@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : gbs1024: (2015-12-04 )
MAEYNWDERHIITFPEENSALTTKDLHVYYGEKEAIKGIDMQFEKNKITALIGPSGCGKSTYLRSLNRMNDTIDIARVTGQIMYEGIDVNAQDINVYEMRKHIGMVFQRPNPFAKSIYKNITFAYERAGVKDKKFLDEVVETSLKQAALWDQVKDDLHKSAFTLSGGQQQRLCIARAIAVKPEILLMDEPASALDPIATMQLEETMFELKKNYTIIIVTHNMQQAARASDYTAFFYLGDLIEYDKTNNIFQNAKCQSTSDYVSGRFG
Atome Classification :
(26 SA)
.........10........20........---30........40........50........60........70........80........90.-----------.......100.......110..-.-....120.......130.......140.......150.--......160.......170.......180.......190.......200.......-210-........220.......230.......240.......250.......260.....
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MAEYNWDE
R
H
I
I
T
FPEENSALT
T
K
D
L
H
V
Y
---YGE
K
E
A
IKGID
M
Q
F
EKN
K
I
T
A
L
IGPSGCG
K
S
T
Y
L
R
S
L
N
RMNDT
I
D
I
A
R
V
T
G
Q
I
M
YEGIDVNAQ-----------D
I
N
V
Y
E
M
R
K
H
I
G
M
VFQRP
N
P
F
A
-
K
-
S
I
Y
K
N
I
T
F
A
Y
ERAGVK
D
K
K
F
L
D
E
V
V
E
T
S
L
K
Q
A
A
L
W
D
Q
V
--
K
D
D
L
H
KS
A
F
TLSGGQQ
Q
R
L
C
I
A
R
A
IAVK
P
E
I
L
L
MDEPASALDP
I
A
T
M
Q
L
E
E
T
M
F
E
L
-K-K-N
Y
T
I
I
I
V
TH
N
M
Q
Q
A
ARASD
Y
T
A
F
F
Y
L
G
D
L
IEYDKTNN
I
F
QNAKCQSTSDYVSGRFG
79
HHSearch
93.97
32%
-96
- C1 -
1B0U
4
HISP_SALTY
A:
[5-256]
------------------
N
K
L
H
V
I
D
L
H
K
R
---
Y
G
G
H
E
V
L
K
G
V
S
L
Q
A
R
A
G
D
V
I
S
I
I
G
S
S
G
S
G
K
S
T
F
L
R
C
I
N
F
L
E
K
P
-----
S
E
G
A
I
I
V
N
G
Q
N
I
N
L
V
R
D
KDGQLKVAD
K
N
Q
L
R
L
L
R
T
R
L
T
M
V
F
Q
H
F
N
L
W
S
H
M
-
T
V
L
E
N
V
M
E
A
P
I
Q
V
L
G
L
S
K
H
D
A
R
E
R
A
L
K
Y
L
A
K
V
G
I
D
E
R
A
-----
Q
G
K
Y
P
V
H
L
S
G
G
Q
Q
Q
R
V
S
I
A
R
A
L
A
M
E
P
D
V
L
L
F
D
E
P
T
S
A
L
D
P
E
L
V
G
E
V
L
R
I
M
Q
Q
L
A
E
-
E
-
G
K
T
M
V
V
V
T
H
E
M
G
F
A
R
H
V
S
S
H
V
I
F
L
H
Q
G
K
I
E
E
E
G
D
P
E
Q
V
F
G
N
P
Q
S
P
R
L
Q
Q
F
L
K
G
S
L
K
21
PsiBlast_CBE
92.89
36%
-93
- C1 -
3C4J
4
?
B:
[22-263]
--------------------
L
Q
M
I
D
V
H
Q
L
KKS
F
G
S
L
E
V
L
K
G
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
E
D
F
D
E
-----
G
E
I
I
I
D
G
I
N
L
K
A
K
-----------
D
T
N
L
N
K
V
R
E
E
V
G
M
V
F
Q
R
F
N
L
F
P
-
H
M
T
V
L
N
N
I
T
L
A
P
----
M
K
V
R
K
W
P
R
E
K
A
E
A
--
K
A
M
E
L
L
D
K
V
GL
K
D
K
A
H
A
Y
P
D
S
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
S
V
M
K
Q
L
A
N
-
E
-
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
L
F
M
D
G
G
Y
I
I
E
E
G
K
P
E
D
L
F
D
R
P
Q
H
E
R
T
K
A
F
L
S
K
V
F
-
24
PsiBlast_CBE
89.57
36%
-87
- C1 -
2OUK
1
?
C:
[22-263]
--------------------
L
Q
M
I
D
V
H
Q
L
KKS
F
G
S
L
E
V
L
K
G
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
E
D
F
D
E
-----
G
E
I
I
I
D
G
I
N
L
K
A
K
-----------
D
T
N
L
N
K
V
R
E
E
V
G
M
V
F
Q
R
F
N
L
F
P
-
H
M
T
V
L
N
N
I
T
L
A
P
----
M
K
V
R
K
W
P
R
E
K
A
E
A
--
K
A
M
E
L
L
D
K
V
GL
K
D
K
A
H
A
Y
P
D
S
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
S
V
M
K
Q
L
A
N
-
E
-
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
L
F
M
D
G
G
Y
I
I
E
E
G
K
P
E
D
L
F
D
R
P
Q
H
E
R
T
K
A
F
L
S
K
V
F
-
5
PsiBlast_PDB
89.33
36%
-89
- C1 -
3C4J
3
?
A:
[22-263]
--------------------
L
Q
M
I
D
V
H
Q
L
K
K
S
F
G
S
L
E
V
L
K
G
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
E
D
F
D
E
-----
G
E
I
I
I
D
G
I
N
L
K
A
K
-----------
D
T
N
L
N
K
V
R
E
E
V
G
M
V
F
Q
R
F
N
L
F
P
-
H
M
T
V
L
N
N
I
T
L
A
P
----
M
K
V
R
K
W
P
R
E
K
A
E
A
--
K
A
M
E
L
L
D
K
V
GL
K
D
K
A
H
A
Y
P
D
S
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
S
V
M
K
Q
L
A
N
-
E
-
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
L
F
M
D
G
G
Y
I
I
E
E
G
K
P
E
D
L
F
D
R
P
Q
H
E
R
T
K
A
F
L
S
K
V
F
-
78
HHSearch
89.30
35%
-85
- C1 -
2OLJ
4
?
A:
[22-263]
-----------------
L
Q
M
I
D
V
H
Q
L
K
K
S
---
F
G
S
L
E
V
L
K
G
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
E
D
F
-----
D
E
G
E
I
I
I
D
G
I
N
L
K
A
K
-----------
D
T
N
L
N
K
V
R
E
E
V
G
M
V
F
Q
R
F
N
L
F
P
H
M
-
T
V
L
N
N
I
T
L
A
P
M
K
V
R
K
W
P
R
E
K
A
E
A
K
A
M
E
L
L
D
K
V
G
L
K
D
------
K
A
H
A
Y
P
D
S
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
S
V
M
K
Q
L
-
A
N
E
-
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
L
F
M
D
G
G
Y
I
I
E
E
G
K
P
E
D
L
F
D
R
P
Q
H
E
R
T
K
A
F
L
S
K
V
F
-
3
PsiBlast_PDB
88.96
36%
-86
- C1 -
2OUK
1
?
A:
[22-263]
--------------------
L
Q
M
I
D
V
H
Q
L
K
K
S
F
G
S
L
E
V
L
K
G
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
E
D
F
D
E
-----
G
E
I
I
I
D
G
I
N
L
K
A
K
-----------
D
T
N
L
N
K
V
R
E
E
V
G
M
V
F
Q
R
F
N
L
F
P
-
H
M
T
V
L
N
N
I
T
L
A
P
----
M
K
V
R
K
W
P
R
E
K
A
E
A
--
K
A
M
E
L
L
D
K
V
GL
K
D
K
A
H
A
Y
P
D
S
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
S
V
M
K
Q
L
A
N
-
E
-
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
L
F
M
D
G
G
Y
I
I
E
E
G
K
P
E
D
L
F
D
R
P
Q
H
E
R
T
K
A
F
L
S
K
V
F
-
1
PsiBlast_PDB
88.37
36%
-88
- C1 -
2OLJ
4
?
A:
[22-263]
--------------------
L
Q
M
I
D
V
H
Q
L
K
K
S
F
G
S
L
E
V
L
K
G
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
E
D
F
D
E
-----
G
E
I
I
I
D
G
I
N
L
K
A
K
-----------
D
T
N
L
N
K
V
R
E
E
V
G
M
V
F
Q
R
F
N
L
F
P
-
H
M
T
V
L
N
N
I
T
L
A
P
----
M
K
V
R
K
W
P
R
E
K
A
E
A
--
K
A
M
E
L
L
D
K
V
GL
K
D
K
A
H
A
Y
P
D
S
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
S
V
M
K
Q
L
A
N
-
E
-
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
L
F
M
D
G
G
Y
I
I
E
E
G
K
P
E
D
L
F
D
R
P
Q
H
E
R
T
K
A
F
L
S
K
V
F
-
23
PsiBlast_CBE
88.35
36%
-88
- C1 -
2OUK
2
?
D:
[23-263]
---------------------
Q
M
I
D
V
H
Q
L
KKS
F
G
S
L
E
V
L
K
G
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
E
D
F
D
E
-----
G
E
I
I
I
D
G
I
N
L
K
A
K
-----------
D
T
N
L
N
K
V
R
E
E
V
G
M
V
F
Q
R
F
N
L
F
P
-
H
M
T
V
L
N
N
I
T
L
A
P
----
M
K
V
R
K
W
P
R
E
K
A
E
A
--
K
A
M
E
L
L
D
K
V
GL
K
D
K
A
H
A
Y
P
D
S
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
S
V
M
K
Q
L
A
N
-
E
-
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
L
F
M
D
G
G
Y
I
I
E
E
G
K
P
E
D
L
F
D
R
P
Q
H
E
R
T
K
A
F
L
S
K
V
F
-
28
PsiBlast_CBE
87.20
36%
-91
- C1 -
2OLK
2
?
B:
[22-263]
--------------------
L
Q
M
I
D
V
H
Q
L
KKS
F
G
S
L
E
V
L
K
G
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
E
D
F
D
E
-----
G
E
I
I
I
D
G
I
N
L
K
A
K
-----------
D
T
N
L
N
K
V
R
E
E
V
G
M
V
F
Q
R
F
N
L
F
P
-
H
M
T
V
L
N
N
I
T
L
A
P
----
M
K
V
R
K
W
P
R
E
K
A
E
A
--
K
A
M
E
L
L
D
K
V
GL
K
D
K
A
H
A
Y
P
D
S
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
S
V
M
K
Q
L
A
N
-
E
-
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
L
F
M
D
G
G
Y
I
I
E
E
G
K
P
E
D
L
F
D
R
P
Q
H
E
R
T
K
A
F
L
S
K
V
F
-
6
PsiBlast_PDB
87.10
37%
-90
- C1 -
3C41
3
?
J:
[13-242]
--------------------------------
F
G
S
L
E
V
L
K
G
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
E
D
F
D
E
-----
G
E
I
I
I
D
G
I
N
L
K
A
K
-----------
D
T
N
L
N
K
V
R
E
E
V
G
M
V
F
Q
R
F
N
L
F
P
-
H
M
T
V
L
N
N
I
T
L
A
P
----
M
K
V
R
K
W
P
R
E
K
A
E
A
--
K
A
M
E
L
L
D
K
V
GL
K
D
K
A
H
A
Y
P
D
S
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
S
V
M
K
Q
L
A
N
-
E
-
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
L
F
M
D
G
G
Y
I
I
E
E
G
K
P
E
D
L
F
D
R
P
Q
H
E
R
T
K
A
F
L
S
K
V
F
-
26
PsiBlast_CBE
87.08
36%
-88
- C1 -
2OLK
1
?
D:
[22-263]
--------------------
L
Q
M
I
D
V
H
Q
L
KKS
F
G
S
L
E
V
L
K
G
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
E
D
F
D
E
-----
G
E
I
I
I
D
G
I
N
L
K
A
K
-----------
D
T
N
L
N
K
V
R
E
E
V
G
M
V
F
Q
R
F
N
L
F
P
-
H
M
T
V
L
N
N
I
T
L
A
P
----
M
K
V
R
K
W
P
R
E
K
A
E
A
--
K
A
M
E
L
L
D
K
V
GL
K
D
K
A
H
A
Y
P
D
S
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
S
V
M
K
Q
L
A
N
-
E
-
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
L
F
M
D
G
G
Y
I
I
E
E
G
K
P
E
D
L
F
D
R
P
Q
H
E
R
T
K
A
F
L
S
K
V
F
-
29
PsiBlast_CBE
87.07
36%
-89
- C1 -
2OLJ
3
?
B:
[22-263]
--------------------
L
Q
M
I
D
V
H
Q
L
KKS
F
G
S
L
E
V
L
K
G
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
E
D
F
D
E
-----
G
E
I
I
I
D
G
I
N
L
K
A
K
-----------
D
T
N
L
N
K
V
R
E
E
V
G
M
V
F
Q
R
F
N
L
F
P
-
H
M
T
V
L
N
N
I
T
L
A
P
----
M
K
V
R
K
W
P
R
E
K
A
E
A
--
K
A
M
E
L
L
D
K
V
GL
K
D
K
A
H
A
Y
P
D
S
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
S
V
M
K
Q
L
A
N
-
E
-
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
L
F
M
D
G
G
Y
I
I
E
E
G
K
P
E
D
L
F
D
R
P
Q
H
E
R
T
K
A
F
L
S
K
V
F
-
30
PsiBlast_CBE
86.49
37%
-94
- C1 -
3C41
3
?
K:
[13-242]
--------------------------------
F
G
S
L
E
V
L
K
G
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
E
D
F
D
E
-----
G
E
I
I
I
D
G
I
N
L
K
A
K
-----------
D
T
N
L
N
K
V
R
E
E
V
G
M
V
F
Q
R
F
N
L
F
P
-
H
M
T
V
L
N
N
I
T
L
A
P
----
M
K
V
R
K
W
P
R
E
K
A
E
A
--
K
A
M
E
L
L
D
K
V
GL
K
D
K
A
H
A
Y
P
D
S
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
S
V
M
K
Q
L
A
N
-
E
-
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
L
F
M
D
G
G
Y
I
I
E
E
G
K
P
E
D
L
F
D
R
P
Q
H
E
R
T
K
A
F
L
S
K
V
F
-
25
PsiBlast_CBE
86.14
36%
-87
- C1 -
2OUK
2
?
B:
[23-263]
---------------------
Q
M
I
D
V
H
Q
L
K
K
S
F
G
S
L
E
V
L
K
G
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
E
D
F
D
E
-----
G
E
I
I
I
D
G
I
N
L
K
A
K
-----------
D
T
N
L
N
K
V
R
E
E
V
G
M
V
F
Q
R
F
N
L
F
P
-
H
M
T
V
L
N
N
I
T
L
A
P
----
M
K
V
R
K
W
P
R
E
K
A
E
A
--
K
A
M
E
L
L
D
K
V
GL
K
D
K
A
H
A
Y
P
D
S
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
S
V
M
K
Q
L
A
N
-
E
-
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
L
F
M
D
G
G
Y
I
I
E
E
G
K
P
E
D
L
F
D
R
P
Q
H
E
R
T
K
A
F
L
S
K
V
F
-
4
PsiBlast_PDB
86.07
36%
-86
- C1 -
2Q0H
4
?
A:
[23-263]
---------------------
Q
M
I
D
V
H
Q
L
K
K
S
F
G
S
L
E
V
L
K
G
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
E
D
F
D
E
-----
G
E
I
I
I
D
G
I
N
L
K
A
K
-----------
D
T
N
L
N
K
V
R
E
E
V
G
M
V
F
Q
R
F
N
L
F
P
-
H
M
T
V
L
N
N
I
T
L
A
P
----
M
K
V
R
K
W
P
R
E
K
A
E
A
--
K
A
M
E
L
L
D
K
V
GL
K
D
K
A
H
A
Y
P
D
S
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
S
V
M
K
Q
L
A
N
-
E
-
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
L
F
M
D
G
G
Y
I
I
E
E
G
K
P
E
D
L
F
D
R
P
Q
H
E
R
T
K
A
F
L
S
K
V
F
-
12
PsiBlast_PDB
85.94
32%
-88
- C1 -
4U00
3
?
A:
[5-238]
--------------------
I
R
I
R
N
L
H
K
W
---
F
G
P
L
H
V
L
K
G
I
H
L
E
V
A
P
G
E
K
L
V
I
I
G
P
S
G
S
G
K
S
T
L
I
R
T
I
N
R
L
E
D
F
Q
E
-----
G
E
V
V
V
D
G
L
S
V
K
-
D
-----------
D
R
A
L
R
E
I
R
R
E
V
G
M
V
F
Q
Q
F
N
L
F
P
-
H
M
T
V
L
E
N
V
T
L
A
P
M
R
V
R
R
W
P
R
E
K
A
E
K
K
A
L
E
L
L
E
R
V
G
I
L
D
Q
A
--
R
----
K
Y
P
A
Q
L
S
G
G
Q
Q
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
D
V
M
R
D
L
-
A
-
Q
G
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
A
D
R
V
V
F
M
D
G
G
Q
I
V
E
E
G
R
P
E
E
I
F
T
R
P
K
E
E
R
T
R
S
F
L
Q
R
V
L
H
27
PsiBlast_CBE
85.43
36%
-89
- C1 -
2OLK
1
?
C:
[22-263]
--------------------
L
Q
M
I
D
V
H
Q
L
KKS
F
G
S
L
E
V
L
K
G
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
E
D
F
D
E
-----
G
E
I
I
I
D
G
I
N
L
K
A
K
-----------
D
T
N
L
N
K
V
R
E
E
V
G
M
V
F
Q
R
F
N
L
F
P
-
H
M
T
V
L
N
N
I
T
L
A
P
----
M
K
V
R
K
W
P
R
E
K
A
E
A
--
K
A
M
E
L
L
D
K
V
GL
K
D
K
A
H
A
Y
P
D
S
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
S
V
M
K
Q
L
A
N
-
E
-
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
L
F
M
D
G
G
Y
I
I
E
E
G
K
P
E
D
L
F
D
R
P
Q
H
E
R
T
K
A
F
L
S
K
V
F
-
34
PsiBlast_CBE
85.32
32%
-86
- C1 -
4U02
1
?
C:
[5-238]
--------------------
I
R
I
R
N
L
H
K
W
---
F
G
P
L
H
V
L
K
G
I
H
L
E
V
A
P
G
E
K
L
V
I
I
G
P
S
G
S
G
K
S
T
L
I
R
T
I
N
R
L
E
D
F
Q
E
-----
G
E
V
V
V
D
G
L
S
V
K
-
D
-----------
D
R
A
L
R
E
I
R
R
E
V
G
M
V
F
Q
Q
F
N
L
F
P
-
H
M
T
V
L
E
N
V
T
L
A
P
M
R
V
R
R
W
P
R
E
K
A
E
K
K
A
L
E
L
L
E
R
V
G
I
L
D
Q
A
--
R
----
K
Y
P
A
Q
L
S
G
G
Q
Q
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
D
V
M
R
D
L
-
A
-
Q
G
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
A
D
R
V
V
F
M
D
G
G
Q
I
V
E
E
G
R
P
E
E
I
F
T
R
P
K
E
E
R
T
R
S
F
L
Q
R
V
L
H
13
PsiBlast_PDB
84.20
32%
-84
- C1 -
4U02
1
?
A:
[5-238]
--------------------
I
R
I
R
N
L
H
K
W
---
F
G
P
L
H
V
L
K
G
I
H
L
E
V
A
P
G
E
K
L
V
I
I
G
P
S
G
S
G
K
S
T
L
I
R
T
I
N
R
L
E
D
F
Q
E
-----
G
E
V
V
V
D
G
L
S
V
K
-
D
-----------
D
R
A
L
R
E
I
R
R
E
V
G
M
V
F
Q
Q
F
N
L
F
P
-
H
M
T
V
L
E
N
V
T
L
A
P
M
R
V
R
R
W
P
R
E
K
A
E
K
K
A
L
E
L
L
E
R
V
G
I
L
D
Q
A
--
R
----
K
Y
P
A
Q
L
S
G
G
Q
Q
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
D
V
M
R
D
L
-
A
-
Q
G
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
A
D
R
V
V
F
M
D
G
G
Q
I
V
E
E
G
R
P
E
E
I
F
T
R
P
K
E
E
R
T
R
S
F
L
Q
R
V
L
H
35
PsiBlast_CBE
83.63
32%
-87
- C1 -
4U02
1
?
B:
[5-238]
--------------------
I
R
I
R
N
L
H
K
W
---
F
G
P
L
H
V
L
K
G
I
H
L
E
V
A
P
G
E
K
L
V
I
I
G
P
S
G
S
G
K
S
T
L
I
R
T
I
N
R
L
E
D
F
Q
E
-----
G
E
V
V
V
D
G
L
S
V
K
-
D
-----------
D
R
A
L
R
E
I
R
R
E
V
G
M
V
F
Q
Q
F
N
L
F
P
-
H
M
T
V
L
E
N
V
T
L
A
P
M
R
V
R
R
W
P
R
E
K
A
E
K
K
A
L
E
L
L
E
R
V
G
I
L
D
Q
A
--
R
----
K
Y
P
A
Q
L
S
G
G
Q
Q
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
D
V
M
R
D
L
-
A
-
Q
G
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
A
D
R
V
V
F
M
D
G
G
Q
I
V
E
E
G
R
P
E
E
I
F
T
R
P
K
E
E
R
T
R
S
F
L
Q
R
V
L
H
32
PsiBlast_CBE
82.89
34%
-94
- C1 -
4YMU
2
?
A:
[6-237]
------------------------
D
V
Y
K
N
---
F
G
S
L
E
V
L
K
G
V
T
L
K
V
N
K
G
E
V
V
V
I
I
G
P
S
G
S
G
K
S
T
L
L
R
C
I
N
L
L
E
E
P
-----
T
K
G
E
V
F
I
D
G
V
K
I
N
N
G
-----------
K
V
N
I
N
K
V
R
Q
K
V
G
M
V
F
Q
H
F
N
L
F
P
-
H
L
T
A
I
E
N
I
T
L
A
P
V
K
V
K
K
M
N
K
K
E
A
E
E
L
A
V
D
L
L
A
K
V
G
L
L
D
K
---
K
D
---
Q
Y
P
I
K
L
S
G
G
Q
K
Q
R
L
A
I
A
R
A
L
A
M
Q
P
E
V
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
K
E
V
L
N
V
M
K
Q
L
A
N
-
E
-
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
I
F
M
D
D
G
V
I
V
E
E
G
T
P
E
E
I
F
Y
R
A
K
N
E
R
T
R
E
F
L
S
K
I
L
-
22
PsiBlast_CBE
82.03
36%
-90
- C1 -
2Q0H
4
?
B:
[22-263]
--------------------
L
Q
M
I
D
V
H
Q
L
K
K
S
F
G
S
L
E
V
L
K
G
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
E
D
F
D
E
-----
G
E
I
I
I
D
G
I
N
L
K
A
K
-----------
D
T
N
L
N
K
V
R
E
E
V
G
M
V
F
Q
R
F
N
L
F
P
-
H
M
T
V
L
N
N
I
T
L
A
P
----
M
K
V
R
K
W
P
R
E
K
A
E
A
--
K
A
M
E
L
L
D
K
V
GL
K
D
K
A
H
A
Y
P
D
S
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
S
V
M
K
Q
L
A
N
-
E
-
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
L
F
M
D
G
G
Y
I
I
E
E
G
K
P
E
D
L
F
D
R
P
Q
H
E
R
T
K
A
F
L
S
K
V
F
-
2
PsiBlast_PDB
81.72
36%
-85
- C1 -
2OLK
1
?
A:
[22-263]
--------------------
L
Q
M
I
D
V
H
Q
L
K
K
S
F
G
S
L
E
V
L
K
G
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
E
D
F
D
E
-----
G
E
I
I
I
D
G
I
N
L
K
A
K
-----------
D
T
N
L
N
K
V
R
E
E
V
G
M
V
F
Q
R
F
N
L
F
P
-
H
M
T
V
L
N
N
I
T
L
A
P
----
M
K
V
R
K
W
P
R
E
K
A
E
A
--
K
A
M
E
L
L
D
K
V
GL
K
D
K
A
H
A
Y
P
D
S
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
S
V
M
K
Q
L
A
N
-
E
-
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
L
F
M
D
G
G
Y
I
I
E
E
G
K
P
E
D
L
F
D
R
P
Q
H
E
R
T
K
A
F
L
S
K
V
F
-
9
PsiBlast_PDB
81.17
34%
-93
- C1 -
4YMU
2
?
J:
[6-237]
------------------------
D
V
Y
K
N
---
F
G
S
L
E
V
L
K
G
V
T
L
K
V
N
K
G
E
V
V
V
I
I
G
P
S
G
S
G
K
S
T
L
L
R
C
I
N
L
L
E
E
P
-----
T
K
G
E
V
F
I
D
G
V
K
I
N
N
G
-----------
K
V
N
I
N
K
V
R
Q
K
V
G
M
V
F
Q
H
F
N
L
F
P
-
H
L
T
A
I
E
N
I
T
L
A
P
V
K
V
K
K
M
N
K
K
E
A
E
E
L
A
V
D
L
L
A
K
V
G
L
L
D
K
---
K
D
---
Q
Y
P
I
K
L
S
G
G
Q
K
Q
R
L
A
I
A
R
A
L
A
M
Q
P
E
V
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
K
E
V
L
N
V
M
K
Q
L
A
N
-
E
-
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
I
F
M
D
D
G
V
I
V
E
E
G
T
P
E
E
I
F
Y
R
A
K
N
E
R
T
R
E
F
L
S
K
I
L
-
31
PsiBlast_CBE
81.13
34%
-94
- C1 -
4YMV
1
?
A:
[6-237]
------------------------
D
V
Y
K
N
---
F
G
S
L
E
V
L
K
G
V
T
L
K
V
N
K
G
E
V
V
V
I
I
G
P
S
G
S
G
K
S
T
L
L
R
C
I
N
L
L
E
E
P
-----
T
K
G
E
V
F
I
D
G
V
K
I
N
N
G
-----------
K
V
N
I
N
K
V
R
Q
K
V
G
M
V
F
Q
H
F
N
L
F
P
-
H
L
T
A
I
E
N
I
T
L
A
P
V
K
V
K
K
M
N
K
K
E
A
E
E
L
A
V
D
L
L
A
K
V
G
L
L
D
K
---
K
D
---
Q
Y
P
I
K
L
S
G
G
Q
K
Q
R
L
A
I
A
R
A
L
A
M
Q
P
E
V
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
K
E
V
L
N
V
M
K
Q
L
A
N
-
E
-
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
I
F
M
D
D
G
V
I
V
E
E
G
T
P
E
E
I
F
Y
R
A
K
N
E
R
T
R
E
F
L
S
K
I
L
-
10
PsiBlast_PDB
80.26
34%
-97
- C1 -
4YMV
1
?
J:
[6-237]
------------------------
D
V
Y
K
N
---
F
G
S
L
E
V
L
K
G
V
T
L
K
V
N
K
G
E
V
V
V
I
I
G
P
S
G
S
G
K
S
T
L
L
R
C
I
N
L
L
E
E
P
-----
T
K
G
E
V
F
I
D
G
V
K
I
N
N
G
-----------
K
V
N
I
N
K
V
R
Q
K
V
G
M
V
F
Q
H
F
N
L
F
P
-
H
L
T
A
I
E
N
I
T
L
A
P
V
K
V
K
K
M
N
K
K
E
A
E
E
L
A
V
D
L
L
A
K
V
G
L
L
D
K
---
K
D
---
Q
Y
P
I
K
L
S
G
G
Q
K
Q
R
L
A
I
A
R
A
L
A
M
Q
P
E
V
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
K
E
V
L
N
V
M
K
Q
L
A
N
-
E
-
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
I
F
M
D
D
G
V
I
V
E
E
G
T
P
E
E
I
F
Y
R
A
K
N
E
R
T
R
E
F
L
S
K
I
L
-