@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : bsu09570: (2016-06-15 )
MKLAGLSREVEENLNKGSWIRKLFDEGARLKKEFGEDQVFDFSLGNPIVEPPEAFKRALIEEAEKGSHGYIQNQGLLAAREKVAQFLGSRFEADFSAERIVMTVGAGGALNVALKSIVNPGEEVIILAPYFAEYKLYIENYGGKAVSCPLTSRFEIDIEAVRQSITPQTKGLILNTPHNPTGTVLSQKNIDDLGALLKEIEEKSGQTIYVLFDEPYSQLIYDEELANPFQSYHRVILASSFSKDLGIAGERLGYIGLDSRMPDADLLINAFVYCNRTLGFVNAPVMMQRAVARMDDLRVDASAYKERRDLMVDILKEAGFEFEMPKGGFFVFPKSPIEDEVAFCVHAAQKYKLLIVPSSGFGMSGHFRLSFSVPIEQIKNSRDIFISLYKDFA
Atome Classification :
(20 SA)
.........10........20........30........40.......----.50..----......60...----.....70........80........90-...-----...-.-..100.......110.......120-........130.......140.--......150.--.------------.--......160.......170.......180.......190.......200....------...210.......220-.----.------....----.---230........240.......250.......260.........270..-...------.-.----.------280.....-..290-------.----.....----------.----.-----------300----..----.......310.....-.-.320.......330-..---....----------------.----340.......350.......360.-------.--.....370.......380.......390.
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MKLAG
L
S
R
E
V
E
E
NLN
K
G
S
W
I
R
K
L
F
D
E
G
A
R
L
K
K
E
FGED
Q
V
F
D
FSLGNPI----VE
P
P
E
----
A
F
K
R
A
L
I
E
E
A
E----KGSHGYIQNQ
G
L
L
A
A
R
E
K
V
A
Q
F
L
G
S
R
--FEA-----DFS-A-
E
R
I
V
M
T
VGAG
G
A
L
N
V
A
L
K
S
IVNP-G-E
E
V
I
I
LAPYF
A
E
Y
K
L
Y
I
ENYGG--
K
A
VSCPL--T--
S
------------
R
--
F
E
I
D
I
E
A
V
R
Q
SITPQTK
G
L
I
L
NTPHNPTG
T
V
LSQKN
I
D
D
L
G
A
L
L
K
E
I
E
E
KSG
Q
------
T
I
Y
V
L
FDE
P
Y
S
Q
L
I
Y
D
-
E
----
E
------LA
N
P
----
F
---
Q
-
S
Y
H
R
V
I
L
A
SSFSKDLGIAGE
R
L
G
YIGLDSR--MP
D
A
D
L
L
I
N
A
F
-
V
Y
-CNR------T-L----G------FVN
A
P
V
M
M
-
Q
R
A
V
--------
A
----
R
M
D
DL----------R----V-----------
D
------
A
S
----
A
Y
K
E
R
R
D
L
M
V
D
I
L
K
E-A-G
F
E
FEMPKG
G
F
F
V
F-PK---SP
I
E
----------------
D
----
E
V
A
F
C
V
HAAQ
K
Y
K
L
L
I
V
PSSGFGM-------
S
--
G
H
F
R
L
S
F
SV
P
I
E
Q
IKNSRD
I
F
I
S
L
Y
K
DFA
1
PsiBlast_PDB
95.48
34%
-119
- C1 -
3ELE
4
?
A:
[16-396]
-----------------
S
A
I
R
E
L
F
E
Y
G
K
K
R
A
A
I
V
G
K
E
N
V
Y
D
F
S
I
G
N
P
S
----
I
P
A
P
Q
I
V
N
D
T
I
K
E
L
V
T
D
Y
D
S
----
V
A
L
H
G
Y
T
S
A
Q
G
D
V
E
T
R
A
A
I
A
E
F
L
N
N
T
--
H
G
T
-----
H
F
N
-
A
-
D
N
L
Y
M
T
M
G
A
A
A
S
L
S
I
C
F
R
A
L
T
S
D
-
A
Y
D
E
F
I
T
I
A
P
Y
F
P
E
Y
K
V
F
V
N
A
A
G
A
--
R
L
V
E
V
P
A
D-
T
--
E
------------
H
--
F
Q
I
D
F
D
A
L
E
E
R
I
N
A
H
T
R
G
V
I
I
N
S
P
N
N
P
S
G
T
V
Y
S
E
E
T
I
K
K
L
S
D
L
L
E
K
K
S
K
E
I
G
R
------
P
I
F
I
I
A
D
E
P
Y
R
E
I
V
Y
D
-
G
-----------
I
K
V
P
----
F
VT-
K
-
Y
Y
D
N
T
L
V
C
Y
S
Y
S
K
S
L
S
L
P
G
E
R
I
G
Y
V
L
V
P
D
E
--
V
Y
D
K
A
E
L
Y
A
A
V
-
C
G
-
A
G
R
------
A
-
L
----
G
------
Y
V
C
A
P
S
L
F
-
Q
K
M
I
--------
V
----
K
C
Q
G
A
----------
T
----
G
-----------
D
------
I
N
----
A
Y
K
E
N
R
D
L
L
Y
E
G
L
T
R
-
I
-
G
Y
H
C
F
K
P
D
G
A
F
Y
M
F
-
V
K
---
A
L
E
D
----------------
D
----
S
N
A
F
C
E
K
A
K
E
E
-
D
V
L
I
V
A
A
D
G
F
G
C
-------
P
--
G
W
V
R
I
S
Y
C
V
D
R
E
M
I
K
H
S
M
P
A
F
E
K
I
Y
K
K
Y
-
34
HHSearch
92.26
33%
-123
- C1 -
3ELE
4
?
A:
[7-396]
--------
S
M
Y
Q
L
G
S
V
R
S
A
I
R
E
L
F
E
Y
G
K
K
R
A
A
I
V
G
K
E
N
V
Y
D
F
S
I
G
N
P
S
----
I
P
A
P
Q
----
I
V
N
D
T
I
K
E
L
V
T
DYD
S
V
A
L
H
G
Y
T
S
A
Q
G
D
V
E
T
R
A
A
I
A
E
F
L
N
N
T
--
H
G
T
-----
H
F
N
-
A
-
D
N
L
Y
M
T
M
G
A
A
A
S
L
S
I
C
F
R
A
L
T
S
D
A
Y
-
D
E
F
I
T
I
A
P
Y
F
P
E
Y
K
V
F
V
N
A
A
G
A
--
R
L
V
E
V
P
A
--
D
T-
E
------------
H
--
F
Q
I
D
F
D
A
L
E
E
R
I
N
A
H
T
R
G
V
I
I
N
S
P
N
N
P
S
G
T
V
Y
S
E
E
T
I
K
K
L
S
D
L
L
E
------
K
K
S
K
E
I
G
R
P
I
F
I
I
A
D
E
P
Y
R
E
I
V
Y
D
G
I
----
K
------
V
P
F
V
----
T
---
K
-
Y
Y
D
N
T
L
V
C
Y
S
Y
S
K
S
L
S
L
P
G
E
R
I
G
Y
V
L
V
P
D
------
E
--
V
Y
D
K
A
-
E
L
-
Y
A
A
V
C
G
A
G
R
A
-
L
----
G
------
Y
V
C
A
P
S
L
F
-
Q
K
M
I
--------
V
----
K
C
Q
G
-----------
A
----
T
-----------
G
D-----
I
N
----
A
Y
K
E
N
R
D
L
L
Y
E
G
L
T
R
-
I
-
G
Y
H
C
F
K
P
D
G
A
F
Y
M
F
-
V
K
---
A
L
E
D
----------------
D
----
S
N
A
F
C
E
K
A
-
K
E
E
D
V
L
I
V
A
A
D
G
F
G
C
-------
P
--
G
W
V
R
I
S
Y
C
V
D
R
E
M
I
K
H
S
M
P
A
F
E
K
I
Y
K
K
Y
-
32
HHSearch
74.28
30%
-113
- C1 -
1GD9
2
?
A:
[3-386]
-----
L
S
D
R
L
E
L
V
--
S
A
S
E
I
R
K
L
F
D
I
A
A
------
G
M
K
D
V
I
S
L
G
I
G
E
P
D
----
F
D
T
P
Q
----
H
I
K
E
Y
A
K
E
A
L
D
----
K
G
L
T
H
Y
G
P
N
I
G
L
L
E
L
R
E
A
I
A
E
K
L
K
K
Q
--
N
G
I
-----
E
A
D
P
K
-
T
E
I
M
V
L
L
G
A
N
Q
A
F
L
M
G
L
S
A
F
L
K
D
-
G
-
E
E
V
L
I
P
T
P
A
F
V
S
Y
A
P
A
V
I
L
A
G
G
--
K
P
V
E
V
P
T
--
Y
EE
D
------------
E
--
F
R
L
N
V
D
E
L
K
K
Y
V
T
D
K
T
R
A
L
I
I
N
S
P
C
N
P
T
G
A
V
L
T
K
K
D
L
E
E
I
A
D
F
V
V
------
E
H
------
D
L
I
V
I
S
D
E
V
Y
E
H
F
I
Y
D
D
A
----
R
------
H
Y
S
I
ASL-
D
---
G
-
M
F
E
R
T
I
T
V
N
G
F
S
K
T
F
A
M
T
G
W
R
L
G
F
V
A
A
P
S
------
W
--
I
I
E
R
M
-
V
K
-
F
Q
M
--------
Y
----
N
------
A
T
C
P
V
T
F
I
-
Q
Y
A
A
--------
A
----
K
A
L
K
-----------
D
----
E
R
S
W
K
A
V
-----
E
E
M
----
R
K
----
E
Y
D
R
R
R
K
L
V
W
K
R
L
N
E
-
M
-
G
L
P
T
V
K
P
K
G
A
F
Y
I
F
-
P
R
---
I
R
D
T
GL--------------
T
----
S
K
K
F
S
E
L
M
L
K
E
A
R
V
A
V
V
P
G
S
A
F
G
K
AG-----
E
--
G
Y
V
R
I
S
Y
A
T
A
Y
E
K
L
E
E
A
M
D
R
M
E
R
V
L
K
E
R
-
9
PsiBlast_PDB
73.51
27%
-102
- C1 -
1B5P
3
AAT_THET8
A:
[1-378]
--
M
R
G
L
S
R
R
V
Q
A
M
--
K
P
S
A
T
V
A
V
N
A
K
A
L
E
L
R
R
Q
-
G
V
D
L
V
-
A
L
T
A
G
E
P
D
----
F
D
T
P
E
----
H
V
K
E
A
A
R
R
A
L
A
----
Q
G
K
T
K
Y
A
P
P
A
G
I
P
E
L
R
E
A
L
A
E
K
F
R
R
E
--
N
G
L
-----
S
V
T
-
P
-
E
E
T
I
V
T
V
G
G
S
Q
A
L
F
N
L
F
Q
A
I
L
D
P
-
G
-
D
E
V
I
V
L
S
P
Y
W
V
S
Y
P
E
M
V
R
F
A
G
G
--
V
V
V
E
V
E
T
--
L
--
P
------------
E
EG
F
V
P
D
P
E
R
V
R
R
A
I
T
P
R
T
K
A
L
V
V
N
S
P
N
N
P
T
G
A
V
Y
P
K
E
V
L
E
A
L
A
R
L
A
V
E
------
H
------
D
F
Y
L
V
S
D
E
I
Y
E
H
L
L
Y
E
-
G
----
E
------
H
F
S
P
----
G
---
R
V
A
P
E
H
T
L
T
V
N
G
A
A
K
A
F
A
M
T
G
W
R
I
G
Y
A
C
--------
G
P
K
E
V
I
K
A
M
-
A
S
-
V
S
R
------
Q
------
S
------
T
T
S
P
D
T
I
A
-
Q
W
A
T
L
E
A
L
TN
Q
E
A
----
S
R
A
F
V
----------
E
----
M
-----------
A
------
R
E
----
A
Y
R
R
R
R
D
L
L
L
E
G
L
T
A
-
L
-
G
L
K
A
V
R
P
S
G
A
F
Y
V
L
M
D
T
---
S
P
I
A
----------------
P
----
D
E
V
R
A
A
E
R
L
L
E
A
G
V
A
V
V
P
G
T
D
F
A
A
-------
F
--
G
H
V
R
L
S
Y
A
T
S
E
E
N
L
R
K
A
L
E
R
F
--------
43
HHSearch
73.38
25%
-115
- C1 -
3E2Y
6
KAT3_MOUSE
A:
[21-409]
----------------------------------
A
D
P
S
V
V
N
L
G
Q
G
F
P
D
----
I
S
P
P
S
----
Y
V
K
E
E
L
S
K
A
A
F
I---
D
N
M
N
Q
Y
T
R
G
F
G
H
P
A
L
V
K
A
L
S
C
L
Y
G
K
I
--
Y
Q
R
-----
Q
I
D
P
N
-
E
E
I
L
V
A
V
G
A
Y
G
S
L
F
N
S
I
Q
G
L
V
D
P
-
G
-
D
E
V
I
I
M
V
P
F
Y
D
C
Y
E
P
M
V
R
M
A
G
A
--
V
P
V
F
I
P
L
--
R
--
S
K
PTDGMKWTSS-
D
--
W
T
F
D
P
R
E
L
E
S
K
F
S
S
K
T
K
A
I
I
L
N
T
P
H
N
P
L
G
K
V
Y
T
R
Q
E
L
Q
V
I
A
D
L
C
V
------
K
H
------
D
T
L
C
I
S
D
E
V
Y
E
W
L
V
Y
T
G
H
----
T
------
H
V
K
I
ATL-
P
---
G
-
M
W
E
R
T
I
T
I
G
S
A
G
K
T
F
S
V
T
G
W
K
L
G
W
S
I
G
P
A
------
H
--
L
I
K
H
L
-
Q
T
-
V
Q
Q
--------
N
----
S
------
F
Y
T
C
A
T
P
L
-
Q
A
A
L
--------
A
----
E
A
F
W
I
D
I
K
R
M
DDPEC
Y
----
F
-----------
N
S
L
----
P
K
----
E
L
E
V
K
R
D
R
M
V
R
L
L
N
S
-
V
-
G
L
K
P
I
V
P
D
G
G
Y
F
I
I
-
A
D
---
V
S
S
L
GADLSDMNSDEP----
Y
----
D
Y
K
F
V
K
W
M
T
K
H
K
K
L
T
A
I
P
V
S
A
F
C
D
SKSKPHF
E
--
K
L
V
R
F
C
F
I
K
K
D
S
T
L
D
A
A
E
E
I
F
R
A
W
-----
3
PsiBlast_PDB
72.82
29%
-108
- C1 -
1GDE
4
?
A:
[9-377]
-------------
L
V
S
A
S
E
I
R
K
L
F
D
I
A
A
G
M
K
------
D
V
I
S
L
G
I
G
E
P
D
----
F
D
T
P
Q
----
H
I
K
E
Y
A
K
E
A
L
D
----
K
G
L
T
H
Y
G
P
N
I
G
L
L
E
L
R
E
A
I
A
E
K
L
K
K
Q
NG
I
E
A
-----
D
P
K
-
T
-
E
-
I
M
V
L
L
G
A
N
Q
A
F
L
M
G
L
S
A
F
L
K
D
-
G
-
E
E
V
L
I
P
T
P
A
F
V
S
Y
A
P
A
V
I
L
A
G
G
--
K
P
V
E
V
P
T
Y
E
E
--
D
------------
E
--
F
R
L
N
V
D
E
L
K
K
Y
V
T
D
K
T
R
A
L
I
I
N
S
P
C
N
P
T
G
A
V
L
T
K
K
D
L
E
E
I
A
D
F
V
V
E
------
H
------
D
L
I
V
I
S
D
E
V
Y
E
H
F
I
Y
D
-
D
A
R
H
Y
S
------
I
A
S
L
----
D
---
G
-
M
F
E
R
T
I
T
V
N
G
F
S
K
T
F
A
M
T
G
W
R
L
G
F
V
A
A
P
S
W
--
I
I
E
R
M
V
K
F
Q
M
Y
N
A
T
-
C
P
V
------
T
F
I
----
Q
------
Y
A
A
A
K
A
L
K
D
E
R
S
W
--------
K
----
A
V
E
E
M
----------
R
----
K
-----------
E
-------------
Y
D
R
R
R
K
L
V
W
K
R
L
N
E
-
M
-
G
L
P
T
V
K
P
K
G
A
F
Y
I
F
-
P
R
-----
I
R
----------------
D
TGLT
S
K
K
F
S
E
L
M
L
K
E
A
R
V
A
V
V
P
G
S
A
F
G
K
-------
A
GE
G
Y
V
R
I
S
Y
A
T
A
Y
E
K
L
E
E
A
M
D
----------
37
HHSearch
71.40
20%
-119
- C1 -
4IX8
2
?
A:
[48-442]
--------------
R
T
L
Q
P
L
N
N
L
T
--
M
K
P
---
S
R
S
T
K
S
N
L
R
L
S
I
G
D
P
T
VDGN
L
K
T
P
D
----
I
V
T
E
A
M
V
D
V
V
R
S
---
G
K
F
N
G
Y
P
P
T
V
G
A
D
N
L
R
Q
V
V
S
T
Y
W
R
R
F
--
C
Q
T
K
S
R
Q
E
A
L
K
-
W
-
E
N
V
I
I
T
S
G
V
S
Q
A
I
V
L
A
L
T
A
L
C
N
E
-
G
-
D
N
I
L
V
C
A
P
S
F
P
H
Y
K
S
V
C
D
S
Y
G
I
--
E
C
R
Y
Y
Y
L
--
D
--
P
SK----------
S
--
W
E
C
D
L
R
A
A
A
G
M
V
D
S
H
T
K
A
F
V
I
I
N
P
S
N
P
C
G
S
N
F
S
R
A
H
V
S
D
I
I
D
F
C
Q
------
Q
H
------
Q
I
P
L
I
S
D
E
I
Y
A
E
M
V
L
N
N
G
----
I
------
F
T
S
V
AD--
F
---
D
-
T
N
V
P
R
L
I
L
G
G
T
A
K
Y
Q
V
C
P
G
W
R
V
G
W
S
I
L
I
D
P
MN
V
A
G
D
--
W
A
V
G
M
-
E
R
-
L
T
Q
-------------
L
------
I
A
G
V
N
S
I
C
-
Q
E
A
I
--------
A
----
R
T
L
L
-----------
K
----
C
P
----------
T
E
C
T
E
H
I
V
T
----
Q
L
E
A
G
A
K
V
Y
A
R
L
L
E
H
-
D
I
G
I
S
M
E
A
P
Q
A
S
M
F
V
M
-
L
K
---
L
N
L
S
YFQDLK----------
S
----
D
M
E
F
Y
E
K
L
L
D
E
E
N
V
Q
V
L
P
G
E
I
F
G
M
-------
S
--
G
F
L
R
A
T
V
S
R
P
S
A
V
L
N
E
A
V
D
R
I
I
E
F
C
E
R
H
-
33
HHSearch
70.92
28%
-109
- C1 -
1O4S
8
AAT_THEMA
A:
[15-388]
------
S
R
R
I
S
E
I
--
P
I
S
K
T
M
E
L
D
A
K
A
K
A
--
L
I
K
K
G
E
D
V
I
N
L
T
A
G
E
P
D
----
F
P
T
P
E
----
P
V
V
E
E
A
V
R
F
L
Q
----
K
G
E
V
K
Y
T
D
P
R
G
I
Y
E
L
R
E
G
I
A
K
R
I
G
E
R
--
Y
K
K
-----
D
I
S
-
P
-
D
Q
V
V
V
T
N
G
A
K
Q
A
L
F
N
A
F
M
A
L
L
D
P
-
G
-
D
E
V
I
V
F
S
P
V
W
V
S
Y
I
P
Q
I
I
L
A
G
G
--
T
V
N
V
V
E
T
--
F
MS
K
------------
N
--
F
Q
P
S
L
E
E
V
E
G
L
L
V
G
K
T
K
A
V
L
I
N
S
P
N
N
P
T
G
V
V
Y
R
R
E
F
L
E
G
L
V
R
L
A
K
------
K
R
------
N
F
Y
I
I
S
D
E
V
Y
D
S
L
V
Y
T
-
D
----
E
------
F
T
S
I
LDV-
S
---
E
-
G
F
D
R
I
V
Y
I
N
G
F
S
K
S
H
S
M
T
G
W
R
V
G
Y
L
I
S
S
E
------
K
--
V
A
T
A
V
-
S
K
-
I
Q
S
--------
H
----
T
------
T
S
C
I
N
T
V
A
-
Q
Y
A
A
--------
L
----
K
A
L
E
-----------
V
----
D
N----------
S
Y
M
----
V
Q
----
T
F
K
E
R
K
N
F
V
V
E
R
L
K
K
-
M
-
G
V
K
F
V
E
P
E
G
A
F
Y
L
F
-
F
K
---
V
R
G
D
----------------
D
-----
V
K
F
C
E
R
L
L
E
E
K
K
V
A
L
V
P
G
S
A
F
L
K
-------
P
--
G
F
V
R
L
S
F
A
T
S
I
E
R
L
T
E
A
L
D
R
I
E
D
F
L
N
S
--
31
HHSearch
70.67
27%
-103
- C1 -
1J32
2
?
A:
[3-387]
-----
L
A
A
R
V
E
S
V
--
S
P
S
M
T
L
I
I
D
A
K
A
K
A
M
--
K
A
E
G
I
D
V
C
S
F
S
A
G
E
P
D
----
F
N
T
P
K
----
H
I
V
E
A
A
K
A
A
L
E
----
Q
G
K
T
R
Y
G
P
A
A
G
E
P
R
L
R
E
A
I
A
Q
K
L
Q
R
D
--
N
G
L
-----
C
Y
G
-
A
-
D
N
I
L
V
T
N
G
G
K
Q
S
I
F
N
L
M
L
A
M
I
E
P
-
G
-
D
E
V
I
I
P
A
P
F
W
V
S
Y
P
E
M
V
K
L
A
E
G
--
T
P
V
I
L
P
T
--
T
VE
T
------------
Q
--
F
K
V
S
P
E
Q
I
R
Q
A
I
T
P
K
T
K
L
L
V
F
N
T
P
S
N
P
T
G
M
V
Y
T
P
D
E
V
R
A
I
A
Q
V
A
V
------
E
A
------
G
L
W
V
L
S
D
E
I
Y
E
K
I
L
Y
D
D
A
----
Q
------
H
L
S
I
GAAS
P
---
E
-
A
Y
E
R
S
V
V
C
S
G
F
A
K
T
Y
A
M
T
G
W
R
V
G
F
L
A
G
P
V
------
P
--
L
V
K
A
A
-
T
K
-
I
Q
G
--------
H
----
S
------
T
S
N
V
C
T
F
A
-
Q
Y
G
A
--------
I
----
A
A
Y
E
-----------
N
SQ
D
C
V
-----------
Q
E
M
----
L
A
----
A
F
A
E
R
R
R
Y
M
L
D
A
L
N
A
-
M
P
G
L
E
C
P
K
P
D
G
A
F
Y
M
F
-
P
S
---
I
A
K
T
GR--------------
S
----
S
L
D
F
C
S
E
L
L
D
Q
H
Q
V
A
T
V
P
G
A
A
F
G
A
-------
D
--
D
C
I
R
L
S
Y
A
T
D
L
D
T
I
K
R
G
M
E
R
L
E
K
F
L
H
G
I
-
4
PsiBlast_PDB
69.92
29%
-109
- C1 -
1GD9
2
?
A:
[9-377]
-------------
L
V
S
A
S
E
I
R
K
L
F
D
I
A
A
G
M
K
------
D
V
I
S
L
G
I
G
E
P
D
----
F
D
T
P
Q
----
H
I
K
E
Y
A
K
E
A
L
D
----
K
G
L
T
H
Y
G
P
N
I
G
L
L
E
L
R
E
A
I
A
E
K
L
K
K
Q
NG
I
E
A
-----
D
P
K
-
T
-
E
-
I
M
V
L
L
G
A
N
Q
A
F
L
M
G
L
S
A
F
L
K
D
-
G
-
E
E
V
L
I
P
T
P
A
F
V
S
Y
A
P
A
V
I
L
A
G
G
--
K
P
V
E
V
P
T
Y
E
E
--
D
------------
E
--
F
R
L
N
V
D
E
L
K
K
Y
V
T
D
K
T
R
A
L
I
I
N
S
P
C
N
P
T
G
A
V
L
T
K
K
D
L
E
E
I
A
D
F
V
V
E
------
H
------
D
L
I
V
I
S
D
E
V
Y
E
H
F
I
Y
D
-
D
A
R
H
Y
S
------
I
A
S
L
----
D
---
G
-
M
F
E
R
T
I
T
V
N
G
F
S
K
T
F
A
M
T
G
W
R
L
G
F
V
A
A
P
S
W
--
I
I
E
R
M
V
K
F
Q
M
Y
N
A
T
-
C
P
V
------
T
F
I
----
Q
------
Y
A
A
A
K
A
L
K
D
E
R
S
W
--------
K
----
A
V
E
E
M
----------
R
----
K
-----------
E
-------------
Y
D
R
R
R
K
L
V
W
K
R
L
N
E
-
M
-
G
L
P
T
V
K
P
K
G
A
F
Y
I
F
-
P
R
-----
I
R
----------------
D
TGLT
S
K
K
F
S
E
L
M
L
K
E
A
R
V
A
V
V
P
G
S
A
F
G
K
-------
A
GE
G
Y
V
R
I
S
Y
A
T
A
Y
E
K
L
E
E
A
M
D
----------
5
PsiBlast_PDB
69.64
28%
-96
- C1 -
1J32
2
?
A:
[1-374]
M
K
L
A
A
R
V
E
S
V
S
P
S
M
T
L
------
I
I
D
A
K
A
K
A
M
K
A
E
G
I
D
-
V
C
S
F
S
A
G
E
P
D
----
F
N
T
P
K
----
H
I
V
E
A
A
K
A
A
L
E
----
Q
G
K
T
R
Y
G
P
A
A
G
E
P
R
L
R
E
A
I
A
Q
K
L
Q
R
D
--
N
G
L
-----
C
Y
G
-
A
-
D
N
I
L
V
T
N
G
G
K
Q
S
I
F
N
L
M
L
A
M
I
E
P
-
G
-
D
E
V
I
I
P
A
P
F
W
V
S
Y
P
E
M
V
K
L
A
E
G
--
T
P
V
I
L
P
T
--
T
VE
T
------------
Q
--
F
K
V
S
P
E
Q
I
R
Q
A
I
T
P
K
T
K
L
L
V
F
N
T
P
S
N
P
T
G
M
V
Y
T
P
D
E
V
R
A
I
A
Q
V
A
V
E
------
A
------
G
L
W
V
L
S
D
E
I
Y
E
K
I
L
Y
D
-
D
----
A
Q
H
L
S
IG
A
A
S
P
--------
E
-
A
Y
E
R
S
V
V
C
S
G
F
A
K
T
Y
A
M
T
G
W
R
V
G
F
L
A
G
P
V
P
--
L
V
K
A
A
T
K
I
Q
G
H
-
S
T
-
S
N
V
------
C
-
T
F
A
Q
Y
G
------
A
I
A
A
Y
E
N
S
-
Q
D
C
V
--------
Q
----
E
M
-------------------------------------
L
A
----
A
F
A
E
R
R
R
Y
M
L
D
A
L
N
A
M
P
-
G
L
E
C
P
K
P
D
G
A
F
Y
M
F
-
P
S
IA-
K
T
G
R
----------------
S
----
S
L
D
F
C
S
E
L
L
D
Q
H
Q
V
A
T
V
P
G
A
A
F
G
A
-------
D
--
D
C
I
R
L
S
Y
A
T
D
L
D
T
I
K
--------------
7
PsiBlast_PDB
69.14
27%
-106
- C1 -
1XI9
2
?
A:
[39-402]
-------------------------------------
K
V
I
R
L
N
I
G
D
P
V
KFD-
F
Q
P
P
E
----
H
M
K
E
A
Y
C
K
A
I
K
----
E
G
H
N
Y
Y
G
D
S
E
G
L
P
E
L
R
K
A
I
V
E
R
E
K
R
K
--
N
G
V
-----
D
I
T
-
P
-
D
D
V
R
V
T
A
A
V
T
E
A
L
Q
L
I
F
G
A
L
L
D
P
-
G
-
D
E
I
L
V
P
G
P
S
Y
P
P
Y
T
G
L
V
K
F
Y
G
G
--
K
P
V
E
Y
R
T
--
I
--
E
------------
E
ED
W
Q
P
D
I
D
D
I
R
K
K
I
T
D
R
T
K
A
I
A
V
I
N
P
N
N
P
T
G
A
L
Y
D
K
K
T
L
E
E
I
L
N
I
A
G
E
Y
E
------------
I
P
V
I
S
D
E
I
Y
D
L
M
T
Y
E
-
G
----
E
------
H
I
S
P
GS--
L
---
T
-
K
D
V
P
V
I
V
M
N
G
L
S
K
V
Y
F
A
T
G
W
R
L
G
Y
M
Y
F
V
D
P
--
E
N
K
L
S
E
V
R
E
A
I
-
D
R
-
L
A
R
------
I
-
R
----
L
------
C
P
N
T
P
A
Q
F
-
A
-
A
I
--------
A
G
L
T
G
P
M
D
Y
L
----------
K
----
E
-----------
Y
------
M
K
----
K
L
K
E
R
R
D
Y
I
Y
K
R
L
N
E
I
P
-
G
I
S
T
T
K
P
Q
G
A
F
Y
I
F
-
P
K
IEV
G
P
W
K
----------------
N
----
D
K
E
F
V
L
D
V
L
H
N
A
H
V
L
F
V
H
G
S
G
F
G
E
YG-----
A
--
G
H
F
R
A
V
F
L
P
P
I
E
I
L
E
E
A
M
D
R
F
E
K
F
M
K
E
--
2
PsiBlast_PDB
69.04
29%
-102
- C1 -
1O4S
8
AAT_THEMA
A:
[29-380]
-----------------------
L
D
A
K
A
K
A
L
I
K
K
G
E
D
-
V
I
N
L
T
A
G
E
P
D
----
F
P
T
P
E
----
P
V
V
E
E
A
V
R
F
L
Q
----
K
G
E
V
K
Y
T
D
P
R
G
I
Y
E
L
R
E
G
I
A
K
R
I
G
E
R
--
Y
K
K
-----
D
I
S
-
P
-
D
Q
V
V
V
T
N
G
A
K
Q
A
L
F
N
A
F
M
A
L
L
D
P
-
G
-
D
E
V
I
V
F
S
P
V
W
V
S
Y
I
P
Q
I
I
L
A
G
G
T
V
N
V
V
E
T
F
M
--
S
--
K
------------
N
--
F
Q
P
S
L
E
E
V
E
G
L
L
V
G
K
T
K
A
V
L
I
N
S
P
N
N
P
T
G
V
V
Y
R
R
E
F
L
E
G
L
V
R
L
A
K
K
------
R
------
N
F
Y
I
I
S
D
E
V
Y
D
S
L
V
Y
T
-
D
----
E
------
F
T
S
I
----
L
DVS
E
-
G
F
D
R
I
V
Y
I
N
G
F
S
K
S
H
S
M
T
G
W
R
V
G
Y
L
I
S
S
E
K
--
V
A
T
A
V
S
K
I
Q
S
H
-
T
T
S
C
I
N
------
T
-
V
----
A
-----------------
Q
Y
--------
A
----
A
L
K
A
L
----------
E
----
V
-----------
D
------
N
S
Y
M
V
Q
T
F
K
E
R
K
N
F
V
V
E
R
L
K
K
-
M
-
G
V
K
F
V
E
P
E
G
A
F
Y
L
F
-
F
K
---
V
R
-
G
----------------
D
----
D
V
K
F
C
E
R
L
L
E
E
K
K
V
A
L
V
P
G
S
A
F
L
K
-------
P
--
G
F
V
R
L
S
F
A
T
S
I
E
R
L
T
E
A
L
D
----------
8
PsiBlast_PDB
68.40
27%
-97
- C1 -
1GCK
4
AAT_THET8
A:
[1-378]
--
M
R
G
L
S
R
R
V
Q
A
M
--
K
P
S
A
T
V
A
V
N
A
K
A
L
E
L
R
R
Q
-
G
V
D
L
V
-
A
L
T
A
G
E
P
D
----
F
D
T
P
E
----
H
V
K
E
A
A
R
R
A
L
A
----
Q
G
K
T
K
Y
A
P
P
A
G
I
P
E
L
R
E
A
L
A
E
K
F
R
R
E
--
N
G
L
-----
S
V
T
-
P
-
E
E
T
I
V
T
V
G
G
S
Q
A
L
F
N
L
F
Q
A
I
L
D
P
-
G
-
D
E
V
I
V
L
S
P
Y
W
V
S
Y
P
E
M
V
R
F
A
G
G
--
V
V
V
E
V
E
T
--
L
--
P
------------
E
EG
F
V
P
D
P
E
R
V
R
R
A
I
T
P
R
T
K
A
L
V
V
N
S
P
N
N
P
T
G
A
V
Y
P
K
E
V
L
E
A
L
A
R
L
A
V
E
------
H
------
D
F
Y
L
V
S
D
E
I
Y
E
H
L
L
Y
E
-
G
----
E
------
H
F
S
P
----
G
---
R
V
A
P
E
H
T
L
T
V
N
G
A
A
K
A
F
A
M
T
G
W
R
I
G
Y
A
C
--------
G
P
K
E
V
I
K
A
M
-
A
S
-
V
S
R
------
Q
------
S
------
T
T
S
P
D
T
I
A
-
Q
W
A
T
L
E
A
L
T
N
Q
E
A
----
S
R
A
F
V
----------
E
----
M
-----------
A
------
R
E
----
A
Y
R
R
R
R
D
L
L
L
E
G
L
T
A
-
L
-
G
L
K
A
V
R
P
S
G
A
F
Y
V
L
M
D
T
---
S
P
I
A
----------------
P
----
D
E
V
R
A
A
E
R
L
L
E
A
G
V
A
V
V
P
G
T
D
F
A
A
-------
F
--
G
H
V
R
L
S
Y
A
T
S
E
E
N
L
R
K
A
L
E
R
F
--------
47
HHSearch
66.66
23%
-123
- C1 -
4WP0
-
KAT1_HUMAN
A:
[26-421]
----------------------------------
S
E
H
D
V
V
N
L
G
Q
G
F
P
D
----
F
P
P
P
D
----
F
A
V
E
A
F
Q
H
A
V
S
G
D--
F
M
L
N
Q
Y
T
K
T
F
G
Y
P
P
L
T
K
I
L
A
S
F
F
G
E
L
--
L
G
Q
-----
E
I
D
-
P
L
R
N
V
L
V
T
V
G
G
Y
G
A
L
F
T
A
F
Q
A
L
V
D
E
-
G
-
D
E
V
I
I
I
E
P
F
F
D
C
Y
E
P
M
T
M
M
A
G
G
--
R
P
V
F
V
S
L
--
K
--
P
GLGSSS------
N
--
W
Q
L
D
P
M
E
L
A
G
K
F
T
S
R
T
K
A
L
V
L
N
T
P
N
N
P
L
G
K
V
F
S
R
E
E
L
E
L
V
A
S
L
C
Q
------
Q
H
------
D
V
V
C
I
T
D
E
V
Y
Q
W
M
V
Y
D
G
H
----
Q
------
H
I
S
I
ASL-
P
---
G
-
M
W
E
R
T
L
T
I
G
S
A
G
-
T
F
S
A
T
G
W
K
V
G
W
V
L
G
P
D
------
H
--
I
M
K
H
L
-
R
T
-
V
H
Q
--------
N
----
S
------
V
F
H
C
P
T
Q
S
-
Q
A
A
V
--------
A
----
E
S
F
E
-----------
R
----
E
Q
L
L
FRQPSS
Y
F
V
Q
F
----
P
Q
----
A
M
Q
R
C
R
D
H
M
I
R
S
L
Q
S
-
V
-
G
L
K
P
I
I
P
Q
G
S
Y
F
L
I
-
T
D
---
I
S
D
F
K
R
K
MPD
L
P
G
A
V
DEP--
Y
----
D
R
R
F
V
K
W
M
I
K
N
K
G
L
V
A
I
P
V
S
I
F
Y
S
VPHQKHF
D
--
H
Y
I
R
F
C
F
V
K
D
E
A
T
L
Q
A
M
D
E
K
L
R
K
W
K
V
E
--
50
HHSearch
66.54
23%
-124
- C1 -
4WLH
2
KAT1_HUMAN
A:
[26-421]
----------------------------------
S
E
H
D
V
V
N
L
G
Q
G
F
P
D
----
F
P
P
P
D
----
F
A
V
E
A
F
Q
H
A
V
S
G
D--
F
M
L
N
Q
Y
T
K
T
F
G
Y
P
P
L
T
K
I
L
A
S
F
F
G
E
L
--
L
G
Q
-----
E
I
D
-
P
L
R
N
V
L
V
T
V
G
G
Y
G
A
L
F
T
A
F
Q
A
L
V
D
E
-
G
-
D
E
V
I
I
I
E
P
F
F
D
C
Y
E
P
M
T
M
M
A
G
G
--
R
P
V
F
V
S
L
--
K
--
P
ELGSSS------
N
--
W
Q
L
D
P
M
E
L
A
G
K
F
T
S
R
T
K
A
L
V
L
N
T
P
N
N
P
L
G
K
V
F
S
R
E
E
L
E
L
V
A
S
L
C
Q
------
Q
H
------
D
V
V
C
I
T
D
E
V
Y
Q
W
M
V
Y
D
G
H
----
Q
------
H
I
S
I
ASL-
P
---
G
-
M
W
E
R
T
L
T
I
G
S
A
G
-
T
F
S
A
T
G
W
K
V
G
W
V
L
G
P
D
------
H
--
I
M
K
H
L
-
R
T
-
V
H
Q
--------
N
----
S
------
V
F
H
C
P
T
Q
S
-
Q
A
A
V
--------
A
----
E
S
F
E
-----------
R
----
E
Q
L
L
FRQPSS
Y
F
V
Q
F
----
P
Q
----
A
M
Q
R
C
R
D
H
M
I
R
S
L
Q
S
-
V
-
G
L
K
P
I
I
P
Q
G
S
Y
F
L
I
-
T
D
---
I
S
D
F
K
R
K
M
PDLPGAVDEP--
Y
----
D
R
R
F
V
K
W
M
I
K
N
K
G
L
V
A
I
P
V
S
I
F
Y
S
VPHQKHF
D
--
H
Y
I
R
F
C
F
V
K
D
E
A
T
L
Q
A
M
D
E
K
L
R
K
W
K
V
E
--
10
PsiBlast_PDB
66.00
26%
-98
- C1 -
1B5O
3
AAT_THET8
A:
[1-378]
--
M
R
G
L
S
R
R
V
Q
A
M
--
K
P
S
A
T
V
A
V
N
A
K
A
L
E
L
R
R
Q
-
G
V
D
L
V
-
A
L
T
A
G
E
P
D
----
F
D
T
P
E
----
H
V
K
E
A
A
R
R
A
L
A
----
Q
G
K
T
K
Y
A
P
P
A
G
I
P
E
L
R
E
A
L
A
E
K
F
R
R
E
--
N
G
L
-----
S
V
T
-
P
-
E
E
T
I
V
T
V
G
G
S
Q
A
L
F
N
L
F
Q
A
I
L
D
P
-
G
-
D
E
V
I
V
L
S
P
Y
W
V
S
Y
P
E
M
V
R
F
A
G
G
--
V
V
V
E
V
E
T
--
L
--
P
------------
E
EG
F
V
P
D
P
E
R
V
R
R
A
I
T
P
R
T
K
A
L
V
V
N
S
P
N
N
P
T
G
A
V
Y
P
K
E
V
L
E
A
L
A
R
L
A
V
E
------
H
------
D
F
Y
L
V
S
D
E
I
Y
E
H
L
L
Y
E
-
G
----
E
------
H
F
S
P
----
G
---
R
V
A
P
E
H
T
L
T
V
N
G
A
A
K
A
F
A
M
T
G
W
R
I
G
Y
----
A
C
--
G
P
K
E
V
I
K
A
M
A
S
-
V
S
-
S
Q
S
------
T
-
T
----
S
PD
T
I
A
Q
W
A
T
L
E
A
L
T
-
N
Q
E
A
--------
S
----
R
A
-
F
V
----------
E
----
M
-----------
A
------
R
E
----
A
Y
R
R
R
R
D
L
L
L
E
G
L
T
A
-
L
-
G
L
K
A
V
R
P
S
G
A
F
Y
V
L
M
D
T
---
S
P
I
A
----------------
P
----
D
E
V
R
A
A
E
R
L
L
E
A
G
V
A
V
V
P
G
T
D
F
A
A
-------
F
--
G
H
V
R
L
S
Y
A
T
S
E
E
N
L
R
K
A
L
E
R
F
--------
36
HHSearch
65.61
21%
-117
- C1 -
3B46
-
BNA3_YEAST
A:
[53-443]
-----------------------------------
G
R
E
L
I
N
L
G
Q
G
F
F
S
----
Y
S
P
P
Q
----
F
A
I
K
E
A
Q
K
A
L
D
I---
P
M
V
N
Q
Y
S
P
T
R
G
R
P
S
L
I
N
S
L
I
K
L
Y
S
P
I
--
Y
N
T
-----
E
L
K
-
A
-
E
N
V
T
V
T
T
G
A
N
E
G
I
L
S
C
L
M
G
L
L
N
A
-
G
-
D
E
V
I
V
F
E
P
F
F
D
Q
Y
I
P
N
I
E
L
C
G
G
--
K
V
V
Y
V
P
I
--
N
--
P
PKELDQRNTRGE
E
--
W
T
I
D
F
E
Q
F
E
K
A
I
T
S
K
T
K
A
V
I
I
N
T
P
H
N
P
I
G
K
V
F
T
R
E
E
L
T
T
L
G
N
I
C
V
------
K
H
------
N
V
V
I
I
S
D
E
V
Y
E
H
L
Y
F
T
-
D
----
S
------
F
T
R
I
ATLS
P
---
E
-
I
G
Q
L
T
L
T
V
G
S
A
G
K
S
F
A
A
T
G
W
R
I
G
W
V
L
S
L
N
A
-----
E
--
L
L
S
Y
A
-
A
K
-
A
H
T
--------
R
----
I
------
C
F
A
S
P
S
P
L
-
Q
E
A
C
--------
A
----
N
S
I
N
-----------
D
----
A
L
K
I
G
Y
F
-----
E
K
M
----
R
Q
----
E
Y
I
N
K
F
K
I
F
T
S
I
F
D
E
-
L
-
G
L
P
Y
T
A
P
E
G
T
Y
F
V
L
-
V
D
---
F
S
K
V
KIPEDYPYPEEILNK
G
K
----
D
F
R
I
S
H
W
L
I
N
E
L
G
V
V
A
I
P
P
T
E
F
Y
I
KEHEKAA
E
--
N
L
L
R
F
A
V
C
K
D
D
A
Y
L
E
N
A
V
E
R
L
K
L
L
K
D
Y
--
16
PsiBlast_PDB
65.45
26%
-99
- C1 -
1BJW
1
AAT_THET8
A:
[1-378]
--
M
R
G
L
S
R
R
V
Q
A
M
--
K
P
S
A
T
V
A
V
N
A
K
A
L
E
L
R
R
Q
-
G
V
D
L
V
-
A
L
T
A
G
E
P
D
----
F
D
T
P
E
----
H
V
K
E
A
A
R
R
A
L
A
----
Q
G
K
T
K
Y
A
P
P
A
G
I
P
E
L
R
E
A
L
A
E
K
F
R
R
E
--
N
G
L
-----
S
V
T
-
P
-
E
E
T
I
V
T
V
G
G
K
Q
A
L
F
N
L
F
Q
A
I
L
D
P
-
G
-
D
E
V
I
V
L
S
P
Y
W
V
S
Y
P
E
M
V
R
F
A
G
G
--
V
V
V
E
V
E
T
--
L
--
P
------------
E
EG
F
V
P
D
P
E
R
V
R
R
A
I
T
P
R
T
K
A
L
V
V
N
S
P
N
N
P
T
G
A
V
Y
P
K
E
V
L
E
A
L
A
R
L
A
V
E
------
H
------
D
F
Y
L
V
S
D
E
I
Y
E
H
L
L
Y
E
-
G
----
E
------
H
F
S
P
----
G
---
R
V
A
P
E
H
T
L
T
V
N
G
A
A
K
A
F
A
M
T
G
W
R
I
G
Y
----
A
C
--
G
P
K
E
V
I
K
A
M
A
S
-
V
S
-
S
Q
S
------
T
-
T
----
S
P
D
T
I
A
Q
W
A
T
L
E
A
L
T
-
N
Q
E
A
--------
S
----
R
A
-
F
V
----------
E
----
M
-----------
A
------
R
E
----
A
Y
R
R
R
R
D
L
L
L
E
G
L
T
A
-
L
-
G
L
K
A
V
R
P
S
G
A
F
Y
V
L
M
D
T
---
S
P
I
A
----------------
P
----
D
E
V
R
A
A
E
R
L
L
E
A
G
V
A
V
V
P
G
T
D
F
A
A
-------
F
--
G
H
V
R
L
S
Y
A
T
S
E
E
N
L
R
K
A
L
E
R
F
--------
46
HHSearch
65.37
26%
-120
- C1 -
1U08
2
YBDL_ECOLI
A:
[30-385]
------------------------------------
H
Q
A
I
N
L
S
Q
G
F
P
D
----
F
D
G
P
R
----
Y
L
Q
E
R
L
A
H
H
V
A
----
Q
G
A
N
Q
Y
A
P
M
T
G
V
Q
A
L
R
E
A
I
A
Q
K
T
E
R
L
--
Y
G
Y
-----
Q
P
D
A
D
-
S
D
I
T
V
T
A
G
A
T
E
A
L
Y
A
A
I
T
A
L
V
R
N
-
G
-
D
E
V
I
C
F
D
P
S
Y
D
S
Y
A
P
A
I
A
L
S
G
G
--
I
V
K
R
M
A
L
--
Q
P
-
P
------------
H
--
F
R
V
D
W
Q
E
F
A
A
L
L
S
E
R
T
R
L
V
I
L
N
T
P
H
N
P
S
A
T
V
W
Q
Q
A
D
F
A
A
L
W
Q
A
I
A
------
G
H
------
E
I
F
V
I
S
D
E
V
Y
E
H
I
N
F
S
Q
Q
----
G
------
H
A
S
V
LAH-
P
---
Q
-
L
R
E
R
A
V
A
V
S
S
F
G
K
T
Y
H
M
T
G
W
K
V
G
Y
C
V
A
P
A
------
P
--
I
S
A
E
I
-
R
K
-
V
H
Q
--------
Y
----
L
------
T
F
S
V
N
T
P
A
-
Q
L
A
L
--------
A
----
D
M
L
R
-----------
A
----
E
-----------
P
EHYLA
L
P
D
----
F
Y
R
Q
K
R
D
I
L
V
N
A
L
N
E
-
S
-
R
L
E
I
L
P
C
E
G
T
Y
F
L
L
-
V
D
---
Y
S
A
V
STL-------------
D
----
D
V
E
F
C
Q
W
L
T
Q
E
H
G
V
A
A
I
P
L
S
V
F
C
A
DPFP---
H
--
K
L
I
R
L
C
F
A
K
K
E
S
T
L
L
A
A
A
E
R
L
R
Q
------