@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : Lmo2455: (2016-04-03 )
MSIITEVYAREVLDSRGNPTVEVEVYTEAGAFGRALVPSGASTGEYEAVELRDGDKARYLGKGVLKAVENVNDIIADKIIGFDVTDQIGIDKAMIELDGTPNKGKLGANAILGVSLAAARAAADELGVHLYEYLGGVNGKVLPVPMMNILNGGEHADNNVDVQEFMVMPVGAPNFKEALRMGAEILHALKAVLKGKGLNTGVGDEGGFAPNLKSNEEALETIMQAIKDAGYKPGEEVKLAMDAASSEFYNRETGKYELKGEGVTRTSEEMVTWYEEMITKYPIISIEDGLDENDWDGFKLLTERIGDRVQLVGDDLFVTNTTKLKEGIEKGIANSILIKVNQIGTLTETLDAIEMAKRAGYTAVISHRSGETEDSTIADIAVATNAGQIKTGAPTRTDRVAKYNQLLRIEDNLADLAEYHGNDTFYNLKK
Atome Classification :
(54 SA)
.........10........20........30----------........40-........50........60........70........80-.--........90........100.......110.......120.......130.---.....-----.---140---.-........150.......160.......170..---...---..180......----.190....--.--..-200........210.......220........230....-...240.......250..-----...---.--------.260------..-...------..-..270.......280.......290.......300.......310.......320.......330.......340.......350.......360.......370........380.......390.......400.......410.......420...-....430
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
M
S
I
I
T
E
V
Y
A
R
E
V
L
DSRGN
P
T
V
E
V
E
V
Y
TEAGA----------FGRALVPSGA-STGE
Y
E
A
V
E
LRDGD
K
A
R
Y
L
G
K
G
V
L
K
A
V
E
N
V
N
D
I
I
A
D
K
II--G--FDVTDQIGI
D
K
A
M
I
E
LDGTPNKGKLGAN
A
I
L
G
V
S
L
A
A
A
R
A
A
A
D
E
L
G
V
H
L
Y
E
Y
---LGGVN-----G---
K
-----
V
-
L
P
V
P
M
M
N
ILNGGEHADNNV
D
V
Q
E
F
M
V
MPVGAP
N
---
F
K
E
---
A
L
R
M
G
A
E
I
L
H
A
----
L
K
A
V
L
KGK--G--LN-TG-VGDEGGFAPNLKS
N
E
E
A
L
E
-
T
I
M
Q
A
I
K
DAGYKPG
E
E
-
V
K
L
A
M
DAASSEFYNRETG-----
K
Y
E
---
L
--------KG--------EG-VTR------
T
S
-
E
E
M
V
T
W
Y
E
E
M
I
T
KYP
I
I
S
IEDGLDENDW
D
G
F
K
L
L
T
E
RIGD
R
V
Q
L
VGD
D
L
F
VT
N
T
T
K
L
K
E
G
I
E
KGIA
N
S
I
L
I
K
VNQIG
T
L
T
E
T
L
D
A
I
E
M
A
K
RAG
Y
T
A
V
I
SHRSG-ETEDS
T
I
A
D
I
A
V
ATNAGQIKTGAPTR
T
D
R
V
A
K
Y
N
Q
L
L
R
IE
D
N
L
A
D
L
A
E
YHGNDTF-YNLKK
21
PsiBlast_CBE
94.10
81%
-67
- C1 -
4A3R
3
ENO_BACSU
D:
[1-428]
M
P
Y
I
V
D
V
Y
A
R
E
V
L
D
S
R
G
N
P
T
V
E
V
E
V
Y
T
E
T
G
A
----------
F
G
R
A
L
V
P
S
G
A
-
S
T
G
E
Y
E
A
V
E
L
R
D
G
D
K
D
R
Y
L
G
K
G
V
L
T
A
V
N
N
V
N
E
I
I
A
P
E
L
L
--
G
--
F
D
V
T
E
Q
N
A
I
D
Q
L
L
I
E
L
D
G
T
E
N
K
G
K
L
G
A
N
A
I
L
G
V
S
M
A
C
A
R
A
A
A
D
F
L
Q
I
P
L
Y
Q
Y
---
L
G
G
F
N
-----
S
---
K
-----
T
-
L
P
V
P
M
M
N
I
V
N
G
G
E
H
A
D
N
N
V
D
I
Q
E
F
M
I
M
P
V
G
A
P
N
---
F
R
E
---
A
L
R
M
G
A
Q
I
F
H
S
----
L
K
S
V
L
S
A
K
--
G
--
L
N
-
T
A
-
V
G
D
E
G
G
F
A
P
N
L
G
S
N
E
E
A
L
Q
-
T
I
V
E
A
I
E
K
A
G
F
K
P
G
E
E
-
V
K
L
A
M
D
A
A
S
S
E
F
Y
N
K
E
D
G
-----
K
Y
H
---
L
--------
S
G
--------
E
G
-
V
V
K
------
T
S
-
A
E
M
V
D
W
Y
E
E
L
V
S
K
Y
P
I
I
S
I
E
D
G
L
D
E
N
D
W
E
G
H
K
L
L
T
E
R
L
G
K
K
V
Q
L
V
G
D
D
L
F
V
T
N
T
K
K
L
S
E
G
I
K
N
G
V
G
N
S
I
L
I
K
V
N
Q
I
G
T
L
T
E
T
F
D
A
I
E
M
A
K
R
A
G
Y
T
A
V
I
S
H
R
S
G
-
E
T
E
D
S
T
I
A
D
I
A
V
A
T
N
A
G
Q
I
K
T
G
A
P
S
R
T
D
R
V
A
K
Y
N
Q
L
L
R
I
E
D
Q
L
A
E
T
A
Q
Y
H
G
I
N
S
F
-
Y
N
L
--
1
PsiBlast_PDB
94.03
81%
-68
- C1 -
4A3R
-
ENO_BACSU
A:
[1-428]
M
P
Y
I
V
D
V
Y
A
R
E
V
L
D
S
R
G
N
P
T
V
E
V
E
V
Y
T
E
T
G
A
----------
F
G
R
A
L
V
P
S
G
A
-
S
T
G
E
Y
E
A
V
E
L
R
D
G
D
K
D
R
Y
L
G
K
G
V
L
T
A
V
N
N
V
N
E
I
I
A
P
E
L
L
--
G
--
F
D
V
T
E
Q
N
A
I
D
Q
L
L
I
E
L
D
G
T
E
N
K
G
K
L
G
A
N
A
I
L
G
V
S
M
A
C
A
R
A
A
A
D
F
L
Q
I
P
L
Y
Q
Y
---
L
G
G
F
N
-----
S
---
K
-----
T
-
L
P
V
P
M
M
N
I
V
N
G
G
E
H
A
D
N
N
V
D
I
Q
E
F
M
I
M
P
V
G
A
P
N
---
F
R
E
---
A
L
R
M
G
A
Q
I
F
H
S
----
L
K
S
V
L
S
A
K
--
G
--
L
N
-
T
A
-
V
G
D
E
G
G
F
A
P
N
L
G
S
N
E
E
A
L
Q
-
T
I
V
E
A
I
E
K
A
G
F
K
P
G
E
E
-
V
K
L
A
M
D
A
A
S
S
E
F
Y
N
K
E
D
G
-----
K
Y
H
---
L
--------
S
G
--------
E
G
-
V
V
K
------
T
S
-
A
E
M
V
D
W
Y
E
E
L
V
S
K
Y
P
I
I
S
I
E
D
G
L
D
E
N
D
W
E
G
H
K
L
L
T
E
R
L
G
K
K
V
Q
L
V
G
D
D
L
F
V
T
N
T
K
K
L
S
E
G
I
K
N
G
V
G
N
S
I
L
I
K
V
N
Q
I
G
T
L
T
E
T
F
D
A
I
E
M
A
K
R
A
G
Y
T
A
V
I
S
H
R
S
G
-
E
T
E
D
S
T
I
A
D
I
A
V
A
T
N
A
G
Q
I
K
T
G
A
P
S
R
T
D
R
V
A
K
Y
N
Q
L
L
R
I
E
D
Q
L
A
E
T
A
Q
Y
H
G
I
N
S
F
-
Y
N
L
--
2
PsiBlast_PDB
93.04
77%
-69
- C1 -
1IYX
6
ENO_ENTHR
A:
[2-430]
-
S
I
I
T
D
V
Y
A
R
E
I
L
D
S
R
G
N
P
T
I
E
V
E
V
Y
T
E
S
G
A
----------
F
G
R
G
M
V
P
S
G
A
-
S
T
G
E
Y
E
A
V
E
L
R
D
G
D
K
A
R
Y
G
G
K
G
V
T
K
A
V
D
N
V
N
N
I
I
A
E
A
I
I
--
G
--
Y
D
V
R
D
Q
M
A
I
D
K
A
M
I
A
L
D
G
T
P
N
K
G
K
L
G
A
N
A
I
L
G
V
S
I
A
V
A
R
A
A
A
D
Y
L
E
V
P
L
Y
H
Y
---
L
G
G
F
N
-----
T
---
K
-----
V
-
L
P
T
P
M
M
N
I
I
N
G
G
S
H
A
D
N
S
I
D
F
Q
E
F
M
I
M
P
V
G
A
P
T
---
F
K
E
---
A
L
R
M
G
A
E
V
F
H
A
----
L
A
A
I
L
K
S
R
--
G
--
L
A
-
T
S
-
V
G
D
E
G
G
F
A
P
N
L
G
S
N
E
E
G
F
E
-
V
I
I
E
A
I
E
K
A
G
Y
V
P
G
K
D
-
V
V
L
A
M
D
A
A
S
S
E
F
Y
D
K
E
K
G
-----
V
Y
V
---
L
AD------
S
G
--------
E
G
--
E
K
------
T
T
-
D
E
M
I
K
F
Y
E
E
L
V
S
K
Y
P
I
I
S
I
E
D
G
L
D
E
N
D
W
D
G
F
K
K
L
T
D
V
L
G
D
K
V
Q
L
V
G
D
D
L
F
V
T
N
T
Q
K
L
S
E
G
I
E
K
G
I
A
N
S
I
L
I
K
V
N
Q
I
G
T
L
T
E
T
F
E
A
I
E
M
A
K
E
A
G
Y
T
A
V
V
S
H
R
S
G
-
E
T
E
D
S
T
I
S
D
I
A
V
A
T
N
A
G
Q
I
K
T
G
S
L
S
R
T
D
R
I
A
K
Y
N
Q
L
L
R
I
E
D
Q
L
G
E
V
A
E
Y
K
G
L
K
S
F
-
Y
N
L
K
-
22
PsiBlast_CBE
92.82
77%
-67
- C1 -
1IYX
5
ENO_ENTHR
B:
[2-430]
-
S
I
I
T
D
V
Y
A
R
E
I
L
D
S
R
G
N
P
T
I
E
V
E
V
Y
T
E
S
G
A
----------
F
G
R
G
M
V
P
S
G
A
-
S
T
G
E
Y
E
A
V
E
L
R
D
G
D
K
A
R
Y
G
G
K
G
V
T
K
A
V
D
N
V
N
N
I
I
A
E
A
I
I
--
G
--
Y
D
V
R
D
Q
M
A
I
D
K
A
M
I
A
L
D
G
T
P
N
K
G
K
L
G
A
N
A
I
L
G
V
S
I
A
V
A
R
A
A
A
D
Y
L
E
V
P
L
Y
H
Y
---
L
G
G
F
N
-----
T
---
K
-----
V
-
L
P
T
P
M
M
N
I
I
N
G
G
S
H
A
D
N
S
I
D
F
Q
E
F
M
I
M
P
V
G
A
P
T
---
F
K
E
---
A
L
R
M
G
A
E
V
F
H
A
----
L
A
A
I
L
K
S
R
--
G
--
L
A
-
T
S
-
V
G
D
E
G
G
F
A
P
N
L
G
S
N
E
E
G
F
E
-
V
I
I
E
A
I
E
K
A
G
Y
V
P
G
K
D
-
V
V
L
A
M
D
A
A
S
S
E
F
Y
D
K
E
K
G
-----
V
Y
V
---
L
AD------
S
G
--------
E
G
--
E
K
------
T
T
-
D
E
M
I
K
F
Y
E
E
L
V
S
K
Y
P
I
I
S
I
E
D
G
L
D
E
N
D
W
D
G
F
K
K
L
T
D
V
L
G
D
K
V
Q
L
V
G
D
D
L
F
V
T
N
T
Q
K
L
S
E
G
I
E
K
G
I
A
N
S
I
L
I
K
V
N
Q
I
G
T
L
T
E
T
F
E
A
I
E
M
A
K
E
A
G
Y
T
A
V
V
S
H
R
S
G
-
E
T
E
D
S
T
I
S
D
I
A
V
A
T
N
A
G
Q
I
K
T
G
S
L
S
R
T
D
R
I
A
K
Y
N
Q
L
L
R
I
E
D
Q
L
G
E
V
A
E
Y
K
G
L
K
S
F
-
Y
N
L
K
-
25
PsiBlast_CBE
91.46
71%
-65
- C1 -
3ZLF
2
ENO_STRP6
C:
[21-454]
M
S
I
I
T
D
V
Y
A
R
E
V
L
D
S
R
G
N
P
T
L
E
V
E
V
Y
T
E
S
G
A
----------
F
G
R
G
M
V
P
S
G
A
-
S
T
G
E
H
E
A
V
E
L
R
D
G
D
K
S
R
Y
L
G
L
G
T
Q
K
A
V
D
N
V
N
N
I
I
A
K
A
I
I
--
G
--
Y
D
V
R
D
Q
Q
A
I
D
R
A
M
I
A
L
D
G
T
P
N
K
G
K
L
G
A
N
A
I
L
G
V
S
I
A
V
A
R
A
A
A
D
Y
L
E
V
P
L
Y
T
Y
---
L
G
G
F
N
-----
T
---
K
-----
V
-
L
P
T
P
M
M
N
I
I
N
G
G
S
H
S
D
A
P
I
A
F
Q
E
F
M
I
M
P
V
G
A
P
T
---
F
K
E
---
G
L
R
W
G
A
E
V
F
H
A
----
L
K
K
I
L
K
E
R
--
G
--
L
V
-
T
A
-
V
G
D
E
G
G
F
A
P
K
F
E
G
T
E
D
G
V
E
-
T
I
L
K
A
I
E
A
A
G
Y
E
A
G
E
N
G
I
M
I
G
F
D
C
A
S
S
E
F
Y
D
K
E
R
K
-----
V
Y
D
YTK
F
--------
E
G
--------
E
G
A
A
V
R
------
T
S
-
A
E
Q
V
D
Y
L
E
E
L
V
N
K
Y
P
I
I
T
I
E
D
G
M
D
E
N
D
W
D
G
W
K
V
L
T
E
R
L
G
A
R
V
Q
L
V
G
D
D
F
F
V
T
N
T
E
Y
L
A
R
G
I
K
E
N
A
A
N
S
I
L
I
K
V
N
Q
I
G
T
L
T
E
T
F
E
A
I
E
M
A
K
E
A
G
Y
T
A
V
V
S
H
R
S
G
-
E
T
E
D
S
T
I
A
D
I
A
V
A
T
N
A
G
Q
I
K
T
G
S
L
S
R
T
D
R
I
A
K
Y
N
Q
L
L
R
I
E
D
Q
L
G
E
V
A
Q
Y
K
G
I
K
S
F
-
Y
N
L
K
-
29
PsiBlast_CBE
91.37
71%
-65
- C1 -
3ZLG
2
ENO_STRP6
C:
[21-453]
M
S
I
I
T
D
V
Y
A
R
E
V
L
D
S
R
G
N
P
T
L
E
V
E
V
Y
T
E
S
G
A
----------
F
G
R
G
M
V
P
S
G
A
-
S
T
G
E
H
E
A
V
E
L
R
D
G
D
K
S
R
Y
L
G
L
G
T
Q
K
A
V
D
N
V
N
N
I
I
A
K
A
I
I
--
G
--
Y
D
V
R
D
Q
Q
A
I
D
R
A
M
I
A
L
D
G
T
P
N
K
G
K
L
G
A
N
A
I
L
G
V
S
I
A
V
A
R
A
A
A
D
Y
L
E
V
P
L
Y
T
Y
---
L
G
G
F
N
-----
T
---
K
-----
V
-
L
P
T
P
M
M
N
I
I
N
G
G
S
H
S
D
A
P
I
A
F
Q
E
F
M
I
M
P
V
G
A
P
T
---
F
K
E
---
G
L
R
W
G
A
E
V
F
H
A
----
L
K
K
I
L
K
E
R
--
G
--
L
V
-
T
A
-
V
G
D
E
G
G
F
A
P
K
F
E
G
T
E
D
G
V
E
-
T
I
L
K
A
I
E
A
A
G
Y
E
A
G
E
N
G
I
M
I
G
F
D
C
A
S
S
E
F
Y
D
K
E
R
K
-----
V
Y
D
YTK
F
--------
E
G
--------
E
G
A
A
V
R
------
T
S
-
A
E
Q
V
D
Y
L
E
E
L
V
N
K
Y
P
I
I
T
I
E
D
G
M
D
E
N
D
W
D
G
W
K
V
L
T
E
R
L
G
K
R
V
Q
L
V
G
D
D
F
F
V
T
N
T
E
Y
L
A
R
G
I
K
E
N
A
A
N
S
I
L
I
K
V
N
Q
I
G
T
L
T
E
T
F
E
A
I
E
M
A
A
E
A
G
Y
T
A
V
V
S
H
R
S
G
-
E
T
E
D
S
T
I
A
D
I
A
V
A
T
N
A
G
Q
I
K
T
G
S
L
S
R
T
D
R
I
A
K
Y
N
Q
L
L
R
I
E
D
Q
L
G
E
V
A
Q
Y
K
G
I
K
S
F
-
Y
N
L
--
28
PsiBlast_CBE
91.27
71%
-66
- C1 -
3ZLG
2
ENO_STRP6
D:
[21-453]
M
S
I
I
T
D
V
Y
A
R
E
V
L
D
S
R
G
N
P
T
L
E
V
E
V
Y
T
E
S
G
A
----------
F
G
R
G
M
V
P
S
G
A
-
S
T
G
E
H
E
A
V
E
L
R
D
G
D
K
S
R
Y
L
G
L
G
T
Q
K
A
V
D
N
V
N
N
I
I
A
K
A
I
I
--
G
--
Y
D
V
R
D
Q
Q
A
I
D
R
A
M
I
A
L
D
G
T
P
N
K
G
K
L
G
A
N
A
I
L
G
V
S
I
A
V
A
R
A
A
A
D
Y
L
E
V
P
L
Y
T
Y
---
L
G
G
F
N
-----
T
---
K
-----
V
-
L
P
T
P
M
M
N
I
I
N
G
G
S
H
S
D
A
P
I
A
F
Q
E
F
M
I
M
P
V
G
A
P
T
---
F
K
E
---
G
L
R
W
G
A
E
V
F
H
A
----
L
K
K
I
L
K
E
R
--
G
--
L
V
-
T
A
-
V
G
D
E
G
G
F
A
P
K
F
E
G
T
E
D
G
V
E
-
T
I
L
K
A
I
E
A
A
G
Y
E
A
G
E
N
G
I
M
I
G
F
D
C
A
S
S
E
F
Y
D
K
E
R
K
-----
V
Y
D
YTK
F
--------
E
G
--------
E
G
A
A
V
R
------
T
S
-
A
E
Q
V
D
Y
L
E
E
L
V
N
K
Y
P
I
I
T
I
E
D
G
M
D
E
N
D
W
D
G
W
K
V
L
T
E
R
L
G
K
R
V
Q
L
V
G
D
D
F
F
V
T
N
T
E
Y
L
A
R
G
I
K
E
N
A
A
N
S
I
L
I
K
V
N
Q
I
G
T
L
T
E
T
F
E
A
I
E
M
A
A
E
A
G
Y
T
A
V
V
S
H
R
S
G
-
E
T
E
D
S
T
I
A
D
I
A
V
A
T
N
A
G
Q
I
K
T
G
S
L
S
R
T
D
R
I
A
K
Y
N
Q
L
L
R
I
E
D
Q
L
G
E
V
A
Q
Y
K
G
I
K
S
F
-
Y
N
L
--
24
PsiBlast_CBE
91.17
71%
-64
- C1 -
3ZLF
2
ENO_STRP6
D:
[21-453]
M
S
I
I
T
D
V
Y
A
R
E
V
L
D
S
R
G
N
P
T
L
E
V
E
V
Y
T
E
S
G
A
----------
F
G
R
G
M
V
P
S
G
A
-
S
T
G
E
H
E
A
V
E
L
R
D
G
D
K
S
R
Y
L
G
L
G
T
Q
K
A
V
D
N
V
N
N
I
I
A
K
A
I
I
--
G
--
Y
D
V
R
D
Q
Q
A
I
D
R
A
M
I
A
L
D
G
T
P
N
K
G
K
L
G
A
N
A
I
L
G
V
S
I
A
V
A
R
A
A
A
D
Y
L
E
V
P
L
Y
T
Y
---
L
G
G
F
N
-----
T
---
K
-----
V
-
L
P
T
P
M
M
N
I
I
N
G
G
S
H
S
D
A
P
I
A
F
Q
E
F
M
I
M
P
V
G
A
P
T
---
F
K
E
---
G
L
R
W
G
A
E
V
F
H
A
----
L
K
K
I
L
K
E
R
--
G
--
L
V
-
T
A
-
V
G
D
E
G
G
F
A
P
K
F
E
G
T
E
D
G
V
E
-
T
I
L
K
A
I
E
A
A
G
Y
E
A
G
E
N
G
I
M
I
G
F
D
C
A
S
S
E
F
Y
D
K
E
R
K
-----
V
Y
D
YTK
F
--------
E
G
--------
E
G
A
A
V
R
------
T
S
-
A
E
Q
V
D
Y
L
E
E
L
V
N
K
Y
P
I
I
T
I
E
D
G
M
D
E
N
D
W
D
G
W
K
V
L
T
E
R
L
G
A
R
V
Q
L
V
G
D
D
F
F
V
T
N
T
E
Y
L
A
R
G
I
K
E
N
A
A
N
S
I
L
I
K
V
N
Q
I
G
T
L
T
E
T
F
E
A
I
E
M
A
K
E
A
G
Y
T
A
V
V
S
H
R
S
G
-
E
T
E
D
S
T
I
A
D
I
A
V
A
T
N
A
G
Q
I
K
T
G
S
L
S
R
T
D
R
I
A
K
Y
N
Q
L
L
R
I
E
D
Q
L
G
E
V
A
Q
Y
K
G
I
K
S
F
-
Y
N
L
--
30
PsiBlast_CBE
91.01
71%
-66
- C1 -
3ZLG
2
ENO_STRP6
B:
[21-453]
M
S
I
I
T
D
V
Y
A
R
E
V
L
D
S
R
G
N
P
T
L
E
V
E
V
Y
T
E
S
G
A
----------
F
G
R
G
M
V
P
S
G
A
-
S
T
G
E
H
E
A
V
E
L
R
D
G
D
K
S
R
Y
L
G
L
G
T
Q
K
A
V
D
N
V
N
N
I
I
A
K
A
I
I
--
G
--
Y
D
V
R
D
Q
Q
A
I
D
R
A
M
I
A
L
D
G
T
P
N
K
G
K
L
G
A
N
A
I
L
G
V
S
I
A
V
A
R
A
A
A
D
Y
L
E
V
P
L
Y
T
Y
---
L
G
G
F
N
-----
T
---
K
-----
V
-
L
P
T
P
M
M
N
I
I
N
G
G
S
H
S
D
A
P
I
A
F
Q
E
F
M
I
M
P
V
G
A
P
T
---
F
K
E
---
G
L
R
W
G
A
E
V
F
H
A
----
L
K
K
I
L
K
E
R
--
G
--
L
V
-
T
A
-
V
G
D
E
G
G
F
A
P
K
F
E
G
T
E
D
G
V
E
-
T
I
L
K
A
I
E
A
A
G
Y
E
A
G
E
N
G
I
M
I
G
F
D
C
A
S
S
E
F
Y
D
K
E
R
K
-----
V
Y
D
YTK
F
--------
E
G
--------
E
G
A
A
V
R
------
T
S
-
A
E
Q
V
D
Y
L
E
E
L
V
N
K
Y
P
I
I
T
I
E
D
G
M
D
E
N
D
W
D
G
W
K
V
L
T
E
R
L
G
K
R
V
Q
L
V
G
D
D
F
F
V
T
N
T
E
Y
L
A
R
G
I
K
E
N
A
A
N
S
I
L
I
K
V
N
Q
I
G
T
L
T
E
T
F
E
A
I
E
M
A
A
E
A
G
Y
T
A
V
V
S
H
R
S
G
-
E
T
E
D
S
T
I
A
D
I
A
V
A
T
N
A
G
Q
I
K
T
G
S
L
S
R
T
D
R
I
A
K
Y
N
Q
L
L
R
I
E
D
Q
L
G
E
V
A
Q
Y
K
G
I
K
S
F
-
Y
N
L
--
5
PsiBlast_PDB
90.93
71%
-71
- C1 -
3ZLH
-
ENO_STRP6
A:
[21-453]
M
S
I
I
T
D
V
Y
A
R
E
V
L
D
S
R
G
N
P
T
L
E
V
E
V
Y
T
E
S
G
A
----------
F
G
R
G
M
V
P
S
-----
G
E
H
E
A
V
E
L
R
D
G
D
K
S
R
Y
L
G
L
G
T
Q
K
A
V
D
N
V
N
N
I
I
A
K
A
I
I
--
G
--
Y
D
V
R
D
Q
Q
A
I
D
R
A
M
I
A
L
D
G
T
P
N
K
G
K
L
G
A
N
A
I
L
G
V
S
I
A
V
A
R
A
A
A
D
Y
L
E
V
P
L
Y
T
Y
---
L
G
G
F
N
-----
T
---
K
-----
V
-
L
P
T
P
M
M
N
I
I
N
G
G
S
H
S
D
A
P
I
A
F
Q
E
F
M
I
M
P
V
G
A
P
T
---
F
K
E
---
G
L
R
W
G
A
E
V
F
H
A
----
L
K
K
I
L
K
E
R
--
G
--
L
V
-
T
A
-
V
G
D
E
G
G
F
A
P
K
F
E
G
T
E
D
G
V
E
-
T
I
L
K
A
I
E
A
A
G
Y
E
A
G
E
N
G
I
M
I
G
F
D
C
A
S
S
E
F
Y
D
K
E
R
K
-----
V
Y
D
YTK
F
--------
E
G
--------
E
G
A
A
V
R
------
T
S
-
A
E
Q
V
D
Y
L
E
E
L
V
N
K
Y
P
I
I
T
I
E
D
G
M
D
E
N
D
W
D
G
W
K
V
L
T
E
R
L
G
K
R
V
Q
L
V
G
D
D
F
F
V
T
N
T
E
Y
L
A
R
G
I
K
E
N
A
A
N
S
I
L
I
K
V
N
Q
I
G
T
L
T
E
T
F
E
A
I
E
M
A
K
E
A
G
Y
T
A
V
V
S
H
R
S
G
-
E
T
E
D
S
T
I
A
D
I
A
V
A
T
N
A
G
Q
I
K
T
G
S
L
S
R
T
D
R
I
A
K
Y
N
Q
L
L
R
I
E
D
Q
L
G
E
V
A
Q
Y
K
G
I
K
S
F
-
Y
N
L
--
26
PsiBlast_CBE
90.68
71%
-63
- C1 -
3ZLF
2
ENO_STRP6
B:
[21-453]
M
S
I
I
T
D
V
Y
A
R
E
V
L
D
S
R
G
N
P
T
L
E
V
E
V
Y
T
E
S
G
A
----------
F
G
R
G
M
V
P
S
G
A
-
S
T
G
E
H
E
A
V
E
L
R
D
G
D
K
S
R
Y
L
G
L
G
T
Q
K
A
V
D
N
V
N
N
I
I
A
K
A
I
I
--
G
--
Y
D
V
R
D
Q
Q
A
I
D
R
A
M
I
A
L
D
G
T
P
N
K
G
K
L
G
A
N
A
I
L
G
V
S
I
A
V
A
R
A
A
A
D
Y
L
E
V
P
L
Y
T
Y
---
L
G
G
F
N
-----
T
---
K
-----
V
-
L
P
T
P
M
M
N
I
I
N
G
G
S
H
S
D
A
P
I
A
F
Q
E
F
M
I
M
P
V
G
A
P
T
---
F
K
E
---
G
L
R
W
G
A
E
V
F
H
A
----
L
K
K
I
L
K
E
R
--
G
--
L
V
-
T
A
-
V
G
D
E
G
G
F
A
P
K
F
E
G
T
E
D
G
V
E
-
T
I
L
K
A
I
E
A
A
G
Y
E
A
G
E
N
G
I
M
I
G
F
D
C
A
S
S
E
F
Y
D
K
E
R
K
-----
V
Y
D
YTK
F
--------
E
G
--------
E
G
A
A
V
R
------
T
S
-
A
E
Q
V
D
Y
L
E
E
L
V
N
K
Y
P
I
I
T
I
E
D
G
M
D
E
N
D
W
D
G
W
K
V
L
T
E
R
L
G
A
R
V
Q
L
V
G
D
D
F
F
V
T
N
T
E
Y
L
A
R
G
I
K
E
N
A
A
N
S
I
L
I
K
V
N
Q
I
G
T
L
T
E
T
F
E
A
I
E
M
A
K
E
A
G
Y
T
A
V
V
S
H
R
S
G
-
E
T
E
D
S
T
I
A
D
I
A
V
A
T
N
A
G
Q
I
K
T
G
S
L
S
R
T
D
R
I
A
K
Y
N
Q
L
L
R
I
E
D
Q
L
G
E
V
A
Q
Y
K
G
I
K
S
F
-
Y
N
L
--
4
PsiBlast_PDB
90.52
71%
-68
- C1 -
4EWJ
-
?
A:
[1-433]
M
S
I
I
T
D
V
Y
A
R
E
V
L
D
S
R
G
N
P
T
L
E
V
E
V
Y
T
E
S
G
A
----------
F
G
R
G
M
V
P
S
G
----
G
E
H
E
A
V
E
L
R
D
G
D
K
S
R
Y
L
G
L
G
T
Q
K
A
V
D
N
V
N
N
V
I
A
D
A
I
I
--
G
--
F
D
V
R
D
Q
Q
A
I
D
R
A
M
I
A
L
D
G
T
P
N
K
G
K
L
G
A
N
A
I
L
G
V
S
I
A
V
A
R
A
A
A
D
Y
L
E
V
P
L
Y
T
Y
---
L
G
G
F
N
-----
T
---
K
-----
V
-
L
P
T
P
M
M
N
I
I
N
G
G
S
H
S
D
A
P
I
A
F
Q
E
F
M
I
L
P
V
G
A
P
S
---
F
K
E
---
G
L
R
W
G
A
E
V
F
H
A
----
L
K
K
I
L
K
A
R
--
G
--
L
V
-
T
A
-
V
G
D
E
G
G
F
A
P
K
F
E
G
T
E
D
G
V
E
-
T
I
I
E
A
I
E
A
A
G
Y
E
A
G
E
N
G
I
M
I
G
F
D
C
A
S
S
E
F
Y
D
--
R
K
-----
V
Y
D
YTK
F
--------
E
G
--------
E
G
A
A
V
R
------
T
S
-
A
E
Q
I
D
Y
L
E
E
L
V
N
K
Y
P
I
I
T
I
E
D
G
M
D
E
N
D
W
D
G
W
K
A
L
T
E
R
L
G
K
R
V
Q
L
V
G
D
D
F
F
V
T
N
T
D
Y
L
A
R
G
I
K
E
G
A
A
N
S
I
L
I
K
V
N
Q
I
G
T
L
T
E
T
F
E
A
I
E
M
A
K
E
A
G
Y
T
A
V
V
S
H
R
S
G
-
E
T
E
D
S
T
I
A
D
I
A
V
A
T
N
A
G
Q
I
K
T
G
S
L
S
R
T
D
R
I
A
K
Y
N
Q
L
L
R
I
E
D
Q
L
G
E
V
A
V
Y
K
G
L
N
S
F
-
Y
N
L
--
14
PsiBlast_PDB
88.07
60%
-72
- C1 -
3TQP
2
ENO_COXBU
A:
[3-426]
-
A
T
I
T
D
I
N
A
H
E
I
L
D
S
R
A
N
P
T
L
E
V
R
V
T
L
S
S
Q
A
----------
Y
G
C
A
A
V
P
S
G
A
----
E
R
E
A
V
E
L
R
D
N
D
L
E
R
Y
G
G
K
G
V
L
Q
A
V
E
N
V
N
G
P
I
R
D
A
L
L
--
G
--
Q
D
P
R
S
Q
E
E
I
D
R
I
M
I
E
L
D
G
T
E
N
K
A
N
L
G
A
N
A
I
L
G
V
S
L
A
V
A
Y
A
A
A
N
N
A
D
L
P
L
Y
R
Y
---
L
G
G
D
G
-----
G
---
P
-----
F
S
M
P
V
P
M
M
N
I
I
N
G
G
----
N
N
L
D
F
Q
E
F
M
I
V
P
V
G
A
P
T
---
F
A
E
---
A
L
R
Y
G
A
E
V
F
H
A
----
L
K
K
R
L
V
S
R
--
G
--
L
M
-
S
A
-
V
G
D
E
G
G
F
A
P
D
L
P
N
N
E
A
A
F
E
-
L
I
L
E
A
I
E
D
A
N
Y
V
P
G
K
D
-
I
Y
L
A
L
D
A
A
S
S
E
L
Y
--
Q
N
G
-----
R
Y
D
---
F
--------
E
N
--------
N
Q
-
L
T
--------
S
-
E
E
M
I
D
R
L
T
E
W
T
K
K
Y
P
V
I
S
I
E
D
G
L
S
E
N
D
W
A
G
W
K
L
L
T
E
R
L
E
N
K
V
Q
L
V
G
D
D
I
F
V
T
N
P
D
I
L
E
K
G
I
K
K
N
I
A
N
A
I
L
V
K
L
N
Q
I
G
T
L
T
E
T
L
A
T
V
G
L
A
K
S
N
K
Y
G
V
I
I
S
H
R
S
G
-
E
T
E
D
T
T
I
A
D
L
A
V
A
T
D
A
R
Q
I
K
T
G
S
L
C
R
S
D
R
V
A
K
Y
N
R
L
L
Q
I
E
R
E
L
N
D
Q
A
P
Y
A
G
K
E
A
F
L
F
N
---
12
PsiBlast_PDB
87.99
64%
-67
- C1 -
4ROP
6
ENO_SYNP6
A:
[9-421]
---
I
A
E
I
T
A
R
E
I
L
D
S
R
G
R
P
T
V
E
A
E
V
H
L
E
D
G
S
----------
V
G
L
A
Q
V
P
S
G
A
-
S
T
G
T
F
E
A
H
E
L
R
D
D
D
P
S
R
Y
G
G
K
G
V
Q
K
A
V
E
N
V
S
-
A
I
E
D
A
L
I
--
G
--
L
S
A
L
D
Q
E
G
L
D
K
A
M
I
A
L
D
G
T
P
N
K
K
N
L
G
A
N
A
I
L
A
V
S
L
A
T
A
H
A
A
A
T
S
L
N
L
P
L
Y
R
Y
---
L
G
G
P
L
-----
A
---
N
-----
V
-
L
P
V
P
M
M
N
V
I
N
G
G
A
H
A
D
N
N
V
D
F
Q
E
F
M
I
M
P
V
G
A
P
S
---
F
K
E
---
A
L
R
W
G
A
E
V
F
H
A
----
L
A
K
V
L
K
D
K
--
G
--
L
A
-
T
G
-
V
G
D
E
G
G
F
A
P
N
L
G
S
N
K
E
A
L
E
-
L
L
L
T
A
I
E
A
A
G
Y
K
P
G
E
Q
-
V
A
L
A
M
D
V
A
S
S
E
F
Y
--
K
N
G
-----
L
Y
T
---
C
------------------
D
G
-
V
S
H
------
E
P
-
A
G
M
I
G
I
L
A
D
L
V
S
Q
Y
P
I
V
S
I
E
D
G
L
Q
E
D
D
W
S
N
W
K
T
L
T
Q
Q
L
G
S
T
V
Q
L
V
G
D
D
L
F
V
T
N
P
D
R
L
Q
S
G
I
E
Q
G
V
G
N
A
V
L
I
K
L
N
Q
I
G
T
L
T
E
T
L
R
T
I
D
L
A
T
R
S
G
Y
R
S
V
I
S
H
R
S
G
-
E
T
E
D
T
T
I
A
D
L
A
V
A
T
R
A
G
Q
I
K
T
G
S
L
S
R
S
E
R
I
A
K
Y
N
R
L
L
R
I
E
A
A
L
G
E
N
A
L
Y
A
G
----------
42
PsiBlast_CBE
87.90
62%
-66
- C1 -
3UJ2
6
?
G:
[28-449]
---
I
E
K
V
I
G
R
E
I
I
D
S
R
G
N
P
T
V
E
A
E
V
Y
L
A
G
G
V
----------
T
G
R
G
T
A
P
S
G
----
G
E
F
E
A
L
E
L
R
D
G
D
K
G
R
F
G
G
K
G
V
T
K
A
V
Q
N
I
N
T
E
I
S
E
I
L
S
--
G
--
M
D
A
S
D
I
Y
A
V
D
R
A
M
I
D
A
D
G
T
K
D
K
S
K
F
G
A
N
A
V
L
A
V
S
I
A
C
A
K
A
A
A
A
A
L
G
V
P
L
Y
R
F
---
L
G
G
L
N
-----
A
---
N
-----
R
-
L
P
V
P
M
M
N
I
L
N
G
G
A
H
A
A
N
T
V
D
V
Q
E
F
M
I
M
P
V
G
A
E
S
---
F
R
E
---
A
L
R
Q
C
T
E
V
F
H
A
----
L
A
G
L
L
K
S
K
--
G
--
L
A
-
T
S
-
V
G
D
E
G
G
F
A
P
D
L
A
S
D
E
E
A
I
E
-
Y
I
L
E
A
V
K
L
A
G
Y
E
P
G
R
D
-
F
V
L
A
M
D
A
A
S
S
E
W
K
G
E
K
K
G
-----
E
Y
I
---
L
--------
P
K
--------
C
K
-
R
K
F
------
A
S
-
E
E
L
V
A
H
W
K
S
L
C
E
R
Y
P
I
V
S
I
E
D
G
L
D
E
E
D
W
E
G
W
Q
Y
M
T
R
E
L
G
D
K
I
Q
L
V
G
D
D
L
F
V
T
N
T
E
R
L
N
K
G
I
K
E
R
C
G
N
S
I
L
I
K
L
N
Q
I
G
T
V
S
E
T
L
E
A
I
K
M
A
H
K
A
G
Y
T
A
V
V
S
H
R
S
G
-
E
T
E
D
T
T
I
A
D
L
A
V
A
L
N
T
G
Q
I
K
T
G
A
P
S
R
S
E
R
V
A
K
Y
N
Q
L
L
R
I
E
E
E
L
G
D
S
A
V
Y
P
G
F
T
T
F
------
35
PsiBlast_CBE
87.87
65%
-67
- C1 -
3H8A
2
ENO_ECOLI
C:
[2-424]
-
S
K
I
V
K
I
I
G
R
E
I
I
D
S
R
G
N
P
T
V
E
A
E
V
H
L
E
G
G
F
----------
V
G
M
A
A
A
P
S
G
A
-
S
T
G
S
R
E
A
L
E
L
R
D
G
D
K
S
R
F
L
G
K
G
V
T
K
A
V
A
A
V
N
G
P
I
A
Q
A
L
I
--
G
--
K
D
A
K
D
Q
A
G
I
D
K
I
M
I
D
L
D
G
T
E
N
K
S
K
F
G
A
N
A
I
L
A
V
S
L
A
N
A
K
A
A
A
A
A
K
G
M
P
L
Y
E
H
---
I
A
E
L
N
-----
G
---
T
PGKY-
S
-
M
P
V
P
M
M
N
I
I
N
G
G
E
H
A
D
N
N
V
D
I
Q
E
F
M
I
Q
P
V
G
A
K
T
---
V
K
E
---
A
I
R
M
G
S
E
V
F
H
H
----
L
A
K
V
L
K
A
K
--
G
--
M
N
-
T
A
-
V
G
D
E
G
G
Y
A
P
N
L
G
S
N
A
E
A
L
A
-
V
I
A
E
A
V
K
A
A
G
Y
E
L
G
K
D
-
I
T
L
A
M
D
C
A
A
S
E
F
Y
--
K
D
G
-----
K
Y
V
---
L
--------
A
G
--------
E
G
N
K
A
F
------
T
S
-
E
E
F
T
H
F
L
E
E
L
T
K
Q
Y
P
I
V
S
I
E
D
G
L
D
E
S
D
W
D
G
F
A
Y
Q
T
K
V
L
G
D
K
I
Q
L
V
G
D
D
L
F
V
T
N
T
K
I
L
K
E
G
I
E
K
G
I
A
N
S
I
L
I
K
F
N
Q
I
G
S
L
T
E
T
L
A
A
I
K
M
A
K
D
A
G
Y
T
A
V
I
S
H
R
S
G
-
E
T
E
D
A
T
I
A
D
L
A
V
G
T
A
A
G
Q
I
K
T
G
S
M
S
R
S
D
R
V
A
K
Y
N
Q
L
I
R
I
E
E
A
L
G
E
K
A
P
Y
N
G
----------
36
PsiBlast_CBE
87.75
65%
-65
- C1 -
2FYM
2
ENO_ECOLI
F:
[1-423]
-
S
K
I
V
K
I
I
G
R
E
I
I
D
S
R
G
N
P
T
V
E
A
E
V
H
L
E
G
G
F
----------
V
G
M
A
A
A
P
S
G
A
-
S
T
G
S
R
E
A
L
E
L
R
D
G
D
K
S
R
F
L
G
K
G
V
T
K
A
V
A
A
V
N
G
P
I
A
Q
A
L
I
--
G
--
K
D
A
K
D
Q
A
G
I
D
K
I
M
I
D
L
D
G
T
E
N
K
S
K
F
G
A
N
A
I
L
A
V
S
L
A
N
A
K
A
A
A
A
A
K
G
M
P
L
Y
E
H
---
I
A
E
L
N
-----
G
---
T
PGKY-
S
-
M
P
V
P
M
M
N
I
I
N
G
G
E
H
A
D
N
N
V
D
I
Q
E
F
M
I
Q
P
V
G
A
K
T
---
V
K
E
---
A
I
R
M
G
S
E
V
F
H
H
----
L
A
K
V
L
K
A
K
--
G
--
M
N
-
T
A
-
V
G
D
E
G
G
Y
A
P
N
L
G
S
N
A
E
A
L
A
-
V
I
A
E
A
V
K
A
A
G
Y
E
L
G
K
D
-
I
T
L
A
M
D
C
A
A
S
E
F
Y
--
K
D
G
-----
K
Y
V
---
L
--------
A
G
--------
E
G
N
K
A
F
------
T
S
-
E
E
F
T
H
F
L
E
E
L
T
K
Q
Y
P
I
V
S
I
E
D
G
L
D
E
S
D
W
D
G
F
A
Y
Q
T
K
V
L
G
D
K
I
Q
L
V
G
D
D
L
F
V
T
N
T
K
I
L
K
E
G
I
E
K
G
I
A
N
S
I
L
I
K
F
N
Q
I
G
S
L
T
E
T
L
A
A
I
K
M
A
K
D
A
G
Y
T
A
V
I
S
H
R
S
G
-
E
T
E
D
A
T
I
A
D
L
A
V
G
T
A
A
G
Q
I
K
T
G
S
M
S
R
S
D
R
V
A
K
Y
N
Q
L
I
R
I
E
E
A
L
G
E
K
A
P
Y
N
G
----------
43
PsiBlast_CBE
87.37
62%
-67
- C1 -
3UJ2
1
?
F:
[28-449]
---
I
E
K
V
I
G
R
E
I
I
D
S
R
G
N
P
T
V
E
A
E
V
Y
L
A
G
G
V
----------
T
G
R
G
T
A
P
S
G
----
G
E
F
E
A
L
E
L
R
D
G
D
K
G
R
F
G
G
K
G
V
T
K
A
V
Q
N
I
N
T
E
I
S
E
I
L
S
--
G
--
M
D
A
S
D
I
Y
A
V
D
R
A
M
I
D
A
D
G
T
K
D
K
S
K
F
G
A
N
A
V
L
A
V
S
I
A
C
A
K
A
A
A
A
A
L
G
V
P
L
Y
R
F
---
L
G
G
L
N
-----
A
---
N
-----
R
-
L
P
V
P
M
M
N
I
L
N
G
G
A
H
A
A
N
T
V
D
V
Q
E
F
M
I
M
P
V
G
A
E
S
---
F
R
E
---
A
L
R
Q
C
T
E
V
F
H
A
----
L
A
G
L
L
K
S
K
--
G
--
L
A
-
T
S
-
V
G
D
E
G
G
F
A
P
D
L
A
S
D
E
E
A
I
E
-
Y
I
L
E
A
V
K
L
A
G
Y
E
P
G
R
D
-
F
V
L
A
M
D
A
A
S
S
E
W
K
G
E
K
K
G
-----
E
Y
I
---
L
--------
P
K
--------
C
K
-
R
K
F
------
A
S
-
E
E
L
V
A
H
W
K
S
L
C
E
R
Y
P
I
V
S
I
E
D
G
L
D
E
E
D
W
E
G
W
Q
Y
M
T
R
E
L
G
D
K
I
Q
L
V
G
D
D
L
F
V
T
N
T
E
R
L
N
K
G
I
K
E
R
C
G
N
S
I
L
I
K
L
N
Q
I
G
T
V
S
E
T
L
E
A
I
K
M
A
H
K
A
G
Y
T
A
V
V
S
H
R
S
G
-
E
T
E
D
T
T
I
A
D
L
A
V
A
L
N
T
G
Q
I
K
T
G
A
P
S
R
S
E
R
V
A
K
Y
N
Q
L
L
R
I
E
E
E
L
G
D
S
A
V
Y
P
G
F
T
T
F
------
13
PsiBlast_PDB
87.32
62%
-67
- C1 -
3UJ2
5
?
A:
[28-449]
---
I
E
K
V
I
G
R
E
I
I
D
S
R
G
N
P
T
V
E
A
E
V
Y
L
A
G
G
V
----------
T
G
R
G
T
A
P
S
G
----
G
E
F
E
A
L
E
L
R
D
G
D
K
G
R
F
G
G
K
G
V
T
K
A
V
Q
N
I
N
T
E
I
S
E
I
L
S
--
G
--
M
D
A
S
D
I
Y
A
V
D
R
A
M
I
D
A
D
G
T
K
D
K
S
K
F
G
A
N
A
V
L
A
V
S
I
A
C
A
K
A
A
A
A
A
L
G
V
P
L
Y
R
F
---
L
G
G
L
N
-----
A
---
N
-----
R
-
L
P
V
P
M
M
N
I
L
N
G
G
A
H
A
A
N
T
V
D
V
Q
E
F
M
I
M
P
V
G
A
E
S
---
F
R
E
---
A
L
R
Q
C
T
E
V
F
H
A
----
L
A
G
L
L
K
S
K
--
G
--
L
A
-
T
S
-
V
G
D
E
G
G
F
A
P
D
L
A
S
D
E
E
A
I
E
-
Y
I
L
E
A
V
K
L
A
G
Y
E
P
G
R
D
-
F
V
L
A
M
D
A
A
S
S
E
W
K
G
E
K
K
G
-----
E
Y
I
---
L
--------
P
K
--------
C
K
-
R
K
F
------
A
S
-
E
E
L
V
A
H
W
K
S
L
C
E
R
Y
P
I
V
S
I
E
D
G
L
D
E
E
D
W
E
G
W
Q
Y
M
T
R
E
L
G
D
K
I
Q
L
V
G
D
D
L
F
V
T
N
T
E
R
L
N
K
G
I
K
E
R
C
G
N
S
I
L
I
K
L
N
Q
I
G
T
V
S
E
T
L
E
A
I
K
M
A
H
K
A
G
Y
T
A
V
V
S
H
R
S
G
-
E
T
E
D
T
T
I
A
D
L
A
V
A
L
N
T
G
Q
I
K
T
G
A
P
S
R
S
E
R
V
A
K
Y
N
Q
L
L
R
I
E
E
E
L
G
D
S
A
V
Y
P
G
F
T
T
F
------
44
PsiBlast_CBE
87.30
62%
-67
- C1 -
3UJ2
3
?
E:
[28-449]
---
I
E
K
V
I
G
R
E
I
I
D
S
R
G
N
P
T
V
E
A
E
V
Y
L
A
G
G
V
----------
T
G
R
G
T
A
P
S
G
----
G
E
F
E
A
L
E
L
R
D
G
D
K
G
R
F
G
G
K
G
V
T
K
A
V
Q
N
I
N
T
E
I
S
E
I
L
S
--
G
--
M
D
A
S
D
I
Y
A
V
D
R
A
M
I
D
A
D
G
T
K
D
K
S
K
F
G
A
N
A
V
L
A
V
S
I
A
C
A
K
A
A
A
A
A
L
G
V
P
L
Y
R
F
---
L
G
G
L
N
-----
A
---
N
-----
R
-
L
P
V
P
M
M
N
I
L
N
G
G
A
H
A
A
N
T
V
D
V
Q
E
F
M
I
M
P
V
G
A
E
S
---
F
R
E
---
A
L
R
Q
C
T
E
V
F
H
A
----
L
A
G
L
L
K
S
K
--
G
--
L
A
-
T
S
-
V
G
D
E
G
G
F
A
P
D
L
A
S
D
E
E
A
I
E
-
Y
I
L
E
A
V
K
L
A
G
Y
E
P
G
R
D
-
F
V
L
A
M
D
A
A
S
S
E
W
K
G
E
K
K
G
-----
E
Y
I
---
L
--------
P
K
--------
C
K
-
R
K
F
------
A
S
-
E
E
L
V
A
H
W
K
S
L
C
E
R
Y
P
I
V
S
I
E
D
G
L
D
E
E
D
W
E
G
W
Q
Y
M
T
R
E
L
G
D
K
I
Q
L
V
G
D
D
L
F
V
T
N
T
E
R
L
N
K
G
I
K
E
R
C
G
N
S
I
L
I
K
L
N
Q
I
G
T
V
S
E
T
L
E
A
I
K
M
A
H
K
A
G
Y
T
A
V
V
S
H
R
S
G
-
E
T
E
D
T
T
I
A
D
L
A
V
A
L
N
T
G
Q
I
K
T
G
A
P
S
R
S
E
R
V
A
K
Y
N
Q
L
L
R
I
E
E
E
L
G
D
S
A
V
Y
P
G
F
T
T
F
------
7
PsiBlast_PDB
86.50
63%
-70
- C1 -
4Z17
3
ENO_CHLAA
A:
[3-424]
-
T
L
I
E
A
I
V
A
R
E
V
L
D
S
R
G
N
P
T
I
E
V
D
V
R
L
E
S
G
D
----------
V
G
R
A
I
V
P
S
G
A
-
S
T
G
A
H
E
A
L
E
L
R
D
G
D
K
S
R
Y
N
G
K
G
V
L
K
A
V
Q
A
V
N
E
D
I
A
E
A
L
I
--
G
--
F
D
A
A
D
Q
I
A
L
D
Q
E
L
I
A
L
D
G
T
P
N
K
S
K
L
G
A
N
A
I
L
G
V
S
L
A
A
A
K
A
A
A
A
A
F
G
L
P
L
Y
R
Y
---
L
G
G
V
Y
-----
A
---
H
-----
V
-
L
P
V
P
M
M
N
I
M
N
G
G
Q
H
--
N
S
T
D
F
Q
E
F
M
I
M
P
V
G
A
E
S
---
F
R
E
---
G
L
R
W
G
A
E
I
Y
H
M
----
L
K
K
V
I
H
D
R
--
G
--
F
S
-
T
T
-
V
G
D
E
G
G
F
A
P
S
L
P
T
N
D
A
P
L
Q
-
L
I
M
E
A
I
E
K
A
G
Y
R
P
G
E
Q
-
I
V
I
A
L
D
P
A
T
T
E
I
F
--
E
D
G
-----
K
Y
H
---
L
--------
K
R
--------
E
G
-
R
S
L
------
S
S
-
A
E
M
V
D
Y
W
V
D
L
V
N
R
Y
P
I
I
S
L
E
D
G
L
A
E
D
D
W
E
G
W
A
L
L
R
A
K
L
G
D
R
V
Q
L
V
G
D
D
F
L
V
T
N
V
Q
R
L
Q
R
A
I
E
A
K
A
A
N
S
I
L
I
K
L
N
Q
I
G
S
L
T
E
T
L
S
A
I
Q
L
A
Q
R
S
G
W
T
A
V
V
S
H
R
S
G
-
E
S
E
D
V
T
I
A
D
L
V
V
A
T
N
A
G
Q
I
K
T
G
A
P
A
R
T
D
R
I
A
K
Y
N
Q
L
L
R
I
E
E
E
L
G
S
A
A
R
Y
A
G
R
S
A
F
------
32
PsiBlast_CBE
84.46
63%
-71
- C1 -
4Z17
3
ENO_CHLAA
B:
[3-424]
-
T
L
I
E
A
I
V
A
R
E
V
L
D
S
R
G
N
P
T
I
E
V
D
V
R
L
E
S
G
D
----------
V
G
R
A
I
V
P
S
G
A
-
S
T
G
A
H
E
A
L
E
L
R
D
G
D
K
S
R
Y
N
G
K
G
V
L
K
A
V
Q
A
V
N
E
D
I
A
E
A
L
I
--
G
--
F
D
A
A
D
Q
I
A
L
D
Q
E
L
I
A
L
D
G
T
P
N
K
S
K
L
G
A
N
A
I
L
G
V
S
L
A
A
A
K
A
A
A
A
A
F
G
L
P
L
Y
R
Y
---
L
G
G
V
Y
-----
A
---
H
-----
V
-
L
P
V
P
M
M
N
I
M
N
G
G
Q
H
A
-----
F
Q
E
F
M
I
M
P
V
G
A
E
S
---
F
R
E
---
G
L
R
W
G
A
E
I
Y
H
M
----
L
K
K
V
I
H
D
R
--
G
--
F
S
-
T
T
-
V
G
D
E
G
G
F
A
P
S
L
P
T
N
D
A
P
L
Q
-
L
I
M
E
A
I
E
K
A
G
Y
R
P
G
E
Q
-
I
V
I
A
L
D
P
A
T
T
E
I
F
--
E
D
G
-----
K
Y
H
---
L
--------
K
R
--------
E
G
-
R
S
L
------
S
S
-
A
E
M
V
D
Y
W
V
D
L
V
N
R
Y
P
I
I
S
L
E
D
G
L
A
E
D
D
W
E
G
W
A
L
L
R
A
K
L
G
D
R
V
Q
L
V
G
D
D
F
L
V
T
N
V
Q
R
L
Q
R
A
I
E
A
K
A
A
N
S
I
L
I
K
L
N
Q
I
G
S
L
T
E
T
L
S
A
I
Q
L
A
Q
R
S
G
W
T
A
V
V
S
H
R
S
G
-
E
S
E
D
V
T
I
A
D
L
V
V
A
T
N
A
G
Q
I
K
T
G
A
P
A
R
T
D
R
I
A
K
Y
N
Q
L
L
R
I
E
E
E
L
G
S
A
A
R
Y
A
G
R
S
A
F
------
91
PsiBlast_CBE
82.71
50%
-63
- C1 -
5ENL
2
ENO1_YEAST
A:
[2-432]
---
V
S
K
V
Y
A
R
S
V
Y
D
S
R
G
N
P
T
V
E
V
E
L
T
T
E
K
G
V
----------
F
-
R
S
I
V
P
S
G
A
-
S
T
G
V
H
E
A
L
E
M
R
D
G
D
K
S
K
W
M
G
K
G
V
L
H
A
V
K
N
V
N
D
V
I
A
P
A
F
V
K
A
N
--
I
D
V
S
D
Q
K
A
V
D
D
F
L
I
S
L
D
G
T
A
N
K
S
K
L
G
A
N
A
I
L
G
V
S
L
A
A
S
R
A
A
A
A
E
K
N
V
P
L
Y
K
H
---
L
A
D
L
S
-----
K
---
S
KTSP
Y
V
-
L
P
V
P
F
L
N
V
L
N
G
G
S
H
A
G
G
A
L
A
L
Q
E
F
M
I
A
P
T
G
A
K
T
---
F
A
E
---
A
L
R
I
G
S
E
V
Y
H
N
----
L
K
S
L
T
K
K
R
Y-
G
--
A
S
-
A
G
N
V
G
D
E
G
G
V
A
P
N
I
Q
T
A
E
E
A
L
D
-
L
I
V
D
A
I
K
A
A
G
H
D
--
G
K
-
V
K
I
G
L
D
C
A
S
S
E
F
F
--
K
D
G
-----
K
Y
D
---
L
--------
D
F
--------
K
N
-
P
N
S
DKSK
W
L
T
G
-
P
Q
L
A
D
L
Y
H
S
L
M
K
R
Y
P
I
V
S
I
E
D
P
F
A
E
D
D
W
E
A
W
S
H
F
F
K
T
A
G
--
I
Q
I
V
A
D
D
L
T
V
T
N
P
K
R
I
A
T
A
I
E
K
K
A
A
D
A
L
L
L
K
V
N
Q
I
G
T
L
S
E
S
I
K
A
A
Q
D
S
F
A
A
G
W
G
V
M
V
S
H
R
S
G
-
E
T
E
D
T
F
I
A
D
L
V
V
G
L
R
T
G
Q
I
K
T
G
A
P
A
R
S
E
R
L
A
K
L
N
Q
L
L
R
I
E
E
E
L
G
D
N
A
V
F
A
G
E
N
F
H
-
H
----
95
PsiBlast_CBE
82.68
50%
-61
- C1 -
1ELS
3
ENO1_YEAST
A:
[2-432]
---
V
S
K
V
Y
A
R
S
V
Y
D
S
R
G
N
P
T
V
E
V
E
L
T
T
E
K
G
V
----------
F
-
R
S
I
V
P
S
G
A
-
S
T
G
V
H
E
A
L
E
M
R
D
G
D
K
S
K
W
M
G
K
G
V
L
H
A
V
K
N
V
N
D
V
I
A
P
A
F
V
K
A
N
--
I
D
V
S
D
Q
K
A
V
D
D
F
L
I
S
L
D
G
T
A
N
K
S
K
L
G
A
N
A
I
L
G
V
S
L
A
A
S
R
A
A
A
A
E
K
N
V
P
L
Y
K
H
---
L
A
D
L
S
-----
K
---
S
KTSP
Y
V
-
L
P
V
P
F
L
N
V
L
N
G
G
S
H
A
G
G
A
L
A
L
Q
E
F
M
I
A
P
T
G
A
K
T
---
F
A
E
---
A
L
R
I
G
S
E
V
Y
H
N
----
L
K
S
L
T
K
K
R
Y-
G
--
A
S
-
A
G
N
V
G
D
E
G
G
V
A
P
N
I
Q
T
A
E
E
A
L
D
-
L
I
V
D
A
I
K
A
A
G
H
D
--
G
K
-
V
K
I
G
L
D
C
A
S
S
E
F
F
--
K
D
G
-----
K
Y
D
---
L
--------
D
F
--------
K
N
-
P
N
S
DKSK
W
L
T
G
-
P
Q
L
A
D
L
Y
H
S
L
M
K
R
Y
P
I
V
S
I
E
D
P
F
A
E
D
D
W
E
A
W
S
H
F
F
K
T
A
G
--
I
Q
I
V
A
D
D
L
T
V
T
N
P
K
R
I
A
T
A
I
E
K
K
A
A
D
A
L
L
L
K
V
N
Q
I
G
T
L
S
E
S
I
K
A
A
Q
D
S
F
A
A
G
W
G
V
M
V
S
H
R
S
G
-
E
T
E
D
T
F
I
A
D
L
V
V
G
L
R
T
G
Q
I
K
T
G
A
P
A
R
S
E
R
L
A
K
L
N
Q
L
L
R
I
E
E
E
L
G
D
N
A
V
F
A
G
E
N
F
H
-
H
----
17
PsiBlast_PDB
81.78
53%
-65
- C1 -
3QTP
6
ENO1_ENTHI
A:
[8-429]
---
I
Q
K
V
H
A
R
E
I
L
D
S
R
G
N
P
T
I
E
V
E
I
T
T
G
K
G
M
----------
F
-
R
S
C
V
P
S
G
A
-
S
T
G
V
H
E
A
V
E
L
R
D
G
D
K
K
R
Y
G
G
K
G
V
L
K
A
V
E
N
V
N
T
I
I
G
P
A
L
L
--
G
--
K
N
V
L
N
Q
A
E
L
D
E
M
M
I
K
L
D
G
T
N
N
K
G
K
L
G
A
N
A
I
L
G
C
S
M
S
I
C
R
A
A
A
A
E
K
G
L
P
L
Y
K
Y
---
L
A
E
L
T
-----
G
---
H
K
E
M
--
T
-
M
P
V
P
C
F
N
V
I
N
G
G
A
H
A
G
N
A
L
A
M
Q
E
F
M
I
C
P
T
G
A
T
N
---
F
H
E
---
A
L
R
M
A
A
E
T
Y
Q
C
----
L
K
V
V
I
K
A
K
Y-
G
--
Q
D
A
T
N
-
V
G
D
E
G
G
F
A
P
N
V
S
G
A
R
E
A
L
D
-
L
L
V
E
A
I
A
K
A
G
Y
T
--
G
K
-
I
E
I
A
M
D
C
A
A
S
E
F
Y
N
E
E
T
K
-----
K
Y
D
---
L
GKKIPADK
K
D
--------
P
S
-
L
V
K
------
D
V
-
D
G
L
I
A
E
Y
V
D
Y
G
K
H
Y
P
I
A
S
I
E
D
P
F
A
E
D
D
W
A
A
W
N
K
F
T
V
E
H
G
N
-
F
Q
I
V
G
D
D
L
L
V
T
N
P
A
R
V
Q
M
A
M
D
K
N
A
C
N
S
V
L
I
K
V
N
Q
I
G
T
L
T
E
T
F
K
T
I
K
M
A
Q
E
K
G
W
G
V
M
A
S
H
R
S
G
-
E
T
E
D
T
F
I
A
D
L
V
V
G
L
N
C
K
Q
I
K
T
G
A
P
C
R
S
E
R
L
C
K
Y
N
Q
L
M
R
I
E
E
E
L
G
N
I
---------------
98
PsiBlast_CBE
81.16
50%
-65
- C1 -
2AL1
6
ENO1_YEAST
B:
[2-432]
---
V
S
K
V
Y
A
R
S
V
Y
D
S
R
G
N
P
T
V
E
V
E
L
T
T
E
K
G
V
----------
F
-
R
S
I
V
P
S
G
A
-
S
T
G
V
H
E
A
L
E
M
R
D
G
D
K
S
K
W
M
G
K
G
V
L
H
A
V
K
N
V
N
D
V
I
A
P
A
F
V
K
A
N
--
I
D
V
K
D
Q
K
A
V
D
D
F
L
I
S
L
D
G
T
A
N
K
S
K
L
G
A
N
A
I
L
G
V
S
L
A
A
S
R
A
A
A
A
E
K
N
V
P
L
Y
K
H
---
L
A
D
L
S
-----
K
---
S
KTSP
Y
V
-
L
P
V
P
F
L
N
V
L
N
G
G
-----
A
L
A
L
Q
E
F
M
I
A
P
T
G
A
K
T
---
F
A
E
---
A
L
R
I
G
S
E
V
Y
H
N
----
L
K
S
L
T
K
K
R
Y-
G
--
A
S
-
A
G
N
V
G
D
E
G
G
V
A
P
N
I
Q
T
A
E
E
A
L
D
-
L
I
V
D
A
I
K
A
A
G
H
D
--
G
K
-
V
K
I
G
L
D
C
A
S
S
E
F
F
--
K
D
G
-----
K
Y
D
---
L
--------
D
F
--------
K
N
-
P
N
S
DKSKWL
T
G
-
P
Q
L
A
D
L
Y
H
S
L
M
K
R
Y
P
I
V
S
I
E
D
P
F
A
E
D
D
W
E
A
W
S
H
F
F
K
T
A
G
--
I
Q
I
V
A
D
D
L
T
V
T
N
P
K
R
I
A
T
A
I
E
K
K
A
A
D
A
L
L
L
K
V
N
Q
I
G
T
L
S
E
S
I
K
A
A
Q
D
S
F
A
A
G
W
G
V
M
V
S
H
R
S
G
-
E
T
E
D
T
F
I
A
D
L
V
V
G
L
R
T
G
Q
I
K
T
G
A
P
A
R
S
E
R
L
A
K
L
N
Q
L
L
R
I
E
E
E
L
G
D
N
A
V
F
A
G
E
N
F
H
-
H
----
90
PsiBlast_CBE
81.12
50%
-61
- C1 -
6ENL
2
ENO1_YEAST
A:
[2-432]
---
V
S
K
V
Y
A
R
S
V
Y
D
S
R
G
N
P
T
V
E
V
E
L
T
T
E
K
G
V
----------
F
-
R
S
I
V
P
S
G
A
-
S
T
G
V
H
E
A
L
E
M
R
D
G
D
K
S
K
W
M
G
K
G
V
L
H
A
V
K
N
V
N
D
V
I
A
P
A
F
V
K
A
N
--
I
D
V
S
D
Q
K
A
V
D
D
F
L
I
S
L
D
G
T
A
N
K
S
K
L
G
A
N
A
I
L
G
V
S
L
A
A
S
R
A
A
A
A
E
K
N
V
P
L
Y
K
H
---
L
A
D
L
S
-----
K
---
S
KTSP
Y
V
-
L
P
V
P
F
L
N
V
L
N
G
G
S
H
A
G
G
A
L
A
L
Q
E
F
M
I
A
P
T
G
A
K
T
---
F
A
E
---
A
L
R
I
G
S
E
V
Y
H
N
----
L
K
S
L
T
K
K
R
Y-
G
--
A
S
-
A
G
N
V
G
D
E
G
G
V
A
P
N
I
Q
T
A
E
E
A
L
D
-
L
I
V
D
A
I
K
A
A
G
H
D
--
G
K
-
V
K
I
G
L
D
C
A
S
S
E
F
F
--
K
D
G
-----
K
Y
D
---
L
--------
D
F
--------
K
N
-
P
N
S
DKSKWL
T
G
-
P
Q
L
A
D
L
Y
H
S
L
M
K
R
Y
P
I
V
S
I
E
D
P
F
A
E
D
D
W
E
A
W
S
H
F
F
K
T
A
G
--
I
Q
I
V
A
D
D
L
T
V
T
N
P
K
R
I
A
T
A
I
E
K
K
A
A
D
A
L
L
L
K
V
N
Q
I
G
T
L
S
E
S
I
K
A
A
Q
D
S
F
A
A
G
W
G
V
M
V
S
H
R
S
G
-
E
T
E
D
T
F
I
A
D
L
V
V
G
L
R
T
G
Q
I
K
T
G
A
P
A
R
S
E
R
L
A
K
L
N
Q
L
L
R
I
E
E
E
L
G
D
N
A
V
F
A
G
E
N
F
H
-
H
----
97
PsiBlast_CBE
80.89
50%
-59
- C1 -
2ONE
3
ENO1_YEAST
A:
[2-432]
---
V
S
K
V
Y
A
R
S
V
Y
D
S
R
G
N
P
T
V
E
V
E
L
T
T
E
K
G
V
----------
F
-
R
S
I
V
P
S
G
A
-
S
T
G
V
H
E
A
L
E
M
R
D
G
D
K
S
K
W
M
G
K
G
V
L
H
A
V
K
N
V
N
D
V
I
A
P
A
F
V
K
A
N
--
I
D
V
K
D
Q
K
A
V
D
D
F
L
I
S
L
D
G
T
A
N
K
S
K
L
G
A
N
A
I
L
G
V
S
L
A
A
S
R
A
A
A
A
E
K
N
V
P
L
Y
K
H
---
L
A
D
L
S
-----
K
---
S
KTSP
Y
V
-
L
P
V
P
F
L
N
V
L
N
G
G
S
H
A
G
G
A
L
A
L
Q
E
F
M
I
A
P
T
G
A
K
T
---
F
A
E
---
A
L
R
I
G
S
E
V
Y
H
N
----
L
K
S
L
T
K
K
R
Y-
G
--
A
S
-
A
G
N
V
G
D
E
G
G
V
A
P
N
I
Q
T
A
E
E
A
L
D
-
L
I
V
D
A
I
K
A
A
G
H
D
--
G
K
-
V
K
I
G
L
D
C
A
S
S
E
F
F
--
K
D
G
-----
K
Y
D
---
L
--------
D
F
--------
K
N
-
P
N
S
DKSKWL
T
G
-
P
Q
L
A
D
L
Y
H
S
L
M
K
R
Y
P
I
V
S
I
E
D
P
F
A
E
D
D
W
E
A
W
S
H
F
F
K
T
A
G
--
I
Q
I
V
A
D
D
L
T
V
T
N
P
K
R
I
A
T
A
I
E
K
K
A
A
D
A
L
L
L
K
V
N
Q
I
G
T
L
S
E
S
I
K
A
A
Q
D
S
F
A
A
G
W
G
V
M
V
S
H
R
S
G
-
E
T
E
D
T
F
I
A
D
L
V
V
G
L
R
T
G
Q
I
K
T
G
A
P
A
R
S
E
R
L
A
K
L
N
Q
L
L
R
I
E
E
E
L
G
D
N
A
V
F
A
G
E
N
F
H
-
H
----
51
PsiBlast_CBE
80.79
53%
-65
- C1 -
3QTP
6
ENO1_ENTHI
B:
[8-429]
---
I
Q
K
V
H
A
R
E
I
L
D
S
R
G
N
P
T
I
E
V
E
I
T
T
G
K
G
M
----------
F
-
R
S
C
V
P
S
G
A
-
S
T
G
V
H
E
A
V
E
L
R
D
G
D
K
K
R
Y
G
G
K
G
V
L
K
A
V
E
N
V
N
T
I
I
G
P
A
L
L
--
G
--
K
N
V
L
N
Q
A
E
L
D
E
M
M
I
K
L
D
G
T
N
N
K
G
K
L
G
A
N
A
I
L
G
C
S
M
S
I
C
R
A
A
A
A
E
K
G
L
P
L
Y
K
Y
---
L
A
E
L
T
-----
G
---
H
K
E
M
--
T
-
M
P
V
P
C
F
N
V
I
N
G
G
A
H
A
G
N
A
L
A
M
Q
E
F
M
I
C
P
T
G
A
T
N
---
F
H
E
---
A
L
R
M
A
A
E
T
Y
Q
C
----
L
K
V
V
I
K
A
K
Y-
G
--
Q
D
A
T
N
-
V
G
D
E
G
G
F
A
P
N
V
S
G
A
R
E
A
L
D
-
L
L
V
E
A
I
A
K
A
G
Y
T
--
G
K
-
I
E
I
A
M
D
C
A
A
S
E
F
Y
N
E
E
T
K
-----
K
Y
D
---
L
GKKIPADK
K
D
--------
P
S
-
L
V
K
------
D
V
-
D
G
L
I
A
E
Y
V
D
Y
G
K
H
Y
P
I
A
S
I
E
D
P
F
A
E
D
D
W
A
A
W
N
K
F
T
V
E
H
G
N
-
F
Q
I
V
G
D
D
L
L
V
T
N
P
A
R
V
Q
M
A
M
D
K
N
A
C
N
S
V
L
I
K
V
N
Q
I
G
T
L
T
E
T
F
K
T
I
K
M
A
Q
E
K
G
W
G
V
M
A
S
H
R
S
G
-
E
T
E
D
T
F
I
A
D
L
V
V
G
L
N
C
K
Q
I
K
T
G
A
P
C
R
S
E
R
L
C
K
Y
N
Q
L
M
R
I
E
E
E
L
G
N
I
---------------
99
PsiBlast_CBE
80.73
50%
-59
- C1 -
2AL1
3
ENO1_YEAST
A:
[2-432]
---
V
S
K
V
Y
A
R
S
V
Y
D
S
R
G
N
P
T
V
E
V
E
L
T
T
E
K
G
V
----------
F
-
R
S
I
V
P
S
G
A
-
S
T
G
V
H
E
A
L
E
M
R
D
G
D
K
S
K
W
M
G
K
G
V
L
H
A
V
K
N
V
N
D
V
I
A
P
A
F
V
K
A
N
--
I
D
V
K
D
Q
K
A
V
D
D
F
L
I
S
L
D
G
T
A
N
K
S
K
L
G
A
N
A
I
L
G
V
S
L
A
A
S
R
A
A
A
A
E
K
N
V
P
L
Y
K
H
---
L
A
D
L
S
-----
K
---
S
KTSP
Y
V
-
L
P
V
P
F
L
N
V
L
N
G
G
S
H
A
G
G
A
L
A
L
Q
E
F
M
I
A
P
T
G
A
K
T
---
F
A
E
---
A
L
R
I
G
S
E
V
Y
H
N
----
L
K
S
L
T
K
K
R
Y-
G
--
A
S
-
A
G
N
V
G
D
E
G
G
V
A
P
N
I
Q
T
A
E
E
A
L
D
-
L
I
V
D
A
I
K
A
A
G
H
D
--
G
K
-
V
K
I
G
L
D
C
A
S
S
E
F
F
--
K
D
G
-----
K
Y
D
---
L
--------
D
F
--------
K
N
-
P
N
S
DKSK
W
L
T
G
-
P
Q
L
A
D
L
Y
H
S
L
M
K
R
Y
P
I
V
S
I
E
D
P
F
A
E
D
D
W
E
A
W
S
H
F
F
K
T
A
G
--
I
Q
I
V
A
D
D
L
T
V
T
N
P
K
R
I
A
T
A
I
E
K
K
A
A
D
A
L
L
L
K
V
N
Q
I
G
T
L
S
E
S
I
K
A
A
Q
D
S
F
A
A
G
W
G
V
M
V
S
H
R
S
G
-
E
T
E
D
T
F
I
A
D
L
V
V
G
L
R
T
G
Q
I
K
T
G
A
P
A
R
S
E
R
L
A
K
L
N
Q
L
L
R
I
E
E
E
L
G
D
N
A
V
F
A
G
E
N
F
H
-
H
----
100
PsiBlast_CBE
80.45
50%
-59
- C1 -
1ONE
3
ENO1_YEAST
B:
[2-432]
---
V
S
K
V
Y
A
R
S
V
Y
D
S
R
G
N
P
T
V
E
V
E
L
T
T
E
K
G
V
----------
F
-
R
S
I
V
P
S
G
A
-
S
T
G
V
H
E
A
L
E
M
R
D
G
D
K
S
K
W
M
G
K
G
V
L
H
A
V
K
N
V
N
D
V
I
A
P
A
F
V
KA
N
--
I
D
V
K
D
Q
K
A
V
D
D
F
L
I
S
L
D
G
T
A
N
K
S
K
L
G
A
N
A
I
L
G
V
S
L
A
A
S
R
A
A
A
A
E
K
N
V
P
L
Y
K
H
---
L
A
D
L
S
-----
K
---
S
KTSPY
V
-
L
P
V
P
F
L
N
V
L
N
G
G
S
H
A
G
G
A
L
A
L
Q
E
F
M
I
A
P
T
G
A
K
T
---
F
A
E
---
A
L
R
I
G
S
E
V
Y
H
N
----
L
K
S
L
T
K
K
R
Y-
G
--
A
S
-
A
G
N
V
G
D
E
G
G
V
A
P
N
I
Q
T
A
E
E
A
L
D
-
L
I
V
D
A
I
K
A
A
G
H
D
--
G
K
-
V
K
I
G
L
D
C
A
S
S
E
F
F
--
K
D
G
-----
K
Y
D
---
L
--------
D
F
--------
K
N
-
P
N
S
DKSKWL
T
G
-
P
Q
L
A
D
L
Y
H
S
L
M
K
R
Y
P
I
V
S
I
E
D
P
F
A
E
D
D
W
E
A
W
S
H
F
F
K
T
A
G
--
I
Q
I
V
A
D
D
L
T
V
T
N
P
K
R
I
A
T
A
I
E
K
K
A
A
D
A
L
L
L
K
V
N
Q
I
G
T
L
S
E
S
I
K
A
A
Q
D
S
F
A
A
G
W
G
V
M
V
S
H
R
S
G
-
E
T
E
D
T
F
I
A
D
L
V
V
G
L
R
T
G
Q
I
K
T
G
A
P
A
R
S
E
R
L
A
K
L
N
Q
L
L
R
I
E
E
E
L
G
D
N
A
V
F
A
G
E
N
F
H
-
H
----
57
PsiBlast_CBE
80.13
51%
-63
- C1 -
3UJS
4
ENOG_HUMAN
A:
[2-426]
---
I
E
K
I
W
A
R
E
I
L
D
S
R
G
N
P
T
V
E
V
D
L
Y
T
A
K
G
L
----------
F
-
R
A
A
V
P
S
G
A
-
S
T
G
I
Y
E
A
L
E
L
R
D
G
D
K
Q
R
Y
L
G
K
G
V
L
K
A
V
D
H
I
N
S
T
I
A
P
A
L
I
S
S
G
--
L
S
V
V
E
Q
E
K
L
D
N
L
M
L
E
L
D
G
T
E
N
K
S
K
F
G
A
N
A
I
L
G
V
S
L
A
V
C
K
A
G
A
A
E
R
E
L
P
L
Y
R
H
---
I
A
Q
L
A
-----
G
---
N
S
D
L
--
I
-
L
P
V
P
A
F
N
V
I
N
G
G
S
H
A
G
N
K
L
A
M
Q
E
F
M
I
L
P
V
G
A
E
S
---
F
R
D
---
A
M
R
L
G
A
E
V
Y
H
T
----
L
K
G
V
I
K
D
K
Y-
G
--
K
D
A
T
N
-
V
G
D
E
G
G
F
A
P
N
I
L
E
N
S
E
A
L
E
-
L
V
K
E
A
I
D
K
A
G
Y
T
--
E
K
-
I
V
I
G
M
D
V
A
A
S
E
F
Y
--
R
D
G
-----
K
Y
D
---
L
--------
D
F
--------
K
S
-
P
T
D
PSRYI-
T
G
-
D
Q
L
G
A
L
Y
Q
D
F
V
R
D
Y
P
V
V
S
I
E
D
P
F
D
Q
D
D
W
A
A
W
S
K
F
T
A
N
V
G
--
I
Q
I
V
G
D
D
L
T
V
T
N
P
K
R
I
E
R
A
V
E
E
K
A
C
N
C
L
L
L
K
V
N
Q
I
G
S
V
T
E
A
I
Q
A
C
K
L
A
Q
E
N
G
W
G
V
M
V
S
H
R
S
G
-
E
T
E
D
T
F
I
A
D
L
V
V
G
L
C
T
G
Q
I
K
T
G
A
P
C
R
S
E
R
L
A
K
Y
N
Q
L
M
R
I
E
E
E
L
G
D
E
A
R
F
A
G
H
N
--------
54
PsiBlast_CBE
80.07
51%
-63
- C1 -
3UCD
3
ENOG_HUMAN
B:
[2-426]
---
I
Q
K
I
W
A
R
E
I
L
D
S
R
G
N
P
T
V
E
V
D
L
Y
T
A
K
G
L
----------
F
-
R
A
A
V
P
S
G
A
-
S
T
G
I
Y
E
A
L
E
L
R
D
G
D
K
Q
R
Y
L
G
K
G
V
L
K
A
V
D
H
I
N
S
T
I
A
P
A
L
I
SS
G
--
L
S
V
V
E
Q
E
K
L
D
N
L
M
L
E
L
D
G
T
E
N
K
S
K
F
G
A
N
A
I
L
G
V
S
L
A
V
C
K
A
G
A
A
E
R
E
L
P
L
Y
R
H
---
I
A
Q
L
A
-----
G
---
N
SDL--
I
-
L
P
V
P
A
F
N
V
I
N
G
G
S
H
A
G
N
K
L
A
M
Q
E
F
M
I
L
P
V
G
A
E
S
---
F
R
D
---
A
M
R
L
G
A
E
V
Y
H
T
----
L
K
G
V
I
K
D
K
Y-
G
--
K
D
A
T
N
-
V
G
D
E
G
G
F
A
P
N
I
L
E
N
S
E
A
L
E
-
L
V
K
E
A
I
D
K
A
G
Y
T
--
E
K
-
I
V
I
G
M
D
V
A
A
S
E
F
Y
--
R
D
G
-----
K
Y
D
---
L
--------
D
F
--------
K
S
-
P
T
D
PSRYI-
T
G
-
D
Q
L
G
A
L
Y
Q
D
F
V
R
D
Y
P
V
V
S
I
E
D
P
F
D
Q
D
D
W
A
A
W
S
K
F
T
A
N
V
G
--
I
Q
I
V
G
D
D
L
T
V
T
N
P
K
R
I
E
R
A
V
E
E
K
A
C
N
C
L
L
L
K
V
N
Q
I
G
S
V
T
E
A
I
Q
A
C
K
L
A
Q
E
N
G
W
G
V
M
V
S
H
R
S
G
-
E
T
E
D
T
F
I
A
D
L
V
V
G
L
C
T
G
Q
I
K
T
G
A
P
C
R
S
E
R
L
A
K
Y
N
Q
L
M
R
I
E
E
E
L
G
D
E
A
R
F
A
G
H
N
--------
89
PsiBlast_CBE
80.01
50%
-59
- C1 -
7ENL
2
ENO1_YEAST
A:
[2-432]
---
V
S
K
V
Y
A
R
S
V
Y
D
S
R
G
N
P
T
V
E
V
E
L
T
T
E
K
G
V
----------
F
-
R
S
I
V
P
S
G
A
-
S
T
G
V
H
E
A
L
E
M
R
D
G
D
K
S
K
W
M
G
K
G
V
L
H
A
V
K
N
V
N
D
V
I
A
P
A
F
V
K
A
N
--
I
D
V
S
D
Q
K
A
V
D
D
F
L
I
S
L
D
G
T
A
N
K
S
K
L
G
A
N
A
I
L
G
V
S
L
A
A
S
R
A
A
A
A
E
K
N
V
P
L
Y
K
H
---
L
A
D
L
S
-----
K
---
S
KTSP
Y
V
-
L
P
V
P
F
L
N
V
L
N
G
G
S
H
A
G
G
A
L
A
L
Q
E
F
M
I
A
P
T
G
A
K
T
---
F
A
E
---
A
L
R
I
G
S
E
V
Y
H
N
----
L
K
S
L
T
K
K
R
Y-
G
--
A
S
-
A
G
N
V
G
D
E
G
G
V
A
P
N
I
Q
T
A
E
E
A
L
D
-
L
I
V
D
A
I
K
A
A
G
H
D
--
G
K
-
V
K
I
G
L
D
C
A
S
S
E
F
F
--
K
D
G
-----
K
Y
D
---
L
--------
D
F
--------
K
N
-
P
N
S
DKSKWL
T
G
-
P
Q
L
A
D
L
Y
H
S
L
M
K
R
Y
P
I
V
S
I
E
D
P
F
A
E
D
D
W
E
A
W
S
H
F
F
K
T
A
G
--
I
Q
I
V
A
D
D
L
T
V
T
N
P
K
R
I
A
T
A
I
E
K
K
A
A
D
A
L
L
L
K
V
N
Q
I
G
T
L
S
E
S
I
K
A
A
Q
D
S
F
A
A
G
W
G
V
M
V
S
H
R
S
G
-
E
T
E
D
T
F
I
A
D
L
V
V
G
L
R
T
G
Q
I
K
T
G
A
P
A
R
S
E
R
L
A
K
L
N
Q
L
L
R
I
E
E
E
L
G
D
N
A
V
F
A
G
E
N
F
H
-
H
----
59
PsiBlast_CBE
79.97
51%
-66
- C1 -
3UJR
4
ENOG_HUMAN
A:
[2-426]
---
I
E
K
I
W
A
R
E
I
L
D
S
R
G
N
P
T
V
E
V
D
L
Y
T
A
K
G
L
----------
F
-
R
A
A
V
P
S
G
A
-
S
T
G
I
Y
E
A
L
E
L
R
D
G
D
K
Q
R
Y
L
G
K
G
V
L
K
A
V
D
H
I
N
S
T
I
A
P
A
L
I
S
S
G
--
L
S
V
V
E
Q
E
K
L
D
N
L
M
L
E
L
D
G
T
E
N
K
S
K
F
G
A
N
A
I
L
G
V
S
L
A
V
C
K
A
G
A
A
E
R
E
L
P
L
Y
R
H
---
I
A
Q
L
A
-----
G
---
N
S
D
L
--
I
-
L
P
V
P
A
F
N
V
I
N
G
G
S
H
A
G
N
K
L
A
M
Q
E
F
M
I
L
P
V
G
A
E
S
---
F
R
D
---
A
M
R
L
G
A
E
V
Y
H
T
----
L
K
G
V
I
K
D
K
Y-
G
--
K
D
A
T
N
-
V
G
D
E
G
G
F
A
P
N
I
L
E
N
S
E
A
L
E
-
L
V
K
E
A
I
D
K
A
G
Y
T
--
E
K
-
I
V
I
G
M
D
V
A
A
S
E
F
Y
--
R
D
G
-----
K
Y
D
---
L
--------
D
F
--------
K
S
-
P
T
D
PSRYI-
T
G
-
D
Q
L
G
A
L
Y
Q
D
F
V
R
D
Y
P
V
V
S
I
E
D
P
F
D
Q
D
D
W
A
A
W
S
K
F
T
A
N
V
G
--
I
Q
I
V
G
D
D
L
T
V
T
N
P
K
R
I
E
R
A
V
E
E
K
A
C
N
C
L
L
L
K
V
N
Q
I
G
S
V
T
E
A
I
Q
A
C
K
L
A
Q
E
N
G
W
G
V
M
V
S
H
R
S
G
-
E
T
E
D
T
F
I
A
D
L
V
V
G
L
C
T
G
Q
I
K
T
G
A
P
C
R
S
E
R
L
A
K
Y
N
Q
L
M
R
I
E
E
E
L
G
D
E
A
R
F
A
G
H
N
--------
20
PsiBlast_PDB
79.89
51%
-62
- C1 -
3UCD
3
ENOG_HUMAN
A:
[2-426]
---
I
Q
K
I
W
A
R
E
I
L
D
S
R
G
N
P
T
V
E
V
D
L
Y
T
A
K
G
L
----------
F
-
R
A
A
V
P
S
G
A
-
S
T
G
I
Y
E
A
L
E
L
R
D
G
D
K
Q
R
Y
L
G
K
G
V
L
K
A
V
D
H
I
N
S
T
I
A
P
A
L
I
S
S
G
--
L
S
V
V
E
Q
E
K
L
D
N
L
M
L
E
L
D
G
T
E
N
K
S
K
F
G
A
N
A
I
L
G
V
S
L
A
V
C
K
A
G
A
A
E
R
E
L
P
L
Y
R
H
---
I
A
Q
L
A
-----
G
---
N
S
D
L
--
I
-
L
P
V
P
A
F
N
V
I
N
G
G
S
H
A
G
N
K
L
A
M
Q
E
F
M
I
L
P
V
G
A
E
S
---
F
R
D
---
A
M
R
L
G
A
E
V
Y
H
T
----
L
K
G
V
I
K
D
K
Y-
G
--
K
D
A
T
N
-
V
G
D
E
G
G
F
A
P
N
I
L
E
N
S
E
A
L
E
-
L
V
K
E
A
I
D
K
A
G
Y
T
--
E
K
-
I
V
I
G
M
D
V
A
A
S
E
F
Y
--
R
D
G
-----
K
Y
D
---
L
--------
D
F
--------
K
S
-
P
T
D
PSRYI-
T
G
-
D
Q
L
G
A
L
Y
Q
D
F
V
R
D
Y
P
V
V
S
I
E
D
P
F
D
Q
D
D
W
A
A
W
S
K
F
T
A
N
V
G
--
I
Q
I
V
G
D
D
L
T
V
T
N
P
K
R
I
E
R
A
V
E
E
K
A
C
N
C
L
L
L
K
V
N
Q
I
G
S
V
T
E
A
I
Q
A
C
K
L
A
Q
E
N
G
W
G
V
M
V
S
H
R
S
G
-
E
T
E
D
T
F
I
A
D
L
V
V
G
L
C
T
G
Q
I
K
T
G
A
P
C
R
S
E
R
L
A
K
Y
N
Q
L
M
R
I
E
E
E
L
G
D
E
A
R
F
A
G
H
N
--------
55
PsiBlast_CBE
79.88
51%
-64
- C1 -
3UCC
3
ENOG_HUMAN
B:
[2-426]
---
I
Q
K
I
W
A
R
E
I
L
D
S
R
G
N
P
T
V
E
V
D
L
Y
T
A
K
G
L
----------
F
-
R
A
A
V
P
S
G
A
-
S
T
G
I
Y
E
A
L
E
L
R
D
G
D
K
Q
R
Y
L
G
K
G
V
L
K
A
V
D
H
I
N
S
T
I
A
P
A
L
I
SS
G
--
L
S
V
V
E
Q
E
K
L
D
N
L
M
L
E
L
D
G
T
E
N
K
S
K
F
G
A
N
A
I
L
G
V
S
L
A
V
C
K
A
G
A
A
E
R
E
L
P
L
Y
R
H
---
I
A
Q
L
A
-----
G
---
N
SDL--
I
-
L
P
V
P
A
F
N
V
I
N
G
G
S
H
A
G
N
K
L
A
M
Q
E
F
M
I
L
P
V
G
A
E
S
---
F
R
D
---
A
M
R
L
G
A
E
V
Y
H
T
----
L
K
G
V
I
K
D
K
Y-
G
--
K
D
A
T
N
-
V
G
D
E
G
G
F
A
P
N
I
L
E
N
S
E
A
L
E
-
L
V
K
E
A
I
D
K
A
G
Y
T
--
E
K
-
I
V
I
G
M
D
V
A
A
S
E
F
Y
--
R
D
G
-----
K
Y
D
---
L
--------
D
F
--------
K
S
-
P
T
D
PSRYI-
T
G
-
D
Q
L
G
A
L
Y
Q
D
F
V
R
D
Y
P
V
V
S
I
E
D
P
F
D
Q
D
D
W
A
A
W
S
K
F
T
A
N
V
G
--
I
Q
I
V
G
D
D
L
T
V
T
N
P
K
R
I
E
R
A
V
E
E
K
A
C
N
C
L
L
L
K
V
N
Q
I
G
S
V
T
E
A
I
Q
A
C
K
L
A
Q
E
N
G
W
G
V
M
V
S
H
R
S
G
-
E
T
E
D
T
F
I
A
D
L
V
V
G
L
C
T
G
Q
I
K
T
G
A
P
C
R
S
E
R
L
A
K
Y
N
Q
L
M
R
I
E
E
E
L
G
D
E
A
R
F
A
G
H
N
--------
19
PsiBlast_PDB
79.64
51%
-63
- C1 -
3UCC
4
ENOG_HUMAN
A:
[2-426]
---
I
Q
K
I
W
A
R
E
I
L
D
S
R
G
N
P
T
V
E
V
D
L
Y
T
A
K
G
L
----------
F
-
R
A
A
V
P
S
G
A
-
S
T
G
I
Y
E
A
L
E
L
R
D
G
D
K
Q
R
Y
L
G
K
G
V
L
K
A
V
D
H
I
N
S
T
I
A
P
A
L
I
S
S
G
--
L
S
V
V
E
Q
E
K
L
D
N
L
M
L
E
L
D
G
T
E
N
K
S
K
F
G
A
N
A
I
L
G
V
S
L
A
V
C
K
A
G
A
A
E
R
E
L
P
L
Y
R
H
---
I
A
Q
L
A
-----
G
---
N
S
D
L
--
I
-
L
P
V
P
A
F
N
V
I
N
G
G
S
H
A
G
N
K
L
A
M
Q
E
F
M
I
L
P
V
G
A
E
S
---
F
R
D
---
A
M
R
L
G
A
E
V
Y
H
T
----
L
K
G
V
I
K
D
K
Y-
G
--
K
D
A
T
N
-
V
G
D
E
G
G
F
A
P
N
I
L
E
N
S
E
A
L
E
-
L
V
K
E
A
I
D
K
A
G
Y
T
--
E
K
-
I
V
I
G
M
D
V
A
A
S
E
F
Y
--
R
D
G
-----
K
Y
D
---
L
--------
D
F
--------
K
S
-
P
T
D
PSRYI-
T
G
-
D
Q
L
G
A
L
Y
Q
D
F
V
R
D
Y
P
V
V
S
I
E
D
P
F
D
Q
D
D
W
A
A
W
S
K
F
T
A
N
V
G
--
I
Q
I
V
G
D
D
L
T
V
T
N
P
K
R
I
E
R
A
V
E
E
K
A
C
N
C
L
L
L
K
V
N
Q
I
G
S
V
T
E
A
I
Q
A
C
K
L
A
Q
E
N
G
W
G
V
M
V
S
H
R
S
G
-
E
T
E
D
T
F
I
A
D
L
V
V
G
L
C
T
G
Q
I
K
T
G
A
P
C
R
S
E
R
L
A
K
Y
N
Q
L
M
R
I
E
E
E
L
G
D
E
A
R
F
A
G
H
N
--------
61
PsiBlast_CBE
79.57
51%
-62
- C1 -
3UJF
3
ENOG_HUMAN
A:
[2-426]
---
I
E
K
I
W
A
R
E
I
L
D
S
R
G
N
P
T
V
E
V
D
L
Y
T
A
K
G
L
----------
F
-
R
A
A
V
P
S
G
A
-
S
T
G
I
Y
E
A
L
E
L
R
D
G
D
K
Q
R
Y
L
G
K
G
V
L
K
A
V
D
H
I
N
S
T
I
A
P
A
L
I
S
S
G
--
L
S
V
V
E
Q
E
K
L
D
N
L
M
L
E
L
D
G
T
E
N
K
S
K
F
G
A
N
A
I
L
G
V
S
L
A
V
C
K
A
G
A
A
E
R
E
L
P
L
Y
R
H
---
I
A
Q
L
A
-----
G
---
N
SDL--
I
-
L
P
V
P
A
F
N
V
I
N
G
G
S
H
A
G
N
K
L
A
M
Q
E
F
M
I
L
P
V
G
A
E
S
---
F
R
D
---
A
M
R
L
G
A
E
V
Y
H
T
----
L
K
G
V
I
K
D
K
Y-
G
--
K
D
A
T
N
-
V
G
D
E
G
G
F
A
P
N
I
L
E
N
S
E
A
L
E
-
L
V
K
E
A
I
D
K
A
G
Y
T
--
E
K
-
I
V
I
G
M
D
V
A
A
S
E
F
Y
--
R
D
G
-----
K
Y
D
---
L
--------
D
F
--------
K
S
-
P
T
D
PSRYI-
T
G
-
D
Q
L
G
A
L
Y
Q
D
F
V
R
D
Y
P
V
V
S
I
E
D
P
F
D
Q
D
D
W
A
A
W
S
K
F
T
A
N
V
G
--
I
Q
I
V
G
D
D
L
T
V
T
N
P
K
R
I
E
R
A
V
E
E
K
A
C
N
C
L
L
L
K
V
N
Q
I
G
S
V
T
E
A
I
Q
A
C
K
L
A
Q
E
N
G
W
G
V
M
V
S
H
R
S
G
-
E
T
E
D
T
F
I
A
D
L
V
V
G
L
C
T
G
Q
I
K
T
G
A
P
C
R
S
E
R
L
A
K
Y
N
Q
L
M
R
I
E
E
E
L
G
D
E
A
R
F
A
G
H
N
--------
62
PsiBlast_CBE
79.42
51%
-63
- C1 -
3UJE
3
ENOG_HUMAN
B:
[2-426]
---
I
E
K
I
W
A
R
E
I
L
D
S
R
G
N
P
T
V
E
V
D
L
Y
T
A
K
G
L
----------
F
-
R
A
A
V
P
S
G
A
-
S
T
G
I
Y
E
A
L
E
L
R
D
G
D
K
Q
R
Y
L
G
K
G
V
L
K
A
V
D
H
I
N
S
T
I
A
P
A
L
I
SS
G
--
L
S
V
V
E
Q
E
K
L
D
N
L
M
L
E
L
D
G
T
E
N
K
S
K
F
G
A
N
A
I
L
G
V
S
L
A
V
C
K
A
G
A
A
E
R
E
L
P
L
Y
R
H
---
I
A
Q
L
A
-----
G
---
N
SDL--
I
-
L
P
V
P
A
F
N
V
I
N
G
G
S
H
A
G
N
K
L
A
M
Q
E
F
M
I
L
P
V
G
A
E
S
---
F
R
D
---
A
M
R
L
G
A
E
V
Y
H
T
----
L
K
G
V
I
K
D
K
Y-
G
--
K
D
A
T
N
-
V
G
D
E
G
G
F
A
P
N
I
L
E
N
S
E
A
L
E
-
L
V
K
E
A
I
D
K
A
G
Y
T
--
E
K
-
I
V
I
G
M
D
V
A
A
S
E
F
Y
--
R
D
G
-----
K
Y
D
---
L
--------
D
F
--------
K
S
-
P
T
D
PSRYI-
T
G
-
D
Q
L
G
A
L
Y
Q
D
F
V
R
D
Y
P
V
V
S
I
E
D
P
F
D
Q
D
D
W
A
A
W
S
K
F
T
A
N
V
G
--
I
Q
I
V
G
D
D
L
T
V
T
N
P
K
R
I
E
R
A
V
E
E
K
A
C
N
C
L
L
L
K
V
N
Q
I
G
S
V
T
E
A
I
Q
A
C
K
L
A
Q
E
N
G
W
G
V
M
V
S
H
R
S
G
-
E
T
E
D
T
F
I
A
D
L
V
V
G
L
C
T
G
Q
I
K
T
G
A
P
C
R
S
E
R
L
A
K
Y
N
Q
L
M
R
I
E
E
E
L
G
D
E
A
R
F
A
G
H
N
--------
63
PsiBlast_CBE
79.34
51%
-63
- C1 -
3UJE
4
ENOG_HUMAN
A:
[2-426]
---
I
E
K
I
W
A
R
E
I
L
D
S
R
G
N
P
T
V
E
V
D
L
Y
T
A
K
G
L
----------
F
-
R
A
A
V
P
S
G
A
-
S
T
G
I
Y
E
A
L
E
L
R
D
G
D
K
Q
R
Y
L
G
K
G
V
L
K
A
V
D
H
I
N
S
T
I
A
P
A
L
I
S
S
G
--
L
S
V
V
E
Q
E
K
L
D
N
L
M
L
E
L
D
G
T
E
N
K
S
K
F
G
A
N
A
I
L
G
V
S
L
A
V
C
K
A
G
A
A
E
R
E
L
P
L
Y
R
H
---
I
A
Q
L
A
-----
G
---
N
S
D
L
--
I
-
L
P
V
P
A
F
N
V
I
N
G
G
S
H
A
G
N
K
L
A
M
Q
E
F
M
I
L
P
V
G
A
E
S
---
F
R
D
---
A
M
R
L
G
A
E
V
Y
H
T
----
L
K
G
V
I
K
D
K
Y-
G
--
K
D
A
T
N
-
V
G
D
E
G
G
F
A
P
N
I
L
E
N
S
E
A
L
E
-
L
V
K
E
A
I
D
K
A
G
Y
T
--
E
K
-
I
V
I
G
M
D
V
A
A
S
E
F
Y
--
R
D
G
-----
K
Y
D
---
L
--------
D
F
--------
K
S
-
P
T
D
PSRYI-
T
G
-
D
Q
L
G
A
L
Y
Q
D
F
V
R
D
Y
P
V
V
S
I
E
D
P
F
D
Q
D
D
W
A
A
W
S
K
F
T
A
N
V
G
--
I
Q
I
V
G
D
D
L
T
V
T
N
P
K
R
I
E
R
A
V
E
E
K
A
C
N
C
L
L
L
K
V
N
Q
I
G
S
V
T
E
A
I
Q
A
C
K
L
A
Q
E
N
G
W
G
V
M
V
S
H
R
S
G
-
E
T
E
D
T
F
I
A
D
L
V
V
G
L
C
T
G
Q
I
K
T
G
A
P
C
R
S
E
R
L
A
K
Y
N
Q
L
M
R
I
E
E
E
L
G
D
E
A
R
F
A
G
H
N
--------
96
PsiBlast_CBE
79.19
50%
-63
- C1 -
2ONE
2
ENO1_YEAST
B:
[2-432]
---
V
S
K
V
Y
A
R
S
V
Y
D
S
R
G
N
P
T
V
E
V
E
L
T
T
E
K
G
V
----------
F
-
R
S
I
V
P
S
G
A
-
S
T
G
V
H
E
A
L
E
M
R
D
G
D
K
S
K
W
M
G
K
G
V
L
H
A
V
K
N
V
N
D
V
I
A
P
A
F
V
KA
N
--
I
D
V
K
D
Q
K
A
V
D
D
F
L
I
S
L
D
G
T
A
N
K
S
K
L
G
A
N
A
I
L
G
V
S
L
A
A
S
R
A
A
A
A
E
K
N
V
P
L
Y
K
H
---
L
A
D
L
S
-----
K
---
S
KTSPY
V
-
L
P
V
P
F
L
N
V
L
N
G
G
S
H
A
G
G
A
L
A
L
Q
E
F
M
I
A
P
T
G
A
K
T
---
F
A
E
---
A
L
R
I
G
S
E
V
Y
H
N
----
L
K
S
L
T
K
K
R
Y-
G
--
A
S
-
A
G
N
V
G
D
E
G
G
V
A
P
N
I
Q
T
A
E
E
A
L
D
-
L
I
V
D
A
I
K
A
A
G
H
D
--
G
K
-
V
K
I
G
L
D
C
A
S
S
E
F
F
--
K
D
G
-----
K
Y
D
---
L
--------
D
F
--------
K
N
-
P
N
S
DKSKWL
T
G
-
P
Q
L
A
D
L
Y
H
S
L
M
K
R
Y
P
I
V
S
I
E
D
P
F
A
E
D
D
W
E
A
W
S
H
F
F
K
T
A
G
--
I
Q
I
V
A
D
D
L
T
V
T
N
P
K
R
I
A
T
A
I
E
K
K
A
A
D
A
L
L
L
K
V
N
Q
I
G
T
L
S
E
S
I
K
A
A
Q
D
S
F
A
A
G
W
G
V
M
V
S
H
R
S
G
-
E
T
E
D
T
F
I
A
D
L
V
V
G
L
R
T
G
Q
I
K
T
G
A
P
A
R
S
E
R
L
A
K
L
N
Q
L
L
R
I
E
E
E
L
G
D
N
A
V
F
A
G
E
N
F
H
-
H
----
58
PsiBlast_CBE
79.19
51%
-67
- C1 -
3UJR
3
ENOG_HUMAN
B:
[2-426]
---
I
E
K
I
W
A
R
E
I
L
D
S
R
G
N
P
T
V
E
V
D
L
Y
T
A
K
G
L
----------
F
-
R
A
A
V
P
S
G
A
-
S
T
G
I
Y
E
A
L
E
L
R
D
G
D
K
Q
R
Y
L
G
K
G
V
L
K
A
V
D
H
I
N
S
T
I
A
P
A
L
I
SS
G
--
L
S
V
V
E
Q
E
K
L
D
N
L
M
L
E
L
D
G
T
E
N
K
S
K
F
G
A
N
A
I
L
G
V
S
L
A
V
C
K
A
G
A
A
E
R
E
L
P
L
Y
R
H
---
I
A
Q
L
A
-----
G
---
N
SDL--
I
-
L
P
V
P
A
F
N
V
I
N
G
G
S
H
A
G
N
K
L
A
M
Q
E
F
M
I
L
P
V
G
A
E
S
---
F
R
D
---
A
M
R
L
G
A
E
V
Y
H
T
----
L
K
G
V
I
K
D
K
Y-
G
--
K
D
A
T
N
-
V
G
D
E
G
G
F
A
P
N
I
L
E
N
S
E
A
L
E
-
L
V
K
E
A
I
D
K
A
G
Y
T
--
E
K
-
I
V
I
G
M
D
V
A
A
S
E
F
Y
--
R
D
G
-----
K
Y
D
---
L
--------
D
F
--------
K
S
-
P
T
D
PSRYI-
T
G
-
D
Q
L
G
A
L
Y
Q
D
F
V
R
D
Y
P
V
V
S
I
E
D
P
F
D
Q
D
D
W
A
A
W
S
K
F
T
A
N
V
G
--
I
Q
I
V
G
D
D
L
T
V
T
N
P
K
R
I
E
R
A
V
E
E
K
A
C
N
C
L
L
L
K
V
N
Q
I
G
S
V
T
E
A
I
Q
A
C
K
L
A
Q
E
N
G
W
G
V
M
V
S
H
R
S
G
-
E
T
E
D
T
F
I
A
D
L
V
V
G
L
C
T
G
Q
I
K
T
G
A
P
C
R
S
E
R
L
A
K
Y
N
Q
L
M
R
I
E
E
E
L
G
D
E
A
R
F
A
G
H
N
--------
120
HHSearch
78.55
50%
-54
* C1 *
2AL1
3
ENO1_YEAST
A:
[1-429]
--
A
V
S
K
V
Y
A
R
S
V
Y
D
S
R
G
N
P
T
V
E
V
E
L
T
T
E
K
G
V
-----------
F
-
R
S
I
V
P
S
G
A
S
T
G
V
H
E
A
L
E
M
R
D
G
D
K
S
K
W
M
G
K
G
V
L
H
A
V
K
N
V
N
D
V
I
A
P
A
F
V
--
K
A
N
I
D
V
K
D
Q
K
A
V
D
D
F
L
I
S
L
D
G
T
A
N
K
S
K
L
G
A
N
A
I
L
G
V
S
L
A
A
S
R
A
A
A
A
E
K
N
V
P
L
Y
K
H
---
L
A
D
L
S
KSKTS
P
---
Y
-----
V
-
L
P
V
P
F
L
N
V
L
N
G
G
S
H
A
G
G
A
L
A
L
Q
E
F
M
I
A
P
T
G
A
K
T
F
A
E
A
L
R
---
I
G
S
E
V
---
Y
H
N
----
L
K
S
L
T
K
K
R
Y-
G
A-
S
A
-
G
N
-
V
G
D
E
G
G
V
A
P
N
I
Q
T
A
E
E
A
L
D
-
L
I
V
D
A
I
K
A
A
G
H
--
D
G
K
-
V
K
I
G
L
D
C
A
S
S
E
F
F
K
D
--
G
-----
K
Y
D
---
L
--------
D
F
KNPNSD--
K
S
-
K
W
L
------
T
G
-
P
Q
L
A
D
L
Y
H
S
L
M
K
R
Y
P
I
V
S
I
E
D
P
F
A
E
D
D
W
E
A
W
S
H
F
F
K
T
A
--
G
I
Q
I
V
A
D
D
L
T
V
T
N
P
K
R
I
A
T
A
I
E
K
K
A
A
D
A
L
L
L
K
V
N
Q
I
G
T
L
S
E
S
I
K
A
A
Q
D
S
F
A
A
G
W
G
V
M
V
S
H
R
S
G
-
E
T
E
D
T
F
I
A
D
L
V
V
G
L
R
T
G
Q
I
K
T
G
A
P
A
R
S
E
R
L
A
K
L
N
Q
L
L
R
I
E
E
E
L
G
D
N
A
V
F
A
G
E
N
--------
60
PsiBlast_CBE
78.46
51%
-63
- C1 -
3UJF
3
ENOG_HUMAN
B:
[2-426]
---
I
E
K
I
W
A
R
E
I
L
D
S
R
G
N
P
T
V
E
V
D
L
Y
T
A
K
G
L
----------
F
-
R
A
A
V
P
S
G
A
-
S
T
G
I
Y
E
A
L
E
L
R
D
G
D
K
Q
R
Y
L
G
K
G
V
L
K
A
V
D
H
I
N
S
T
I
A
P
A
L
I
SS
G
--
L
S
V
V
E
Q
E
K
L
D
N
L
M
L
E
L
D
G
T
E
N
K
S
K
F
G
A
N
A
I
L
G
V
S
L
A
V
C
K
A
G
A
A
E
R
E
L
P
L
Y
R
H
---
I
A
Q
L
A
-----
G
---
N
SDL--
I
-
L
P
V
P
A
F
N
V
I
N
G
G
S
H
A
G
N
K
L
A
M
Q
E
F
M
I
L
P
V
G
A
E
S
---
F
R
D
---
A
M
R
L
G
A
E
V
Y
H
T
----
L
K
G
V
I
K
D
K
Y-
G
--
K
D
A
T
N
-
V
G
D
E
G
G
F
A
P
N
I
L
E
N
S
E
A
L
E
-
L
V
K
E
A
I
D
K
A
G
Y
T
--
E
K
-
I
V
I
G
M
D
V
A
A
S
E
F
Y
--
R
D
G
-----
K
Y
D
---
L
--------
D
F
--------
K
S
-
P
T
D
PSRYI-
T
G
-
D
Q
L
G
A
L
Y
Q
D
F
V
R
D
Y
P
V
V
S
I
E
D
P
F
D
Q
D
D
W
A
A
W
S
K
F
T
A
N
V
G
--
I
Q
I
V
G
D
D
L
T
V
T
N
P
K
R
I
E
R
A
V
E
E
K
A
C
N
C
L
L
L
K
V
N
Q
I
G
S
V
T
E
A
I
Q
A
C
K
L
A
Q
E
N
G
W
G
V
M
V
S
H
R
S
G
-
E
T
E
D
T
F
I
A
D
L
V
V
G
L
C
T
G
Q
I
K
T
G
A
P
C
R
S
E
R
L
A
K
Y
N
Q
L
M
R
I
E
E
E
L
G
D
E
A
R
F
A
G
H
N
--------
56
PsiBlast_CBE
78.44
51%
-65
- C1 -
3UJS
3
ENOG_HUMAN
B:
[2-426]
---
I
E
K
I
W
A
R
E
I
L
D
S
R
G
N
P
T
V
E
V
D
L
Y
T
A
K
G
L
----------
F
-
R
A
A
V
P
S
G
A
-
S
T
G
I
Y
E
A
L
E
L
R
D
G
D
K
Q
R
Y
L
G
K
G
V
L
K
A
V
D
H
I
N
S
T
I
A
P
A
L
I
SS
G
--
L
S
V
V
E
Q
E
K
L
D
N
L
M
L
E
L
D
G
T
E
N
K
S
K
F
G
A
N
A
I
L
G
V
S
L
A
V
C
K
A
G
A
A
E
R
E
L
P
L
Y
R
H
---
I
A
Q
L
A
-----
G
---
N
SDL--
I
-
L
P
V
P
A
F
N
V
I
N
G
G
S
H
A
G
N
K
L
A
M
Q
E
F
M
I
L
P
V
G
A
E
S
---
F
R
D
---
A
M
R
L
G
A
E
V
Y
H
T
----
L
K
G
V
I
K
D
K
Y-
G
--
K
D
A
T
N
-
V
G
D
E
G
G
F
A
P
N
I
L
E
N
S
E
A
L
E
-
L
V
K
E
A
I
D
K
A
G
Y
T
--
E
K
-
I
V
I
G
M
D
V
A
A
S
E
F
Y
--
R
D
G
-----
K
Y
D
---
L
--------
D
F
--------
K
S
-
P
T
D
PSRYI-
T
G
-
D
Q
L
G
A
L
Y
Q
D
F
V
R
D
Y
P
V
V
S
I
E
D
P
F
D
Q
D
D
W
A
A
W
S
K
F
T
A
N
V
G
--
I
Q
I
V
G
D
D
L
T
V
T
N
P
K
R
I
E
R
A
V
E
E
K
A
C
N
C
L
L
L
K
V
N
Q
I
G
S
V
T
E
A
I
Q
A
C
K
L
A
Q
E
N
G
W
G
V
M
V
S
H
R
S
G
-
E
T
E
D
T
F
I
A
D
L
V
V
G
L
C
T
G
Q
I
K
T
G
A
P
C
R
S
E
R
L
A
K
Y
N
Q
L
M
R
I
E
E
E
L
G
D
E
A
R
F
A
G
H
N
--------
86
PsiBlast_CBE
78.25
52%
-61
- C1 -
2PTY
4
?
A:
[6-426]
---
I
Q
K
V
H
G
R
E
V
L
D
S
R
G
N
P
T
V
E
V
E
V
T
T
E
K
G
V
----------
F
-
R
S
A
V
P
S
G
A
-
S
T
G
V
Y
E
A
C
E
L
R
D
G
D
K
K
R
Y
V
G
K
G
C
L
Q
A
V
K
N
V
N
E
V
I
G
P
A
L
I
--
G
--
R
D
E
L
K
Q
E
E
L
D
T
L
M
L
R
L
D
G
T
P
N
K
G
K
L
G
A
N
A
I
L
G
C
S
M
A
I
S
K
A
A
A
A
A
K
G
V
P
L
Y
R
Y
---
L
A
S
L
A
-----
G
---
T
K
E
L
--
R
-
L
P
V
P
C
F
N
V
I
N
G
G
K
H
A
G
N
A
L
P
F
Q
E
F
M
I
A
P
V
K
A
T
S
---
F
S
E
---
A
L
R
M
G
S
E
V
Y
H
S
----
L
R
G
I
I
K
K
K
Y-
G
--
Q
D
A
V
N
-
V
G
D
E
G
G
F
A
P
P
I
K
D
I
N
E
P
L
P
-
I
L
M
E
A
I
E
E
A
G
H
R
--
G
K
-
F
A
I
C
M
D
C
A
A
S
E
T
Y
D
E
K
K
Q
-----
Q
Y
N
---
L
TFK-----
S
P
--------
E
P
-
T
W
V
------
T
A
-
E
Q
L
R
E
T
Y
C
K
W
A
H
D
Y
P
I
V
S
I
E
D
P
Y
D
Q
D
D
F
A
G
F
A
G
I
T
E
A
L
K
G
K
T
Q
I
V
G
D
D
L
T
V
T
N
T
E
R
I
K
M
A
I
E
K
K
A
C
N
S
L
L
L
K
I
N
Q
I
G
T
I
S
E
A
I
A
S
S
K
L
C
M
E
N
G
W
S
V
M
V
S
H
R
S
G
-
E
T
E
D
T
Y
I
A
D
L
V
V
A
L
G
S
G
Q
I
K
T
G
A
P
C
R
G
E
R
T
A
K
L
N
Q
L
L
R
I
E
E
E
L
G
A
H
A
K
F
------------
83
PsiBlast_CBE
78.17
52%
-61
- C1 -
2PU1
5
?
A:
[6-426]
---
I
Q
K
V
H
G
R
E
V
L
D
S
R
G
N
P
T
V
E
V
E
V
T
T
E
K
G
V
----------
F
-
R
S
A
V
P
S
G
A
-
S
T
G
V
Y
E
A
C
E
L
R
D
G
D
K
K
R
Y
V
G
K
G
C
L
Q
A
V
K
N
V
N
E
V
I
G
P
A
L
I
--
G
--
R
D
E
L
K
Q
E
E
L
D
T
L
M
L
R
L
D
G
T
P
N
K
G
K
L
G
A
N
A
I
L
G
C
S
M
A
I
S
K
A
A
A
A
A
K
G
V
P
L
Y
R
Y
---
L
A
S
L
A
-----
G
---
T
K
E
L
--
R
-
L
P
V
P
C
F
N
V
I
N
G
G
K
H
A
G
N
A
L
P
F
Q
E
F
M
I
A
P
V
K
A
T
S
---
F
S
E
---
A
L
R
M
G
S
E
V
Y
H
S
----
L
R
G
I
I
K
K
K
Y-
G
--
Q
D
A
V
N
-
V
G
D
E
G
G
F
A
P
P
I
K
D
I
N
E
P
L
P
-
I
L
M
E
A
I
E
E
A
G
H
R
--
G
K
-
F
A
I
C
M
D
C
A
A
S
E
T
Y
D
E
K
K
Q
-----
Q
Y
N
---
L
TFK-----
S
P
--------
E
P
-
T
W
V
------
T
A
-
E
Q
L
R
E
T
Y
C
K
W
A
H
D
Y
P
I
V
S
I
E
D
P
Y
D
Q
D
D
F
A
G
F
A
G
I
T
E
A
L
K
G
K
T
Q
I
V
G
D
D
L
T
V
T
N
T
E
R
I
K
M
A
I
E
K
K
A
C
N
S
L
L
L
K
I
N
Q
I
G
T
I
S
E
A
I
A
S
S
K
L
C
M
E
N
G
W
S
V
M
V
S
H
R
S
G
-
E
T
E
D
T
Y
I
A
D
L
V
V
A
L
G
S
G
Q
I
K
T
G
A
P
C
R
G
E
R
T
A
K
L
N
Q
L
L
R
I
E
E
E
L
G
A
H
A
K
F
------------
85
PsiBlast_CBE
77.97
52%
-61
- C1 -
2PTZ
5
?
A:
[6-426]
---
I
Q
K
V
H
G
R
E
V
L
D
S
R
G
N
P
T
V
E
V
E
V
T
T
E
K
G
V
----------
F
-
R
S
A
V
P
S
G
A
-
S
T
G
V
Y
E
A
C
E
L
R
D
G
D
K
K
R
Y
V
G
K
G
C
L
Q
A
V
K
N
V
N
E
V
I
G
P
A
L
I
--
G
--
R
D
E
L
K
Q
E
E
L
D
T
L
M
L
R
L
D
G
T
P
N
K
G
K
L
G
A
N
A
I
L
G
C
S
M
A
I
S
K
A
A
A
A
A
K
G
V
P
L
Y
R
Y
---
L
A
S
L
A
-----
G
---
T
K
E
L
--
R
-
L
P
V
P
C
F
N
V
I
N
G
G
K
H
A
G
N
A
L
P
F
Q
E
F
M
I
A
P
V
K
A
T
S
---
F
S
E
---
A
L
R
M
G
S
E
V
Y
H
S
----
L
R
G
I
I
K
K
K
Y-
G
--
Q
D
A
V
N
-
V
G
D
E
G
G
F
A
P
P
I
K
D
I
N
E
P
L
P
-
I
L
M
E
A
I
E
E
A
G
H
R
--
G
K
-
F
A
I
C
M
D
C
A
A
S
E
T
Y
D
E
K
K
Q
-----
Q
Y
N
---
L
TFK-----
S
P
--------
E
P
-
T
W
V
------
T
A
-
E
Q
L
R
E
T
Y
C
K
W
A
H
D
Y
P
I
V
S
I
E
D
P
Y
D
Q
D
D
F
A
G
F
A
G
I
T
E
A
L
K
G
K
T
Q
I
V
G
D
D
L
T
V
T
N
T
E
R
I
K
M
A
I
E
K
K
A
C
N
S
L
L
L
K
I
N
Q
I
G
T
I
S
E
A
I
A
S
S
K
L
C
M
E
N
G
W
S
V
M
V
S
H
R
S
G
-
E
T
E
D
T
Y
I
A
D
L
V
V
A
L
G
S
G
Q
I
K
T
G
A
P
C
R
G
E
R
T
A
K
L
N
Q
L
L
R
I
E
E
E
L
G
A
H
A
K
F
------------
84
PsiBlast_CBE
77.90
52%
-62
- C1 -
2PU0
7
?
A:
[6-426]
---
I
Q
K
V
H
G
R
E
V
L
D
S
R
G
N
P
T
V
E
V
E
V
T
T
E
K
G
V
----------
F
-
R
S
A
V
P
S
G
A
-
S
T
G
V
Y
E
A
C
E
L
R
D
G
D
K
K
R
Y
V
G
K
G
C
L
Q
A
V
K
N
V
N
E
V
I
G
P
A
L
I
--
G
--
R
D
E
L
K
Q
E
E
L
D
T
L
M
L
R
L
D
G
T
P
N
K
G
K
L
G
A
N
A
I
L
G
C
S
M
A
I
S
K
A
A
A
A
A
K
G
V
P
L
Y
R
Y
---
L
A
S
L
A
-----
G
---
T
K
E
L
--
R
-
L
P
V
P
C
F
N
V
I
N
G
G
K
H
A
G
N
A
L
P
F
Q
E
F
M
I
A
P
V
K
A
T
S
---
F
S
E
---
A
L
R
M
G
S
E
V
Y
H
S
----
L
R
G
I
I
K
K
K
Y-
G
--
Q
D
A
V
N
-
V
G
D
E
G
G
F
A
P
P
I
K
D
I
N
E
P
L
P
-
I
L
M
E
A
I
E
E
A
G
H
R
--
G
K
-
F
A
I
C
M
D
C
A
A
S
E
T
Y
D
E
K
K
Q
-----
Q
Y
N
---
L
TFK-----
S
P
--------
E
P
-
T
W
V
------
T
A
-
E
Q
L
R
E
T
Y
C
K
W
A
H
D
Y
P
I
V
S
I
E
D
P
Y
D
Q
D
D
F
A
G
F
A
G
I
T
E
A
L
K
G
K
T
Q
I
V
G
D
D
L
T
V
T
N
T
E
R
I
K
M
A
I
E
K
K
A
C
N
S
L
L
L
K
I
N
Q
I
G
T
I
S
E
A
I
A
S
S
K
L
C
M
E
N
G
W
S
V
M
V
S
H
R
S
G
-
E
T
E
D
T
Y
I
A
D
L
V
V
A
L
G
S
G
Q
I
K
T
G
A
P
C
R
G
E
R
T
A
K
L
N
Q
L
L
R
I
E
E
E
L
G
A
H
A
K
F
------------
101
Fugue
77.71
51%
-52
- C1 -
1ONE
3
ENO1_YEAST
A:
[1-436]
--
A
V
S
K
V
Y
A
R
S
V
Y
D
S
R
G
N
P
T
V
E
V
E
L
T
T
E
K
G
-----------
V
F
R
S
I
V
P
S
G
A
-
S
T
G
V
H
E
A
L
E
M
R
D
G
D
K
S
K
W
M
G
K
G
V
L
H
A
V
K
N
V
N
D
V
I
A
P
A
F
V
--
K
A
N
I
D
V
K
D
Q
K
A
V
D
D
F
L
I
S
L
D
G
T
A
N
K
S
K
L
G
A
N
A
I
L
G
V
S
L
A
A
S
R
A
A
A
A
E
K
N
V
P
L
Y
K
H
---
L
A
D
L
S
-----
K
---
S
KTSP
Y
V
-
L
P
V
P
F
L
N
V
L
N
G
G
S
H
A
G
G
A
L
A
L
Q
E
F
M
I
A
P
T
G
A
K
T
---
F
A
E
---
A
L
R
I
G
S
E
V
Y
H
N
----
L
K
S
L
T
K
K
R
YG
A
--
S
A
-
G
N
-
V
G
D
E
G
G
V
A
P
N
I
Q
T
A
E
E
A
L
D
-
L
I
V
D
A
I
K
A
A
G
H
D
G
--
K
-
V
K
I
G
L
D
C
A
S
S
E
F
F
K
D
-
G
K
Y
D
LDF
K
N
P
---
N
--------
S
D
--------
K
S
-
K
W
L
------
T
G
-
P
Q
L
A
D
L
Y
H
S
L
M
K
R
Y
P
I
V
S
I
E
D
P
F
A
E
D
D
W
E
A
W
S
H
F
F
K
T
--
A
G
I
Q
I
V
A
D
D
L
T
V
T
N
P
K
R
I
A
T
A
I
E
K
K
A
A
D
A
L
L
L
K
V
N
Q
I
G
T
L
S
E
S
I
K
A
A
Q
D
S
F
A
A
G
W
G
V
M
V
S
H
R
S
G
-
E
T
E
D
T
F
I
A
D
L
V
V
G
L
R
T
G
Q
I
K
T
G
A
P
A
R
S
E
R
L
A
K
L
N
Q
L
L
R
I
E
E
E
L
G
D
N
A
V
F
A
G
E
N
F
H
-
H
G
D
K
L
118
HHSearch
75.90
51%
-57
- C1 -
3QTP
6
ENO1_ENTHI
A:
[5-439]
S
M
S
I
Q
K
V
H
A
R
E
I
L
D
S
R
G
N
P
T
I
E
V
E
I
T
T
G
K
G
M
F
R
S
C
V
P
S
GAS
T
G
V
H
E
A
V
E
L
R
------------
D
G
D
K
K
R
Y
G
G
K
G
V
L
K
A
V
E
N
V
N
T
I
I
G
P
A
L
L
--
G
--
K
N
V
L
N
Q
A
E
L
D
E
M
M
I
K
L
D
G
T
N
N
K
G
K
L
G
A
N
A
I
L
G
C
S
M
S
I
C
R
A
A
A
A
E
K
G
L
P
L
Y
K
Y
---
L
A
E
L
T
-----
G
HK
E
M
-----
T
-
M
P
V
P
C
F
N
V
I
N
G
G
A
H
A
G
N
A
L
A
M
Q
E
F
M
I
C
P
T
G
A
T
N
---
F
H
E
A
L
R
M
A
A
E
T
---
Y
Q
C
----
L
K
V
V
I
K
A
K
--
Y
GQ
D
A
-
T
N
-
V
G
D
E
G
G
F
A
P
N
V
S
G
A
R
E
A
L
D
L
L
V
E
-
A
I
A
K
A
G
--
Y
T
G
K
-
I
E
I
A
M
D
C
A
A
S
E
F
Y
N
E
E
T
K
-----
K
Y
D
---
L
--------
G
K
KIPADKKD
P
S
-
L
V
K
------
D
V
-
D
G
L
I
A
E
Y
V
D
Y
G
K
H
Y
P
I
A
S
I
E
D
P
F
A
E
D
D
W
A
A
W
N
K
F
T
V
E
H
G
-
N
F
Q
I
V
G
D
D
L
L
V
T
N
P
A
R
V
Q
M
A
M
D
K
N
A
C
N
S
V
L
I
K
V
N
Q
I
G
T
L
T
E
T
F
K
T
I
K
M
A
Q
E
K
G
W
G
V
M
A
S
H
R
S
G
-
E
T
E
D
T
F
I
A
D
L
V
V
G
L
N
C
K
Q
I
K
T
G
A
P
C
R
S
E
R
L
C
K
Y
N
Q
L
M
R
I
E
E
E
L
G
N
-
I
P
Y
A
G
K
N
-
W
-
R
N
S
--
121
HHSearch
73.30
47%
-61
- C1 -
2PTZ
5
?
A:
[3-429]
H
M
T
I
Q
K
V
H
G
R
E
V
L
D
S
R
G
N
P
T
V
E
V
E
V
T
T
E
K
G
V
F
R
S
A
V
P
S
G
AS
T
G
V
Y
E
A
C
E
L
R
-
D
-----------
G
D
K
K
R
Y
V
G
K
G
C
L
Q
A
V
K
N
V
N
E
V
I
G
P
A
L
I
--
G
--
R
D
E
L
K
Q
E
E
L
D
T
L
M
L
R
L
D
G
T
P
N
K
G
K
L
G
A
N
A
I
L
G
C
S
M
A
I
S
K
A
A
A
A
A
K
G
V
P
L
Y
R
Y
---
L
A
S
L
A
GTK--
E
---
L
-----
R
-
L
P
V
P
C
F
N
V
I
N
G
G
K
H
A
G
N
A
L
P
F
Q
E
F
M
I
A
P
V
K
A
T
S
---
F
S
E
A
L
R
M
G
S
E
V
---
Y
H
S
L
R
G
I
I
K
K
K
Y
G
Q
------
D
A
-
V
N
-
V
G
D
E
G
G
F
A
P
P
I
K
D
I
N
E
P
L
P
-
I
L
M
E
A
I
E
E
A
G
H
--
R
G
K
-
F
A
I
C
M
D
C
A
A
S
E
T
Y
D
E
K
K
Q
-----
Q
Y
N
---
L
--------
T
F
KSP-----
E
P
-
T
W
V
------
T
A
-
E
Q
L
R
E
T
Y
C
K
W
A
H
D
Y
P
I
V
S
I
E
D
P
Y
D
Q
D
D
F
A
G
F
A
G
I
T
E
A
L
K
G
K
T
Q
I
V
G
D
D
L
T
V
T
N
T
E
R
I
K
M
A
I
E
K
K
A
C
N
S
L
L
L
K
I
N
Q
I
G
T
I
S
E
A
I
A
S
S
K
L
C
M
E
N
G
W
S
V
M
V
-
S
H
R
S
G
E
T
E
D
T
Y
I
A
D
L
V
V
A
L
G
S
G
Q
I
K
T
G
A
P
C
R
G
E
R
T
A
K
L
N
Q
L
L
R
I
E
E
E
L
G
A
H
A
K
F
G
F
P
---------
80
PsiBlast_CBE
37.45
50%
25
- C1 -
1PDZ
2
ENO_HOMGA
A:
[5-429]
---
I
T
K
V
F
A
R
T
I
F
D
S
R
G
N
P
T
V
E
V
D
L
Y
T
S
K
G
L
----------
F
-
R
A
A
V
P
S
G
A
-
S
T
G
V
H
E
A
L
E
M
R
D
G
D
K
S
K
Y
H
G
K
S
V
F
N
A
V
K
N
V
N
D
V
I
V
P
E
I
I
K
S
G
--
L
K
V
T
Q
Q
K
E
C
D
E
F
M
C
K
L
D
G
T
E
N
K
S
S
L
G
A
N
A
I
L
G
V
S
L
A
I
C
K
A
G
A
A
E
L
G
I
P
L
Y
R
H
I
A
N
L
A
N
Y
D
-----
E
---
V
-----
I
-
L
P
V
P
A
F
N
V
I
N
G
G
S
H
A
G
N
K
L
A
M
Q
E
F
M
I
L
P
T
G
A
T
S
---
F
T
E
---
A
M
R
M
G
T
E
V
Y
H
H
----
L
K
A
V
I
K
A
R
F-
G
--
L
D
A
T
A
-
V
G
D
E
G
G
F
A
P
N
I
L
N
N
K
D
A
L
D
-
L
I
Q
E
A
I
K
K
A
G
Y
T
G
--
K
-
I
E
I
G
M
D
V
A
A
S
E
F
Y
-
K
Q
N
N
-----
I
Y
D
---
L
DFKTA---
N
N
--------
D
G
-
S
Q
K
------
I
S
G
D
Q
L
R
D
M
Y
M
E
F
C
K
D
F
P
I
V
S
I
E
D
P
F
D
Q
D
D
W
E
T
W
S
K
M
T
S
--
G
T
T
I
Q
I
V
G
D
D
L
T
V
T
N
P
K
R
I
T
T
A
V
E
K
K
A
C
K
C
L
L
L
K
V
N
Q
I
G
S
V
T
E
S
I
D
A
H
L
L
A
K
K
N
G
W
G
T
M
V
S
H
R
S
G
-
E
T
E
D
C
F
I
A
D
L
V
V
G
L
C
T
G
Q
I
K
T
G
A
P
C
R
S
E
R
L
A
K
Y
N
Q
I
L
R
I
E
E
E
L
G
S
G
A
K
F
A
G
K
N
--------