@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : bsu02470: (2016-06-04 )
MSVITEQNTYLNFINGEWVKSQSGDMVKVENPADVNDIVGYVQNSTAEDVERAVTAANEAKTAWRKLTGAERGQYLYKTADIMEQRLEEIAACATREMGKTLPEAKGETARGIAILRYYAGEGMRKTGDVIPSTDKDALMFTTRVPLGVVGVISPWNFPVAIPIWKMAPALVYGNTVVIKPATETAVTCAKIIACFEEAGLPAGVINLVTGPGSVVGQGLAEHDGVNAVTFTGSNQVGKIIGQAALARGAKYQLEMGGKNPVIVADDADLEAAAEAVITGAFRSTGQKCTATSRVIVQSGIYERFKEKLLQRTKDITIGDSLKEDVWMGPIASKNQLDNCLSYIEKGKQEGASLLIGGEKLENGKYQNGYYVQPAIFDNVTSEMTIAQEEIFGPVIALIKVDSIEEALNIANDVKFGLSASIFTENIGRMLSFIDEIDAGLVRINAESAGVELQAPFGGMKQSSSHSREQGEAAKDFFTAIKTVFVKP
Atome Classification :
(20 SA)
.........10........20........30........40........50........60--..--.......70........80........90........100....-.-..110-.......120.......130-----.......140.......150.......160.......170.......180.......190.......200.......210.......220.......230.......240...-.-...250........260.......270.......280.......290.......300.......310.......320-.......330.......340.......350.......360.......370.......380.......390.......400.......410.......420.......430.......440.......450.......460.......470.......480......
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
M
S
V
I
TEQN
T
Y
L
N
FIN
G
E
W
VKSQSG
D
M
V
K
VENPA
D
V
N
D
I
V
G
Y
VQNS
T
A
E
D
V
E
R
A
V
T
A
A
N
E
A
---
K
T
--
A
W
R
K
LTGAERG
Q
Y
L
Y
K
T
A
D
I
M
E
Q
R
L
E
E
I
A
A
C
A
T
R
E
M
G
K
TLPEAK-G-ETAR
G
-
I
A
I
L
R
YYAGEGMRKTGDVIP-----STDKD
A
L
M
F
TTRVPL
G
V
V
G
VISPWNF
P
V
A
I
P
I
W
KMA
P
A
L
V
YG
N
T
V
V
IKPAT
E
T
A
V
T
C
A
K
I
I
A
C
F
E
EAGLPAG
V
I
N
LVTG
P
G
S
V
V
G
Q
G
L
A
EHDG
V
N
A
V
T
FTGS
N
Q
V
G
K
I
I
G
Q
A
A
-L-ARG
A
K
-
Y
Q
L
E
MGGKN
P
V
I
V
ADDA
D
L
E
A
A
A
E
A
V
I
T
G
A
F
RSTGQKCTA
T
S
R
V
I
V
Q
S
G
I
Y
E
R
F
K
E
K
L
L
Q
RTKDITIGDSL-KEDVWMGPIAS
K
N
Q
L
D
N
C
L
S
Y
I
E
K
G
K
QEGA
S
L
L
IGGEKLENGKYQN
G
Y
Y
VQ
P
A
I
FDNVTSEM
T
I
A
Q
E
E
IF
G
P
V
I
A
L
I
K
V
D
S
I
E
E
A
L
N
I
A
N
D
V
K
F
G
L
S
A
S
I
F
T
E
N
I
G
R
M
L
S
F
I
D
E
IDA
G
L
V
R
I
NAESA
G
V
E
L
QAPFGGMKQSSSHSREQ
G
E
A
A
K
D
F
F
T
A
I
K
T
VFVKP
126
HHSearch
90.85
38%
-79
* C2 *
4PZ2
6
?
A:
[53-527]
-----------
L
F
I
N
G
S
F
V
D
A
V
S
G
R
T
F
D
T
R
D
P
R
T
-
G
G
V
I
A
S
V
A
E
A
D
K
E
D
V
D
L
A
V
R
A
A
R
A
A
---
F
D
HG
E
W
P
R
M
S
G
S
E
R
G
R
I
M
A
R
L
A
D
L
V
E
E
H
A
G
E
L
A
A
L
E
S
L
D
A
G
K
H
P
A
V
T
R
A
V
-
D
V
G
N
A
-
A
G
S
L
R
Y
F
A
G
A
A
D
K
I
H
G
E
T
L
K
------
M
P
G
Q
F
Q
G
H
T
L
R
E
P
L
G
V
A
G
V
I
I
P
W
N
F
P
S
T
M
F
A
V
K
V
A
P
A
L
A
A
G
C
A
L
V
V
K
P
A
E
Q
T
P
L
S
A
L
Y
L
A
Q
L
A
K
Q
A
G
V
P
D
G
V
I
N
V
V
P
G
F
G
P
T
A
G
A
A
L
A
S
H
M
D
V
D
M
V
S
F
T
G
S
T
E
V
G
R
L
I
M
K
A
S
-
A
E
S
N
L
K
P
-
V
Y
L
E
L
G
G
K
S
P
L
I
V
F
D
D
A
D
L
D
M
A
V
E
L
A
V
G
A
S
F
F
N
K
G
E
A
C
V
A
A
S
R
V
Y
V
Q
E
R
V
Y
D
R
F
E
E
R
L
A
E
R
M
R
S
W
V
V
G
D
P
F
S
D
P
R
A
D
Q
G
P
Q
V
D
K
A
Q
Y
E
R
V
L
S
Y
I
D
H
G
K
R
E
G
A
T
L
L
T
G
G
R
P
C
A
--
P
--
K
G
Y
Y
I
E
P
T
V
F
T
N
V
K
E
D
M
I
I
A
K
E
E
I
F
G
P
V
M
C
L
M
K
F
K
T
V
E
E
A
I
A
R
A
N
D
T
R
Y
G
L
G
A
G
V
V
T
R
D
L
D
V
A
N
R
V
V
R
S
V
R
A
G
V
V
W
V
N
C
-
Y
F
A
M
G
S
D
C
P
F
G
G
R
K
M
S
G
F
G
-
K
D
E
G
M
H
A
L
D
K
Y
L
A
V
K
S
V
V
T
P
-
87
PsiBlast_CBE
90.48
39%
-76
- C2 -
1O9J
2
ALDH1_ELEED
B:
[13-495]
L
T
N
I
K
I
Q
H
T
K
L
-
F
I
N
N
E
W
H
E
S
V
S
G
K
T
F
P
V
F
N
P
A
T
E
E
K
I
C
-
E
V
E
E
A
D
K
E
D
V
D
K
A
V
K
A
A
R
E
A
FQM
G
S
--
P
W
R
T
M
D
A
S
E
R
G
Q
L
I
Y
K
L
A
D
L
I
E
R
D
R
L
L
L
A
T
L
E
S
I
N
A
G
K
V
F
A
S
A
Y
L
M
-
D
L
D
Y
C
-
I
K
A
L
R
Y
C
A
G
W
A
D
K
I
Q
G
R
T
I
P
------
V
D
G
E
F
F
S
Y
T
R
H
E
P
I
G
V
C
G
L
I
F
P
W
N
A
P
M
I
L
L
A
C
K
I
G
P
A
L
C
C
G
N
T
V
I
V
K
P
A
E
Q
T
P
L
T
A
L
H
V
A
S
L
I
K
E
A
G
F
P
P
G
V
V
N
I
V
P
G
Y
G
P
T
A
G
A
A
I
S
S
H
M
D
V
D
K
V
A
F
T
G
S
T
E
V
G
K
M
I
Q
E
A
A
-
A
-
K
S
N
L
K
R
V
T
L
E
L
G
A
K
N
P
C
I
V
F
A
D
A
D
L
D
S
A
V
E
F
A
H
Q
G
V
F
T
N
Q
G
Q
S
C
I
A
A
S
K
L
F
V
E
E
A
I
Y
D
E
F
V
Q
R
S
V
E
R
A
K
K
Y
V
F
G
N
P
L
-
T
P
G
V
N
H
G
P
Q
I
N
K
A
Q
H
N
K
I
M
E
L
I
E
S
G
K
K
E
G
A
K
L
E
C
G
G
G
P
W
G
N
----
K
G
Y
F
I
Q
P
T
V
F
S
N
V
T
D
D
M
R
I
A
K
E
E
I
F
G
P
V
Q
Q
I
M
K
F
K
S
L
D
E
V
I
K
R
A
N
N
T
Y
Y
G
L
V
A
G
V
F
T
K
D
L
D
K
A
V
T
V
S
S
A
L
Q
A
G
T
V
W
V
N
C
Y
L
A
A
-
S
A
Q
S
P
A
G
G
F
K
M
-
S
G
H
G
R
E
M
G
E
Y
G
I
H
E
Y
T
E
V
K
T
V
T
M
K
-
46
PsiBlast_CBE
89.95
40%
-78
- C2 -
4X2Q
1
AL1A2_HUMAN
D:
[27-498]
------------
F
I
N
N
E
W
Q
N
S
E
S
G
R
V
F
P
V
Y
N
P
A
-
T
G
E
Q
V
C
E
V
Q
E
A
D
K
A
D
I
D
K
A
V
Q
A
A
R
L
A
FSL
G
S
--
V
W
R
R
M
D
A
S
E
R
G
R
L
L
D
K
L
A
D
L
V
E
R
D
R
A
V
L
A
T
M
E
S
L
N
G
G
K
P
F
L
Q
A
F
-
Y
-
V
D
L
Q
G
V
I
K
T
F
R
Y
Y
A
G
W
A
D
K
I
H
G
M
T
I
P
------
V
D
G
D
Y
F
T
F
T
R
H
E
P
I
G
V
C
G
Q
I
I
P
W
N
F
P
L
L
M
F
A
W
K
I
A
P
A
L
C
C
G
N
T
V
V
I
K
P
A
E
Q
T
P
L
S
A
L
Y
M
G
A
L
I
K
E
A
G
F
P
P
G
V
I
N
I
L
P
G
Y
G
P
T
A
G
A
A
I
A
S
H
I
G
I
D
K
I
A
F
T
G
S
T
E
V
G
K
L
I
Q
E
A
A
G
R
-
S
N
L
K
R
-
V
T
L
E
L
G
G
K
S
P
N
I
I
F
A
D
A
D
L
D
Y
A
V
E
Q
A
H
Q
G
V
F
F
N
Q
G
Q
C
C
T
A
G
S
R
I
F
V
E
E
S
I
Y
E
E
F
V
R
R
S
V
E
R
A
K
R
R
V
V
G
S
P
F
-
D
P
T
T
E
Q
G
P
Q
I
D
K
K
Q
Y
N
K
I
L
E
L
I
Q
S
G
V
A
E
G
A
K
L
E
C
G
G
K
G
L
G
----
R
K
G
F
F
I
E
P
T
V
F
S
N
V
T
D
D
M
R
I
A
K
E
E
I
F
G
P
V
Q
E
I
L
R
F
K
T
M
D
E
V
I
E
R
A
N
N
S
D
F
G
L
V
A
A
V
F
T
N
D
I
N
K
A
L
T
V
S
S
A
M
Q
A
G
T
V
W
I
N
C
Y
N
A
---------------------
G
E
F
G
L
R
E
Y
S
E
V
K
T
V
T
V
K
-
48
PsiBlast_CBE
89.83
40%
-81
- C2 -
4X2Q
1
AL1A2_HUMAN
B:
[27-498]
------------
F
I
N
N
E
W
Q
N
S
E
S
G
R
V
F
P
V
Y
N
P
A
-
T
G
E
Q
V
C
E
V
Q
E
A
D
K
A
D
I
D
K
A
V
Q
A
A
R
L
A
FSL
G
S
--
V
W
R
R
M
D
A
S
E
R
G
R
L
L
D
K
L
A
D
L
V
E
R
D
R
A
V
L
A
T
M
E
S
L
N
G
G
K
P
F
L
Q
A
F
-
Y
-
V
D
L
Q
G
V
I
K
T
F
R
Y
Y
A
G
W
A
D
K
I
H
G
M
T
I
P
------
V
D
G
D
Y
F
T
F
T
R
H
E
P
I
G
V
C
G
Q
I
I
P
W
N
F
P
L
L
M
F
A
W
K
I
A
P
A
L
C
C
G
N
T
V
V
I
K
P
A
E
Q
T
P
L
S
A
L
Y
M
G
A
L
I
K
E
A
G
F
P
P
G
V
I
N
I
L
P
G
Y
G
P
T
A
G
A
A
I
A
S
H
I
G
I
D
K
I
A
F
T
G
S
T
E
V
G
K
L
I
Q
E
A
A
G
R
-
S
N
L
K
R
-
V
T
L
E
L
G
G
K
S
P
N
I
I
F
A
D
A
D
L
D
Y
A
V
E
Q
A
H
Q
G
V
F
F
N
Q
G
Q
C
C
T
A
G
S
R
I
F
V
E
E
S
I
Y
E
E
F
V
R
R
S
V
E
R
A
K
R
R
V
V
G
S
P
F
-
D
P
T
T
E
Q
G
P
Q
I
D
K
K
Q
Y
N
K
I
L
E
L
I
Q
S
G
V
A
E
G
A
K
L
E
C
G
G
K
G
L
G
----
R
K
G
F
F
I
E
P
T
V
F
S
N
V
T
D
D
M
R
I
A
K
E
E
I
F
G
P
V
Q
E
I
L
R
F
K
T
M
D
E
V
I
E
R
A
N
N
S
D
F
G
L
V
A
A
V
F
T
N
D
I
N
K
A
L
T
V
S
S
A
M
Q
A
G
T
V
W
I
N
C
Y
-----------------------
G
E
F
G
L
R
E
Y
S
E
V
K
T
V
T
V
K
-
86
PsiBlast_CBE
89.67
39%
-76
- C2 -
1O9J
1
ALDH1_ELEED
C:
[13-495]
L
T
N
I
K
I
Q
H
T
K
L
-
F
I
N
N
E
W
H
E
S
V
S
G
K
T
F
P
V
F
N
P
A
T
E
E
K
I
C
-
E
V
E
E
A
D
K
E
D
V
D
K
A
V
K
A
A
R
E
A
FQM
G
S
--
P
W
R
T
M
D
A
S
E
R
G
Q
L
I
Y
K
L
A
D
L
I
E
R
D
R
L
L
L
A
T
L
E
S
I
N
A
G
K
V
F
A
S
A
Y
L
M
-
D
L
D
Y
C
-
I
K
A
L
R
Y
C
A
G
W
A
D
K
I
Q
G
R
T
I
P
------
V
D
G
E
F
F
S
Y
T
R
H
E
P
I
G
V
C
G
L
I
F
P
W
N
A
P
M
I
L
L
A
C
K
I
G
P
A
L
C
C
G
N
T
V
I
V
K
P
A
E
Q
T
P
L
T
A
L
H
V
A
S
L
I
K
E
A
G
F
P
P
G
V
V
N
I
V
P
G
Y
G
P
T
A
G
A
A
I
S
S
H
M
D
V
D
K
V
A
F
T
G
S
T
E
V
G
K
M
I
Q
E
A
A
-
A
-
K
S
N
L
K
R
V
T
L
E
L
G
A
K
N
P
C
I
V
F
A
D
A
D
L
D
S
A
V
E
F
A
H
Q
G
V
F
T
N
Q
G
Q
S
C
I
A
A
S
K
L
F
V
E
E
A
I
Y
D
E
F
V
Q
R
S
V
E
R
A
K
K
Y
V
F
G
N
P
L
-
T
P
G
V
N
H
G
P
Q
I
N
K
A
Q
H
N
K
I
M
E
L
I
E
S
G
K
K
E
G
A
K
L
E
C
G
G
G
P
W
G
N
----
K
G
Y
F
I
Q
P
T
V
F
S
N
V
T
D
D
M
R
I
A
K
E
E
I
F
G
P
V
Q
Q
I
M
K
F
K
S
L
D
E
V
I
K
R
A
N
N
T
Y
Y
G
L
V
A
G
V
F
T
K
D
L
D
K
A
V
T
V
S
S
A
L
Q
A
G
T
V
W
V
N
C
Y
L
A
A
-
S
A
Q
S
P
A
G
G
F
K
M
-
S
G
H
G
R
E
M
G
E
Y
G
I
H
E
Y
T
E
V
K
T
V
T
M
K
-
50
PsiBlast_CBE
89.58
40%
-80
- C2 -
1BI9
2
AL1A2_RAT
C:
[22-493]
------------
F
I
N
N
E
W
Q
N
S
E
S
G
R
V
F
P
V
C
N
P
A
-
T
G
E
Q
V
C
E
V
Q
E
A
D
K
V
D
I
D
K
A
V
Q
A
A
R
L
A
FSL
G
S
--
V
W
R
R
M
D
A
S
E
R
G
R
L
L
D
K
L
A
D
L
V
E
R
D
R
A
T
L
A
T
M
E
S
L
N
G
G
K
P
F
L
Q
A
F
-
Y
-
I
D
L
Q
G
V
I
K
T
L
R
Y
Y
A
G
W
A
D
K
I
H
G
M
T
I
P
------
V
D
G
D
Y
F
T
F
T
R
H
E
P
I
G
V
C
G
Q
I
I
P
W
N
F
P
L
L
M
F
T
W
K
I
A
P
A
L
C
C
G
N
T
V
V
I
K
P
A
E
Q
T
P
L
S
A
L
Y
M
G
A
L
I
K
E
A
G
F
P
P
G
V
V
N
I
L
P
G
Y
G
P
T
A
G
A
A
I
A
S
H
I
G
I
D
K
I
A
F
T
G
S
T
E
V
G
K
L
I
Q
E
A
A
G
R
-
S
N
L
K
R
-
V
T
L
E
L
G
G
K
S
P
N
I
I
F
A
D
A
D
L
D
Y
A
V
E
Q
A
H
Q
G
V
F
F
N
Q
G
Q
C
C
T
A
G
S
R
I
F
V
E
E
S
I
Y
E
E
F
V
K
R
S
V
E
R
A
K
R
R
I
V
G
S
P
F
-
D
P
T
T
E
Q
G
P
Q
I
D
K
K
Q
Y
N
K
I
L
E
L
I
Q
S
G
V
A
E
G
A
K
L
E
C
G
G
K
G
L
G
----
R
K
G
F
F
I
E
P
T
V
F
S
N
V
T
D
D
M
R
I
A
K
E
E
I
F
G
P
V
Q
E
I
L
R
F
K
T
M
D
E
V
I
E
R
A
N
N
S
D
F
G
L
V
A
A
V
F
T
N
D
I
N
K
A
L
M
V
S
S
A
M
Q
A
G
T
V
W
I
N
C
Y
N
A
---------------------
G
E
F
G
L
R
E
Y
S
E
V
K
T
V
T
V
K
-
88
PsiBlast_CBE
89.49
39%
-78
- C2 -
1O9J
1
ALDH1_ELEED
A:
[13-495]
L
T
N
I
K
I
Q
H
T
K
L
-
F
I
N
N
E
W
H
E
S
V
S
G
K
T
F
P
V
F
N
P
A
T
E
E
K
I
C
-
E
V
E
E
A
D
K
E
D
V
D
K
A
V
K
A
A
R
E
A
F
QM
G
S
--
P
W
R
T
M
D
A
S
E
R
G
Q
L
I
Y
K
L
A
D
L
I
E
R
D
R
L
L
L
A
T
L
E
S
I
N
A
G
K
V
F
A
S
A
Y
L
M
-
D
L
D
Y
C
-
I
K
A
L
R
Y
C
A
G
W
A
D
K
I
Q
G
R
T
I
P
------
V
D
G
E
F
F
S
Y
T
R
H
E
P
I
G
V
C
G
L
I
F
P
W
N
A
P
M
I
L
L
A
C
K
I
G
P
A
L
C
C
G
N
T
V
I
V
K
P
A
E
Q
T
P
L
T
A
L
H
V
A
S
L
I
K
E
A
G
F
P
P
G
V
V
N
I
V
P
G
Y
G
P
T
A
G
A
A
I
S
S
H
M
D
V
D
K
V
A
F
T
G
S
T
E
V
G
K
M
I
Q
E
A
A
-
A
-
K
S
N
L
K
R
V
T
L
E
L
G
A
K
N
P
C
I
V
F
A
D
A
D
L
D
S
A
V
E
F
A
H
Q
G
V
F
T
N
Q
G
Q
S
C
I
A
A
S
K
L
F
V
E
E
A
I
Y
D
E
F
V
Q
R
S
V
E
R
A
K
K
Y
V
F
G
N
P
L
-
T
P
G
V
N
H
G
P
Q
I
N
K
A
Q
H
N
K
I
M
E
L
I
E
S
G
K
K
E
G
A
K
L
E
C
G
G
G
P
W
G
N
----
K
G
Y
F
I
Q
P
T
V
F
S
N
V
T
D
D
M
R
I
A
K
E
E
I
F
G
P
V
Q
Q
I
M
K
F
K
S
L
D
E
V
I
K
R
A
N
N
T
Y
Y
G
L
V
A
G
V
F
T
K
D
L
D
K
A
V
T
V
S
S
A
L
Q
A
G
T
V
W
V
N
C
Y
L
A
A
-
S
A
Q
S
P
A
G
G
F
K
M
-
S
G
H
G
R
E
M
G
E
Y
G
I
H
E
Y
T
E
V
K
T
V
T
M
K
-
85
PsiBlast_CBE
89.12
39%
-75
- C2 -
1O9J
2
ALDH1_ELEED
D:
[13-495]
L
T
N
I
K
I
Q
H
T
K
L
-
F
I
N
N
E
W
H
E
S
V
S
G
K
T
F
P
V
F
N
P
A
T
E
E
K
I
C
-
E
V
E
E
A
D
K
E
D
V
D
K
A
V
K
A
A
R
E
A
FQM
G
S
--
P
W
R
T
M
D
A
S
E
R
G
Q
L
I
Y
K
L
A
D
L
I
E
R
D
R
L
L
L
A
T
L
E
S
I
N
A
G
K
V
F
A
S
A
Y
L
M
-
D
L
D
Y
C
-
I
K
A
L
R
Y
C
A
G
W
A
D
K
I
Q
G
R
T
I
P
------
V
D
G
E
F
F
S
Y
T
R
H
E
P
I
G
V
C
G
L
I
F
P
W
N
A
P
M
I
L
L
A
C
K
I
G
P
A
L
C
C
G
N
T
V
I
V
K
P
A
E
Q
T
P
L
T
A
L
H
V
A
S
L
I
K
E
A
G
F
P
P
G
V
V
N
I
V
P
G
Y
G
P
T
A
G
A
A
I
S
S
H
M
D
V
D
K
V
A
F
T
G
S
T
E
V
G
K
M
I
Q
E
A
A
-
A
-
K
S
N
L
K
R
V
T
L
E
L
G
A
K
N
P
C
I
V
F
A
D
A
D
L
D
S
A
V
E
F
A
H
Q
G
V
F
T
N
Q
G
Q
S
C
I
A
A
S
K
L
F
V
E
E
A
I
Y
D
E
F
V
Q
R
S
V
E
R
A
K
K
Y
V
F
G
N
P
L
-
T
P
G
V
N
H
G
P
Q
I
N
K
A
Q
H
N
K
I
M
E
L
I
E
S
G
K
K
E
G
A
K
L
E
C
G
G
G
P
W
G
N
----
K
G
Y
F
I
Q
P
T
V
F
S
N
V
T
D
D
M
R
I
A
K
E
E
I
F
G
P
V
Q
Q
I
M
K
F
K
S
L
D
E
V
I
K
R
A
N
N
T
Y
Y
G
L
V
A
G
V
F
T
K
D
L
D
K
A
V
T
V
S
S
A
L
Q
A
G
T
V
W
V
N
C
Y
L
A
A
-
S
A
Q
S
P
A
G
G
F
K
M
-
S
G
H
G
R
E
M
G
E
Y
G
I
H
E
Y
T
E
V
K
T
V
T
M
K
-
15
PsiBlast_PDB
88.74
40%
-80
- C2 -
1BI9
1
AL1A2_RAT
A:
[22-493]
------------
F
I
N
N
E
W
Q
N
S
E
S
G
R
V
F
P
V
C
N
P
A
-
T
G
E
Q
V
C
E
V
Q
E
A
D
K
V
D
I
D
K
A
V
Q
A
A
R
L
A
F
SL
G
S
--
V
W
R
R
M
D
A
S
E
R
G
R
L
L
D
K
L
A
D
L
V
E
R
D
R
A
T
L
A
T
M
E
S
L
N
G
G
K
P
F
L
Q
A
F
-
Y
-
I
D
L
Q
G
V
I
K
T
L
R
Y
Y
A
G
W
A
D
K
I
H
G
M
T
I
P
------
V
D
G
D
Y
F
T
F
T
R
H
E
P
I
G
V
C
G
Q
I
I
P
W
N
F
P
L
L
M
F
T
W
K
I
A
P
A
L
C
C
G
N
T
V
V
I
K
P
A
E
Q
T
P
L
S
A
L
Y
M
G
A
L
I
K
E
A
G
F
P
P
G
V
V
N
I
L
P
G
Y
G
P
T
A
G
A
A
I
A
S
H
I
G
I
D
K
I
A
F
T
G
S
T
E
V
G
K
L
I
Q
E
A
A
G
R
-
S
N
L
K
R
-
V
T
L
E
L
G
G
K
S
P
N
I
I
F
A
D
A
D
L
D
Y
A
V
E
Q
A
H
Q
G
V
F
F
N
Q
G
Q
C
C
T
A
G
S
R
I
F
V
E
E
S
I
Y
E
E
F
V
K
R
S
V
E
R
A
K
R
R
I
V
G
S
P
F
-
D
P
T
T
E
Q
G
P
Q
I
D
K
K
Q
Y
N
K
I
L
E
L
I
Q
S
G
V
A
E
G
A
K
L
E
C
G
G
K
G
L
G
----
R
K
G
F
F
I
E
P
T
V
F
S
N
V
T
D
D
M
R
I
A
K
E
E
I
F
G
P
V
Q
E
I
L
R
F
K
T
M
D
E
V
I
E
R
A
N
N
S
D
F
G
L
V
A
A
V
F
T
N
D
I
N
K
A
L
M
V
S
S
A
M
Q
A
G
T
V
W
I
N
C
Y
-----------------------
G
E
F
G
L
R
E
Y
S
E
V
K
T
V
T
V
K
-
6
PsiBlast_PDB
88.60
41%
-70
- C2 -
5AC2
4
AL1A1_HUMAN
A:
[24-495]
------------
F
I
N
N
E
W
H
D
S
V
S
G
K
K
F
P
V
F
N
P
A
T
E
E
E
L
C
-
Q
V
E
E
G
D
K
E
D
V
D
K
A
V
K
A
A
R
Q
A
F
QI
G
S
--
P
W
R
T
M
D
A
S
E
R
G
R
L
L
Y
K
L
A
D
L
I
E
R
D
R
L
L
L
A
T
M
E
S
M
N
G
G
K
L
Y
S
N
A
Y
L
N
-
D
L
A
G
C
-
I
K
T
L
R
Y
C
A
G
W
A
D
K
I
Q
G
R
T
I
P
------
I
D
G
N
F
F
T
Y
T
R
H
E
P
I
G
V
C
G
Q
I
I
P
W
N
F
P
L
V
M
L
I
W
K
I
G
P
A
L
S
C
G
N
T
V
V
V
K
P
A
E
Q
T
P
L
T
A
L
H
V
A
S
L
I
K
E
A
G
F
P
P
G
V
V
N
I
V
P
G
Y
G
P
T
A
G
A
A
I
S
S
H
M
D
I
D
K
V
A
F
T
G
S
T
E
V
G
K
L
I
K
E
A
A
-
G
-
K
S
N
L
K
R
V
T
L
E
L
G
G
K
S
P
C
I
V
L
A
D
A
D
L
D
N
A
V
E
F
A
H
H
G
V
F
Y
H
Q
G
Q
C
C
I
A
A
S
R
I
F
V
E
E
S
I
Y
D
E
F
V
R
R
S
V
E
R
A
K
K
Y
I
L
G
N
P
L
-
T
P
G
V
T
Q
G
P
Q
I
D
K
E
Q
Y
D
K
I
L
D
L
I
E
S
G
K
K
E
G
A
K
L
E
C
G
G
G
P
W
G
N
----
K
G
Y
F
V
Q
P
T
V
F
S
N
V
T
D
E
M
R
I
A
K
E
E
I
F
G
P
V
Q
Q
I
M
K
F
K
S
L
D
D
V
I
K
R
A
N
N
T
F
Y
G
L
S
A
G
V
F
T
K
D
I
D
K
A
I
T
I
S
S
A
L
Q
A
G
T
V
W
V
N
C
Y
G
V
-
V
S
A
Q
C
P
F
G
G
F
K
M
-
S
G
N
G
R
E
L
G
E
Y
G
F
H
E
Y
T
E
V
K
T
V
T
V
K
-
4
PsiBlast_PDB
88.39
41%
-70
- C2 -
4WB9
4
AL1A1_HUMAN
A:
[24-495]
------------
F
I
N
N
E
W
H
D
S
V
S
G
K
K
F
P
V
F
N
P
A
T
E
E
E
L
C
-
Q
V
E
E
G
D
K
E
D
V
D
K
A
V
K
A
A
R
Q
A
F
QI
G
S
--
P
W
R
T
M
D
A
S
E
R
G
R
L
L
Y
K
L
A
D
L
I
E
R
D
R
L
L
L
A
T
M
E
S
M
N
G
G
K
L
Y
S
N
A
Y
L
N
-
D
L
A
G
C
-
I
K
T
L
R
Y
C
A
G
W
A
D
K
I
Q
G
R
T
I
P
------
I
D
G
N
F
F
T
Y
T
R
H
E
P
I
G
V
C
G
Q
I
I
P
W
N
F
P
L
V
M
L
I
W
K
I
G
P
A
L
S
C
G
N
T
V
V
V
K
P
A
E
Q
T
P
L
T
A
L
H
V
A
S
L
I
K
E
A
G
F
P
P
G
V
V
N
I
V
P
G
Y
G
P
T
A
G
A
A
I
S
S
H
M
D
I
D
K
V
A
F
T
G
S
T
E
V
G
K
L
I
K
E
A
A
-
G
-
K
S
N
L
K
R
V
T
L
E
L
G
G
K
S
P
C
I
V
L
A
D
A
D
L
D
N
A
V
E
F
A
H
H
G
V
F
Y
H
Q
G
Q
C
C
I
A
A
S
R
I
F
V
E
E
S
I
Y
D
E
F
V
R
R
S
V
E
R
A
K
K
Y
I
L
G
N
P
L
-
T
P
G
V
T
Q
G
P
Q
I
D
K
E
Q
Y
D
K
I
L
D
L
I
E
S
G
K
K
E
G
A
K
L
E
C
G
G
G
P
W
G
N
----
K
G
Y
F
V
Q
P
T
V
F
S
N
V
T
D
E
M
R
I
A
K
E
E
I
F
G
P
V
Q
Q
I
M
K
F
K
S
L
D
D
V
I
K
R
A
N
N
T
F
Y
G
L
S
A
G
V
F
T
K
D
I
D
K
A
I
T
I
S
S
A
L
Q
A
G
T
V
W
V
N
C
Y
G
V
-
V
S
A
Q
C
P
F
G
G
F
K
M
-
S
G
N
G
R
E
L
G
E
Y
G
F
H
E
Y
T
E
V
K
T
V
T
V
K
-
116
HHSearch
88.26
39%
-68
- C2 -
4QF6
3
?
A:
[16-491]
-----
L
N
E
E
I
K
M
F
I
N
G
E
F
V
S
A
I
G
G
K
T
F
E
T
Y
N
P
A
T
-
E
D
V
L
A
V
V
C
E
A
Q
E
E
D
I
D
A
A
V
K
A
A
R
S
A
---
F
E
SG
P
W
A
E
M
T
T
A
E
R
A
H
L
I
Y
K
L
A
D
L
I
E
E
H
R
E
E
L
A
Q
L
E
A
L
D
N
G
K
P
Y
Q
V
A
L
D
D
-
D
I
S
A
T
-
V
E
N
Y
R
Y
Y
A
G
W
T
T
K
I
I
G
Q
T
I
P
------
I
S
K
D
Y
L
N
Y
T
R
H
E
P
V
G
V
V
G
Q
I
I
P
W
N
F
P
L
V
M
S
S
W
K
M
G
A
A
L
A
T
G
C
T
I
V
L
K
P
A
S
Q
T
P
L
S
L
L
Y
A
A
K
L
F
K
E
A
G
F
P
N
G
V
V
N
F
V
P
G
F
G
P
E
A
G
A
A
I
V
N
H
H
D
I
D
K
V
A
F
T
G
S
T
V
T
G
K
Y
I
M
R
Q
S
-
A
-
E
M
I
K
H
-
V
T
L
E
L
G
G
K
S
P
N
I
I
L
E
D
A
D
L
E
E
A
I
N
G
A
F
Q
G
I
M
Y
N
H
G
Q
N
C
S
A
G
S
R
V
F
V
H
R
K
H
Y
E
T
V
V
D
A
L
V
K
M
A
N
N
V
K
L
G
A
G
M
-
E
K
E
T
E
M
G
P
L
V
S
K
K
Q
Q
E
R
V
L
N
Y
I
E
Q
G
K
K
E
G
A
T
V
A
A
G
G
E
R
----
A
L
E
K
G
Y
F
V
K
P
T
V
F
T
D
V
T
D
D
M
T
I
V
K
E
E
I
F
G
P
V
V
V
V
L
P
F
D
S
T
E
E
V
I
E
R
A
N
N
S
S
Y
G
L
A
A
G
V
W
T
Q
N
I
K
T
G
H
Q
V
A
N
K
L
K
A
G
T
V
W
I
N
D
-
Y
N
L
E
N
A
A
A
P
F
G
G
Y
K
Q
S
G
I
G
-
R
E
L
G
S
Y
A
L
D
N
Y
T
E
V
K
S
V
W
V
--
2
PsiBlast_PDB
88.21
41%
-70
- C2 -
4WP7
2
AL1A1_HUMAN
A:
[24-495]
------------
F
I
N
N
E
W
H
D
S
V
S
G
K
K
F
P
V
F
N
P
A
T
E
E
E
L
C
-
Q
V
E
E
G
D
K
E
D
V
D
K
A
V
K
A
A
R
Q
A
F
QI
G
S
--
P
W
R
T
M
D
A
S
E
R
G
R
L
L
Y
K
L
A
D
L
I
E
R
D
R
L
L
L
A
T
M
E
S
M
N
G
G
K
L
Y
S
N
A
Y
L
S
-
D
L
A
G
C
-
I
K
T
L
R
Y
C
A
G
W
A
D
K
I
Q
G
R
T
I
P
------
I
D
G
N
F
F
T
Y
T
R
H
E
P
I
G
V
C
G
Q
I
I
P
W
N
F
P
L
V
M
L
I
W
K
I
G
P
A
L
S
C
G
N
T
V
V
V
K
P
A
E
Q
T
P
L
T
A
L
H
V
A
S
L
I
K
E
A
G
F
P
P
G
V
V
N
I
V
P
G
Y
G
P
T
A
G
A
A
I
S
S
H
M
D
I
D
K
V
A
F
T
G
S
T
E
V
G
K
L
I
K
E
A
A
-
G
-
K
S
N
L
K
R
V
T
L
E
L
G
G
K
S
P
C
I
V
L
A
D
A
D
L
D
N
A
V
E
F
A
H
H
G
V
F
Y
H
Q
G
Q
C
C
I
A
A
S
R
I
F
V
E
E
S
I
Y
D
E
F
V
R
R
S
V
E
R
A
K
K
Y
I
L
G
N
P
L
-
T
P
G
V
T
Q
G
P
Q
I
D
K
E
Q
Y
D
K
I
L
D
L
I
E
S
G
K
K
E
G
A
K
L
E
C
G
G
G
P
W
G
N
----
K
G
Y
F
V
Q
P
T
V
F
S
N
V
T
D
E
M
R
I
A
K
E
E
I
F
G
P
V
Q
Q
I
M
K
F
K
S
L
D
D
V
I
K
R
A
N
N
T
F
Y
G
L
S
A
G
V
F
T
K
D
I
D
K
A
I
T
I
S
S
A
L
Q
A
G
T
V
W
V
N
C
Y
G
V
-
V
S
A
Q
C
P
F
G
G
F
K
M
-
S
G
N
G
R
E
L
G
E
Y
G
F
H
E
Y
T
E
V
K
T
V
T
V
K
-
49
PsiBlast_CBE
88.19
40%
-77
- C2 -
1BI9
2
AL1A2_RAT
D:
[22-493]
------------
F
I
N
N
E
W
Q
N
S
E
S
G
R
V
F
P
V
C
N
P
A
-
T
G
E
Q
V
C
E
V
Q
E
A
D
K
V
D
I
D
K
A
V
Q
A
A
R
L
A
FSL
G
S
--
V
W
R
R
M
D
A
S
E
R
G
R
L
L
D
K
L
A
D
L
V
E
R
D
R
A
T
L
A
T
M
E
S
L
N
G
G
K
P
F
L
Q
A
F
-
Y
-
I
D
L
Q
G
V
I
K
T
L
R
Y
Y
A
G
W
A
D
K
I
H
G
M
T
I
P
------
V
D
G
D
Y
F
T
F
T
R
H
E
P
I
G
V
C
G
Q
I
I
P
W
N
F
P
L
L
M
F
T
W
K
I
A
P
A
L
C
C
G
N
T
V
V
I
K
P
A
E
Q
T
P
L
S
A
L
Y
M
G
A
L
I
K
E
A
G
F
P
P
G
V
V
N
I
L
P
G
Y
G
P
T
A
G
A
A
I
A
S
H
I
G
I
D
K
I
A
F
T
G
S
T
E
V
G
K
L
I
Q
E
A
A
G
R
-
S
N
L
K
R
-
V
T
L
E
L
G
G
K
S
P
N
I
I
F
A
D
A
D
L
D
Y
A
V
E
Q
A
H
Q
G
V
F
F
N
Q
G
Q
C
C
T
A
G
S
R
I
F
V
E
E
S
I
Y
E
E
F
V
K
R
S
V
E
R
A
K
R
R
I
V
G
S
P
F
-
D
P
T
T
E
Q
G
P
Q
I
D
K
K
Q
Y
N
K
I
L
E
L
I
Q
S
G
V
A
E
G
A
K
L
E
C
G
G
K
G
L
G
----
R
K
G
F
F
I
E
P
T
V
F
S
N
V
T
D
D
M
R
I
A
K
E
E
I
F
G
P
V
Q
E
I
L
R
F
K
T
M
D
E
V
I
E
R
A
N
N
S
D
F
G
L
V
A
A
V
F
T
N
D
I
N
K
A
L
M
V
S
S
A
M
Q
A
G
T
V
W
I
N
C
Y
N
A
-
L
N
------------------
G
E
F
G
L
R
E
Y
S
E
V
K
T
V
T
V
K
-
94
PsiBlast_CBE
87.86
37%
-72
- C2 -
4O6R
9
?
C:
[14-485]
------------
F
I
D
G
R
F
V
D
A
V
D
R
G
T
I
D
V
L
N
P
H
D
-
G
S
V
I
T
K
I
A
A
A
T
A
A
D
V
D
L
A
V
D
A
A
T
R
A
---
F
P
--
A
W
S
A
M
P
A
A
E
R
G
R
L
L
L
R
L
A
D
A
I
E
A
N
T
E
A
L
A
Q
L
E
S
L
D
T
G
H
P
I
R
D
S
R
-
A
L
D
V
P
R
T
-
A
A
C
F
R
Y
F
G
G
M
A
D
K
L
Q
G
S
V
I
P
------
V
D
T
G
F
L
N
Y
V
Q
R
A
P
I
G
V
V
G
Q
I
V
P
W
N
F
P
L
M
F
T
S
W
K
M
G
P
A
L
A
A
G
N
T
V
V
L
K
P
S
E
I
T
P
L
S
T
L
R
I
V
E
L
M
A
E
V
G
F
P
A
G
V
V
N
I
V
P
G
Y
G
H
T
A
G
Q
R
L
A
E
H
P
G
V
G
K
I
A
F
T
G
S
T
A
T
G
R
R
I
V
E
A
S
-
Q
-
G
N
L
K
R
-
V
Q
L
E
L
G
G
K
G
A
N
I
V
F
D
D
A
N
L
D
A
A
I
N
G
A
A
W
A
I
F
H
N
Q
G
Q
A
C
I
A
G
S
R
L
V
L
H
E
R
I
A
D
A
F
L
E
R
F
V
A
L
A
S
S
I
R
I
G
N
P
L
-
D
P
N
T
E
M
G
P
L
T
S
K
Q
H
L
D
R
V
L
S
Y
V
D
V
A
R
E
Q
G
G
R
V
L
T
G
G
S
A
P
Q
D
P
A
L
A
N
G
Y
Y
V
R
P
T
I
V
E
A
K
H
A
T
D
R
V
A
Q
E
E
V
F
G
P
F
V
T
V
L
R
F
G
S
D
D
E
A
L
A
I
A
N
A
T
E
Y
G
L
G
S
G
L
W
T
N
D
L
S
R
A
H
R
M
A
A
R
I
D
A
G
M
C
W
I
N
C
Y
K
R
-
V
N
P
G
S
P
F
G
G
V
G
K
-
S
G
Y
G
R
E
M
G
F
E
A
M
H
D
Y
T
E
A
R
S
V
W
V
N
-
3
PsiBlast_PDB
87.86
41%
-70
- C2 -
4X4L
6
AL1A1_HUMAN
A:
[24-495]
------------
F
I
N
N
E
W
H
D
S
V
S
G
K
K
F
P
V
F
N
P
A
T
E
E
E
L
C
-
Q
V
E
E
G
D
K
E
D
V
D
K
A
V
K
A
A
R
Q
A
F
QI
G
S
--
P
W
R
T
M
D
A
S
E
R
G
R
L
L
Y
K
L
A
D
L
I
E
R
D
R
L
L
L
A
T
M
E
S
M
N
G
G
K
L
Y
S
N
A
Y
L
S
-
D
L
A
G
C
-
I
K
T
L
R
Y
C
A
G
W
A
D
K
I
Q
G
R
T
I
P
------
I
D
G
N
F
F
T
Y
T
R
H
E
P
I
G
V
C
G
Q
I
I
P
W
N
F
P
L
V
M
L
I
W
K
I
G
P
A
L
S
C
G
N
T
V
V
V
K
P
A
E
Q
T
P
L
T
A
L
H
V
A
S
L
I
K
E
A
G
F
P
P
G
V
V
N
I
V
P
G
Y
G
P
T
A
G
A
A
I
S
S
H
M
D
I
D
K
V
A
F
T
G
S
T
E
V
G
K
L
I
K
E
A
A
-
G
-
K
S
N
L
K
R
V
T
L
E
L
G
G
K
S
P
C
I
V
L
A
D
A
D
L
D
N
A
V
E
F
A
H
H
G
V
F
Y
H
Q
G
Q
C
C
I
A
A
S
R
I
F
V
E
E
S
I
Y
D
E
F
V
R
R
S
V
E
R
A
K
K
Y
I
L
G
N
P
L
-
T
P
G
V
T
Q
G
P
Q
I
D
K
E
Q
Y
D
K
I
L
D
L
I
E
S
G
K
K
E
G
A
K
L
E
C
G
G
G
P
W
G
N
----
K
G
Y
F
V
Q
P
T
V
F
S
N
V
T
D
E
M
R
I
A
K
E
E
I
F
G
P
V
Q
Q
I
M
K
F
K
S
L
D
D
V
I
K
R
A
N
N
T
F
Y
G
L
S
A
G
V
F
T
K
D
I
D
K
A
I
T
I
S
S
A
L
Q
A
G
T
V
W
V
N
C
Y
G
V
-
V
S
A
Q
C
P
F
G
G
F
K
M
-
S
G
N
G
R
E
L
G
E
Y
G
F
H
E
Y
T
E
V
K
T
V
T
V
K
-
115
HHSearch
87.85
36%
-78
- C2 -
4O5H
5
?
A:
[28-509]
------
A
K
P
K
Q
M
L
I
G
A
E
W
S
D
A
A
S
G
R
Q
L
D
V
V
N
P
A
D
-
G
T
V
I
A
R
V
P
E
A
D
E
R
D
V
Q
Q
A
V
A
A
A
R
R
A
---
F
D
AG
P
W
R
T
A
K
T
T
D
R
E
R
L
M
L
V
L
A
D
L
I
E
A
N
A
R
E
L
A
E
I
E
S
L
D
N
G
K
P
V
M
V
A
Q
G
L
-
D
V
A
M
A
-
A
Q
C
F
R
Y
M
A
G
W
A
T
K
I
E
G
S
V
I
D
AGMPY
L
P
D
S
E
I
F
A
Y
T
R
K
E
P
V
G
V
V
G
A
I
I
P
W
N
F
P
L
L
M
A
A
W
K
I
A
P
A
L
A
T
G
C
T
V
V
L
K
P
A
E
D
T
P
L
S
A
L
R
L
G
E
L
I
Q
A
A
G
F
P
D
G
V
V
N
I
V
T
G
Y
G
H
T
A
G
A
A
L
S
R
D
P
R
I
D
K
I
A
F
T
G
S
T
Q
T
G
K
T
I
G
H
A
A
-
L
-
D
N
M
T
R
-
M
S
L
E
L
G
G
K
S
P
V
I
V
L
P
D
V
D
L
D
K
A
A
Q
G
V
A
N
A
I
F
F
N
Q
G
Q
V
C
T
A
G
S
R
A
Y
I
H
S
K
V
F
D
G
V
I
E
R
V
A
K
I
A
A
S
L
K
I
G
P
G
M
-
D
P
A
T
Q
I
G
P
L
V
S
A
K
Q
R
E
R
V
C
G
Y
I
D
S
G
F
G
E
G
A
R
A
A
A
G
G
R
A
I
----
D
G
P
G
F
F
V
E
P
T
V
L
V
D
T
T
Q
A
M
R
V
V
R
E
E
I
F
G
P
V
L
V
A
M
P
F
D
D
V
D
T
A
V
Q
L
A
N
D
T
P
Y
G
L
G
A
S
I
W
S
N
D
L
S
A
I
H
K
L
V
P
R
I
A
A
G
T
V
W
V
N
C
-
H
S
L
L
D
N
A
L
P
F
G
G
M
K
Q
S
G
F
G
-
R
E
L
G
R
A
V
I
D
Q
Y
T
E
S
K
S
V
M
M
N
-
1
PsiBlast_PDB
87.81
41%
-69
- C2 -
4WJ9
1
AL1A1_HUMAN
A:
[24-495]
------------
F
I
N
N
E
W
H
D
S
V
S
G
K
K
F
P
V
F
N
P
A
T
E
E
E
L
C
-
Q
V
E
E
G
D
K
E
D
V
D
K
A
V
K
A
A
R
Q
A
F
QI
G
S
--
P
W
R
T
M
D
A
S
E
R
G
R
L
L
Y
K
L
A
D
L
I
E
R
D
R
L
L
L
A
T
M
E
S
M
N
G
G
K
L
Y
S
N
A
Y
L
S
-
D
L
A
G
C
-
I
K
T
L
R
Y
C
A
G
W
A
D
K
I
Q
G
R
T
I
P
------
I
D
G
N
F
F
T
Y
T
R
H
E
P
I
G
V
C
G
Q
I
I
P
W
N
F
P
L
V
M
L
I
W
K
I
G
P
A
L
S
C
G
N
T
V
V
V
K
P
A
E
Q
T
P
L
T
A
L
H
V
A
S
L
I
K
E
A
G
F
P
P
G
V
V
N
I
V
P
G
Y
G
P
T
A
G
A
A
I
S
S
H
M
D
I
D
K
V
A
F
T
G
S
T
E
V
G
K
L
I
K
E
A
A
-
G
-
K
S
N
L
K
R
V
T
L
E
L
G
G
K
S
P
C
I
V
L
A
D
A
D
L
D
N
A
V
E
F
A
H
H
G
V
F
Y
H
Q
G
Q
C
C
I
A
A
S
R
I
F
V
E
E
S
I
Y
D
E
F
V
R
R
S
V
E
R
A
K
K
Y
I
L
G
N
P
L
-
T
P
G
V
T
Q
G
P
Q
I
D
K
E
Q
Y
D
K
I
L
D
L
I
E
S
G
K
K
E
G
A
K
L
E
C
G
G
G
P
W
G
N
----
K
G
Y
F
V
Q
P
T
V
F
S
N
V
T
D
E
M
R
I
A
K
E
E
I
F
G
P
V
Q
Q
I
M
K
F
K
S
L
D
D
V
I
K
R
A
N
N
T
F
Y
G
L
S
A
G
V
F
T
K
D
I
D
K
A
I
T
I
S
S
A
L
Q
A
G
T
V
W
V
N
C
Y
G
V
-
V
S
A
Q
C
P
F
G
G
F
K
M
-
S
G
N
G
R
E
L
G
E
Y
G
F
H
E
Y
T
E
V
K
T
V
T
V
K
-
5
PsiBlast_PDB
87.80
41%
-67
- C2 -
4WPN
4
AL1A1_HUMAN
A:
[24-495]
------------
F
I
N
N
E
W
H
D
S
V
S
G
K
K
F
P
V
F
N
P
A
T
E
E
E
L
C
-
Q
V
E
E
G
D
K
E
D
V
D
K
A
V
K
A
A
R
Q
A
F
QI
G
S
--
P
W
R
T
M
D
A
S
E
R
G
R
L
L
Y
K
L
A
D
L
I
E
R
D
R
L
L
L
A
T
M
E
S
M
N
G
G
K
L
Y
S
N
A
Y
L
N
-
D
L
A
G
C
-
I
K
T
L
R
Y
C
A
G
W
A
D
K
I
Q
G
R
T
I
P
------
I
D
G
N
F
F
T
Y
T
R
H
E
P
I
G
V
C
G
Q
I
I
P
W
N
F
P
L
V
M
L
I
W
K
I
G
P
A
L
S
C
G
N
T
V
V
V
K
P
A
E
Q
T
P
L
T
A
L
H
V
A
S
L
I
K
E
A
G
F
P
P
G
V
V
N
I
V
P
G
Y
G
P
T
A
G
A
A
I
S
S
H
M
D
I
D
K
V
A
F
T
G
S
T
E
V
G
K
L
I
K
E
A
A
-
G
-
K
S
N
L
K
R
V
T
L
E
L
G
G
K
S
P
C
I
V
L
A
D
A
D
L
D
N
A
V
E
F
A
H
H
G
V
F
Y
H
Q
G
Q
C
C
I
A
A
S
R
I
F
V
E
E
S
I
Y
D
E
F
V
R
R
S
V
E
R
A
K
K
Y
I
L
G
N
P
L
-
T
P
G
V
T
Q
G
P
Q
I
D
K
E
Q
Y
D
K
I
L
D
L
I
E
S
G
K
K
E
G
A
K
L
E
C
G
G
G
P
W
G
N
----
K
G
Y
F
V
Q
P
T
V
F
S
N
V
T
D
E
M
R
I
A
K
E
E
I
F
G
P
V
Q
Q
I
M
K
F
K
S
L
D
D
V
I
K
R
A
N
N
T
F
Y
G
L
S
A
G
V
F
T
K
D
I
D
K
A
I
T
I
S
S
A
L
Q
A
G
T
V
W
V
N
C
Y
G
V
-
V
S
A
Q
C
P
F
G
G
F
K
M
-
S
G
N
G
R
E
L
G
E
Y
G
F
H
E
Y
T
E
V
K
T
V
T
V
K
-
14
PsiBlast_PDB
87.75
40%
-77
- C2 -
4X2Q
1
AL1A2_HUMAN
A:
[27-498]
------------
F
I
N
N
E
W
Q
N
S
E
S
G
R
V
F
P
V
Y
N
P
A
-
T
G
E
Q
V
C
E
V
Q
E
A
D
K
A
D
I
D
K
A
V
Q
A
A
R
L
A
F
SL
G
S
--
V
W
R
R
M
D
A
S
E
R
G
R
L
L
D
K
L
A
D
L
V
E
R
D
R
A
V
L
A
T
M
E
S
L
N
G
G
K
P
F
L
Q
A
F
-
Y
-
V
D
L
Q
G
V
I
K
T
F
R
Y
Y
A
G
W
A
D
K
I
H
G
M
T
I
P
------
V
D
G
D
Y
F
T
F
T
R
H
E
P
I
G
V
C
G
Q
I
I
P
W
N
F
P
L
L
M
F
A
W
K
I
A
P
A
L
C
C
G
N
T
V
V
I
K
P
A
E
Q
T
P
L
S
A
L
Y
M
G
A
L
I
K
E
A
G
F
P
P
G
V
I
N
I
L
P
G
Y
G
P
T
A
G
A
A
I
A
S
H
I
G
I
D
K
I
A
F
T
G
S
T
E
V
G
K
L
I
Q
E
A
A
G
R
-
S
N
L
K
R
-
V
T
L
E
L
G
G
K
S
P
N
I
I
F
A
D
A
D
L
D
Y
A
V
E
Q
A
H
Q
G
V
F
F
N
Q
G
Q
C
C
T
A
G
S
R
I
F
V
E
E
S
I
Y
E
E
F
V
R
R
S
V
E
R
A
K
R
R
V
V
G
S
P
F
-
D
P
T
T
E
Q
G
P
Q
I
D
K
K
Q
Y
N
K
I
L
E
L
I
Q
S
G
V
A
E
G
A
K
L
E
C
G
G
K
G
L
G
----
R
K
G
F
F
I
E
P
T
V
F
S
N
V
T
D
D
M
R
I
A
K
E
E
I
F
G
P
V
Q
E
I
L
R
F
K
T
M
D
E
V
I
E
R
A
N
N
S
D
F
G
L
V
A
A
V
F
T
N
D
I
N
K
A
L
T
V
S
S
A
M
Q
A
G
T
V
W
I
N
C
Y
-----------------------
G
E
F
G
L
R
E
Y
S
E
V
K
T
V
T
V
K
-