@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : Lmo2212: (2016-04-01 )
MTKITNDLFLKAARKEQVDRIPVWYMRQAGRSQPEYRKLKEKYSLFEITHQPEICAYVTKLPVDQYGVDAAILYKDIMTPLPGMGVDVEIKSGIGPVIHNPIRSFQDVEKLTIFKPEIEVPYVLDTIKLLADDMLDVPLIGFAGAPFTLASYMIEGGPSKNYHQTKSFMYREPEVWAILMEKLGRMTANYLIAQINAGASAVQLFDSWVGALSRADYAEYIRPVIEMIVREVKAVHPTTPIIMQAVGASHLLEEWETMPLDVVGVDWRETITSARKKVPTKAIQGNLDPSTLLAPEKCLKEANRILQEGVLEPGYIFNLGHGVFPEVPPEMLKQLTNYIHERSEILLKKDDIK
Atome Classification :
(22 SA)
-.........10........20........30........-40.....-.-..50........60.....-...70........80........90........100.......110......-.---.120.......130...-.-...140.......150.......160.......170.......180.......190.......200.......210.......----220.......230..------.----..-----..240.......250.......260.......270......-.-280........290..-.....300...-.....310---........320.......330.......340.......350.
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
-MTKI
T
N
D
L
F
L
K
A
A
R
K
E
Q
VDRI
P
V
W
Y
M
R
Q
AGRS
Q
P
E
Y
R
K
L
-
K
E
KY
S
L
F
-
E
-ITHQP
E
I
C
A
Y
V
T
KLPVDQY-G
V
D
A
A
I
L
Y
K
D
I
MTPLPGM
G
V
D
V
E
IKSGI
G
P
V
I
H
N
P
I
R
S
F
Q
D
V
E
K
L
-
T
I
FKPE-I---EV
P
Y
V
L
D
T
I
K
L
L
A
D
DML-D-VPLIGFAGA
P
F
T
L
A
S
Y
M
IEGGPSKN
Y
H
Q
T
K
S
F
MYRE
P
E
V
W
A
I
L
M
E
K
L
G
R
M
T
A
N
Y
L
I
A
Q
INAG
A
S
A
V
Q
L
F
D
S
W
V
G
A
LSR
A
D
Y
A
E
----
Y
I
R
P
V
I
E
M
I
V
R
E
V
K
A------V----HP-----T
T
P
I
I
M
Q
A
V
G
A
S
H
L
L
E
E
WETMP
L
D
V
VGV
D
W
R
E
T
I
T
S
A
R
KKV-
P
-
T
K
-
A
IQGNL
D
P
S
TLL
A
-
P
E
K
C
L
K
E
-
A
N
R
-
I
L
Q
E
GVL----EPG
Y
I
F
NLGHGVFPEV
P
P
E
M
L
K
Q
L
T
N
Y
I
H
E
R
S
E
I
LLKKDDIK
28
HHSearch
98.61
65%
-120
- C3 -
2INF
-
DCUP_BACSU
A:
[6-348]
----
T
F
N
E
T
F
L
K
A
A
R
G
E
K
A
D
H
T
P
V
W
Y
M
R
Q
A
G
R
S
Q
P
E
Y
R
K
L
-
K
E
K
Y
G
L
F
-
E
-
I
T
H
Q
P
E
L
C
A
Y
V
T
R
L
P
V
E
Q
Y
-
G
V
D
A
A
I
L
Y
K
D
I
M
T
P
L
P
S
I
G
V
D
V
E
I
K
N
G
I
G
P
V
I
D
Q
P
I
R
S
L
A
D
I
E
K
L
-
G
Q
I
D
P
E
-
Q
---
D
V
P
Y
V
L
E
T
I
K
L
L
V
N
E
Q
L
-
N
-
V
P
L
I
G
F
S
G
A
P
F
T
L
A
S
Y
M
T
E
G
G
P
S
K
N
Y
N
K
T
K
A
F
M
Y
S
M
P
D
A
W
N
L
L
M
S
K
L
A
D
M
I
I
V
Y
V
K
A
Q
I
K
A
G
A
K
A
I
Q
I
F
D
S
W
V
G
A
L
N
Q
A
D
Y
R
T
----
Y
I
K
P
V
M
N
R
I
F
S
E
L
A
K
------
E
----
N
-------
V
P
L
I
M
F
G
V
G
A
S
H
L
A
G
D
W
H
D
L
P
L
D
V
V
G
L
D
W
R
L
G
I
D
E
A
R
S
K
--
G
I
T
K
-
T
V
Q
G
N
L
D
P
S
I
L
L
A
-
P
W
E
V
I
E
Q
K
T
K
E
-
I
L
D
Q
G
M
E
----
S
D
G
F
I
F
N
L
G
H
G
V
F
P
D
V
S
P
E
V
L
K
K
L
T
A
F
V
H
E
Y
S
Q
N
K
K
------
1
PsiBlast_PDB
97.19
65%
-118
- C3 -
2INF
-
DCUP_BACSU
A:
[8-345]
------
N
E
T
F
L
K
A
A
R
G
E
K
A
D
H
T
P
V
W
Y
M
R
Q
A
G
R
S
Q
P
E
Y
R
K
L
-
K
E
K
Y
G
L
F
-
E
-
I
T
H
Q
P
E
L
C
A
Y
V
T
R
L
P
V
E
Q
Y
-
G
V
D
A
A
I
L
Y
K
D
I
M
T
P
L
P
S
I
G
V
D
V
E
I
K
N
G
I
G
P
V
I
D
Q
P
I
R
S
L
A
D
I
E
K
L
-
G
Q
I
D
P
E
-
Q
---
D
V
P
Y
V
L
E
T
I
K
L
L
V
N
E
Q
L
-
N
-
V
P
L
I
G
F
S
G
A
P
F
T
L
A
S
Y
M
T
E
G
G
P
S
K
N
Y
N
K
T
K
A
F
M
Y
S
M
P
D
A
W
N
L
L
M
S
K
L
A
D
M
I
I
V
Y
V
K
A
Q
I
K
A
G
A
K
A
I
Q
I
F
D
S
W
V
G
A
L
N
Q
A
D
Y
R
T
----
Y
I
K
P
V
M
N
R
I
F
S
E
L
--------
A
----
K
E
-----
N
V
P
L
I
M
F
G
V
G
A
S
H
L
A
G
D
W
H
D
L
P
L
D
V
V
G
L
D
W
R
L
G
I
D
E
A
R
S
K
G
-
I
-
T
K
-
T
V
Q
G
N
L
D
P
S
I
L
L
A
-
P
W
E
V
I
E
Q
-
K
T
K
E
I
L
D
Q
G
M
E
----
S
D
G
F
I
F
N
L
G
H
G
V
F
P
D
V
S
P
E
V
L
K
K
L
T
A
F
V
H
E
Y
S
Q
---------
10
PsiBlast_PDB
87.91
36%
-107
- C3 -
1R3Q
2
DCUP_HUMAN
A:
[13-364]
---
E
L
K
N
D
T
F
L
R
A
A
W
G
E
E
T
D
Y
T
P
V
W
C
M
R
Q
A
G
R
Y
L
P
E
F
R
E
T
-
R
A
A
Q
D
F
F
-
S
-
T
C
R
S
P
E
A
C
C
E
L
T
L
Q
P
L
R
R
F
-
P
L
D
A
A
I
I
F
S
D
I
L
V
V
P
Q
A
L
G
M
E
V
T
M
V
P
G
K
G
P
S
F
P
E
P
L
R
E
E
Q
D
L
E
R
L
-
R
--
D
P
E
-
V
V
A
S
E
L
G
Y
V
F
Q
A
I
T
L
T
R
Q
R
L
A
-
G
R
V
P
L
I
G
F
A
G
A
P
W
T
L
M
T
Y
M
V
E
G
G
G
S
S
T
M
A
Q
A
K
R
W
L
Y
Q
R
P
Q
A
S
H
Q
L
L
R
I
L
T
D
A
L
V
P
Y
L
V
G
Q
V
V
A
G
A
Q
A
L
Q
L
F
E
S
H
A
G
H
L
G
P
Q
L
F
N
K
----
F
A
L
P
Y
I
R
D
V
A
K
Q
V
K
A
R
L
R
E
A
G
L
----
A
P
------
V
P
M
I
I
F
A
K
D
G
H
F
A
L
E
E
L
A
Q
A
G
Y
E
V
V
G
L
D
W
T
V
A
P
K
K
A
R
E
C
V
G
K
-
T
V
-
T
L
Q
G
N
L
D
P
C
A
L
Y
A
-
S
E
E
E
I
G
Q
-
L
V
K
-
Q
M
L
D
D
F
G
----
P
H
R
Y
I
A
N
L
G
H
G
L
Y
P
D
M
D
P
E
H
V
G
A
F
V
D
A
V
H
K
H
S
R
L
L
-------
49
Fugue
87.75
38%
-103
- C3 -
1J93
5
DCUP_TOBAC
A:
[11-353]
-----
T
Q
P
L
L
L
D
A
V
R
G
K
E
V
E
R
P
P
V
W
L
M
R
Q
A
G
R
Y
M
K
S
Y
Q
L
L
-
C
E
K
Y
P
L
F
R
D
-
R
S
E
N
V
D
L
V
V
E
I
S
L
Q
P
W
K
V
F
-
R
P
D
G
V
I
L
F
S
D
I
L
T
P
L
S
G
M
N
I
P
F
D
I
I
K
G
K
G
P
V
I
F
D
P
L
R
T
A
A
D
V
E
K
V
-
R
E
F
I
P
E
-
K
---
S
V
P
Y
V
G
E
A
L
T
I
L
R
K
E
V
N
N
Q
-
A
A
V
L
G
F
V
G
A
P
F
T
L
A
S
Y
V
V
E
G
G
S
S
K
N
F
T
K
I
K
R
L
A
F
A
E
P
K
V
L
H
A
L
L
Q
K
F
A
T
S
M
A
K
Y
I
R
Y
Q
A
D
S
G
A
Q
A
V
Q
I
F
D
S
W
A
T
E
L
S
P
V
D
F
E
E
----
F
S
L
P
Y
L
K
Q
I
V
D
S
V
K
L
------
T
----
H
P
-----
N
L
P
L
I
L
Y
A
S
G
S
G
G
L
L
E
R
L
P
L
T
G
V
D
V
V
S
L
D
W
T
V
D
M
A
D
G
R
R
R
L
G
P
-
N
V
-
A
I
Q
G
N
V
D
P
G
V
L
F
G
-
S
K
E
F
I
T
N
-
R
I
N
-
D
T
V
K
K
A
G
----
K
G
K
H
I
L
N
L
G
H
G
I
K
V
G
T
P
E
E
N
F
A
H
F
F
E
I
A
K
G
L
R
Y
---------
16
PsiBlast_PDB
87.71
36%
-105
- C3 -
1R3W
1
DCUP_HUMAN
A:
[13-364]
---
E
L
K
N
D
T
F
L
R
A
A
W
G
E
E
T
D
Y
T
P
V
W
C
M
R
Q
A
G
R
Y
L
P
E
F
R
E
T
-
R
A
A
Q
D
F
F
-
S
-
T
C
R
S
P
E
A
C
C
E
L
T
L
Q
P
L
R
R
F
-
P
L
D
A
A
I
I
F
S
D
I
L
V
V
P
Q
A
L
G
M
E
V
T
M
V
P
G
K
G
P
S
F
P
E
P
L
R
E
E
Q
D
L
E
R
L
-
R
--
D
P
E
-
V
V
A
S
E
L
G
Y
V
F
Q
A
I
T
L
T
R
Q
R
L
A
-
G
R
V
P
L
I
G
F
A
G
A
P
W
T
L
M
T
F
M
V
E
G
G
G
S
S
T
M
A
Q
A
K
R
W
L
Y
Q
R
P
Q
A
S
H
Q
L
L
R
I
L
T
D
A
L
V
P
Y
L
V
G
Q
V
V
A
G
A
Q
A
L
Q
L
F
E
S
H
A
G
H
L
G
P
Q
L
F
N
K
----
F
A
L
P
Y
I
R
D
V
A
K
Q
V
K
A
R
L
R
E
A
G
L
----
A
P
------
V
P
M
I
I
F
A
K
D
G
H
F
A
L
E
E
L
A
Q
A
G
Y
E
V
V
G
L
D
W
T
V
A
P
K
K
A
R
E
C
V
G
K
-
T
V
-
T
L
Q
G
N
L
D
P
C
A
L
Y
A
-
S
E
E
E
I
G
Q
-
L
V
K
-
Q
M
L
D
D
F
G
----
P
H
R
Y
I
A
N
L
G
H
G
L
Y
P
D
M
D
P
E
H
V
G
A
F
V
D
A
V
H
K
H
S
R
L
L
-------
48
Fugue
87.65
38%
-103
- C3 -
1J93
5
DCUP_TOBAC
A:
[11-353]
-----
T
Q
P
L
L
L
D
A
V
R
G
K
E
V
E
R
P
P
V
W
L
M
R
Q
A
G
R
Y
M
K
S
Y
Q
L
L
-
C
E
K
Y
P
L
F
-
R
D
R
S
E
N
V
D
L
V
V
E
I
S
L
Q
P
W
K
V
F
-
R
P
D
G
V
I
L
F
S
D
I
L
T
P
L
S
G
M
N
I
P
F
D
I
I
K
G
K
G
P
V
I
F
D
P
L
R
T
A
A
D
V
E
K
V
R
E
F
-
I
P
E
-
K
---
S
V
P
Y
V
G
E
A
L
T
I
L
R
K
E
V
N
N
Q
-
A
A
V
L
G
F
V
G
A
P
F
T
L
A
S
Y
V
V
E
G
G
S
S
K
N
F
T
K
I
K
R
L
A
F
A
E
P
K
V
L
H
A
L
L
Q
K
F
A
T
S
M
A
K
Y
I
R
Y
Q
A
D
S
G
A
Q
A
V
Q
I
F
D
S
W
A
T
E
L
S
P
V
D
F
E
E
----
F
S
L
P
Y
L
K
Q
I
V
D
S
V
K
L
------
T
----
H
P
-----
N
L
P
L
I
L
Y
A
S
G
S
G
G
L
L
E
R
L
P
L
T
G
V
D
V
V
S
L
D
W
T
V
D
M
A
D
G
R
R
R
L
G
P
-
N
V
-
A
I
Q
G
N
V
D
P
G
V
L
F
G
-
S
K
E
F
I
T
N
-
R
I
N
-
D
T
V
K
K
A
G
----
K
G
K
H
I
L
N
L
G
H
G
I
K
V
G
T
P
E
E
N
F
A
H
F
F
E
I
A
K
G
L
R
Y
---------
12
PsiBlast_PDB
87.60
36%
-105
- C3 -
3GVQ
-
DCUP_HUMAN
A:
[13-364]
---
E
L
K
N
D
T
F
L
R
A
A
W
G
E
E
T
D
Y
T
P
V
W
C
M
R
Q
A
G
R
Y
L
P
E
F
R
E
T
-
R
A
A
Q
D
F
F
-
S
-
T
C
R
S
P
E
A
C
C
E
L
T
L
Q
P
L
R
R
F
-
P
L
D
A
A
I
I
F
S
D
I
L
V
V
P
Q
A
L
G
M
E
V
T
M
V
P
G
K
G
P
S
F
P
E
P
L
R
E
E
Q
D
L
E
R
L
-
R
--
D
P
E
-
V
V
A
S
E
L
G
Y
V
F
Q
A
I
T
L
T
R
Q
R
L
A
-
G
R
V
P
L
I
G
F
A
G
A
P
W
T
L
M
T
Y
M
V
E
G
G
G
S
S
T
M
A
Q
A
K
R
W
L
Y
Q
R
P
Q
A
S
H
Q
L
L
R
I
L
T
D
A
L
V
P
Y
L
V
G
Q
V
V
A
G
A
Q
A
L
Q
L
F
E
S
H
A
G
H
L
G
P
Q
L
F
N
K
----
F
A
L
P
Y
I
R
D
V
A
K
Q
V
K
A
R
L
R
E
A
G
L
----
A
P
------
V
P
M
I
I
F
A
K
D
G
H
F
A
L
E
E
L
A
Q
A
G
Y
E
V
V
G
L
D
W
T
V
A
P
K
K
A
R
E
C
V
G
K
-
T
V
-
T
L
Q
G
N
L
D
P
C
A
L
Y
A
-
S
E
E
E
I
G
Q
-
L
V
K
-
Q
M
L
D
D
F
G
----
P
H
R
Y
I
A
N
L
G
H
G
L
Y
P
D
M
D
P
E
H
V
G
A
F
V
D
A
V
H
K
H
S
R
L
L
-------
8
PsiBlast_PDB
87.50
36%
-106
- C3 -
3GW0
-
DCUP_HUMAN
A:
[13-364]
---
E
L
K
N
D
T
F
L
R
A
A
W
G
E
E
T
D
Y
T
P
V
W
C
M
R
Q
A
G
R
Y
L
P
E
F
R
E
T
-
R
A
A
Q
D
F
F
-
S
-
T
C
R
S
P
E
A
C
C
E
L
T
L
Q
P
L
R
R
F
-
P
L
D
A
A
I
I
F
S
D
I
L
V
V
P
Q
A
L
G
M
E
V
T
M
V
P
G
K
G
P
S
F
P
E
P
L
R
E
E
Q
D
L
E
R
L
-
R
--
D
P
E
-
V
V
A
S
E
L
G
Y
V
F
Q
A
I
T
L
T
R
Q
R
L
A
-
G
R
V
P
L
I
G
F
A
G
A
P
W
T
L
M
T
Y
M
V
E
G
G
G
S
S
T
M
A
Q
A
K
R
W
L
Y
Q
R
P
Q
A
S
H
Q
L
L
R
I
L
T
D
A
L
V
P
Y
L
V
G
Q
V
V
A
G
A
Q
A
L
Q
L
F
E
S
H
A
G
H
L
G
P
Q
L
F
N
K
----
F
A
L
P
Y
I
R
D
V
A
K
Q
V
K
A
R
L
R
E
A
G
L
----
A
P
------
V
P
M
I
I
F
A
K
D
G
H
F
A
L
E
E
L
A
Q
A
G
Y
E
V
V
G
L
D
W
T
V
A
P
K
K
A
R
E
C
V
G
K
-
T
V
-
T
L
Q
G
N
L
D
P
C
A
L
Y
A
-
S
E
E
E
I
R
Q
-
L
V
K
-
Q
M
L
D
D
F
G
----
P
H
R
Y
I
A
N
L
G
H
G
L
Y
P
D
M
D
P
E
H
V
G
A
F
V
D
A
V
H
K
H
S
R
L
L
-------
26
HHSearch
87.49
37%
-105
- C3 -
1R3S
1
DCUP_HUMAN
A:
[11-366]
-
F
P
E
L
K
N
D
T
F
L
R
A
A
W
G
E
E
T
D
Y
T
P
V
W
C
M
R
Q
A
G
R
Y
L
P
E
F
R
E
T
-
R
A
A
Q
D
F
F
-
S
-
T
C
R
S
P
E
A
C
C
E
L
T
L
Q
P
L
R
R
F
-
P
L
D
A
A
I
I
F
S
G
I
L
V
V
P
Q
A
L
G
M
E
V
T
M
V
P
G
K
G
P
S
F
P
E
P
L
R
E
E
Q
D
L
E
R
L
-
R
D
P
E
V
V
A
S
---
E
L
G
Y
V
F
Q
A
I
T
L
T
R
Q
R
L
A
-
G
R
V
P
L
I
G
F
A
G
A
P
W
T
L
M
T
Y
M
V
E
G
G
G
S
S
T
M
A
Q
A
K
R
W
L
Y
Q
R
P
Q
A
S
H
Q
L
L
R
I
L
T
D
A
L
V
P
Y
L
V
G
Q
V
V
A
G
A
Q
A
L
Q
L
F
E
S
H
A
G
H
L
G
P
Q
L
F
N
K
----
F
A
L
P
Y
I
R
D
V
A
K
Q
V
K
A
------
R
L
R
E
A
G
L
A
----
P
V
P
M
I
I
F
A
K
D
G
H
F
A
L
E
E
L
A
Q
A
G
Y
E
V
V
G
L
D
W
T
V
A
P
K
K
A
R
E
C
V
-
G
K
T
V
-
T
L
Q
G
N
L
D
P
C
A
L
Y
A
-
S
E
E
E
I
G
Q
L
V
K
Q
-
M
L
D
D
F
G
-----
P
H
R
Y
I
A
N
L
G
H
G
L
Y
P
D
M
D
P
E
H
V
G
A
F
V
D
A
V
H
K
H
S
R
L
L
R
Q
-----
19
PsiBlast_PDB
87.45
36%
-105
- C3 -
1R3R
-
DCUP_HUMAN
A:
[13-364]
---
E
L
K
N
D
T
F
L
R
A
A
W
G
E
E
T
D
Y
T
P
V
W
C
M
R
Q
A
G
R
Y
L
P
E
F
R
E
T
-
R
A
A
Q
D
F
F
-
S
-
T
C
R
S
P
E
A
C
C
E
L
T
L
Q
P
L
R
R
F
-
P
L
D
A
A
I
I
F
S
N
I
L
V
V
P
Q
A
L
G
M
E
V
T
M
V
P
G
K
G
P
S
F
P
E
P
L
R
E
E
Q
D
L
E
R
L
-
R
--
D
P
E
-
V
V
A
S
E
L
G
Y
V
F
Q
A
I
T
L
T
R
Q
R
L
A
-
G
R
V
P
L
I
G
F
A
G
A
P
W
T
L
M
T
Y
M
V
E
G
G
G
S
S
T
M
A
Q
A
K
R
W
L
Y
Q
R
P
Q
A
S
H
Q
L
L
R
I
L
T
D
A
L
V
P
Y
L
V
G
Q
V
V
A
G
A
Q
A
L
Q
L
F
E
S
H
A
G
H
L
G
P
Q
L
F
N
K
----
F
A
L
P
Y
I
R
D
V
A
K
Q
V
K
A
R
L
R
E
A
G
L
----
A
P
------
V
P
M
I
I
F
A
K
D
G
H
F
A
L
E
E
L
A
Q
A
G
Y
E
V
V
G
L
D
W
T
V
A
P
K
K
A
R
E
C
V
G
K
-
T
V
-
T
L
Q
G
N
L
D
P
C
A
L
Y
A
-
S
E
E
E
I
G
Q
-
L
V
K
-
Q
M
L
D
D
F
G
----
P
H
R
Y
I
A
N
L
G
H
G
L
Y
P
D
M
D
P
E
H
V
G
A
F
V
D
A
V
H
K
H
S
R
L
L
-------
5
PsiBlast_PDB
87.42
37%
-108
- C3 -
4ZR8
6
?
A:
[11-360]
---
T
L
K
N
D
R
F
L
R
A
L
L
R
E
P
V
D
T
T
P
I
W
M
M
R
Q
A
G
R
Y
L
P
E
Y
R
E
T
-
R
S
K
A
G
--L
S
-
L
C
K
N
T
E
F
A
C
E
V
T
L
Q
P
L
R
R
Y
-
D
L
D
A
A
I
L
F
S
D
I
L
T
I
P
D
A
L
G
L
G
L
Y
F
E
T
G
E
G
P
K
F
H
K
T
V
R
T
E
Q
D
V
A
N
L
-
P
K
L
N
A
K
-
A
---
D
L
D
Y
V
M
N
A
V
S
T
I
R
S
A
L
G
G
Q
-
V
P
L
I
G
F
S
G
S
P
W
T
L
A
T
Y
M
V
E
G
G
S
S
K
E
F
R
F
T
K
Q
M
M
Y
A
Q
P
E
V
L
H
A
L
L
D
H
L
A
D
S
V
I
D
Y
L
N
A
Q
I
D
A
G
A
Q
A
I
Q
I
F
D
S
W
G
G
A
L
A
H
R
E
Y
V
E
FS
L
N
Y
M
K
K
I
I
A
G
L
Q
R
E
K
D
G
------
R
----
R
-------
I
P
V
I
V
F
T
K
G
G
G
Q
W
L
E
P
M
I
T
T
G
A
D
A
L
G
L
D
W
T
T
P
L
N
T
A
R
T
T
V
-
A
-
G
R
V
A
L
Q
G
N
L
D
P
A
V
L
Y
G
-
S
A
A
S
I
E
K
-
A
V
K
-
A
M
L
D
D
A
Y
ANGE
K
T
G
Y
V
A
N
L
G
H
G
I
T
Q
W
V
D
P
A
Q
P
K
I
F
V
D
T
V
H
E
Y
S
----------
21
PsiBlast_CBE
87.40
40%
-103
- C3 -
4WSH
3
DCUP_PSEAE
B:
[11-358]
---
A
L
K
N
D
R
F
L
R
A
L
L
K
Q
P
V
D
V
T
P
V
W
M
M
R
Q
A
G
R
Y
L
P
E
Y
R
A
T
-
R
A
K
A
G
D
F
M
S
-
L
C
M
N
P
E
L
A
C
E
V
T
L
Q
P
L
D
R
Y
P
Q
L
D
A
A
I
L
F
S
D
I
L
T
I
P
D
A
M
G
Q
G
L
Y
------
P
R
F
R
K
V
V
S
S
L
A
D
I
E
A
L
-
P
V
P
D
P
E
-
Q
---
D
L
G
Y
V
M
D
A
V
R
T
I
R
R
E
L
N
-
G
R
V
P
L
I
G
F
S
G
S
P
W
T
L
A
T
Y
M
V
E
G
G
S
S
K
D
F
R
K
S
K
A
M
L
Y
D
N
P
K
A
M
H
A
L
L
D
K
L
A
Q
S
V
T
S
Y
L
N
G
Q
I
H
A
G
A
Q
A
V
Q
I
F
D
S
W
G
G
S
L
S
A
A
A
Y
Q
E
FS
L
A
Y
M
R
K
I
V
D
G
L
I
R
E
H
D
G
------
R
----
R
-------
V
P
V
I
L
F
T
K
G
G
G
L
W
L
E
S
M
A
E
V
G
A
E
A
L
G
L
D
W
T
C
D
I
G
S
A
R
A
R
V
-
G
-
E
R
V
A
L
Q
G
N
M
D
P
S
V
L
Y
A
N
P
A
A
I
R
A
E
-
V
A
R
-
I
L
A
A
Y
G
K
----
G
T
G
H
V
F
N
L
G
H
G
I
T
P
E
V
D
P
A
H
A
G
A
F
F
E
A
V
H
E
L
S
----------
24
PsiBlast_CBE
87.33
36%
-107
- C3 -
1R3S
1
DCUP_HUMAN
A:
[13-364]
---
E
L
K
N
D
T
F
L
R
A
A
W
G
E
E
T
D
Y
T
P
V
W
C
M
R
Q
A
G
R
Y
L
P
E
F
R
E
T
-
R
A
A
Q
D
F
F
-
S
-
T
C
R
S
P
E
A
C
C
E
L
T
L
Q
P
L
R
R
F
-
P
L
D
A
A
I
I
F
S
G
I
L
V
V
P
Q
A
L
G
M
E
V
T
M
V
P
G
K
G
P
S
F
P
E
P
L
R
E
E
Q
D
L
E
R
L
-
R
--
D
P
E
-
V
V
A
S
E
L
G
Y
V
F
Q
A
I
T
L
T
R
Q
R
L
A
-
G
R
V
P
L
I
G
F
A
G
A
P
W
T
L
M
T
Y
M
V
E
G
G
G
S
S
T
M
A
Q
A
K
R
W
L
Y
Q
R
P
Q
A
S
H
Q
L
L
R
I
L
T
D
A
L
V
P
Y
L
V
G
Q
V
V
A
G
A
Q
A
L
Q
L
F
E
S
H
A
G
H
L
G
P
Q
L
F
N
K
----
F
A
L
P
Y
I
R
D
V
A
K
Q
V
K
A
R
L
R
E
A
G
L
----
A
P
------
V
P
M
I
I
F
A
K
D
G
H
F
A
L
E
E
L
A
Q
A
G
Y
E
V
V
G
L
D
W
T
V
A
P
K
K
A
R
E
C
V
G
K
-
T
V
-
T
L
Q
G
N
L
D
P
C
A
L
Y
A
-
S
E
E
E
I
G
Q
-
L
V
K
-
Q
M
L
D
D
F
G
----
P
H
R
Y
I
A
N
L
G
H
G
L
Y
P
D
M
D
P
E
H
V
G
A
F
V
D
A
V
H
K
H
S
R
L
L
-------
11
PsiBlast_PDB
87.26
36%
-108
- C3 -
1R3Y
1
DCUP_HUMAN
A:
[13-364]
---
E
L
K
N
D
T
F
L
R
A
A
W
G
E
E
T
D
Y
T
P
V
W
C
M
R
Q
A
G
R
Y
L
P
E
F
R
E
T
-
R
A
A
Q
D
F
F
-
S
-
T
C
R
S
P
E
A
C
C
E
L
T
L
Q
P
L
R
R
F
-
P
L
D
A
A
I
I
F
S
D
I
L
V
V
P
Q
A
L
G
M
E
V
T
M
V
P
G
K
G
P
S
F
P
E
P
L
R
E
E
Q
D
L
E
R
L
-
R
--
D
P
E
-
V
V
A
S
E
L
G
Y
V
F
Q
A
I
T
L
T
R
Q
R
L
A
-
G
R
V
P
L
I
G
F
A
G
A
P
W
T
L
M
T
Y
M
V
E
G
G
G
S
S
T
M
A
Q
A
K
R
W
L
Y
Q
R
P
Q
A
S
H
Q
L
L
R
I
L
T
D
A
L
V
P
Y
L
V
G
Q
V
V
A
G
A
Q
A
L
Q
L
F
E
S
H
A
G
H
L
G
P
Q
L
F
N
K
----
F
A
L
P
Y
I
R
D
V
A
K
Q
V
K
A
R
L
R
E
A
G
L
----
A
P
------
V
P
M
I
I
F
A
K
D
G
H
F
A
L
E
E
L
A
Q
A
G
Y
E
V
V
G
L
D
W
T
V
A
P
K
K
A
R
E
C
V
G
K
-
T
V
-
T
L
Q
G
N
L
D
P
C
A
L
Y
A
-
S
E
E
E
I
G
Q
-
L
V
K
-
Q
M
L
D
D
F
G
----
P
H
R
Y
I
A
N
L
G
H
G
L
Y
P
D
M
D
P
E
H
V
G
A
F
V
D
A
V
H
K
H
S
R
L
L
-------
23
PsiBlast_CBE
87.19
36%
-106
- C3 -
1R3T
1
DCUP_HUMAN
A:
[13-364]
---
E
L
K
N
D
T
F
L
R
A
A
W
G
E
E
T
D
Y
T
P
V
W
C
M
R
Q
A
G
R
Y
L
P
E
F
R
E
T
-
R
A
A
Q
D
F
F
-
S
-
T
C
R
S
P
E
A
C
C
E
L
T
L
Q
P
L
R
R
F
-
P
L
D
A
A
I
I
F
S
G
I
L
V
V
P
Q
A
L
G
M
E
V
T
M
V
P
G
K
G
P
S
F
P
E
P
L
R
E
E
Q
D
L
E
R
L
-
R
--
D
P
E
-
V
V
A
S
E
L
G
Y
V
F
Q
A
I
T
L
T
R
Q
R
L
A
-
G
R
V
P
L
I
G
F
A
G
A
P
W
T
L
M
T
Y
M
V
E
G
G
G
S
S
T
M
A
Q
A
K
R
W
L
Y
Q
R
P
Q
A
S
H
Q
L
L
R
I
L
T
D
A
L
V
P
Y
L
V
G
Q
V
V
A
G
A
Q
A
L
Q
L
F
E
S
H
A
G
H
L
G
P
Q
L
F
N
K
----
F
A
L
P
Y
I
R
D
V
A
K
Q
V
K
A
R
L
R
E
A
G
L
----
A
P
------
V
P
M
I
I
F
A
K
D
G
H
F
A
L
E
E
L
A
Q
A
G
Y
E
V
V
G
L
D
W
T
V
A
P
K
K
A
R
E
C
V
G
K
-
T
V
-
T
L
Q
G
N
L
D
P
C
A
L
Y
A
-
S
E
E
E
I
G
Q
-
L
V
K
-
Q
M
L
D
D
F
G
----
P
H
R
Y
I
A
N
L
G
H
G
L
Y
P
D
M
D
P
E
H
V
G
A
F
V
D
A
V
H
K
H
S
R
L
L
-------
20
PsiBlast_PDB
87.03
36%
-106
- C3 -
1R3V
2
DCUP_HUMAN
A:
[13-364]
---
E
L
K
N
D
T
F
L
R
A
A
W
G
E
E
T
D
Y
T
P
V
W
C
M
R
Q
A
G
R
Y
L
P
E
F
R
E
T
-
R
A
A
Q
D
F
F
-
S
-
T
C
R
S
P
E
A
C
C
E
L
T
L
Q
P
L
R
R
F
-
P
L
D
A
A
I
I
F
S
E
I
L
V
V
P
Q
A
L
G
M
E
V
T
M
V
P
G
K
G
P
S
F
P
E
P
L
R
E
E
Q
D
L
E
R
L
-
R
--
D
P
E
-
V
V
A
S
E
L
G
Y
V
F
Q
A
I
T
L
T
R
Q
R
L
A
-
G
R
V
P
L
I
G
F
A
G
A
P
W
T
L
M
T
Y
M
V
E
G
G
G
S
S
T
M
A
Q
A
K
R
W
L
Y
Q
R
P
Q
A
S
H
Q
L
L
R
I
L
T
D
A
L
V
P
Y
L
V
G
Q
V
V
A
G
A
Q
A
L
Q
L
F
E
S
H
A
G
H
L
G
P
Q
L
F
N
K
----
F
A
L
P
Y
I
R
D
V
A
K
Q
V
K
A
R
L
R
E
A
G
L
----
A
P
------
V
P
M
I
I
F
A
K
D
G
H
F
A
L
E
E
L
A
Q
A
G
Y
E
V
V
G
L
D
W
T
V
A
P
K
K
A
R
E
C
V
G
K
-
T
V
-
T
L
Q
G
N
L
D
P
C
A
L
Y
A
-
S
E
E
E
I
G
Q
-
L
V
K
-
Q
M
L
D
D
F
G
----
P
H
R
Y
I
A
N
L
G
H
G
L
Y
P
D
M
D
P
E
H
V
G
A
F
V
D
A
V
H
K
H
S
R
L
L
-------
27
HHSearch
86.96
36%
-103
- C3 -
1J93
5
DCUP_TOBAC
A:
[11-353]
-----
T
Q
P
L
L
L
D
A
V
R
G
K
E
V
E
R
P
P
V
W
L
M
R
Q
A
G
R
Y
M
K
S
Y
Q
L
L
C
E
K
Y
P
L
F
R
-
D
-
R
S
E
N
V
D
L
V
V
E
I
S
L
Q
P
W
K
V
F
-
R
P
D
G
V
I
L
F
S
D
I
L
T
P
L
S
G
M
N
I
P
F
D
I
I
K
G
K
G
P
V
I
F
D
P
L
R
T
A
A
D
V
E
K
V
-
R
E
F
I
P
E
-
K
---
S
V
P
Y
V
G
E
A
L
T
I
L
R
K
E
V
N
-
N
Q
A
A
V
L
G
F
V
G
A
P
F
T
L
A
S
Y
V
V
E
G
G
S
S
K
N
F
T
K
I
K
R
L
A
F
A
E
P
K
V
L
H
A
L
L
Q
K
F
A
T
S
M
A
K
Y
I
R
Y
Q
A
D
S
G
A
Q
A
V
Q
I
F
D
S
W
A
T
E
L
S
P
V
D
F
E
E
----
F
S
L
P
Y
L
K
Q
I
V
D
S
V
K
L
------
T
----
H
P
-----
N
L
P
L
I
L
Y
A
S
G
S
G
G
L
L
E
R
L
P
L
T
G
V
D
V
V
S
L
D
W
T
V
D
M
A
D
G
R
R
R
L
-
G
P
N
V
-
A
I
Q
G
N
V
D
P
G
V
L
F
G
-
S
K
E
F
I
T
N
R
I
N
D
-
T
V
K
K
A
G
-----
K
G
K
H
I
L
N
L
G
H
G
I
K
V
G
T
P
E
E
N
F
A
H
F
F
E
I
A
K
G
L
R
Y
---------
47
Fugue
86.94
36%
-101
- C3 -
1URO
1
DCUP_HUMAN
A:
[10-366]
G
F
P
E
L
K
N
D
T
F
L
R
A
A
W
G
E
E
T
D
Y
T
P
V
W
C
M
R
Q
A
G
R
Y
L
P
E
F
R
E
T
-
R
A
A
Q
D
F
F
-
S
-
T
C
R
S
P
E
A
C
C
E
L
T
L
Q
P
L
R
R
F
-
P
L
D
A
A
I
I
F
S
D
I
L
V
V
P
Q
A
L
G
M
E
V
T
M
V
P
G
K
G
P
S
F
P
E
P
L
R
E
E
Q
D
L
E
R
L
R
D
P
E
V
V
A
-
S
---
E
L
G
Y
V
F
Q
A
I
T
L
T
R
Q
R
L
A
G
R
-
V
P
L
I
G
F
A
G
A
P
W
T
L
M
T
Y
M
V
E
G
G
G
S
S
T
M
A
Q
A
K
R
W
L
Y
Q
R
P
Q
A
S
H
Q
L
L
R
I
L
T
D
A
L
V
P
Y
L
V
G
Q
V
V
A
G
A
Q
A
L
Q
L
F
E
S
H
A
G
H
L
G
P
Q
L
F
N
K
----
F
A
L
P
Y
I
R
D
V
A
K
Q
V
K
A
------
R
----
L
R
E
A
G
L
A
P
V
P
M
I
I
F
A
K
D
G
H
F
A
L
E
E
L
A
Q
A
G
Y
E
V
V
G
L
D
W
T
V
A
P
K
K
A
R
E
C
V
G
K
-
T
V
-
T
L
Q
G
N
L
D
P
C
A
L
Y
A
-
S
E
E
E
I
G
Q
-
L
V
K
-
Q
M
L
D
D
F
G
----
P
H
R
Y
I
A
N
L
G
H
G
L
Y
P
D
M
D
P
E
H
V
G
A
F
V
D
A
V
H
K
H
S
R
L
L
R
Q
-----
2
PsiBlast_PDB
86.94
40%
-105
- C3 -
4WSH
8
DCUP_PSEAE
A:
[9-358]
-
M
T
A
L
K
N
D
R
F
L
R
A
L
L
K
Q
P
V
D
V
T
P
V
W
M
M
R
Q
A
G
R
Y
L
P
E
Y
R
A
T
-
R
A
K
A
G
D
F
M
S
-
L
C
M
N
P
E
L
A
C
E
V
T
L
Q
P
L
D
R
Y
P
Q
L
D
A
A
I
L
F
S
D
I
L
T
I
P
D
A
M
G
Q
G
L
Y
F
E
T
G
E
G
P
R
F
R
K
V
V
S
S
L
A
D
I
E
A
L
-
P
V
P
D
P
E
-
Q
---
D
L
G
Y
V
M
D
A
V
R
T
I
R
R
E
L
N
-
G
R
V
P
L
I
G
F
S
G
S
P
W
T
L
A
T
Y
M
V
E
G
G
S
S
K
D
F
R
K
S
K
A
M
L
Y
D
N
P
K
A
M
H
A
L
L
D
K
L
A
Q
S
V
T
S
Y
L
N
G
Q
I
H
A
G
A
Q
A
V
Q
I
F
D
S
W
G
G
S
L
S
A
A
A
Y
Q
E
FS
L
A
Y
M
R
K
I
V
D
G
L
I
R
E
H
D
G
------
R
----
R
-------
V
P
V
I
L
F
T
K
G
G
G
L
W
L
E
S
M
A
E
V
G
A
E
A
L
G
L
D
W
T
C
D
I
G
S
A
R
A
R
V
-
G
-
E
R
V
A
L
Q
G
N
M
D
P
S
V
L
Y
A
N
P
A
A
I
R
A
E
-
V
A
R
-
I
L
A
A
Y
G
K
----
G
T
G
H
V
F
N
L
G
H
G
I
T
P
E
V
D
P
A
H
A
G
A
F
F
E
A
V
H
E
L
S
----------
17
PsiBlast_PDB
86.86
36%
-106
- C3 -
3GVV
-
DCUP_HUMAN
A:
[13-364]
---
E
L
K
N
D
T
F
L
R
A
A
W
G
E
E
T
D
Y
T
P
V
W
C
M
R
Q
A
G
R
Y
L
P
E
F
R
E
T
-
R
A
A
Q
D
F
F
-
S
-
T
C
R
S
P
E
A
C
C
E
L
T
L
Q
P
L
R
R
F
-
P
L
D
A
A
I
I
F
S
D
I
L
V
V
P
Q
A
L
G
M
E
V
T
M
V
P
G
K
G
P
S
F
P
E
P
L
R
E
E
Q
D
L
E
R
L
-
R
--
D
P
E
-
V
V
A
S
E
L
G
Y
V
F
Q
A
I
T
L
T
R
Q
R
L
A
-
G
R
V
P
L
I
G
F
A
G
A
P
W
T
L
M
T
Y
M
V
E
G
G
G
S
S
T
M
A
Q
A
K
R
W
L
Y
Q
R
P
Q
A
S
H
Q
L
L
R
I
L
T
D
A
L
V
P
Y
L
V
G
Q
V
V
A
G
A
Q
A
L
Q
L
Y
E
S
H
A
G
H
L
G
P
Q
L
F
N
K
----
F
A
L
P
Y
I
R
D
V
A
K
Q
V
K
A
R
L
R
E
A
G
L
----
A
P
------
V
P
M
I
I
F
A
K
D
G
H
F
A
L
E
E
L
A
Q
A
G
Y
E
V
V
G
L
D
W
T
V
A
P
K
K
A
R
E
C
V
G
K
-
T
V
-
T
L
Q
G
N
L
D
P
C
A
L
Y
A
-
S
E
E
E
I
G
Q
-
L
V
K
-
Q
M
L
D
D
F
G
----
P
H
R
Y
I
A
N
L
G
H
G
L
Y
P
D
M
D
P
E
H
V
G
A
F
V
D
A
V
H
K
H
S
R
L
L
-------
25
PsiBlast_CBE
86.51
36%
-107
- C3 -
2Q71
1
DCUP_HUMAN
A:
[3-354]
---
E
L
K
N
D
T
F
L
R
A
A
W
G
E
E
T
D
Y
T
P
V
W
C
M
R
Q
A
G
R
Y
L
P
E
F
R
E
T
-
R
A
A
Q
D
F
F
-
S
-
T
C
R
S
P
E
A
C
C
E
L
T
L
Q
P
L
R
R
F
-
P
L
D
A
A
I
I
F
S
D
I
L
V
V
P
Q
A
L
G
M
E
V
T
M
V
P
G
K
G
P
S
F
P
E
P
L
R
E
E
Q
D
L
E
R
L
-
R
--
D
P
E
-
V
V
A
S
E
L
G
Y
V
F
Q
A
I
T
L
T
R
Q
R
L
A
-
G
R
V
P
L
I
G
F
A
G
A
P
W
T
L
M
T
Y
M
V
E
R
G
G
S
S
T
M
A
Q
A
K
R
W
L
Y
Q
R
P
Q
A
S
H
Q
L
L
R
I
L
T
D
A
L
V
P
Y
L
V
G
Q
V
V
A
G
A
Q
A
L
Q
L
F
E
S
H
A
G
H
L
G
P
Q
L
F
N
K
----
F
A
L
P
Y
I
R
D
V
A
K
Q
V
K
A
R
L
R
E
A
G
L
----
A
P
------
V
P
M
I
I
F
A
K
D
G
H
F
A
L
E
E
L
A
Q
A
G
Y
E
V
V
G
L
D
W
T
V
A
P
K
K
A
R
E
C
V
G
K
-
T
V
-
T
L
Q
G
N
L
D
P
C
A
L
Y
A
-
S
E
E
E
I
G
Q
-
L
V
K
-
Q
M
L
D
D
F
G
----
P
H
R
Y
I
A
N
L
G
H
G
L
Y
P
D
M
D
P
E
H
V
G
A
F
V
D
A
V
H
K
H
S
R
L
L
-------
22
PsiBlast_CBE
86.23
37%
-105
- C3 -
4ZR8
5
?
B:
[12-360]
----
L
K
N
D
R
F
L
R
A
L
L
R
E
P
V
D
T
T
P
I
W
M
M
R
Q
A
G
R
Y
L
P
E
Y
R
E
T
-
R
S
K
A
G
D
F
L
S
-
L
C
K
N
T
E
F
A
C
E
V
T
L
Q
P
L
R
R
Y
-
D
L
D
A
A
I
L
F
S
D
I
L
T
I
P
D
A
L
G
L
G
L
Y
F
E
T
G
E
G
P
K
F
H
K
T
V
R
T
E
Q
D
V
A
N
L
-
P
K
L
N
A
K
-
A
---
D
L
D
Y
V
M
N
A
V
S
T
I
R
S
A
L
G
G
Q
-
V
P
L
I
G
F
S
G
S
P
W
T
L
A
T
Y
M
V
E
G
G
S
S
K
E
F
R
F
T
K
Q
M
M
Y
A
Q
P
E
V
L
H
A
L
L
D
H
L
A
D
S
V
I
D
Y
L
N
A
Q
I
D
A
G
A
Q
A
I
Q
I
F
D
S
W
G
G
A
L
A
H
R
E
Y
V
E
FS
L
N
Y
M
K
K
I
I
A
G
L
Q
R
E
K
D
G
------
R
----
R
-------
I
P
V
I
V
F
T
K
G
G
G
Q
W
L
E
P
M
I
T
T
G
A
D
A
L
G
L
D
W
T
T
P
L
N
T
A
R
T
T
V
-
A
-
G
R
V
A
L
Q
G
N
L
D
P
A
V
L
Y
G
-
S
A
A
S
I
E
K
-
A
V
K
-
A
M
L
D
D
A
Y
ANGE
K
T
G
Y
V
A
N
L
G
H
G
I
T
Q
W
V
D
P
A
Q
P
K
I
F
V
D
T
V
H
E
Y
S
----------