@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : gbs1102: (2015-12-05 )
MKASHPKKIQKKLVQDLLSKKSLVGMALLGTVVQVCLTVYLPVLIGQAVDVVLSPHSMILLLPIMWKMIAVILANAIIQWINPLLYNRLIFHYVASLRKAVMEKLNLLPIAYLDKRGIGDLISRVTTDTEQLSNGLLMVFNQFFVGLLTILVTIFSMAKIDLLMLFLVLFLTPLSLFLARFIAKKSYHLYQNQTASRGRQTQFIEEMVSQESLIQAFSAQEESSNHFRTINQEYANFSQSAIFYSSTVNPSTRFINSLIYGFLAGIGALRIMSGAFSVGQLITFLNYVNQYTKPFNDISSVLSEMQSALACAERLYSILEESSPNITGTEKLDSSTVKGQIDFKNVVFGYNKSKPLLNGINLHIPAGAKVAIVGPTGAGKSTLINLLMRFYEVDGGNILLDGKPITDYEPSQLRQEIGMVLQETWLKSATIHDNIAYANPKASRDEVIEAAKAANADFFIKQLPNGYDTYLEDAGDSLSQGQCQLLTIARIFLKLPRILILDEATSSIDTRTEVLVQEAFQMLMKGRTSFIIAHRLSTIQTADIILVMVSGEIVEVGNHSELIAQKGIYYQMQNAQK
Atome Classification :
(47 SA)
.........10........20.-.......30........40........50......--.---.60--.........70........80........90....---------....100.......110..--.....120...--....--------130---.......140.......-150.......160.......170.......180.....-..190------.....------..200.......210.......220.......230.......240.......250....-...-260-........270-......-------.280........290.------......300.......310.......----320......--.330--.--.-...-....340.......350...--.-.---....360.......370.......380.......390..---.....400.......410.......420.......430.....-.--.440---.-.......450.......460.......470.......480.......490.......500.......510.-......520..--.-----....530.......540.......550.......560...--.-...---570.....-
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MKAS
H
P
K
K
I
Q
K
K
L
V
Q
D
L
L
SK
K
S
-
L
V
G
M
A
L
L
G
T
V
V
Q
V
C
L
T
V
Y
L
P
V
L
I
G
Q
A
V
D
V
V
LSPH
S
--
M
---
I
L
---
L
L
P
I
M
W
K
M
I
A
V
I
L
A
N
A
I
I
Q
W
I
N
P
L
L
Y
N
R
L
I
F
H
Y
V
A
---------
S
L
R
K
A
V
M
E
KLNLL
P
I
A
Y
LD--KR
G
I
G
D
L
I
S
R
V--TT
D
T
--------
E
Q
L---SN
G
L
L
M
V
F
N
Q
F
F
V
G
L
L
T
-
I
L
V
T
I
F
S
M
A
K
I
D
L
L
M
L
F
L
V
L
F
L
T
P
L
S
L
F
L
A
R
F
I
A
K
K
S
Y
-
H
L
YQN------QTASR------G
R
Q
T
Q
F
I
E
E
M
V
S
Q
E
S
L
I
Q
A
F
SAQEESSN
H
F
R
T
I
N
Q
E
Y
ANFSQ
S
A
I
F
Y
SSTV
N
P
S
T
R
F
I
N
-
S
L
I
-
Y
G
--
F
L
A
G
I
G
A
L
R
I
M
-S
G
A
F
S
V
-------
G
Q
-
L
I
T
F
L
N
Y
V
N
Q
YTK------
P
F
N
D
I
S
S
V
L
S
E
M
Q
S
A
L
A
C
A
E
R
L
Y
S
I
L
----
E
ESSPNITG--TE----K--L-DSS-TV
K
G
Q
I
DFK
N
V
V
FGY--NKS--K-P---LLNGI
N
L
HIPAG
A
K
V
A
I
V
GPTGA
G
K
S
T
L
I
N
L
L
M
R
F
Y
EVD---G
G
N
I
L
LDGKPITDY
E
P
S
Q
L
R
Q
E
I
G
M
V
L
Q
E
T
WLKSATIHDNIAY-A--NP-K---A-
S
R
D
E
V
I
E
A
A
KAANAD
F
F
I
K
QLPN
G
Y
D
T
Y
L
E
DAGDSLSQG
Q
C
Q
L
L
T
I
A
R
I
F
L
KLP
R
I
L
I
LDEATSSI
D
T
R
T
E
-
V
L
V
Q
E
A
F
Q
M
L
M--K-----GR
T
S
F
I
I
A
HRLSTIQTA
D
I
I
L
V
M
VS
G
E
I
V
EVG
N
H
S
E
L
I
A
Q--K-
G
I
Y
---
Y
Q
MQNAQK-
1
PsiBlast_PDB
91.28
39%
-130
- C1 -
3QF4
1
Y288_THEMA
B:
[41-590]
--------------------------
M
V
F
V
F
V
T
V
S
S
I
L
G
V
L
S
P
Y
L
I
G
K
T
I
D
V
V
F
V
P
R
R
--
F
---
D
L
---
L
P
R
Y
M
L
I
L
G
T
I
Y
A
L
T
S
L
L
F
W
L
Q
G
K
I
M
L
T
L
S
Q
D
V
V
F
---------
R
L
R
K
E
L
F
E
K
L
Q
R
V
P
V
G
F
F
D
--
R
T
P
H
G
D
I
I
S
R
V
--
I
N
D
V
--------
D
N
I
---
N
N
V
L
G
N
S
I
I
Q
F
F
S
G
I
V
T
-
L
A
G
A
V
I
M
M
F
R
V
N
V
I
L
S
L
V
T
L
S
I
V
P
L
T
V
L
I
T
Q
I
V
S
S
Q
T
R
K
Y
F
Y
E
N
------
Q
R
V
L
-------
G
Q
L
N
G
I
I
E
E
D
I
S
G
L
T
V
I
K
L
F
T
R
E
E
K
E
M
E
K
F
D
R
V
N
E
S
L
R
K
V
G
T
K
A
Q
I
F
S
G
V
L
P
P
L
M
N
M
V
N
-
N
L
G
-
F
A
--
L
I
S
G
F
G
G
W
L
A
L
-
K
D
I
I
T
V
-------
G
T
-
I
A
T
F
I
G
Y
S
R
Q
F
T
R
------
P
L
N
E
L
S
N
Q
F
N
M
I
Q
M
A
L
A
S
A
E
R
I
F
E
I
L
D
LE
E
E
K
D
D
P
D
-----------
A
--
V
-
E
L
R
-
E
V
R
G
E
I
E
F
K
N
V
W
F
S
Y
--
D
K
K
--
K
-
P
---
V
L
K
D
I
T
F
H
I
K
P
G
Q
K
V
A
L
V
G
P
T
G
S
G
K
T
T
I
V
N
L
L
M
R
F
Y
D
V
D
---
R
G
Q
I
L
V
D
G
I
D
I
R
K
I
K
R
S
S
L
R
S
S
I
G
I
V
L
Q
D
T
I
L
F
S
T
T
V
K
E
N
L
K
Y
-
G
--
N
P
-
G
---
A
-
T
D
E
E
I
K
E
A
A
K
L
T
H
S
D
H
F
I
K
H
L
P
E
G
Y
E
T
V
L
T
D
N
G
E
D
L
S
Q
G
Q
R
Q
L
L
A
I
T
R
A
F
L
A
N
P
K
I
L
I
L
D
E
A
T
S
N
V
D
T
K
T
E
-
K
S
I
Q
A
A
M
W
K
L
M
--
E
-----
G
K
T
S
I
I
I
A
H
R
L
N
T
I
K
N
A
D
L
I
I
V
L
R
D
G
E
I
V
E
M
G
K
H
D
E
L
I
Q
K
--
R
-
G
F
Y
---
Y
E
L
F
T
S
Q
Y
-
4
PsiBlast_PDB
90.59
39%
-130
- C1 -
4Q4J
-
Y288_THEMA
B:
[41-590]
--------------------------
M
V
F
V
F
V
T
V
S
S
I
L
G
V
L
S
P
Y
L
I
G
K
T
I
D
V
V
F
V
P
R
R
--
F
---
D
L
---
L
P
R
Y
M
L
I
L
G
T
I
Y
A
L
T
S
L
L
F
W
L
Q
G
K
I
M
L
T
L
S
Q
D
V
V
F
---------
R
L
R
K
E
L
F
E
K
L
Q
R
V
P
V
G
F
F
D
--
R
T
P
H
G
D
I
I
S
R
V
--
I
N
D
V
--------
D
N
I
---
N
N
V
L
G
N
S
I
I
Q
F
F
S
G
I
V
T
-
L
A
G
A
V
I
M
M
F
R
V
N
V
I
L
S
L
V
T
L
S
I
V
P
L
T
V
L
I
T
Q
I
V
S
S
Q
T
R
K
Y
F
Y
E
N
------
Q
R
V
L
-------
G
Q
L
N
G
I
I
E
E
D
I
S
G
L
T
V
I
K
L
F
T
R
E
E
K
E
M
E
K
F
D
R
V
N
E
S
L
R
K
V
G
T
K
A
Q
I
F
S
G
V
L
P
P
L
M
N
M
V
N
-
N
L
G
-
F
A
--
L
I
S
G
F
G
G
W
L
A
L
-
K
D
I
I
T
V
-------
G
T
-
I
A
T
F
I
G
Y
S
R
Q
F
T
R
------
P
L
N
E
L
S
N
Q
F
N
M
I
Q
M
A
L
A
S
A
E
R
I
F
E
I
L
D
LEE
E
K
D
D
P
D
-----------
A
--
V
-
E
L
R
-
E
V
R
G
E
I
E
F
K
N
V
W
F
S
Y
--
D
K
K
--
K
-
P
---
V
L
K
D
I
T
F
H
I
K
P
G
Q
K
V
A
L
V
G
P
T
G
S
G
K
T
T
I
V
N
L
L
M
R
F
Y
D
V
D
---
R
G
Q
I
L
V
D
G
I
D
I
R
K
I
K
R
S
S
L
R
S
S
I
G
I
V
L
Q
D
T
I
L
F
S
T
T
V
K
E
N
L
K
Y
-
G
--
N
P
-
G
---
A
-
T
D
E
E
I
K
E
A
A
K
L
T
H
S
D
H
F
I
K
H
L
P
E
G
Y
E
T
V
L
T
D
N
G
E
D
L
S
Q
G
Q
R
Q
L
L
A
I
T
R
A
F
L
A
N
P
K
I
L
I
L
D
E
A
T
C
N
V
D
T
K
T
E
-
K
S
I
Q
A
A
M
W
K
L
M
--
E
-----
G
K
T
S
I
I
I
A
H
R
L
N
T
I
K
N
A
D
L
I
I
V
L
R
D
G
E
I
V
E
M
G
K
H
D
E
L
I
Q
K
--
R
-
G
F
Y
---
Y
E
L
F
T
S
Q
Y
-
3
PsiBlast_PDB
90.37
39%
-128
- C1 -
4Q4H
-
Y288_THEMA
B:
[41-590]
--------------------------
M
V
F
V
F
V
T
V
S
S
I
L
G
V
L
S
P
Y
L
I
G
K
T
I
D
V
V
F
V
P
R
R
--
F
---
D
L
---
L
P
R
Y
M
L
I
L
G
T
I
Y
A
L
T
S
L
L
F
W
L
Q
G
K
I
M
L
T
L
S
Q
D
V
V
F
---------
R
L
R
K
E
L
F
E
K
L
Q
R
V
P
V
G
F
F
D
--
R
T
P
H
G
D
I
I
S
R
V
--
I
N
D
V
--------
D
N
I
---
N
N
V
L
G
N
S
I
I
Q
F
F
S
G
I
V
T
-
L
A
G
A
V
I
M
M
F
R
V
N
V
I
L
S
L
V
T
L
S
I
V
P
L
T
V
L
I
T
Q
I
V
S
S
Q
T
R
K
Y
F
Y
E
N
------
Q
R
V
L
-------
G
Q
L
N
G
I
I
E
E
D
I
S
G
L
T
V
I
K
L
F
T
R
E
E
K
E
M
E
K
F
D
R
V
N
E
S
L
R
K
V
G
T
K
A
Q
I
F
S
G
V
L
P
P
L
M
N
M
V
N
-
N
L
G
-
F
A
--
L
I
S
G
F
G
G
W
L
A
L
-
K
D
I
I
T
V
-------
G
T
-
I
A
T
F
I
G
Y
S
R
Q
F
T
R
------
P
L
N
E
L
S
N
Q
F
N
M
I
Q
M
A
L
A
S
A
E
R
I
F
E
I
L
D
L
E
E
E
K
D
D
P
D
-----------
A
--
V
-
E
L
R
-
E
V
R
G
E
I
E
F
K
N
V
W
F
S
Y
--
D
K
K
--
K
-
P
---
V
L
K
D
I
T
F
H
I
K
P
G
Q
K
V
A
L
V
G
P
T
G
S
G
K
T
T
I
V
N
L
L
M
R
F
Y
D
V
D
---
R
G
Q
I
L
V
D
G
I
D
I
R
K
I
K
R
S
S
L
R
S
S
I
G
I
V
L
Q
D
T
I
L
F
S
T
T
V
K
E
N
L
K
Y
-
G
--
N
P
-
G
---
A
-
T
D
E
E
I
K
E
A
A
K
L
T
H
S
D
H
F
I
K
H
L
P
E
G
Y
E
T
V
L
T
D
N
G
E
D
L
S
Q
G
Q
R
Q
L
L
A
I
T
R
A
F
L
A
N
P
K
I
L
I
L
D
E
A
T
S
N
V
D
T
K
T
E
-
K
S
I
Q
A
A
M
W
K
L
M
--
E
-----
G
K
T
S
I
I
I
A
H
R
L
N
T
I
K
N
A
D
L
I
I
V
L
R
D
G
E
I
V
E
M
G
K
H
D
E
L
I
Q
K
--
R
-
G
F
Y
---
Y
E
L
F
T
S
Q
Y
-
2
PsiBlast_PDB
90.05
39%
-131
- C1 -
4Q4A
1
Y288_THEMA
B:
[41-590]
--------------------------
M
V
F
V
F
V
T
V
S
S
I
L
G
V
L
S
P
Y
L
I
G
K
T
I
D
V
V
F
V
P
R
R
--
F
---
D
L
---
L
P
R
Y
M
L
I
L
G
T
I
Y
A
L
T
S
L
L
F
W
L
Q
G
K
I
M
L
T
L
S
Q
D
V
V
F
---------
R
L
R
K
E
L
F
E
K
L
Q
R
V
P
V
G
F
F
D
--
R
T
P
H
G
D
I
I
S
R
V
--
I
N
D
V
--------
D
N
I
---
N
N
V
L
G
N
S
I
I
Q
F
F
S
G
I
V
T
-
L
A
G
A
V
I
M
M
F
R
V
N
V
I
L
S
L
V
T
L
S
I
V
P
L
T
V
L
I
T
Q
I
V
S
S
Q
T
R
K
Y
F
Y
E
N
------
Q
R
V
L
-------
G
Q
L
N
G
I
I
E
E
D
I
S
G
L
T
V
I
K
L
F
T
R
E
E
K
E
M
E
K
F
D
R
V
N
E
S
L
R
K
V
G
T
K
A
Q
I
F
S
G
V
L
P
P
L
M
N
M
V
N
-
N
L
G
-
F
A
--
L
I
S
G
F
G
G
W
L
A
L
-
K
D
I
I
T
V
-------
G
T
-
I
A
T
F
I
G
Y
S
R
Q
F
T
R
------
P
L
N
E
L
S
N
Q
F
N
M
I
Q
M
A
L
A
S
A
E
R
I
F
E
I
L
D
LEE
E
K
D
D
P
D
-----------
A
--
V
-
E
L
R
-
E
V
R
G
E
I
E
F
K
N
V
W
F
S
Y
--
D
K
K
--
K
-
P
---
V
L
K
D
I
T
F
H
I
K
P
G
Q
K
V
A
L
V
G
P
T
G
S
G
K
T
T
I
V
N
L
L
M
R
F
Y
D
V
D
---
R
G
Q
I
L
V
D
G
I
D
I
R
K
I
K
R
S
S
L
R
S
S
I
G
I
V
L
Q
D
T
I
L
F
S
T
T
V
K
E
N
L
K
Y
-
G
--
N
P
-
G
---
A
-
T
D
E
E
I
K
E
A
A
K
L
T
H
S
D
H
F
I
K
H
L
P
E
G
Y
E
T
V
L
T
D
N
G
E
D
L
S
Q
G
Q
R
Q
L
L
A
I
T
R
A
F
L
A
N
P
K
I
L
I
L
D
E
A
T
S
N
V
D
T
K
T
E
-
K
S
I
Q
A
A
M
W
K
L
M
--
E
-----
G
K
T
S
I
I
I
A
H
R
L
N
T
I
K
N
A
D
L
I
I
V
L
R
D
G
E
I
V
E
M
G
K
H
D
E
L
I
Q
K
--
R
-
G
F
Y
---
Y
E
L
F
T
S
Q
Y
-
117
HHSearch
83.18
29%
-118
- C1 -
3WMG
6
?
A:
[14-595]
---------
A
R
R
I
F
A
L
A
W
S
S
S
A
T
M
I
V
I
G
F
I
A
S
I
L
E
G
A
T
L
P
A
F
A
I
V
F
G
R
M
F
Q
V
F
T
K
S
K
S
Q
I
E
---
G
E
---
T
W
K
Y
S
V
G
F
V
G
I
G
V
F
E
F
I
V
A
G
S
R
T
A
L
F
G
I
A
S
E
R
L
A
R
---------
D
L
R
V
A
A
F
S
N
L
V
E
Q
D
V
T
Y
F
D
--
R
R
K
A
G
E
L
G
G
K
L
--
N
N
D
V
--------
Q
V
I
---
Q
Y
S
F
S
K
-
L
G
A
V
L
F
N
L
A
Q
-
C
V
V
G
I
I
V
A
F
I
F
A
P
A
L
T
G
V
L
I
A
L
S
P
L
V
V
L
A
V
V
V
Q
M
I
E
M
S
-
G
N
T
K
R
------
S
S
E
A
Y
------
A
S
A
G
S
V
A
A
E
V
F
S
N
I
R
T
T
K
A
F
E
A
E
R
Y
E
T
Q
R
Y
G
S
K
L
D
P
L
Y
R
L
G
R
R
R
Y
I
S
D
G
L
F
F
G
L
S
M
L
V
I
-
F
C
V
-
Y
A
--
L
A
L
W
W
G
G
Q
L
I
A
-
R
G
S
L
N
L
-------
G
N
-
L
L
T
A
F
F
S
A
I
L
G
F
M
------
G
V
G
Q
A
A
Q
V
W
P
D
V
T
R
G
L
G
A
G
G
E
L
F
A
M
I
----
D
R
V
P
Q
Y
R
R
P
--
D
P
G
A
E
V
V
--
T
-
Q
P
L
-
V
L
K
Q
G
I
V
F
E
N
V
H
F
R
Y
--
P
T
R
MN
V
-
E
---
V
L
R
G
I
S
L
T
I
P
N
G
K
T
V
A
I
V
G
G
S
G
A
G
K
S
T
I
I
Q
L
L
M
R
F
Y
D
I
E
PQG
G
G
L
L
L
F
D
G
T
P
A
W
N
Y
D
F
H
A
L
R
S
Q
I
G
L
V
S
Q
E
P
V
L
F
S
G
T
I
R
D
N
I
L
Y
-
G
--
K
R
-
D
---
A
-
T
D
E
E
V
I
Q
A
L
R
E
A
N
A
Y
S
F
V
M
A
L
P
D
G
L
D
T
E
V
G
E
R
G
L
A
L
S
G
G
Q
K
Q
R
I
A
I
A
R
A
I
L
K
H
P
T
L
L
C
L
D
E
S
T
S
A
L
D
A
E
S
E
-
A
L
V
Q
E
A
L
D
R
M
M
A
S
D
-----
G
V
T
S
V
V
I
A
H
R
L
S
T
V
A
R
A
D
L
I
L
V
M
Q
D
G
V
V
V
E
Q
G
N
H
S
E
L
M
A
L
GP
S
-
G
F
Y
---
Y
Q
L
V
E
K
Q
L
-
116
HHSearch
81.89
31%
-112
- C1 -
3ZDQ
6
ABCBA_HUMAN
A:
[5-572]
-------
P
E
A
R
K
L
L
G
L
A
Y
P
E
R
R
-
R
L
A
A
A
V
G
F
L
T
M
S
S
V
I
S
M
S
A
P
F
F
L
G
K
I
I
D
V
I
Y
T
N
P
T
--
V
DY
S
D
N
---
L
T
R
L
C
L
G
L
S
A
V
F
L
C
G
A
A
A
N
A
I
R
V
Y
L
M
Q
T
S
G
Q
R
I
V
N
---------
R
L
R
T
S
L
F
S
S
I
L
R
Q
E
V
A
F
F
D
--
K
T
R
T
G
E
L
I
N
R
L
--
S
S
D
T
--------
A
L
L
---
G
R
S
V
T
E
N
L
S
D
G
L
R
A
G
A
Q
-
A
S
V
G
I
S
M
M
F
F
V
S
P
N
L
A
T
F
V
L
S
V
V
P
P
V
S
I
I
A
V
I
Y
G
R
Y
L
R
-
K
L
T
K
V
------
T
Q
D
S
L
------
A
Q
A
T
Q
L
A
E
E
R
I
G
N
V
R
T
V
R
A
F
G
K
E
M
T
E
I
E
K
Y
A
S
K
V
D
H
V
M
Q
L
A
R
K
E
A
F
A
R
A
G
F
F
G
A
T
G
L
S
G
-
N
L
I
-
V
L
--
S
V
L
Y
K
G
G
L
L
M
G
-
S
A
H
M
T
V
-------
G
E
-
L
S
S
F
L
M
Y
A
F
W
V
G
I
------
S
I
G
G
L
S
S
F
Y
S
E
L
M
K
G
L
G
A
G
G
R
L
W
E
L
L
----
E
R
E
P
K
L
P
F
N
--
E
G
----
V
--
I
L
N
E
K
-
S
F
Q
G
A
L
E
F
K
N
V
H
F
A
Y
--
P
A
R
PE
V
-
P
---
I
F
Q
D
F
S
L
S
I
P
S
G
S
V
T
A
L
V
G
P
S
G
S
G
K
S
T
V
L
S
L
L
L
R
L
Y
D
P
A
---
S
G
T
I
S
L
D
G
H
D
I
R
Q
L
N
P
V
W
L
R
S
K
I
G
T
V
S
Q
E
P
I
L
F
S
C
S
I
A
E
N
I
A
Y
-
G
--
A
D
-
D
PSS
V
-
T
A
E
E
I
Q
R
V
A
E
V
A
N
A
V
A
F
I
R
N
F
P
Q
G
F
N
T
V
V
G
E
K
G
V
L
L
S
G
G
Q
K
Q
R
I
A
I
A
R
A
L
L
K
N
P
K
I
L
L
L
D
E
A
T
S
A
L
D
A
E
N
E
-
Y
L
V
Q
E
A
L
D
R
L
M
--
D
-----
G
R
T
V
L
V
I
A
H
R
L
S
T
I
K
N
A
N
M
V
A
V
L
D
Q
G
K
I
T
E
Y
G
K
H
E
E
L
L
S
K
P------------------
5
PsiBlast_PDB
80.63
33%
-117
- C1 -
2HYD
3
Y1866_STAAM
A:
[3-577]
----------
K
R
Y
L
Q
F
V
K
P
Y
K
Y
-
R
I
F
A
T
I
I
V
G
I
I
K
F
G
I
P
M
L
I
P
L
L
I
K
Y
A
I
D
G
V
I
N
N
H
A
--
L
---
T
T
---
D
E
K
V
H
H
L
T
I
A
I
G
I
A
L
F
I
F
V
I
V
R
P
P
I
--
E
F
I
R
Q
Y
L
A
Q
W
T
S
N
K
I
L
Y
D
I
R
K
K
L
Y
N
H
L
Q
A
L
S
A
R
F
Y
A
--
N
N
Q
V
G
Q
V
I
S
R
V
--
I
N
D
V
--------
E
Q
T
---
K
D
F
I
L
T
G
L
M
N
I
W
L
D
C
I
T
-
I
I
I
A
L
S
I
M
F
F
L
D
V
K
L
T
L
A
A
L
F
I
F
P
F
Y
I
L
T
V
Y
V
F
F
G
R
L
R
-
K
L
T
R
E
------
R
S
Q
A
L
------
A
E
V
Q
G
F
L
H
E
R
V
Q
G
I
S
V
V
K
S
F
A
I
E
D
N
E
A
K
N
F
---
D
K
K
N
T
N
F
L
T
R
A
L
K
H
T
R
W
N
A
Y
S
F
A
A
I
N
-
T
V
T
D
I
G
P
I
I
V
I
G
V
G
A
Y
L
A
I
-
S
G
S
I
T
V
-------
G
T
-
L
A
A
F
V
G
Y
L
E
L
L
F
G
------
P
L
R
R
L
V
A
S
F
T
T
L
T
Q
S
F
A
S
M
D
R
V
F
Q
L
I
----
D
E
D
Y
D
I
K
N
G
--
V
G
----
A
--
Q
-
P
I
E
-
I
K
Q
G
R
I
D
I
D
H
V
S
F
Q
Y
--
N
D
N
--
E
A
P
---
I
L
K
D
I
N
L
S
I
E
K
G
E
T
V
A
F
V
G
M
S
G
G
G
K
S
T
L
I
N
L
I
P
R
F
Y
D
V
T
---
S
G
Q
I
L
I
D
G
H
N
I
K
D
F
L
T
G
S
L
R
N
Q
I
G
L
V
Q
Q
D
N
I
L
F
S
D
T
V
K
E
N
I
L
L
-
G
--
R
P
-
T
---
A
-
T
D
E
E
V
V
E
A
A
K
M
A
N
A
H
D
F
I
M
N
L
P
Q
G
Y
D
T
E
V
G
E
R
G
V
K
L
S
G
G
Q
K
Q
R
L
S
I
A
R
I
F
L
N
N
P
P
I
L
I
L
D
E
A
T
S
A
L
D
L
E
S
E
-
S
I
I
Q
E
A
L
D
V
L
S
--
K
-----
D
R
T
T
L
I
V
A
H
R
L
S
T
I
T
H
A
D
K
I
V
V
I
E
N
G
H
I
V
E
T
G
T
H
R
E
L
I
A
K
--
Q
-
G
A
Y
E
H
L
Y
S
I
Q
N
L
---
6
PsiBlast_PDB
80.46
33%
-116
- C1 -
2ONJ
4
Y1866_STAAM
A:
[3-577]
----------
K
R
Y
L
Q
F
V
K
P
Y
K
Y
-
R
I
F
A
T
I
I
V
G
I
I
K
F
G
I
P
M
L
I
P
L
L
I
K
Y
A
I
D
G
V
I
N
N
H
A
--
L
---
T
T
---
D
E
K
V
H
H
L
T
I
A
I
G
I
A
L
F
I
F
V
I
V
R
P
P
I
--
E
F
I
R
Q
Y
L
A
Q
W
T
S
N
K
I
L
Y
D
I
R
K
K
L
Y
N
H
L
Q
A
L
S
A
R
F
Y
A
--
N
N
Q
V
G
Q
V
I
S
R
V
--
I
N
D
V
--------
E
Q
T
---
K
D
F
I
L
T
G
L
M
N
I
W
L
D
C
I
T
-
I
I
I
A
L
S
I
M
F
F
L
D
V
K
L
T
L
A
A
L
F
I
F
P
F
Y
I
L
T
V
Y
V
F
F
G
R
L
R
-
K
L
T
R
E
------
R
S
Q
A
L
------
A
E
V
Q
G
F
L
H
E
R
V
Q
G
I
S
V
V
K
S
F
A
I
E
D
N
E
A
K
N
F
---
D
K
K
N
T
N
F
L
T
R
A
L
K
H
T
R
W
N
A
Y
S
F
A
A
I
N
-
T
V
T
D
I
G
P
I
I
V
I
G
V
G
A
Y
L
A
I
-
S
G
S
I
T
V
-------
G
T
-
L
A
A
F
V
G
Y
L
E
L
L
F
G
------
P
L
R
R
L
V
A
S
F
T
T
L
T
Q
S
F
A
S
M
D
R
V
F
Q
L
I
----
D
E
D
Y
D
I
K
N
G
--
V
G
----
A
--
Q
-
P
I
E
-
I
K
Q
G
R
I
D
I
D
H
V
S
F
Q
Y
--
N
D
N
--
E
A
P
---
I
L
K
D
I
N
L
S
I
E
K
G
E
T
V
A
F
V
G
M
S
G
G
G
K
S
T
L
I
N
L
I
P
R
F
Y
D
V
T
---
S
G
Q
I
L
I
D
G
H
N
I
K
D
F
L
T
G
S
L
R
N
Q
I
G
L
V
Q
Q
D
N
I
L
F
S
D
T
V
K
E
N
I
L
L
-
G
--
R
P
-
T
---
A
-
T
D
E
E
V
V
E
A
A
K
M
A
N
A
H
D
F
I
M
N
L
P
Q
G
Y
D
T
E
V
G
E
R
G
V
K
L
S
G
G
Q
K
Q
R
L
S
I
A
R
I
F
L
N
N
P
P
I
L
I
L
D
E
A
T
S
A
L
D
L
E
S
E
-
S
I
I
Q
E
A
L
D
V
L
S
--
K
-----
D
R
T
T
L
I
V
A
H
R
L
S
T
I
T
H
A
D
K
I
V
V
I
E
N
G
H
I
V
E
T
G
T
H
R
E
L
I
A
K
--
Q
-
G
A
Y
E
H
L
Y
S
I
Q
N
L
---
104
Fugue
79.61
30%
-111
- C1 -
3B60
2
MSBA_SALTY
A:
[10-581]
------
W
Q
T
F
R
R
L
W
P
T
I
A
P
F
K
A
-
G
L
I
V
A
G
I
A
L
I
L
N
A
A
S
D
T
F
M
L
S
L
L
K
P
L
L
D
D
G
F
G
K
T
D
--
R
---
S
V
---
L
L
W
M
P
L
V
V
I
G
L
M
I
L
R
G
I
T
S
Y
I
S
S
Y
C
I
S
W
V
S
G
K
V
V
M
---------
T
M
R
R
R
L
F
G
H
M
M
G
M
P
V
A
F
F
D
--
K
Q
S
T
G
T
L
L
S
R
I
--
T
Y
D
S
--------
E
Q
V
---
A
S
S
S
S
G
A
L
I
T
V
V
R
E
G
A
S
-
I
I
G
L
F
I
M
M
F
Y
Y
S
W
Q
L
S
I
I
L
V
V
L
A
P
I
V
S
I
A
I
R
V
V
S
K
R
F
R
-
S
I
S
K
N
------
M
Q
N
T
M
------
G
Q
V
T
T
S
A
E
Q
M
L
K
G
H
K
E
V
L
I
F
G
G
Q
E
V
E
T
K
R
F
D
K
V
S
N
K
M
R
L
Q
G
M
K
M
V
S
A
S
S
I
S
D
P
I
I
Q
L
I
A
-
S
L
A
-
L
A
--
F
V
L
Y
A
A
S
F
P
S
V
-
M
D
S
L
T
A
-------
G
T
-
I
T
V
V
F
S
S
M
I
A
L
M
R
------
P
L
K
S
L
T
N
V
N
A
Q
F
Q
R
G
M
A
A
C
Q
T
L
F
A
I
L
----
D
S
E
Q
E
K
D
E
G
--
K
R
----
V
--
I
-
D
R
---
A
T
G
D
L
E
F
R
N
V
T
F
T
Y
P-
G
R
E
--
V
-
P
---
A
L
R
N
I
N
L
K
I
P
A
G
K
T
V
A
L
V
G
R
S
G
S
G
K
S
T
I
A
S
L
I
T
R
F
Y
D
I
D
---
E
G
H
I
L
M
D
G
H
D
L
R
E
Y
T
L
A
S
L
R
N
Q
V
A
L
V
S
Q
N
V
H
L
F
N
D
T
V
A
N
N
I
A
Y
-
A
--
R
T
E
E
---
Y
-
S
R
E
Q
I
E
E
A
A
R
M
A
Y
A
M
D
F
I
N
K
M
D
N
G
L
D
T
I
I
G
E
N
G
V
L
L
S
G
G
Q
R
Q
R
I
A
I
A
R
A
L
L
R
D
S
P
I
L
I
L
D
E
A
T
S
A
L
D
T
E
S
E
-
R
A
I
Q
A
A
L
D
E
L
Q
--
K
-----
N
R
T
S
L
V
I
A
H
R
L
S
T
I
E
Q
A
D
E
I
V
V
V
E
D
G
I
I
V
E
R
G
T
H
S
E
L
L
A
Q
--
H
-
G
V
Y
---
A
Q
L
H
K
M
Q
F
G
22
PsiBlast_CBE
79.37
33%
-116
- C1 -
2HYD
3
Y1866_STAAM
B:
[3-577]
----------
K
R
Y
L
Q
F
V
K
P
Y
K
Y
-
R
I
F
A
T
I
I
V
G
I
I
K
F
G
I
P
M
L
I
P
L
L
I
K
Y
A
I
D
G
V
I
N
N
H
A
--
L
---
T
T
---
D
E
K
V
H
H
L
T
I
A
I
G
I
A
L
F
I
F
V
I
V
R
P
P
I
--
E
F
I
R
Q
Y
L
A
QWTSNKILY
D
I
R
K
K
L
Y
N
H
L
Q
A
L
S
A
R
F
Y
A
--
N
N
Q
V
G
Q
V
I
S
R
V
--
I
N
D
V
--------
E
Q
T
---
K
D
F
I
L
T
G
L
M
N
I
W
L
D
C
I
T
-
I
I
I
A
L
S
I
M
F
F
L
D
V
K
L
T
L
A
A
L
F
I
F
P
F
Y
I
L
T
V
Y
V
F
F
G
R
L
R
-
K
L
T
R
E
------
R
S
Q
A
L
------
A
E
V
Q
G
F
L
H
E
R
V
Q
G
I
S
V
V
K
S
F
A
I
E
D
N
E
A
K
N
F
---
D
K
K
N
T
N
F
L
T
R
A
L
K
H
T
R
W
N
A
Y
S
F
A
A
I
N
-
T
V
T
D
I
G
PI
I
V
I
G
V
G
A
Y
L
A
I
-
S
G
S
I
T
V
-------
G
T
-
L
A
A
F
V
G
Y
L
E
L
L
F
G
------
P
L
R
R
L
V
A
S
F
T
T
L
T
Q
S
F
A
S
M
D
R
V
F
Q
L
I
----
D
E
D
Y
D
I
K
N
G
--
V
G
----
A
--
Q
-
P
I
E
-
I
K
Q
G
R
I
D
I
D
H
V
S
F
Q
Y
--
N
D
N
--
E
A
P
---
I
L
K
D
I
N
L
S
I
E
K
G
E
T
V
A
F
V
G
M
S
G
G
G
K
S
T
L
I
N
L
I
P
R
F
Y
D
V
T
---
S
G
Q
I
L
I
D
G
H
N
I
K
D
F
L
T
G
S
L
R
N
Q
I
G
L
V
Q
Q
D
N
I
L
F
S
D
T
V
K
E
N
I
L
L
-
G
--
R
P
-
T
---
A
-
T
D
E
E
V
V
E
A
A
K
M
A
N
A
H
D
F
I
M
N
L
P
Q
G
Y
D
T
E
V
G
E
R
G
V
K
L
S
G
G
Q
K
Q
R
L
S
I
A
R
I
F
L
N
N
P
P
I
L
I
L
D
E
A
T
S
A
L
D
L
E
S
E
-
S
I
I
Q
E
A
L
D
V
L
S
--
K
-----
D
R
T
T
L
I
V
A
H
R
L
S
T
I
T
H
A
D
K
I
V
V
I
E
N
G
H
I
V
E
T
G
T
H
R
E
L
I
A
K
--
Q
-
G
A
Y
EHL
Y
S
I
Q
N
L
---
114
HHSearch
79.31
30%
-110
- C1 -
3B60
2
MSBA_SALTY
A:
[10-579]
------
W
Q
T
F
R
R
L
W
P
T
I
A
P
F
K
A
-
G
L
I
V
A
G
I
A
L
I
L
N
A
A
S
D
T
F
M
L
S
L
L
K
P
L
L
D
D
G
F
G
K
T
D
--
R
---
S
V
---
L
L
W
M
P
L
V
V
I
G
L
M
I
L
R
G
I
T
S
Y
I
S
S
Y
C
I
S
W
V
S
G
K
V
V
M
---------
T
M
R
R
R
L
F
G
H
M
M
G
M
P
V
A
F
F
D
--
K
Q
S
T
G
T
L
L
S
R
I
--
T
Y
D
S
--------
E
Q
V
---
A
S
S
S
S
G
A
L
I
T
V
V
R
E
G
A
S
-
I
I
G
L
F
I
M
M
F
Y
Y
S
W
Q
L
S
I
I
L
V
V
L
A
P
I
V
S
I
A
I
R
V
V
S
K
R
F
R
-
S
I
S
K
N
------
M
Q
N
T
M
------
G
Q
V
T
T
S
A
E
Q
M
L
K
G
H
K
E
V
L
I
F
G
G
Q
E
V
E
T
K
R
F
D
K
V
S
N
K
M
R
L
Q
G
M
K
M
V
S
A
S
S
I
S
D
P
I
I
Q
L
I
A
-
S
L
A
-
L
A
--
F
V
L
Y
A
A
S
F
P
S
V
-
M
D
S
L
T
A
-------
G
T
-
I
T
V
V
F
S
S
M
I
A
L
M
R
------
P
L
K
S
L
T
N
V
N
A
Q
F
Q
R
G
M
A
A
C
Q
T
L
F
A
I
L
----
D
S
E
Q
E
K
D
E
G
--
K
--------
R
-
V
I
D
-
R
A
T
G
D
L
E
F
R
N
V
T
F
T
Y
--
P
G
R
E-
V
-
P
---
A
L
R
N
I
N
L
K
I
P
A
G
K
T
V
A
L
V
G
R
S
G
S
G
K
S
T
I
A
S
L
I
T
R
F
Y
D
I
D
---
E
G
H
I
L
M
D
G
H
D
L
R
E
Y
T
L
A
S
L
R
N
Q
V
A
L
V
S
Q
N
V
H
L
F
N
D
T
V
A
N
N
I
A
Y
-
A
--
R
T
E
E
---
Y
-
S
R
E
Q
I
E
E
A
A
R
M
A
Y
A
M
D
F
I
N
K
M
D
N
G
L
D
T
I
I
G
E
N
G
V
L
L
S
G
G
Q
R
Q
R
I
A
I
A
R
A
L
L
R
D
S
P
I
L
I
L
D
E
A
T
S
A
L
D
T
E
S
E
-
R
A
I
Q
A
A
L
D
E
L
Q
--
K
-----
N
R
T
S
L
V
I
A
H
R
L
S
T
I
E
Q
A
D
E
I
V
V
V
E
D
G
I
I
V
E
R
G
T
H
S
E
L
L
A
Q
--
H
-
G
V
Y
---
A
Q
L
H
K
M
Q
F
-
21
PsiBlast_CBE
78.45
33%
-115
- C1 -
2ONJ
4
Y1866_STAAM
B:
[3-577]
----------
K
R
Y
L
Q
F
V
K
P
Y
K
Y
-
R
I
F
A
T
I
I
V
G
I
I
K
F
G
I
P
M
L
I
P
L
L
I
K
Y
A
I
D
G
V
I
N
N
H
A
--
L
---
T
T
---
D
E
K
V
H
H
L
T
I
A
I
G
I
A
L
F
I
F
V
I
V
R
P
P
I
--
E
F
I
R
Q
Y
L
A
QWTSNKILY
D
I
R
K
K
L
Y
N
H
L
Q
A
L
S
A
R
F
Y
A
--
N
N
Q
V
G
Q
V
I
S
R
V
--
I
N
D
V
--------
E
Q
T
---
K
D
F
I
L
T
G
L
M
N
I
W
L
D
C
I
T
-
I
I
I
A
L
S
I
M
F
F
L
D
V
K
L
T
L
A
A
L
F
I
F
P
F
Y
I
L
T
V
Y
V
F
F
G
R
L
R
-
K
L
T
R
E
------
R
S
Q
A
L
------
A
E
V
Q
G
F
L
H
E
R
V
Q
G
I
S
V
V
K
S
F
A
I
E
D
N
E
A
K
N
F
---
D
K
K
N
T
N
F
L
T
R
A
L
K
H
T
R
W
N
A
Y
S
F
A
A
I
N
-
T
V
T
D
I
G
PI
I
V
I
G
V
G
A
Y
L
A
I
-
S
G
S
I
T
V
-------
G
T
-
L
A
A
F
V
G
Y
L
E
L
L
F
G
------
P
L
R
R
L
V
A
S
F
T
T
L
T
Q
S
F
A
S
M
D
R
V
F
Q
L
I
----
D
E
D
Y
D
I
K
N
G
--
V
G
----
A
--
Q
-
P
I
E
-
I
K
Q
G
R
I
D
I
D
H
V
S
F
Q
Y
--
N
D
N
--
E
A
P
---
I
L
K
D
I
N
L
S
I
E
K
G
E
T
V
A
F
V
G
M
S
G
G
G
K
S
T
L
I
N
L
I
P
R
F
Y
D
V
T
---
S
G
Q
I
L
I
D
G
H
N
I
K
D
F
L
T
G
S
L
R
N
Q
I
G
L
V
Q
Q
D
N
I
L
F
S
D
T
V
K
E
N
I
L
L
-
G
--
R
P
-
T
---
A
-
T
D
E
E
V
V
E
A
A
K
M
A
N
A
H
D
F
I
M
N
L
P
Q
G
Y
D
T
E
V
G
E
R
G
V
K
L
S
G
G
Q
K
Q
R
L
S
I
A
R
I
F
L
N
N
P
P
I
L
I
L
D
E
A
T
S
A
L
D
L
E
S
E
-
S
I
I
Q
E
A
L
D
V
L
S
--
K
-----
D
R
T
T
L
I
V
A
H
R
L
S
T
I
T
H
A
D
K
I
V
V
I
E
N
G
H
I
V
E
T
G
T
H
R
E
L
I
A
K
--
Q
-
G
A
Y
EHL
Y
S
I
Q
N
L
---
16
PsiBlast_PDB
78.37
32%
-119
- C1 -
4AYX
7
ABCBA_HUMAN
A:
[39-574]
------------------------------------------
P
F
F
L
G
K
I
I
D
V
I
Y
T
N
P
T
--
V
---
D
Y
S
D
N
L
T
R
L
C
L
G
L
S
A
V
F
L
C
G
A
A
A
N
A
I
R
V
Y
L
M
Q
T
S
G
Q
R
I
V
N
---------
R
L
R
T
S
L
F
S
S
I
L
R
Q
E
V
A
F
F
D
--
K
T
R
T
G
E
L
I
N
R
L
--
S
S
D
T
A
L
L
G
R
S
V
T
E
N
L
---
S
D
G
L
-
R
A
G
A
Q
A
S
V
G
----
I
S
M
M
F
F
V
S
P
N
L
A
T
F
V
L
S
V
V
P
P
V
S
I
I
A
V
I
Y
G
R
Y
L
R
K
-----
L
T
K
V
------
T
Q
D
S
L
------
A
Q
A
T
Q
L
A
E
E
R
I
G
N
V
R
T
V
R
A
F
G
K
E
M
T
E
I
E
K
Y
A
S
K
V
D
H
V
M
Q
L
A
R
K
E
A
F
A
R
A
G
F
F
G
A
T
G
L
S
G
-
N
L
I
-
V
L
--
S
V
L
Y
K
G
G
L
L
M
G
-
S
A
H
M
T
V
-------
G
E
-
L
S
S
F
L
M
Y
A
F
W
V
G
I
------
S
I
G
G
L
S
S
F
Y
S
E
L
M
K
G
L
G
A
G
G
R
L
W
E
L
L
----
E
R
E
-
P
K
L
P
F
--
N
E
----
G
V
I
L
-
N
E
K
-
S
F
Q
G
A
L
E
F
K
N
V
H
F
A
Y
PA
R
P
E
--
V
-
P
---
I
F
Q
D
F
S
L
S
I
P
S
G
S
V
T
A
L
V
G
P
S
G
S
G
K
S
T
V
L
S
L
L
L
R
L
Y
D
P
A
---
S
G
T
I
S
L
D
G
H
D
I
R
Q
L
N
P
V
W
L
R
S
K
I
G
T
V
S
Q
E
P
I
L
F
S
C
S
I
A
E
N
I
A
Y
-
G
AD
D
P
-
S
---
S
V
T
A
E
E
I
Q
R
V
A
E
V
A
N
A
V
A
F
I
R
N
F
P
Q
G
F
N
T
V
V
G
E
K
G
V
L
L
S
G
G
Q
K
Q
R
I
A
I
A
R
A
L
L
K
N
P
K
I
L
L
L
D
E
A
T
S
A
L
D
A
E
N
E
-
Y
L
V
Q
E
A
L
D
R
L
M
--
D
-----
G
R
T
V
L
V
I
A
H
R
L
S
T
I
K
N
A
N
M
V
A
V
L
D
Q
G
K
I
T
E
Y
G
K
H
E
E
L
L
S
K
P-
N
-
G
--------------
19
PsiBlast_PDB
77.09
32%
-121
- C1 -
4AYW
3
ABCBA_HUMAN
A:
[65-598]
-------------------------------------
I
S
M
S
A
P
F
F
L
G
K
I
I
D
V
I
Y
T
N
P
T
--
V
---
D
Y
S
D
N
L
T
R
L
C
L
G
L
S
A
V
F
L
C
G
A
A
A
N
A
I
R
V
Y
L
M
Q
T
S
G
Q
R
I
V
N
---------
R
L
R
T
S
L
F
S
S
I
L
R
Q
E
V
A
F
F
D
--
K
T
R
T
G
E
L
I
N
R
L
--
S
S
D
T
A
L
L
G
R
S
V
T
E
N
L
---
S
D
G
L
-
R
A
G
A
Q
A
S
V
G
----
I
S
M
M
F
F
V
S
P
N
L
A
T
F
V
L
S
V
V
P
P
V
S
I
I
A
V
I
Y
G
R
Y
L
-
R
K
L
T
-
K
V
T
Q
D
------
S
L
A
---------
Q
A
T
Q
L
A
E
E
R
I
G
N
V
R
T
V
R
A
F
G
K
E
M
T
E
I
E
K
Y
A
S
K
V
D
H
V
M
Q
L
A
R
K
E
A
F
A
R
A
G
F
F
G
A
T
G
L
S
G
-
N
L
I
-
V
L
--
S
V
L
Y
K
G
G
L
L
M
G
-
S
A
H
M
T
V
-------
G
E
-
L
S
S
F
L
M
Y
A
F
W
V
G
I
------
S
I
G
G
L
S
S
F
Y
S
E
L
M
K
G
L
G
A
G
G
R
L
W
E
L
L
----
E
R
E
-
P
K
L
P
F
--
N
E
----
G
V
I
L
-
N
E
K
-
S
F
Q
G
A
L
E
F
K
N
V
H
F
A
Y
PA
R
P
E
--
V
-
P
---
I
F
Q
D
F
S
L
S
I
P
S
G
S
V
T
A
L
V
G
P
S
G
S
G
K
S
T
V
L
S
L
L
L
R
L
Y
D
P
A
---
S
G
T
I
S
L
D
G
H
D
I
R
Q
L
N
P
V
W
L
R
S
K
I
G
T
V
S
Q
E
P
I
L
F
S
C
S
I
A
E
N
I
A
Y
-
G
AD
D
P
-
S
---
S
V
T
A
E
E
I
Q
R
V
A
E
V
A
N
A
V
A
F
I
R
N
F
P
Q
G
F
N
T
V
V
G
E
K
G
V
L
L
S
G
G
Q
K
Q
R
I
A
I
A
R
A
L
L
K
N
P
K
I
L
L
L
D
E
----
L
D
A
E
N
E
-
Y
L
V
Q
E
A
L
D
R
L
M
--
D
-----
G
R
T
V
L
V
I
A
H
H
L
S
T
I
K
N
A
N
M
V
A
V
L
D
Q
G
K
I
T
E
Y
G
K
H
E
E
-----------------------
36
PsiBlast_CBE
76.99
33%
-107
- C1 -
4M1M
4
MDR1A_MOUSE
A:
[784-1270]
------------------------------------------------------------------------------------------------------------------
L
R
Y
M
V
F
K
S
M
L
R
Q
D
V
S
W
F
D
DP
K
N
T
T
G
A
L
T
T
R
L
--
A
N
D
A
--------
A
Q
V
K
G
A
T
G
S
R
L
A
V
I
F
Q
N
I
A
N
L
G
T
G
I
I
I
S
L
I
Y
G
W
Q
L
T
L
L
L
L
A
I
V
P
I
I
A
I
A
G
V
V
E
M
K
M
L
S
G
Q
A
L
-
K
D
K
K
E
------
L
E
G
S
G
------
K
I
A
T
E
A
I
E
N
F
R
T
V
V
S
L
T
R
E
---
Q
K
F
E
T
M
Y
A
Q
S
L
Q
I
P
Y
R
N
A
M
K
K
A
H
V
F
G
I
T
F
S
----
F
T
Q
-
A
M
M
-
Y
F
--
S
Y
A
A
--
A
F
R
F
---
G
A
Y
L
V
-------
T
Q
Q
L
M
T
F
E
N
V
L
L
V
F
S
A
I
V
F
G
A
M
A
V
G
Q
V
S
S
F
A
P
D
Y
A
K
A
T
V
S
A
S
H
I
I
R
I
I
----
E
K
T
-
P
E
I
D
S
YS
T
Q
----
G
--
L
-
K
P
N
-
M
L
E
G
N
V
Q
F
S
G
V
V
F
N
Y
PT
R
P
S
--
I
-
P
---
V
L
Q
G
L
S
L
E
V
K
K
G
Q
T
L
A
L
V
G
S
S
G
C
G
K
S
T
V
V
Q
L
L
E
R
F
Y
D
P
M
---
A
G
S
V
F
L
D
G
K
E
I
K
Q
L
N
V
Q
W
L
R
A
Q
L
G
I
V
S
Q
E
P
I
L
F
D
C
S
I
A
E
N
I
A
Y
-
G
--
D
N
-
S
RV-
V
-
S
Y
E
E
I
V
R
A
A
K
E
A
N
I
H
Q
F
I
D
S
L
P
D
K
Y
N
T
R
V
G
D
K
G
T
Q
L
S
G
G
Q
K
Q
R
I
A
I
A
R
A
L
V
R
Q
P
H
I
L
L
L
D
E
A
T
S
A
L
D
T
E
S
E
-
K
V
V
Q
E
A
L
D
K
A
R
--
E
-----
G
R
T
C
I
V
I
A
H
R
L
S
T
I
Q
N
A
D
L
I
V
V
I
Q
N
G
K
V
K
E
H
G
T
H
Q
Q
L
L
A
Q
--
K
-
G
I
Y
---
F
S
M
V
S
V
Q
A
-
17
PsiBlast_PDB
76.73
32%
-115
- C1 -
3ZDQ
6
ABCBA_HUMAN
A:
[39-572]
------------------------------------------
P
F
F
L
G
K
I
I
D
V
I
Y
T
N
P
T
--
V
---
D
Y
S
D
N
L
T
R
L
C
L
G
L
S
A
V
F
L
C
G
A
A
A
N
A
I
R
V
Y
L
M
Q
T
S
G
Q
R
I
V
N
---------
R
L
R
T
S
L
F
S
S
I
L
R
Q
E
V
A
F
F
D
--
K
T
R
T
G
E
L
I
N
R
L
--
S
S
D
T
A
L
L
G
R
S
V
T
E
N
L
---
S
D
G
L
-
R
A
G
A
Q
A
S
V
G
----
I
S
M
M
F
F
V
S
P
N
L
A
T
F
V
L
S
V
V
P
P
V
S
I
I
A
V
I
Y
G
R
Y
L
R
K
-----
L
T
K
V
------
T
Q
D
S
L
------
A
Q
A
T
Q
L
A
E
E
R
I
G
N
V
R
T
V
R
A
F
G
K
E
M
T
E
I
E
K
Y
A
S
K
V
D
H
V
M
Q
L
A
R
K
E
A
F
A
R
A
G
F
F
G
A
T
G
L
S
G
-
N
L
I
-
V
L
--
S
V
L
Y
K
G
G
L
L
M
G
-
S
A
H
M
T
V
-------
G
E
-
L
S
S
F
L
M
Y
A
F
W
V
G
I
------
S
I
G
G
L
S
S
F
Y
S
E
L
M
K
G
L
G
A
G
G
R
L
W
E
L
L
----
E
R
E
-
P
K
L
P
F
--
N
E
----
G
V
I
L
-
N
E
K
-
S
F
Q
G
A
L
E
F
K
N
V
H
F
A
Y
PA
R
P
E
--
V
-
P
---
I
F
Q
D
F
S
L
S
I
P
S
G
S
V
T
A
L
V
G
P
S
G
S
G
K
S
T
V
L
S
L
L
L
R
L
Y
D
P
A
---
S
G
T
I
S
L
D
G
H
D
I
R
Q
L
N
P
V
W
L
R
S
K
I
G
T
V
S
Q
E
P
I
L
F
S
C
S
I
A
E
N
I
A
Y
-
G
AD
D
P
-
S
---
S
V
T
A
E
E
I
Q
R
V
A
E
V
A
N
A
V
A
F
I
R
N
F
P
Q
G
F
N
T
V
V
G
E
K
G
V
L
L
S
G
G
Q
K
Q
R
I
A
I
A
R
A
L
L
K
N
P
K
I
L
L
L
D
E
A
T
S
A
L
D
A
E
N
E
-
Y
L
V
Q
E
A
L
D
R
L
M
--
D
-----
G
R
T
V
L
V
I
A
H
R
L
S
T
I
K
N
A
N
M
V
A
V
L
D
Q
G
K
I
T
E
Y
G
K
H
E
E
L
L
S
K
P------------------
45
PsiBlast_CBE
76.23
32%
-106
- C1 -
4M2T
2
MDR1A_MOUSE
A:
[784-1270]
------------------------------------------------------------------------------------------------------------------
L
R
Y
M
V
F
K
S
M
L
R
Q
D
V
S
W
F
D
DP
K
N
T
T
G
A
L
T
T
R
L
--
A
N
D
A
--------
A
Q
V
K
G
A
T
G
S
R
L
A
V
I
F
Q
N
I
A
N
L
G
T
G
I
I
I
S
L
I
Y
G
W
Q
L
T
L
L
L
L
A
I
V
P
I
I
A
I
A
G
V
V
E
M
K
M
L
S
G
Q
A
L
-
K
D
K
K
E
------
L
E
G
S
G
------
K
I
A
T
E
A
I
E
N
F
R
T
V
V
S
L
T
R
E
---
Q
K
F
E
T
M
Y
A
Q
S
L
Q
I
P
Y
R
N
A
M
K
K
A
H
V
F
G
I
T
F
S
----
F
T
Q
-
A
M
M
-
Y
F
--
S
Y
A
A
--
C
F
R
F
---
G
A
Y
L
V
-------
T
Q
Q
L
M
T
F
E
N
V
L
L
V
F
S
A
I
V
F
G
A
M
A
V
G
Q
V
S
S
F
A
P
D
Y
A
K
A
T
V
S
A
S
H
I
I
R
I
I
----
E
K
T
-
P
E
I
D
S
YS
T
Q
----
G
--
L
-
K
P
N
-
M
L
E
G
N
V
Q
F
S
G
V
V
F
N
Y
PT
R
P
S
--
I
-
P
---
V
L
Q
G
L
S
L
E
V
K
K
G
Q
T
L
A
L
V
G
S
S
G
C
G
K
S
T
V
V
Q
L
L
E
R
F
Y
D
P
M
---
A
G
S
V
F
L
D
G
K
E
I
K
Q
L
N
V
Q
W
L
R
A
Q
L
G
I
V
S
Q
E
P
I
L
F
D
C
S
I
A
E
N
I
A
Y
-
G
--
D
N
-
S
RV-
V
-
S
Y
E
E
I
V
R
A
A
K
E
A
N
I
H
Q
F
I
D
S
L
P
D
K
Y
N
T
R
V
G
D
K
G
T
Q
L
S
G
G
Q
K
Q
R
I
A
I
A
R
A
L
V
R
Q
P
H
I
L
L
L
D
E
A
T
S
A
L
D
T
E
S
E
-
K
V
V
Q
E
A
L
D
K
A
R
--
E
-----
G
R
T
C
I
V
I
A
H
R
L
S
T
I
Q
N
A
D
L
I
V
V
I
Q
N
G
K
V
K
E
H
G
T
H
Q
Q
L
L
A
Q
--
K
-
G
I
Y
---
F
S
M
V
S
V
Q
A
-
25
PsiBlast_CBE
76.07
32%
-111
- C1 -
3B60
2
MSBA_SALTY
B:
[59-579]
------------------------------------------------------
T
D
R
S
--
V
---
L
L
---
W
M
P
L
V
--
V
I
G
L
M
I
L
R
G
I
T
S
Y
I
S
S
Y
C
I
S
W
V
S
G
K
V
V
M
---------
T
M
R
R
R
L
F
G
H
M
M
G
M
P
V
A
F
F
D
--
K
Q
S
T
G
T
L
L
S
R
I
--
T
Y
D
S
--------
E
Q
V
ASS
S
S
G
A
L
I
T
V
V
R
E
G
A
S
I
I
G
-
L
F
I
M
M
F
Y
Y
S
---
W
Q
L
S
I
I
L
V
V
L
A
P
I
V
S
I
A
I
R
V
V
S
K
R
F
R
-
S
I
S
K
N
------
M
Q
N
T
M
------
G
Q
V
T
T
S
A
E
Q
M
L
K
G
H
K
E
V
L
I
F
G
G
Q
E
V
E
T
K
R
F
D
K
V
S
N
K
M
R
L
Q
G
M
K
M
V
S
A
S
S
I
S
D
P
I
I
Q
L
I
A
-
S
L
A
-
L
A
--
F
V
L
Y
A
A
S
F
P
S
V
-
M
D
S
L
T
A
-------
G
T
-
I
T
V
V
F
S
S
M
I
A
L
M
R
------
P
L
K
S
L
T
N
V
N
A
Q
F
Q
R
G
M
A
A
C
Q
T
L
F
A
I
L
----
D
S
E
Q
E
K
D
E
G
--
K
R
----
V
--
I
-
D
R
A
-
T
--
G
D
L
E
F
R
N
V
T
F
T
Y
P-
G
R
E
--
V
-
P
---
A
L
R
N
I
N
L
K
I
P
A
G
K
T
V
A
L
V
G
R
S
G
S
G
K
S
T
I
A
S
L
I
T
R
F
Y
D
I
D
---
E
G
H
I
L
M
D
G
H
D
L
R
E
Y
T
L
A
S
L
R
N
Q
V
A
L
V
S
Q
N
V
H
L
F
N
D
T
V
A
N
N
I
A
Y
-
A
--
R
T
-
E
---
E
Y
S
R
E
Q
I
E
E
A
A
R
M
A
Y
A
M
D
F
I
N
K
M
D
N
G
L
D
T
I
I
G
E
N
G
V
L
L
S
G
G
Q
R
Q
R
I
A
I
A
R
A
L
L
R
D
S
P
I
L
I
L
D
E
A
T
S
A
L
D
T
E
S
E
-
R
A
I
Q
A
A
L
D
E
L
Q
--
K
-----
N
R
T
S
L
V
I
A
H
R
L
S
T
I
E
Q
A
D
E
I
V
V
V
E
D
G
I
I
V
E
R
G
T
H
S
E
L
L
A
Q
--
H
-
G
V
Y
---
A
Q
L
H
K
M
Q
F
-
35
PsiBlast_CBE
75.98
33%
-106
- C1 -
4M1M
4
MDR1A_MOUSE
B:
[784-1270]
------------------------------------------------------------------------------------------------------------------
L
R
Y
M
V
F
K
S
M
L
R
Q
D
V
S
W
F
D
DP
K
N
T
T
G
A
L
T
T
R
L
--
A
N
D
A
--------
A
Q
V
KGA
T
G
S
R
L
A
V
I
F
Q
N
I
A
N
L
G
T
G
I
I
I
S
L
I
Y
G
W
Q
L
T
L
L
L
L
A
I
V
P
I
I
A
I
A
G
V
V
E
M
K
M
L
S
G
Q
A
L
-
K
D
K
K
E
------
L
E
G
S
G
------
K
I
A
T
E
A
I
E
N
F
R
T
V
V
S
L
T
R
E
---
Q
K
F
E
T
M
Y
A
Q
S
L
Q
I
P
Y
R
N
A
M
K
K
A
H
V
F
G
I
T
F
S
----
F
T
Q
-
A
M
M
-
Y
F
--
S
Y
A
A
--
A
F
R
F
---
G
A
Y
L
V
-------
T
Q
Q
L
M
T
F
E
N
V
L
L
V
F
S
A
I
V
F
G
A
M
A
V
G
Q
V
S
S
F
A
P
D
Y
A
K
A
T
V
S
A
S
H
I
I
R
I
I
----
E
K
T
-
P
E
I
D
S
YS
T
Q
----
G
--
L
-
K
P
N
-
M
L
E
G
N
V
Q
F
S
G
V
V
F
N
Y
PT
R
P
S
--
I
-
P
---
V
L
Q
G
L
S
L
E
V
K
K
G
Q
T
L
A
L
V
G
S
S
G
C
G
K
S
T
V
V
Q
L
L
E
R
F
Y
D
P
M
---
A
G
S
V
F
L
D
G
K
E
I
K
Q
L
N
V
Q
W
L
R
A
Q
L
G
I
V
S
Q
E
P
I
L
F
D
C
S
I
A
E
N
I
A
Y
-
G
--
D
N
-
S
RV-
V
-
S
Y
E
E
I
V
R
A
A
K
E
A
N
I
H
Q
F
I
D
S
L
P
D
K
Y
N
T
R
V
G
D
K
G
T
Q
L
S
G
G
Q
K
Q
R
I
A
I
A
R
A
L
V
R
Q
P
H
I
L
L
L
D
E
A
T
S
A
L
D
T
E
S
E
-
K
V
V
Q
E
A
L
D
K
A
R
--
E
-----
G
R
T
C
I
V
I
A
H
R
L
S
T
I
Q
N
A
D
L
I
V
V
I
Q
N
G
K
V
K
E
H
G
T
H
Q
Q
L
L
A
Q
--
K
-
G
I
Y
---
F
S
M
V
S
V
Q
A
-
15
PsiBlast_PDB
75.93
32%
-116
- C1 -
4AYT
8
ABCBA_HUMAN
A:
[39-567]
------------------------------------------
P
F
F
L
G
K
I
I
D
V
I
Y
T
N
P
T
--
V
---
D
Y
S
D
N
L
T
R
L
C
L
G
L
S
A
V
F
L
C
G
A
A
A
N
A
I
R
V
Y
L
M
Q
T
S
G
Q
R
I
V
N
---------
R
L
R
T
S
L
F
S
S
I
L
R
Q
E
V
A
F
F
D
--
K
T
R
T
G
E
L
I
N
R
L
--
S
S
D
T
A
L
L
G
R
S
V
T
E
N
L
---
S
D
G
L
-
R
A
G
A
Q
A
S
V
G
----
I
S
M
M
F
F
V
S
P
N
L
A
T
F
V
L
S
V
V
P
P
V
S
I
I
A
V
I
Y
G
R
Y
L
R
K
-----
L
T
K
V
------
T
Q
D
S
L
------
A
Q
A
T
Q
L
A
E
E
R
I
G
N
V
R
T
V
R
A
F
G
K
E
M
T
E
I
E
K
Y
A
S
K
V
D
H
V
M
Q
L
A
R
K
E
A
F
A
R
A
G
F
F
G
A
T
G
L
S
G
-
N
L
I
-
V
L
--
S
V
L
Y
K
G
G
L
L
M
G
-
S
A
H
M
T
V
-------
G
E
-
L
S
S
F
L
M
Y
A
F
W
V
G
I
------
S
I
G
G
L
S
S
F
Y
S
E
L
M
K
G
L
G
A
G
G
R
L
W
E
L
L
----
E
R
E
-
P
K
L
P
F
--
N
E
----
G
V
I
L
-
N
E
K
-
S
F
Q
G
A
L
E
F
K
N
V
H
F
A
Y
PA
R
P
E
--
V
-
P
---
I
F
Q
D
F
S
L
S
I
P
S
G
S
V
T
A
L
V
G
P
S
G
S
G
K
S
T
V
L
S
L
L
L
R
L
Y
D
P
A
---
S
G
T
I
S
L
D
G
H
D
I
R
Q
L
N
P
V
W
L
R
S
K
I
G
T
V
S
Q
E
P
I
L
F
S
C
S
I
A
E
N
I
A
Y
-
G
AD
D
P
-
S
---
S
V
T
A
E
E
I
Q
R
V
A
E
V
A
N
A
V
A
F
I
R
N
F
P
Q
G
F
N
T
V
V
G
E
K
G
V
L
L
S
G
G
Q
K
Q
R
I
A
I
A
R
A
L
L
K
N
P
K
I
L
L
L
D
E
A
T
S
A
L
D
A
E
N
E
-
Y
L
V
Q
E
A
L
D
R
L
M
--
D
-----
G
R
T
V
L
V
I
A
H
R
L
S
T
I
K
N
A
N
M
V
A
V
L
D
Q
G
K
I
T
E
Y
G
K
H
E
E
-----------------------
20
PsiBlast_PDB
64.06
35%
-88
- C1 -
4S0F
2
?
A:
[256-720]
-----------------------------------------------------------------------------------------------------------------------------
L
P
M
N
F
F
N
--
S
R
K
V
G
E
I
I
S
R
F
M
D
A
S
K
I
--------
R
Q
A
---
I
S
G
----------
A
T
L
T
-
I
M
I
D
T
I
-
M
A
V
I
G
G
I
L
L
Y
I
----
Q
N
S
S
L
F
F
I
S
F
I
I
I
L
L
Y
-
G
I
I
V
T
V
F
N
K
P
I
Q
N
A
N
R
Q
I
M
E
D
N
A
K
L
T
S
A
L
V
E
S
V
K
G
I
E
T
I
K
S
F
G
A
E
E
Q
T
E
K
S
T
R
---------
D
K
I
E
T
V
M
K
S
S
F
K
E
G
M
L
Y
I
N
L
S
S
L
-
T
G
--
I
V
A
G
L
G
G
I
V
I
L
W
A
G
A
Y
N
V
I
K
GNMS
G
G
Q
-
L
L
A
F
N
A
L
L
A
Y
F
L
T
------
P
V
K
N
L
I
D
L
Q
P
L
I
Q
T
A
V
V
A
S
N
R
L
G
E
I
L
----
E
L
A
T
E
K
E
L
R
--
E
D
----
S
--
D
-
D
F
V
I
S
L
K
G
D
I
E
F
R
N
V
D
F
R
Y
--
G
L
R
--
K
-
P
---
V
L
K
N
I
N
L
T
I
P
K
G
K
T
V
A
I
V
G
E
S
G
S
G
K
T
T
L
A
K
L
L
M
N
F
Y
S
P
E
---
K
G
D
I
L
I
N
G
H
S
I
K
N
I
S
L
E
L
I
R
K
K
I
A
F
V
S
Q
D
V
F
I
F
S
G
T
V
K
E
N
L
C
L
-
G
--
N
E
-
N
---
V
-
D
M
D
E
I
I
K
A
A
K
M
A
N
A
H
D
F
I
E
K
L
P
L
K
Y
D
T
F
L
N
E
S
G
A
N
L
S
E
G
Q
K
Q
R
L
A
I
A
R
A
L
L
K
K
P
D
I
L
I
L
D
Q
A
T
S
N
L
D
S
I
T
E
-
N
H
I
K
D
A
I
Y
G
L
E
--
D
-----
D
V
T
V
I
I
I
A
H
R
L
S
T
I
V
N
C
D
K
I
Y
L
L
K
D
G
E
I
V
E
S
G
S
H
T
E
L
I
A
L
--
K
-
G
C
Y
---
F
K
M
W
K
Q
T
E
-
33
PsiBlast_CBE
63.63
35%
-94
- C1 -
4S0F
2
?
B:
[256-720]
-----------------------------------------------------------------------------------------------------------------------------
L
P
M
N
F
F
N
--
S
R
K
V
G
E
I
I
S
R
F
MD
A
S
K
I
--------
R
Q
A
---
I
S
G
----------
A
T
L
T
-
I
M
I
D
T
I
-
M
A
V
I
G
G
I
L
L
Y
I
----
Q
N
S
S
L
F
F
I
S
F
I
I
I
L
L
Y
-
G
I
I
V
T
VFNKPI
Q
N
A
N
R
QIMEDN
A
K
L
T
S
A
L
V
E
S
V
K
G
I
E
T
I
K
S
F
G
A
E
E
Q
T
E
K
S
T
R
---------
D
K
I
E
T
V
M
K
S
S
F
K
E
G
M
L
Y
I
N
L
S
S
L
-
T
G
--
I
V
A
G
L
G
G
I
V
I
L
W
A
G
A
Y
N
V
IKGNMSG
G
Q
-
L
L
A
F
N
A
L
L
A
Y
F
L
T
------
P
V
K
N
L
I
D
L
Q
P
L
I
Q
T
A
V
V
A
S
N
R
L
G
E
I
L
----
E
L
A
T
E
K
E
L
R
--
E
D
----
S
--
D
-
D
F
V
I
S
L
K
G
D
I
E
F
R
N
V
D
F
R
Y
--
G
L
R
--
K
-
P
---
V
L
K
N
I
N
L
T
I
P
K
G
K
T
V
A
I
V
G
E
S
G
S
G
K
T
T
L
A
K
L
L
M
N
F
Y
S
P
E
---
K
G
D
I
L
I
N
G
H
S
I
K
N
I
S
L
E
L
I
R
K
K
I
A
F
V
S
Q
D
V
F
I
F
S
G
T
V
K
E
N
L
C
L
-
G
--
N
E
-
N
---
V
-
D
M
D
E
I
I
K
A
A
K
M
A
N
A
H
D
F
I
E
K
L
P
L
K
Y
D
T
F
L
N
E
S
G
A
N
L
S
E
G
Q
K
Q
R
L
A
I
A
R
A
L
L
K
K
P
D
I
L
I
L
D
Q
A
T
S
N
L
D
S
I
T
E
-
N
H
I
K
D
A
I
Y
G
L
E
--
D
-----
D
V
T
V
I
I
I
A
H
R
L
S
T
I
V
N
C
D
K
I
Y
L
L
K
D
G
E
I
V
E
S
G
S
H
T
E
L
I
A
L
--
K
-
G
C
Y
---
F
K
M
W
K
Q
T
E
-
73
PsiBlast_CBE
59.11
44%
-124
- C1 -
1XEF
3
HLYBP_ECOLX
B:
[2-240]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
T
F
R
N
I
R
F
R
Y
--
K
P
D
--
S
-
P
V--
I
L
D
N
I
N
L
S
I
K
Q
G
E
V
I
G
I
V
G
R
S
G
S
G
K
S
T
L
T
K
L
I
Q
R
F
Y
I
P
E
---
N
G
Q
V
L
I
D
G
H
D
L
A
L
A
D
P
N
W
L
R
R
Q
V
G
V
V
L
Q
D
N
V
L
L
N
R
S
I
I
D
N
I
S
L
-
A
--
N
P
-
G
---
M
-
S
V
E
K
V
I
Y
A
A
K
L
A
G
A
H
D
F
I
S
E
L
R
E
G
Y
N
T
I
V
G
E
Q
G
A
G
L
S
G
G
Q
R
Q
R
I
A
I
A
R
A
L
V
N
N
P
K
I
L
I
F
D
E
A
T
S
A
L
D
Y
E
S
E
-
H
V
I
M
R
N
M
H
K
I
C
--
K
-----
G
R
T
V
I
I
I
A
A
R
L
S
T
V
K
N
A
D
R
I
I
V
M
E
K
G
K
I
V
E
Q
G
K
H
K
E
L
L
S
E
P-
E
-
S
L
Y
SYL
Y
Q
L
Q
S
D
---
74
PsiBlast_CBE
59.04
44%
-126
- C1 -
1XEF
3
HLYBP_ECOLX
A:
[2-240]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
T
F
R
N
I
R
F
R
Y
--
K
P
D
--
S
-
P
V--
I
L
D
N
I
N
L
S
I
K
Q
G
E
V
I
G
I
V
G
R
S
G
S
G
K
S
T
L
T
K
L
I
Q
R
F
Y
I
P
E
---
N
G
Q
V
L
I
D
G
H
D
L
A
L
A
D
P
N
W
L
R
R
Q
V
G
V
V
L
Q
D
N
V
L
L
N
R
S
I
I
D
N
I
S
L
-
A
--
N
P
-
G
---
M
-
S
V
E
K
V
I
Y
A
A
K
L
A
G
A
H
D
F
I
S
E
L
R
E
G
Y
N
T
I
V
G
E
Q
G
A
G
L
S
G
G
Q
R
Q
R
I
A
I
A
R
A
L
V
N
N
P
K
I
L
I
F
D
E
A
T
S
A
L
D
Y
E
S
E
-
H
V
I
M
R
N
M
H
K
I
C
--
K
-----
G
R
T
V
I
I
I
A
A
R
L
S
T
V
K
N
A
D
R
I
I
V
M
E
K
G
K
I
V
E
Q
G
K
H
K
E
L
L
S
E
P-
E
-
S
L
Y
S
Y
L
Y
Q
L
Q
S
D
---
72
PsiBlast_CBE
59.01
44%
-127
- C1 -
1XEF
3
HLYBP_ECOLX
C:
[2-240]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
T
F
R
N
I
R
F
R
Y
--
K
P
D
--
S
-
P
V--
I
L
D
N
I
N
L
S
I
K
Q
G
E
V
I
G
I
V
G
R
S
G
S
G
K
S
T
L
T
K
L
I
Q
R
F
Y
I
P
E
---
N
G
Q
V
L
I
D
G
H
D
L
A
L
A
D
P
N
W
L
R
R
Q
V
G
V
V
L
Q
D
N
V
L
L
N
R
S
I
I
D
N
I
S
L
-
A
--
N
P
-
G
---
M
-
S
V
E
K
V
I
Y
A
A
K
L
A
G
A
H
D
F
I
S
E
L
R
E
G
Y
N
T
I
V
G
E
Q
G
A
G
L
S
G
G
Q
R
Q
R
I
A
I
A
R
A
L
V
N
N
P
K
I
L
I
F
D
E
A
T
S
A
L
D
Y
E
S
E
-
H
V
I
M
R
N
M
H
K
I
C
--
K
-----
G
R
T
V
I
I
I
A
A
R
L
S
T
V
K
N
A
D
R
I
I
V
M
E
K
G
K
I
V
E
Q
G
K
H
K
E
L
L
S
E
P-
E
-
S
L
Y
SYL
Y
Q
L
Q
S
D
---
53
PsiBlast_CBE
58.89
44%
-127
- C1 -
2FF7
1
A:
[8-246]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
T
F
R
N
I
R
F
R
Y
--
K
P
D
--
S
-
P
V--
I
L
D
N
I
N
L
S
I
K
Q
G
E
V
I
G
I
V
G
R
S
G
S
G
K
S
T
L
T
K
L
I
Q
R
F
Y
I
P
E
---
N
G
Q
V
L
I
D
G
H
D
L
A
L
A
D
P
N
W
L
R
R
Q
V
G
V
V
L
Q
D
N
V
L
L
N
R
S
I
I
D
N
I
S
L
-
A
--
N
P
-
G
---
M
-
S
V
E
K
V
I
Y
A
A
K
L
A
G
A
H
D
F
I
S
E
L
R
E
G
Y
N
T
I
V
G
E
Q
G
A
G
L
S
G
G
Q
R
Q
R
I
A
I
A
R
A
L
V
N
N
P
K
I
L
I
F
D
E
A
T
S
A
L
D
Y
E
S
E
-
H
V
I
M
R
N
M
H
K
I
C
--
K
-----
G
R
T
V
I
I
I
A
H
R
L
S
T
V
K
N
A
D
R
I
I
V
M
E
K
G
K
I
V
E
Q
G
K
H
K
E
L
L
S
E
P-
E
-
S
L
Y
S
Y
L
Y
Q
L
Q
S
D
---
64
PsiBlast_CBE
58.42
42%
-113
- C1 -
3NH9
3
A:
[51-292]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
G
R
I
E
F
E
N
V
H
F
S
Y
--
A
D
G
--
R
-
E
---
T
L
Q
D
V
S
F
T
V
M
P
G
Q
T
L
A
L
V
G
P
S
G
A
G
K
S
T
I
L
R
L
L
F
R
F
Y
D
I
S
---
S
G
C
I
R
I
D
G
Q
D
I
S
Q
V
T
Q
A
S
L
R
S
H
I
G
V
V
P
Q
D
T
V
L
F
N
D
T
I
A
D
N
I
R
Y
-
G
--
R
V
-
T
---
A
-
G
N
D
E
V
E
A
A
A
Q
A
A
G
I
H
D
A
I
M
A
F
P
E
G
Y
R
T
Q
V
G
E
R
G
L
K
L
S
G
G
E
K
Q
R
V
A
I
A
R
T
I
L
K
A
P
G
I
I
L
L
D
E
A
T
S
A
L
D
T
S
N
E
-
R
A
I
Q
A
S
L
A
K
V
C
--
A
-----
N
R
T
T
I
V
V
A
H
R
L
S
T
V
V
N
A
D
Q
I
L
V
I
K
D
G
C
I
V
E
R
G
R
H
E
A
L
L
S
R
--
G
-
G
V
Y
A
D
M
W
Q
L
Q
Q
G
Q
--
70
PsiBlast_CBE
58.38
44%
-126
- C1 -
2FFA
2
A:
[8-246]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
T
F
R
N
I
R
F
R
Y
--
K
P
D
--
S
-
P
V--
I
L
D
N
I
N
L
S
I
K
Q
G
E
V
I
G
I
V
G
R
S
G
S
G
K
S
T
L
T
K
L
I
Q
R
F
Y
I
P
E
---
N
G
Q
V
L
I
D
G
H
D
L
A
L
A
D
P
N
W
L
R
R
Q
V
G
V
V
L
Q
D
N
V
L
L
N
R
S
I
I
D
N
I
S
L
-
A
--
N
P
-
G
---
M
-
S
V
E
K
V
I
Y
A
A
K
L
A
G
A
H
D
F
I
S
E
L
R
E
G
Y
N
T
I
V
G
E
Q
G
A
G
L
S
G
G
Q
R
Q
R
I
A
I
A
R
A
L
V
N
N
P
K
I
L
I
F
D
E
A
T
S
A
L
D
Y
E
S
E
-
H
V
I
M
R
N
M
H
K
I
C
--
K
-----
G
R
T
V
I
I
I
A
A
R
L
S
T
V
K
N
A
D
R
I
I
V
M
E
K
G
K
I
V
E
Q
G
K
H
K
E
L
L
S
E
P-
E
-
S
L
Y
S
Y
L
Y
Q
L
Q
S
D
---
71
PsiBlast_CBE
58.31
44%
-124
- C1 -
1XEF
3
D:
[2-240]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
T
F
R
N
I
R
F
R
Y
--
K
P
D
--
S
-
P
V--
I
L
D
N
I
N
L
S
I
K
Q
G
E
V
I
G
I
V
G
R
S
G
S
G
K
S
T
L
T
K
L
I
Q
R
F
Y
I
P
E
---
N
G
Q
V
L
I
D
G
H
D
L
A
L
A
D
P
N
W
L
R
R
Q
V
G
V
V
L
Q
D
N
V
L
L
N
R
S
I
I
D
N
I
S
L
-
A
--
N
P
-
G
---
M
-
S
V
E
K
V
I
Y
A
A
K
L
A
G
A
H
D
F
I
S
E
L
R
E
G
Y
N
T
I
V
G
E
Q
G
A
G
L
S
G
G
Q
R
Q
R
I
A
I
A
R
A
L
V
N
N
P
K
I
L
I
F
D
E
A
T
S
A
L
D
Y
E
S
E
-
H
V
I
M
R
N
M
H
K
I
C
--
K
-----
G
R
T
V
I
I
I
A
A
R
L
S
T
V
K
N
A
D
R
I
I
V
M
E
K
G
K
I
V
E
Q
G
K
H
K
E
L
L
S
E
P-
E
-
S
L
Y
SYL
Y
Q
L
Q
S
D
---
66
PsiBlast_CBE
58.18
44%
-128
- C1 -
2FGJ
2
D:
[8-246]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
T
F
R
N
I
R
F
R
Y
--
K
P
D
--
S
-
P
V--
I
L
D
N
I
N
L
S
I
K
Q
G
E
V
I
G
I
V
G
R
S
G
S
G
K
S
T
L
T
K
L
I
Q
R
F
Y
I
P
E
---
N
G
Q
V
L
I
D
G
H
D
L
A
L
A
D
P
N
W
L
R
R
Q
V
G
V
V
L
Q
D
N
V
L
L
N
R
S
I
I
D
N
I
S
L
-
A
--
N
P
-
G
---
M
-
S
V
E
K
V
I
Y
A
A
K
L
A
G
A
H
D
F
I
S
E
L
R
E
G
Y
N
T
I
V
G
E
Q
G
A
G
L
S
G
G
Q
R
Q
R
I
A
I
A
R
A
L
V
N
N
P
K
I
L
I
F
D
E
A
T
S
A
L
D
Y
E
S
E
-
H
V
I
M
R
N
M
H
K
I
C
--
K
-----
G
R
T
V
I
I
I
A
A
R
L
S
T
V
K
N
A
D
R
I
I
V
M
E
K
G
K
I
V
E
Q
G
K
H
K
E
L
L
S
E
P-
E
-
S
L
Y
SYL
Y
Q
L
Q
S
D
---
55
PsiBlast_CBE
57.77
44%
-127
- C1 -
2PMK
1
A:
[4-242]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
T
F
R
N
I
R
F
R
Y
--
K
P
D
--
S
-
P
V--
I
L
D
N
I
N
L
S
I
K
Q
G
E
V
I
G
I
V
G
R
S
G
S
G
K
S
T
L
T
K
L
I
Q
R
F
Y
I
P
E
---
N
G
Q
V
L
I
D
G
H
D
L
A
L
A
D
P
N
W
L
R
R
Q
V
G
V
V
L
Q
D
N
V
L
L
N
R
S
I
I
D
N
I
S
L
-
A
--
N
P
-
G
---
M
-
S
V
E
K
V
I
Y
A
A
K
L
A
G
A
H
D
F
I
S
E
L
R
E
G
Y
N
T
I
V
G
E
Q
G
A
G
L
S
G
G
Q
R
Q
R
I
A
I
A
R
A
L
V
N
N
P
K
I
L
I
F
D
E
A
T
S
A
L
D
Y
E
S
E
-
H
V
I
M
R
N
M
H
K
I
C
--
K
-----
G
R
T
V
I
I
I
A
H
R
L
S
T
V
K
N
A
D
R
I
I
V
M
E
K
G
K
I
V
E
Q
G
K
H
K
E
L
L
S
E
P-
E
-
S
L
Y
S
Y
L
Y
Q
L
Q
S
D
---
57
PsiBlast_CBE
57.71
44%
-127
- C1 -
2FGK
2
D:
[8-246]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
T
F
R
N
I
R
F
R
Y
--
K
P
D
--
S
-
P
V--
I
L
D
N
I
N
L
S
I
K
Q
G
E
V
I
G
I
V
G
R
S
G
S
G
K
S
T
L
T
K
L
I
Q
R
F
Y
I
P
E
---
N
G
Q
V
L
I
D
G
H
D
L
A
L
A
D
P
N
W
L
R
R
Q
V
G
V
V
L
Q
D
N
V
L
L
N
R
S
I
I
D
N
I
S
L
-
A
--
N
P
-
G
---
M
-
S
V
E
K
V
I
Y
A
A
K
L
A
G
A
H
D
F
I
S
E
L
R
E
G
Y
N
T
I
V
G
E
Q
G
A
G
L
S
G
G
Q
R
Q
R
I
A
I
A
R
A
L
V
N
N
P
K
I
L
I
F
D
Q
A
T
S
A
L
D
Y
E
S
E
-
H
V
I
M
R
N
M
H
K
I
C
--
K
-----
G
R
T
V
I
I
I
A
H
R
L
S
T
V
K
N
A
D
R
I
I
V
M
E
K
G
K
I
V
E
Q
G
K
H
K
E
L
L
S
E
P-
E
-
S
L
Y
SYL
Y
Q
L
Q
S
D
---
59
PsiBlast_CBE
57.67
44%
-129
- C1 -
2FGK
2
HLYBP_ECOLX
B:
[8-246]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
T
F
R
N
I
R
F
R
Y
--
K
P
D
--
S
-
P
V--
I
L
D
N
I
N
L
S
I
K
Q
G
E
V
I
G
I
V
G
R
S
G
S
G
K
S
T
L
T
K
L
I
Q
R
F
Y
I
P
E
---
N
G
Q
V
L
I
D
G
H
D
L
A
L
A
D
P
N
W
L
R
R
Q
V
G
V
V
L
Q
D
N
V
L
L
N
R
S
I
I
D
N
I
S
L
-
A
--
N
P
-
G
---
M
-
S
V
E
K
V
I
Y
A
A
K
L
A
G
A
H
D
F
I
S
E
L
R
E
G
Y
N
T
I
V
G
E
Q
G
A
G
L
S
G
G
Q
R
Q
R
I
A
I
A
R
A
L
V
N
N
P
K
I
L
I
F
D
Q
A
T
S
A
L
D
Y
E
S
E
-
H
V
I
M
R
N
M
H
K
I
C
--
K
-----
G
R
T
V
I
I
I
A
H
R
L
S
T
V
K
N
A
D
R
I
I
V
M
E
K
G
K
I
V
E
Q
G
K
H
K
E
L
L
S
E
P-
E
-
S
L
Y
SYL
Y
Q
L
Q
S
D
---
62
PsiBlast_CBE
57.39
42%
-115
- C1 -
3NHB
3
A:
[51-292]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
G
R
I
E
F
E
N
V
H
F
S
Y
--
A
D
---
R
-
E
---
T
L
Q
D
V
S
F
T
V
M
P
G
Q
T
L
A
L
V
G
P
S
G
A
G
K
S
T
I
L
R
L
L
F
R
F
Y
D
I
S
---
S
G
C
I
R
I
D
G
Q
D
I
S
Q
V
T
Q
A
S
L
R
S
H
I
G
V
V
P
Q
D
T
V
L
F
N
D
T
I
A
D
N
I
R
Y
-
G
--
R
V
-
T
---
A
-
G
N
D
E
V
E
A
A
A
Q
A
A
G
I
H
D
A
I
M
A
F
P
E
G
Y
R
T
Q
V
G
E
R
G
L
K
L
S
G
G
E
K
Q
R
V
A
I
A
R
T
I
L
K
A
P
G
I
I
L
L
D
E
A
T
S
A
L
D
T
S
N
E
-
R
A
I
Q
A
S
L
A
K
V
C
--
A
-----
N
R
T
T
I
V
V
A
H
R
L
S
T
V
V
N
A
D
Q
I
L
V
I
K
D
G
C
I
V
E
R
G
R
H
E
A
L
L
S
R
--
G
-
G
V
Y
A
D
M
W
Q
L
Q
Q
G
Q
--
61
PsiBlast_CBE
57.31
44%
-124
- C1 -
2FFB
1
A:
[8-246]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
T
F
R
N
I
R
F
R
Y
--
K
P
D
--
S
-
P
V--
I
L
D
N
I
N
L
S
I
K
Q
G
E
V
I
G
I
V
G
R
S
G
S
G
K
S
T
L
T
K
L
I
Q
R
F
Y
I
P
E
---
N
G
Q
V
L
I
D
G
H
D
L
A
L
A
D
P
N
W
L
R
R
Q
V
G
V
V
L
Q
D
N
V
L
L
N
R
S
I
I
D
N
I
S
L
-
A
--
N
P
-
G
---
M
-
S
V
E
K
V
I
Y
A
A
K
L
A
G
A
H
D
F
I
S
E
L
R
E
G
Y
N
T
I
V
G
E
Q
G
A
G
L
S
G
G
Q
R
Q
R
I
A
I
A
R
A
L
V
N
N
P
K
I
L
I
F
D
Q
A
T
S
A
L
D
Y
E
S
E
-
H
V
I
M
R
N
M
H
K
I
C
--
K
-----
G
R
T
V
I
I
I
A
H
R
L
S
T
V
K
N
A
D
R
I
I
V
M
E
K
G
K
I
V
E
Q
G
K
H
K
E
L
L
S
E
P-
E
-
S
L
Y
S
Y
L
Y
Q
L
Q
S
D
---
67
PsiBlast_CBE
57.14
44%
-122
- C1 -
2FGJ
2
HLYBP_ECOLX
C:
[8-246]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
T
F
R
N
I
R
F
R
Y
--
K
P
D
--
S
-
P
V--
I
L
D
N
I
N
L
S
I
K
Q
G
E
V
I
G
I
V
G
R
S
G
S
G
K
S
T
L
T
K
L
I
Q
R
F
Y
I
P
E
---
N
G
Q
V
L
I
D
G
H
D
L
A
L
A
D
P
N
W
L
R
R
Q
V
G
V
V
L
Q
D
N
V
L
L
N
R
S
I
I
D
N
I
S
L
-
A
--
N
P
-
G
---
M
-
S
V
E
K
V
I
Y
A
A
K
L
A
G
A
H
D
F
I
S
E
L
R
E
G
Y
N
T
I
V
G
E
Q
G
A
G
L
S
G
G
Q
R
Q
R
I
A
I
A
R
A
L
V
N
N
P
K
I
L
I
F
D
E
A
T
S
A
L
D
Y
E
S
E
-
H
V
I
M
R
N
M
H
K
I
C
--
K
-----
G
R
T
V
I
I
I
A
A
R
L
S
T
V
K
N
A
D
R
I
I
V
M
E
K
G
K
I
V
E
Q
G
K
H
K
E
L
L
S
E
P-
E
-
S
L
Y
SYL
Y
Q
L
Q
S
D
---
56
PsiBlast_CBE
57.12
44%
-128
- C1 -
3B5J
1
A:
[4-242]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
T
F
R
N
I
R
F
R
Y
--
K
P
D
--
S
-
P
V--
I
L
D
N
I
N
L
S
I
K
Q
G
E
V
I
G
I
V
G
R
A
G
S
G
K
S
T
L
T
K
L
I
Q
R
F
Y
I
P
E
---
N
G
Q
V
L
I
D
G
H
D
L
A
L
A
D
P
N
W
L
R
R
Q
V
G
V
V
L
Q
D
N
V
L
L
N
R
S
I
I
D
N
I
S
L
-
A
--
N
P
-
G
---
M
-
S
V
E
K
V
I
Y
A
A
K
L
A
G
A
H
D
F
I
S
E
L
R
E
G
Y
N
T
I
V
G
E
Q
G
A
G
L
S
G
G
Q
R
Q
R
I
A
I
A
R
A
L
V
N
N
P
K
I
L
I
F
D
E
A
T
S
A
L
D
Y
E
S
E
-
H
V
I
M
R
N
M
H
K
I
C
--
K
-----
G
R
T
V
I
I
I
A
H
R
L
S
T
V
K
N
A
D
R
I
I
V
M
E
K
G
K
I
V
E
Q
G
K
H
K
E
L
L
S
E
P-
E
-
S
L
Y
S
Y
L
Y
Q
L
Q
S
D
---
69
PsiBlast_CBE
56.95
44%
-121
- C1 -
2FGJ
2
HLYBP_ECOLX
A:
[8-246]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
T
F
R
N
I
R
F
R
Y
--
K
P
D
--
S
-
P
V--
I
L
D
N
I
N
L
S
I
K
Q
G
E
V
I
G
I
V
G
R
S
G
S
G
K
S
T
L
T
K
L
I
Q
R
F
Y
I
P
E
---
N
G
Q
V
L
I
D
G
H
D
L
A
L
A
D
P
N
W
L
R
R
Q
V
G
V
V
L
Q
D
N
V
L
L
N
R
S
I
I
D
N
I
S
L
-
A
--
N
P
-
G
---
M
-
S
V
E
K
V
I
Y
A
A
K
L
A
G
A
H
D
F
I
S
E
L
R
E
G
Y
N
T
I
V
G
E
Q
G
A
G
L
S
G
G
Q
R
Q
R
I
A
I
A
R
A
L
V
N
N
P
K
I
L
I
F
D
E
A
T
S
A
L
D
Y
E
S
E
-
H
V
I
M
R
N
M
H
K
I
C
--
K
-----
G
R
T
V
I
I
I
A
A
R
L
S
T
V
K
N
A
D
R
I
I
V
M
E
K
G
K
I
V
E
Q
G
K
H
K
E
L
L
S
E
P-
E
-
S
L
Y
S
Y
L
Y
Q
L
Q
S
D
---
58
PsiBlast_CBE
56.92
44%
-125
- C1 -
2FGK
2
HLYBP_ECOLX
C:
[8-246]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
T
F
R
N
I
R
F
R
Y
--
K
P
D
--
S
-
P
V--
I
L
D
N
I
N
L
S
I
K
Q
G
E
V
I
G
I
V
G
R
S
G
S
G
K
S
T
L
T
K
L
I
Q
R
F
Y
I
P
E
---
N
G
Q
V
L
I
D
G
H
D
L
A
L
A
D
P
N
W
L
R
R
Q
V
G
V
V
L
Q
D
N
V
L
L
N
R
S
I
I
D
N
I
S
L
-
A
--
N
P
-
G
---
M
-
S
V
E
K
V
I
Y
A
A
K
L
A
G
A
H
D
F
I
S
E
L
R
E
G
Y
N
T
I
V
G
E
Q
G
A
G
L
S
G
G
Q
R
Q
R
I
A
I
A
R
A
L
V
N
N
P
K
I
L
I
F
D
Q
A
T
S
A
L
D
Y
E
S
E
-
H
V
I
M
R
N
M
H
K
I
C
--
K
-----
G
R
T
V
I
I
I
A
H
R
L
S
T
V
K
N
A
D
R
I
I
V
M
E
K
G
K
I
V
E
Q
G
K
H
K
E
L
L
S
E
P-
E
-
S
L
Y
SYL
Y
Q
L
Q
S
D
---
124
HHSearch
56.90
43%
-120
- C1 -
2FF7
1
A:
[5-243]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
H
H
D
I
T
F
R
N
I
R
F
R
Y
--
K
P
D
S-
P
-
V
---
I
L
D
N
I
N
L
S
I
K
Q
G
E
V
I
G
I
V
G
R
S
G
S
G
K
S
T
L
T
K
L
I
Q
R
F
Y
I
P
E
---
N
G
Q
V
L
I
D
G
H
D
L
A
L
A
D
P
N
W
L
R
R
Q
V
G
V
V
L
Q
D
N
V
L
L
N
R
S
I
I
D
N
I
S
L
-
A
--
N
P
-
G
---
M
-
S
V
E
K
V
I
Y
A
A
K
L
A
G
A
H
D
F
I
S
E
L
R
E
G
Y
N
T
I
V
G
E
Q
G
A
G
L
S
G
G
Q
R
Q
R
I
A
I
A
R
A
L
V
N
N
P
K
I
L
I
F
D
E
A
T
S
A
L
D
Y
E
S
E
-
H
V
I
M
R
N
M
H
K
I
C
--
K
-----
G
R
T
V
I
I
I
A
H
R
L
S
T
V
K
N
A
D
R
I
I
V
M
E
K
G
K
I
V
E
Q
G
K
H
K
E
L
L
S
E
--
P
E
S
L
Y
---
S
Y
L
Y
Q
L
Q
S
-
60
PsiBlast_CBE
56.89
44%
-126
- C1 -
2FGK
2
HLYBP_ECOLX
A:
[8-246]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
T
F
R
N
I
R
F
R
Y
--
K
P
D
--
S
-
P
V--
I
L
D
N
I
N
L
S
I
K
Q
G
E
V
I
G
I
V
G
R
S
G
S
G
K
S
T
L
T
K
L
I
Q
R
F
Y
I
P
E
---
N
G
Q
V
L
I
D
G
H
D
L
A
L
A
D
P
N
W
L
R
R
Q
V
G
V
V
L
Q
D
N
V
L
L
N
R
S
I
I
D
N
I
S
L
-
A
--
N
P
-
G
---
M
-
S
V
E
K
V
I
Y
A
A
K
L
A
G
A
H
D
F
I
S
E
L
R
E
G
Y
N
T
I
V
G
E
Q
G
A
G
L
S
G
G
Q
R
Q
R
I
A
I
A
R
A
L
V
N
N
P
K
I
L
I
F
D
Q
A
T
S
A
L
D
Y
E
S
E
-
H
V
I
M
R
N
M
H
K
I
C
--
K
-----
G
R
T
V
I
I
I
A
H
R
L
S
T
V
K
N
A
D
R
I
I
V
M
E
K
G
K
I
V
E
Q
G
K
H
K
E
L
L
S
E
P-
E
-
S
L
Y
S
Y
L
Y
Q
L
Q
S
D
---
68
PsiBlast_CBE
56.87
44%
-123
- C1 -
2FGJ
2
HLYBP_ECOLX
B:
[8-246]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
T
F
R
N
I
R
F
R
Y
--
K
P
D
--
S
-
P
V--
I
L
D
N
I
N
L
S
I
K
Q
G
E
V
I
G
I
V
G
R
S
G
S
G
K
S
T
L
T
K
L
I
Q
R
F
Y
I
P
E
---
N
G
Q
V
L
I
D
G
H
D
L
A
L
A
D
P
N
W
L
R
R
Q
V
G
V
V
L
Q
D
N
V
L
L
N
R
S
I
I
D
N
I
S
L
-
A
--
N
P
-
G
---
M
-
S
V
E
K
V
I
Y
A
A
K
L
A
G
A
H
D
F
I
S
E
L
R
E
G
Y
N
T
I
V
G
E
Q
G
A
G
L
S
G
G
Q
R
Q
R
I
A
I
A
R
A
L
V
N
N
P
K
I
L
I
F
D
E
A
T
S
A
L
D
Y
E
S
E
-
H
V
I
M
R
N
M
H
K
I
C
--
K
-----
G
R
T
V
I
I
I
A
A
R
L
S
T
V
K
N
A
D
R
I
I
V
M
E
K
G
K
I
V
E
Q
G
K
H
K
E
L
L
S
E
P-
E
-
S
L
Y
SYL
Y
Q
L
Q
S
D
---
63
PsiBlast_CBE
56.47
42%
-113
- C1 -
3NHA
4
A:
[51-292]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
G
R
I
E
F
E
N
V
H
F
S
Y
--
A
D
---
R
-
E
---
T
L
Q
D
V
S
F
T
V
M
P
G
Q
T
L
A
L
V
G
P
S
G
A
G
K
S
T
I
L
R
L
L
F
R
F
Y
D
I
S
---
S
G
C
I
R
I
D
G
Q
D
I
S
Q
V
T
Q
A
S
L
R
S
H
I
G
V
V
P
Q
D
T
V
L
F
N
D
T
I
A
D
N
I
R
Y
-
G
--
R
V
-
T
---
A
-
G
N
D
E
V
E
A
A
A
Q
A
A
G
I
H
D
A
I
M
A
F
P
E
G
Y
R
T
Q
V
G
E
R
G
L
K
L
S
G
G
E
K
Q
R
V
A
I
A
R
T
I
L
K
A
P
G
I
I
L
L
D
E
A
T
S
A
L
D
T
S
N
E
-
R
A
I
Q
A
S
L
A
K
V
C
--
A
-----
N
R
T
T
I
V
V
A
H
R
L
S
T
V
V
N
A
D
Q
I
L
V
I
K
D
G
C
I
V
E
R
G
R
H
E
A
L
L
S
R
--
G
-
G
V
Y
A
D
M
W
Q
L
Q
Q
G
Q
--
84
PsiBlast_CBE
54.06
37%
-114
- C1 -
1JJ7
2
A:
[11-254]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
E
G
L
V
Q
F
Q
D
V
S
F
A
Y
---
P
N
--
R
-
P
DVL
V
L
Q
G
L
T
F
T
L
R
P
G
E
V
T
A
L
V
G
P
N
G
S
G
K
S
T
V
A
A
L
L
Q
N
L
Y
Q
P
T
---
G
G
Q
L
L
L
D
G
K
P
L
P
Q
Y
E
H
R
Y
L
H
R
Q
V
A
A
V
G
Q
E
P
Q
V
F
G
R
S
L
Q
E
N
I
A
Y
-
G
L-
T
Q
-
K
---
P
-
T
M
E
E
I
T
A
A
A
V
K
S
G
A
H
S
F
I
S
G
L
P
Q
G
Y
D
T
E
V
D
E
A
G
S
Q
L
S
G
G
Q
R
Q
A
V
A
L
A
R
A
L
I
R
K
P
C
V
L
I
L
D
D
A
T
S
A
L
D
A
N
S
Q
-
L
Q
V
E
---
Q
L
L
Y
--
E
SPERY
S
R
S
V
L
L
I
T
Q
H
L
S
L
V
E
Q
A
D
H
I
L
F
L
E
G
G
A
I
R
E
G
G
T
H
Q
Q
L
M
E
K
--
K
-
G
C
Y
---
W
A
M
V
Q
A
---
120
HHSearch
51.51
35%
-105
- C1 -
3VX4
3
?
A:
[29-267]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
-
F
L
D
G
D
I
S
F
E
N
L
S
Y
K
Y
--
G
F
G
--
R
-
D
---
T
L
S
D
I
N
L
S
I
K
K
G
S
K
V
S
L
V
G
A
S
G
S
G
K
T
T
L
A
K
L
I
V
N
F
Y
E
P
N
---
K
G
I
V
R
I
N
G
N
D
L
K
V
I
D
K
T
A
L
R
R
H
I
S
Y
L
P
Q
Q
A
Y
V
F
S
G
S
I
M
D
N
L
V
L
-
G
--
A
K
-
E
G--
T
-
S
Q
E
D
I
I
R
A
C
E
I
A
E
I
R
S
D
I
E
Q
M
P
Q
G
Y
Q
T
E
L
S
D
-
G
A
G
I
S
G
G
Q
K
Q
R
I
A
L
A
R
A
L
L
T
Q
A
P
V
L
I
L
D
A
A
T
S
S
L
D
I
L
T
E
-
K
K
I
I
S
N
L
L
Q
M
---
T
-----
E
K
T
I
I
F
V
A
H
R
L
S
I
S
Q
R
T
D
E
V
I
V
M
D
Q
G
K
I
V
E
Q
G
T
H
K
E
L
L
A
K
--
Q
-
G
F
Y
---
Y
N
L
F
N
----
86
PsiBlast_CBE
51.50
38%
-107
- C1 -
3VX4
3
?
A:
[29-267]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
-
F
L
D
G
D
I
S
F
E
N
L
S
Y
K
Y
--
G
F
G
--
R
-
D
---
T
L
S
D
I
N
L
S
I
K
K
G
S
K
V
S
L
V
G
A
S
G
S
G
K
T
T
L
A
K
L
I
V
N
F
Y
E
P
N
---
K
G
I
V
R
I
N
G
N
D
L
K
V
I
D
K
T
A
L
R
R
H
I
S
Y
L
P
Q
Q
A
Y
V
F
S
G
S
I
M
D
N
L
V
L
G
A
--
K
E
-
G
---
T
-
S
Q
E
D
I
I
R
A
C
E
I
A
E
I
R
S
D
I
E
Q
M
P
Q
G
Y
Q
T
E
L
S
D
-
G
A
G
I
S
G
G
Q
K
Q
R
I
A
L
A
R
A
L
L
T
Q
A
P
V
L
I
L
D
A
A
T
S
S
L
D
I
L
T
E
K
K
I
I
S
N
L
L
Q
M
T
E
--
K
-------
T
I
I
F
V
A
H
R
L
S
I
S
Q
R
T
D
E
V
I
V
M
D
Q
G
K
I
V
E
Q
G
T
H
K
E
L
L
A
K
--
Q
-
G
F
Y
---
Y
N
L
F
N
----
122
HHSearch
48.16
38%
-112
- C1 -
1MV5
3
LMRA_LACLA
A:
[2-237]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
S
A
R
H
V
D
F
A
Y
--
D
D
S
--
E
-
Q
---
I
L
R
D
I
S
F
E
A
Q
P
N
S
I
I
A
F
A
G
P
S
G
G
G
K
S
T
I
F
S
L
L
E
R
F
Y
Q
P
T
---
A
G
E
I
T
I
D
G
Q
P
I
D
N
I
S
L
E
N
W
R
S
Q
I
G
F
V
S
Q
D
S
A
I
M
A
G
T
I
R
E
N
L
T
Y
-
G
--
L
E
-
G
D--
Y
-
T
D
E
D
L
W
Q
V
L
D
L
A
F
A
R
S
F
V
E
N
M
P
D
Q
L
N
T
E
V
G
E
R
G
V
K
I
S
G
G
Q
R
Q
R
L
A
I
A
R
A
F
L
R
N
P
K
I
L
M
L
D
E
A
T
A
S
L
D
S
E
S
E
-
S
M
V
Q
K
A
L
D
S
L
M
--
K
-----
G
R
T
T
L
V
I
A
H
R
L
S
T
I
V
D
A
D
K
I
Y
F
I
E
K
G
Q
I
T
G
S
G
K
H
N
E
L
V
A
T
--
H
-
P
L
Y
---
A
K
Y
V
S
E
Q
L
-