@TOME V2.3
(Nov 2016)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : gbs0492: (2015-12-01 )
MSKELSPKYNPAEVEEGRYQTWLDQDVFKPSGDTEAKPYSIVIPPPNVTGKLHLGHAWDTTLQDIIIRQKRMQGFDTLWLPGMDHAGIATQAKVEERLREQGISRYDLGREKFLDKVWEWKDEYAATIKSQWGKMGLSVDYSRERFTLDEGLSKAVRKVFVDLYNKGWIYRGEFIINWDPAARTALSDIEVIHKDVEGAFYHMNYMLEDGSRALEVATTRPETMFGDVAVAVNPEDPRYKDLIGQNVILPIINKPIPIIADEHADPEFGTGVVKITPAHDPNDFAVGQRHNLPQVNVMNDDGTMNELADEFNGMDRFEARKAVVAKLESLGNLVKIEKMTHSVGHSERTGVVVEPRLSTQWFVKMDQLAKNAIANQDTEDKVEFYPPRFNDTFMSWMENVHDWVISRQLWWGHQIPAWYNVNGEMYVGEDAPEGDGWTQDEDVLDTWFSSALWPFSTMGWPDTEAADFKRYFPTSTLVTGYDIIFFWVSRMIFQSLEFTGRQPFSNVLIHGLIRDEEGRKMSKSLGNGIDPMDVIEKYGADALRWFLSNGSAPGQDVRFSYEKMDASWNFINKIWNISRYILMNNEGLTLDQARENVEKVVNSQVGNVTDRWILHNLNETVGKVTESFDKFEFGVAGHILYNFIWEEFANWYVELTKEVLYSDNEDEKVVTRSVLLYTLDQILRLLHPIMPFVTEEIFGQYAEGSIVLASYPQVNATFENQTAHKGVESLKDLIRSVRNSRAEVNVAPSKPITILVKTSDSELESFFKDNSNYIKRFTNPETLEISSAITAPELAMTSIITGAEIFLPLADLLNVEEELARLEKELAKWQKELNMVGKKLSNERFVANAKPEVVQKEKDKQTDYQTKYDATIARIEEMKKLNND
Atome Classification :
(20 SA)
---------.........10........20........30..--.--.--....40...-.....50........60........70........80........90.......-----.100-.-........110.......120.......130.......140.......150.......160.......170.......180.......190-.------------.-------------------------------------------..-----------....200-----------------------------------...--------------------------------------......210----..------...------....220.......230-------------...--------------------------------------...---------.-----------------------------------240..-----------------------------------.--------------------.....------------.-------------------------------------250---.....--------..260.......270.......280.......290.-.....---------------.300..--..--------------.--.--.-------------310.......320.......330......---------------.340.......350.......360.....------------..370.-......380.......390........400.....--------..410.......-------420..-.---------------------.....----------.------------------------430--------------------------.-------------------------.--.------------------.-----------...-----..440.......450.---------......460------..----......470.......480------.......490-------......--.----500.......510.-------------------------..----------------------------------------------...-------.------------------520.......530.......540.......550.......560..-..-...570.......580.......590.......600.......610.......620.......630-.........640.......650.......660.--...--...--670.......680.......690......-.---700------.-.-------.---.....710.......720.......----..730.......740.......750.......760.......770.......780.......790.......800.......810.......820.......830.......840.......850.......860.......870.......880..
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
---------MSKELSPKY
N
P
A
E
V
EEGR
Y
Q
T
W
L
DQDVFKPSGD--T--E--A
K
P
Y
S
I
V
IP-PPNV
T
G
K
L
H
LGHA
W
D
T
T
L
Q
D
I
I
I
R
Q
K
R
MQGFDTLWLPGMDHAGI
A
T
Q
A
K
V
E
E
R
L
-----
R
E
---Q-GISRYDL
G
R
E
K
F
L
D
K
V
W
E
W
K
D
E
Y
A
A
T
I
K
S
Q
WGKMG
L
S
V
DYSRERF
T
L
D
E
G
L
S
K
A
V
R
K
V
F
V
D
L
YNK
G
W
I
Y
R
G
E
F
I
I
NWDP
A
A
R
T
A
L
S
D
I
E
V
--
I
------------
H
-------------------------------------------
K
D-----------VE
G
A
F
-------------------------------------
Y
H
M
--------------------------------------
N
Y
M
LEDG------S
R
------
A
L
E
------
V
ATTRPE
T
M
FG
D
V
A
V
A
V-------------NPE--------------------------------------DP
R
---------
Y
-----------------------------------
K
--
D
L-----------------------------------I--------------------GQN
V
I
------------
L
-------------------------------------
P
II---NKPI
P
--------
I
I
ADEHADPEFGT
G
V
V
K
I
TPAHDPNDFAVGQRHNL
P
-
Q
V
N
V
M---------------NDDG
T
M
--
N
E
--------------
L
--
A
--
D
-------------
E
FNG
M
D
R
F
E
A
R
K
A
V
V
A
K
L
E
SLG
N
L
V
K
I
E
K
---------------
M
T
H
SVGHSERT
G
V
V
VEPRLS
T
Q
W
F
V
K
M
D
Q
------------
L
A
K
N
AI-ANQDTEDK
V
E
FYPPRF
N
D
-
T
F
M
S
W
M
E
N
V
H
D
W
V
I
S
R
--------QLWWGHQI
P
A
W
Y
-------N--VN-G---------------------
E
M
Y
VG----------E------------------------D----------------------------A-------------------------P--E------------------G-----------DGW-----T
Q
D
E
D
V
L
D
T
W
F
S
SALW---------PFSTMGWP-------DT----
E
A
A
D
F
K
R
YFPTSTLVT
G
Y
D
------
I
I
F
F
W
V
S
R
M
I
-------
F
Q
S
L
EF--T----GRQP
F
S
N
V
L
I
H
G
L
I-------------------------RD----------------------------------------------EEG-------
R
------------------
K
M
S
K
S
LGNGI
D
P
M
D
V
I
E
K
YG
A
D
A
L
R
W
F
L
SNGSAPGQD
V
R
F
S
Y
EKM-DA-
S
W
N
F
I
N
K
I
WN
I
S
R
Y
I
L
MNNEGL
T
L
D
Q
A
R
E
N
V
E
K
V
V
N
S
QVGN
V
T
D
R
W
I
L
H
N
L
N
E
T
V
G
K
V
T
E
S
F
D
K
---
F
E
FG
V
A
G
H
I
L
Y
N
F
I
W
E
E
F
A
N
W
Y
V
E
L
T
K
E
V
LYSD--NED--
E
K
V
--
V
T
R
S
V
L
L
Y
T
L
D
Q
I
L
R
L
L
H
P
I
M
P
F
V
T
E
E
I
F
-
G
---QY-------A-E-------G---
S
I
V
L
A
SYPQV
N
A
TFEN--
Q
T
A
H
K
G
V
----
E
S
L
K
D
L
I
R
S
V
RNSR
A
E
V
NVAPSK
P
I
T
I
L
V
KTS
D
S
E
L
E
S
F
F
KDN
S
N
Y
I
K
RFTNP
E
T
L
E
ISSAITA
P
E
L
A
M
T
S
I
ITG
A
E
I
F
L
P
L
A
D
L
L
N
V
E
E
E
L
A
R
L
E
K
E
L
A
K
W
Q
K
E
L
N
M
V
G
K
KLSNE
R
F
VANAK
P
E
V
V
Q
KEKDKQTDYQTK
Y
D
A
T
I
A
R
I
E
E
M
K
K
LNND
102
Fugue
97.86
39%
-66
- C1 -
1GAX
3
SYV_THETH
A:
[1-862]
-----------
M
D
L
P
K
A
Y
D
P
K
S
V
E
P
K
W
A
E
K
W
A
K
N
P
-
F
V
A
N
P
K
--
S
--
G
--
K
P
P
F
V
I
F
M
P
-
P
P
N
V
T
G
S
L
H
M
G
H
A
L
D
N
S
L
Q
D
A
L
I
R
Y
K
R
M
R
G
F
E
A
V
W
L
P
G
T
D
H
A
G
I
A
T
Q
V
V
V
E
R
L
L
-----
L
K
---
E
-
G
K
T
R
H
D
L
G
R
E
K
F
L
E
R
V
W
Q
W
K
E
E
S
G
G
T
I
L
K
Q
L
K
R
L
G
A
S
A
D
W
S
R
E
A
F
T
M
D
E
K
R
S
R
A
V
R
Y
A
F
S
R
Y
Y
H
E
G
L
A
Y
R
A
P
R
L
V
N
W
C
P
R
C
E
T
T
L
S
D
L
E
V
--
E
------------
T
-------------------------------------------
E
P
-----------
T
P
G
K
L
-------------------------------------
Y
T
L
--------------------------------------
R
Y
E
V
E
G
G
------
G
F
-------
I
E
------
I
A
T
V
R
P
E
T
V
F
A
D
Q
A
I
A
V
-------------
H
P
E
--------------------------------------
D
E
R
---------
Y
-----------------------------------
R
--
H
L
-----------------------------------
L
--------------------
G
K
R
A
R
------------
I
-------------------------------------
P
L
T
---
E
V
W
I
P
--------
I
L
A
D
P
A
V
E
K
D
F
G
T
G
A
L
K
V
T
P
A
H
D
P
L
D
Y
E
I
G
E
R
H
G
L
K
-
P
V
S
V
I
---------------
N
L
E
G
R
M
--
E
G
--------------
E
--
R
VP
E
-------------
A
L
R
G
L
D
R
F
E
A
R
R
K
A
V
E
L
F
R
E
A
G
H
L
V
K
E
E
D
---------------
Y
T
I
A
L
A
T
C
S
R
C
G
T
P
I
E
Y
A
I
F
P
Q
W
W
L
R
M
R
P
------------
L
A
E
E
V
L
-
K
G
L
R
R
-
G
D
I
A
F
V
P
E
R
W
K
K
-
V
N
M
D
W
L
E
N
V
K
D
W
N
I
S
R
--------
Q
L
W
W
G
H
Q
I
P
A
W
Y
C
------
E
--
D
C
-
Q
---------------------
A
V
N
V
P
----------
R
------------------------
P
----------------------------
E
-------------------------
R
--
Y
------------------
L
EDPTSCEACGS
P
R
L
-----
K
R
D
E
D
V
F
D
T
W
F
S
S
A
L
W
---------
P
L
S
T
L
G
W
P
-------
E
E
----
T
-
E
D
L
K
A
F
Y
P
G
D
V
L
V
T
G
Y
D
------
I
L
F
L
W
V
S
R
M
E
-------
V
S
G
Y
H
F
--
M
----
G
E
R
P
F
K
T
V
L
L
H
G
L
V
-------------------------
L
D
----------------------------------------------
E
K
G
-------
Q
------------------
K
M
S
K
S
K
G
N
V
I
D
P
L
E
M
V
E
R
Y
G
A
D
A
L
R
F
A
L
I
Y
L
A
T
G
G
Q
D
I
R
L
D
L
R
W
L
-
E
M
-
A
R
N
F
A
N
K
L
Y
N
A
A
R
F
V
L
L
S
R
E
G
F
Q
A
K
E
D
T
P
T
-----------
L
A
D
R
F
M
R
S
R
L
S
R
G
V
E
E
I
T
A
L
Y
E
A
---
L
D
L
A
Q
A
A
R
E
V
Y
E
L
V
W
S
E
F
C
D
W
Y
L
E
A
A
K
P
A
L
K
A
G
--
N
------
A
--
H
T
L
R
T
L
E
E
V
L
A
V
L
L
K
L
L
H
P
M
M
P
F
L
T
S
E
L
Y
-
Q
---
A
L
-------
T
G
K
-------
E
---
E
L
A
L
E
A
W
P
E
P
G
G
--
R
D
--
E
E
A
E
R
A
F
----
E
A
L
K
Q
A
V
T
A
V
R
A
L
K
A
E
A
G
L
P
P
A
Q
E
V
R
V
Y
L
E
G
E
T
A
P
V
E
E
----
N
L
E
V
F
R
F
L
S
R
-----
A
D
L
L
P
E
R
P
A
K
A
L
V
K
A
M
P
R
V
T
A
R
M
P
L
E
G
L
L
D
V
E
E
W
R
R
R
Q
E
K
R
L
K
E
L
L
A
L
A
E
R
S
Q
R
K
L
A
S
P
G
F
R
E
K
A
P
K
E
V
V
E
A
E
E
A
R
L
K
E
N
L
E
Q
A
E
R
I
R
E
A
L
S
Q
I
G
-----
79
HHSearch
97.57
39%
-69
- C1 -
1GAX
3
SYV_THETH
A:
[2-862]
------------
D
L
P
K
A
Y
D
P
K
S
V
E
P
K
W
A
E
K
W
A
K
N
P
-
F
V
A
N
P
K
--
S
--
G
--
K
P
P
F
V
I
F
M
P
-
P
P
N
V
T
G
S
L
H
M
G
H
A
L
D
N
S
L
Q
D
A
L
I
R
Y
K
R
M
R
G
F
E
A
V
W
L
P
G
T
D
H
A
G
I
A
T
Q
V
V
V
E
R
L
L
-----
L
K
---
E
-
G
K
T
R
H
D
L
G
R
E
K
F
L
E
R
V
W
Q
W
K
E
E
S
G
G
T
I
L
K
Q
L
K
R
L
G
A
S
A
D
W
S
R
E
A
F
T
M
D
E
K
R
S
R
A
V
R
Y
A
F
S
R
Y
Y
H
E
G
L
A
Y
R
A
P
R
L
V
N
W
C
P
R
C
E
T
T
L
S
D
L
E
V
--
E
------------
T
-------------------------------------------
E
P
-----------
T
P
G
K
L
-------------------------------------
Y
T
L
--------------------------------------
R
Y
E
V
E
G
-------
G
G
------
F
I
E
------
I
A
T
V
R
P
E
T
V
F
A
D
Q
A
I
A
V
-------------
H
P
E
--------------------------------------
D
E
R
---------
Y
-----------------------------------
R
--
H
L
-----------------------------------
L
--------------------
G
K
R
A
R
------------
I
-------------------------------------
P
L
T
---
E
V
W
I
P
--------
I
L
A
D
P
A
V
E
K
D
F
G
T
G
A
L
K
V
T
P
A
H
D
P
L
D
Y
E
I
G
E
R
H
G
L
K
-
P
V
S
V
I
---------------
N
L
E
G
R
M
--
E
G
--------------
E
RV
P
--
E
-------------
A
L
R
G
L
D
R
F
E
A
R
R
K
A
V
E
L
F
R
E
A
G
H
L
V
K
E
E
D
---------------
Y
T
I
A
L
A
T
C
S
R
C
G
T
P
I
E
Y
A
I
F
P
Q
W
W
L
R
M
R
P
------------
L
A
E
E
V
L
-
K
G
L
R
-
R
G
D
I
A
F
V
P
E
R
W
K
K
-
V
N
M
D
W
L
E
N
V
K
D
W
N
I
S
R
--------
Q
L
W
W
G
H
Q
I
P
A
W
Y
-------
C
--
E
D
C
Q
---------------------
A
V
N
V
P
----------
R
------------------------
P
ERYLEDPTSCE-----------------
A
-------------------------
C
--
G
------------------
S
-----------
P
R
L
-----
K
R
D
E
D
V
F
D
T
W
F
S
S
A
L
W
---------
P
L
S
T
L
G
W
P
-------
E
E
-----
T
E
D
L
K
A
F
Y
P
G
D
V
L
V
T
G
Y
D
------
I
L
F
L
W
V
S
R
M
E
-------
V
S
G
Y
H
F
--
M
----
G
E
R
P
F
K
T
V
L
L
H
G
L
V
-------------------------
L
D
----------------------------------------------
E
K
G
-------
Q
------------------
K
M
S
K
S
K
G
N
V
I
D
P
L
E
M
V
E
R
Y
G
A
D
A
L
R
F
A
L
I
Y
L
A
T
G
G
Q
D
I
R
L
D
L
R
W
L
-
E
M
-
A
R
N
F
A
N
K
L
Y
N
A
A
R
F
V
L
L
S
R
E
G
F
Q
A
-----------
K
E
D
T
P
T
L
A
D
R
F
M
R
S
R
L
S
R
G
V
E
E
I
T
A
L
Y
E
A
---
L
D
L
A
Q
A
A
R
E
V
Y
E
L
V
W
S
E
F
C
D
W
Y
L
E
A
A
K
P
A
L
K
A
G
--
N
------
A
--
H
T
L
R
T
L
E
E
V
L
A
V
L
L
K
L
L
H
P
M
M
P
F
L
T
S
E
L
Y
-
Q
---
A
L
-------
T
-
G
-------
K
E--
E
L
A
L
E
A
W
P
E
P
G
G
--
R
D
--
E
E
A
E
R
A
F
----
E
A
L
K
Q
A
V
T
A
V
R
A
L
K
A
E
A
G
L
P
P
A
Q
E
V
R
V
Y
L
E
G
E
T
A
----
P
V
E
E
N
L
E
V
F
R
F
L
S
R
A
D
L
L
P
---
E
--
R
P
A
K
A
L
V
K
A
M
P
R
V
T
A
R
M
P
L
E
G
L
L
D
V
E
E
W
R
R
R
Q
E
K
R
L
K
E
L
L
A
L
A
E
R
S
Q
R
K
L
A
S
P
G
F
R
E
K
A
P
K
E
V
V
E
A
E
E
A
R
L
K
E
N
L
E
Q
A
E
R
I
R
E
A
L
S
Q
I
G
-----
21
PsiBlast_CBE
96.80
39%
-65
- C1 -
1IVS
1
SYV_THETH
B:
[2-843]
------------
D
L
P
K
A
Y
D
P
K
S
V
E
P
K
W
A
E
K
W
-
A
K
N
P
F
V
A
N
P
K
--
S
--
G
--
K
P
P
F
V
I
F
M
P
-
P
P
N
V
T
G
S
L
H
M
G
H
A
L
D
N
S
L
Q
D
A
L
I
R
Y
K
R
M
R
G
F
E
A
V
W
L
P
G
T
D
H
A
G
I
A
T
Q
V
V
V
E
R
L
L
-----
L
K
---
E
-
G
K
T
R
H
D
L
G
R
E
K
F
L
E
R
V
W
Q
W
K
E
E
S
G
G
T
I
L
K
Q
L
K
R
L
G
A
S
A
D
W
S
R
E
A
F
T
M
D
E
K
R
S
R
A
V
R
Y
A
F
S
R
Y
Y
H
E
G
L
A
Y
R
A
P
R
L
V
N
W
C
P
R
C
E
T
T
L
S
D
L
E
V
--
E
------------
T
-------------------------------------------
E
P
-----------
T
P
G
K
L
-------------------------------------
Y
T
L
--------------------------------------
R
Y
E
V
E
G
G
------
G
-------
F
I
E
------
I
A
T
V
R
P
E
T
V
F
A
D
Q
A
I
A
V
-------------
H
P
E
--------------------------------------
D
E
R
---------
Y
-----------------------------------
R
--
H
L
-----------------------------------
L
--------------------
G
K
R
A
R
------------
I
-------------------------------------
P
L
T
---
E
V
W
I
P
--------
I
L
A
D
P
A
V
E
K
D
F
G
T
G
A
L
K
V
T
P
A
H
D
P
L
D
Y
E
I
G
E
R
H
G
L
K
-
P
V
S
V
I
---------------
N
L
E
G
R
M
EG
E
R
--------------
V
--
P
--
E
-------------
A
L
R
G
L
D
R
F
E
A
R
R
K
A
V
E
L
F
R
E
A
G
H
L
V
K
E
E
D
---------------
Y
T
I
A
L
A
T
C
S
R
C
G
T
P
I
E
Y
A
I
F
P
Q
W
W
L
R
M
R
P
------------
L
A
E
E
V
L
-
K
G
L
R
R
G
D
-
I
A
F
V
P
E
R
W
K
K
-
V
N
M
D
W
L
E
N
V
K
D
W
N
I
S
R
--------
Q
L
W
W
G
H
Q
I
P
A
W
Y
CEDCQAV
N
--
V
P
-
R
---------------------
P
E
R
Y
L
----------
E
------------------------
D
----------------------------
P
-------------------------
T
--
S
------------------
C
-----------
E
A
C
GSPRL
K
R
D
E
D
V
F
D
T
W
F
S
S
A
L
W
---------
P
L
S
T
L
G
W
P
-------
E
-----
E
T
E
D
L
K
A
F
Y
P
G
D
V
L
V
T
G
Y
D
------
I
L
F
L
W
V
S
R
M
E
-------
V
S
G
Y
H
F
--
M
----
G
E
R
P
F
K
T
V
L
L
H
G
L
V
-------------------------
L
D
----------------------------------------------
E
K
G
-------
Q
------------------
K
M
S
K
S
K
G
N
V
I
D
P
L
E
M
V
E
R
Y
G
A
D
A
L
R
F
A
L
I
Y
L
A
T
G
G
Q
D
I
R
L
D
L
R
W
L
-
E
M
-
A
R
N
F
A
N
K
L
Y
N
A
A
R
F
V
L
L
S
R
E
G
F
---
Q
A
K
E
D
T
P
--------
T
L
A
D
R
F
M
R
S
R
L
S
R
G
V
E
E
I
T
A
L
Y
E
A
---
L
D
L
A
Q
A
A
R
E
V
Y
E
L
V
W
S
E
F
C
D
W
Y
L
E
A
A
K
P
A
L
K
A
G
--
N
A
H
--------
T
L
R
T
L
E
E
V
L
A
V
L
L
K
L
L
H
P
M
M
P
F
L
T
S
E
L
Y
Q
A
---
L
T
-------
G
-
K
-------
E
---
E
L
A
L
E
A
W
P
E
P
G
G
--
R
D
--
E
E
A
E
R
A
F
----
E
A
L
K
Q
A
V
T
A
V
R
A
L
K
A
E
A
G
L
P
P
A
Q
E
V
R
V
Y
L
E
G
E
T
A
P
V
E
----
E
N
L
E
V
F
R
F
L
S
R
A
D
L
L
P
-----
E
R
P
A
K
A
L
V
K
A
M
P
R
V
T
A
R
M
P
L
E
G
L
L
D
V
E
E
W
R
R
R
Q
E
K
R
L
K
E
L
L
A
L
A
E
R
S
Q
R
K
L
A
S
P
G
F
R
E
K
A
P
K
E
V
V
E
A
E
E
A
R
L
K
E
N
L
E
Q
A
E
R
I
R
E
A
L
S
Q
I
G
-----
2
PsiBlast_PDB
96.66
39%
-68
- C1 -
1IVS
1
SYV_THETH
A:
[2-843]
------------
D
L
P
K
A
Y
D
P
K
S
V
E
P
K
W
A
E
K
W
-
A
K
N
P
F
V
A
N
P
K
--
S
--
G
--
K
P
P
F
V
I
F
M
P
-
P
P
N
V
T
G
S
L
H
M
G
H
A
L
D
N
S
L
Q
D
A
L
I
R
Y
K
R
M
R
G
F
E
A
V
W
L
P
G
T
D
H
A
G
I
A
T
Q
V
V
V
E
R
L
L
-----
L
K
---
E
-
G
K
T
R
H
D
L
G
R
E
K
F
L
E
R
V
W
Q
W
K
E
E
S
G
G
T
I
L
K
Q
L
K
R
L
G
A
S
A
D
W
S
R
E
A
F
T
M
D
E
K
R
S
R
A
V
R
Y
A
F
S
R
Y
Y
H
E
G
L
A
Y
R
A
P
R
L
V
N
W
C
P
R
C
E
T
T
L
S
D
L
E
V
--
E
------------
T
-------------------------------------------
E
P
-----------
T
P
G
K
L
-------------------------------------
Y
T
L
--------------------------------------
R
Y
E
V
E
G
G
------
G
-------
F
I
E
------
I
A
T
V
R
P
E
T
V
F
A
D
Q
A
I
A
V
-------------
H
P
E
--------------------------------------
D
E
R
---------
Y
-----------------------------------
R
--
H
L
-----------------------------------
L
--------------------
G
K
R
A
R
------------
I
-------------------------------------
P
L
T
---
E
V
W
I
P
--------
I
L
A
D
P
A
V
E
K
D
F
G
T
G
A
L
K
V
T
P
A
H
D
P
L
D
Y
E
I
G
E
R
H
G
L
K
-
P
V
S
V
I
---------------
N
L
E
G
R
M
E
G
E
R
--------------
V
--
P
--
E
-------------
A
L
R
G
L
D
R
F
E
A
R
R
K
A
V
E
L
F
R
E
A
G
H
L
V
K
E
E
D
---------------
Y
T
I
A
L
A
T
C
S
R
C
G
T
P
I
E
Y
A
I
F
P
Q
W
W
L
R
M
R
P
------------
L
A
E
E
V
L
-
K
G
L
R
R
G
D
-
I
A
F
V
P
E
R
W
K
K
-
V
N
M
D
W
L
E
N
V
K
D
W
N
I
S
R
--------
Q
L
W
W
G
H
Q
I
P
A
W
Y
C
EDCQ
A
V
N
--
V
P
-
R
---------------------
P
E
R
Y
L
----------
E
------------------------
D
----------------------------
P
-------------------------
T
--
S
------------------
C
-----------
E
A
C
GSP
R
L
K
R
D
E
D
V
F
D
T
W
F
S
S
A
L
W
---------
P
L
S
T
L
G
W
P
-------
E
-----
E
T
E
D
L
K
A
F
Y
P
G
D
V
L
V
T
G
Y
D
------
I
L
F
L
W
V
S
R
M
E
-------
V
S
G
Y
H
F
--
M
----
G
E
R
P
F
K
T
V
L
L
H
G
L
V
-------------------------
L
D
----------------------------------------------
E
K
G
-------
Q
------------------
K
M
S
K
S
K
G
N
V
I
D
P
L
E
M
V
E
R
Y
G
A
D
A
L
R
F
A
L
I
Y
L
A
T
G
G
Q
D
I
R
L
D
L
R
W
L
-
E
M
-
A
R
N
F
A
N
K
L
Y
N
A
A
R
F
V
L
L
S
R
E
G
F
---
Q
A
K
E
D
T
P
--------
T
L
A
D
R
F
M
R
S
R
L
S
R
G
V
E
E
I
T
A
L
Y
E
A
---
L
D
L
A
Q
A
A
R
E
V
Y
E
L
V
W
S
E
F
C
D
W
Y
L
E
A
A
K
P
A
L
K
A
G
--
N
A
H
--------
T
L
R
T
L
E
E
V
L
A
V
L
L
K
L
L
H
P
M
M
P
F
L
T
S
E
L
Y
Q
A
---
L
T
-------
G
-
K
-------
E
---
E
L
A
L
E
A
W
P
E
P
G
G
--
R
D
--
E
E
A
E
R
A
F
----
E
A
L
K
Q
A
V
T
A
V
R
A
L
K
A
E
A
G
L
P
P
A
Q
E
V
R
V
Y
L
E
G
E
T
A
P
V
E
----
E
N
L
E
V
F
R
F
L
S
R
A
D
L
L
P
-----
E
R
P
A
K
A
L
V
K
A
M
P
R
V
T
A
R
M
P
L
E
G
L
L
D
V
E
E
W
R
R
R
Q
E
K
R
L
K
E
L
L
A
L
A
E
R
S
Q
R
K
L
A
S
P
G
F
R
E
K
A
P
K
E
V
V
E
A
E
E
A
R
L
K
E
N
L
E
Q
A
E
R
I
R
E
A
L
S
Q
I
G
-----
22
PsiBlast_CBE
96.64
39%
-65
- C1 -
1GAX
3
SYV_THETH
B:
[2-843]
------------
D
L
P
K
A
Y
D
P
K
S
V
E
P
K
W
A
E
K
W
-
A
K
N
P
F
V
A
N
P
K
--
S
--
G
--
K
P
P
F
V
I
F
M
P
-
P
P
N
V
T
G
S
L
H
M
G
H
A
L
D
N
S
L
Q
D
A
L
I
R
Y
K
R
M
R
G
F
E
A
V
W
L
P
G
T
D
H
A
G
I
A
T
Q
V
V
V
E
R
L
L
-----
L
K
---
E
-
G
K
T
R
H
D
L
G
R
E
K
F
L
E
R
V
W
Q
W
K
E
E
S
G
G
T
I
L
K
Q
L
K
R
L
G
A
S
A
D
W
S
R
E
A
F
T
M
D
E
K
R
S
R
A
V
R
Y
A
F
S
R
Y
Y
H
E
G
L
A
Y
R
A
P
R
L
V
N
W
C
P
R
C
E
T
T
L
S
D
L
E
V
--
E
------------
T
-------------------------------------------
E
P
-----------
T
P
G
K
L
-------------------------------------
Y
T
L
--------------------------------------
R
Y
E
V
E
G
G
------
G
-------
F
I
E
------
I
A
T
V
R
P
E
T
V
F
A
D
Q
A
I
A
V
-------------
H
P
E
--------------------------------------
D
E
R
---------
Y
-----------------------------------
R
--
H
L
-----------------------------------
L
--------------------
G
K
R
A
R
------------
I
-------------------------------------
P
L
T
---
E
V
W
I
P
--------
I
L
A
D
P
A
V
E
K
D
F
G
T
G
A
L
K
V
T
P
A
H
D
P
L
D
Y
E
I
G
E
R
H
G
L
K
-
P
V
S
V
I
---------------
N
L
E
G
R
M
EG
E
R
--------------
V
--
P
--
E
-------------
A
L
R
G
L
D
R
F
E
A
R
R
K
A
V
E
L
F
R
E
A
G
H
L
V
K
E
E
D
---------------
Y
T
I
A
L
A
T
C
S
R
C
G
T
P
I
E
Y
A
I
F
P
Q
W
W
L
R
M
R
P
------------
L
A
E
E
V
L
-
K
G
L
R
R
G
D
-
I
A
F
V
P
E
R
W
K
K
-
V
N
M
D
W
L
E
N
V
K
D
W
N
I
S
R
--------
Q
L
W
W
G
H
Q
I
P
A
W
Y
CEDCQAV
N
--
V
P
-
R
---------------------
P
E
R
Y
L
----------
E
------------------------
D
----------------------------
P
-------------------------
T
--
S
------------------
C
-----------
E
A
C
GSPRL
K
R
D
E
D
V
F
D
T
W
F
S
S
A
L
W
---------
P
L
S
T
L
G
W
P
-------
E
-----
E
T
E
D
L
K
A
F
Y
P
G
D
V
L
V
T
G
Y
D
------
I
L
F
L
W
V
S
R
M
E
-------
V
S
G
Y
H
F
--
M
----
G
E
R
P
F
K
T
V
L
L
H
G
L
V
-------------------------
L
D
----------------------------------------------
E
K
G
-------
Q
------------------
K
M
S
K
S
K
G
N
V
I
D
P
L
E
M
V
E
R
Y
G
A
D
A
L
R
F
A
L
I
Y
L
A
T
G
G
Q
D
I
R
L
D
L
R
W
L
-
E
M
-
A
R
N
F
A
N
K
L
Y
N
A
A
R
F
V
L
L
S
R
E
G
F
---
Q
A
K
E
D
T
P
--------
T
L
A
D
R
F
M
R
S
R
L
S
R
G
V
E
E
I
T
A
L
Y
E
A
---
L
D
L
A
Q
A
A
R
E
V
Y
E
L
V
W
S
E
F
C
D
W
Y
L
E
A
A
K
P
A
L
K
A
G
--
N
A
H
--------
T
L
R
T
L
E
E
V
L
A
V
L
L
K
L
L
H
P
M
M
P
F
L
T
S
E
L
Y
Q
A
---
L
T
-------
G
-
K
-------
E
---
E
L
A
L
E
A
W
P
E
P
G
G
--
R
D
--
E
E
A
E
R
A
F
----
E
A
L
K
Q
A
V
T
A
V
R
A
L
K
A
E
A
G
L
P
P
A
Q
E
V
R
V
Y
L
E
G
E
T
A
P
V
E
----
E
N
L
E
V
F
R
F
L
S
R
A
D
L
L
P
-----
E
R
P
A
K
A
L
V
K
A
M
P
R
V
T
A
R
M
P
L
E
G
L
L
D
V
E
E
W
R
R
R
Q
E
K
R
L
K
E
L
L
A
L
A
E
R
S
Q
R
K
L
A
S
P
G
F
R
E
K
A
P
K
E
V
V
E
A
E
E
A
R
L
K
E
N
L
E
Q
A
E
R
I
R
E
A
L
S
Q
I
G
-----
1
PsiBlast_PDB
95.93
39%
-65
* C1 *
1GAX
3
SYV_THETH
A:
[2-843]
------------
D
L
P
K
A
Y
D
P
K
S
V
E
P
K
W
A
E
K
W
-
A
K
N
P
F
V
A
N
P
K
--
S
--
G
--
K
P
P
F
V
I
F
M
P
-
P
P
N
V
T
G
S
L
H
M
G
H
A
L
D
N
S
L
Q
D
A
L
I
R
Y
K
R
M
R
G
F
E
A
V
W
L
P
G
T
D
H
A
G
I
A
T
Q
V
V
V
E
R
L
L
-----
L
K
---
E
-
G
K
T
R
H
D
L
G
R
E
K
F
L
E
R
V
W
Q
W
K
E
E
S
G
G
T
I
L
K
Q
L
K
R
L
G
A
S
A
D
W
S
R
E
A
F
T
M
D
E
K
R
S
R
A
V
R
Y
A
F
S
R
Y
Y
H
E
G
L
A
Y
R
A
P
R
L
V
N
W
C
P
R
C
E
T
T
L
S
D
L
E
V
--
E
------------
T
-------------------------------------------
E
P
-----------
T
P
G
K
L
-------------------------------------
Y
T
L
--------------------------------------
R
Y
E
V
E
G
G
------
G
-------
F
I
E
------
I
A
T
V
R
P
E
T
V
F
A
D
Q
A
I
A
V
-------------
H
P
E
--------------------------------------
D
E
R
---------
Y
-----------------------------------
R
--
H
L
-----------------------------------
L
--------------------
G
K
R
A
R
------------
I
-------------------------------------
P
L
T
---
E
V
W
I
P
--------
I
L
A
D
P
A
V
E
K
D
F
G
T
G
A
L
K
V
T
P
A
H
D
P
L
D
Y
E
I
G
E
R
H
G
L
K
-
P
V
S
V
I
---------------
N
L
E
G
R
M
E
G
E
R
--------------
V
--
P
--
E
-------------
A
L
R
G
L
D
R
F
E
A
R
R
K
A
V
E
L
F
R
E
A
G
H
L
V
K
E
E
D
---------------
Y
T
I
A
L
A
T
C
S
R
C
G
T
P
I
E
Y
A
I
F
P
Q
W
W
L
R
M
R
P
------------
L
A
E
E
V
L
-
K
G
L
R
R
G
D
-
I
A
F
V
P
E
R
W
K
K
-
V
N
M
D
W
L
E
N
V
K
D
W
N
I
S
R
--------
Q
L
W
W
G
H
Q
I
P
A
W
Y
C
EDCQ
A
V
N
--
V
P
-
R
---------------------
P
E
R
Y
L
----------
E
------------------------
D
----------------------------
P
-------------------------
T
--
S
------------------
C
-----------
E
A
C
GSPRL
K
R
D
E
D
V
F
D
T
W
F
S
S
A
L
W
---------
P
L
S
T
L
G
W
P
-------
E
-----
E
T
E
D
L
K
A
F
Y
P
G
D
V
L
V
T
G
Y
D
------
I
L
F
L
W
V
S
R
M
E
-------
V
S
G
Y
H
F
--
M
----
G
E
R
P
F
K
T
V
L
L
H
G
L
V
-------------------------
L
D
----------------------------------------------
E
K
G
-------
Q
------------------
K
M
S
K
S
K
G
N
V
I
D
P
L
E
M
V
E
R
Y
G
A
D
A
L
R
F
A
L
I
Y
L
A
T
G
G
Q
D
I
R
L
D
L
R
W
L
-
E
M
-
A
R
N
F
A
N
K
L
Y
N
A
A
R
F
V
L
L
S
R
E
G
F
---
Q
A
K
E
D
T
P
--------
T
L
A
D
R
F
M
R
S
R
L
S
R
G
V
E
E
I
T
A
L
Y
E
A
---
L
D
L
A
Q
A
A
R
E
V
Y
E
L
V
W
S
E
F
C
D
W
Y
L
E
A
A
K
P
A
L
K
A
G
--
N
A
H
--------
T
L
R
T
L
E
E
V
L
A
V
L
L
K
L
L
H
P
M
M
P
F
L
T
S
E
L
Y
Q
A
---
L
T
-------
G
-
K
-------
E
---
E
L
A
L
E
A
W
P
E
P
G
G
--
R
D
--
E
E
A
E
R
A
F
----
E
A
L
K
Q
A
V
T
A
V
R
A
L
K
A
E
A
G
L
P
P
A
Q
E
V
R
V
Y
L
E
G
E
T
A
P
V
E
----
E
N
L
E
V
F
R
F
L
S
R
A
D
L
L
P
-----
E
R
P
A
K
A
L
V
K
A
M
P
R
V
T
A
R
M
P
L
E
G
L
L
D
V
E
E
W
R
R
R
Q
E
K
R
L
K
E
L
L
A
L
A
E
R
S
Q
R
K
L
A
S
P
G
F
R
E
K
A
P
K
E
V
V
E
A
E
E
A
R
L
K
E
N
L
E
Q
A
E
R
I
R
E
A
L
S
Q
I
G
-----
81
HHSearch
82.36
25%
-65
- C1 -
1ILE
2
SYI_THET8
A:
[4-821]
-------------
E
V
G
E
P
N
F
P
K
L
E
E
E
V
L
A
F
W
K
R
E
K
I
F
Q
K
S
V
E
--
N
R
K
G
--
G
P
R
Y
T
V
Y
E
G
-
P
P
T
A
N
G
L
P
H
V
G
H
A
Q
A
R
S
Y
K
D
L
F
P
R
Y
K
T
M
R
G
Y
Y
A
P
R
R
A
G
W
D
T
H
G
L
P
V
E
L
E
V
E
K
K
L
-----
G
L
---
K
S
K
R
E
I
E
A
Y
G
I
E
R
F
N
Q
A
C
R
E
S
V
F
T
Y
E
K
E
W
E
A
F
T
E
R
I
A
Y
W
V
D
L
E
D
A
Y
A
T
L
E
P
T
Y
I
E
S
I
W
W
S
L
K
N
L
F
D
R
G
L
L
Y
R
D
H
K
V
V
P
Y
C
P
R
C
G
T
P
L
S
S
H
E
V
A
L
G
------------
Y
-------------------------------------------
K
E
-----------
I
Q
D
P
S
-------------------------------------
V
Y
V
--------------------------------------
R
F
P
L
K
E
P
KKLGLE
K
A
------
S
L
L
------
I
W
T
T
T
P
W
T
L
P
G
N
V
A
A
A
V
-------------
H
P
E
--------------------------------------
Y
T
Y
---------
A
A
F
Q
V
GD
E
A
L
I
L
EE
G
L
G
R
K
LLGEGTQV
L
K
T
F
P
G---
K
--
A
L
-----------------------------------
E
--------------------
G
L
P
Y
T
------------
P
-------------------------------------
P
Y
P
QAL
E
K
G
Y
F
--------
V
V
L
A
D
Y
V
S
Q
E
D
G
T
G
I
V
H
Q
A
P
A
F
G
A
E
D
L
E
T
A
R
V
Y
G
L
P
-
L
L
K
T
V
---------------
D
E
E
G
K
L
--
L
------------------
V
--
E
-------------
P
F
K
G
L
Y
F
R
E
A
N
R
A
I
L
R
D
L
R
G
R
G
L
L
F
K
E
E
S
---------------
Y
L
H
S
Y
P
H
C
W
R
C
S
T
P
L
M
Y
Y
A
T
E
S
W
F
I
K
N
T
L
------------
F
K
D
E
L
I
-
R
N
N
Q
---
E
I
H
W
V
P
P
H
I
K
E
G
R
Y
G
E
W
L
K
N
L
V
D
W
A
L
S
R
--------
N
R
Y
W
G
T
P
L
P
I
W
V
-------
C
--
Q
A
C
G
---------------------
K
E
E
A
I
----------
G
------------------------
S
F
Q
E
L
K
A
R
ATKPLPEPFDPHR
P
Y
V
D
Q
V
E
L
A
-------------------------
C
A-
C
------------------
G
-----------
G
T
M
-----
R
R
V
P
Y
V
I
D
V
W
Y
D
S
G
A
M
---------
P
F
A
S
L
H
Y
P
-------
F
E
----
H
E
E
V
F
R
E
S
F
P
A
D
F
I
A
E
G
I
D
------
Q
T
R
G
W
F
N
S
L
H
-------
Q
L
G
V
M
L
--
F
----
G
S
I
A
F
K
N
V
I
C
H
G
L
I
-------------------------
L
D
----------------------------------------------
E
K
G
-------
Q
------------------
K
M
S
K
S
K
G
N
V
V
D
P
W
D
I
I
R
K
F
G
A
D
A
L
R
W
Y
I
Y
V
S
A
P
P
E
A
D
R
R
F
G
P
N
L
V
-
R
E
T
V
R
D
Y
F
L
T
L
W
N
V
Y
S
F
F
V
T
Y
A
N
L
D
R
P
D
L
K
-----
N
P
P
P
P
E
K
R
P
E
M
D
R
W
L
L
A
R
M
Q
D
L
I
Q
R
V
T
E
A
L
E
A
---
Y
D
P
T
T
S
A
R
A
L
R
D
F
V
V
E
D
L
S
Q
W
Y
V
R
R
N
R
R
R
F
W
K
N
--
E
D
A
L-
D
R
E
--
A
A
Y
A
T
L
Y
E
A
L
V
L
V
A
T
L
A
A
P
F
T
P
F
L
A
E
V
L
W
-
Q
---
N
L
-------
V
-
R
SVRLEAK
E
---
S
V
H
L
A
D
W
P
E
A
D
P
A
L
A
D
--
E
A
L
V
A
Q
M
----
R
A
V
L
K
V
V
D
L
A
R
A
A
R
A
K
S
G
V
------------------------------------------------------------------------------------------------------------------------------------------
80
HHSearch
82.08
27%
-61
- C1 -
1FFY
4
SYI1_STAAU
A:
[12-863]
-----------
T
D
F
P
M
R
G
G
L
P
N
K
E
P
Q
I
Q
E
K
W
D
A
E
D
Q
Y
H
K
A
L
E
--
K
N
K
G
--
N
E
T
F
I
L
H
D
G
-
P
P
Y
A
N
G
N
L
H
M
G
H
A
L
N
K
I
L
K
D
F
I
V
R
Y
K
T
M
Q
G
F
Y
A
P
Y
V
P
G
W
D
T
H
G
L
P
I
E
Q
A
L
T
K
K
-------------
G
V
D
R
K
K
M
S
T
A
E
F
R
E
K
C
K
E
F
A
L
E
Q
I
E
L
Q
K
K
D
F
R
R
L
G
V
R
G
D
F
N
D
P
Y
I
T
L
K
P
E
Y
E
A
A
Q
I
R
I
F
G
E
M
A
D
K
G
L
I
Y
K
G
K
K
P
V
Y
W
S
P
S
S
E
S
S
L
A
E
A
E
I
--
E
------------
Y
-------------------------------------------
H
D
-----------
K
R
S
A
S
-------------------------------------
I
Y
V
--------------------------------------
A
F
N
V
K
D
D
KGVVDA
D
A
------
K
F
I
------
I
W
T
T
T
P
W
T
I
P
S
N
V
A
I
T
V
-------------
H
P
E
--------------------------------------
L
K
Y
GQYNVNGEK
Y
I
I
A
E
ALSDAVAEALDWDKAS
I
K
L
E
KEYTG------
K
--
E
L
-----------------------------------
E
--------------------
W
V
V
A
Q
------------
H
-------------------------------------
P
F
L
---
D
R
E
S
L
--------
V
I
N
G
D
H
V
T
T
D
A
G
T
G
C
V
H
T
A
P
G
H
G
E
D
D
Y
I
V
G
Q
Q
Y
E
L
P
-
V
I
S
P
I
---------------
D
D
K
G
V
F
--
T
E
--------------
E
--
G
--
G
-------------
Q
F
E
G
M
F
Y
D
K
A
N
K
A
V
T
D
L
L
T
E
K
G
A
L
L
K
L
D
F
---------------
I
T
H
S
Y
P
H
D
W
R
T
K
K
P
V
I
F
R
A
T
P
Q
W
F
A
S
I
S
K
------------
V
R
Q
D
I
L
-
D
A
I
E
---
N
T
N
F
K
V
N
W
G
K
T
-
R
I
Y
N
M
V
R
D
R
G
E
W
V
I
S
R
--------
Q
R
V
W
G
V
P
L
P
V
F
Y
-------
A
--
E
N
-
G
---------------------
E
I
I
M
T
----------
K
E
T
V
N
H
V
A
D
L
F
A
E
HGS
N
I
W
F
E
R
EAK
D
LLPEGFTHP-------------------
G
-------------------------
S
--
P
------------------
N
-----------
G
T
F
-----
T
K
E
T
D
I
M
D
V
W
F
D
S
G
S
S
---------
H
R
G
V
L
E
T
R
-----------------
P
E
L
S
F
P
A
D
M
Y
L
E
G
S
D
------
Q
Y
R
G
W
F
N
S
S
I
-------
T
T
S
V
A
T
--
R
----
G
V
S
P
Y
K
F
L
L
S
H
G
F
V
-------------------------
M
D
----------------------------------------------
G
E
G
-------
K
------------------
K
M
S
K
S
L
G
N
V
I
V
P
D
Q
V
V
K
Q
K
G
A
D
I
A
R
L
W
V
S
S
T
-
D
Y
L
A
D
V
R
I
S
D
E
I
L
-
K
Q
-
T
S
D
D
Y
R
K
I
R
N
T
L
R
F
M
L
G
N
I
N
D
F
N
P
D
T
D
------
S
I
P
E
S
E
L
L
E
V
D
R
Y
L
L
N
R
L
R
E
F
T
A
S
T
I
N
N
Y
E
N
---
F
D
Y
L
N
I
Y
Q
E
V
Q
N
F
I
N
V
E
L
S
N
F
Y
L
D
Y
G
K
D
I
L
Y
I
E
--
Q
R
D
S
H
I
R
R
--
S
M
Q
T
V
L
Y
Q
I
L
V
D
M
T
K
L
L
A
P
I
L
V
H
T
A
E
E
V
W
-
S
---
H
T
-------
P
-
H
-------
V
KEE
S
V
H
L
A
D
M
P
K
V
V
E
--
V
D
--
Q
A
L
L
D
K
W
R
T
F
M
N
L
R
D
D
V
N
R
A
L
E
T
A
R
N
E
K
V
I
G
K
S
L
E
A
K
V
T
I
A
S
N
D
K
F
N
A
S
E
F
L
T
S
F
D
A
L
H
Q
L
F
I
V
S
Q
V
K
V
V
D
K
L
D
D
Q
A
T
A
Y
E
H
G
D
I
V
I
E
H
A
D
G
E
K
C
E
R
C
W
N
Y
S
E
D
L
G
A
V
D
E
L
T
H
L
C
P
R
C
Q
Q
V
V
K
S
L
V
------------------------------------------
7
PsiBlast_PDB
81.78
24%
-67
- C1 -
1JZQ
3
SYI_THET8
A:
[9-821]
------------------
N
F
P
K
L
E
E
E
V
L
A
F
W
K
R
E
K
I
F
Q
K
S
V
E
--
N
--
R
KG
G
P
R
Y
T
V
Y
E
G
-
P
P
T
A
N
G
L
P
H
V
G
H
A
Q
A
R
S
Y
K
D
L
F
P
R
Y
K
T
M
R
G
Y
Y
A
P
R
R
A
G
W
D
T
H
G
L
P
V
E
L
E
V
E
K
K
L
GLKS
K
R
E
I
E
A
Y
-
G
I
E
R
F
N
---
Q
A
C
R
E
S
V
F
T
Y
E
K
E
W
E
A
F
T
E
----
R
I
A
Y
W
V
D
L
E
D
A
Y
A
T
L
E
P
T
Y
I
E
S
I
W
W
S
L
K
N
L
F
D
R
G
L
L
Y
R
D
H
K
V
V
P
Y
C
P
R
C
G
T
P
L
S
S
H
E
V
--
A
L
G
----------
Y
-------------------------------------------
K
E
-----------
I
Q
D
P
S
-------------------------------------
V
Y
V
--------------------------------------
R
F
P
L
K
E
P
------
K
K
LGLE
K
A
S
L
L
------
I
W
T
T
T
P
W
T
L
P
G
N
V
A
A
A
V
-------------
H
P
E
Y
T
Y
A
A
F
Q
V
GD
E
A
L
I
L
E----------------------
E
G
L
---------
G
-----------------------------------
R
--
K
L
-----------------------------------
L
--------------------
G
E
G
T
Q
VL
K
T
F
P
GKALEG
L
-------------------------------------
P
Y
----
T
P
P
Y
P
QALEKGY
F
V
V
L
A
D
Y
V
S
Q
E
D
G
T
G
I
V
H
Q
A
P
A
F
G
A
E
D
L
E
T
A
R
V
Y
G
L
P
-
L
L
K
T
V
---------------
D
E
E
G
K
L
------------------
L
--
V
--
E
-------------
P
F
K
G
L
Y
F
R
E
A
N
R
A
I
L
R
D
L
R
G
R
G
L
L
F
K
E
E
S
---------------
Y
L
H
S
Y
P
H
C
W
R
C
S
T
P
L
M
Y
Y
A
T
E
S
W
F
I
K
-
N
T
------------
L
F
K
D
E
L
-
I
R
N
N
Q
E
--
I
H
W
V
P
P
H
I
K
E
G
R
Y
G
E
W
L
K
N
L
V
D
W
A
L
S
R
--------
N
R
Y
W
G
T
P
L
P
I
W
V
-------
C
QA
C
G
-
K
---------------------
E
E
A
I
G
S
F
Q
E
L
K
A
R
AT
K
------------------------
P
----------------------------
L
-------------------------
P
--
E
PFDPHR
P
Y
V
D
Q
V
E
L
A
C
AC
G
-----------
G
T
M
-----
R
R
V
P
Y
V
I
D
V
W
Y
D
S
G
A
M
---------
P
F
A
S
L
H
Y
P
-------
F
E
----
H
E
E
V
F
R
E
S
F
P
A
D
F
I
A
E
G
I
D
------
Q
T
R
G
W
F
N
S
L
H
-------
Q
L
G
V
M
L
--
F
----
G
S
I
A
F
K
N
V
I
C
H
G
L
I
-------------------------
L
D
----------------------------------------------
E
K
G
-------
Q
------------------
K
M
S
K
S
K
G
N
V
V
D
P
W
D
I
I
R
K
F
G
A
D
A
L
R
W
Y
I
Y
V
S
A
P
P
E
A
D
R
R
F
G
P
N
L
V
R
E
T
-
V
R
D
Y
F
L
T
L
W
N
V
Y
S
F
F
V
T
Y
A
---
N
L
D
--
R
P
D
L
K
N
P
P
P
P
E
K
R
P
E
M
D
R
W
L
L
A
R
M
Q
D
L
I
Q
R
V
T
E
A
L
E
A
---
Y
D
P
T
T
S
A
R
A
L
R
D
F
V
V
E
D
L
S
Q
W
Y
V
R
R
N
R
R
R
F
W
K
---
N
E
D
A
L
D
R
E
--
A
A
Y
A
T
L
Y
E
A
L
V
L
V
A
T
L
A
A
P
F
T
P
F
L
A
E
V
L
W
-
Q
---
N
L
VRSVRLE
A
-
K
-------
E
---
S
V
H
L
A
D
W
P
E
A
D
P
A
L
A
D
--
E
A
L
V
A
Q
M
----
R
A
V
L
K
V
V
D
L
A
R
A
A
R
A
K
S
G
V
------------------------------------------------------------------------------------------------------------------------------------------
8
PsiBlast_PDB
81.35
24%
-67
- C1 -
1JZS
3
SYI_THET8
A:
[9-821]
------------------
N
F
P
K
L
E
E
E
V
L
A
F
W
K
R
E
K
I
F
Q
K
S
V
E
--
N
--
R
KG
G
P
R
Y
T
V
Y
E
G
-
P
P
T
A
N
G
L
P
H
V
G
H
A
Q
A
R
S
Y
K
D
L
F
P
R
Y
K
T
M
R
G
Y
Y
A
P
R
R
A
G
W
D
T
H
G
L
P
V
E
L
E
V
E
K
K
L
GLKS
K
R
E
I
E
A
Y
-
G
I
E
R
F
N
---
Q
A
C
R
E
S
V
F
T
Y
E
K
E
W
E
A
F
T
E
----
R
I
A
Y
W
V
D
L
E
D
A
Y
A
T
L
E
P
T
Y
I
E
S
I
W
W
S
L
K
N
L
F
D
R
G
L
L
Y
R
D
H
K
V
V
P
Y
C
P
R
C
G
T
P
L
S
S
H
E
V
--
A
L
G
----------
Y
-------------------------------------------
K
E
-----------
I
Q
D
P
S
-------------------------------------
V
Y
V
--------------------------------------
R
F
P
L
K
E
P
------
K
K
LGLE
K
A
S
L
L
------
I
W
T
T
T
P
W
T
L
P
G
N
V
A
A
A
V
-------------
H
P
E
Y
T
Y
A
AFQVGD
E
A
L
I
L
E
----------------------
E
G
L
---------
G
-----------------------------------
R
--
K
L
-----------------------------------
L
--------------------
G
E
G
T
Q
VL
K
T
F
P
GKALEG
L
-------------------------------------
P
Y
----
T
P
P
Y
P
QALEKGY
F
V
V
L
A
D
Y
V
S
Q
E
D
G
T
G
I
V
H
Q
A
P
A
F
G
A
E
D
L
E
T
A
R
V
Y
G
L
P
-
L
L
K
T
V
---------------
D
E
E
G
K
L
------------------
L
--
V
--
E
-------------
P
F
K
G
L
Y
F
R
E
A
N
R
A
I
L
R
D
L
R
G
R
G
L
L
F
K
E
E
S
---------------
Y
L
H
S
Y
P
H
C
W
R
C
S
T
P
L
M
Y
Y
A
T
E
S
W
F
I
K
-
N
T
------------
L
F
K
D
E
L
-
I
R
N
N
Q
E
--
I
H
W
V
P
P
H
I
K
E
G
R
Y
G
E
W
L
K
N
L
V
D
W
A
L
S
R
--------
N
R
Y
W
G
T
P
L
P
I
W
V
-------
C
QA
C
G
-
K
---------------------
E
E
A
I
G
S
F
Q
E
L
K
A
R
AT
K
------------------------
P
----------------------------
L
-------------------------
P
--
E
PFDPH
R
P
Y
V
D
Q
V
E
L
A
C
AC
G
-----------
G
T
M
-----
R
R
V
P
Y
V
I
D
V
W
Y
D
S
G
A
M
---------
P
F
A
S
L
H
Y
P
-------
F
E
----
H
E
E
V
F
R
E
S
F
P
A
D
F
I
A
E
G
I
D
------
Q
T
R
G
W
F
N
S
L
H
-------
Q
L
G
V
M
L
--
F
----
G
S
I
A
F
K
N
V
I
C
H
G
L
I
-------------------------
L
D
----------------------------------------------
E
K
G
-------
Q
------------------
K
M
S
K
S
K
G
N
V
V
D
P
W
D
I
I
R
K
F
G
A
D
A
L
R
W
Y
I
Y
V
S
A
P
P
E
A
D
R
R
F
G
P
N
L
V
R
E
T
-
V
R
D
Y
F
L
T
L
W
N
V
Y
S
F
F
V
T
Y
A
---
N
L
D
--
R
P
D
L
K
N
P
P
P
P
E
K
R
P
E
M
D
R
W
L
L
A
R
M
Q
D
L
I
Q
R
V
T
E
A
L
E
A
---
Y
D
P
T
T
S
A
R
A
L
R
D
F
V
V
E
D
L
S
Q
W
Y
V
R
R
N
R
R
R
F
W
K
---
N
E
D
A
L
D
R
E
--
A
A
Y
A
T
L
Y
E
A
L
V
L
V
A
T
L
A
A
P
F
T
P
F
L
A
E
V
L
W
-
Q
---
N
L
VRSVRLE
A
-
K
-------
E
---
S
V
H
L
A
D
W
P
E
A
D
P
A
L
A
D
--
E
A
L
V
A
Q
M
----
R
A
V
L
K
V
V
D
L
A
R
A
A
R
A
K
S
G
V
------------------------------------------------------------------------------------------------------------------------------------------
104
Fugue
81.34
25%
-52
- C1 -
1QU2
5
SYI1_STAAU
A:
[1-917]
MDYEKTLLM
P
K
T
D
F
P
M
R
G
G
L
P
N
K
E
P
Q
I
Q
E
K
W
D
A
E
D
Q
Y
H
K
A
L
E
K
N
K
--
G
--
N
E
T
F
I
L
H
D
G
-
P
P
Y
A
N
G
N
L
H
M
G
H
A
L
N
K
I
L
K
D
F
I
V
R
Y
K
T
M
Q
G
F
Y
A
P
Y
V
P
G
W
D
T
H
G
----
L
P
I
E
Q
A
L
-----
T
K
---
K
-
G
V
D
R
K
K
M
S
T
A
E
F
R
E
K
C
K
E
F
A
L
E
Q
I
E
L
Q
K
K
D
F
R
R
L
G
V
R
G
D
F
N
D
P
Y
I
T
L
K
P
E
Y
E
A
A
Q
I
R
I
F
G
E
M
A
D
K
G
L
I
Y
K
G
K
K
P
V
Y
W
S
P
S
S
E
S
S
L
A
E
A
E
I
--
E
------------
Y
-------------------------------------------
H
D
-----------
K
R
S
A
S
-------------------------------------
I
Y
V
--------------------------------------
A
F
N
V
K
D
D
------
K
G
------
V
V
D
AD
A
K
F
I
I
W
T
T
T
P
W
T
I
P
S
N
V
A
I
T
V
-------------
H
P
E
LKYGQYNVNGEK
Y
I
I
A
E
ALSDAVAEALDWDKAS
I
K
L
E
K
E
Y
T
---------
G
-----------------------------------
K
--
E
L
-----------------------------------
E
--------------------
W
V
V
A
Q
------------
H
-------------------------------------
P
F
L
---
D
R
E
S
L
--------
V
I
N
G
D
H
V
T
T
D
A
G
T
G
C
V
H
T
A
P
G
H
G
E
D
D
Y
I
V
G
Q
Q
Y
E
L
P
-
V
I
S
P
I
---------------
D
D
K
G
V
F
--
T
E
--------------
E
--
G
--
G
-------------
Q
F
E
G
M
F
Y
D
K
A
N
K
A
V
T
D
L
L
T
E
K
G
A
L
L
K
L
D
F
---------------
I
T
H
S
Y
P
H
D
W
R
T
K
K
P
V
I
F
R
A
T
P
Q
W
F
A
S
I
S
K
------------
V
R
Q
D
I
L
-
D
A
I
E
---
N
T
N
F
K
V
N
W
G
K
T
-
R
I
Y
N
M
V
R
D
R
G
E
W
V
I
S
R
--------
Q
R
V
W
G
V
P
L
P
V
F
Y
-------
A
--
E
N
-
G
E
I
I
M
T
K
E
T
V
N
H
V
A
D
L
F
A
E
HGS
N
I
W
F
E
----------
R
------------------------
E
----------------------------
A
-------------------------
K
--
D
LLPEGFTHPGSP------
N
-----------
G
T
F
-----
T
K
E
T
D
I
M
D
V
W
F
D
S
G
S
S
---------
H
R
G
V
L
E
T
R
-------
P
----------
E
L
S
F
P
A
D
M
Y
L
E
G
S
D
------
Q
Y
R
G
W
F
N
S
S
I
-------
T
T
S
V
A
T
--
R
----
G
V
S
P
Y
K
F
L
L
S
H
G
F
V
-------------------------
M
D
----------------------------------------------
G
E
G
-------
K
------------------
K
M
S
K
S
L
G
N
V
I
V
P
D
Q
V
V
K
Q
K
G
A
D
I
A
R
L
W
V
S
S
-
T
D
Y
L
A
D
V
R
I
S
D
E
I
L
-
K
Q
-
T
S
D
D
Y
R
K
I
R
N
T
L
R
F
M
L
G
N
I
N
D
F
N
P
D
T
D
S
I
P
E
S
E
L
------
L
E
V
D
R
Y
L
L
N
R
L
R
E
F
T
A
S
T
I
N
N
Y
E
N
---
F
D
Y
L
N
I
Y
Q
E
V
Q
N
F
I
N
V
E
L
S
N
F
Y
L
D
Y
G
K
D
I
L
Y
I
E
QR
D
S
H
--
I
R
R
--
S
M
Q
T
V
L
Y
Q
I
L
V
D
M
T
K
L
L
A
P
I
L
V
H
T
A
E
E
V
W
-
S
---
H
T
PHV----
K
-
E
-------
E
---
S
V
H
L
A
D
M
P
K
V
V
E
V
D
Q
A
L
L
D
K
W
R
T
F
M
----
N
L
R
D
D
V
N
R
A
L
E
T
A
R
N
E
K
V
I
G
K
S
L
E
A
K
V
T
I
A
S
N
D
K
F
N
A
S
E
F
L
T
S
F
D
A
L
H
Q
L
F
I
V
S
Q
V
K
V
V
D
K
L
D
D
Q
----
A
T
A
Y
E
H
G
D
I
V
I
E
H
A
D
----
G
E
K
C
E
R
C
W
N
Y
S
E
D
L
G
A
V
---------------------------------
D
E
L
T
H
L
C
P
R
C
Q
Q
V
V
K
S
L
V
-
84
HHSearch
80.87
24%
-70
- C1 -
2V0C
10
?
A:
[2-813]
---------------
E
K
Y
N
P
H
A
I
E
A
K
W
Q
R
F
W
E
E
K
G
F
M
K
A
K
D
L
--
P
G------
K
Q
Y
V
L
V
M
-
F
P
Y
P
S
G
D
L
H
M
G
H
L
K
N
Y
T
M
G
D
V
L
A
R
F
R
R
M
Q
G
Y
E
V
L
H
P
M
G
W
D
A
F
G
L
P
A
E
N
A
A
L
K
F
-------------
G
V
------------
H
P
K
D
W
T
Y
A
N
I
R
Q
A
K
E
S
L
R
L
M
G
I
L
Y
D
W
D
R
E
V
T
T
C
E
P
E
Y
Y
R
W
N
Q
W
I
F
L
K
M
W
E
K
G
L
A
Y
R
A
K
G
L
V
N
W
C
P
K
C
Q
T
V
L
A
N
E
Q
V
--
V
------------
E
-------------------------------------------
G
R
CWRHED
T
P
V
E
K
R
E
L
E
Q
-------------------------------------
W
Y
L
RITAY
A
E
R
L
L
K
D
LEGLNWP
E
K
V
K
A
M
Q
R
A
W
I
G
R
S
E
G
A
E
I
L
F
P
V
E
G
K
------
E
V
------
R
I
P
------
V
F
T
T
R
P
D
T
L
F
G
A
T
F
L
V
L
-------------
A
P
E
--------------------------------------
H
P
L
---------
T
LELAAPEK
R
E
E
V
L
A
Y
V
E
A
A
K
R
KT
E
I
E
R
Q
AEGRE
K
T
G
--
V
F
-----------------------------------
L
--------------------
G
A
Y
A
L
------------
N
-------------------------------------
P
A
T
---
G
E
R
I
P
--------
I
W
T
A
D
Y
V
L
F
G
Y
G
T
G
A
I
M
A
V
P
A
H
D
Q
R
D
Y
E
F
A
R
K
F
G
L
P
-
I
K
K
V
I
---------------
E
R
P
G
E
P
--
L
P
EPLERAYE
E
P
G
I
M
V
N
--
S
--
G
-------------
P
F
D
G
T
E
S
E
E
G
K
R
K
V
I
A
W
L
E
E
K
G
L
G
K
------------------------------------------------------------------------------------
G
-
R
---
V
T
Y
R
L
R
D
W
L
I
S
R
--------
Q
R
Y
W
G
T
P
I
P
M
V
H
-------
C
--
E
A
C
G
---------------------
V
V
P
V
P
----------
E
EELPVLLPDLKDVEDIRPKGK---
S
PLEAHPEFY
E
T
-----------------
T
-------------------------
C
PK
C
------------------
G
-----------
G
P
A
-----
K
R
D
T
D
T
M
D
T
F
F
D
S
S
W
Y
---------
Y
L
R
Y
T
D
P
H
-------
N
D
RLPF
D
P
E
K
A
N
A
W
M
P
V
D
Q
Y
I
G
G
V
E
------
H
A
V
L
H
L
L
Y
S
R
-------
F
F
T
K
F
L
H
D
L
GMVK
V
E
E
P
F
Q
G
L
F
T
Q
G
M
V
-------------------------
L
A
WTDF
G
P
V
E
V
E
GS
V
V
R
L
P
E
P
T
R
I
R
L
EIPESALS
L
E
D
V
R
K
M
G
A
E
L
R
P
H
E
D
G
T
L
H
L
W
K
P
A
------------------
V
M
S
K
S
K
G
N
G
V
M
V
G
P
F
V
K
E
Q
G
A
D
I
A
R
I
T
I
L
F
A
A
P
P
E
N
E
M
V
W
T
E
E
G
V
-
Q
G
-
A
W
R
F
L
N
R
I
Y
R
R
V
A
E
D
R
E
A
L
L
E
T
S
G
---------
V
F
Q
A
E
A
L
E
G
K
D
R
E
L
Y
G
K
L
H
E
T
L
K
K
V
T
E
D
L
E
A
---
L
R
F
N
T
A
I
A
A
L
M
E
F
L
-
N
A
L
-
Y
E
Y
R
---
K
D
R
----------------
P
V
T
P
V
Y
R
T
A
I
R
Y
Y
L
Q
M
L
F
P
F
A
P
H
L
A
E
E
L
W
-
H
---
W
F
-------
W
-
P
-------
D
---
S
L
F
E
A
G
W
P
E
L
D
E
K
A
L
E
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------
9
PsiBlast_PDB
80.79
24%
-66
- C1 -
1ILE
2
SYI_THET8
A:
[9-821]
------------------
N
F
P
K
L
E
E
E
V
L
A
F
W
K
R
E
K
I
F
Q
K
S
V
E
--
N
--
R
KG
G
P
R
Y
T
V
Y
E
G
-
P
P
T
A
N
G
L
P
H
V
G
H
A
Q
A
R
S
Y
K
D
L
F
P
R
Y
K
T
M
R
G
Y
Y
A
P
R
R
A
G
W
D
T
H
G
L
P
V
E
L
E
V
E
K
K
L
GLKS
K
R
E
I
E
A
Y
-
G
I
E
R
F
N
---
Q
A
C
R
E
S
V
F
T
Y
E
K
E
W
E
A
F
T
E
----
R
I
A
Y
W
V
D
L
E
D
A
Y
A
T
L
E
P
T
Y
I
E
S
I
W
W
S
L
K
N
L
F
D
R
G
L
L
Y
R
D
H
K
V
V
P
Y
C
P
R
C
G
T
P
L
S
S
H
E
V
--
A
L
G
----------
Y
-------------------------------------------
K
E
-----------
I
Q
D
P
S
-------------------------------------
V
Y
V
--------------------------------------
R
F
P
L
K
E
P
------
K
K
LGLE
K
A
S
L
L
------
I
W
T
T
T
P
W
T
L
P
G
N
V
A
A
A
V
-------------
H
P
E
Y
T
Y
A
A
F
Q
V
GD
E
A
L
I
L
E----------------------
E
G
L
---------
G
-----------------------------------
R
--
K
L
-----------------------------------
L
--------------------
G
E
G
T
Q
V
L
K
T
F
P
GKALEG
L
-------------------------------------
P
Y
----
T
P
P
Y
P
QALEKGY
F
V
V
L
A
D
Y
V
S
Q
E
D
G
T
G
I
V
H
Q
A
P
A
F
G
A
E
D
L
E
T
A
R
V
Y
G
L
P
-
L
L
K
T
V
---------------
D
E
E
G
K
L
------------------
L
--
V
--
E
-------------
P
F
K
G
L
Y
F
R
E
A
N
R
A
I
L
R
D
L
R
G
R
G
L
L
F
K
E
E
S
---------------
Y
L
H
S
Y
P
H
C
W
R
C
S
T
P
L
M
Y
Y
A
T
E
S
W
F
I
K
-
N
T
------------
L
F
K
D
E
L
-
I
R
N
N
Q
E
--
I
H
W
V
P
P
H
I
K
E
G
R
Y
G
E
W
L
K
N
L
V
D
W
A
L
S
R
--------
N
R
Y
W
G
T
P
L
P
I
W
V
-------
C
QA
C
G
-
K
---------------------
E
E
A
I
G
S
F
Q
E
L
K
A
R
AT
K
------------------------
P
----------------------------
L
-------------------------
P
--
E
PFDPHR
P
Y
V
D
Q
V
E
L
A
CAC
G
-----------
G
T
M
-----
R
R
V
P
Y
V
I
D
V
W
Y
D
S
G
A
M
---------
P
F
A
S
L
H
Y
P
-------
F
E
----
H
E
E
V
F
R
E
S
F
P
A
D
F
I
A
E
G
I
D
------
Q
T
R
G
W
F
N
S
L
H
-------
Q
L
G
V
M
L
--
F
----
G
S
I
A
F
K
N
V
I
C
H
G
L
I
-------------------------
L
D
----------------------------------------------
E
K
G
-------
Q
------------------
K
M
S
K
S
K
G
N
V
V
D
P
W
D
I
I
R
K
F
G
A
D
A
L
R
W
Y
I
Y
V
S
A
P
P
E
A
D
R
R
F
G
P
N
L
V
R
E
T
-
V
R
D
Y
F
L
T
L
W
N
V
Y
S
F
F
V
T
Y
A
---
N
L
D
--
R
P
D
L
K
N
P
P
P
P
E
K
R
P
E
M
D
R
W
L
L
A
R
M
Q
D
L
I
Q
R
V
T
E
A
L
E
A
---
Y
D
P
T
T
S
A
R
A
L
R
D
F
V
V
E
D
L
S
Q
W
Y
V
R
R
N
R
R
R
F
W
K
---
N
E
D
AL
D
R
E
--
A
A
Y
A
T
L
Y
E
A
L
V
L
V
A
T
L
A
A
P
F
T
P
F
L
A
E
V
L
W
-
Q
---
N
L
VRSVRLE
A
-
K
-------
E
---
S
V
H
L
A
D
W
P
E
A
D
P
A
L
A
D
--
E
A
L
V
A
Q
M
----
R
A
V
L
K
V
V
D
L
A
R
A
A
R
A
K
S
G
V
------------------------------------------------------------------------------------------------------------------------------------------
6
PsiBlast_PDB
79.72
27%
-71
- C1 -
1FFY
4
SYI1_STAAU
A:
[56-811]
------------------------------------------------------------
P
P
Y
A
N
G
N
L
H
M
G
H
A
L
N
K
I
L
K
D
F
I
V
R
Y
K
T
M
Q
G
F
Y
A
P
Y
V
P
G
W
D
T
H
G
L
P
----
I
E
Q
A
L
-----
T
K
---
K
-
G
V
D
R
K
K
M
S
T
A
E
F
R
E
K
C
K
E
F
A
L
E
Q
I
E
L
Q
K
K
D
F
R
R
L
G
V
R
G
D
F
N
D
P
Y
I
T
L
K
P
E
Y
E
A
A
Q
I
R
I
F
G
E
M
A
D
K
G
L
I
Y
K
G
K
K
P
V
Y
W
S
P
S
S
E
S
S
L
A
E
A
E
I
--
E
------------
Y
-------------------------------------------
H
D
-----------
K
R
S
A
S
-------------------------------------
I
Y
V
--------------------------------------
A
F
N
V
K
D
D
------
K
G
------
V
V
D
AD
A
K
F
I
I
W
T
T
T
P
W
T
I
P
S
N
V
A
I
T
V
-------------
H
P
E
---------------------------------------
L
K
---------
Y
-----------------------------------
G
QY
N
V
-----------------------------------
N
--------------------
G
E
K
Y
I
------------
I
A
E
ALSDAVAEALDWDKAS
I
K
L
E
KEYTGKELEWV
V
A
Q
H
P
F
L
---
D
R
E
S
L
--------
V
I
N
G
D
H
V
T
T
D
A
G
T
G
C
V
H
T
A
P
G
H
G
E
D
D
Y
I
V
G
Q
Q
Y
E
L
P
-
V
I
S
P
I
---------------
D
D
K
G
V
F
--
T
E
--------------
E
--
G
--
G
-------------
Q
F
E
G
M
F
Y
D
K
A
N
K
A
V
T
D
L
L
T
E
K
G
A
L
L
K
L
D
F
---------------
I
T
H
S
Y
P
H
D
W
R
T
K
K
P
V
I
F
R
A
T
P
Q
W
F
A
S
I
S
K
------------
V
R
Q
D
I
L
D
A
I
E
N
T
N
F
K
V
N
W
G
K
T
R
I
-----
Y
N
M
V
R
D
R
G
E
W
V
I
S
R
--------
Q
R
V
W
G
V
P
L
P
V
F
Y
-------
A
--
E
N
-
G
---------------------
E
I
I
M
T
----------
K
------------------------
E
----------------------------
T
V
N
H
V
A
D
L
F
A
E
HGS
N
I
W
F
E
R
EAKDLL
P
--
E
------------------
G
FTHPGSPN---
G
T
F
-----
T
K
E
T
D
I
M
D
V
W
F
D
S
G
S
------------
S
H
R
G
V
L
-------
E
T
----
R
P
---
E
L
S
F
P
A
D
M
Y
L
E
G
S
D
------
Q
Y
R
G
W
F
N
S
S
I
-------
T
T
S
V
A
T
--
R
----
G
V
S
P
Y
K
F
L
L
S
H
G
F
V
-------------------------
M
D
----------------------------------------------
G
E
G
-------
K
------------------
K
M
S
K
S
L
G
N
V
I
V
P
D
Q
V
V
K
Q
K
G
A
D
I
A
R
L
W
V
S
S
T
D
Y
L
A
-
D
V
R
I
S
D
E
I
L
-
K
Q
-
T
S
D
D
Y
R
K
I
R
N
T
L
R
F
M
L
G
N
-----
I
N
D
F
N
P
D
T
D
S
I
P
E
S
E
L
L
E
V
-
D
R
Y
L
L
N
R
L
R
E
F
T
A
S
T
I
N
N
Y
E
N
---
F
D
Y
L
N
I
Y
Q
E
V
Q
N
F
I
N
V
E
L
S
N
F
Y
L
D
Y
G
K
D
I
L
Y
I
E
--
Q
R
D
--
S
H
I
R
R
S
M
Q
T
V
L
Y
Q
I
L
V
D
M
T
K
L
L
A
P
I
L
V
H
T
A
E
E
V
W
-
S
H
TP
H
V
-------
K
-
E
-------
E
---
S
V
H
L
A
D
M
P
K
V
V
E
V
-----------
D
----
Q
A
L
L
D
K
W
R
T
F
M
N
L
R
D
D
V
N
R
A
L
E
T
A
R
N
E
K
V
I
G
K
S
L
E
A
K
V
T
I
A
S
N
D
K
F
N
A
S
E
F
L
T
S
F
D
A
L
H
Q
L
F
I
V
S
Q
V
K
V
V
D
K
L
D
D
Q
A
T
A
Y
E
H
G
D
I
V
I
E
H
A
D
G
E
K
C
E
R
C
W
N
Y
S
E
D
L
G
A
V
D
E
L
T
H
L
C
P
R
C
Q
Q
V
V
K
S
L
V
-------------------------------
4
PsiBlast_PDB
79.72
27%
-71
- C1 -
1QU2
4
SYI1_STAAU
A:
[56-811]
------------------------------------------------------------
P
P
Y
A
N
G
N
L
H
M
G
H
A
L
N
K
I
L
K
D
F
I
V
R
Y
K
T
M
Q
G
F
Y
A
P
Y
V
P
G
W
D
T
H
G
L
P
----
I
E
Q
A
L
-----
T
K
---
K
-
G
V
D
R
K
K
M
S
T
A
E
F
R
E
K
C
K
E
F
A
L
E
Q
I
E
L
Q
K
K
D
F
R
R
L
G
V
R
G
D
F
N
D
P
Y
I
T
L
K
P
E
Y
E
A
A
Q
I
R
I
F
G
E
M
A
D
K
G
L
I
Y
K
G
K
K
P
V
Y
W
S
P
S
S
E
S
S
L
A
E
A
E
I
--
E
------------
Y
-------------------------------------------
H
D
-----------
K
R
S
A
S
-------------------------------------
I
Y
V
--------------------------------------
A
F
N
V
K
D
D
------
K
G
------
V
V
D
AD
A
K
F
I
I
W
T
T
T
P
W
T
I
P
S
N
V
A
I
T
V
-------------
H
P
E
---------------------------------------
L
K
---------
Y
-----------------------------------
G
QY
N
V
-----------------------------------
N
--------------------
G
E
K
Y
I
------------
I
A
E
ALSDAVAEALDWDKAS
I
K
L
E
KEYTGKELEWV
V
A
Q
H
P
F
L
---
D
R
E
S
L
--------
V
I
N
G
D
H
V
T
T
D
A
G
T
G
C
V
H
T
A
P
G
H
G
E
D
D
Y
I
V
G
Q
Q
Y
E
L
P
-
V
I
S
P
I
---------------
D
D
K
G
V
F
--
T
E
--------------
E
--
G
--
G
-------------
Q
F
E
G
M
F
Y
D
K
A
N
K
A
V
T
D
L
L
T
E
K
G
A
L
L
K
L
D
F
---------------
I
T
H
S
Y
P
H
D
W
R
T
K
K
P
V
I
F
R
A
T
P
Q
W
F
A
S
I
S
K
------------
V
R
Q
D
I
L
D
A
I
E
N
T
N
F
K
V
N
W
G
K
T
R
I
-----
Y
N
M
V
R
D
R
G
E
W
V
I
S
R
--------
Q
R
V
W
G
V
P
L
P
V
F
Y
-------
A
--
E
N
-
G
---------------------
E
I
I
M
T
----------
K
------------------------
E
----------------------------
T
V
N
H
V
A
D
L
F
A
E
HGS
N
I
W
F
E
R
EAKDLL
P
--
E
------------------
G
FTHPGSPN---
G
T
F
-----
T
K
E
T
D
I
M
D
V
W
F
D
S
G
S
------------
S
H
R
G
V
L
-------
E
T
----
R
P
---
E
L
S
F
P
A
D
M
Y
L
E
G
S
D
------
Q
Y
R
G
W
F
N
S
S
I
-------
T
T
S
V
A
T
--
R
----
G
V
S
P
Y
K
F
L
L
S
H
G
F
V
-------------------------
M
D
----------------------------------------------
G
E
G
-------
K
------------------
K
M
S
K
S
L
G
N
V
I
V
P
D
Q
V
V
K
Q
K
G
A
D
I
A
R
L
W
V
S
S
T
D
Y
L
A
-
D
V
R
I
S
D
E
I
L
-
K
Q
-
T
S
D
D
Y
R
K
I
R
N
T
L
R
F
M
L
G
N
-----
I
N
D
F
N
P
D
T
D
S
I
P
E
S
E
L
L
E
V
-
D
R
Y
L
L
N
R
L
R
E
F
T
A
S
T
I
N
N
Y
E
N
---
F
D
Y
L
N
I
Y
Q
E
V
Q
N
F
I
N
V
E
L
S
N
F
Y
L
D
Y
G
K
D
I
L
Y
I
E
--
Q
R
D
--
S
H
I
R
R
S
M
Q
T
V
L
Y
Q
I
L
V
D
M
T
K
L
L
A
P
I
L
V
H
T
A
E
E
V
W
-
S
H
TP
H
V
-------
K
-
E
-------
E
---
S
V
H
L
A
D
M
P
K
V
V
E
V
-----------
D
----
Q
A
L
L
D
K
W
R
T
F
M
N
L
R
D
D
V
N
R
A
L
E
T
A
R
N
E
K
V
I
G
K
S
L
E
A
K
V
T
I
A
S
N
D
K
F
N
A
S
E
F
L
T
S
F
D
A
L
H
Q
L
F
I
V
S
Q
V
K
V
V
D
K
L
D
D
Q
A
T
A
Y
E
H
G
D
I
V
I
E
H
A
D
G
E
K
C
E
R
C
W
N
Y
S
E
D
L
G
A
V
D
E
L
T
H
L
C
P
R
C
Q
Q
V
V
K
S
L
V
-------------------------------
5
PsiBlast_PDB
79.26
27%
-70
- C1 -
1QU3
2
SYI1_STAAU
A:
[56-811]
------------------------------------------------------------
P
P
Y
A
N
G
N
L
H
M
G
H
A
L
N
K
I
L
K
D
F
I
V
R
Y
K
T
M
Q
G
F
Y
A
P
Y
V
P
G
W
D
T
H
G
L
P
----
I
E
Q
A
L
-----
T
K
---
K
-
G
V
D
R
K
K
M
S
T
A
E
F
R
E
K
C
K
E
F
A
L
E
Q
I
E
L
Q
K
K
D
F
R
R
L
G
V
R
G
D
F
N
D
P
Y
I
T
L
K
P
E
Y
E
A
A
Q
I
R
I
F
G
E
M
A
D
K
G
L
I
Y
K
G
K
K
P
V
Y
W
S
P
S
S
E
S
S
L
A
E
A
E
I
--
E
------------
Y
-------------------------------------------
H
D
-----------
K
R
S
A
S
-------------------------------------
I
Y
V
--------------------------------------
A
F
N
V
K
D
D
------
K
G
------
V
V
D
A
D
A
K
F
I
I
W
T
T
T
P
W
T
I
P
S
N
V
A
I
T
V
-------------
H
P
E
---------------------------------------
L
K
---------
Y
-----------------------------------
G
Q
Y
N
V
-----------------------------------
N
--------------------
G
E
K
Y
I
------------
I
A
EAL
S
D
A
V
A
E
A
L
DWDKASIKLEKEYTGKELE
W
V
V
A
Q
H
P
F
L
---
D
R
E
S
L
--------
V
I
N
G
D
H
V
T
T
D
A
G
T
G
C
V
H
T
A
P
G
H
G
E
D
D
Y
I
V
G
Q
Q
Y
E
L
P
-
V
I
S
P
I
---------------
D
D
K
G
V
F
--
T
E
--------------
E
--
G
--
G
-------------
Q
F
E
G
M
F
Y
D
K
A
N
K
A
V
T
D
L
L
T
E
K
G
A
L
L
K
L
D
F
---------------
I
T
H
S
Y
P
H
D
W
R
T
K
K
P
V
I
F
R
A
T
P
Q
W
F
A
S
I
S
K
------------
V
R
Q
D
I
L
D
A
I
E
N
T
N
F
K
V
N
W
G
K
T
R
I
-----
Y
N
M
V
R
D
R
G
E
W
V
I
S
R
--------
Q
R
V
W
G
V
P
L
P
V
F
Y
-------
A
--
E
N
-
G
---------------------
E
I
I
M
T
----------
K
------------------------
E
----------------------------
T
V
N
H
V
A
D
L
F
A
E
H
GSNIWFEREAKDLL
P
--
E
------------------
G
FTHPGSPN---
G
T
F
-----
T
K
E
T
D
I
M
D
V
W
F
D
S
G
S
------------
S
H
R
G
V
L
-------
E
T
----
R
P
---
E
L
S
F
P
A
D
M
Y
L
E
G
S
D
------
Q
Y
R
G
W
F
N
S
S
I
-------
T
T
S
V
A
T
--
R
----
G
V
S
P
Y
K
F
L
L
S
H
G
F
V
-------------------------
M
D
----------------------------------------------
G
E
G
-------
K
------------------
K
M
S
K
S
L
G
N
V
I
V
P
D
Q
V
V
K
Q
K
G
A
D
I
A
R
L
W
V
S
S
T
D
Y
L
A
-
D
V
R
I
S
D
E
I
L
-
K
Q
-
T
S
D
D
Y
R
K
I
R
N
T
L
R
F
M
L
G
N
-----
I
N
D
F
N
P
D
T
D
S
I
P
E
S
E
L
L
E
V
-
D
R
Y
L
L
N
R
L
R
E
F
T
A
S
T
I
N
N
Y
E
N
---
F
D
Y
L
N
I
Y
Q
E
V
Q
N
F
I
N
V
E
L
S
N
F
Y
L
D
Y
G
K
D
I
L
Y
I
E
--
Q
R
D
--
S
H
I
R
R
S
M
Q
T
V
L
Y
Q
I
L
V
D
M
T
K
L
L
A
P
I
L
V
H
T
A
E
E
V
W
-
S
H
TP
H
V
-------
K
-
E
-------
E
---
S
V
H
L
A
D
M
P
K
V
V
E
V
-----------
D
----
Q
A
L
L
D
K
W
R
T
F
M
N
L
R
D
D
V
N
R
A
L
E
T
A
R
N
E
K
V
I
G
K
S
L
E
A
K
V
T
I
A
S
N
D
K
F
N
A
S
E
F
L
T
S
F
D
A
L
H
Q
L
F
I
V
S
Q
V
K
V
V
D
K
L
D
D
Q
A
T
A
Y
E
H
G
D
I
V
I
E
H
A
-------------------------------------------------------------------
3
PsiBlast_PDB
79.24
39%
94
- C- -
1IYW
-
SYV_THETH
A:
[2-843]
------------
D
L
P
K
A
Y
D
P
K
S
V
E
P
K
W
A
E
K
W
-
A
K
N
P
F
V
A
N
P
K
--
S
--
G
--
K
P
P
F
V
I
F
M
P
-
P
P
N
V
T
G
S
L
H
M
G
H
A
L
D
N
S
L
Q
D
A
L
I
R
Y
K
R
M
R
G
F
E
A
V
W
L
P
G
T
D
H
A
G
I
A
T
Q
V
V
V
E
R
L
L
-----
L
K
---
E
-
G
K
T
R
H
D
L
G
R
E
K
F
L
E
R
V
W
Q
W
K
E
E
S
G
G
T
I
L
K
Q
L
K
R
L
G
A
S
A
D
W
S
R
E
A
F
T
M
D
E
K
R
S
R
A
V
R
Y
A
F
S
R
Y
Y
H
E
G
L
A
Y
R
A
P
R
L
V
N
W
C
P
R
C
E
T
T
L
S
D
L
E
V
--
E
------------
T
-------------------------------------------
E
P
-----------
T
P
G
K
L
-------------------------------------
Y
T
L
--------------------------------------
R
Y
E
V
E
G
G
------
G
-------
F
I
E
------
I
A
T
V
R
P
E
T
V
F
A
D
Q
A
I
A
V
-------------
H
P
E
--------------------------------------
D
E
R
---------
Y
-----------------------------------
R
--
H
L
-----------------------------------
L
--------------------
G
K
R
A
R
------------
I
-------------------------------------
P
L
T
---
E
V
W
I
P
--------
I
L
A
D
P
A
V
E
K
D
F
G
T
G
A
L
K
V
T
P
A
H
D
P
L
D
Y
E
I
G
E
R
H
G
L
K
-
P
V
S
V
I
---------------
N
L
E
G
R
M
E
G
E
R
--------------
V
--
P
--
E
-------------
A
L
R
G
L
D
R
F
E
A
R
R
K
A
V
E
L
F
R
E
A
G
H
L
V
K
E
E
D
---------------
Y
T
I
A
L
A
T
C
S
R
C
G
T
P
I
E
Y
A
I
F
P
Q
W
W
L
R
M
R
P
------------
L
A
E
E
V
L
-
K
G
L
R
R
G
D
-
I
A
F
V
P
E
R
W
K
K
-
V
N
M
D
W
L
E
N
V
K
D
W
N
I
S
R
--------
Q
L
W
W
G
H
Q
I
P
A
W
Y
C
EDCQAV
N
--
V
P
-
R
---------------------
P
E
R
Y
L
----------
E
------------------------
D
----------------------------
P
-------------------------
T
--
S
------------------
C
-----------
E
A
C
GSPRL
K
R
D
E
D
V
F
D
T
W
F
S
S
A
L
W
---------
P
L
S
T
L
G
W
P
-------
E
-----
E
T
E
D
L
K
A
F
Y
P
G
D
V
L
V
T
G
Y
D
------
I
L
F
L
W
V
S
R
M
E
-------
V
S
G
Y
H
F
--
M
----
G
E
R
P
F
K
T
V
L
L
H
G
L
V
-------------------------
L
D
----------------------------------------------
E
K
G
-------
Q
------------------
K
M
S
K
S
K
G
N
V
I
D
P
L
E
M
V
E
R
Y
G
A
D
A
L
R
F
A
L
I
Y
L
A
T
G
G
Q
D
I
R
L
D
L
R
W
L
-
E
M
-
A
R
N
F
A
N
K
L
Y
N
A
A
R
F
V
L
L
S
R
E
G
F
---
Q
A
K
E
D
T
P
--------
T
L
A
D
R
F
M
R
S
R
L
S
R
G
V
E
E
I
T
A
L
Y
E
A
---
L
D
L
A
Q
A
A
R
E
V
Y
E
L
V
W
S
E
F
C
D
W
Y
L
E
A
A
K
P
A
L
K
A
G
--
N
A
H
--------
T
L
R
T
L
E
E
V
L
A
V
L
L
K
L
L
H
P
M
M
P
F
L
T
S
E
L
Y
Q
A
---
L
T
-------
G
-
K
-------
E
---
E
L
A
L
E
A
W
P
E
P
G
G
--
R
D
--
E
E
A
E
R
A
F
----
E
A
L
K
Q
A
V
T
A
V
R
A
L
K
A
E
A
G
L
P
P
A
Q
E
V
R
V
Y
L
E
G
E
T
A
P
V
E
----
E
N
L
E
V
F
R
F
L
S
R
A
D
L
L
P
-----
E
R
P
A
K
A
L
V
K
A
M
P
R
V
T
A
R
M
P
L
E
G
L
L
D
V
E
E
W
R
R
R
Q
E
K
R
L
K
E
L
L
A
L
A
E
R
S
Q
R
K
L
A
S
P
G
F
R
E
K
A
P
K
E
V
V
E
A
E
E
A
R
L
K
E
N
L
E
Q
A
E
R
I
R
E
A
L
S
Q
I
G
-----
17
PsiBlast_PDB
75.49
21%
-58
- C1 -
3ZGZ
2
SYL_ECOLI
A:
[21-808]
-------------
M
Q
E
Q
Y
R
P
E
E
I
E
S
K
V
Q
L
H
W
D
E
K
R
T
F
E
V
T
E
D
--
E
--
S
--
K
E
K
Y
Y
C
L
S
M
-
L
P
Y
P
S
G
R
L
H
M
G
H
V
R
N
Y
T
I
G
D
V
I
A
R
Y
Q
R
M
L
G
K
N
V
L
Q
P
I
G
W
D
A
F
G
L
P
A
E
G
A
A
V
K
N
N
-----
T
A
---
P
-
A
----------------
P
W
T
Y
D
N
I
A
Y
M
K
N
Q
L
K
M
L
G
F
G
Y
D
W
S
R
E
L
A
T
C
T
P
E
Y
Y
R
W
E
Q
K
F
F
T
E
L
Y
K
K
G
L
V
Y
K
K
T
S
A
V
N
W
C
P
N
D
Q
T
V
L
A
N
E
Q
V
--
I
DGCCWRCD
T
K
V
E
R
-------------------------------------------
K
E
-----------
I
P
Q
W
F
I
KITAY
A
D
E
L
L
N
D
L
DKLDHWP
D
T
V
K
T
M
Q
R
N
W
I
G
R
S
E
G
V
E
I
--------------------------------------
T
F
N
V
N
D
Y
------
D
N
------
T
L
T
------
V
Y
T
T
R
P
D
T
F
M
G
C
T
Y
L
A
V
A
AGH
P
L
A
Q
K
A
A
E
N
N
P
E
--------------------------------------
L
A
A
---------
F
-----------------------------------
I
--
D
E
-----------------------------------
C
R
N
TKVA
E
A
E
M
A
T
ME
K
K
G
V
D
T
G
F
K
A
V
------------
H
-------------------------------------
P
L
T
---
G
E
E
I
P
--------
V
W
A
A
N
F
V
L
M
E
Y
G
T
G
A
V
M
A
V
P
G
H
D
Q
R
D
Y
E
F
A
S
K
Y
G
L
N
I
K
P
V
I
L
---------------
A
A
D
G
S
E
--
P
D
--------------
L
--
S
--
Q
QALT
E
K
G
V
L
F
NSG
E
F
N
G
L
D
H
E
A
A
F
N
A
I
A
D
K
L
T
A
M
G
--------------------------
V
G
E
R
K
-----
V
N
Y
R
L
R
-
D
W
G
V
S
R
Q
R
------------
Y
W
G
A
P
I
-
P
M
V
T
L
E
D
G
T
V
M
P
T
P
D
D
Q
L
-
P
V
I
L
P
E
D
V
V
M
D
G
I
T
S
P
--------
I
----
K
A
D
P
E
W
A
K
T
-----
T
--
V
N
-
G
---------------------
M
P
A
L
R
----------
E
----------------------------------------------------------------------------------------------------------------------------
T
D
T
F
D
T
F
M
E
S
S
-
W
---------
Y
Y
A
R
Y
T
C
P
QYKEGML
D
S
----
E
A
A
N
Y
--
W
L
P
V
D
I
Y
I
G
G
I
E
HAI
M
H
L
L
Y
F
R
F
F
H
K
L
M
-------
R
D
A
G
M
V
--
N
----
S
D
E
P
A
K
Q
L
L
C
Q
G
M
V
L
A
D
A
F
Y
Y
V
G
ENG
E
R
N
W
V
S
PVD
A
I
V
E
R
D
----------------------------------------------
E
K
G
-------
R
IV
K
A
K
D
AAGHELVYTGMS
K
M
S
K
S
K
N
N
G
I
D
P
Q
V
M
V
E
R
Y
G
A
D
T
V
R
L
F
M
M
F
A
S
P
A
D
M
T
L
E
W
Q
E
S
G
V
-
E
G
-
A
N
R
F
L
K
R
V
W
K
-----
L
V
Y
E
H
T
A
K
G
D
V
A
A
L
N
V
D
A
L
T
E
N
Q
------
K
A
L
R
R
D
V
H
K
T
I
A
K
V
T
D
D
I
G
R
RQT
F
N
T
A
I
A
A
I
M
-------
E
L
M
N
---
K
L
A
K
A
P
--
T
D
--
G
E
Q
--
D
R
A
--
L
M
Q
E
A
L
L
----
A
V
V
R
M
L
N
P
F
T
P
H
I
C
F
T
L
W
-
Q
---
E
L
K------
G
-
E
-------
G
---
D
I
D
N
A
P
W
P
V
A
D
E
K
A
M
V
--
E
D
S
T
L
V
V
----
V
Q
V
N
G
K
V
R
A
K
I
T
V
P
V
D
A
T
E
E
Q
V
R
E
R
A
G
Q
E
H
L
V
A
K
Y
L
D
G
V
T
V
R
K
V
I
Y
V
P
G
K
L
L
N
L
V
V
G
----------------------------------------------------------------------------------------------------
13
PsiBlast_PDB
75.33
21%
-57
- C1 -
4AQ7
3
SYL_ECOLI
A:
[21-808]
-------------
M
Q
E
Q
Y
R
P
E
E
I
E
S
K
V
Q
L
H
W
D
E
K
R
T
F
E
V
T
E
D
--
E
--
S
--
K
E
K
Y
Y
C
L
S
M
-
L
P
Y
P
S
G
R
L
H
M
G
H
V
R
N
Y
T
I
G
D
V
I
A
R
Y
Q
R
M
L
G
K
N
V
L
Q
P
I
G
W
D
A
F
G
L
P
A
E
G
A
A
V
K
N
N
-----
T
A
---
P
-
A
----------------
P
W
T
Y
D
N
I
A
Y
M
K
N
Q
L
K
M
L
G
F
G
Y
D
W
S
R
E
L
A
T
C
T
P
E
Y
Y
R
W
E
Q
K
F
F
T
E
L
Y
K
K
G
L
V
Y
K
K
T
S
A
V
N
W
C
P
N
D
Q
T
V
L
A
N
E
Q
V
--
I
DGCCWRCD
T
K
V
E
R
-------------------------------------------
K
E
-----------
I
P
Q
W
F
I
KITAY
A
D
E
L
L
N
D
L
DKLDHWP
D
T
V
K
T
M
Q
R
N
W
I
G
R
S
E
G
V
E
I
--------------------------------------
T
F
N
V
N
D
Y
------
D
N
------
T
L
T
------
V
Y
T
T
R
P
D
T
F
M
G
C
T
Y
L
A
V
A
AGH
P
L
A
Q
K
A
A
E
N
N
P
E
--------------------------------------
L
A
A
---------
F
-----------------------------------
I
--
D
E
-----------------------------------
C
R
NTKVA
E
A
E
M
A
T
ME
K
K
G
V
D
T
G
F
K
A
V
------------
H
-------------------------------------
P
L
T
---
G
E
E
I
P
--------
V
W
A
A
N
F
V
L
M
E
Y
G
T
G
A
V
M
A
V
P
G
H
D
Q
R
D
Y
E
F
A
S
K
Y
G
L
N
I
K
P
V
I
L
---------------
A
A
D
G
S
E
--
P
D
--------------
L
--
S
--
Q
QALT
E
K
G
V
L
F
NSG
E
F
N
G
L
D
H
E
A
A
F
N
A
I
A
D
K
L
T
A
M
G
--------------------------
V
G
E
R
K
-----
V
N
Y
R
L
R
-
D
W
G
V
S
R
Q
R
------------
Y
W
G
A
P
I
-
P
M
V
T
L
E
D
G
T
V
M
P
T
P
D
D
Q
L
-
P
V
I
L
P
E
D
V
V
M
D
G
I
T
S
P
--------
I
----
K
A
D
P
E
W
A
K
T
-----
T
--
V
N
-
G
---------------------
M
P
A
L
R
----------
E
----------------------------------------------------------------------------------------------------------------------------
T
D
T
F
D
T
F
M
E
S
S
-
W
---------
Y
Y
A
R
Y
T
C
P
QYKEGML
D
S
----
E
A
A
N
Y
--
W
L
P
V
D
I
Y
I
G
G
I
E
HAIM
H
L
L
Y
F
R
F
F
H
K
L
M
-------
R
D
A
G
M
V
--
N
----
S
D
E
P
A
K
Q
L
L
C
Q
G
M
V
L
A
D
A
F
Y
Y
V
G
ENG
E
R
N
W
V
S
PVD
A
I
V
E
R
D
----------------------------------------------
E
K
G
-------
R
IV
K
A
K
D
AAGHELVYTGMS
K
M
S
K
S
K
N
N
G
I
D
P
Q
V
M
V
E
R
Y
G
A
D
T
V
R
L
F
M
M
F
A
S
P
A
D
M
T
L
E
W
Q
E
S
G
V
-
E
G
-
A
N
R
F
L
K
R
V
W
K
-----
L
V
Y
E
H
T
A
K
G
D
V
A
A
L
N
V
D
A
L
T
E
N
Q
------
K
A
L
R
R
D
V
H
K
T
I
A
K
V
T
D
D
I
G
R
RQT
F
N
T
A
I
A
A
I
M
-------
E
L
M
N
---
K
L
A
K
A
P
--
T
D
--
G
E
Q
--
D
R
A
--
L
M
Q
E
A
L
L
----
A
V
V
R
M
L
N
P
F
T
P
H
I
C
F
T
L
W
-
Q
---
E
L
K------
G
-
E
-------
G
---
D
I
D
N
A
P
W
P
V
A
D
E
K
A
M
V
--
E
D
S
T
L
V
V
----
V
Q
V
N
G
K
V
R
A
K
I
T
V
P
V
D
A
T
E
E
Q
V
R
E
R
A
G
Q
E
H
L
V
A
K
Y
L
D
G
V
T
V
R
K
V
I
Y
V
P
G
K
L
L
N
L
V
V
G
----------------------------------------------------------------------------------------------------
105
Fugue
75.26
22%
-49
- C1 -
2BYT
13
?
A:
[1-876]
--------------
M
E
K
Y
N
P
H
A
I
E
A
K
W
Q
R
F
W
E
E
K
G
F
M
K
A
K
D
L
--
P
--
G
--
G
R
G
K
Q
Y
V
L
V
M
F
P
Y
P
S
G
D
L
H
M
G
H
L
K
N
Y
T
M
G
D
V
L
A
R
F
R
R
M
Q
G
Y
E
V
L
H
P
M
G
W
D
A
F
G
L
P
A
E
N
A
A
L
K
F
G
-----
V
--------------------
H
P
K
D
W
T
Y
A
N
I
R
Q
A
K
E
S
L
R
L
M
G
I
L
Y
D
W
D
R
E
V
T
T
C
E
P
E
Y
Y
R
W
N
Q
W
I
F
L
K
M
W
E
K
G
L
A
Y
R
A
K
G
L
V
N
W
C
P
K
C
Q
T
V
L
A
N
E
Q
V
--
V
------------
E
GRCWRHED
T
P
V
E
K
R
E
L
E
Q
W
Y
L
RITAY
A
E
R
L
L
K
D
LEGLNWP
E
K
V
K
A
-----------
M
Q
R
A
W
I
G
R
S
E
G
-------------------------------
A
E
I
--------------------------------------
L
F
P
V
E
G
K
------
E
V
------
R
I
P
------
V
F
T
T
R
P
D
T
L
F
G
A
T
F
L
V
L
-------------
A
P
E
--------------------------------------
H
P
L
---------
T
-----------------------------------
L
--
E
L
AAPEK
R
E
E
V
L
A
Y
V
E
A
A
K
R
KT
E
I
E
R
Q
A
E
GR
E
K
T
G
V
F
L
--------------------
G
A
Y
A
L
------------
N
-------------------------------------
P
A
T
---
G
E
R
I
P
--------
I
W
T
A
D
Y
V
L
F
G
Y
G
T
G
A
I
M
A
V
P
A
H
D
Q
R
D
Y
E
F
A
R
K
F
G
L
P
-
I
K
K
V
I
ERPGEPLPEPLERAY
E
E
P
G
I
M
--
V
N
-----------------
S
--
G
-------------
P
F
D
G
T
E
S
E
E
G
K
R
K
V
I
A
W
L
E
E
K
G
L
G
K
G
R
V
T
Y
RLRDWLISRQRYWG
T
P
I
P
M
V
H
C
E
A
C
G
V
V
P
V
P
E
E
E
L
P
V
L
L
P
D
L
K
DVEDIRPKGKSP
L
E
A
H
P
E
-
F
Y
E
T
T
C
P
K
C
G
G
P
A
K
R
D
T
D
-
T
M
D
T
F
F
D
S
S
--
W
Y
Y
L
R
Y
T
D
PHNDR
L
P
F
D
P
E
K
A
N
A
W
M
-------
P
--
V
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------------------------
Q
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----------------------------------------------------------------------------------------------------------------
G
-----------
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-----
A
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P
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----
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-------------------------
H
L
----------------------------------------------
W
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---------
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---
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-----------------
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---
W
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-------
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A
----------------------------------
L
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K
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V
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V
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V
N
G
R
V
R
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-----------------
T
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A
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A
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---------------------------
L
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V
V
-----------------------------