@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : Lmo2459: (2016-04-03 )
MTVKVGINGFGRIGRLAFRRIQNVEGIEVVAINDLTDAKMLAHLLKYDTTQGRFDGEVEVHDGFFKVNGKEVKVLANRNPEELPWGDLGVDIVLECTGFFTAQDKAELHIKAGAKKVVISAPATGDMKTIVYNVNHETLDGTETVISGASCTTNCLAPMAKVLEDKFGVVEGLMTTIHAYTGDQNTLDAPHPKGDFRRARAAAENIIPNTTGAAKAIGEVLPTLKGKLDGAAQRVPVPTGSLTELVTVLDKKVTVDEVNAAMEAASDPETFGYTSDQVVSSDIKGMTFGSLFDETQTKVLTVGDQQLVKTVAWYDNEMSYTAQLVRTLEYFAKIAK
Atome Classification :
(28 SA)
.........10........20..--..--.--...30.....-...40........50........60-........70........80........90........100.......110.......120.......130.......140........150.......160.......170.......180.......190.......200.......210.......220.......230.......240.......250.-.......260......-------.---270.......280.......290.......300.......310.......320.......330....
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
M
T
V
K
V
GINGF
G
R
I
G
R
L
A
F
R
R
IQN--VE--
G
--
I
E
V
V
A
INDL
T
-
D
A
K
M
L
A
H
L
L
KYDTTQGRFD
G
E
V
E
V
H-D
G
F
F
K
VNG
K
E
V
K
V
L
ANRNPEELPWGDL
G
V
D
I
V
L
ECTGFFTAQD
K
A
E
L
H
I
KAG
A
K
K
V
V
I
SAPATGD
M
K
T
I
V
Y
NVNHETLDG-
T
E
T
V
ISGASC
T
T
N
C
L
A
P
M
A
K
V
L
E
D
K
F
G
V
V
E
G
L
M
T
T
I
H
AYTGDQNTLDAPHPK
G
D
F
R
R
A
R
A
A
A
E
NIIPNTT
G
A
A
K
A
I
G
E
V
L
P
T
L
KGKLDGAAQRVPVPT
G
S
L
T
E
L
V
T
V
L
DK-K-V
T
V
D
E
V
N
A
A
M
EAASDP-------E---TFGYTS
D
Q
V
V
S
S
DIKGM
T
F
G
S
L
FDETQ
T
K
V
L
T
VG
D
Q
Q
L
V
K
T
V
A
W
YDN
E
M
S
Y
T
A
Q
L
V
R
T
L
E
Y
F
A
K
IAK
41
PsiBlast_CBE
98.75
74%
-96
- C1 -
3LC1
3
G3P1_STAAR
O:
[2-335]
-
A
V
K
V
A
I
N
G
F
G
R
I
G
R
L
A
F
R
R
I
Q
E
--
V
E
--
G
--
L
E
V
V
A
V
N
D
L
T
-
D
D
D
M
L
A
H
L
L
K
Y
D
T
M
Q
G
R
F
T
G
E
V
E
V
V
-
D
G
G
F
R
V
N
G
K
E
V
K
S
F
S
E
P
D
A
S
K
L
P
W
K
D
L
N
I
D
V
V
L
E
C
T
G
F
Y
T
D
K
D
K
A
Q
A
H
I
E
A
G
A
K
K
V
L
I
S
A
P
A
T
G
D
L
K
T
I
V
F
N
T
N
H
Q
E
L
D
G
-
S
E
T
V
V
S
G
A
S
C
T
T
N
S
L
A
P
V
A
K
V
L
N
D
D
F
G
L
V
E
G
L
M
T
T
I
N
A
Y
T
G
D
Q
N
T
Q
D
A
P
H
R
K
G
D
K
R
R
A
R
A
A
A
E
N
I
I
P
N
S
T
G
A
A
K
A
I
G
K
V
I
P
E
I
D
G
K
L
D
G
G
A
Q
R
V
P
V
A
T
G
S
L
T
E
L
T
V
V
L
E
K
-
Q
D
V
T
V
E
Q
V
N
E
A
M
K
N
A
S
N
--------
E
---
S
F
G
Y
T
E
D
E
I
V
S
S
D
V
V
G
M
T
Y
G
S
L
F
D
A
T
Q
T
R
V
M
S
V
G
D
R
Q
L
V
K
V
A
A
W
Y
D
N
E
M
S
Y
T
A
Q
L
V
R
T
L
A
Y
L
A
E
L
S
-
40
PsiBlast_CBE
98.27
74%
-97
- C1 -
3LC1
3
G3P1_STAAR
Q:
[2-335]
-
A
V
K
V
A
I
N
G
F
G
R
I
G
R
L
A
F
R
R
I
Q
E
--
V
E
--
G
--
L
E
V
V
A
V
N
D
L
T
-
D
D
D
M
L
A
H
L
L
K
Y
D
T
M
Q
G
R
F
T
G
E
V
E
V
V
-
D
G
G
F
R
V
N
G
K
E
V
K
S
F
S
E
P
D
A
S
K
L
P
W
K
D
L
N
I
D
V
V
L
E
C
T
G
F
Y
T
D
K
D
K
A
Q
A
H
I
E
A
G
A
K
K
V
L
I
S
A
P
A
T
G
D
L
K
T
I
V
F
N
T
N
H
Q
E
L
D
G
-
S
E
T
V
V
S
G
A
S
C
T
T
N
S
L
A
P
V
A
K
V
L
N
D
D
F
G
L
V
E
G
L
M
T
T
I
N
A
Y
T
G
D
Q
N
T
Q
D
A
P
H
R
K
G
D
K
R
R
A
R
A
A
A
E
N
I
I
P
N
S
T
G
A
A
K
A
I
G
K
V
I
P
E
I
D
G
K
L
D
G
G
A
Q
R
V
P
V
A
T
G
S
L
T
E
L
T
V
V
L
E
K
-
Q
D
V
T
V
E
Q
V
N
E
A
M
K
N
A
S
N
--------
E
---
S
F
G
Y
T
E
D
E
I
V
S
S
D
V
V
G
M
T
Y
G
S
L
F
D
A
T
Q
T
R
V
M
S
V
G
D
R
Q
L
V
K
V
A
A
W
Y
D
N
E
M
S
Y
T
A
Q
L
V
R
T
L
A
Y
L
A
E
L
S
-
120
HHSearch
98.03
75%
-94
- C1 -
3LVF
2
G3P1_STAAR
P:
[3-338]
M
A
V
K
V
A
I
N
G
F
G
R
I
G
R
L
A
F
R
R
I
Q
E
--
V
E
--
G
--
L
E
V
V
A
V
N
D
L
T
-
D
D
D
M
L
A
H
L
L
K
Y
D
T
M
Q
G
R
F
T
G
E
V
E
V
V
-
D
G
G
F
R
V
N
G
K
E
V
K
S
F
S
E
P
D
A
S
K
L
P
W
K
D
L
N
I
D
V
V
L
E
C
T
G
F
Y
T
D
K
D
K
A
Q
A
H
I
E
A
G
A
K
K
V
L
I
S
A
P
A
T
G
D
L
K
T
I
V
F
N
T
N
H
Q
E
L
D
G
-
S
E
T
V
V
S
G
A
S
C
T
T
N
S
L
A
P
V
A
K
V
L
N
D
D
F
G
L
V
E
G
L
M
T
T
I
H
A
Y
T
G
D
Q
N
T
Q
D
A
P
H
R
K
G
D
K
R
R
A
R
A
A
A
E
N
I
I
P
N
S
T
G
A
A
K
A
I
G
K
V
I
P
E
I
D
G
K
L
D
G
G
A
Q
R
V
P
V
A
T
G
S
L
T
E
L
T
V
V
L
E
K
Q
D
-
V
T
V
E
Q
V
N
E
A
M
K
N
A
S
N
E
-----------
S
F
G
Y
T
E
D
E
I
V
S
S
D
V
V
G
M
T
Y
G
S
L
F
D
A
T
Q
T
R
V
M
S
V
G
D
R
Q
L
V
K
V
A
A
W
Y
D
N
E
M
S
Y
T
A
Q
L
V
R
T
L
A
Y
L
A
E
L
S
K
35
PsiBlast_CBE
97.74
74%
-96
- C1 -
3LVF
2
G3P1_STAAR
R:
[4-338]
-
A
V
K
V
A
I
N
G
F
G
R
I
G
R
L
A
F
R
R
I
Q
E
--
V
E
--
G
--
L
E
V
V
A
V
N
D
L
T
-
D
D
D
M
L
A
H
L
L
K
Y
D
T
M
Q
G
R
F
T
G
E
V
E
V
V
-
D
G
G
F
R
V
N
G
K
E
V
K
S
F
S
E
P
D
A
S
K
L
P
W
K
D
L
N
I
D
V
V
L
E
C
T
G
F
Y
T
D
K
D
K
A
Q
A
H
I
E
A
G
A
K
K
V
L
I
S
A
P
A
T
G
D
L
K
T
I
V
F
N
T
N
H
Q
E
L
D
G
-
S
E
T
V
V
S
G
A
S
C
T
T
N
S
L
A
P
V
A
K
V
L
N
D
D
F
G
L
V
E
G
L
M
T
T
I
H
A
Y
T
G
D
Q
N
T
Q
D
A
P
H
R
K
G
D
K
R
R
A
R
A
A
A
E
N
I
I
P
N
S
T
G
A
A
K
A
I
G
K
V
I
P
E
I
D
G
K
L
D
G
G
A
Q
R
V
P
V
A
T
G
S
L
T
E
L
T
V
V
L
E
K
-
Q
D
V
T
V
E
Q
V
N
E
A
M
K
N
A
S
N
--------
E
---
S
F
G
Y
T
E
D
E
I
V
S
S
D
V
V
G
M
T
Y
G
S
L
F
D
A
T
Q
T
R
V
M
S
V
G
D
R
Q
L
V
K
V
A
A
W
Y
D
N
E
M
S
Y
T
A
Q
L
V
R
T
L
A
Y
L
A
E
L
S
K
45
PsiBlast_CBE
97.62
74%
-97
- C1 -
3HQ4
2
G3P1_STAAR
Q:
[1-334]
M
A
V
K
V
A
I
N
G
F
G
R
I
G
R
L
A
F
R
R
I
Q
E
--
V
E
--
G
--
L
E
V
V
A
V
N
D
L
T
-
D
D
D
M
L
A
H
L
L
K
Y
D
T
M
Q
G
R
F
T
G
E
V
E
V
V
-
D
G
G
F
R
V
N
G
K
E
V
K
S
F
S
E
P
D
A
S
K
L
P
W
K
D
L
N
I
D
V
V
L
E
C
T
G
F
Y
T
D
K
D
K
A
Q
A
H
I
E
A
G
A
K
K
V
L
I
S
A
P
A
T
G
D
L
K
T
I
V
F
N
T
N
H
Q
E
L
D
G
-
S
E
T
V
V
S
G
A
S
S
T
T
N
S
L
A
P
V
A
K
V
L
N
D
D
F
G
L
V
E
G
L
M
T
T
I
H
A
Y
T
G
D
Q
N
T
Q
D
A
P
H
R
K
G
D
K
R
R
A
R
A
A
A
E
N
I
I
P
N
S
T
G
A
A
K
A
I
G
K
V
I
P
E
I
D
G
K
L
D
G
G
A
Q
R
V
P
V
A
T
G
S
L
T
E
L
T
V
V
L
E
K
-
Q
D
V
T
V
E
Q
V
N
E
A
M
K
N
A
S
N
--------
E
---
S
F
G
Y
T
E
D
E
I
V
S
S
D
V
V
G
M
T
Y
G
S
L
F
D
A
T
Q
T
R
V
M
S
V
G
D
R
Q
L
V
K
V
A
A
W
Y
D
N
E
M
S
Y
T
A
Q
L
V
R
T
L
A
Y
L
A
E
L
--
7
PsiBlast_PDB
97.61
74%
-93
- C1 -
3LC1
3
G3P1_STAAR
P:
[1-336]
M
A
V
K
V
A
I
N
G
F
G
R
I
G
R
L
A
F
R
R
I
Q
E
--
V
E
--
G
--
L
E
V
V
A
V
N
D
L
T
-
D
D
D
M
L
A
H
L
L
K
Y
D
T
M
Q
G
R
F
T
G
E
V
E
V
V
-
D
G
G
F
R
V
N
G
K
E
V
K
S
F
S
E
P
D
A
S
K
L
P
W
K
D
L
N
I
D
V
V
L
E
C
T
G
F
Y
T
D
K
D
K
A
Q
A
H
I
E
A
G
A
K
K
V
L
I
S
A
P
A
T
G
D
L
K
T
I
V
F
N
T
N
H
Q
E
L
D
G
-
S
E
T
V
V
S
G
A
S
C
T
T
N
S
L
A
P
V
A
K
V
L
N
D
D
F
G
L
V
E
G
L
M
T
T
I
N
A
Y
T
G
D
Q
N
T
Q
D
A
P
H
R
K
G
D
K
R
R
A
R
A
A
A
E
N
I
I
P
N
S
T
G
A
A
K
A
I
G
K
V
I
P
E
I
D
G
K
L
D
G
G
A
Q
R
V
P
V
A
T
G
S
L
T
E
L
T
V
V
L
E
K
-
Q
D
V
T
V
E
Q
V
N
E
A
M
K
N
A
S
N
--------
E
---
S
F
G
Y
T
E
D
E
I
V
S
S
D
V
V
G
M
T
Y
G
S
L
F
D
A
T
Q
T
R
V
M
S
V
G
D
R
Q
L
V
K
V
A
A
W
Y
D
N
E
M
S
Y
T
A
Q
L
V
R
T
L
A
Y
L
A
E
L
S
K
4
PsiBlast_PDB
97.61
74%
-94
- C1 -
3LVF
2
G3P1_STAAR
P:
[3-338]
M
A
V
K
V
A
I
N
G
F
G
R
I
G
R
L
A
F
R
R
I
Q
E
--
V
E
--
G
--
L
E
V
V
A
V
N
D
L
T
-
D
D
D
M
L
A
H
L
L
K
Y
D
T
M
Q
G
R
F
T
G
E
V
E
V
V
-
D
G
G
F
R
V
N
G
K
E
V
K
S
F
S
E
P
D
A
S
K
L
P
W
K
D
L
N
I
D
V
V
L
E
C
T
G
F
Y
T
D
K
D
K
A
Q
A
H
I
E
A
G
A
K
K
V
L
I
S
A
P
A
T
G
D
L
K
T
I
V
F
N
T
N
H
Q
E
L
D
G
-
S
E
T
V
V
S
G
A
S
C
T
T
N
S
L
A
P
V
A
K
V
L
N
D
D
F
G
L
V
E
G
L
M
T
T
I
H
A
Y
T
G
D
Q
N
T
Q
D
A
P
H
R
K
G
D
K
R
R
A
R
A
A
A
E
N
I
I
P
N
S
T
G
A
A
K
A
I
G
K
V
I
P
E
I
D
G
K
L
D
G
G
A
Q
R
V
P
V
A
T
G
S
L
T
E
L
T
V
V
L
E
K
-
Q
D
V
T
V
E
Q
V
N
E
A
M
K
N
A
S
N
--------
E
---
S
F
G
Y
T
E
D
E
I
V
S
S
D
V
V
G
M
T
Y
G
S
L
F
D
A
T
Q
T
R
V
M
S
V
G
D
R
Q
L
V
K
V
A
A
W
Y
D
N
E
M
S
Y
T
A
Q
L
V
R
T
L
A
Y
L
A
E
L
S
K
46
PsiBlast_CBE
97.52
74%
-95
- C1 -
3HQ4
2
G3P1_STAAR
P:
[1-334]
M
A
V
K
V
A
I
N
G
F
G
R
I
G
R
L
A
F
R
R
I
Q
E
--
V
E
--
G
--
L
E
V
V
A
V
N
D
L
T
-
D
D
D
M
L
A
H
L
L
K
Y
D
T
M
Q
G
R
F
T
G
E
V
E
V
V
-
D
G
G
F
R
V
N
G
K
E
V
K
S
F
S
E
P
D
A
S
K
L
P
W
K
D
L
N
I
D
V
V
L
E
C
T
G
F
Y
T
D
K
D
K
A
Q
A
H
I
E
A
G
A
K
K
V
L
I
S
A
P
A
T
G
D
L
K
T
I
V
F
N
T
N
H
Q
E
L
D
G
-
S
E
T
V
V
S
G
A
S
S
T
T
N
S
L
A
P
V
A
K
V
L
N
D
D
F
G
L
V
E
G
L
M
T
T
I
H
A
Y
T
G
D
Q
N
T
Q
D
A
P
H
R
K
G
D
K
R
R
A
R
A
A
A
E
N
I
I
P
N
S
T
G
A
A
K
A
I
G
K
V
I
P
E
I
D
G
K
L
D
G
G
A
Q
R
V
P
V
A
T
G
S
L
T
E
L
T
V
V
L
E
K
-
Q
D
V
T
V
E
Q
V
N
E
A
M
K
N
A
S
N
--------
E
---
S
F
G
Y
T
E
D
E
I
V
S
S
D
V
V
G
M
T
Y
G
S
L
F
D
A
T
Q
T
R
V
M
S
V
G
D
R
Q
L
V
K
V
A
A
W
Y
D
N
E
M
S
Y
T
A
Q
L
V
R
T
L
A
Y
L
A
E
L
--
44
PsiBlast_CBE
97.33
74%
-96
- C1 -
3KV3
3
G3P1_STAAR
P:
[1-334]
M
A
V
K
V
A
I
N
G
F
G
R
I
G
R
L
A
F
R
R
I
Q
E
--
V
E
--
G
--
L
E
V
V
A
V
N
D
L
T
-
D
D
D
M
L
A
H
L
L
K
Y
D
T
M
Q
G
R
F
T
G
E
V
E
V
V
-
D
G
G
F
R
V
N
G
K
E
V
K
S
F
S
E
P
D
A
S
K
L
P
W
K
D
L
N
I
D
V
V
L
E
C
T
G
F
Y
T
D
K
D
K
A
Q
A
H
I
E
A
G
A
K
K
V
L
I
S
A
P
A
T
G
D
L
K
T
I
V
F
N
T
N
H
Q
E
L
D
G
-
S
E
T
V
V
S
G
A
S
S
T
T
N
S
L
A
P
V
A
K
V
L
N
D
D
F
G
L
V
E
G
L
M
T
T
I
H
A
Y
T
G
D
Q
N
T
Q
D
A
P
H
R
K
G
D
K
R
R
A
R
A
A
A
E
N
I
I
P
N
S
T
G
A
A
K
A
I
G
K
V
I
P
E
I
D
G
K
L
D
G
G
A
Q
R
V
P
V
A
T
G
S
L
T
E
L
T
V
V
L
E
K
-
Q
D
V
T
V
E
Q
V
N
E
A
M
K
N
A
S
N
--------
E
---
S
F
G
Y
T
E
D
E
I
V
S
S
D
V
V
G
M
T
Y
G
S
L
F
D
A
T
Q
T
R
V
M
S
V
G
D
R
Q
L
V
K
V
A
A
W
Y
D
N
E
M
S
Y
T
A
Q
L
V
R
T
L
A
Y
L
A
E
L
--
37
PsiBlast_CBE
97.33
74%
-95
- C1 -
3LVF
2
G3P1_STAAR
O:
[4-337]
-
A
V
K
V
A
I
N
G
F
G
R
I
G
R
L
A
F
R
R
I
Q
E
--
V
E
--
G
--
L
E
V
V
A
V
N
D
L
T
-
D
D
D
M
L
A
H
L
L
K
Y
D
T
M
Q
G
R
F
T
G
E
V
E
V
V
-
D
G
G
F
R
V
N
G
K
E
V
K
S
F
S
E
P
D
A
S
K
L
P
W
K
D
L
N
I
D
V
V
L
E
C
T
G
F
Y
T
D
K
D
K
A
Q
A
H
I
E
A
G
A
K
K
V
L
I
S
A
P
A
T
G
D
L
K
T
I
V
F
N
T
N
H
Q
E
L
D
G
-
S
E
T
V
V
S
G
A
S
C
T
T
N
S
L
A
P
V
A
K
V
L
N
D
D
F
G
L
V
E
G
L
M
T
T
I
H
A
Y
T
G
D
Q
N
T
Q
D
A
P
H
R
K
G
D
K
R
R
A
R
A
A
A
E
N
I
I
P
N
S
T
G
A
A
K
A
I
G
K
V
I
P
E
I
D
G
K
L
D
G
G
A
Q
R
V
P
V
A
T
G
S
L
T
E
L
T
V
V
L
E
K
-
Q
D
V
T
V
E
Q
V
N
E
A
M
K
N
A
S
N
--------
E
---
S
F
G
Y
T
E
D
E
I
V
S
S
D
V
V
G
M
T
Y
G
S
L
F
D
A
T
Q
T
R
V
M
S
V
G
D
R
Q
L
V
K
V
A
A
W
Y
D
N
E
M
S
Y
T
A
Q
L
V
R
T
L
A
Y
L
A
E
L
S
-
43
PsiBlast_CBE
97.13
74%
-95
- C1 -
3KV3
3
G3P1_STAAR
Q:
[1-334]
M
A
V
K
V
A
I
N
G
F
G
R
I
G
R
L
A
F
R
R
I
Q
E
--
V
E
--
G
--
L
E
V
V
A
V
N
D
L
T
-
D
D
D
M
L
A
H
L
L
K
Y
D
T
M
Q
G
R
F
T
G
E
V
E
V
V
-
D
G
G
F
R
V
N
G
K
E
V
K
S
F
S
E
P
D
A
S
K
L
P
W
K
D
L
N
I
D
V
V
L
E
C
T
G
F
Y
T
D
K
D
K
A
Q
A
H
I
E
A
G
A
K
K
V
L
I
S
A
P
A
T
G
D
L
K
T
I
V
F
N
T
N
H
Q
E
L
D
G
-
S
E
T
V
V
S
G
A
S
S
T
T
N
S
L
A
P
V
A
K
V
L
N
D
D
F
G
L
V
E
G
L
M
T
T
I
H
A
Y
T
G
D
Q
N
T
Q
D
A
P
H
R
K
G
D
K
R
R
A
R
A
A
A
E
N
I
I
P
N
S
T
G
A
A
K
A
I
G
K
V
I
P
E
I
D
G
K
L
D
G
G
A
Q
R
V
P
V
A
T
G
S
L
T
E
L
T
V
V
L
E
K
-
Q
D
V
T
V
E
Q
V
N
E
A
M
K
N
A
S
N
--------
E
---
S
F
G
Y
T
E
D
E
I
V
S
S
D
V
V
G
M
T
Y
G
S
L
F
D
A
T
Q
T
R
V
M
S
V
G
D
R
Q
L
V
K
V
A
A
W
Y
D
N
E
M
S
Y
T
A
Q
L
V
R
T
L
A
Y
L
A
E
L
--
51
PsiBlast_CBE
97.09
74%
-95
- C1 -
3K9Q
3
G3P1_STAAR
R:
[1-335]
M
A
V
K
V
A
I
N
G
F
G
R
I
G
R
L
A
F
R
R
I
Q
E
--
V
E
--
G
--
L
E
V
V
A
V
N
D
L
T
-
D
D
D
M
L
A
H
L
L
K
Y
D
T
M
Q
G
R
F
T
G
E
V
E
V
V
-
D
G
G
F
R
V
N
G
K
E
V
K
S
F
S
E
P
D
A
S
K
L
P
W
K
D
L
N
I
D
V
V
L
E
C
T
G
F
Y
T
D
K
D
K
A
Q
A
H
I
E
A
G
A
K
K
V
L
I
S
A
P
A
T
G
D
L
K
T
I
V
F
N
T
N
H
Q
E
L
D
G
-
S
E
T
V
V
S
G
A
S
G
T
T
N
S
L
A
P
V
A
K
V
L
N
D
D
F
G
L
V
E
G
L
M
T
T
I
H
A
Y
T
G
D
Q
N
T
Q
D
A
P
H
R
K
G
D
K
R
R
A
R
A
A
A
E
N
I
I
P
N
S
T
G
A
A
K
A
I
G
K
V
I
P
E
I
D
G
K
L
D
G
G
A
Q
R
V
P
V
A
T
G
S
L
T
E
L
T
V
V
L
E
K
-
Q
D
V
T
V
E
Q
V
N
E
A
M
K
N
A
S
N
--------
E
---
S
F
G
Y
T
E
D
E
I
V
S
S
D
V
V
G
M
T
Y
G
S
L
F
D
A
T
Q
T
R
V
M
S
V
G
D
R
Q
L
V
K
V
A
A
W
Y
D
N
E
M
S
Y
T
A
Q
L
V
R
T
L
A
Y
L
A
E
L
S
-
21
PsiBlast_CBE
97.05
74%
-93
- C1 -
3LC2
3
G3P1_STAAR
R:
[1-334]
M
A
V
K
V
A
I
N
G
F
G
R
I
G
R
L
A
F
R
R
I
Q
E
--
V
E
--
G
--
L
E
V
V
A
V
N
D
L
T
-
D
D
D
M
L
A
H
L
L
K
Y
D
T
M
Q
G
R
F
T
G
E
V
E
V
V
-
D
G
G
F
R
V
N
G
K
E
V
K
S
F
S
E
P
D
A
S
K
L
P
W
K
D
L
N
I
D
V
V
L
E
C
T
G
F
Y
T
D
K
D
K
A
Q
A
H
I
E
A
G
A
K
K
V
L
I
S
A
P
A
T
G
D
L
K
T
I
V
F
N
T
N
H
Q
E
L
D
G
-
S
E
T
V
V
S
G
A
S
C
T
T
N
S
L
A
P
V
A
K
V
L
N
D
D
F
G
L
V
E
G
L
M
T
T
I
H
A
Y
T
G
D
Q
N
T
Q
D
A
P
H
R
K
G
D
K
R
R
A
R
A
A
A
E
N
I
I
P
N
S
T
G
A
A
K
A
I
G
K
V
I
P
E
I
D
G
K
L
D
G
G
A
Q
R
V
P
V
A
T
G
S
L
T
E
L
T
V
V
L
E
K
-
Q
D
V
T
V
E
Q
V
N
E
A
M
K
N
A
S
N
--------
E
---
S
F
G
Y
T
E
D
E
I
V
S
S
D
V
V
G
M
T
Y
G
S
L
F
D
A
T
Q
T
R
V
M
S
V
G
D
R
Q
L
V
K
V
A
A
W
Y
D
N
E
M
S
Y
T
A
Q
L
V
R
T
L
A
Y
L
A
E
L
--
56
PsiBlast_CBE
96.92
73%
-94
- C1 -
3KSZ
3
G3P1_STAAR
P:
[2-335]
-
A
V
K
V
A
I
N
G
F
G
R
I
G
R
L
A
F
R
R
I
Q
E
--
V
E
--
G
--
L
E
V
V
A
V
N
D
L
T
-
D
D
D
M
L
A
H
L
L
K
Y
D
T
M
Q
G
R
F
T
G
E
V
E
V
V
-
D
G
G
F
R
V
N
G
K
E
V
K
S
F
S
E
P
D
A
S
K
L
P
W
K
D
L
N
I
D
V
V
L
E
C
T
G
F
Y
T
D
K
D
K
A
Q
A
H
I
E
A
G
A
K
K
V
L
I
S
A
P
A
T
G
D
L
K
T
I
V
F
N
T
N
H
Q
E
L
D
G
-
S
E
T
V
V
S
G
A
S
S
T
T
N
S
L
A
P
V
A
K
V
L
N
D
D
F
G
L
V
E
G
L
M
T
T
I
N
A
Y
T
G
D
Q
N
T
Q
D
A
P
H
R
K
G
D
K
R
R
A
R
A
A
A
E
N
I
I
P
N
S
T
G
A
A
K
A
I
G
K
V
I
P
E
I
D
G
K
L
D
G
G
A
Q
R
V
P
V
A
T
G
S
L
T
E
L
T
V
V
L
E
K
-
Q
D
V
T
V
E
Q
V
N
E
A
M
K
N
A
S
N
--------
E
---
S
F
G
Y
T
E
D
E
I
V
S
S
D
V
V
G
M
T
Y
G
S
L
F
D
A
T
Q
T
R
V
M
S
V
G
D
R
Q
L
V
K
V
A
A
W
Y
D
N
E
M
S
Y
T
A
Q
L
V
R
T
L
A
Y
L
A
E
L
S
-
52
PsiBlast_CBE
96.87
74%
-95
- C1 -
3K9Q
3
G3P1_STAAR
P:
[1-335]
M
A
V
K
V
A
I
N
G
F
G
R
I
G
R
L
A
F
R
R
I
Q
E
--
V
E
--
G
--
L
E
V
V
A
V
N
D
L
T
-
D
D
D
M
L
A
H
L
L
K
Y
D
T
M
Q
G
R
F
T
G
E
V
E
V
V
-
D
G
G
F
R
V
N
G
K
E
V
K
S
F
S
E
P
D
A
S
K
L
P
W
K
D
L
N
I
D
V
V
L
E
C
T
G
F
Y
T
D
K
D
K
A
Q
A
H
I
E
A
G
A
K
K
V
L
I
S
A
P
A
T
G
D
L
K
T
I
V
F
N
T
N
H
Q
E
L
D
G
-
S
E
T
V
V
S
G
A
S
G
T
T
N
S
L
A
P
V
A
K
V
L
N
D
D
F
G
L
V
E
G
L
M
T
T
I
H
A
Y
T
G
D
Q
N
T
Q
D
A
P
H
R
K
G
D
K
R
R
A
R
A
A
A
E
N
I
I
P
N
S
T
G
A
A
K
A
I
G
K
V
I
P
E
I
D
G
K
L
D
G
G
A
Q
R
V
P
V
A
T
G
S
L
T
E
L
T
V
V
L
E
K
-
Q
D
V
T
V
E
Q
V
N
E
A
M
K
N
A
S
N
--------
E
---
S
F
G
Y
T
E
D
E
I
V
S
S
D
V
V
G
M
T
Y
G
S
L
F
D
A
T
Q
T
R
V
M
S
V
G
D
R
Q
L
V
K
V
A
A
W
Y
D
N
E
M
S
Y
T
A
Q
L
V
R
T
L
A
Y
L
A
E
L
S
-
36
PsiBlast_CBE
96.67
74%
-95
- C1 -
3LVF
2
G3P1_STAAR
Q:
[4-337]
-
A
V
K
V
A
I
N
G
F
G
R
I
G
R
L
A
F
R
R
I
Q
E
--
V
E
--
G
--
L
E
V
V
A
V
N
D
L
T
-
D
D
D
M
L
A
H
L
L
K
Y
D
T
M
Q
G
R
F
T
G
E
V
E
V
V
-
D
G
G
F
R
V
N
G
K
E
V
K
S
F
S
E
P
D
A
S
K
L
P
W
K
D
L
N
I
D
V
V
L
E
C
T
G
F
Y
T
D
K
D
K
A
Q
A
H
I
E
A
G
A
K
K
V
L
I
S
A
P
A
T
G
D
L
K
T
I
V
F
N
T
N
H
Q
E
L
D
G
-
S
E
T
V
V
S
G
A
S
C
T
T
N
S
L
A
P
V
A
K
V
L
N
D
D
F
G
L
V
E
G
L
M
T
T
I
H
A
Y
T
G
D
Q
N
T
Q
D
A
P
H
R
K
G
D
K
R
R
A
R
A
A
A
E
N
I
I
P
N
S
T
G
A
A
K
A
I
G
K
V
I
P
E
I
D
G
K
L
D
G
G
A
Q
R
V
P
V
A
T
G
S
L
T
E
L
T
V
V
L
E
K
-
Q
D
V
T
V
E
Q
V
N
E
A
M
K
N
A
S
N
--------
E
---
S
F
G
Y
T
E
D
E
I
V
S
S
D
V
V
G
M
T
Y
G
S
L
F
D
A
T
Q
T
R
V
M
S
V
G
D
R
Q
L
V
K
V
A
A
W
Y
D
N
E
M
S
Y
T
A
Q
L
V
R
T
L
A
Y
L
A
E
L
S
-
31
PsiBlast_CBE
96.66
74%
-93
- C1 -
3VAZ
3
G3P1_STAAR
Q:
[10-342]
-
A
V
K
V
A
I
N
G
F
G
R
I
G
R
L
A
F
R
R
I
Q
E
--
V
E
--
G
--
L
E
V
V
A
V
N
D
L
T
-
D
D
D
M
L
A
H
L
L
K
Y
D
T
M
Q
G
R
F
T
G
E
V
E
V
V
-
D
G
G
F
R
V
N
G
K
E
V
K
S
F
S
E
P
D
A
S
K
L
P
W
K
D
L
N
I
D
V
V
L
E
C
T
G
F
Y
T
D
K
D
K
A
Q
A
H
I
E
A
G
A
K
K
V
L
I
S
A
P
A
T
G
D
L
K
T
I
V
F
N
T
N
H
Q
E
L
D
G
-
S
E
T
V
V
S
G
A
S
C
T
T
N
S
L
A
P
V
A
K
V
L
N
D
D
F
G
L
V
E
G
L
M
T
T
I
H
A
Y
T
G
D
Q
N
T
Q
D
A
P
H
R
K
G
D
K
R
R
A
R
A
A
A
E
N
I
I
P
N
S
T
G
A
A
K
A
I
G
K
V
I
P
E
I
D
G
K
L
D
G
G
A
Q
R
V
P
V
A
T
G
S
L
T
E
L
T
V
V
L
E
K
-
Q
D
V
T
V
E
Q
V
N
E
A
M
K
N
A
S
N
--------
E
---
S
F
G
Y
T
E
D
E
I
V
S
S
D
V
V
G
M
T
Y
G
S
L
F
D
A
T
Q
T
R
V
M
S
V
G
D
R
Q
L
V
K
V
A
A
W
Y
D
N
E
M
S
Y
T
A
Q
L
V
R
T
L
A
Y
L
A
E
L
--
28
PsiBlast_CBE
96.53
74%
-92
- C1 -
3K73
4
G3P1_STAAR
P:
[1-336]
M
A
V
K
V
A
I
N
G
F
G
R
I
G
R
L
A
F
R
R
I
Q
E
--
V
E
--
G
--
L
E
V
V
A
V
N
D
L
T
-
D
D
D
M
L
A
H
L
L
K
Y
D
T
M
Q
G
R
F
T
G
E
V
E
V
V
-
D
G
G
F
R
V
N
G
K
E
V
K
S
F
S
E
P
D
A
S
K
L
P
W
K
D
L
N
I
D
V
V
L
E
C
T
G
F
Y
T
D
K
D
K
A
Q
A
H
I
E
A
G
A
K
K
V
L
I
S
A
P
A
T
G
D
L
K
T
I
V
F
N
T
N
H
Q
E
L
D
G
-
S
E
T
V
V
S
G
A
S
C
T
T
N
S
L
A
P
V
A
K
V
L
N
D
D
F
G
L
V
E
G
L
M
T
T
I
H
A
Y
T
G
D
Q
N
T
Q
D
A
P
H
R
K
G
D
K
R
R
A
R
A
A
A
E
N
I
I
P
N
S
T
G
A
A
K
A
I
G
K
V
I
P
E
I
D
G
K
L
D
G
G
A
Q
R
V
P
V
A
T
G
S
L
T
E
L
T
V
V
L
E
K
-
Q
D
V
T
V
E
Q
V
N
E
A
M
K
N
A
S
N
--------
E
---
S
F
G
Y
T
E
D
E
I
V
S
S
D
V
V
G
M
T
Y
G
S
L
F
D
A
T
Q
T
R
V
M
S
V
G
D
R
Q
L
V
K
V
A
A
W
Y
D
N
E
M
S
Y
T
A
Q
L
V
R
T
L
A
Y
L
A
E
L
S
K
2
PsiBlast_PDB
96.53
74%
-93
- C1 -
3L6O
1
G3P1_STAAR
Q:
[1-334]
M
A
V
K
V
A
I
N
G
F
G
R
I
G
R
L
A
F
R
R
I
Q
E
--
V
E
--
G
--
L
E
V
V
A
V
N
D
L
T
-
D
D
D
M
L
A
H
L
L
K
Y
D
T
M
Q
G
R
F
T
G
E
V
E
V
V
-
D
G
G
F
R
V
N
G
K
E
V
K
S
F
S
E
P
D
A
S
K
L
P
W
K
D
L
N
I
D
V
V
L
E
C
T
G
F
Y
T
D
K
D
K
A
Q
A
H
I
E
A
G
A
K
K
V
L
I
S
A
P
A
T
G
D
L
K
T
I
V
F
N
T
N
H
Q
E
L
D
G
-
S
E
T
V
V
S
G
A
S
C
T
T
N
S
L
A
P
V
A
K
V
L
N
D
D
F
G
L
V
E
G
L
M
T
T
I
H
A
Y
T
G
D
Q
N
T
Q
D
A
P
H
R
K
G
D
K
R
R
A
R
A
A
A
E
N
I
I
P
N
S
T
G
A
A
K
A
I
G
K
V
I
P
E
I
D
G
K
L
D
G
G
A
Q
R
V
P
V
A
T
G
S
L
T
E
L
T
V
V
L
E
K
-
Q
D
V
T
V
E
Q
V
N
E
A
M
K
N
A
S
N
--------
E
---
S
F
G
Y
T
E
D
E
I
V
S
S
D
V
V
G
M
T
Y
G
S
L
F
D
A
T
Q
T
R
V
M
S
V
G
D
R
Q
L
V
K
V
A
A
W
Y
D
N
E
M
S
Y
T
A
Q
L
V
R
T
L
A
Y
L
A
E
L
--
53
PsiBlast_CBE
96.52
74%
-95
- C1 -
3K9Q
4
G3P1_STAAR
O:
[1-335]
M
A
V
K
V
A
I
N
G
F
G
R
I
G
R
L
A
F
R
R
I
Q
E
--
V
E
--
G
--
L
E
V
V
A
V
N
D
L
T
-
D
D
D
M
L
A
H
L
L
K
Y
D
T
M
Q
G
R
F
T
G
E
V
E
V
V
-
D
G
G
F
R
V
N
G
K
E
V
K
S
F
S
E
P
D
A
S
K
L
P
W
K
D
L
N
I
D
V
V
L
E
C
T
G
F
Y
T
D
K
D
K
A
Q
A
H
I
E
A
G
A
K
K
V
L
I
S
A
P
A
T
G
D
L
K
T
I
V
F
N
T
N
H
Q
E
L
D
G
-
S
E
T
V
V
S
G
A
S
G
T
T
N
S
L
A
P
V
A
K
V
L
N
D
D
F
G
L
V
E
G
L
M
T
T
I
H
A
Y
T
G
D
Q
N
T
Q
D
A
P
H
R
K
G
D
K
R
R
A
R
A
A
A
E
N
I
I
P
N
S
T
G
A
A
K
A
I
G
K
V
I
P
E
I
D
G
K
L
D
G
G
A
Q
R
V
P
V
A
T
G
S
L
T
E
L
T
V
V
L
E
K
-
Q
D
V
T
V
E
Q
V
N
E
A
M
K
N
A
S
N
--------
E
---
S
F
G
Y
T
E
D
E
I
V
S
S
D
V
V
G
M
T
Y
G
S
L
F
D
A
T
Q
T
R
V
M
S
V
G
D
R
Q
L
V
K
V
A
A
W
Y
D
N
E
M
S
Y
T
A
Q
L
V
R
T
L
A
Y
L
A
E
L
S
-
113
HHSearch
85.26
49%
-86
- C1 -
1RM4
3
G3PA_SPIOL
O:
[1-336]
-
K
L
K
V
A
I
N
G
F
G
R
I
G
R
N
F
L
R
C
W
H
G
--
R
K
DS
P
--
L
D
V
V
V
I
N
D
T
G
-
G
V
K
Q
A
S
H
L
L
K
Y
D
S
I
L
G
T
F
D
A
D
V
K
T
A
G
D
S
A
I
S
V
D
G
K
V
I
K
V
V
S
D
R
N
P
V
N
L
P
W
G
D
M
G
I
D
L
V
I
E
G
T
G
V
F
V
D
R
D
G
A
G
K
H
L
Q
A
G
A
K
K
V
L
I
T
A
P
G
K
G
D
I
P
T
Y
V
V
G
V
N
E
E
G
Y
T
H
-
A
D
T
I
I
S
N
A
S
C
T
T
N
C
L
A
P
F
V
K
V
L
D
Q
K
F
G
I
I
K
G
T
M
T
T
T
H
S
Y
T
G
D
Q
R
L
L
D
A
S
H
R
--
D
L
R
R
A
R
A
A
C
L
N
I
V
P
T
S
T
G
A
A
K
A
V
A
L
V
L
P
N
L
K
G
K
L
N
G
I
A
L
R
V
P
T
P
N
V
S
V
V
D
L
V
V
Q
V
S
K
-
K
-
T
F
A
E
E
V
N
A
A
F
R
E
S
A
D
N
-------
E
LKG
I
L
S
V
C
D
E
P
L
V
S
I
D
F
R
C
T
D
V
S
S
T
I
D
S
S
L
T
M
V
M
---
G
D
D
M
V
K
V
I
A
W
Y
D
N
E
W
G
Y
S
Q
R
V
V
D
L
A
D
I
V
A
N
K
W
Q
121
HHSearch
84.95
55%
-83
- C1 -
2EP7
1
G3P_AQUAE
A:
[3-340]
--
I
K
V
G
I
N
G
F
G
R
I
G
R
S
F
F
R
A
S
W
G
--
R
E
--
E
--
I
E
I
V
A
I
N
D
L
T
-
D
A
K
H
L
A
H
L
L
K
Y
D
S
V
H
G
I
F
K
G
S
V
E
A
K
-
D
D
S
I
V
V
D
G
K
E
I
K
V
F
A
Q
K
D
P
S
Q
I
P
W
G
D
L
G
V
D
V
V
I
E
A
T
G
V
F
R
D
R
E
N
A
S
K
H
L
Q
G
G
A
K
K
V
I
I
T
A
P
A
K
N
P
D
I
T
V
V
L
G
V
N
E
E
K
Y
N
P
K
E
H
N
I
I
S
N
A
S
C
T
T
N
C
L
A
P
C
V
K
V
L
N
E
A
F
G
V
E
K
G
Y
M
V
T
V
H
A
Y
T
N
D
Q
R
L
L
D
L
P
H
K
--
D
F
R
R
A
R
A
A
A
I
N
I
V
P
T
T
T
G
A
A
K
A
I
G
E
V
I
P
E
L
K
G
K
L
D
G
T
A
R
R
V
P
V
P
D
G
S
L
I
D
L
T
V
V
V
N
K
-
A
P
S
S
V
E
E
V
N
E
K
F
R
E
A
A
Q
K
Y
R
E
SGKV
Y
LKE
I
L
Q
Y
C
E
D
P
I
V
S
T
D
I
V
G
N
P
H
S
A
I
F
D
A
P
L
T
Q
V
I
----
D
N
L
V
H
I
A
A
W
Y
D
N
E
W
G
Y
S
C
R
L
R
D
L
V
I
Y
L
A
E
R
--
116
HHSearch
84.38
56%
-86
- C1 -
1HDG
3
G3P_THEMA
O:
[1-332]
--
A
R
V
A
I
N
G
F
G
R
I
G
R
L
V
Y
R
I
I
Y
E
RK
N
P
--
D
--
I
E
V
V
A
I
N
D
L
T
-
D
T
K
T
L
A
H
L
L
K
Y
D
S
V
H
K
K
F
P
G
K
V
E
Y
T
-
E
N
S
L
I
V
D
G
K
E
I
K
V
F
A
E
P
D
P
S
K
L
P
W
K
D
L
G
V
D
F
V
I
E
S
T
G
V
F
R
N
R
E
K
A
E
L
H
L
Q
A
G
A
K
K
V
I
I
T
A
P
A
K
G
E
D
I
T
V
V
I
G
C
N
E
D
Q
L
K
P
-
E
H
T
I
I
S
C
A
S
C
T
T
N
S
I
A
P
I
V
K
V
L
H
E
K
F
G
I
V
S
G
M
L
T
T
V
H
S
Y
T
N
D
Q
R
V
L
D
L
P
H
K
--
D
L
R
R
A
R
A
A
A
V
N
I
I
P
T
T
T
G
A
A
K
A
V
A
L
V
V
P
E
V
K
G
K
L
D
G
M
A
I
R
V
P
T
P
D
G
S
I
T
D
L
T
V
L
V
E
K
-
E
-
T
T
V
E
E
V
N
A
V
M
K
E
A
T
E
G
-------
R
LKG
I
I
G
Y
N
D
E
P
I
V
S
S
D
I
I
G
T
T
F
S
G
I
F
D
A
T
I
T
N
V
I
---
G
G
K
L
V
K
V
A
S
W
Y
D
N
E
Y
G
Y
S
N
R
V
V
D
T
L
E
L
L
L
K
M
--
122
HHSearch
83.79
48%
-89
- C1 -
3PYM
3
G3P3_YEAST
A:
[1-331]
-
M
V
R
V
A
I
N
G
F
G
R
I
G
R
L
V
M
R
I
A
L
S
--
R
P
--
N
--
V
E
V
V
A
L
N
D
P
F
I
T
N
D
Y
A
A
Y
M
F
K
Y
D
S
T
H
G
R
Y
A
G
E
V
S
H
D
-
D
K
H
I
I
V
D
G
K
K
I
A
T
Y
Q
E
R
D
P
A
N
L
P
W
G
S
S
N
V
D
I
A
I
D
S
T
G
V
F
K
E
L
D
T
A
Q
K
H
I
D
A
G
A
K
K
V
V
I
T
A
P
S
S
T
-
A
P
M
F
V
M
G
V
N
E
E
K
Y
T
S
-
D
L
K
I
V
S
N
A
S
C
T
T
N
C
L
A
P
L
A
K
V
I
N
D
A
F
G
I
E
E
G
L
M
T
T
V
H
S
L
T
A
T
Q
K
T
V
D
G
P
S
H
K
-
D
W
R
G
G
R
T
A
S
G
N
I
I
P
S
S
T
G
A
A
K
A
V
G
K
V
L
P
E
L
Q
G
K
L
T
G
M
A
F
R
V
P
T
V
D
V
S
V
V
D
L
T
V
K
L
N
K
-
E
-
T
T
Y
D
E
I
K
K
V
V
K
A
A
A
E
G
-------
K
LKG
V
L
G
Y
T
E
D
A
V
V
S
S
D
F
L
G
D
S
H
S
S
I
F
D
A
S
A
G
I
Q
L
---
S
P
K
F
V
K
L
V
S
W
Y
D
N
E
Y
G
Y
S
T
R
V
V
D
L
V
E
H
V
A
K
---
17
PsiBlast_PDB
82.77
54%
-85
- C1 -
1HDG
3
G3P_THEMA
O:
[2-332]
---
R
V
A
I
N
G
F
G
R
I
G
R
L
V
Y
R
I
I
Y
E
--
R
K
--
N
PD
I
E
V
V
A
I
N
D
L
T
-
D
T
K
T
L
A
H
L
L
K
Y
D
S
V
H
K
K
F
P
G
K
V
E
Y
T
-
E
N
S
L
I
V
D
G
K
E
I
K
V
F
A
E
P
D
P
S
K
L
P
W
K
D
L
G
V
D
F
V
I
E
S
T
G
V
F
R
N
R
E
K
A
E
L
H
L
Q
A
G
A
K
K
V
I
I
T
A
P
A
K
G
E
D
I
T
V
V
I
G
C
N
E
D
Q
L
K
P
-
E
H
T
I
I
S
C
A
S
C
T
T
N
S
I
A
P
I
V
K
V
L
H
E
K
F
G
I
V
S
G
M
L
T
T
V
H
S
Y
T
N
D
Q
R
V
L
D
L
P
H
K
--
D
L
R
R
A
R
A
A
A
V
N
I
I
P
T
T
T
G
A
A
K
A
V
A
L
V
V
P
E
V
K
G
K
L
D
G
M
A
I
R
V
P
T
P
D
G
S
I
T
D
L
T
V
L
V
E
K
-
E
-
T
T
V
E
E
V
N
A
V
M
K
E
A
T
E
G
-------
R
LKG
I
I
G
Y
N
D
E
P
I
V
S
S
D
I
I
G
T
T
F
S
G
I
F
D
A
T
I
T
N
V
I
---
G
G
K
L
V
K
V
A
S
W
Y
D
N
E
Y
G
Y
S
N
R
V
V
D
T
L
E
L
L
L
K
M
--
117
HHSearch
82.55
49%
-89
- C1 -
3CPS
1
?
A:
[18-353]
--
G
T
L
G
I
N
G
F
G
R
I
G
R
L
V
L
R
A
C
M
E
--
R
N
--
D
--
I
T
V
V
A
I
N
D
P
F
M
D
V
E
Y
M
A
Y
L
L
K
Y
D
S
V
H
G
N
F
N
G
T
V
E
V
S
-
G
-
D
L
C
I
N
G
K
V
V
K
V
F
Q
A
K
D
P
A
E
I
P
W
G
A
S
G
A
Q
I
V
C
E
S
T
G
V
F
T
T
E
E
K
A
S
L
H
L
K
G
G
A
K
K
V
I
I
S
A
P
P
K
D
N
V
P
M
Y
V
M
G
V
N
N
T
E
Y
D
P
S
K
F
N
V
I
S
N
A
S
C
T
T
N
C
L
A
P
L
A
K
I
I
N
D
K
F
G
I
V
E
G
L
M
T
T
V
H
S
L
T
A
N
Q
L
T
V
D
G
P
S
K
G
-
D
W
R
A
G
R
C
A
G
N
N
I
I
P
A
S
T
G
A
A
K
A
V
G
K
V
I
P
A
L
N
G
K
L
T
G
M
A
I
R
V
P
T
P
D
V
S
V
V
D
L
T
C
K
L
A
K
-
P
-
A
S
I
E
E
I
Y
Q
A
V
K
E
A
S
N
G
-------
P
MKG
I
M
G
Y
T
S
D
D
V
V
S
T
D
F
I
G
C
K
Y
S
S
I
F
D
K
N
A
C
I
A
L
---
N
D
S
F
V
K
L
I
S
W
Y
D
N
E
S
G
Y
S
N
R
L
V
D
L
A
V
Y
V
A
S
R
G
-
72
PsiBlast_CBE
81.91
54%
-85
- C1 -
1HDG
3
G3P_THEMA
Q:
[2-332]
---
R
V
A
I
N
G
F
G
R
I
G
R
L
V
Y
R
I
I
Y
E
--
R
K
--
N
PD
I
E
V
V
A
I
N
D
L
T
-
D
T
K
T
L
A
H
L
L
K
Y
D
S
V
H
K
K
F
P
G
K
V
E
Y
T
-
E
N
S
L
I
V
D
G
K
E
I
K
V
F
A
E
P
D
P
S
K
L
P
W
K
D
L
G
V
D
F
V
I
E
S
T
G
V
F
R
N
R
E
K
A
E
L
H
L
Q
A
G
A
K
K
V
I
I
T
A
P
A
K
G
E
D
I
T
V
V
I
G
C
N
E
D
Q
L
K
P
-
E
H
T
I
I
S
C
A
S
C
T
T
N
S
I
A
P
I
V
K
V
L
H
E
K
F
G
I
V
S
G
M
L
T
T
V
H
S
Y
T
N
D
Q
R
V
L
D
L
P
H
K
--
D
L
R
R
A
R
A
A
A
V
N
I
I
P
T
T
T
G
A
A
K
A
V
A
L
V
V
P
E
V
K
G
K
L
D
G
M
A
I
R
V
P
T
P
D
G
S
I
T
D
L
T
V
L
V
E
K
-
E
-
T
T
V
E
E
V
N
A
V
M
K
E
A
T
E
G
-------
R
LKG
I
I
G
Y
N
D
E
P
I
V
S
S
D
I
I
G
T
T
F
S
G
I
F
D
A
T
I
T
N
V
I
---
G
G
K
L
V
K
V
A
S
W
Y
D
N
E
Y
G
Y
S
N
R
V
V
D
T
L
E
L
L
L
K
M
--
124
HHSearch
79.00
43%
-84
- C1 -
3H9E
10
G3PT_HUMAN
O:
[6-339]
R
E
L
T
V
G
I
N
G
F
G
R
I
G
R
L
V
L
R
A
C
M
E
--
K
---
G
--
V
K
V
V
A
V
N
D
P
F
I
D
P
E
Y
M
V
Y
M
F
K
Y
D
S
T
H
G
R
Y
K
G
S
V
E
F
R
-
N
G
Q
L
V
V
D
N
H
E
I
S
V
Y
Q
C
K
E
P
K
Q
I
P
W
R
A
V
G
S
P
Y
V
V
E
S
T
G
V
Y
L
S
I
Q
A
A
S
D
H
I
S
A
G
A
Q
R
V
V
I
S
A
P
S
P
D
-
A
P
M
F
V
M
G
V
N
E
N
D
Y
N
P
G
S
M
N
I
V
S
N
A
S
C
T
T
N
C
L
A
P
L
A
K
V
I
H
E
R
F
G
I
V
E
G
L
M
T
T
V
H
S
Y
T
A
T
Q
K
T
V
D
G
P
S
R
K
-
A
W
R
D
G
R
G
A
H
Q
N
I
I
P
A
S
T
G
A
A
K
A
V
T
K
V
I
P
E
L
K
G
K
L
T
G
M
A
F
R
V
P
T
P
D
V
S
V
V
D
L
T
C
R
L
A
Q
-
P
-
A
P
Y
S
A
I
K
E
A
V
K
A
A
A
K
G
-------
P
MAG
I
L
A
Y
T
E
D
E
V
V
S
T
D
F
L
G
D
T
H
S
S
I
F
D
A
K
A
G
I
A
L
---
N
D
N
F
V
K
L
I
S
W
Y
D
N
E
Y
G
Y
S
H
R
V
V
D
L
L
R
Y
M
F
S
R
D
-