@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : gbs0117: (2015-11-28 )
MSNIVIIGSISMDLVMETNRIAKEGETVFGQRFSMVPGGKGANQAVAIGRLSQDRDNITILGAIGEDSFGPILLDNLNKNHVTTDFVGTIPSSSGVAQITLYNNDNRIIYCPGANGKVDTKKWSQEWSIIKEADLVVLQNEIPHQANMKIANFCKEHSIKLLYNPAPSRKTDIEMLDKVDYFTPNEHECQELFPNQKLEDILATYPEKLIVTLGTKGAIYSDGKESHLIPALETKAVDTTGAGDTFNGAFGYAISKKFKIANALRFATLAAHLSVQKFGAQGGMPTIKEMEDNQHYEKDWHIK
Atome Classification :
(25 SA)
.........10........20........30.-.......40........50........60........70........80......-..90-.-.-......100..-.-.....110.......120.......130.......140.......150.......160......-.170........180.......190.---------....---------..200.......210-------.........220...--...--.230.......240.......250...--.--.-..260.......270.......280.......290.......300.
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MS
N
I
V
I
I
GSI
S
M
D
L
V
ME
T
N
R
IAKEG
E
T
V
F
G
Q
R
-FSMVPGGKGAN
Q
A
V
A
IGRLSQDRD
N
I
T
I
L
G
AIGEDSFG
P
I
L
L
DNLNKNHVTTD
F
V
-GTIP-S-S-S
G
V
A
Q
I
T
L
-YN-N-D
N
R
I
I
Y
CPGANGKV
D
T
K
K
W
S
Q
E
W
S
I
IKEA
D
L
V
V
L
QNEIPHQAN
M
K
I
A
N
F
C
K
EH
S
I
K
L
L
YNPAPS-RK-
T
D
I
E
M
L
DKVDYFTP
N
E
H
E
C
Q
E
LF---------PN
Q
K
---------
L
E
D
I
L
A
TYP
E
K
L
I
---------
V
T
LGTKG
A
I
YSDGKE--SHL--IPALETKAVDTTGAGDTFNGAFG
Y
A
I
S
--
K
--
K
-
F
K
I
A
N
A
L
R
F
A
T
L
A
A
H
L
S
V
Q
K
FGAQGGMP
T
I
K
E
MEDNQHYEKDWHIK
4
PsiBlast_PDB
93.52
33%
-72
- C1 -
4XDA
4
?
A:
[4-302]
M
N
K
L
V
V
L
G
S
V
N
A
D
H
V
L
Q
V
P
S
F
P
R
P
G
E
T
L
H
G
R
N
-
Y
Q
V
I
P
G
G
K
G
A
N
Q
A
V
A
A
A
R
M
Q
A
D
---
V
G
F
I
A
C
V
G
D
D
S
F
G
I
N
I
R
E
S
F
K
L
D
G
I
N
T
A
G
V
-
K
L
Q
P
-
N
-
C
P
T
G
I
A
M
I
Q
V
-
S
D
-
S
G
E
N
S
I
C
I
S
A
E
A
N
A
K
L
T
A
A
A
I
E
P
D
L
A
A
I
R
D
A
R
Y
L
L
M
Q
L
E
T
P
L
D
G
I
L
K
A
A
Q
E
A
K
T
A
K
T
N
V
I
L
N
P
A
P
A
-
R
E
-
L
P
D
E
L
L
K
C
V
D
L
I
T
P
N
E
T
E
A
E
V
L
T
G
I
T
V
Y
D
D
S
S
A
Q
Q
A
---------
A
D
A
L
H
C
K
G
I
E
I
V
I
---------
I
T
L
G
S
K
G
V
W
L
S
Q
N
G
R
--
G
Q
R
--
I
P
G
F
V
V
K
A
T
D
T
T
A
A
G
D
T
F
N
G
A
L
V
T
G
L
L
--
Q
--
E
-
M
P
L
E
S
A
I
K
F
A
H
A
A
A
A
I
S
V
T
R
F
G
A
Q
T
S
I
P
T
R
A
E
V
E
A
F
L
A
E
H
S
-----
58
HHSearch
93.19
32%
-68
* C1 *
1RKD
4
RBSK_ECOLI
A:
[4-308]
A
G
S
L
V
V
L
G
S
I
N
A
D
H
I
L
N
L
Q
S
F
P
T
P
G
E
T
V
T
G
N
H
-
Y
Q
V
A
F
G
G
K
G
A
N
Q
A
V
A
A
G
R
S
G
-
A
--
N
I
A
F
I
A
C
T
G
D
D
S
I
G
E
S
V
R
Q
Q
L
A
T
D
N
I
D
I
T
P
V
-
S
V
I
K
G
E
-
S
-
T
G
V
A
L
I
F
V
N
G
E
-
G
-
E
N
V
I
G
I
H
A
G
A
N
A
A
L
S
P
A
L
V
E
A
Q
R
E
R
I
A
N
A
S
A
L
L
M
Q
L
E
S
P
L
E
S
V
M
A
A
A
K
I
A
H
Q
N
K
T
I
V
A
L
N
P
A
P
A
-
R
E
-
L
P
D
E
L
L
A
L
V
D
I
I
T
P
N
E
T
E
A
E
K
L
T
---------
G
I
R
V
EN
D
E
D
A
A
K
A
A
Q
V
L
H
E
K
G
I
R
T
V
L
---------
I
T
L
G
S
R
G
V
W
A
S
V
N
G
E
--
G
Q
R
--
V
P
G
F
R
V
Q
A
V
D
T
I
A
A
G
D
T
F
N
G
A
L
I
T
A
L
L
--
E
--
E
-
K
P
L
P
E
A
I
R
F
A
H
A
A
A
A
I
A
V
T
R
K
G
A
Q
P
S
V
P
W
R
E
E
I
D
A
F
L
D
R
Q
R
-----
23
PsiBlast_CBE
93.16
33%
-74
- C1 -
4XDA
3
?
B:
[4-302]
M
N
K
L
V
V
L
G
S
V
N
A
D
H
V
L
Q
V
P
S
F
P
R
P
G
E
T
L
H
G
R
N
-
Y
Q
V
I
P
G
G
K
G
A
N
Q
A
V
A
A
A
R
M
Q
A
D
---
V
G
F
I
A
C
V
G
D
D
S
F
G
I
N
I
R
E
S
F
K
L
D
G
I
N
T
A
G
V
-
K
L
Q
P
-
N
-
C
P
T
G
I
A
M
I
Q
V
-
S
D
-
S
G
E
N
S
I
C
I
S
A
E
A
N
A
K
L
T
A
A
A
I
E
P
D
L
A
A
I
R
D
A
R
Y
L
L
M
Q
L
E
T
P
L
D
G
I
L
K
A
A
Q
E
A
K
T
A
K
T
N
V
I
L
N
P
A
P
A
-
R
E
-
L
P
D
E
L
L
K
C
V
D
L
I
T
P
N
E
T
E
A
E
V
L
T
GITVYDDSS
A
Q
Q
A
---------
A
D
A
L
H
C
K
G
I
E
I
V
I
---------
I
T
L
G
S
K
G
V
W
L
S
Q
N
G
R
--
G
Q
R
--
I
P
G
F
V
V
K
A
T
D
T
T
A
A
G
D
T
F
N
G
A
L
V
T
G
L
L
--
Q
--
E
-
M
P
L
E
S
A
I
K
F
A
H
A
A
A
A
I
S
V
T
R
F
G
A
Q
T
S
I
P
T
R
A
E
V
E
A
F
L
A
E
H
S
-----
24
PsiBlast_CBE
92.92
33%
-68
- C1 -
4XCK
2
?
D:
[4-302]
M
N
K
L
V
V
L
G
S
V
N
A
D
H
V
L
Q
V
P
S
F
P
R
P
G
E
T
L
H
G
R
N
-
Y
Q
V
I
P
G
G
K
G
A
N
Q
A
V
A
A
A
R
M
Q
A
D
---
V
G
F
I
A
C
V
G
D
D
S
F
G
I
N
I
R
E
S
F
K
L
D
G
I
N
T
A
G
V
-
K
L
Q
P
-
N
-
C
P
T
G
I
A
M
I
Q
V
-
S
D
-
S
G
E
N
S
I
C
I
S
A
E
A
N
A
K
L
T
A
A
A
I
E
P
D
L
A
A
I
R
D
A
R
Y
L
L
M
Q
L
E
T
P
L
D
G
I
L
K
A
A
Q
E
A
K
T
A
K
T
N
V
I
L
N
P
A
P
A
-
R
E
-
L
P
D
E
L
L
K
C
V
D
L
I
T
P
N
E
T
E
A
E
V
L
T
GITVYDDSS
A
Q
Q
A
---------
A
D
A
L
H
C
K
G
I
E
I
V
I
---------
I
T
L
G
S
K
G
V
W
L
S
Q
N
G
R
--
G
Q
R
--
I
P
G
F
V
V
K
A
T
D
T
T
A
A
G
D
T
F
N
G
A
L
V
T
G
L
L
--
Q
--
E
-
M
P
L
E
S
A
I
K
F
A
H
A
A
A
A
I
S
V
T
R
F
G
A
Q
T
S
I
P
T
R
A
E
V
E
A
F
L
A
E
H
S
-----
26
PsiBlast_CBE
92.33
33%
-69
- C1 -
4XCK
3
?
B:
[4-302]
M
N
K
L
V
V
L
G
S
V
N
A
D
H
V
L
Q
V
P
S
F
P
R
P
G
E
T
L
H
G
R
N
-
Y
Q
V
I
P
G
G
K
G
A
N
Q
A
V
A
A
A
R
M
Q
A
D
---
V
G
F
I
A
C
V
G
D
D
S
F
G
I
N
I
R
E
S
F
K
L
D
G
I
N
T
A
G
V
-
K
L
Q
P
-
N
-
C
P
T
G
I
A
M
I
Q
V
-
S
D
-
S
G
E
N
S
I
C
I
S
A
E
A
N
A
K
L
T
A
A
A
I
E
P
D
L
A
A
I
R
D
A
R
Y
L
L
M
Q
L
E
T
P
L
D
G
I
L
K
A
A
Q
E
A
K
T
A
K
T
N
V
I
L
N
P
A
P
A
-
R
E
-
L
P
D
E
L
L
K
C
V
D
L
I
T
P
N
E
T
E
A
E
V
L
T
GITVYDDSS
A
Q
Q
A
---------
A
D
A
L
H
C
K
G
I
E
I
V
I
---------
I
T
L
G
S
K
G
V
W
L
S
Q
N
G
R
--
G
Q
R
--
I
P
G
F
V
V
K
A
T
D
T
T
A
A
G
D
T
F
N
G
A
L
V
T
G
L
L
--
Q
--
E
-
M
P
L
E
S
A
I
K
F
A
H
A
A
A
A
I
S
V
T
R
F
G
A
Q
T
S
I
P
T
R
A
E
V
E
A
F
L
A
E
H
S
-----
21
PsiBlast_CBE
92.27
33%
-73
- C1 -
4XDA
3
?
D:
[4-302]
M
N
K
L
V
V
L
G
S
V
N
A
D
H
V
L
Q
V
P
S
F
P
R
P
G
E
T
L
H
G
R
N
-
Y
Q
V
I
P
G
G
K
G
A
N
Q
A
V
A
A
A
R
M
Q
A
D
---
V
G
F
I
A
C
V
G
D
D
S
F
G
I
N
I
R
E
S
F
K
L
D
G
I
N
T
A
G
V
-
K
L
Q
P
-
N
-
C
P
T
G
I
A
M
I
Q
V
-
S
D
-
S
G
E
N
S
I
C
I
S
A
E
A
N
A
K
L
T
A
A
A
I
E
P
D
L
A
A
I
R
D
A
R
Y
L
L
M
Q
L
E
T
P
L
D
G
I
L
K
A
A
Q
E
A
K
T
A
K
T
N
V
I
L
N
P
A
P
A
-
R
E
-
L
P
D
E
L
L
K
C
V
D
L
I
T
P
N
E
T
E
A
E
V
L
T
GITVYDDSS
A
Q
Q
A
---------
A
D
A
L
H
C
K
G
I
E
I
V
I
---------
I
T
L
G
S
K
G
V
W
L
S
Q
N
G
R
--
G
Q
R
--
I
P
G
F
V
V
K
A
T
D
T
T
A
A
G
D
T
F
N
G
A
L
V
T
G
L
L
--
Q
--
E
-
M
P
L
E
S
A
I
K
F
A
H
A
A
A
A
I
S
V
T
R
F
G
A
Q
T
S
I
P
T
R
A
E
V
E
A
F
L
A
E
H
S
-----
22
PsiBlast_CBE
92.09
33%
-71
- C1 -
4XDA
3
?
C:
[4-302]
M
N
K
L
V
V
L
G
S
V
N
A
D
H
V
L
Q
V
P
S
F
P
R
P
G
E
T
L
H
G
R
N
-
Y
Q
V
I
P
G
G
K
G
A
N
Q
A
V
A
A
A
R
M
Q
A
D
---
V
G
F
I
A
C
V
G
D
D
S
F
G
I
N
I
R
E
S
F
K
L
D
G
I
N
T
A
G
V
-
K
L
Q
P
-
N
-
C
P
T
G
I
A
M
I
Q
V
-
S
D
-
S
G
E
N
S
I
C
I
S
A
E
A
N
A
K
L
T
A
A
A
I
E
P
D
L
A
A
I
R
D
A
R
Y
L
L
M
Q
L
E
T
P
L
D
G
I
L
K
A
A
Q
E
A
K
T
A
K
T
N
V
I
L
N
P
A
P
A
-
R
E
-
L
P
D
E
L
L
K
C
V
D
L
I
T
P
N
E
T
E
A
E
V
L
T
GITVYDDSS
A
Q
Q
A
---------
A
D
A
L
H
C
K
G
I
E
I
V
I
---------
I
T
L
G
S
K
G
V
W
L
S
Q
N
G
R
--
G
Q
R
--
I
P
G
F
V
V
K
A
T
D
T
T
A
A
G
D
T
F
N
G
A
L
V
T
G
L
L
--
Q
--
E
-
M
P
L
E
S
A
I
K
F
A
H
A
A
A
A
I
S
V
T
R
F
G
A
Q
T
S
I
P
T
R
A
E
V
E
A
F
L
A
E
H
S
-----
25
PsiBlast_CBE
91.92
33%
-73
- C1 -
4XCK
3
?
C:
[4-302]
M
N
K
L
V
V
L
G
S
V
N
A
D
H
V
L
Q
V
P
S
F
P
R
P
G
E
T
L
H
G
R
N
-
Y
Q
V
I
P
G
G
K
G
A
N
Q
A
V
A
A
A
R
M
Q
A
D
---
V
G
F
I
A
C
V
G
D
D
S
F
G
I
N
I
R
E
S
F
K
L
D
G
I
N
T
A
G
V
-
K
L
Q
P
-
N
-
C
P
T
G
I
A
M
I
Q
V
-
S
D
-
S
G
E
N
S
I
C
I
S
A
E
A
N
A
K
L
T
A
A
A
I
E
P
D
L
A
A
I
R
D
A
R
Y
L
L
M
Q
L
E
T
P
L
D
G
I
L
K
A
A
Q
E
A
K
T
A
K
T
N
V
I
L
N
P
A
P
A
-
R
E
-
L
P
D
E
L
L
K
C
V
D
L
I
T
P
N
E
T
E
A
E
V
L
T
GITVYDDSS
A
Q
Q
A
---------
A
D
A
L
H
C
K
G
I
E
I
V
I
---------
I
T
L
G
S
K
G
V
W
L
S
Q
N
G
R
--
G
Q
R
--
I
P
G
F
V
V
K
A
T
D
T
T
A
A
G
D
T
F
N
G
A
L
V
T
G
L
L
--
Q
--
E
-
M
P
L
E
S
A
I
K
F
A
H
A
A
A
A
I
S
V
T
R
F
G
A
Q
T
S
I
P
T
R
A
E
V
E
A
F
L
A
E
H
S
-----
3
PsiBlast_PDB
91.59
33%
-73
- C1 -
4XCK
4
?
A:
[4-302]
M
N
K
L
V
V
L
G
S
V
N
A
D
H
V
L
Q
V
P
S
F
P
R
P
G
E
T
L
H
G
R
N
-
Y
Q
V
I
P
G
G
K
G
A
N
Q
A
V
A
A
A
R
M
Q
A
D
---
V
G
F
I
A
C
V
G
D
D
S
F
G
I
N
I
R
E
S
F
K
L
D
G
I
N
T
A
G
V
-
K
L
Q
P
-
N
-
C
P
T
G
I
A
M
I
Q
V
-
S
D
-
S
G
E
N
S
I
C
I
S
A
E
A
N
A
K
L
T
A
A
A
I
E
P
D
L
A
A
I
R
D
A
R
Y
L
L
M
Q
L
E
T
P
L
D
G
I
L
K
A
A
Q
E
A
K
T
A
K
T
N
V
I
L
N
P
A
P
A
-
R
E
-
L
P
D
E
L
L
K
C
V
D
L
I
T
P
N
E
T
E
A
E
V
L
T
GITVYD
D
S
S
A
Q
Q
A
---------
A
D
A
L
H
C
K
G
I
E
I
V
I
---------
I
T
L
G
S
K
G
V
W
L
S
Q
N
G
R
--
G
Q
R
--
I
P
G
F
V
V
K
A
T
D
T
T
A
A
G
D
T
F
N
G
A
L
V
T
G
L
L
--
Q
--
E
-
M
P
L
E
S
A
I
K
F
A
H
A
A
A
A
I
S
V
T
R
F
G
A
Q
T
S
I
P
T
R
A
E
V
E
A
F
L
A
E
H
S
-----
11
PsiBlast_PDB
91.55
32%
-68
- C1 -
1RKD
4
RBSK_ECOLI
A:
[6-302]
--
S
L
V
V
L
G
S
I
N
A
D
H
I
L
N
L
Q
S
F
P
T
P
G
E
T
V
T
G
N
H
-
Y
Q
V
A
F
G
G
K
G
A
N
Q
A
V
A
A
G
R
S
G
A
---
N
I
A
F
I
A
C
T
G
D
D
S
I
G
E
S
V
R
Q
Q
L
A
T
D
N
I
D
I
T
P
V
-
S
V
I
K
-
G
E
S
-
T
G
V
A
L
I
F
V
-
N
G
E
G
-
E
N
V
I
G
I
H
A
G
A
N
A
A
L
S
P
A
L
V
E
A
Q
R
E
R
I
A
N
A
S
A
L
L
M
Q
L
E
S
P
L
E
S
V
M
A
A
A
K
I
A
H
Q
N
K
T
I
V
A
L
N
P
A
P
A
-
R
E
-
L
P
D
E
L
L
A
L
V
D
I
I
T
P
N
E
T
E
A
E
K
L
T
---------
G
I
R
V
---------
E
N
D
E
D
A
A
K
A
A
Q
V
L
H
E
K
GIR
T
V
L
I
T
L
G
S
R
G
V
W
A
S
V
N
G
E
--
G
Q
R
--
V
P
G
F
R
V
Q
A
V
D
T
I
A
A
G
D
T
F
N
G
A
L
I
T
A
L
L
--
E
--
E
-
K
P
L
P
E
A
I
R
F
A
H
A
A
A
A
I
A
V
T
R
K
G
A
Q
P
S
V
P
W
R
E
E
I
D
A
F
L
D
R
Q
R
-----
10
PsiBlast_PDB
91.27
32%
-66
- C1 -
1GQT
3
RBSK_ECOLI
A:
[6-302]
--
S
L
V
V
L
G
S
I
N
A
D
H
I
L
N
L
Q
S
F
P
T
P
G
E
T
V
T
G
N
H
-
Y
Q
V
A
F
G
G
K
G
A
N
Q
A
V
A
A
G
R
S
G
A
---
N
I
A
F
I
A
C
T
G
D
D
S
I
G
E
S
V
R
Q
Q
L
A
T
D
N
I
D
I
T
P
V
-
S
V
I
K
-
G
E
S
-
T
G
V
A
L
I
F
V
-
N
G
E
G
-
E
N
V
I
G
I
H
A
G
A
N
A
A
L
S
P
A
L
V
E
A
Q
R
E
R
I
A
N
A
S
A
L
L
M
Q
L
E
S
P
L
E
S
V
M
A
A
A
K
I
A
H
Q
N
K
T
I
V
A
L
N
P
A
P
A
-
R
E
-
L
P
D
E
L
L
A
L
V
D
I
I
T
P
N
E
T
E
A
E
K
L
T
---------
G
I
R
V
---------
E
N
D
E
D
A
A
K
A
A
Q
V
L
H
E
K
GIR
T
V
L
I
T
L
G
S
R
G
V
W
A
S
V
N
G
E
--
G
Q
R
--
V
P
G
F
R
V
Q
A
V
D
T
I
A
A
G
D
T
F
N
G
A
L
I
T
A
L
L
--
E
--
E
-
K
P
L
P
E
A
I
R
F
A
H
A
A
A
A
I
A
V
T
R
K
G
A
Q
P
S
V
P
W
R
E
E
I
D
A
F
L
D
R
Q
------
8
PsiBlast_PDB
91.16
32%
-66
- C1 -
1RKA
-
RBSK_ECOLI
A:
[6-302]
--
S
L
V
V
L
G
S
I
N
A
D
H
I
L
N
L
Q
S
F
P
T
P
G
E
T
V
T
G
N
H
-
Y
Q
V
A
F
G
G
K
G
A
N
Q
A
V
A
A
G
R
S
G
A
---
N
I
A
F
I
A
C
T
G
D
D
S
I
G
E
S
V
R
Q
Q
L
A
T
D
N
I
D
I
T
P
V
-
S
V
I
K
-
G
E
S
-
T
G
V
A
L
I
F
V
-
N
G
E
G
-
E
N
V
I
G
I
H
A
G
A
N
A
A
L
S
P
A
L
V
E
A
Q
R
E
R
I
A
N
A
S
A
L
L
M
Q
L
E
S
P
L
E
S
V
M
A
A
A
K
I
A
H
Q
N
K
T
I
V
A
L
N
P
A
P
A
-
R
E
-
L
P
D
E
L
L
A
L
V
D
I
I
T
P
N
E
T
E
A
E
K
L
T
---------
G
I
R
V
---------
E
N
D
E
D
A
A
K
A
A
Q
V
L
H
E
K
GIR
T
V
L
I
T
L
G
S
R
G
V
W
A
S
V
N
G
E
--
G
Q
R
--
V
P
G
F
R
V
Q
A
V
D
T
I
A
A
G
D
T
F
N
G
A
L
I
T
A
L
L
--
E
--
E
-
K
P
L
P
E
A
I
R
F
A
H
A
A
A
A
I
A
V
T
R
K
G
A
Q
P
S
V
P
W
R
E
E
I
D
A
F
L
D
R
Q
------
31
PsiBlast_CBE
90.91
32%
-65
- C1 -
1GQT
3
RBSK_ECOLI
D:
[6-302]
--
S
L
V
V
L
G
S
I
N
A
D
H
I
L
N
L
Q
S
F
P
T
P
G
E
T
V
T
G
N
H
-
Y
Q
V
A
F
G
G
K
G
A
N
Q
A
V
A
A
G
R
S
G
A
---
N
I
A
F
I
A
C
T
G
D
D
S
I
G
E
S
V
R
Q
Q
L
A
T
D
N
I
D
I
T
P
V
-
S
V
I
K
-
G
E
S
-
T
G
V
A
L
I
F
V
-
N
G
E
G
-
E
N
V
I
G
I
H
A
G
A
N
A
A
L
S
P
A
L
V
E
A
Q
R
E
R
I
A
N
A
S
A
L
L
M
Q
L
E
S
P
L
E
S
V
M
A
A
A
K
I
A
H
Q
N
K
T
I
V
A
L
N
P
A
P
A
-
R
E
-
L
P
D
E
L
L
A
L
V
D
I
I
T
P
N
E
T
E
A
E
K
L
T
---------
G
I
R
V
---------
E
N
D
E
D
A
A
K
A
A
Q
V
L
HEKGIRTVL
I
T
L
G
S
R
G
V
W
A
S
V
N
G
E
--
G
Q
R
--
V
P
G
F
R
V
Q
A
V
D
T
I
A
A
G
D
T
F
N
G
A
L
I
T
A
L
L
--
E
--
E
-
K
P
L
P
E
A
I
R
F
A
H
A
A
A
A
I
A
V
T
R
K
G
A
Q
P
S
V
P
W
R
E
E
I
D
A
F
L
D
R
Q
------
33
PsiBlast_CBE
90.88
32%
-65
- C1 -
1GQT
3
RBSK_ECOLI
B:
[6-302]
--
S
L
V
V
L
G
S
I
N
A
D
H
I
L
N
L
Q
S
F
P
T
P
G
E
T
V
T
G
N
H
-
Y
Q
V
A
F
G
G
K
G
A
N
Q
A
V
A
A
G
R
S
G
A
---
N
I
A
F
I
A
C
T
G
D
D
S
I
G
E
S
V
R
Q
Q
L
A
T
D
N
I
D
I
T
P
V
-
S
V
I
K
-
G
E
S
-
T
G
V
A
L
I
F
V
-
N
G
E
G
-
E
N
V
I
G
I
H
A
G
A
N
A
A
L
S
P
A
L
V
E
A
Q
R
E
R
I
A
N
A
S
A
L
L
M
Q
L
E
S
P
L
E
S
V
M
A
A
A
K
I
A
H
Q
N
K
T
I
V
A
L
N
P
A
P
A
-
R
E
-
L
P
D
E
L
L
A
L
V
D
I
I
T
P
N
E
T
E
A
E
K
L
T
---------
G
I
R
V
---------
E
N
D
E
D
A
A
K
A
A
Q
V
L
H
E
K
GIR
T
V
L
I
T
L
G
S
R
G
V
W
A
S
V
N
G
E
--
G
Q
R
--
V
P
G
F
R
V
Q
A
V
D
T
I
A
A
G
D
T
F
N
G
A
L
I
T
A
L
L
--
E
--
E
-
K
P
L
P
E
A
I
R
F
A
H
A
A
A
A
I
A
V
T
R
K
G
A
Q
P
S
V
P
W
R
E
E
I
D
A
F
L
D
R
Q
------
59
HHSearch
90.55
32%
-72
- C1 -
2FV7
8
RBSK_HUMAN
A:
[24-330]
V
A
A
V
V
V
V
G
S
C
M
T
D
L
V
S
L
T
S
R
L
P
K
T
G
E
T
I
H
G
H
K
-
F
F
I
G
F
G
G
K
G
A
N
Q
C
V
Q
A
A
R
L
G
-
A
--
M
T
S
M
V
C
K
V
G
K
D
S
F
G
N
D
Y
I
E
N
L
K
Q
N
D
I
S
T
E
F
T
-
Y
Q
T
K
D
A
-
A
-
T
G
T
A
S
I
I
V
N
N
E
-
G
-
Q
N
I
I
V
I
V
A
G
A
N
L
L
L
N
T
E
D
L
R
A
A
A
N
V
I
S
R
A
K
V
M
V
C
Q
L
E
I
T
P
A
T
S
L
E
A
L
T
M
A
R
R
S
G
V
K
T
L
F
N
P
A
P
A
-
I
A
D
L
D
P
Q
F
Y
T
L
S
D
V
F
C
C
N
E
S
E
A
E
I
L
T
---------
G
L
T
V
GS
A
A
D
A
G
E
A
A
L
V
L
L
K
R
G
C
Q
V
V
I
---------
I
T
L
G
A
E
G
C
V
V
L
S
Q
T
E
P
E
P
K
H
--
I
P
T
E
K
V
K
A
V
D
T
T
G
A
G
D
S
F
V
G
A
L
A
F
Y
L
A
--
Y
YP
N
-
L
S
L
E
D
M
L
N
R
S
N
F
I
A
A
V
S
V
Q
A
A
G
T
Q
S
S
Y
P
Y
K
K
D
L
P
L
T
L
F
--------
7
PsiBlast_PDB
90.27
32%
-64
- C1 -
1RK2
4
RBSK_ECOLI
A:
[6-302]
--
S
L
V
V
L
G
S
I
N
A
D
H
I
L
N
L
Q
S
F
P
T
P
G
E
T
V
T
G
N
H
-
Y
Q
V
A
F
G
G
K
G
A
N
Q
A
V
A
A
G
R
S
G
A
---
N
I
A
F
I
A
C
T
G
D
D
S
I
G
E
S
V
R
Q
Q
L
A
T
D
N
I
D
I
T
P
V
-
S
V
I
K
-
G
E
S
-
T
G
V
A
L
I
F
V
-
N
G
E
G
-
E
N
V
I
G
I
H
A
G
A
N
A
A
L
S
P
A
L
V
E
A
Q
R
E
R
I
A
N
A
S
A
L
L
M
Q
L
E
S
P
L
E
S
V
M
A
A
A
K
I
A
H
Q
N
K
T
I
V
A
L
N
P
A
P
A
-
R
E
-
L
P
D
E
L
L
A
L
V
D
I
I
T
P
N
E
T
E
A
E
K
L
T
---------
G
I
R
V
---------
E
N
D
E
D
A
A
K
A
A
Q
V
L
H
E
K
GIR
T
V
L
I
T
L
G
S
R
G
V
W
A
S
V
N
G
E
--
G
Q
R
--
V
P
G
F
R
V
Q
A
V
D
T
I
A
A
G
D
T
F
N
G
A
L
I
T
A
L
L
--
E
--
E
-
K
P
L
P
E
A
I
R
F
A
H
A
A
A
A
I
A
V
T
R
K
G
A
Q
P
S
V
P
W
R
E
E
I
D
A
F
L
D
R
Q
------
9
PsiBlast_PDB
90.25
32%
-66
- C1 -
1RKS
3
RBSK_ECOLI
A:
[6-302]
--
S
L
V
V
L
G
S
I
N
A
D
H
I
L
N
L
Q
S
F
P
T
P
G
E
T
V
T
G
N
H
-
Y
Q
V
A
F
G
G
K
G
A
N
Q
A
V
A
A
G
R
S
G
A
---
N
I
A
F
I
A
C
T
G
D
D
S
I
G
E
S
V
R
Q
Q
L
A
T
D
N
I
D
I
T
P
V
-
S
V
I
K
-
G
E
S
-
T
G
V
A
L
I
F
V
-
N
G
E
G
-
E
N
V
I
G
I
H
A
G
A
N
A
A
L
S
P
A
L
V
E
A
Q
R
E
R
I
A
N
A
S
A
L
L
M
Q
L
E
S
P
L
E
S
V
M
A
A
A
K
I
A
H
Q
N
K
T
I
V
A
L
N
P
A
P
A
-
R
E
-
L
P
D
E
L
L
A
L
V
D
I
I
T
P
N
E
T
E
A
E
K
L
T
---------
G
I
R
V
---------
E
N
D
E
D
A
A
K
A
A
Q
V
L
H
E
K
GIR
T
V
L
I
T
L
G
S
R
G
V
W
A
S
V
N
G
E
--
G
Q
R
--
V
P
G
F
R
V
Q
A
V
D
T
I
A
A
G
D
T
F
N
G
A
L
I
T
A
L
L
--
E
--
E
-
K
P
L
P
E
A
I
R
F
A
H
A
A
A
A
I
A
V
T
R
K
G
A
Q
P
S
V
P
W
R
E
E
I
D
A
F
L
D
R
Q
------
2
PsiBlast_PDB
90.09
33%
-73
- C1 -
4X8F
-
?
A:
[4-302]
M
N
K
L
V
V
L
G
S
V
N
A
D
H
V
L
Q
V
P
S
F
P
R
P
G
E
T
L
H
G
R
N
-
Y
Q
V
I
P
G
G
K
G
A
N
Q
A
V
A
A
A
R
M
Q
A
D
---
V
G
F
I
A
C
V
G
D
D
S
F
G
I
N
I
R
E
S
F
K
L
D
G
I
N
T
A
G
V
-
K
L
Q
P
-
N
-
C
P
T
G
I
A
M
I
Q
V
-
S
D
-
S
G
E
N
S
I
C
I
S
A
E
A
N
A
K
L
T
A
A
A
I
E
P
D
L
A
A
I
R
D
A
R
Y
L
L
M
Q
L
E
T
P
L
D
G
I
L
K
A
A
Q
E
A
K
T
A
K
T
N
V
I
L
N
P
A
P
A
-
R
E
-
L
P
D
E
L
L
K
C
V
D
L
I
T
P
N
E
T
E
A
E
V
L
T
GITVYD
D
S
S
A
Q
Q
A
---------
A
D
A
L
H
C
K
G
I
E
I
V
I
---------
I
T
L
G
S
K
G
V
W
L
S
Q
N
G
R
--
G
Q
R
--
I
P
G
F
V
V
K
A
T
D
T
T
A
A
G
D
T
F
N
G
A
L
V
T
G
L
L
--
Q
--
E
-
M
P
L
E
S
A
I
K
F
A
H
A
A
A
A
I
S
V
T
R
F
G
A
Q
T
S
I
P
T
R
A
E
V
E
A
F
L
A
E
H
S
-----
32
PsiBlast_CBE
89.51
32%
-65
- C1 -
1GQT
3
RBSK_ECOLI
C:
[6-302]
--
S
L
V
V
L
G
S
I
N
A
D
H
I
L
N
L
Q
S
F
P
T
P
G
E
T
V
T
G
N
H
-
Y
Q
V
A
F
G
G
K
G
A
N
Q
A
V
A
A
G
R
S
G
A
---
N
I
A
F
I
A
C
T
G
D
D
S
I
G
E
S
V
R
Q
Q
L
A
T
D
N
I
D
I
T
P
V
-
S
V
I
K
-
G
E
S
-
T
G
V
A
L
I
F
V
-
N
G
E
G
-
E
N
V
I
G
I
H
A
G
A
N
A
A
L
S
P
A
L
V
E
A
Q
R
E
R
I
A
N
A
S
A
L
L
M
Q
L
E
S
P
L
E
S
V
M
A
A
A
K
I
A
H
Q
N
K
T
I
V
A
L
N
P
A
P
A
-
R
E
-
L
P
D
E
L
L
A
L
V
D
I
I
T
P
N
E
T
E
A
E
K
L
T
---------
G
I
R
V
---------
E
N
D
E
D
A
A
K
A
A
Q
V
L
HEKGIRTVL
I
T
L
G
S
R
G
V
W
A
S
V
N
G
E
--
G
Q
R
--
V
P
G
F
R
V
Q
A
V
D
T
I
A
A
G
D
T
F
N
G
A
L
I
T
A
L
L
--
E
--
E
-
K
P
L
P
E
A
I
R
F
A
H
A
A
A
A
I
A
V
T
R
K
G
A
Q
P
S
V
P
W
R
E
E
I
D
A
F
L
D
R
Q
R
-----
29
PsiBlast_CBE
89.36
32%
-65
- C1 -
1RK2
4
RBSK_ECOLI
C:
[6-302]
--
S
L
V
V
L
G
S
I
N
A
D
H
I
L
N
L
Q
S
F
P
T
P
G
E
T
V
T
G
N
H
-
Y
Q
V
A
F
G
G
K
G
A
N
Q
A
V
A
A
G
R
S
G
A
---
N
I
A
F
I
A
C
T
G
D
D
S
I
G
E
S
V
R
Q
Q
L
A
T
D
N
I
D
I
T
P
V
-
S
V
I
K
-
G
E
S
-
T
G
V
A
L
I
F
V
-
N
G
E
G
-
E
N
V
I
G
I
H
A
G
A
N
A
A
L
S
P
A
L
V
E
A
Q
R
E
R
I
A
N
A
S
A
L
L
M
Q
L
E
S
P
L
E
S
V
M
A
A
A
K
I
A
H
Q
N
K
T
I
V
A
L
N
P
A
P
A
-
R
E
-
L
P
D
E
L
L
A
L
V
D
I
I
T
P
N
E
T
E
A
E
K
L
T
---------
G
I
R
V
---------
E
N
D
E
D
A
A
K
A
A
Q
V
L
HEKGIRTVL
I
T
L
G
S
R
G
V
W
A
S
V
N
G
E
--
G
Q
R
--
V
P
G
F
R
V
Q
A
V
D
T
I
A
A
G
D
T
F
N
G
A
L
I
T
A
L
L
--
E
--
E
-
K
P
L
P
E
A
I
R
F
A
H
A
A
A
A
I
A
V
T
R
K
G
A
Q
P
S
V
P
W
R
E
E
I
D
A
F
L
D
R
Q
R
-----
30
PsiBlast_CBE
89.31
32%
-66
- C1 -
1RK2
5
RBSK_ECOLI
B:
[6-302]
--
S
L
V
V
L
G
S
I
N
A
D
H
I
L
N
L
Q
S
F
P
T
P
G
E
T
V
T
G
N
H
-
Y
Q
V
A
F
G
G
K
G
A
N
Q
A
V
A
A
G
R
S
G
A
---
N
I
A
F
I
A
C
T
G
D
D
S
I
G
E
S
V
R
Q
Q
L
A
T
D
N
I
D
I
T
P
V
-
S
V
I
K
-
G
E
S
-
T
G
V
A
L
I
F
V
-
N
G
E
G
-
E
N
V
I
G
I
H
A
G
A
N
A
A
L
S
P
A
L
V
E
A
Q
R
E
R
I
A
N
A
S
A
L
L
M
Q
L
E
S
P
L
E
S
V
M
A
A
A
K
I
A
H
Q
N
K
T
I
V
A
L
N
P
A
P
A
-
R
E
-
L
P
D
E
L
L
A
L
V
D
I
I
T
P
N
E
T
E
A
E
K
L
T
---------
G
I
R
V
---------
E
N
D
E
D
A
A
K
A
A
Q
V
L
H
E
K
GIR
T
V
L
I
T
L
G
S
R
G
V
W
A
S
V
N
G
E
--
G
Q
R
--
V
P
G
F
R
V
Q
A
V
D
T
I
A
A
G
D
T
F
N
G
A
L
I
T
A
L
L
--
E
--
E
-
K
P
L
P
E
A
I
R
F
A
H
A
A
A
A
I
A
V
T
R
K
G
A
Q
P
S
V
P
W
R
E
E
I
D
A
F
L
D
R
Q
------
28
PsiBlast_CBE
89.21
32%
-66
- C1 -
1RK2
5
RBSK_ECOLI
D:
[6-302]
--
S
L
V
V
L
G
S
I
N
A
D
H
I
L
N
L
Q
S
F
P
T
P
G
E
T
V
T
G
N
H
-
Y
Q
V
A
F
G
G
K
G
A
N
Q
A
V
A
A
G
R
S
G
A
---
N
I
A
F
I
A
C
T
G
D
D
S
I
G
E
S
V
R
Q
Q
L
A
T
D
N
I
D
I
T
P
V
-
S
V
I
K
-
G
E
S
-
T
G
V
A
L
I
F
V
-
N
G
E
G
-
E
N
V
I
G
I
H
A
G
A
N
A
A
L
S
P
A
L
V
E
A
Q
R
E
R
I
A
N
A
S
A
L
L
M
Q
L
E
S
P
L
E
S
V
M
A
A
A
K
I
A
H
Q
N
K
T
I
V
A
L
N
P
A
P
A
-
R
E
-
L
P
D
E
L
L
A
L
V
D
I
I
T
P
N
E
T
E
A
E
K
L
T
---------
G
I
R
V
---------
E
N
D
E
D
A
A
K
A
A
Q
V
L
HEKGIRTVL
I
T
L
G
S
R
G
V
W
A
S
V
N
G
E
--
G
Q
R
--
V
P
G
F
R
V
Q
A
V
D
T
I
A
A
G
D
T
F
N
G
A
L
I
T
A
L
L
--
E
--
E
-
K
P
L
P
E
A
I
R
F
A
H
A
A
A
A
I
A
V
T
R
K
G
A
Q
P
S
V
P
W
R
E
E
I
D
A
F
L
D
R
Q
------
61
HHSearch
86.49
32%
-73
- C1 -
3RY7
2
?
A:
[2-303]
T
N
K
V
V
I
L
G
S
T
N
V
D
Q
F
L
T
V
E
R
Y
A
Q
P
G
E
T
L
H
V
E
E
A
Q
K
A
F
G
G
G
K
G
A
N
Q
A
I
A
T
A
R
M
Q
-
A
--
D
T
T
F
I
T
K
I
G
T
D
G
V
A
D
F
I
L
E
D
F
K
V
A
H
I
D
T
S
Y
I
-
I
K
T
A
E
A
-
K
-
T
G
Q
A
F
I
T
V
N
A
E
-
G
-
Q
N
T
I
Y
V
Y
G
G
A
N
M
T
M
T
P
E
D
V
I
N
A
K
D
A
I
I
N
A
D
F
V
V
A
Q
L
E
V
P
I
P
A
I
I
S
A
F
E
I
A
K
A
H
G
V
T
T
V
L
N
P
A
P
A
-
K
A
-
L
P
N
E
L
L
S
L
I
D
I
I
V
P
N
E
T
E
A
E
L
L
S
---------
G
I
K
V
T
N
E
Q
S
M
K
D
N
A
N
Y
F
L
S
I
G
I
K
T
V
L
---------
I
T
L
G
K
Q
G
T
Y
F
A
T
K
N
Q
--
S
Q
H
--
I
E
A
Y
K
V
N
A
I
D
T
T
A
A
G
D
T
F
I
G
A
F
V
S
R
L
N
--
K
--
S
Q
D
N
L
A
D
A
I
D
F
G
N
K
A
S
S
L
T
V
Q
K
H
G
A
Q
A
S
I
P
L
L
E
E
V
N
Q
V
----------
6
PsiBlast_PDB
85.27
31%
-63
- C1 -
2FV7
8
RBSK_HUMAN
A:
[31-326]
-------
G
S
C
M
T
D
L
V
S
L
T
S
R
L
P
K
T
G
E
T
I
H
G
H
K
-
F
F
I
G
F
G
G
K
G
A
N
Q
C
V
Q
A
A
R
L
G
A
---
M
T
S
M
V
C
K
V
G
K
D
S
F
G
N
D
Y
I
E
N
L
K
Q
N
D
I
S
T
E
F
T
Y
Q
T
K
D
-
A
-
A
-
T
G
T
A
S
I
I
V
-
N
N
E
G
-
Q
N
I
I
V
I
V
A
G
A
N
L
L
L
N
T
E
D
L
R
A
A
A
N
V
I
S
R
A
K
V
M
V
C
Q
L
E
I
T
P
A
T
S
L
E
A
L
T
M
A
R
R
S
G
V
K
T
L
F
N
P
A
P
A
I
A
D
-
L
D
P
Q
F
Y
T
L
S
D
V
F
C
C
N
E
S
E
A
E
I
L
T
GLTVGS
A
A
D
A
G
E
A
---------
A
L
V
L
L
K
R
G
C
Q
V
V
I
---------
I
T
L
G
A
E
G
C
V
V
L
S
Q
T
E
--
P
E
P
K
H
I
P
T
E
K
V
K
A
V
D
T
T
G
A
G
D
S
F
V
G
A
L
A
F
Y
L
A
YY
P
--
N
-
L
S
L
E
D
M
L
N
R
S
N
F
I
A
A
V
S
V
Q
A
A
G
T
Q
S
S
Y
P
Y
K
K
D
L
P
L
T
L
F
--------
27
PsiBlast_CBE
85.04
31%
-60
- C1 -
2FV7
9
RBSK_HUMAN
B:
[31-326]
-------
G
S
C
M
T
D
L
V
S
L
T
S
R
L
P
K
T
G
E
T
I
H
G
H
K
-
F
F
I
G
F
G
G
K
G
A
N
Q
C
V
Q
A
A
R
L
G
A
---
M
T
S
M
V
C
K
V
G
K
D
S
F
G
N
D
Y
I
E
N
L
K
Q
N
D
I
S
T
E
F
T
Y
Q
T
K
D
-
A
-
A
-
T
G
T
A
S
I
I
V
-
N
N
E
G
-
Q
N
I
I
V
I
V
A
G
A
N
L
L
L
N
T
E
D
L
R
A
A
A
N
V
I
S
R
A
K
V
M
V
C
Q
L
E
I
T
P
A
T
S
L
E
A
L
T
M
A
R
R
S
G
V
K
T
L
F
N
P
A
P
A
I
A
D
-
L
D
P
Q
F
Y
T
L
S
D
V
F
C
C
N
E
S
E
A
E
I
L
T
GLTVGSAAD
A
G
E
A
---------
A
L
V
L
L
K
R
G
C
Q
V
V
I
---------
I
T
L
G
A
E
G
C
V
V
L
S
Q
T
E
--
P
E
P
KH
I
P
T
E
K
V
K
A
V
D
T
T
G
A
G
D
S
F
V
G
A
L
A
F
Y
L
A
YY
P
--
N
-
L
S
L
E
D
M
L
N
R
S
N
F
I
A
A
V
S
V
Q
A
A
G
T
Q
S
S
Y
P
Y
K
K
D
L
P
L
T
L
F
--------