@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : gbs1288: (2015-12-06 )
MKRKDLFGDKQTQYTIRKLSVGVASVATGVCIFLHSPQVFAEEVSVSPATTAIAKSNINQVDNRQSTNLKDDINSNSETVVTPSDMPDTKQLVSDETDTQKGVTEPDKATSLLEENKGPVSDKNTLDLKVAPSTLQNTPDKTSQAIGAPSPTLKVANQAPQIENGYFRLHLKELPQGHPVESTGLWIWGDVDQPSSNWPNGAIPMTNAKKDDYGYYVDFKLSEKQRKQISFLINNKAGTNLSGDHHIPLLRPEMNQVWIDEKYGIHTYQPLKEGYVRINYLSSSGNYDHLSAWLFKDVATPSTTWPDGSNFVNQGLYGRYIDVPLKTNAKEIGFLILDESKTGDAVKVQPNDYVFRDLANHNQIFVKDKDPKVYNNPYYIDQVQLKDAQQTDLTSIQASFTTLDGVDKTEILKELKVTDKNQNAIQISDITLDTSKSLLIIKGDFNPKQGHFNISYNGNNVTTRQSWEFKDQLYAYSGNLGAVLNQDGSKVEASLWSPSADSVTMIIYDKDNQNRVVATTPLVKNNKGVWQTILDTKLGIKNYTGYYYLYEIKRGKDKVKILDPYAKSLAEWDSNTVNDDIKTAKAAFVNPSQLGPQNLSFAKIANFKGRQDAVIYEAHVRDFTSDQSLDGKLKNQFVTFAAFSEKLDYLQKLGVTHIQLLPVLSYFYVNEMDKSRSTAYTSSDNNYNWGYDPQSYFALSGMYSEKPKDPSARIAELKQLIHDIHKRGMGVILDVVYNHTAKTYLFEDIEPNYYHFMNEDGSPRESFGGGRLGTTHAMSRRVLVDSIKYLTSEFKVDGFRFDMMGDHDAAAIELAYKEAKAINPNMIMIGEGWRTFQGDQGKPVKPADQDWMKSTDTVGVFSDDIRNSLKSGFPNEGTPAFITGGPQSLQGIFKNIKAQPGNFEADSPGDVVQYIAAHDNLTLHDVIAKSINKDPKVAEEEIHRRLRLGNVMILTSQGTAFIHSGQEYGRTKRLLNPDYMTKVSDDKLPNKATLIEAVKEYPYFIHDSYDSSDAINHFDWAAATDNNKHPISTKTQAYTAGLITLRRSTDAFRKLSKAEIDREVSLITEVGQGDIKEKDLVIAYQTIDSKGDIYAVFVNADSKARNVLLGEKYKHLLKGQVIVDADQAGIKPISTPRGVHFEKDSLLIDPLTAIVIKVGKVAPSPKEELQADYPKTQSFKGSKTVEKVNRIANKTSITPVVSNKTDSYLTNEANLPKTGDKSSKILSVVGISILASLLALLGLSLKRNRHLK
Atome Classification :
(20 SA)
.........10........20........30........40........50........60........70........80........90........100.......110.......120.......130.......140.......150.......160.......170.......180.......190---.........200.......210.......220.......230.......240.......250.......260.......270.......280------........290....-...300---........-.310.......320.......330.......340.......350.....-..360.......370..-.....380---........390.....--..400.......410---.......-.420--........430...----------....440.....---..450....-...----.460.......470---.......---.-.---480....-...490.......500.......510.......520....-....530....--.--.-.540.....-...550.------...---------------------------.---------..560.......570...--..----------------.----------------.580.......590--.......600.-.--...----..610..---.....620..-.-...-.630.....--------..640-------.-----------.-------.----..-----------...650.......660.......670-..-..----------------------------------------------------.-----------------------------------..680...-----------------....690.......700......-----------------------------------------------------.710.......-720...-..-..730..-......740.------.--.------.------..------..------------.-750.....-..760.-......-.770.......-.780.......790.......800..-....----.810---...-------------------------------......820-........830.......840.......850---.....---..860...----....870...-.-----------------------.-----..880....--------------------...890---------..----.---------------.-------------------------..----.------------------------..---------------900----.--.------.-----....910.......920...---....930.....-------------------------.--------------------------.940.......--..-950....----...960.......970......-----.980.......990.....----..----1000.....-.1010-----......1020...------------..---------------.1030......1040.......1050......1060-----.....-...1070---....-.-..1080.-------.....------------1090------.----........1100..-..---..1110......1120-.....-.1130.-....---.1140.......1150......1160......1170......1180......1190..-....1200......1210......1220......1230......1240......1250
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MKRKDLFGDKQ
T
Q
Y
T
I
R
KLSV
G
V
A
S
VA
T
G
V
C
I
F
LH
S
P
Q
V
F
A
E
E
VSVSPA
T
T
A
I
A
KSN
I
N
Q
VDNRQSTNLKDDINSNS
E
T
V
V
TPSDMP
D
T
K
Q
L
VSDETDTQKGVTE
P
D
K
A
T
S
L
L
E
ENKGPVSDK
N
T
L
D
L
K
VAP
S
T
LQNTPDKTSQAIGAPSPTLKVANQAPQIEN
G
Y
F
R
L
H
L
K
ELPQGHPVEST
G
L
W
I
W
GD-----VDQPSSNWPNGAIPMTNAKKDDY
G
Y
Y
V
D
F
KL
S
E
K
Q
R
K
Q
I
S
F
L
I
NNKAGTNLSGDHHIPLLRPE
M
N
Q
V
W
IDEKYGIHT
Y
Q
P
LKEG
Y
V
R
I
N
Y
L
-------SSSGN
Y
D
H
L
S
A
W
L
F
K
-DVAT-----PSTTWPDG-
S
N
F
V
NQGLYG
R
Y
IDVPLKTNA
K
E
I
G
F
L
I
L
DESKTG
D
A
V
K
VQPN
D
Y
V
F
R
D
-LANH
N
Q
I
F
V
KDKDPKVY-NN
P
Y
Y
I
D
----
Q
V
Q
LKDAQQT
D
L
T
S
I
Q
--
A
S
FTTLDGV
D
K
T
E
I
----
L
K
E
L
KVT-DKN---Q
N
A
I
Q
I
S
D
I
T
LDTS----------K
S
L
L
I
I
KGDFNP---KQ
G
H
-
F
N
I
S
-YNG----NN
V
T
TRQSWEFK-----D
Q
L
Y
A
YS---G-N---L
G
A
V
LNQ-DG
S
K
V
E
A
S
LWSPSAD
S
V
T
M
I
I
Y
DKDNQ
N
R
V
V
A
TTP-LVKN-NK
G
V
W
Q
T
I
L
D
T--K--L-GIK-NYT
G
Y
-
Y
Y
L
Y
E
IK------RGK---------------------------D---------
K
V
K
I
L
D
P
Y
A
K
S
L
A
EWDSN--TV----------------N----------------DDIK
T
A
K
AAFV
N
P
S
--QLGPQNL
S
F
A
K
-I--ANF----KGRQ
D
A
V
---
I
Y
E
A
HVRDFT-S-DQS-L
D
G
K
L
KN
Q
F
--------
V
T
F
A
--------
A
-----------
F
-------
S
----
E
K
-----------
L
D
Y
L
Q
K
LGV
T
H
I
Q
L
L
P
V
L
S
Y
F
Y
V
N
E
M-DK-SR----------------------------------------------------S-----------------------------------TAYTSSDN-----------------NYNWGYDP
Q
S
Y
F
A
LSGMYSEKPK-----------------------------------------------------DP
S
A
R
I
A
E
L
K
Q
-
L
I
H
D
I
H
-KR-
G
M
G
-
V
I
L
-
D
V
V
YNHT--A------
K
--
T
------
Y
------
L
F------ED------------I-EP
N
Y
Y
H
F
M-NED-GS-PRESFG-GGR-LG
T
T
H
A
M
-
S
R
R
V
L
V
D
S
I
K
Y
L
T
S
EFKVD
G
F
R
F
DMM-GDHD----
A
A
-----
A
I
E
-------------------------------
L
A
Y
KEAKA--INP
N
M
I
M
IGEGWRTFQGDQGKPVKPA
D
Q
D
W
M
---KSTDT---VGV
F
S
D
D
I
----
R
N
S
L
KSGFPN-E-----------------------G-----T
P
A
F
ITG
G
P
--------------------
Q
S
L
Q
-----------
G
I
----
F
---------------
K
-------------------------
N
I----K------------------------AQ---------------PGN----F--E------A-----DSP
G
D
V
V
Q
Y
I
A
AHDN
L
T
L
H
D
---
V
I
A
K
S
INKDPK
V
-------------------------
A
--------------------------
E
E
--
E
I
H
R
R
LR--LG-
N
V
M
I
L
TS----QG
T
A
F
I
HS
G
Q
EYGRTKRLL
N
P
D
-----
Y
M
TKVSDDKLP
N
K
A
T
L
I
E
A
----
V
K
----EYP
Y
F
I
HDS-YDSSD-----AINHFDWAAATDN------------NK---------------HPISTKT
Q
A
Y
T
A
G
-
L
I
T
L
RRS
T
D
A
F
R
K
L
S
K
A
E
I
D
-------
R
E
V
S
L
-
I
T
EVGQ----GDIK-E-K
D
L
V
I
A
Y
-------
Q
T
IDS------------K---------G----
D
I
Y
A
V
F
VNADSKAR-NV---
L
L
G
E
K
Y
K
H
L
LKG
Q
V
I
V
-DADQA-GIKPIS-TPRG---VHF-EKDSL
L
I
D
P
L
T
A
I
V
I
K
VGKVAPS
P
K
E
E
L
QADYPKTQSFKG
S
K
T
V
E
K
V
N
R
I
ANKT-S
I
T
P
VVSNKTDSYLTNEANLPKTGDKS
S
K
I
L
S
V
V
G
I
S
I
L
A
S
L
L
A
L
L
G
LSLKRNRHLK
25
HHSearch
98.14
99%
-72
- C1 -
3FAW
9
?
A:
[37-814]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
V
Q
L
K
D
A
Q
Q
T
D
L
T
S
I
Q
--
A
S
F
T
T
L
D
---
K
T
E
I
----
L
K
E
L
K
V
T
-
D
K
N
---
Q
N
A
I
Q
I
S
D
I
T
L
D
T
S
----------
K
S
L
L
I
I
K
G
D
F
N
P
---
K
Q
G
H
-
F
N
I
S
-
Y
N
G
----
N
N
V
T
T
R
Q
S
W
E
F
K
-----
D
Q
L
Y
A
Y
S
---
G
-
N
---
L
G
A
V
L
N
Q
-
D
G
S
K
V
E
A
S
L
W
S
P
S
A
D
S
V
T
M
I
I
Y
D
K
D
N
Q
N
R
V
V
A
T
T
P
-
L
V
K
N
-
N
K
G
V
W
Q
T
I
L
D
T
--
K
--
L
-
G
I
K
-
N
Y
T
G
Y
-
Y
Y
L
Y
E
I
K
------
R
G
K
---------------------------
D
---------
K
V
K
I
L
D
P
Y
A
K
S
L
A
E
W
D
S
N
--
T
V
----------------
N
----------------
D
D
I
K
T
A
K
A
A
F
V
N
P
S
--
Q
L
G
P
Q
N
L
S
F
A
K
-
I
--
A
N
F
----
K
G
R
Q
D
A
V
---
I
Y
E
A
H
V
R
D
F
T
-
S
-
D
Q
S
-
L
D
G
K
L
K
N
Q
L
--------
G
T
F
A
--------
A
-----------
F
-------
S
----
E
K
-----------
L
D
Y
L
Q
K
L
G
V
T
H
I
Q
L
L
P
V
L
S
Y
F
Y
V
N
E
M
-
D
K
-
S
R
----------------------------------------------------
S
-----------------------------------
T
A
Y
T
S
S
D
N
-----------------
N
Y
N
W
G
Y
D
P
Q
S
Y
F
A
L
S
G
M
Y
S
E
K
P
K
-----------------------------------------------------
D
P
S
A
R
I
A
E
L
K
Q
-
L
I
H
D
I
H
-
K
R
-
G
M
G
-
V
I
L
-
D
V
V
Y
N
H
T
--
A
------
K
--
T
------
Y
------
L
F
------
E
D
------------
I
-
E
P
N
Y
Y
H
F
M
-
N
E
D
-
G
S
-
P
R
E
S
F
G
-
G
G
R
-
L
G
T
T
H
A
M
-
S
R
R
V
L
V
D
S
I
K
Y
L
T
S
E
F
K
V
D
G
F
R
F
D
M
M
-
G
D
H
D
----
A
A
-----
A
I
E
-------------------------------
L
A
Y
K
E
A
K
A
--
I
N
P
N
M
I
M
I
G
E
G
W
R
T
F
Q
G
D
Q
G
K
P
V
K
P
A
D
Q
D
W
M
---
K
S
T
D
T
---
V
G
V
F
S
D
D
I
----
R
N
S
L
K
S
G
F
P
N
-
E
-----------------------
G
-----
T
P
A
F
I
T
G
G
P
--------------------
Q
S
L
Q
-----------
G
I
----
F
---------------
K
-------------------------
N
I
----
K
------------------------
A
Q
---------------
P
G
N
----
F
--
E
------
A
-----
D
S
P
G
D
V
V
Q
Y
I
A
A
H
D
N
L
T
L
H
D
---
V
I
A
K
S
I
N
K
D
P
K
V
-------------------------
A
--------------------------
E
E
--
D
I
H
R
R
L
R
--
L
G
-
N
V
M
I
L
T
S
----
Q
G
T
A
F
I
H
S
G
Q
E
Y
G
R
T
K
R
L
L
N
P
D
-----
Y
M
T
K
V
S
D
D
K
L
P
N
K
A
T
L
I
E
A
----
V
K
----
E
Y
P
Y
F
I
H
D
S
-
Y
D
S
S
D
-----
A
I
N
H
F
D
W
A
A
A
T
D
N
------------
N
K
---------------
H
P
I
S
T
K
T
Q
A
Y
T
A
G
-
L
I
T
L
R
R
S
T
D
A
F
R
K
L
S
K
A
E
I
D
-------
R
E
V
S
L
-
I
T
E
V
G
Q
----
G
D
I
K
-
E
-
K
D
L
V
I
A
Y
-------
Q
T
I
D
S
------------
K
---------
G
----
D
I
Y
A
V
F
V
N
A
D
S
K
A
R
-
N
V
---
L
L
G
E
K
Y
K
H
L
L
K
G
Q
V
I
V
-
D
A
D
Q
A
-
G
I
K
P
I
S
-
T
P
R
G
---
V
H
F
-
E
K
D
S
L
L
I
D
P
L
T
A
I
V
I
K
V
G
----------------------------------------------------------------------------------------------
1
PsiBlast_PDB
98.14
99%
-72
- C1 -
3FAW
9
?
A:
[37-814]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
V
Q
L
K
D
A
Q
Q
T
D
L
T
S
I
Q
--
A
S
F
T
T
L
D
---
K
T
E
I
----
L
K
E
L
K
V
T
-
D
K
N
---
Q
N
A
I
Q
I
S
D
I
T
L
D
T
S
----------
K
S
L
L
I
I
K
G
D
F
N
P
---
K
Q
G
H
-
F
N
I
S
-
Y
N
G
----
N
N
V
T
T
R
Q
S
W
E
F
K
-----
D
Q
L
Y
A
Y
S
---
G
-
N
---
L
G
A
V
L
N
Q
-
D
G
S
K
V
E
A
S
L
W
S
P
S
A
D
S
V
T
M
I
I
Y
D
K
D
N
Q
N
R
V
V
A
T
T
P
-
L
V
K
N
-
N
K
G
V
W
Q
T
I
L
D
T
--
K
--
L
-
G
I
K
-
N
Y
T
G
Y
-
Y
Y
L
Y
E
I
K
------
R
G
K
---------------------------
D
---------
K
V
K
I
L
D
P
Y
A
K
S
L
A
E
W
D
S
N
--
T
V
----------------
N
----------------
D
D
I
K
T
A
K
A
A
F
V
N
P
S
--
Q
L
G
P
Q
N
L
S
F
A
K
-
I
--
A
N
F
----
K
G
R
Q
D
A
V
---
I
Y
E
A
H
V
R
D
F
T
-
S
-
D
Q
S
-
L
D
G
K
L
K
N
Q
L
--------
G
T
F
A
--------
A
-----------
F
-------
S
----
E
K
-----------
L
D
Y
L
Q
K
L
G
V
T
H
I
Q
L
L
P
V
L
S
Y
F
Y
V
N
E
M
-
D
K
-
S
R
----------------------------------------------------
S
-----------------------------------
T
A
Y
T
S
S
D
N
-----------------
N
Y
N
W
G
Y
D
P
Q
S
Y
F
A
L
S
G
M
Y
S
E
K
P
K
-----------------------------------------------------
D
P
S
A
R
I
A
E
L
K
Q
-
L
I
H
D
I
H
-
K
R
-
G
M
G
-
V
I
L
-
D
V
V
Y
N
H
T
--
A
------
K
--
T
------
Y
------
L
F
------
E
D
------------
I
-
E
P
N
Y
Y
H
F
M
-
N
E
D
-
G
S
-
P
R
E
S
F
G
-
G
G
R
-
L
G
T
T
H
A
M
-
S
R
R
V
L
V
D
S
I
K
Y
L
T
S
E
F
K
V
D
G
F
R
F
D
M
M
-
G
D
H
D
----
A
A
-----
A
I
E
-------------------------------
L
A
Y
K
E
A
K
A
--
I
N
P
N
M
I
M
I
G
E
G
W
R
T
F
Q
G
D
Q
G
K
P
V
K
P
A
D
Q
D
W
M
---
K
S
T
D
T
---
V
G
V
F
S
D
D
I
----
R
N
S
L
K
S
G
F
P
N
-
E
-----------------------
G
-----
T
P
A
F
I
T
G
G
P
--------------------
Q
S
L
Q
-----------
G
I
----
F
---------------
K
-------------------------
N
I
----
K
------------------------
A
Q
---------------
P
G
N
----
F
--
E
------
A
-----
D
S
P
G
D
V
V
Q
Y
I
A
A
H
D
N
L
T
L
H
D
---
V
I
A
K
S
I
N
K
D
P
K
V
-------------------------
A
--------------------------
E
E
--
D
I
H
R
R
L
R
--
L
G
-
N
V
M
I
L
T
S
----
Q
G
T
A
F
I
H
S
G
Q
E
Y
G
R
T
K
R
L
L
N
P
D
-----
Y
M
T
K
V
S
D
D
K
L
P
N
K
A
T
L
I
E
A
----
V
K
----
E
Y
P
Y
F
I
H
D
S
-
Y
D
S
S
D
-----
A
I
N
H
F
D
W
A
A
A
T
D
N
------------
N
K
---------------
H
P
I
S
T
K
T
Q
A
Y
T
A
G
-
L
I
T
L
R
R
S
T
D
A
F
R
K
L
S
K
A
E
I
D
-------
R
E
V
S
L
-
I
T
E
V
G
Q
----
G
D
I
K
-
E
-
K
D
L
V
I
A
Y
-------
Q
T
I
D
S
------------
K
---------
G
----
D
I
Y
A
V
F
V
N
A
D
S
K
A
R
-
N
V
---
L
L
G
E
K
Y
K
H
L
L
K
G
Q
V
I
V
-
D
A
D
Q
A
-
G
I
K
P
I
S
-
T
P
R
G
---
V
H
F
-
E
K
D
S
L
L
I
D
P
L
T
A
I
V
I
K
V
G
----------------------------------------------------------------------------------------------
46
Fugue
98.04
99%
-72
- C1 -
3FAW
9
?
A:
[37-814]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
V
Q
L
K
D
A
Q
Q
T
D
L
T
S
I
Q
--
A
S
F
T
T
---
L
D
K
T
E
I
----
L
K
E
L
K
V
T
-
D
K
N
---
Q
N
A
I
Q
I
S
D
I
T
L
D
T
S
----------
K
S
L
L
I
I
K
G
D
F
N
P
---
K
Q
G
H
-
F
N
I
S
-
Y
N
G
----
N
N
V
T
T
R
Q
S
W
E
F
K
-----
D
Q
L
Y
A
Y
S
---
G
-
N
---
L
G
A
V
L
N
Q
-
D
G
S
K
V
E
A
S
L
W
S
P
S
A
D
S
V
T
M
I
I
Y
D
K
D
N
Q
N
R
V
V
A
T
T
P
-
L
V
K
N
-
N
K
G
V
W
Q
T
I
L
D
T
--
K
--
L
-
G
I
K
-
N
Y
T
G
Y
-
Y
Y
L
Y
E
I
K
------
R
G
K
---------------------------
D
---------
K
V
K
I
L
D
P
Y
A
K
S
L
A
E
W
D
S
N
--
T
V
----------------
N
----------------
D
D
I
K
T
A
K
A
A
F
V
N
P
S
--
Q
L
G
P
Q
N
L
S
F
A
K
-
I
--
A
N
F
----
K
G
R
Q
D
A
V
---
I
Y
E
A
H
V
R
D
F
T
-
S
-
D
Q
S
-
L
D
G
K
L
K
N
Q
L
--------
G
T
F
A
--------
A
-----------
F
-------
S
----
E
K
-----------
L
D
Y
L
Q
K
L
G
V
T
H
I
Q
L
L
P
V
L
S
Y
F
Y
V
N
E
M
-
D
K
-
S
R
----------------------------------------------------
S
-----------------------------------
T
A
Y
T
S
S
D
N
-----------------
N
Y
N
W
G
Y
D
P
Q
S
Y
F
A
L
S
G
M
Y
S
E
K
P
K
-----------------------------------------------------
D
P
S
A
R
I
A
E
L
K
Q
-
L
I
H
D
I
H
-
K
R
-
G
M
G
-
V
I
L
-
D
V
V
Y
N
H
T
--
A
------
K
--
T
------
Y
------
L
F
------
E
D
------------
I
-
E
P
N
Y
Y
H
F
M
-
N
E
D
-
G
S
-
P
R
E
S
F
G
-
G
G
R
-
L
G
T
T
H
A
M
-
S
R
R
V
L
V
D
S
I
K
Y
L
T
S
E
F
K
V
D
G
F
R
F
D
M
M
-
G
D
H
D
----
A
A
-----
A
I
E
-------------------------------
L
A
Y
K
E
A
K
A
--
I
N
P
N
M
I
M
I
G
E
G
W
R
T
F
Q
G
D
Q
G
K
P
V
K
P
A
D
Q
D
W
M
---
K
S
T
D
T
---
V
G
V
F
S
D
D
I
----
R
N
S
L
K
S
G
F
P
N
-
E
-----------------------
G
-----
T
P
A
F
I
T
G
G
P
--------------------
Q
S
L
Q
-----------
G
I
----
F
---------------
K
-------------------------
N
I
----
K
------------------------
A
Q
---------------
P
G
N
----
F
--
E
------
A
-----
D
S
P
G
D
V
V
Q
Y
I
A
A
H
D
N
L
T
L
H
D
---
V
I
A
K
S
I
N
K
D
P
K
V
-------------------------
A
--------------------------
E
E
--
D
I
H
R
R
L
R
--
L
G
-
N
V
M
I
L
T
S
----
Q
G
T
A
F
I
H
S
G
Q
E
Y
G
R
T
K
R
L
L
N
P
D
-----
Y
M
T
K
V
S
D
D
K
L
P
N
K
A
T
L
I
E
A
----
V
K
----
E
Y
P
Y
F
I
H
D
S
-
Y
D
S
S
D
-----
A
I
N
H
F
D
W
A
A
A
T
D
N
------------
N
K
---------------
H
P
I
S
T
K
T
Q
A
Y
T
A
G
-
L
I
T
L
R
R
S
T
D
A
F
R
K
L
S
K
A
E
I
D
-------
R
E
V
S
L
-
I
T
E
V
G
Q
----
G
D
I
K
-
E
-
K
D
L
V
I
A
Y
-------
Q
T
I
D
S
------------
K
---------
G
----
D
I
Y
A
V
F
V
N
A
D
S
K
A
R
-
N
V
---
L
L
G
E
K
Y
K
H
L
L
K
G
Q
V
I
V
-
D
A
D
Q
A
-
G
I
K
P
I
S
-
T
P
R
G
---
V
H
F
-
E
K
D
S
L
L
I
D
P
L
T
A
I
V
I
K
V
G
----------------------------------------------------------------------------------------------
2
PsiBlast_PDB
96.73
99%
-72
- C1 -
3FAX
6
?
A:
[38-815]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
Q
L
K
D
A
Q
Q
T
D
L
T
S
I
Q
--
A
S
F
T
T
L
D
G
V
D
K
T
E
I
----
L
K
E
L
K
V
T
-
D
K
----
Q
N
A
I
Q
I
S
D
I
T
L
D
T
S
----------
K
S
L
L
I
I
K
G
D
F
N
P
---
K
Q
G
H
-
F
N
I
S
-
Y
N
-----
N
N
V
T
T
R
Q
S
W
E
F
K
-----
D
Q
L
Y
A
Y
S
---
G
-
N
---
L
G
A
V
L
N
Q
-
D
G
S
K
V
E
A
S
L
W
S
P
S
A
D
S
V
T
M
I
I
Y
D
K
D
N
Q
N
R
V
V
A
T
T
P
-
L
V
K
N
-
N
K
G
V
W
Q
T
I
L
D
T
--
K
--
L
-
G
I
K
-
N
Y
T
G
Y
-
Y
Y
L
Y
E
I
K
------
R
G
----------------------------
D
---------
K
V
K
I
L
D
P
Y
A
K
S
L
A
E
W
D
S
N
--
T
V
----------------
N
----------------
D
D
I
K
T
A
K
A
A
F
V
N
P
S
--
Q
L
G
P
Q
N
L
S
F
A
K
-
I
--
A
N
F
----
K
G
R
Q
D
A
V
---
I
Y
E
A
H
V
R
D
F
T
-
S
-
D
Q
S
-
L
D
G
--
K
N
Q
L
--------
G
T
F
A
--------
A
-----------
F
-------
S
----
E
K
-----------
L
D
Y
L
Q
K
L
G
V
T
H
I
Q
L
L
P
V
L
S
Y
F
Y
V
N
E
M
-
D
K
-
S
R
----------------------------------------------------
S
-----------------------------------
T
A
Y
T
S
S
D
N
-----------------
N
Y
N
W
G
Y
D
P
Q
S
Y
F
A
L
S
G
M
Y
S
E
K
P
K
-----------------------------------------------------
D
P
S
A
R
I
A
E
L
K
Q
-
L
I
H
D
I
H
-
K
R
-
G
M
G
-
V
I
L
-
D
V
V
Y
N
H
T
--
A
------
K
--
T
------
Y
------
L
F
------
E
D
------------
I
-
E
P
N
Y
Y
H
F
M
-
N
E
D
-
G
S
-
P
R
E
S
F
G
-
G
G
R
-
L
G
T
T
H
A
M
-
S
R
R
V
L
V
D
S
I
K
Y
L
T
S
E
F
K
V
D
G
F
R
F
D
M
M
-
G
D
H
D
----
A
A
-----
A
I
E
-------------------------------
L
A
Y
K
E
A
K
A
--
I
N
P
N
M
I
M
I
G
E
G
W
R
T
F
Q
G
D
Q
G
K
P
V
K
P
A
D
Q
D
W
M
---
K
S
T
D
T
---
V
G
V
F
S
D
D
I
----
R
N
S
L
K
S
G
F
P
N
-
E
-----------------------
G
-----
T
P
A
F
I
T
G
G
P
--------------------
Q
S
L
Q
-----------
G
I
----
F
---------------
K
-------------------------
N
I
----
K
------------------------
A
Q
---------------
P
G
N
----
F
--
E
------
A
-----
D
S
P
G
D
V
V
Q
Y
I
A
A
H
D
N
L
T
L
H
D
---
V
I
A
K
S
I
N
K
D
P
K
V
-------------------------
A
--------------------------
E
E
--
D
I
H
R
R
L
R
--
L
G
-
N
V
M
I
L
T
S
----
Q
G
T
A
F
I
H
S
G
Q
E
Y
G
R
T
K
R
L
L
N
P
D
-----
Y
M
T
K
V
S
-
D
K
L
P
N
K
A
T
L
I
E
A
----
V
K
----
E
Y
P
Y
F
I
H
D
S
-
Y
D
S
S
D
-----
A
I
N
H
F
D
W
A
A
A
T
D
N
------------
N
K
---------------
H
P
I
S
T
K
T
Q
A
Y
T
A
G
-
L
I
T
L
R
R
S
T
D
A
F
R
K
L
S
K
A
E
I
D
-------
R
E
V
S
L
-
I
T
E
V
G
Q
----
G
D
I
K
-
E
-
K
D
L
V
I
A
Y
-------
Q
T
I
D
S
----------------------
G
----
D
I
Y
A
V
F
V
N
A
D
S
K
A
R
-
N
V
---
L
L
G
E
K
Y
K
H
L
L
K
G
Q
V
I
V
-
D
A
D
Q
A
-
G
I
K
P
I
S
-
T
P
R
G
---
V
H
F
-
E
K
D
S
L
L
I
D
P
L
T
A
I
V
I
K
V
G
K
---------------------------------------------------------------------------------------------
4
PsiBlast_PDB
81.95
61%
-65
- C1 -
2YA2
4
?
A:
[2-707]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
W
R
L
K
-----
D
E
T
Y
S
Y
D
---
G
-
K
---
L
G
A
D
L
K
E
-
E
G
K
Q
V
D
L
T
L
W
S
P
S
A
D
K
V
S
V
V
V
Y
D
K
N
D
P
D
K
V
V
G
T
V
A
-
L
E
K
G
-
E
R
G
T
W
K
Q
T
L
D
S
TN
K
--
L
-
G
I
T
-
D
F
T
G
Y
-
Y
Y
Q
Y
Q
I
E
------
R
Q
G
---------------------------
K
---------
T
V
L
A
L
D
P
Y
A
K
S
L
A
A
W
N
S
D
DS
K
I
----------------
D
----------------
D
A
H
K
V
A
K
A
A
F
V
D
P
A
--
K
L
G
P
Q
D
L
T
Y
G
K
-
I
--
H
N
F
----
K
T
R
E
D
A
V
---
I
Y
E
A
H
V
R
D
F
T
-
S
-
D
P
A
-
I
A
K
D
L
T
K
P
F
--------
G
T
F
E
--------
A
-----------
F
-------
I
----
E
K
-----------
L
D
Y
L
K
D
L
G
V
T
H
I
Q
L
L
P
V
L
S
Y
Y
F
V
N
E
L
K
N
H
-
E
R
----------------------------------------------------
L
-----------------------------------
S
D
Y
A
S
S
N
S
-----------------
N
Y
N
W
G
Y
D
P
Q
N
Y
F
S
L
T
G
M
Y
S
S
D
P
K
-----------------------------------------------------
N
P
E
K
R
I
A
E
F
K
N
-
L
I
N
E
I
H
-
K
R
-
G
M
G
-
A
I
L
-
D
V
V
Y
N
H
T
--
A
------
K
--
V
------
D
------
L
F
------
E
D
------------
L
-
E
P
N
Y
Y
H
F
M
-
D
A
D
-
G
T
-
P
R
T
S
F
G
-
G
G
R
-
L
G
T
T
H
H
M
-
T
K
R
L
L
I
D
S
I
K
Y
L
V
D
T
Y
K
V
D
G
F
R
F
D
M
M
-
G
D
H
D
----
A
A
-----
S
I
E
-------------------------------
E
A
Y
K
A
A
R
A
--
L
N
P
N
L
I
M
L
G
E
G
W
R
T
Y
A
G
D
E
N
M
P
T
K
A
A
D
Q
D
W
M
---
K
H
T
D
T
---
V
A
V
F
S
D
D
I
----
R
N
N
L
K
S
G
Y
P
N
-
E
-----------------------
G
-----
Q
P
A
F
I
T
G
G
K
--------------------
R
D
V
N
-----------
T
I
----
F
---------------
K
-------------------------
N
L
----
I
------------------------
A
Q
---------------
P
T
N
----
F
--
E
------
A
-----
D
S
P
G
D
V
I
Q
Y
I
A
A
H
D
D
L
T
L
F
D
---
I
I
A
Q
S
I
K
K
D
P
S
K
-------------------------
A
--------------------------
E
N
Y
A
E
I
H
R
R
L
R
--
L
G
-
N
L
M
V
L
T
A
----
Q
G
T
P
F
I
H
S
G
Q
E
Y
G
R
T
K
Q
F
R
N
P
A
-----
Y
R
T
P
V
A
E
D
K
V
P
N
K
S
H
L
L
R
D
----
K
D
GNPF
D
Y
P
Y
F
I
H
D
S
-
Y
D
S
S
D
-----
A
V
N
K
F
D
W
T
K
A
T
D
G
------------
K
A
---------------
Y
P
E
N
V
K
S
R
D
Y
M
K
G
-
L
I
A
L
R
Q
S
T
D
A
F
R
L
K
S
L
Q
D
I
K
-------
D
R
V
H
L
-
I
T
V
P
G
Q
----
N
G
V
E
-
K
-
E
D
V
V
I
G
Y
-------
Q
I
T
A
P
------------
N
---------
G
----
D
I
Y
A
V
F
V
N
A
D
E
K
A
R
-
E
F
---
N
L
G
T
A
F
A
H
L
R
N
A
E
V
L
A
-
D
E
N
Q
A
-
G
P
V
G
I
A
-
N
P
K
G
---
L
E
W
-
T
E
K
G
L
K
L
N
A
L
T
A
T
V
L
R
V
S
Q
N
--------------------------------------------------------------------------------------------
3
PsiBlast_PDB
81.86
61%
-63
- C1 -
2YA0
7
?
A:
[1-706]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
W
R
L
K
-----
D
E
T
Y
S
Y
D
---
G
-
K
---
L
G
A
D
L
K
E
-
E
G
K
Q
V
D
L
T
L
W
S
P
S
A
D
K
V
S
V
V
V
Y
D
K
N
D
P
D
K
V
V
G
T
V
A
-
L
E
K
G
-
E
R
G
T
W
K
Q
T
L
D
S
TN
K
--
L
-
G
I
T
-
D
F
T
G
Y
-
Y
Y
Q
Y
Q
I
E
------
R
Q
G
---------------------------
K
---------
T
V
L
A
L
D
P
Y
A
K
S
L
A
A
W
N
S
D
DS
K
I
----------------
D
----------------
D
A
H
K
V
A
K
A
A
F
V
D
P
A
--
K
L
G
P
Q
D
L
T
Y
G
K
-
I
--
H
N
F
----
K
T
R
E
D
A
V
---
I
Y
E
A
H
V
R
D
F
T
-
S
-
D
P
A
-
I
A
K
D
L
T
K
P
F
--------
G
T
F
E
--------
A
-----------
F
-------
I
----
E
K
-----------
L
D
Y
L
K
D
L
G
V
T
H
I
Q
L
L
P
V
L
S
Y
Y
F
V
N
E
L
K
N
H
-
E
R
----------------------------------------------------
L
-----------------------------------
S
D
Y
A
S
S
N
S
-----------------
N
Y
N
W
G
Y
D
P
Q
N
Y
F
S
L
T
G
M
Y
S
S
D
P
K
-----------------------------------------------------
N
P
E
K
R
I
A
E
F
K
N
-
L
I
N
E
I
H
-
K
R
-
G
M
G
-
A
I
L
-
D
V
V
Y
N
H
T
--
A
------
K
--
V
------
D
------
L
F
------
E
D
------------
L
-
E
P
N
Y
Y
H
F
M
-
D
A
D
-
G
T
-
P
R
T
S
F
G
-
G
G
R
-
L
G
T
T
H
H
M
-
T
K
R
L
L
I
D
S
I
K
Y
L
V
D
T
Y
K
V
D
G
F
R
F
D
M
M
-
G
D
H
D
----
A
A
-----
S
I
E
-------------------------------
E
A
Y
K
A
A
R
A
--
L
N
P
N
L
I
M
L
G
E
G
W
R
T
Y
A
G
D
E
N
M
P
T
K
A
A
D
Q
D
W
M
---
K
H
T
D
T
---
V
A
V
F
S
D
D
I
----
R
N
N
L
K
S
G
Y
P
N
-
E
-----------------------
G
-----
Q
P
A
F
I
T
G
G
K
--------------------
R
D
V
N
-----------
T
I
----
F
---------------
K
-------------------------
N
L
----
I
------------------------
A
Q
---------------
P
T
N
----
F
--
E
------
A
-----
D
S
P
G
D
V
I
Q
Y
I
A
A
H
D
N
L
T
L
F
D
---
I
I
A
Q
S
I
K
K
D
P
S
K
-------------------------
A
--------------------------
E
N
Y
A
E
I
H
R
R
L
R
--
L
G
-
N
L
M
V
L
T
A
----
Q
G
T
P
F
I
H
S
G
Q
E
Y
G
R
T
K
Q
F
R
N
P
A
-----
Y
R
T
P
V
A
E
D
K
V
P
N
K
S
H
L
L
R
D
----
K
D
GNPF
D
Y
P
Y
F
I
H
D
S
-
Y
D
S
S
D
-----
A
V
N
K
F
D
W
T
K
A
T
D
G
------------
K
A
---------------
Y
P
E
N
V
K
S
R
D
Y
M
K
G
-
L
I
A
L
R
Q
S
T
D
A
F
R
L
K
S
L
Q
D
I
K
-------
D
R
V
H
L
-
I
T
V
P
G
Q
----
N
G
V
E
-
K
-
E
D
V
V
I
G
Y
-------
Q
I
T
A
P
------------
N
---------
G
----
D
I
Y
A
V
F
V
N
A
D
E
K
A
R
-
E
F
---
N
L
G
T
A
F
A
H
L
R
N
A
E
V
L
A
-
D
E
N
Q
A
-
G
P
V
G
I
A
-
N
P
K
G
---
L
E
W
-
T
E
K
G
L
K
L
N
A
L
T
A
T
V
L
R
V
S
Q
N
G
T
S
H
E
S
T
-------------------------------------------------------------------------------------
29
HHSearch
81.19
62%
-62
- C1 -
2YA0
7
?
A:
[2-709]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
R
L
K
-----
D
E
T
Y
S
Y
D
---
G
-
K
---
L
G
A
D
L
K
E
-
E
G
K
Q
V
D
L
T
L
W
S
P
S
A
D
K
V
S
V
V
V
Y
D
K
N
D
P
D
K
V
V
G
T
V
A
-
L
E
K
G
-
E
R
G
T
W
K
Q
T
L
D
S
--
T
NK
L
-
G
I
T
-
D
F
T
G
Y
-
Y
Y
Q
Y
Q
I
E
------
R
Q
G
---------------------------
K
---------
T
V
L
A
L
D
P
Y
A
K
S
L
A
A
W
N
S
D
--
D
S
KI--------------
D
----------------
D
A
H
K
V
A
K
A
A
F
V
D
P
A
--
K
L
G
P
Q
D
L
T
Y
G
K
-
I
--
H
N
F
----
K
T
R
E
D
A
V
---
I
Y
E
A
H
V
R
D
F
T
-
S
-
D
P
A
-
I
A
K
D
L
T
K
P
F
--------
G
T
F
E
--------
A
-----------
F
-------
I
----
E
K
-----------
L
D
Y
L
K
D
L
G
V
T
H
I
Q
L
L
P
V
L
S
Y
Y
F
V
N
E
L
-
K
N
H
E
R
----------------------------------------------------
L
-----------------------------------
S
D
Y
A
S
S
N
S
-----------------
N
Y
N
W
G
Y
D
P
Q
N
Y
F
S
L
T
G
M
Y
S
S
D
P
K
-----------------------------------------------------
N
P
E
K
R
I
A
E
F
K
N
-
L
I
N
E
I
H
-
K
R
-
G
M
G
-
A
I
L
-
D
V
V
Y
N
H
T
--
A
------
K
--
V
------
D
------
L
F
------
E
D
------------
L
-
E
P
N
Y
Y
H
F
M
-
D
A
D
-
G
T
-
P
R
T
S
F
G
-
G
G
R
-
L
G
T
T
H
H
M
-
T
K
R
L
L
I
D
S
I
K
Y
L
V
D
T
Y
K
V
D
G
F
R
F
D
M
M
-
G
D
H
D
----
A
A
-----
S
I
E
-------------------------------
E
A
Y
K
A
A
R
A
--
L
N
P
N
L
I
M
L
G
E
G
W
R
T
Y
A
G
D
E
N
M
P
T
K
A
A
D
Q
D
W
M
---
K
H
T
D
T
---
V
A
V
F
S
D
D
I
----
R
N
N
L
K
S
G
Y
P
N
-
E
-----------------------
G
-----
Q
P
A
F
I
T
G
G
K
--------------------
R
D
V
N
-----------
T
I
----
F
---------------
K
-------------------------
N
L
----
I
------------------------
A
Q
---------------
P
T
N
----
F
--
E
------
A
-----
D
S
P
G
D
V
I
Q
Y
I
A
A
H
D
N
L
T
L
F
D
---
I
I
A
Q
S
I
K
K
D
P
S
K
-------------------------
A
E
N
------------------------
Y
A
--
E
I
H
R
R
L
R
--
L
G
-
N
L
M
V
L
T
A
----
Q
G
T
P
F
I
H
S
G
Q
E
Y
G
R
T
K
Q
F
R
N
P
A
-----
Y
R
T
P
V
A
E
D
K
V
P
N
K
S
H
L
L
R
D
KDGN
P
F
----
D
Y
P
Y
F
I
H
D
S
-
Y
D
S
S
D
-----
A
V
N
K
F
D
W
T
K
A
T
D
G
------------
K
A
---------------
Y
P
E
N
V
K
S
R
D
Y
M
K
G
-
L
I
A
L
R
Q
S
T
D
A
F
R
L
K
S
L
Q
D
I
K
-------
D
R
V
H
L
-
I
T
V
P
G
Q
----
N
G
V
E
-
K
-
E
D
V
V
I
G
Y
-------
Q
I
T
A
P
------------
N
---------
G
----
D
I
Y
A
V
F
V
N
A
D
E
K
A
R
-
E
F
---
N
L
G
T
A
F
A
H
L
R
N
A
E
V
L
A
-
D
E
N
Q
A
-
G
P
V
G
I
A
-
N
P
K
G
---
L
E
W
-
T
E
K
G
L
K
L
N
A
L
T
A
T
V
L
R
V
S
Q
N
G
T
S
H
E
S
T
-------------------------------------------------------------------------------------
27
HHSearch
68.94
26%
-53
- C1 -
2FHF
7
PULA_ENTAE
A:
[49-1074]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
S
A
R
Q
A
V
I
H
L
V
D
I
A
G
ITS
S
T
P
A
D
Y
A
T
K
N
L
Y
L
W
N
-
N
E
T
C
DALSA
P
V
A
D
W
N
D
V
S
T
T
P
T
G
S
D
K
Y
G
P
Y
W
V
I
P
L
T
K
E
S
G
C
I
N
V
I
V
R
D
G
T
N
--
K
L
I
---
D
S
D
L
R
V
S
F
S
D
F
T
D
R
T
V
S
V
I
A
G
N
S
A
V
Y
-
D
S
R
A
D
A
F
R
A
AF
G
V
A
L
A
D
A
H
W
V
D
K
T
T
L
L
--
W
P
G
G
E
N
--
K
P
I
V
R
L
Y
Y
S
H
S
S
K
V
A
A
D
-
S
N
G
EFS
D
K
Y
V
K
L
T
P
T
T
V
N
Q
Q
V
S
M
R
FPHLAS
Y
P
A
F
K
L
P
D
D
V
N
V
D
E
L
L
Q
G
E
-
T
V
A
I
A
A
E
S
DGIL
S
S
A
T
Q
V
Q
T
A
G
V
L
-----
D
D
T
Y
A
A
A
A
E
A
L
-
S
---
Y
G
A
Q
L
T
D
-
S
--
G
V
T
F
R
V
W
A
P
T
A
Q
Q
V
E
L
V
I
Y
S
A
D
K
K
--
V
I
A
S
H
P
-
M
T
R
D
S
A
S
G
A
W
S
W
Q
G
G
S
-----------
D
L
K
G
A
-
F
Y
R
Y
A
M
T
------
V
Y
H
PQSRKV---------------------
E
---------
Q
Y
E
V
T
D
P
Y
A
H
S
L
S
T
N
S
E
--------------------------------------------
Y
S
Q
V
V
D
L
N
DS
A
L
K
P
E
G
W
D
G
L
T
-
M
--
P
H
A
QKT
K
A
D
L
A
K
M
T
---
I
H
E
S
H
I
R
D
L
S
-
A
-
W
D
Q
T
V
P
A
E
L
R
-----------
G
K
Y
L
--------
A
-----------
L
TAQES
N
M
V
----
Q
H
-----------
L
K
Q
L
S
A
S
G
V
T
H
I
E
L
L
P
V
F
D
L
A
T
V
N
E
F
-
S
D
-
K
V
ADIQQP
F
S
R
L
C
E
V
N
SAVKSSEFAGYCDSGST
V
E
E
V
L
T
Q
L
KQNDSKDNP
Q
V
Q
A
L
-----------------------------------
N
T
L
V
A
Q
T
D
-----------------
S
Y
N
W
G
Y
D
P
F
H
Y
T
V
P
E
G
S
Y
A
T
D
P
------------------------------------------------------
E
G
T
A
R
I
K
E
F
R
T
-
M
I
Q
A
I
K
Q
D
L
-
G
M
N
-
V
I
M
-
D
V
V
Y
N
H
T
--
N
------
A
--
A
------
G
PTDRTS
V
L
------
D
K
------------
I
-
V
P
W
Y
Y
Q
R
L
-
N
E
T
T
G
S
-
V
E
S
A
T
C
-
C
S
D
-
S
A
P
E
H
R
M
-
F
A
K
L
I
A
D
S
L
A
V
W
T
T
D
Y
K
I
D
G
F
R
F
D
L
M
-
L
Y
H
P
----
K
A
-----
Q
I
L
-------------------------------
S
A
W
E
R
I
K
A
--
L
N
P
D
I
Y
F
F
G
E
G
W
D
S
N
Q
S
D
--
R
-
F
E
I
A
S
Q
I
N
L
---
K
-
G
T
G
---
I
G
T
F
S
D
R
L
----
R
D
A
V
R
G
G
G
P
F
D
S
-----------------------
G
D
A
L
R
Q
N
Q
G
V
G
S
G
A
G
--------------------
V
L
P
N
ELTTLS
D
D
Q
A
R
H
L
A
D
L
T
R
---------------
L
-------------------------
G
M
----
A
GNLAD
F
V
L
I
D
KDG
A
V
K
R
GSEIDYN
G
A
---------------
P
G
G
----
Y
---------
A
-----
A
D
P
T
E
V
V
N
Y
V
S
K
H
D
N
Q
T
L
W
D
---
M
I
S
Y
K
A
A
Q
E
--
A
-------------------------
D
--------------------------
L
D
--
T
R
V
R
M
Q
A
--
V
S
-
L
A
T
V
M
L
G
----
Q
G
I
A
F
D
Q
Q
G
S
E
L
L
R
S
K
S
F
T
-------------------------------------------
R
D
S
-
Y
D
S
G
D
-----
W
F
N
R
V
D
Y
S
L
Q
D
N
N
YNVGMPRSSDDG
S
N
Y
D
I
I
A
R
V
KDAVATPG
E
T
E
L
K
Q
M
T
A
F
Y
Q
E
-
L
T
A
L
R
K
S
S
P
L
F
T
L
G
D
G
A
T
V
M
-------
K
R
V
D
F
-
R
N
T
G
A
--------
D
-
Q
-
Q
T
G
L
L
V
M
-------
T
I
D
D
G
------------
M
QAGASLDSR
V
----
D
G
I
V
V
A
I
N
A
A
P
E
S
R
-
T
L
---
Q
D
F
A
----
G
T
S
L
Q
L
S
A
-
I
Q
Q
A
A
-
G
D
R
S
L
A
-
S
G
-
V
---
Q
V
A
-
A
D
G
S
V
T
L
P
A
W
S
V
A
V
L
E
L
P
Q
G
E
S
Q
G
A
G
L
P
V
S
S
K
--------------------------------------------------------------------------------
30
HHSearch
65.04
30%
-58
- C1 -
3WDH
1
?
A:
[93-709]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
V
M
R
T
K
A
F
-----
D
D
L
Y
A
Y
D
---
G
N
D
---
L
G
A
T
Y
D
P
-
E
--
K
T
T
F
K
V
W
A
P
T
A
T
D
V
L
L
K
L
I
H
P
T
T
K
E
--
E
T
T
Y
V
-
M
T
R
E
-
K
K
G
L
W
T
Y
T
V
Y
D
-----------
D
V
E
R
F
-
L
Y
T
Y
M
T
Y
------
V
N
F
---------------------------
I
---------
W
R
E
A
V
D
P
Y
A
K
S
V
S
V
N
G
T
--------------------------------------------
Y
G
V
V
V
D
L
A
--
K
T
N
I
P
K
P
---
S
-
M
--
S
L
F
----
I
S
M
T
D
A
I
---
I
Y
E
M
H
I
R
D
F
T
-
I
-
H
H
E
-
S
G
V
R
Q
K
-----------
G
K
Y
V
--------
G
L
T
ERGTTGPNG
T
-------
L
----
T
G
-----------
L
S
Y
I
K
Q
L
G
V
T
H
V
Q
L
M
P
V
Q
D
F
E
G
V
D
E
L
-
Q
P
-------------------------------------------------------------------------------------------------
L
K
-----------------
M
Y
N
W
G
Y
N
T
V
H
Y
N
A
P
E
G
S
Y
A
T
D
P
D
-----------------------------------------------------
D
P
Y
A
R
I
I
E
L
K
R
-
A
I
R
A
F
Q
-
Q
E
-
G
I
R
-
V
I
L
-
D
V
V
Y
N
H
V
--
Y
------
V
--
R
------
E
TS----
S
F
------
E
H
------------
L
-
V
P
G
Y
Y
F
R
Y
-
E
R
N
-
G
Y
-
P
S
N
G
T
G
V
G
N
D
-
L
A
S
E
R
K
M
-
V
K
K
F
I
I
D
S
V
T
Y
W
L
K
E
Y
G
V
D
G
F
R
F
D
L
M
-
G
I
L
D
----
I
D
-----
T
M
N
-------------------------------
D
V
R
R
A
I
D
E
--
I
D
P
T
V
I
I
L
G
E
G
W
D
L
A
T
P
L
P
S
--
E
K
K
T
T
I
A
N
A
---
K
H
T
P
R
---
I
A
Y
F
N
D
R
F
----
R
D
Y
V
K
G
S
T
F
D
-
I
-----------------------
H
-----
E
R
G
F
A
L
G
D
C
--------------------
S
Y
K
E
-----------
A
V
----
I
---------------
G
-------------------------
A
I
----
R
------------------------
G
S
---------------
I
H
L
----
F
---------------
F
S
P
R
Q
S
V
N
Y
V
E
C
H
D
N
H
T
L
W
D
---
K
M
A
V
A
N
A
H
E
----------------------------
S
--------------------------
E
Y
--
I
R
R
K
R
Q
K
--
L
A
-
T
A
I
V
L
L
S
----
Q
G
I
P
F
L
H
S
G
Q
E
F
Y
R
T
K
K
G
V
-------------------------------------------
E
N
S
-
Y
N
S
P
D
-----
E
V
N
Q
V
D
W
N
E
K
S
---------------------------------
R
W
E
E
D
V
R
E
I
M
K
-
L
I
E
L
R
K
K
H
G
A
F
R
F
L
T
A
D
Q
V
R
-------
R
H
M
K
F
-
Y
D
T
--------------
H
P
S
V
I
A
Y
-------
Q
L
V
D
V
------------
G
VYGP-----
W
----
K
Q
I
V
V
V
Y
H
N
E
E
K
K
A
-
M
L
---
P
L
A
-----
D
G
K
W
K
V
M
F
-
S
S
E
----
L
------------
G
N
V
-
C
E
Q
F
I
E
I
N
G
I
G
A
W
V
L
I
Q
C
----------------------------------------------------------------------------------------------
48
Fugue
63.45
27%
-48
- C1 -
2E8Y
3
PULA_BACSU
A:
[1-712]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
V
S
I
R
R
S
F
E
A
Y
V
D
D
M
N
--
I
I
T
V
L
I
P
A
E
Q
K
E
I
M
----
T
P
P
F
R
L
E
T
E
I
T
---
D
F
P
L
A
V
R
E
E
Y
S
L
E
A
----------
K
Y
K
Y
V
C
V
S
D
H
P
V
---
T
F
G
K
I
H
C
V
R
-
A
S
S
----
G
H
K
T
D
L
Q
I
G
A
V
I
RT
A
A
F
D
D
E
F
Y
Y
D
---
G
-
E
---
L
G
A
V
Y
T
A
-
D
--
H
T
V
F
K
V
W
A
P
A
A
T
S
A
A
V
K
L
S
H
P
N
K
S
G
---
R
T
F
Q
-
M
T
R
L
-
E
K
G
V
Y
A
V
T
V
T
----------
G
-
D
L
H
G
Y
-
E
Y
L
F
C
I
C
------
N
N
S
---------------------------
E
---------
W
M
E
T
V
D
Q
Y
A
K
A
V
--------------------------------------------
T
V
N
G
E
K
G
V
V
L
R
P
D
--
Q
M
K
W
T
A
P
L
-------
K
P
F
----
S
H
P
V
D
A
V
---
I
Y
E
T
H
L
R
D
F
S
-
I
-
H
E
N
-
S
G
M
I
N
K
G
K
Y
--------
L
A
L
T
--------
E
-----------
T
-------
D
----
T
Q
TANGSSSG---
L
A
Y
V
K
E
L
G
V
T
H
V
E
L
L
P
V
N
D
F
A
G
V
D
E
--------------------------------------------------------------------------------------------------
E
K
P
L
D
-----------------
A
Y
N
W
G
Y
N
P
L
H
F
F
A
P
E
G
S
Y
A
S
N
P
H
-----------------------------------------------------
D
P
Q
T
R
K
T
E
L
K
Q
-
M
I
N
T
L
H
-
Q
H
-
G
L
R
-
V
I
L
-
D
V
V
F
N
H
V
YK
R
------
E
--
N
------
S
------
P
F
------
E
K
------------
T
-
V
P
G
Y
F
F
R
H
-
D
E
C
-
G
K
-
P
S
N
G
T
G
-
V
G
N
D
I
A
S
E
R
R
M
-
A
R
K
F
I
A
D
C
V
V
Y
W
L
E
E
Y
N
V
D
G
F
R
F
D
L
L
-
G
I
L
D
----
I
D
-----
T
V
L
-------------------------------
Y
M
K
E
K
A
T
K
--
A
K
P
G
I
L
L
F
G
E
G
W
D
L
--
A
T
P
L
P
H
E
Q
K
A
A
L
A
N
A
---
P
R
M
P
G
---
I
G
F
F
N
D
M
F
----
R
D
A
V
K
G
N
T
F
H
-
L
-----------------------
K
-----
A
T
G
F
A
L
G
N
G
--------------------
E
S
A
Q
-----------
A
V
----
M
---------------
H
-------------------------
G
I
A
GSS
G
------------------------
W
K
---------------
A
L
A
----
P
--
I
------
V
-----
P
E
P
S
Q
S
I
N
Y
V
E
S
H
D
N
H
T
F
W
D
---
K
M
S
F
A
---
L
P
Q
E
-------------------------
N
--------------------------
D
S
--
R
K
R
S
R
Q
R
--
L
A
-
V
A
I
I
L
L
A
----
Q
G
V
P
F
I
H
S
G
Q
E
F
F
R
T
K
Q
-------------------------------------------
G
V
E
N
S
-
Y
Q
S
S
D
-----
S
I
N
Q
L
D
W
D
R
R
E
T
F
---------------------------------
K
E
D
V
H
Y
I
R
R
-
L
I
S
L
R
K
A
H
P
A
F
R
L
R
S
A
A
D
I
Q
-------
R
H
L
E
C
-
L
T
L
--------------
K
E
H
L
I
A
Y
-------
R
L
Y
D
L
------------
D
---------
E
VDEW
K
D
I
I
V
I
H
H
A
S
P
D
S
V
-
E
W
---
R
L
P
N
D
I
P
----
Y
R
L
L
C
-
D
P
S
G
F
-
Q
E
D
P
T
E
-
I
K
K
T
---
V
A
V
-
N
G
I
G
T
V
I
L
Y
L
A
S
----------------------------------------------------------------------------------------------------
28
HHSearch
62.86
30%
-52
* C1 *
2E8Y
3
PULA_BACSU
A:
[87-712]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
G
A
V
I
R
T
A
A
F
-----
D
D
E
F
Y
Y
D
---
G
-
E
---
L
G
A
V
Y
T
A
-
D
--
H
T
V
F
K
V
W
A
P
A
A
T
S
A
A
V
K
L
S
H
P
N
K
S
---
G
R
T
F
Q
-
M
T
R
L
-
E
K
G
V
Y
A
V
T
V
T
G
-----------
D
L
H
G
Y
-
E
Y
L
F
C
I
C
------
N
N
S
---------------------------
E
---------
W
M
E
T
V
D
Q
Y
A
K
A
V
T
V
N
G
E
--------------------------------------------
K
G
V
V
L
R
P
D
--
Q
M
K
---
W
T
A
P
--
L
--
K
P
F
----
S
H
P
V
D
A
V
---
I
Y
E
T
H
L
R
D
F
S
-
I
-
H
E
N
-
S
G
M
I
N
K
G
K
Y
LALTETDT
Q
T
A
N
--------
G
-----------
S
-------
S
----
S
G
-----------
L
A
Y
V
K
E
L
G
V
T
H
V
E
L
L
P
V
N
D
F
A
G
V
D
E
E
-
K
P
-------------------------------------------------------------------------------------------------
L
D
-----------------
A
Y
N
W
G
Y
N
P
L
H
F
F
A
P
E
G
S
Y
A
S
N
P
H
-----------------------------------------------------
D
P
Q
T
R
K
T
E
L
K
Q
-
M
I
N
T
L
H
-
Q
H
-
G
L
R
-
V
I
L
-
D
V
V
F
N
H
V
--
Y
------
K
--
R
EN----
S
------
P
F
------
E
K
------------
T
-
V
P
G
Y
F
F
R
H
-
D
E
C
-
G
K
-
P
S
N
G
T
G
V
G
N
D
-
I
A
S
E
R
R
M
-
A
R
K
F
I
A
D
C
V
V
Y
W
L
E
E
Y
N
V
D
G
F
R
F
D
L
L
-
G
I
L
D
----
I
D
-----
T
V
L
-------------------------------
Y
M
K
E
K
A
T
K
--
A
K
P
G
I
L
L
F
G
E
G
W
D
L
A
T
P
L
-
P
H
-
E
Q
K
A
A
L
A
N
A
---
P
R
M
P
G
---
I
G
F
F
N
D
M
F
----
R
D
A
V
K
G
N
T
F
H
-
L
-----------------------
K
-----
A
T
G
F
A
L
G
N
G
--------------------
E
S
A
Q
-----------
A
V
----
M
---------------
H
-------------------------
G
I
----
A
------------------------
G
S
---------------
S
G
W
KALA
P
--
I
------
V
-----
P
E
P
S
Q
S
I
N
Y
V
E
S
H
D
N
H
T
F
W
D
---
K
M
S
F
A
L
P
Q
E
----------------------------
N
--------------------------
D
S
--
R
K
R
S
R
Q
R
--
L
A
-
V
A
I
I
L
L
A
----
Q
G
V
P
F
I
H
S
G
Q
E
F
F
R
T
K
Q
G
V
-------------------------------------------
E
N
S
-
Y
Q
S
S
D
-----
S
I
N
Q
L
D
W
D
R
R
E
---------------------------------
T
F
K
E
D
V
H
Y
I
R
R
-
L
I
S
L
R
K
A
H
P
A
F
R
L
R
S
A
A
D
I
Q
-------
R
H
L
E
C
-
L
T
L
--------------
K
E
H
L
I
A
Y
-------
R
L
Y
D
L
------------
D
EVDE-----
W
----
K
D
I
I
V
I
H
H
A
S
P
D
S
V
-
E
W
---
R
L
P
N
----
D
I
P
Y
R
L
L
C
-
D
P
S
G
F
-
Q
E
D
P
-----------
T
E
-
I
K
K
T
V
A
V
N
G
I
G
T
V
I
L
Y
L
A
S
---------------------------------------------------------------------------------------------
8
PsiBlast_PDB
61.54
29%
-52
- C1 -
2E8Z
4
PULA_BACSU
A:
[96-647]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
D
-----
D
E
F
Y
-
Y
D
---
G
-
E
---
L
G
A
V
Y
T
A
-
D
H
T
V
F
K
--
V
W
A
P
A
A
T
S
A
A
V
K
L
S
H
P
N
K
S
G
R
T
F
Q
M
T
R
-
L
----
E
K
G
V
Y
A
V
T
V
T
G
--
D
--
L
-------
H
G
Y
-
E
Y
L
F
C
I
C
------
N
N
S
---------------------------
E
---------
W
M
E
T
V
D
Q
Y
A
K
A
V
--------
T
V
----------------
N
----------------
G
E
----
K
G
V
V
L
R
P
D
--
Q
M
K
W
T
----
A
P
-
L
--
K
P
F
----
S
H
P
V
D
A
V
---
I
Y
E
T
H
L
R
D
F
S
-
I
-
H
E
N
-
S
G
M
I
N
K
G
K
Y
--------
L
A
L
T
ETDTQTAN
G
-----------
S
-------
S
----
S
G
-----------
L
A
Y
V
K
E
L
G
V
T
H
V
E
L
L
P
V
N
D
F
A
G
V
D
E
--------------------------------------------------------------------------------------------------
E
K
P
L
D
-----------------
A
Y
N
W
G
Y
N
P
L
H
F
F
A
P
E
G
S
Y
A
S
N
P
H
-----------------------------------------------------
D
P
Q
T
R
K
T
E
L
K
Q
-
M
I
N
T
L
H
-
Q
H
-
G
L
R
-
V
I
L
-
D
V
V
F
N
H
V
--
Y
------
K
RE
N
------
S
------
P
F
------
E
K
------------
T
-
V
P
G
Y
F
F
R
H
-
D
E
C
-
G
K
-
P
S
N
G
T
G
V
G
N
D
-
I
A
S
E
R
R
M
-
A
R
K
F
I
A
D
C
V
V
Y
W
L
E
E
Y
N
V
D
G
F
R
F
D
L
L
-
G
I
L
D
----
I
D
-----
T
V
L
-------------------------------
Y
M
K
E
K
A
T
K
--
A
K
P
G
I
L
L
F
G
E
G
W
-----
D
L
A
T
P
L
P
H
E
Q
K
A
A
L
---
A
N
A
P
R
MPG
I
G
F
F
N
D
M
F
----
R
D
A
V
K
G
N
T
F
H
-
L
-----------------------
K
-----
A
T
G
F
A
L
G
N
G
--------------------
E
S
A
Q
-----------
A
V
----
M
---------------
H
-------------------------
G
I
----
A
------------------------
G
S
---------------
S
G
-----
W
--
K
------
A
LAPIV
P
E
P
S
Q
S
I
N
Y
V
E
S
H
D
N
H
T
F
W
D
---
K
M
S
F
A
L
---
P
Q
E
-------------------------
N
--------------------------
D
S
--
R
K
R
S
R
Q
R
--
L
A
-
V
A
I
I
L
L
A
----
Q
G
V
P
F
I
H
S
G
Q
E
F
F
R
T
K
Q
-------------------------------------------
G
V
E
N
S
-
Y
Q
S
S
D
-----
S
I
N
Q
L
D
W
------------------
D
R
---------------
R
E
T
F
K
E
D
V
H
Y
I
R
R
-
L
I
S
L
R
K
A
H
P
A
F
R
L
R
S
A
A
D
I
Q
-------
R
H
L
E
C
-
L
T
-------------
L
-
K
E
H
L
I
A
Y
-------
R
L
Y
D
L
------------
D
---------
E
----
V
D
E
W
K
D
I
I
V
I
H
H
A
S
-
P
D
---
S
V
E
W
R
L
P
N
D
I
P
Y
R
L
L
C
-
D
P
S
G
F
-
Q
E
D
P
T
E
-
I
K
K
T
---
V
A
V
-
N
G
I
G
T
V
I
L
Y
L
A
S
----------------------------------------------------------------------------------------------------
9
PsiBlast_PDB
61.51
29%
-54
- C1 -
2E9B
6
PULA_BACSU
A:
[96-647]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
D
-----
D
E
F
Y
-
Y
D
---
G
-
E
---
L
G
A
V
Y
T
A
-
D
H
T
V
F
K
--
V
W
A
P
A
A
T
S
A
A
V
K
L
S
H
P
N
K
S
G
R
T
F
Q
M
T
R
-
L
----
E
K
G
V
Y
A
V
T
V
T
G
--
D
--
L
-------
H
G
Y
-
E
Y
L
F
C
I
C
------
N
N
S
---------------------------
E
---------
W
M
E
T
V
D
Q
Y
A
K
A
V
--------
T
V
----------------
N
----------------
G
E
----
K
G
V
V
L
R
P
D
--
Q
M
K
W
T
----
A
P
-
L
--
K
P
F
----
S
H
P
V
D
A
V
---
I
Y
E
T
H
L
R
D
F
S
-
I
-
H
E
N
-
S
G
M
I
N
K
G
K
Y
--------
L
A
L
T
ETDTQTAN
G
-----------
S
-------
S
----
S
G
-----------
L
A
Y
V
K
E
L
G
V
T
H
V
E
L
L
P
V
N
D
F
A
G
V
D
E
--------------------------------------------------------------------------------------------------
E
K
P
L
D
-----------------
A
Y
N
W
G
Y
N
P
L
H
F
F
A
P
E
G
S
Y
A
S
N
P
H
-----------------------------------------------------
D
P
Q
T
R
K
T
E
L
K
Q
-
M
I
N
T
L
H
-
Q
H
-
G
L
R
-
V
I
L
-
D
V
V
F
N
H
V
--
Y
------
K
RE
N
------
S
------
P
F
------
E
K
------------
T
-
V
P
G
Y
F
F
R
H
-
D
E
C
-
G
K
-
P
S
N
G
T
G
V
G
N
D
-
I
A
S
E
R
R
M
-
A
R
K
F
I
A
D
C
V
V
Y
W
L
E
E
Y
N
V
D
G
F
R
F
D
L
L
-
G
I
L
D
----
I
D
-----
T
V
L
-------------------------------
Y
M
K
E
K
A
T
K
--
A
K
P
G
I
L
L
F
G
E
G
W
-----
D
L
A
T
P
L
P
H
E
Q
K
A
A
L
---
A
N
A
P
R
MPG
I
G
F
F
N
D
M
F
----
R
D
A
V
K
G
N
T
F
H
-
L
-----------------------
K
-----
A
T
G
F
A
L
G
N
G
--------------------
E
S
A
Q
-----------
A
V
----
M
---------------
H
-------------------------
G
I
----
A
------------------------
G
S
---------------
S
G
-----
W
--
K
------
A
LAPIV
P
E
P
S
Q
S
I
N
Y
V
E
S
H
D
N
H
T
F
W
D
---
K
M
S
F
A
L
---
P
Q
E
-------------------------
N
--------------------------
D
S
--
R
K
R
S
R
Q
R
--
L
A
-
V
A
I
I
L
L
A
----
Q
G
V
P
F
I
H
S
G
Q
E
F
F
R
T
K
Q
-------------------------------------------
G
V
E
N
S
-
Y
Q
S
S
D
-----
S
I
N
Q
L
D
W
------------------
D
R
---------------
R
E
T
F
K
E
D
V
H
Y
I
R
R
-
L
I
S
L
R
K
A
H
P
A
F
R
L
R
S
A
A
D
I
Q
-------
R
H
L
E
C
-
L
T
-------------
L
-
K
E
H
L
I
A
Y
-------
R
L
Y
D
L
------------
D
---------
E
----
V
D
E
W
K
D
I
I
V
I
H
H
A
S
-
P
D
---
S
V
E
W
R
L
P
N
D
I
P
Y
R
L
L
C
-
D
P
S
G
F
-
Q
E
D
P
T
E
-
I
K
K
T
---
V
A
V
-
N
G
I
G
T
V
I
L
Y
L
A
S
----------------------------------------------------------------------------------------------------
7
PsiBlast_PDB
60.99
29%
-51
- C1 -
2E8Y
3
PULA_BACSU
A:
[96-647]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
D
-----
D
E
F
Y
-
Y
D
---
G
-
E
---
L
G
A
V
Y
T
A
-
D
H
T
V
F
K
--
V
W
A
P
A
A
T
S
A
A
V
K
L
S
H
P
N
K
S
G
R
T
F
Q
M
T
R
-
L
----
E
K
G
V
Y
A
V
T
V
T
G
--
D
--
L
-------
H
G
Y
-
E
Y
L
F
C
I
C
------
N
N
S
---------------------------
E
---------
W
M
E
T
V
D
Q
Y
A
K
A
V
--------
T
V
----------------
N
----------------
G
E
----
K
G
V
V
L
R
P
D
--
Q
M
K
W
T
----
A
P
-
L
--
K
P
F
----
S
H
P
V
D
A
V
---
I
Y
E
T
H
L
R
D
F
S
-
I
-
H
E
N
-
S
G
M
I
N
K
G
K
Y
--------
L
A
L
T
ETDTQTAN
G
-----------
S
-------
S
----
S
G
-----------
L
A
Y
V
K
E
L
G
V
T
H
V
E
L
L
P
V
N
D
F
A
G
V
D
E
--------------------------------------------------------------------------------------------------
E
K
P
L
D
-----------------
A
Y
N
W
G
Y
N
P
L
H
F
F
A
P
E
G
S
Y
A
S
N
P
H
-----------------------------------------------------
D
P
Q
T
R
K
T
E
L
K
Q
-
M
I
N
T
L
H
-
Q
H
-
G
L
R
-
V
I
L
-
D
V
V
F
N
H
V
--
Y
------
K
RE
N
------
S
------
P
F
------
E
K
------------
T
-
V
P
G
Y
F
F
R
H
-
D
E
C
-
G
K
-
P
S
N
G
T
G
V
G
N
D
-
I
A
S
E
R
R
M
-
A
R
K
F
I
A
D
C
V
V
Y
W
L
E
E
Y
N
V
D
G
F
R
F
D
L
L
-
G
I
L
D
----
I
D
-----
T
V
L
-------------------------------
Y
M
K
E
K
A
T
K
--
A
K
P
G
I
L
L
F
G
E
G
W
-----
D
L
A
T
P
L
P
H
E
Q
K
A
A
L
---
A
N
A
P
R
MPG
I
G
F
F
N
D
M
F
----
R
D
A
V
K
G
N
T
F
H
-
L
-----------------------
K
-----
A
T
G
F
A
L
G
N
G
--------------------
E
S
A
Q
-----------
A
V
----
M
---------------
H
-------------------------
G
I
----
A
------------------------
G
S
---------------
S
G
-----
W
--
K
------
A
LAPIV
P
E
P
S
Q
S
I
N
Y
V
E
S
H
D
N
H
T
F
W
D
---
K
M
S
F
A
L
---
P
Q
E
-------------------------
N
--------------------------
D
S
--
R
K
R
S
R
Q
R
--
L
A
-
V
A
I
I
L
L
A
----
Q
G
V
P
F
I
H
S
G
Q
E
F
F
R
T
K
Q
-------------------------------------------
G
V
E
N
S
-
Y
Q
S
S
D
-----
S
I
N
Q
L
D
W
------------------
D
R
---------------
R
E
T
F
K
E
D
V
H
Y
I
R
R
-
L
I
S
L
R
K
A
H
P
A
F
R
L
R
S
A
A
D
I
Q
-------
R
H
L
E
C
-
L
T
-------------
L
-
K
E
H
L
I
A
Y
-------
R
L
Y
D
L
------------
D
---------
E
----
V
D
E
W
K
D
I
I
V
I
H
H
A
S
-
P
D
---
S
V
E
W
R
L
P
N
D
I
P
Y
R
L
L
C
-
D
P
S
G
F
-
Q
E
D
P
T
E
-
I
K
K
T
---
V
A
V
-
N
G
I
G
T
V
I
L
Y
L
A
S
----------------------------------------------------------------------------------------------------
54
Fugue
59.75
26%
-29
- C1 -
2YOC
8
PULA_KLEPN
A:
[20-1070]
----------------------------
D
V
V
V
R
L
P
D
V
A
V
P
G
E
A
V
T
A
V
E
N
Q
A
V
I
H
L
V
D
I
A
G
I
T
S
S
S
A
A
D
Y
S
S
--------------------------------------
K
N
L
Y
L
W
N
-----------------------
N
E
T
C
D
A
L
S
A
P
V
A
D
-----------------------------------
W
N
D
-----
V
S
T
T
P
S
G
------------
S
D
K
Y
G
P
Y
W
V
I
P
L
N
-
K
E
S
G
C
I
N
V
I
V
R
D
G
T
D
K
L
I
D
S
D
L
R
V
A
-------------------
F
G
D
F
T
D
R
T
V
S
V
I
A
G
-------
N
S
A
V
Y
D
S
R
A
D
A
F
R
A
A
F
G
V
A
L
-----
A
E
A
H
W
V
D
K
-
N
T
L
L
W
P
G
G
Q
D
K
-------------
P
I
V
R
L
Y
Y
S
H
S
S
K
V
A
A
D
G
E
G
K
F
T
D
R
Y
-
L
----
K
L
T
P
T
T
V
S
Q
Q
V
S
M
R
F
P
H
L
-------------------
S
S
Y
--
A
A
F
K
L
P
D
N
A
N
V
D
E
L
----
L
Q
-------------------------
G
----------
E
T
V
A
I
A
A
----
A
---
E
D
G
----
I
L
-
I
S
A
----
T
Q
V
Q
T
A
G
V
L
D
D
A
-----
Y
A
E
A
A
E
A
---
L
-
S
---
Y
G
A
Q
L
A
D
-
G
G
--
V
T
F
R
V
W
A
P
T
A
Q
Q
V
D
V
V
V
Y
S
A
D
K
--
K
V
I
G
S
H
P
M
T
R
D
S
-
A
S
G
A
W
S
W
Q
G
G
S
--
D
--
L
-
K
G
A
-
F
Y
R
Y
A
M
T
V
Y
H
P
Q
S
------
R
K
V
---------------------------
E
---------
Q
Y
E
V
T
D
P
Y
A
H
S
L
S
T
N
S
E
Y
--
S
Q
----------------
V
----------------
V
D
L
--------
N
D
S
--
A
L
K
P
D
G
W
D
N
L
T
M
P
--
H
A
Q
----
K
T
K
A
D
L
A
K
M
T
I
H
E
S
H
I
R
D
L
S
-
A
W
D
Q
T
-
V
P
A
E
L
R
G
K
Y
--------
L
A
L
T
--------
A
-----------
G
-------
D
S
N
M
V
Q
H
-----------
L
K
T
L
S
A
S
G
V
T
H
V
E
L
L
P
V
F
D
L
A
T
V
N
E
F
-
S
D
-
K
V
----------------------------------------------------
A
DIQQP
F
S
R
L
C
E
V
N
SAVKSSEFAGYCDSGST
V
E
E
V
L
N
Q
L
K
Q
S
D
S
QDNP
Q
V
Q
A
L
N
T
L
V
A
Q
T
D
S
Y
N
W
G
Y
D
P
F
H
Y
T
V
P
E
G
S
Y
A
T
D
P
E
-----------------------------------------------------
G
-
T
T
R
I
K
E
F
R
T
M
I
--
Q
A
I
-
K
Q
-
D
L
G
M
N
V
I
M
D
V
V
Y
N
H
T
--
N
AAGPTD
R
--
T
------
S
------
V
L
------
D
K
------------
I
-
V
P
W
Y
Y
Q
R
L
-
N
E
T
-
T
G
-
S
V
E
S
A
T
-
C
C
S
-
D
S
A
P
E
H
R
M
F
A
K
L
I
A
D
S
L
A
V
W
T
T
D
Y
K
I
D
G
F
R
F
D
L
-M
G
Y
H
P
----
K
A
-----
Q
I
L
-------------------------------
S
A
W
E
R
I
K
A
--
L
N
P
D
I
Y
F
F
G
E
G
W
D
S
N
Q
S
D
R
---
F
E
I
A
S
Q
I
N
L
---
K
G
T
G
----
I
G
T
F
S
D
R
L
----
R
D
S
V
R
G
G
G
P
F
-
D
-----------------------
S
-----
G
D
A
L
R
Q
N
Q
G
IGSGAGVLPNELASLS
D
D
Q
V
R
H
L
A
-----------
D
L
----
T
---------------
R
L
G
M
A
GNLAD
F
V
M
I
D
KDG
A
A
K
K
GSEI
D
Y
----
N
------------------------
G
A
---------------
P
G
G
----
Y
---------
A
-----
A
D
P
T
E
V
V
N
Y
V
S
K
H
D
N
Q
T
L
W
D
M
--
I
S
Y
K
---------------------------------
A
--------------------------
S
Q
--
E
A
D
L
A
T
R
--
V
R
M
Q
A
V
S
L
A
T
V
M
L
G
Q
G
I
A
F
D
Q
Q
G
S
E
L
L
R
S
K
S
-------------------------------------------
F
T
R
D
S
-
Y
D
S
G
D
-----
W
F
N
R
V
D
Y
S
L
Q
D
N
N
--------------------------------------
Y
N
V
G
M
P
---
R
I
S
D
D
G
----
S
N
Y
E
V
I
-------
T
R
V
K
E
M
V
A
T
P
G
E
----
A
E
L
K
-
Q
M
T
---
A
F
Y
-------
Q
E
L
T
E
------------
L
---------
R
----
K
S
S
P
L
F
T
L
G
D
G
S
A
V
M
K
R
---
V
D
F
R
N
T
G
S
D
Q
Q
A
G
L
L
V
M
T
V
D
D
G
M
K
A
G
A
S
L
-
D
S
R
-----------------
L
D
G
L
V
V
A
I
N
-
A
A
P
E
S
--------------------
R
T
L
N
E
F
A
G
E
T
L
Q
L
S
A
I
Q
Q
T
A
G
E
N
S
L
A
N
G
V
Q
I
A
A
D
G
T
V
T
L
P
A
W
S
V
A
V
L
E
L
P
Q
G
E
A
Q
G
A
G
L
P
V
S
S
-----
10
PsiBlast_PDB
59.20
29%
-44
- C1 -
3WDH
1
?
A:
[101-685]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
D
L
Y
A
Y
D
---
G
-
N
D--
L
G
A
--
T
Y
-
D
P
E
K
T
T
F
K
V
W
A
P
T
A
T
D
V
L
L
K
L
I
H
P
T
T
K
E
E
--
T
T
Y
V
-
M
T
R
E
-
K
K
G
L
W
T
Y
T
V
Y
D
--
D
--
V
-
E
R
F
-
L
Y
T
Y
M
-
T
Y
V
N
F
I
W
------
R
-----------------------------------------
E
A
V
D
P
Y
A
K
S
V
S
V
--
N
G
--
T
Y
----------------
G
----------------
V
V
V
D
L
A
K
T
N
I
P
K
P
S
--------------
M
--
S
L
F
----
I
S
M
T
D
A
I
---
I
Y
E
M
H
I
R
D
F
T
-
I
-
H
H
E
-
S
G
V
R
Q
K
G
K
Y
--------
V
-----------
G
-----------
L
-------
T
----
E
R
GTTGPNGTLTG
L
S
Y
I
K
Q
L
G
V
T
H
V
Q
L
M
P
V
Q
D
F
E
G
V
D
E
L
-
Q
P
-
L
K
----------------------------------------------------
M
-------------------------------------------------------------
Y
N
W
G
Y
N
T
V
H
Y
N
A
P
E
G
S
Y
A
T
D
P
D
-----------------------------------------------------
D
P
Y
A
R
I
I
E
L
K
R
-
A
I
R
A
F
Q
-
Q
E
-
G
I
R
-
V
I
L
-
D
V
V
Y
N
H
V
YV
R
------
E
--
T
------
S
------
S
F
------
E
H
------------
L
-
V
P
G
Y
Y
F
R
Y
-
E
R
N
-
G
Y
-
P
S
N
G
T
G
V
G
N
D
-
L
A
S
E
R
K
M
-
V
K
K
F
I
I
D
S
V
T
Y
W
L
K
E
Y
G
V
D
G
F
R
F
D
L
M
-
G
I
L
D
----
I
D
-----
T
M
N
-------------------------------
D
V
R
R
A
I
D
E
--
I
D
P
T
V
I
I
L
G
E
G
W
-----
D
L
A
T
P
L
P
S
E
K
K
T
T
I
ANA
K
H
T
P
R
---
I
A
Y
F
N
D
R
F
----
R
D
Y
V
K
G
S
T
F
D
-
I
-----------------------
H
-----
E
R
G
F
A
L
G
D
C
--------------------
S
Y
K
E
-----------
A
V
----
I
---------------
G
-------------------------
A
I
----
R
------------------------
G
S
---------------
I
H
L
----
F
--
F
-------------
S
P
R
Q
S
V
N
Y
V
E
C
H
D
N
H
T
L
W
D
---
K
M
A
V
A
-----
N
A
-------------------------
H
--------------------------
E
S
--
E
Y
I
R
R
K
R
Q
K
L
A
-
T
A
I
V
L
L
S
----
Q
G
I
P
F
L
H
S
G
Q
E
F
Y
R
T
K
K
-------------------------------------------
G
V
E
N
S
-
Y
N
S
P
D
-----
E
V
N
Q
V
D
W
-----
N
------------
E
K
---------------
S
R
W
E
E
D
V
R
E
-
I
M
K
-
L
I
E
L
R
K
K
H
G
A
F
R
F
L
T
A
D
Q
V
R
-------
R
H
M
K
F
-------------
Y
D
-
T
-
H
P
S
V
I
A
Y
-------
Q
L
V
D
V
------------
G
VYGPW----
K
----
Q
I
V
V
V
Y
H
N
E
E
K
K
A
M
-
L
P
---
L
A
D
G
K
W
K
V
M
F
S
S
E
L
G
N
-
V
C
E
Q
F
-
I
E
I
N
G
I
-
G
A
W
V
---
L
I
Q
-
C
---------------------------------------------------------------------------------------------------------------
31
HHSearch
58.79
22%
-40
- C1 -
1BF2
1
ISOA_PSEAY
A:
[5-749]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
-
S
---
L
G
A
S
Y
D
A
-
Q
Q
A
N
I
T
F
R
V
Y
S
S
Q
A
T
R
I
V
L
Y
L
Y
S
A
G
Y
G
V
Q
E
S
A
T
Y
T
-
L
S
P
A
-
G
S
G
V
W
A
V
T
V
P
V
--
S
--
S
I
K
A
A
G
I
T
G
A
V
-
Y
Y
G
Y
R
A
W
------
G
P
N
WPYASNWGKGSQAGFVSDVDANGDRFN
P
---------
N
K
L
L
L
D
P
Y
A
Q
E
V
S
Q
D
P
L
N
--
P
S
NQNGNVFASGASYRTT
D
----------------
S
G
I
Y
A
P
K
G
V
V
L
V
P
S
--
T
-----
Q
S
T
G
T
-
K
--
P
T
-----
R
A
Q
K
D
D
V
---
I
Y
E
V
H
V
R
G
F
T
-
E
-
Q
D
T
-
S
I
P
A
--
Q
Y
R
--------
G
T
Y
Y
--------
G
-----------
A
-------
G
----
L
K
-----------
A
S
Y
L
A
S
L
G
V
T
A
V
E
F
L
P
V
Q
E
T
Q
N
D
A
N
D
-
V
V
---------------------------------------------------------------------------------------------
P
N
S
D
A
N
-----------------
Q
N
Y
W
G
Y
M
T
E
N
Y
F
S
P
D
R
R
Y
A
Y
N
K
A
-----------------------------------------------------
A
G
-
G
P
T
A
E
F
Q
A
-
M
V
Q
A
F
H
-
N
A
-
G
I
K
-
V
Y
M
-
D
V
V
Y
N
H
T
--
A
------
E
--
G
------
G
------
T
W
T-----
S
S
DPT
T
A
T
I
Y
S
WRG
L
-
D
N
A
T
Y
Y
E
L
T
S
G
N
-
Q
Y
-
F
Y
D
N
T
G
I
G
A
N
-
F
N
T
Y
N
T
V
-
A
Q
N
L
I
V
D
S
L
A
Y
W
A
N
T
M
G
V
D
G
F
R
F
D
L
A
-
S
V
L
G
----
N
S
-----
C
L
N
GAYTASAPNCPNGG
Y
N
F
D
AADSNV
A
I
N
R
I
L
R
E
F
T
V
R
P
A
A
--
G
G
S
G
L
D
L
F
A
E
P
W
A
I
G
G
N
S
--
Y
Q
L
G
G
F
----------
P
Q
G
---
W
S
E
W
N
G
L
F
----
R
D
S
L
R
Q
A
Q
N
E
-
L
-----------------------
G
S----
M
T
I
Y
V
T
Q
D
-----------------------
A
N
-----------
D
F
----
S
------------------------------------------------------------------------
G
S
---------------
S
N
L
----
F
QS
S
------
G
-----
R
S
P
W
N
S
I
N
F
I
D
V
H
D
G
M
T
L
K
D
---
V
Y
S
C
N
G
A
N
N
S
Q
A
WPYGPSDGGTSTNYSWDQGMSAGTG
A
--------------------------
A
V
--
D
Q
R
R
A
A
R
--
T
G
-
M
A
F
E
M
L
S
----
A
G
T
P
L
M
Q
G
G
D
E
Y
L
R
T
L
Q
C
N
-------------------------------------------
N
N
A
-
Y
N
L
D
S
-----
S
A
N
W
L
T
Y
S
W
T
T
---------------------------------
D
Q
S
N
F
Y
T
F
A
Q
R
-
L
I
A
F
R
K
A
H
P
A
L
R
P
S
S
W
Y
S
G
S
--------
Q
L
T
W
-
Y
Q
P
S
G
A
VAD
S
N
Y
W
N
N
T
-
S
N
Y
A
I
A
Y
-------
A
I
N
G
P
SLG---------
D
---------
S
----
N
S
I
Y
V
A
Y
N
G
W
S
S
S
V
-
T
F
---
T
L
P
A
P
P
S
-
G
T
Q
W
Y
R
V
T
-
D
T
C
D
W
-
N
D
G
A
S
T
F
V
A
P
G
SET
L
I
G
G
A
G
T
T
Y
G
Q
C
G
Q
S
L
L
L
L
I
S
K
----------------------------------------------------------------------------------------------
32
HHSearch
56.37
23%
-46
- C1 -
2VR5
5
?
A:
[10-716]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
-----
P
L
R
P
G
D
P
---
Y
-
P
---
L
G
S
N
W
I
E
D
D
D
-
G
V
N
F
S
L
F
S
E
N
A
E
K
V
E
L
L
L
Y
S
L
T
N
Q
K
Y
P
K
E
I
I
E
-
V
K
N
K
-
T
G
D
I
W
H
V
F
V
P
G
-----------
L
R
P
G
Q
-
L
Y
A
Y
R
V
Y
------
G
P
Y
---------------------------
K
PELG
L
R
F
N
P
N
K
V
L
I
D
P
Y
A
K
A
I
N
G
S
V
I
W
--
N
D
AVF-------------
G
YKIGDQNQDLTYDERD
S
G
E
Y
V
P
K
S
V
V
I
N
P
---
Y
F
E
---
W
D
D
E
D
-
F
IK
G
K
K
----
V
P
L
K
D
T
V
---
I
Y
E
V
H
V
K
G
F
T
-
K
-
L
R
L
-
D
L
P
--
E
N
I
R
--------
G
T
Y
E
--------
G
-----------
L
-------
A
S
E
--
Q
M
-----------
I
S
Y
L
K
D
L
G
I
T
T
V
E
L
M
P
V
F
H
F
I
D
--
Q
R
-
F
L
----------------------------------------------------------------------------------------------
T
D
K
G
L
-----------------
T
N
Y
W
G
Y
D
P
I
N
F
F
S
P
E
C
R
Y
S
S
T
G
C
-----------------------------------------------------
L
G
-
G
Q
V
L
S
F
K
K
-
M
V
N
E
L
H
-
N
A
-
G
I
E
-
V
I
I
-
D
V
V
Y
N
H
T
--
A
------
E
--
G
------
N
------
H
L
G
P
T
L
S
F
R
G
------------
I
D
N
T
A
Y
Y
M
L
Q
-
P
D
N
-
K
R
Y
Y
L
D
F
T
G
T
G
N
T
-
L
N
L
S
H
P
R
-
V
I
Q
M
V
L
D
S
L
R
Y
W
V
T
E
M
H
V
D
G
F
R
F
D
L
A
-
A
A
L
A
----
R
E
LYSVN
M
L
N
-------------------------------
T
F
F
I
A
L
Q
Q
D
P
I
L
S
Q
V
K
L
I
A
E
P
W
D
V
G
Q
G
G
--
Y
Q
V
G
N
F
P
Y
----------
Q
---
W
A
E
W
N
G
K
Y
----
R
D
S
I
R
R
F
W
R
--------------------------------------
G
E
A
--------------------
L
P
Y
S
-----------
E
I
----
A
---------------
N
-------------------------
R
L
----
L
------------------------
G
S
---------------
P
D
I
----
Y
--
L
GN----
N
-----
K
T
P
F
A
S
I
N
Y
V
T
S
H
D
G
F
T
L
E
D
---
L
V
S
Y
N
Q
K
H
N
E
A
N
-------------------------
G
FNNQDGMNENYSWNCGAEGPTND
Q
N
V
V
I
--
C
R
E
K
Q
K
R
--
N
F
-
M
I
T
L
L
V
S
----
Q
G
T
P
M
I
L
G
G
D
E
L
S
R
T
Q
R
G
N
-------------------------------------------
N
N
A
-
F
C
Q
D
N
-----
E
I
T
W
F
D
W
N
L
D
E
---------------------------------
R
K
S
K
F
L
E
F
V
K
K
-
M
I
Q
F
Y
R
A
H
P
A
F
R
R
E
R
Y
F
Q
G
K
KLFGMPL
K
D
V
T
F
-
Y
T
L
E
G
R
EVD
E
K
T
W
S
-
S
-
P
T
Q
L
V
I
F
-------
V
L
E
G
S
VMDEINMYG
E
R
I
A
---------
D
----
D
S
F
L
I
I
L
N
A
N
P
N
N
V
-
K
V
---
K
F
P
K
-----
G
K
W
E
L
V
I
-
S
S
Y
L
R
-
E
I
K
P
E
----
E
R
---
I
I
E
-
G
E
K
E
L
E
I
E
G
R
T
A
L
V
Y
R
R
I
E
L
--------------------------------------------------------------------------------------------
50
Fugue
55.64
21%
-32
- C1 -
2FHF
7
PULA_ENTAE
A:
[32-1083]
-------------------------------------------------------------------------------------------------------------------------------------------
D
V
V
V
R
L
P
D
V
A
V
P
G
E
A
V
Q
A
S
A
R
Q
A
V
I
H
L
V
D
I
A
G
I
T
S
S
T
P
A
D
Y
A
T
K
N
L
Y
L
W
N
N
ETCDA
L
S
A
P
V
A
D
W
N
D
V
--
S
T
T
P
T
G
S
D
K
Y
G
P
Y
W
V
I
P
L
T
K
-
E
S
G
C
I
N
V
I
V
R
D
G
T
N
K
L
I
D
S
D
L
R
V
S
F
S
D
F
T
D
R
T
V
S
V
I
A
G
N
S
-------------------------
A
V
Y
D
S
R
A
D
A
F
R
A
A
F
-
G
V
A
L
-----
A
D
A
H
W
V
D
K
-
T
T
L
L
---------------------------------
W
P
G
G
E
N
K
P
I
V
R
L
-
Y
Y
S
H
S
S
K
V
A
A
D
S
N
G
E
F
S
-
D
K
Y
V
K
L
T
----
P
T
T
V
N
Q
Q
V
S
M
R
F
P
H
L
A
S
Y
P
A
F
K
L
P
D
D
V
N
V
D
E
L
----
L
Q
---------------
G
E
T
V
A
I
A
A
E
S
D
----------
G
-------------------------
I
L
----
S
S
A
T
Q
V
Q
T
A
G
V
L
-----
D
D
T
Y
A
A
A
---
A
-
E
A
L
S
Y
G
A
Q
L
T
D
-
S
G
--
V
T
F
R
V
W
A
P
T
A
Q
Q
V
E
L
V
I
Y
S
A
D
K
K
-
V
I
A
S
H
P
M
-
T
R
D
S
-
A
S
G
A
W
S
W
Q
G
G
----------
S
-
D
L
K
G
A
-
F
Y
R
Y
A
M
T
VYHPQS
R
K
V
---------------------------
E
---------
Q
Y
E
V
T
D
P
Y
A
H
S
L
S
T
N
S
E
Y
--
S
Q
----------------
V
----------------
V
D
L
N
D
S
A
L
K
P
E
G
W
D
--
G
L
T
M
P
H
----
A
-
Q
--
K
T
K
----
A
D
L
A
K
M
T
---
I
H
E
S
H
I
R
D
L
S
A
W
-
D
Q
T
-
V
P
A
E
L
R
G
K
Y
--------
L
A
L
T
AQES----
N
-----------
M
-------
V
----
Q
H
-----------
L
K
Q
L
S
A
S
G
V
T
H
I
E
L
L
P
V
F
D
L
A
T
V
N
E
F
-
S
D
-
K
V
----------------------------------------------------
A
-----------------------------------
D
I
--
Q
Q
P
F
-----------------
S
R
L
C
E
V
N
S
A
V
K
S
S
E
F
A
G
Y
C
D
S
G
S
T
V
E
E
V
L
T
Q
L
KQNDSKDNP
Q
V
Q
A
L
N
T
L
V
A
Q
T
DSYNWGYDPFHYTVPEGSYATDP
E
G
T
A
R
I
K
E
F
R
T
-
M
I
Q
A
I
K
-
Q
D
L
G
M
N
-
V
I
M
-
D
V
V
Y
N
H
T
--
N
------
A
--
A
GPTDRT
S
------
V
L
------
D
K
------------
I
-
V
P
W
Y
Y
Q
R
L
-
N
E
T
-
T
G
-
S
V
E
S
A
T
-
C
C
S
D
S
A
P
E
H
R
M
-
F
A
K
L
I
A
D
S
L
A
V
W
T
T
D
Y
K
I
D
G
F
R
F
D
L
M
-
L
Y
H
P
----
K
A
-----
Q
I
L
-------------------------------
S
A
W
E
R
I
K
A
--
L
N
P
D
I
Y
F
F
G
E
G
W
D
S
---
N
Q
S
D
R
F
E
I
A
S
Q
I
N
L
---
K
G
T
G
----
I
G
T
F
S
D
R
L
----
R
D
A
V
R
G
G
G
P
F
-
D
SGD
A
L
R
Q
N
QGVGSGAGVLPNELT
T
-----
L
S
D
D
Q
A
R
H
L
--------------------
A
D
L
T
-----------
R
L
----
G
M
A
GNLAD
F
V
L
I
D
KDG
A
-------------------------
V
K
----
R
------------------------
G
S
---------------
E
I
D
----
Y
--
N
GAPG
G
Y
A
-----
A
D
P
T
E
V
V
N
Y
V
S
K
H
D
N
Q
T
L
W
D
---
M
I
S
Y
K
A
A
Q
E
--
A
-------------------------
D
--------------------------
L
D
--
T
R
V
R
M
Q
A
--
V
S
-
L
A
T
V
M
L
G
----
Q
G
I
A
F
D
Q
Q
G
S
E
L
L
R
S
K
S
F
T
R
D
S
-----
Y
D
---
S
G
D
W
F
N
R
V
D
Y
S
L
Q
D
----
N
N
----
Y
N
V
G
M
P
R
S
S
-
D
D
G
S
N
-----
Y
D
I
I
A
R
V
K
D
A
V
A
T
------------
P
G
---------------
E
T
E
L
K
Q
M
T
A
F
Y
Q
E
-
L
T
A
L
R
K
S
S
P
L
F
T
L
G
D
G
A
T
V
M
-------
K
R
V
D
F
-
R
N
T
--
G
----
A
D
Q
Q
-
T
-
G
L
L
V
M
T
I
D
DGMQAG
A
S
L
D
S
------------
R
---------
V
----
D
G
I
V
V
A
I
N
A
A
P
E
S
R
-
T
L
---
Q
D
F
A
G
-----
T
S
L
Q
L
S
-
A
I
Q
Q
A
-
A
G
D
R
S
L
-
A
S
G
V
---
Q
V
A
-
A
D
G
S
V
T
L
P
A
W
S
V
A
V
L
E
L
P
Q
G
E
S
Q
G
A
----------------------------------------------------------------------------
G
L
P
V
S
S
K
----
38
HHSearch
55.63
21%
-54
- C1 -
2BHU
3
TREZ_DEIRA
A:
[23-602]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
-
R
---
L
G
A
T
P
L
P
-
G
G
A
G
T
R
F
R
L
W
T
S
T
A
R
T
V
A
V
R
V
N
G
--------
T
E
H
V
-
M
T
S
L
-
G
G
G
I
Y
E
L
E
L
P
V
------------
G
P
G
A
-
R
Y
L
F
V
L
D
------
G
----------------------------------------
V
P
T
P
D
P
Y
A
R
F
L
P
D
G
V
-------------------------------------------
H
G
E
A
E
V
V
D
F
G
--
T
F
D
W
T
D
---
A
D
-
W
--
H
G
-----
I
K
L
A
D
C
V
---
F
Y
E
V
H
V
G
T
F
T
-
P
-
E
--------------------
G
T
Y
R
--------
A
-----------
A
-------
A
----
E
K
-----------
L
P
Y
L
K
E
L
G
V
T
A
I
Q
V
M
P
L
A
A
F
D
----------------------------------------------------------------------------------------------------------
G
-----------------
Q
R
G
W
G
Y
D
G
A
A
F
Y
A
P
Y
A
P
Y
G
R
P
-------------------------------------------------------------
E
D
L
M
A
-
L
V
D
A
A
H
-
R
L
-
G
L
G
-
V
F
L
-
D
V
V
Y
N
H
F
--
G
------
P
--
S
------
G
N-----
Y
L
------
S
S
------------
Y
-
A
P
S
Y
F
T
D
R
--------
F
S
S
A
W
--
G
M
G
-
L
D
Y
A
E
P
H
-
M
R
R
Y
V
T
G
N
A
R
M
W
L
R
D
Y
H
F
D
G
L
R
L
D
A
T
-
P
Y
M
T
DDSE
T
H
-----
I
L
T
-------------------------------
E
L
A
Q
E
I
H
E
--
L
G
G
T
H
L
L
L
A
E
D
H
R
N
L
P
D
L
V
T
---------------
V
N
H
L
---
D
G
I
W
T
D
D
F
H
H
E
T
R
V
T
L
T
G
E
Q
E
----------------------------------
G
Y
Y
A
G
Y
R
--------------------
G
G
A
E
-----------
A
L
----
A
---------------
Y
-------------------------
T
I
----
R
------------------------
R
G
WRYEGQFWAVKGEEH
E
R
G
----
H
--
P
SD----
A
-----
L
E
A
P
N
F
V
Y
C
I
Q
N
H
D
Q
I
G
N
R
P
LGE
R
L
H
Q
S
-----------------------------------------------------------
D
G
--
V
T
L
H
E
Y
R
--
G
A
-
A
A
L
L
L
T
L
----
P
M
T
P
L
L
F
Q
G
Q
E
W
A
A
S
T
P
F
Q
F
F
S
D
H
A
G
E
L
G
Q
A
V
S
E
G
R
K
K
------------------
E
F
-------D
V
P
D
P
Q
A
E
Q
T
F
L
N
S
K
L
N
W
A
E
R
E
G
G
-------------------------------
E
H
A
R
T
L
R
L
Y
R
D
-
L
L
R
L
R
R
E
D
P
V
L
H
N
R
Q
R
E
N
L
T
-------
T
G
---------------------
H
D
G
D
V
L
W
-------
V
R
T
V
T
------------
G
---------
A
----
G
E
R
V
L
L
W
N
L
G
Q
D
T
R
-
A
V
AEV
K
L
P
F
----
T
V
P
R
R
L
L
L
-
H
T
E
---------------------
G
R
E
D
L
T
L
G
A
G
E
A
V
L
V
G
------------------------------------------------------------------------------------------------