S
P
L
I
V
T
A
G
Q
Q
T
R
A
M
I
G
V
E
A
L
L
T
N
V
D
A
A
N
L
P
R
P
L
V
K
W
S
Y
E
P
A
S
A
A
E
V
P
H
A
M
--------
S
R
A
I
H
M
A
S
M
A
P
Q
-
G
P
V
Y
L
S
V
P
Y
D
D
---------
W
D
K
D
A
D
---
P
Q
S
H
H
L
-
F
D
R
H
V
S
S
S
V
R
L
N
D
Q
D
---
L
D
I
L
V
K
A
-
L
N
S
A
S
N
P
A
I
V
L
G
P
D
V
D
A
A
N
A
N
A
D
C
V
M
L
A
E
R
L
K
A
P
V
W
V
A
P
S
A
-
P
R
C
P
F
P
-
T
R
H
P
C
F
R
G
L
M
P
A
G
I
--
A
A
I
S
Q
L
L
-
E
-
G
H
D
V
V
L
V
I
G
A
P
V
-------------
F
R
Y
H
Q
Y
D
P
G
--
Q
Y
L
K
P
G
T
R
L
I
S
--
V
T
C
D
P
L
E
A
F
R
A
P
M
G
D
A
-
I
V
A
D
I
G
A
M
A
S
A
L
A
N
L
V
--
E
E
S
S
R
Q
L
-------
P
T
A
A
P
E
-
P
A
K
V
D
Q
D
A
G
R
L
H
P
E
T
V
F
D
T
L
N
D
M
A
P
E
N
A
I
Y
L
N
E
S
T
S
T
T
A
-
Q
M
W
Q
R
L
N
M
R
-
N
P
G
S
Y
Y
F
CA
A
G
G
L
G
F
A
L
P
A
A
I
G
V
Q
-
L
A
----
E
-
P
E
R
Q
V
I
A
V
I
G
D
G
S
A
N
Y
S
I
S
A
L
W
T
A
A
Q
Y
N
I
P
T
I
F
V
I
M
N
N
G
T
Y
G
A
L
R
W
F
A
G
V
L
E
A
E
N
V
P
G
L
--
D
V
P
G
I
D
F
R
A
L
A
K
G
Y
G
V
Q
A
L
K
A
D
N
L
E
Q
L
K
G
S
L
Q
E
A
L
S
A
K
G
P
V
L
I
E
V
S
T
------------------------