@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : bsu10880: (2016-06-17 )
MTLSQWQPSRKSDVPLHRQIEQYMKDKILHGEWAVGTKIPSQRTLADMFQVNRSTVTAAIDELTSQGLLEGRKGGGTKVVNSTWSVLTAEPPLDWSDYVRSGIHRANSSIIQAINQNEPRADIIRLGTGELSPDLVPADTIGRMFQQINPGVLSLGYEQPKGNRQLREAVADHLKGKKIHVSPSAILIVSGALQALQLISIGLLKRDSVILTEKPSYLQSLHVFQSAGMRLRGLPMDDEGVKAGLVSSNRKQYGGQLLYTIPSFHNPTGTVMSEQRRKEIISLSKKEQMPIIEDDAYGDLWFEEKPPQPLKAMDHEGNILYLGAFSKTVSPGLRIGWLAGPEPVIERLADIKMQTDYGSSGLSQWAAAEWLSQGYYEEHLTWVRRKLKERRDAAVHFLERYAGDIATWRIPAGGFYIWVTFHKNLPVSRFFYELLKRQVLVNPGYIYDGEDRNSIRLSYSYASLGDLETGIKAAAETARRLMMS
Atome Classification :
(20 SA)
.........10........20........30........40........50........60........70........80........90........100.......110.......120.......130.......140......---.-150.--......160.......170....-.-..180-.......190.......200.......210.......220.......230.......240.......----250-----....-----...260.......270.......280.......290.......300.......310...---..---..320.......330.......340.......350.......360.......370.....-.-.380.......390.......400.-......410.......420.......430...-...-.440..--.....450.-........460.......470.......480..
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MTLSQWQPSRKSDV
P
L
H
R
Q
I
E
Q
Y
M
K
DKILHGEWAVGTKIPS
Q
R
T
L
A
D
M
F
Q
VN
R
S
T
V
T
A
A
I
D
E
L
T
S
Q
G
L
LEGRKGGG
T
K
V
V
N
S
T
W
S
V
L
TAEPPL
D
W
S
D
Y
V
R
S
G
I
H
RA
N
S
S
I
I
Q
A
I
NQNEPRA
D
I
I
R
LGTGELSPDLV
P
A
D
T
I
G
R
M
F
Q
QI---N-P
G
V
L--SLGYEQPKG
N
R
Q
L
R
E
A
V
A
D
HLKG-
K
-
K
I
H
VS-P
S
A
I
L
I
V
S
G
A
L
Q
A
L
Q
L
I
S
I
G
LLKRD
S
V
I
LTEK
P
S
Y
L
Q
S
L
H
V
F
Q
SAG
M
R
LRGLPMDDEGVKAGLVSSN----
R
K
Q
-----YG
G
Q
-----
L
L
Y
T
IPSFHNPT
G
T
V
M
S
E
Q
R
R
K
E
I
I
S
LSKKEQMPIIEDDAYGDLWFEEKPPQ
P
L
K
AMDH---EG---
N
I
L
Y
L
GAFSKTVSPG
L
R
I
G
WLAG
P
E
P
V
I
E
R
L
A
D
I
K
M
QTDYGSS
G
L
S
Q
W
A
A
A
E
W
L
S
Q
G
Y
Y
E
-
E
-
H
L
T
W
V
R
R
K
L
K
E
R
R
D
A
A
V
H
F
L
E
R
YAG-DI
A
T
W
R
IPAG
G
F
Y
I
W
V
T
F
HKNL
P
V
S
R
F
F
Y
E
L
L
-
K
R
Q
-
V
LVNP
G
--
Y
I
YDGE--D-R
N
S
I
R
L
S
Y
S
YASLG
D
L
E
T
G
I
K
A
A
A
E
T
A
R
R
L
MMS
59
HHSearch
75.99
33%
-92
* C2 *
3AOW
4
?
A:
[74-447]
----------------------------------------------------------------------------------------------------------------------
E
T
S
D
I
I
S
L
A
G
G
L
P
N
P
K
T
F
P
K
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I
I
R
D
I
L
V
E
I
M
--
E
K
Y
A
D
K
--
A
L
Q
Y
G
T
T
K
G
F
T
P
L
R
E
T
L
M
K
W
L
G
K
R
Y
-
G
I
S
Q
--
D
N
D
I
M
I
T
S
G
S
Q
Q
A
L
D
L
I
G
R
V
F
L
N
P
G
D
I
V
V
V
E
A
P
T
Y
L
A
A
L
Q
A
F
N
F
Y
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P
Q
Y
I
Q
I
P
L
D
D
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G
M
K
V
E
I
L
E
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K
----
L
K
E
L
K
S
Q
G
K
K
V
K
-----
V
V
Y
T
V
P
T
F
Q
N
P
A
G
V
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N
E
D
R
R
K
Y
L
L
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L
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D
F
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D
P
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L
R
Y
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G
N
P
E
K
K
I
K
A
L
D
N
---
E
G
---
R
V
I
Y
L
G
T
F
S
K
I
L
A
P
G
F
R
I
G
W
M
V
G
D
P
G
I
I
R
K
M
E
I
A
K
Q
S
T
D
L
C
T
N
V
F
G
Q
V
V
A
W
R
Y
V
D
G
G
Y
L
E
-
K
-
H
I
P
E
I
R
K
F
Y
K
P
R
R
D
A
M
L
E
A
L
E
E
F
M
P
E
G
V
-
K
W
T
K
P
E
G
G
M
F
I
W
V
T
L
P
D
G
I
D
S
K
K
M
L
E
R
A
I
-
K
K
G
-
V
A
Y
V
P
G
--
E
A
F
Y
A
H
RD
V
-
K
N
T
M
R
L
N
F
T
Y
V
D
E
D
K
I
M
E
G
I
K
R
L
A
E
T
I
K
E
E
L
K
-
21
PsiBlast_CBE
75.99
33%
-100
- C2 -
3WX9
7
?
C:
[76-443]
------------------------------------------------------------------------------------------------------------------------
S
D
I
I
S
L
A
G
G
L
P
N
P
K
T
F
P
K
E
I
I
R
D
I
L
V
E
I
---
M
-
E
K
Y
A
DK
A
L
Q
Y
G
T
T
K
G
F
T
P
L
R
E
T
L
M
K
W
L
-
G
-
K
-
R
Y
G
I
S
Q
D
N
D
I
M
I
T
S
G
S
Q
Q
A
L
D
L
I
G
R
V
F
L
N
P
G
D
I
V
V
V
E
A
P
T
Y
L
A
A
L
Q
A
F
N
F
Y
E
P
Q
Y
I
Q
I
P
L
D
D
E
G
M
K
V
E
I
L
E
E
K
----
L
K
E
-----
L
K
S
Q
GKKVK
V
V
Y
T
V
P
T
F
Q
N
P
A
G
V
T
M
N
E
D
R
R
K
Y
L
L
E
L
A
S
E
Y
D
F
I
V
V
E
D
D
P
Y
G
E
L
R
Y
S
G
N
P
E
K
K
I
K
A
L
D
N
---
E
G
---
R
V
I
Y
L
G
T
F
S
K
I
L
A
P
G
F
R
I
G
W
M
V
G
D
P
G
I
I
R
K
M
E
I
A
K
Q
S
T
D
L
C
T
N
V
F
G
Q
V
V
A
W
R
Y
V
D
G
G
Y
L
E
-
K
-
H
I
P
E
I
R
K
F
Y
K
P
R
R
D
A
M
L
E
A
L
E
E
F
M
P
-
E
G
V
K
W
T
K
P
E
G
G
M
F
I
W
V
T
L
P
D
G
I
D
S
K
K
M
L
E
R
A
I
-
K
K
G
-
V
A
Y
V
P
G
E-
A
F
Y
A
H
R
--
D
V
K
N
T
M
R
L
N
F
T
Y
V
D
E
D
K
I
M
E
G
I
K
R
L
A
E
T
I
K
-----
4
PsiBlast_PDB
75.92
33%
-102
- C2 -
3AV7
5
?
A:
[76-443]
------------------------------------------------------------------------------------------------------------------------
S
D
I
I
S
L
A
G
G
L
P
N
P
K
T
F
P
K
E
I
I
R
D
I
L
V
E
I
---
M
-
E
K
Y
A
D
K
A
L
Q
Y
G
T
T
K
G
F
T
P
L
R
E
T
L
M
K
W
L
-
G
-
K
-
R
Y
G
I
S
Q
D
N
D
I
M
I
T
S
G
S
Q
Q
A
L
D
L
I
G
R
V
F
L
N
P
G
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I
V
V
V
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A
P
T
Y
L
A
A
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A
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N
F
Y
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P
Q
Y
I
Q
I
P
L
D
D
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M
K
V
E
I
L
E
E
K
----
L
K
E
-----
L
K
S
Q
GKKVK
V
V
Y
T
V
P
T
F
Q
N
P
A
G
V
T
M
N
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D
R
R
K
Y
L
L
E
L
A
S
E
Y
D
F
I
V
V
E
D
D
P
Y
G
E
L
R
Y
S
G
N
P
E
K
K
I
K
A
L
D
N
---
E
G
---
R
V
I
Y
L
G
T
F
S
K
I
L
A
P
G
F
R
I
G
W
M
V
G
D
P
G
I
I
R
K
M
E
I
A
K
Q
S
T
D
L
C
T
N
V
F
G
Q
V
V
A
W
R
Y
V
D
G
G
Y
L
E
-
K
-
H
I
P
E
I
R
K
F
Y
K
P
R
R
D
A
M
L
E
A
L
E
E
F
M
P
-
E
G
V
K
W
T
K
P
E
G
G
M
F
I
W
V
T
L
P
D
G
I
D
S
K
K
M
L
E
R
A
I
-
K
K
G
-
V
A
Y
V
P
G
E-
A
F
Y
A
H
R
--
D
V
K
N
T
M
R
L
N
F
T
Y
V
D
E
D
K
I
M
E
G
I
K
R
L
A
E
T
I
K
-----
8
PsiBlast_PDB
75.34
28%
-97
- C2 -
1WST
1
?
A:
[13-412]
--------------------------------------------------------------------------------------------
I
N
F
D
S
F
F
S
E
K
A
M
L
M
K
A
S
E
V
R
E
L
L
K
L
V
E
T
S
D
V
I
S
L
A
G
G
L
P
A
P
E
T
F
P
V
E
T
I
K
K
I
A
V
E
V
L
E
-
E
-
H
A
D
K
--
A
L
Q
Y
G
T
T
K
G
F
T
P
L
R
L
A
L
A
R
W
M
E
K
-
R
Y
D
I
P
M
S
-
K
V
E
I
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T
V
A
G
S
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Q
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L
D
L
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G
R
V
F
L
N
P
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D
P
I
V
V
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A
P
T
Y
L
A
A
I
Q
A
F
K
Y
Y
D
P
E
F
I
S
I
P
L
D
D
K
G
M
R
V
D
L
L
E
E
K
L
E
E
L
R
K
Q
G----
K
R
V
K
-----
I
V
Y
T
V
S
T
F
Q
N
P
A
G
V
T
M
S
V
D
R
R
K
K
L
L
E
L
A
N
E
Y
D
F
L
I
V
E
D
G
P
Y
S
E
L
R
Y
S
G
E
P
T
P
P
I
K
H
F
D
D
---
Y
G
---
R
V
I
Y
L
G
T
F
S
K
I
L
A
P
G
F
R
I
G
W
V
A
A
H
P
H
L
I
R
K
M
E
I
A
K
Q
S
I
D
L
C
T
N
T
F
G
Q
A
I
A
W
K
Y
V
E
N
G
Y
L
D
-
E
-
H
I
P
K
I
I
E
F
Y
K
P
R
R
D
A
M
L
E
A
L
E
E
Y
M
P
-
E
G
V
E
W
T
K
P
E
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G
M
F
V
R
V
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L
P
E
G
I
D
T
K
L
M
M
E
R
A
V
-
A
K
G
-
V
A
Y
V
P
G
EA
F
F
V
H
R
D
--
K
-
K
N
T
M
R
L
N
F
T
Y
V
P
E
E
T
I
R
E
G
V
R
R
L
A
E
T
I
K
E
E
M
--
22
PsiBlast_CBE
75.06
33%
-99
- C2 -
3AV7
4
?
C:
[76-443]
------------------------------------------------------------------------------------------------------------------------
S
D
I
I
S
L
A
G
G
L
P
N
P
K
T
F
P
K
E
I
I
R
D
I
L
V
E
I
---
M
-
E
K
Y
A
DK
A
L
Q
Y
G
T
T
K
G
F
T
P
L
R
E
T
L
M
K
W
L
-
G
-
K
-
R
Y
G
I
S
Q
D
N
D
I
M
I
T
S
G
S
Q
Q
A
L
D
L
I
G
R
V
F
L
N
P
G
D
I
V
V
V
E
A
P
T
Y
L
A
A
L
Q
A
F
N
F
Y
E
P
Q
Y
I
Q
I
P
L
D
D
E
G
M
K
V
E
I
L
E
E
K
----
L
K
E
-----
L
K
S
Q
GKKVK
V
V
Y
T
V
P
T
F
Q
N
P
A
G
V
T
M
N
E
D
R
R
K
Y
L
L
E
L
A
S
E
Y
D
F
I
V
V
E
D
D
P
Y
G
E
L
R
Y
S
G
N
P
E
K
K
I
K
A
L
D
N
---
E
G
---
R
V
I
Y
L
G
T
F
S
K
I
L
A
P
G
F
R
I
G
W
M
V
G
D
P
G
I
I
R
K
M
E
I
A
K
Q
S
T
D
L
C
T
N
V
F
G
Q
V
V
A
W
R
Y
V
D
G
G
Y
L
E
-
K
-
H
I
P
E
I
R
K
F
Y
K
P
R
R
D
A
M
L
E
A
L
E
E
F
M
P
-
E
G
V
K
W
T
K
P
E
G
G
M
F
I
W
V
T
L
P
D
G
I
D
S
K
K
M
L
E
R
A
I
-
K
K
G
-
V
A
Y
V
P
G
E-
A
F
Y
A
H
R
--
D
V
K
N
T
M
R
L
N
F
T
Y
V
D
E
D
K
I
M
E
G
I
K
R
L
A
E
T
I
K
-----
25
PsiBlast_CBE
74.81
33%
-100
- C2 -
3AOV
2
?
C:
[76-443]
------------------------------------------------------------------------------------------------------------------------
S
D
I
I
S
L
A
G
G
L
P
N
P
K
T
F
P
K
E
I
I
R
D
I
L
V
E
I
---
M
-
E
K
Y
A
DK
A
L
Q
Y
G
T
T
K
G
F
T
P
L
R
E
T
L
M
K
W
L
-
G
-
K
-
R
Y
G
I
S
Q
D
N
D
I
M
I
T
S
G
S
Q
Q
A
L
D
L
I
G
R
V
F
L
N
P
G
D
I
V
V
V
E
A
P
T
Y
L
A
A
L
Q
A
F
N
F
Y
E
P
Q
Y
I
Q
I
P
L
D
D
E
G
M
K
V
E
I
L
E
E
K
----
L
K
E
-----
L
K
S
Q
GKKVK
V
V
Y
T
V
P
T
F
Q
N
P
A
G
V
T
M
N
E
D
R
R
K
Y
L
L
E
L
A
S
E
Y
D
F
I
V
V
E
D
D
P
Y
G
E
L
R
Y
S
G
N
P
E
K
K
I
K
A
L
D
N
---
E
G
---
R
V
I
Y
L
G
T
F
S
K
I
L
A
P
G
F
R
I
G
W
M
V
G
D
P
G
I
I
R
K
M
E
I
A
K
Q
S
T
D
L
C
T
N
V
F
G
Q
V
V
A
W
R
Y
V
D
G
G
Y
L
E
-
K
-
H
I
P
E
I
R
K
F
Y
K
P
R
R
D
A
M
L
E
A
L
E
E
F
M
P
-
E
G
V
K
W
T
K
P
E
G
G
M
F
I
W
V
T
L
P
D
G
I
D
S
K
K
M
L
E
R
A
I
-
K
K
G
-
V
A
Y
V
P
G
E-
A
F
Y
A
H
R
--
D
V
K
N
T
M
R
L
N
F
T
Y
V
D
E
D
K
I
M
E
G
I
K
R
L
A
E
T
I
K
-----
1
PsiBlast_PDB
74.64
33%
-100
- C2 -
3AOV
2
?
A:
[76-443]
------------------------------------------------------------------------------------------------------------------------
S
D
I
I
S
L
A
G
G
L
P
N
P
K
T
F
P
K
E
I
I
R
D
I
L
V
E
I
---
M
-
E
K
Y
A
D
K
A
L
Q
Y
G
T
T
K
G
F
T
P
L
R
E
T
L
M
K
W
L
-
G
-
K
-
R
Y
G
I
S
Q
D
N
D
I
M
I
T
S
G
S
Q
Q
A
L
D
L
I
G
R
V
F
L
N
P
G
D
I
V
V
V
E
A
P
T
Y
L
A
A
L
Q
A
F
N
F
Y
E
P
Q
Y
I
Q
I
P
L
D
D
E
G
M
K
V
E
I
L
E
E
K
----
L
K
E
-----
L
K
S
Q
GKKVK
V
V
Y
T
V
P
T
F
Q
N
P
A
G
V
T
M
N
E
D
R
R
K
Y
L
L
E
L
A
S
E
Y
D
F
I
V
V
E
D
D
P
Y
G
E
L
R
Y
S
G
N
P
E
K
K
I
K
A
L
D
N
---
E
G
---
R
V
I
Y
L
G
T
F
S
K
I
L
A
P
G
F
R
I
G
W
M
V
G
D
P
G
I
I
R
K
M
E
I
A
K
Q
S
T
D
L
C
T
N
V
F
G
Q
V
V
A
W
R
Y
V
D
G
G
Y
L
E
-
K
-
H
I
P
E
I
R
K
F
Y
K
P
R
R
D
A
M
L
E
A
L
E
E
F
M
P
-
E
G
V
K
W
T
K
P
E
G
G
M
F
I
W
V
T
L
P
D
G
I
D
S
K
K
M
L
E
R
A
I
-
K
K
G
-
V
A
Y
V
P
G
E-
A
F
Y
A
H
R
--
D
V
K
N
T
M
R
L
N
F
T
Y
V
D
E
D
K
I
M
E
G
I
K
R
L
A
E
T
I
K
-----
6
PsiBlast_PDB
74.63
33%
-103
- C2 -
1X0M
-
?
A:
[56-423]
------------------------------------------------------------------------------------------------------------------------
S
D
I
I
S
L
A
G
G
L
P
N
P
K
T
F
P
K
E
I
I
R
D
I
L
V
E
I
---
M
-
E
K
Y
A
D
K
A
L
Q
Y
G
T
T
K
G
F
T
P
L
R
E
T
L
M
K
W
L
-
G
-
K
-
R
Y
G
I
S
Q
D
N
D
I
M
I
T
S
G
S
Q
Q
A
L
D
L
I
G
R
V
F
L
N
P
G
D
I
V
V
V
E
A
P
T
Y
L
A
A
L
Q
A
F
N
F
Y
E
P
Q
Y
I
Q
I
P
L
D
D
E
G
M
K
V
E
I
L
E
E
K
----
L
K
E
-----
L
K
S
Q
GKKVK
V
V
Y
T
V
P
T
F
Q
N
P
A
G
V
T
M
N
E
D
R
R
K
Y
L
L
E
L
A
S
E
Y
D
F
I
V
V
E
D
D
P
Y
G
E
L
R
Y
S
G
N
P
E
K
K
I
K
A
L
D
N
---
E
G
---
R
V
I
Y
L
G
T
F
S
K
I
L
A
P
G
F
R
I
G
W
M
V
G
D
P
G
I
I
R
K
M
E
I
A
K
Q
S
T
D
L
C
T
N
V
F
G
Q
V
V
A
W
R
Y
V
D
G
G
Y
L
E
-
K
-
H
I
P
E
I
R
K
F
Y
K
P
R
R
D
A
M
L
E
A
L
E
E
F
M
P
-
E
G
V
K
W
T
K
P
E
G
G
M
F
I
W
V
T
L
P
D
G
I
D
S
K
K
M
L
E
R
A
I
-
K
K
G
-
V
A
Y
V
P
G
E-
A
F
Y
A
H
R
--
D
V
K
N
T
M
R
L
N
F
T
Y
V
D
E
D
K
I
M
E
G
I
K
R
L
A
E
T
I
K
-----
3
PsiBlast_PDB
74.53
33%
-99
- C2 -
3ATH
5
?
A:
[76-443]
------------------------------------------------------------------------------------------------------------------------
S
D
I
I
S
L
A
G
G
L
P
N
P
K
T
F
P
K
E
I
I
R
D
I
L
V
E
I
---
M
-
E
K
Y
A
D
K
A
L
Q
Y
G
T
T
K
G
F
T
P
L
R
E
T
L
M
K
W
L
-
G
-
K
-
R
Y
G
I
S
Q
D
N
D
I
M
I
T
S
G
S
Q
Q
A
L
D
L
I
G
R
V
F
L
N
P
G
D
I
V
V
V
E
A
P
T
Y
L
A
A
L
Q
A
F
N
F
Y
E
P
Q
Y
I
Q
I
P
L
D
D
E
G
M
K
V
E
I
L
E
E
K
----
L
K
E
-----
L
K
S
Q
GKKVK
V
V
Y
T
V
P
T
F
Q
N
P
A
G
V
T
M
N
E
D
R
R
K
Y
L
L
E
L
A
S
E
Y
D
F
I
V
V
E
D
D
P
Y
G
E
L
R
Y
S
G
N
P
E
K
K
I
K
A
L
D
N
---
E
G
---
R
V
I
Y
L
G
T
F
S
K
I
L
A
P
G
F
R
I
G
W
M
V
G
D
P
G
I
I
R
K
M
E
I
A
K
Q
S
T
D
L
C
T
N
V
F
G
Q
V
V
A
W
R
Y
V
D
G
G
Y
L
E
-
K
-
H
I
P
E
I
R
K
F
Y
K
P
R
R
D
A
M
L
E
A
L
E
E
F
M
P
-
E
G
V
K
W
T
K
P
E
G
G
M
F
I
W
V
T
L
P
D
G
I
D
S
K
K
M
L
E
R
A
I
-
K
K
G
-
V
A
Y
V
P
G
E-
A
F
Y
A
H
R
--
D
V
K
N
T
M
R
L
N
F
T
Y
V
D
E
D
K
I
M
E
G
I
K
R
L
A
E
T
I
K
-----
2
PsiBlast_PDB
74.26
33%
-99
- C2 -
3AOW
4
?
A:
[76-443]
------------------------------------------------------------------------------------------------------------------------
S
D
I
I
S
L
A
G
G
L
P
N
P
K
T
F
P
K
E
I
I
R
D
I
L
V
E
I
---
M
-
E
K
Y
A
D
K
A
L
Q
Y
G
T
T
K
G
F
T
P
L
R
E
T
L
M
K
W
L
-
G
-
K
-
R
Y
G
I
S
Q
D
N
D
I
M
I
T
S
G
S
Q
Q
A
L
D
L
I
G
R
V
F
L
N
P
G
D
I
V
V
V
E
A
P
T
Y
L
A
A
L
Q
A
F
N
F
Y
E
P
Q
Y
I
Q
I
P
L
D
D
E
G
M
K
V
E
I
L
E
E
K
----
L
K
E
-----
L
K
S
Q
GKKVK
V
V
Y
T
V
P
T
F
Q
N
P
A
G
V
T
M
N
E
D
R
R
K
Y
L
L
E
L
A
S
E
Y
D
F
I
V
V
E
D
D
P
Y
G
E
L
R
Y
S
G
N
P
E
K
K
I
K
A
L
D
N
---
E
G
---
R
V
I
Y
L
G
T
F
S
K
I
L
A
P
G
F
R
I
G
W
M
V
G
D
P
G
I
I
R
K
M
E
I
A
K
Q
S
T
D
L
C
T
N
V
F
G
Q
V
V
A
W
R
Y
V
D
G
G
Y
L
E
-
K
-
H
I
P
E
I
R
K
F
Y
K
P
R
R
D
A
M
L
E
A
L
E
E
F
M
P
-
E
G
V
K
W
T
K
P
E
G
G
M
F
I
W
V
T
L
P
D
G
I
D
S
K
K
M
L
E
R
A
I
-
K
K
G
-
V
A
Y
V
P
G
E-
A
F
Y
A
H
R
--
D
V
K
N
T
M
R
L
N
F
T
Y
V
D
E
D
K
I
M
E
G
I
K
R
L
A
E
T
I
K
-----
5
PsiBlast_PDB
74.05
33%
-100
- C2 -
3WX9
7
?
A:
[76-443]
------------------------------------------------------------------------------------------------------------------------
S
D
I
I
S
L
A
G
G
L
P
N
P
K
T
F
P
K
E
I
I
R
D
I
L
V
E
I
---
M
-
E
K
Y
A
D
K
A
L
Q
Y
G
T
T
K
G
F
T
P
L
R
E
T
L
M
K
W
L
-
G
-
K
-
R
Y
G
I
S
Q
D
N
D
I
M
I
T
S
G
S
Q
Q
A
L
D
L
I
G
R
V
F
L
N
P
G
D
I
V
V
V
E
A
P
T
Y
L
A
A
L
Q
A
F
N
F
Y
E
P
Q
Y
I
Q
I
P
L
D
D
E
G
M
K
V
E
I
L
E
E
K
----
L
K
E
-----
L
K
S
Q
GKKVK
V
V
Y
T
V
P
T
F
Q
N
P
A
G
V
T
M
N
E
D
R
R
K
Y
L
L
E
L
A
S
E
Y
D
F
I
V
V
E
D
D
P
Y
G
E
L
R
Y
S
G
N
P
E
K
K
I
K
A
L
D
N
---
E
G
---
R
V
I
Y
L
G
T
F
S
K
I
L
A
P
G
F
R
I
G
W
M
V
G
D
P
G
I
I
R
K
M
E
I
A
K
Q
S
T
D
L
C
T
N
V
F
G
Q
V
V
A
W
R
Y
V
D
G
G
Y
L
E
-
K
-
H
I
P
E
I
R
K
F
Y
K
P
R
R
D
A
M
L
E
A
L
E
E
F
M
P
-
E
G
V
K
W
T
K
P
E
G
G
M
F
I
W
V
T
L
P
D
G
I
D
S
K
K
M
L
E
R
A
I
-
K
K
G
-
V
A
Y
V
P
G
E-
A
F
Y
A
H
R
--
D
V
K
N
T
M
R
L
N
F
T
Y
V
D
E
D
K
I
M
E
G
I
K
R
L
A
E
T
I
K
-----
23
PsiBlast_CBE
74.00
33%
-100
- C2 -
3ATH
5
?
C:
[76-443]
------------------------------------------------------------------------------------------------------------------------
S
D
I
I
S
L
A
G
G
L
P
N
P
K
T
F
P
K
E
I
I
R
D
I
L
V
E
I
---
M
-
E
K
Y
A
DK
A
L
Q
Y
G
T
T
K
G
F
T
P
L
R
E
T
L
M
K
W
L
-
G
-
K
-
R
Y
G
I
S
Q
D
N
D
I
M
I
T
S
G
S
Q
Q
A
L
D
L
I
G
R
V
F
L
N
P
G
D
I
V
V
V
E
A
P
T
Y
L
A
A
L
Q
A
F
N
F
Y
E
P
Q
Y
I
Q
I
P
L
D
D
E
G
M
K
V
E
I
L
E
E
K
----
L
K
E
-----
L
K
S
Q
GKKVK
V
V
Y
T
V
P
T
F
Q
N
P
A
G
V
T
M
N
E
D
R
R
K
Y
L
L
E
L
A
S
E
Y
D
F
I
V
V
E
D
D
P
Y
G
E
L
R
Y
S
G
N
P
E
K
K
I
K
A
L
D
N
---
E
G
---
R
V
I
Y
L
G
T
F
S
K
I
L
A
P
G
F
R
I
G
W
M
V
G
D
P
G
I
I
R
K
M
E
I
A
K
Q
S
T
D
L
C
T
N
V
F
G
Q
V
V
A
W
R
Y
V
D
G
G
Y
L
E
-
K
-
H
I
P
E
I
R
K
F
Y
K
P
R
R
D
A
M
L
E
A
L
E
E
F
M
P
-
E
G
V
K
W
T
K
P
E
G
G
M
F
I
W
V
T
L
P
D
G
I
D
S
K
K
M
L
E
R
A
I
-
K
K
G
-
V
A
Y
V
P
G
E-
A
F
Y
A
H
R
--
D
V
K
N
T
M
R
L
N
F
T
Y
V
D
E
D
K
I
M
E
G
I
K
R
L
A
E
T
I
K
-----
24
PsiBlast_CBE
73.78
33%
-97
- C2 -
3AOW
4
?
C:
[76-443]
------------------------------------------------------------------------------------------------------------------------
S
D
I
I
S
L
A
G
G
L
P
N
P
K
T
F
P
K
E
I
I
R
D
I
L
V
E
I
---
M
-
E
K
Y
A
DK
A
L
Q
Y
G
T
T
K
G
F
T
P
L
R
E
T
L
M
K
W
L
-
G
-
K
-
R
Y
G
I
S
Q
D
N
D
I
M
I
T
S
G
S
Q
Q
A
L
D
L
I
G
R
V
F
L
N
P
G
D
I
V
V
V
E
A
P
T
Y
L
A
A
L
Q
A
F
N
F
Y
E
P
Q
Y
I
Q
I
P
L
D
D
E
G
M
K
V
E
I
L
E
E
K
----
L
K
E
-----
L
K
S
Q
GKKVK
V
V
Y
T
V
P
T
F
Q
N
P
A
G
V
T
M
N
E
D
R
R
K
Y
L
L
E
L
A
S
E
Y
D
F
I
V
V
E
D
D
P
Y
G
E
L
R
Y
S
G
N
P
E
K
K
I
K
A
L
D
N
---
E
G
---
R
V
I
Y
L
G
T
F
S
K
I
L
A
P
G
F
R
I
G
W
M
V
G
D
P
G
I
I
R
K
M
E
I
A
K
Q
S
T
D
L
C
T
N
V
F
G
Q
V
V
A
W
R
Y
V
D
G
G
Y
L
E
-
K
-
H
I
P
E
I
R
K
F
Y
K
P
R
R
D
A
M
L
E
A
L
E
E
F
M
P
-
E
G
V
K
W
T
K
P
E
G
G
M
F
I
W
V
T
L
P
D
G
I
D
S
K
K
M
L
E
R
A
I
-
K
K
G
-
V
A
Y
V
P
G
E-
A
F
Y
A
H
R
--
D
V
K
N
T
M
R
L
N
F
T
Y
V
D
E
D
K
I
M
E
G
I
K
R
L
A
E
T
I
K
-----
62
HHSearch
73.70
31%
-97
- C2 -
2ZC0
4
?
A:
[32-405]
----------------------------------------------------------------------------------------------------------------------
K
G
V
K
L
I
S
L
A
A
G
D
P
D
P
E
L
I
P
R
A
V
L
G
E
I
A
K
E
V
L
--
E
-
K
E
P
K
--
S
V
M
Y
T
P
A
N
G
I
P
E
L
R
E
E
L
A
A
F
L
K
K
Y
D
-
H
L
E
V
S
-
P
E
N
I
V
I
T
I
G
G
T
G
A
L
D
L
L
G
R
V
L
I
D
P
G
D
V
V
I
T
E
N
P
S
Y
I
N
T
L
L
A
F
E
Q
L
G
A
K
I
E
G
V
P
V
D
N
D
G
M
R
V
D
L
L
E
E
K
----
I
K
E
L
K
A
K
G
Q
K
V
K
-----
L
I
Y
T
I
P
T
G
Q
N
P
M
G
V
T
M
S
M
E
R
R
K
A
L
L
E
I
A
S
K
Y
D
L
L
I
I
E
D
T
A
Y
N
F
M
R
Y
E
G
G
D
I
V
P
L
K
A
L
D
N
---
E
G
---
R
V
I
V
A
G
T
L
S
K
V
L
G
T
G
F
R
I
G
W
I
I
A
E
G
E
I
L
K
K
V
L
M
Q
K
Q
P
I
D
F
C
A
P
A
I
S
Q
Y
I
A
L
E
Y
L
K
R
G
Y
F
E
K
Y
-
H
L
E
G
A
L
L
G
Y
K
E
K
R
D
I
M
L
K
A
L
E
N
H
L
P
-
N
A
-
E
F
T
K
P
I
A
G
M
F
V
M
F
F
L
P
E
G
A
D
G
I
S
F
A
N
E
L
M
E
R
E
G
-
V
V
V
V
P
G
--
K
P
F
Y
T
D
ES
G
-
K
N
A
I
R
L
N
F
S
R
P
S
K
E
E
I
P
I
G
I
K
K
L
A
K
L
Y
K
E
K
F
--
7
PsiBlast_PDB
73.42
32%
-100
- C2 -
2ZC0
4
?
A:
[36-399]
--------------------------------------------------------------------------------------------------------------------------
L
I
S
L
A
A
G
D
P
D
P
E
L
I
P
R
A
V
L
G
E
I
A
K
E
V
L
E
K
E
-
P
K
----
S
V
M
Y
T
P
A
N
G
I
P
E
L
R
E
E
L
A
A
F
L
K
K
Y
D
-
H
L
E
V
S
-
P
E
N
I
V
I
T
I
G
G
T
G
A
L
D
L
L
G
R
V
L
I
D
P
G
D
V
V
I
T
E
N
P
S
Y
I
N
T
L
L
A
F
E
Q
L
G
A
K
I
E
G
V
P
V
D
N
D
G
M
R
V
D
L
L
E
E
K
----
I
K
E
-----
L
K
A
K
G
Q
K
V
K
L
I
Y
T
I
P
T
G
Q
N
P
M
G
V
T
M
S
M
E
R
R
K
A
L
L
E
I
A
S
K
Y
D
L
L
I
I
E
D
T
A
Y
N
F
M
R
Y
E
G
G
D
I
V
P
L
K
A
L
D
N
---
E
G
---
R
V
I
V
A
G
T
L
S
K
V
L
G
T
G
F
R
I
G
W
I
I
A
E
G
E
I
L
K
K
V
L
M
Q
K
Q
P
I
D
F
C
A
P
A
I
S
Q
Y
I
A
L
E
Y
L
K
R
G
Y
F
E
-
K
Y
H
L
E
G
A
L
L
G
Y
K
E
K
R
D
I
M
L
K
A
L
E
N
H
L
P
-
N
-
A
E
F
T
K
P
I
A
G
M
F
V
M
F
F
L
P
E
G
A
D
G
I
S
F
A
N
E
L
M
-
E
R
E
G
V
V
V
V
P
G
KP
F
Y
T
D
E
S
--
G
-
K
N
A
I
R
L
N
F
S
R
P
S
K
E
E
I
P
I
G
I
K
K
L
A
K
--------
27
PsiBlast_CBE
73.39
32%
-102
- C2 -
2ZC0
4
?
C:
[36-399]
--------------------------------------------------------------------------------------------------------------------------
L
I
S
L
A
A
G
D
P
D
P
E
L
I
P
R
A
V
L
G
E
I
A
K
E
V
LEK
E
-
P
K
----
S
V
M
Y
T
P
A
N
G
I
P
E
L
R
E
E
L
A
A
F
L
K
K
Y
D
-
H
L
E
V
S
-
P
E
N
I
V
I
T
I
G
G
T
G
A
L
D
L
L
G
R
V
L
I
D
P
G
D
V
V
I
T
E
N
P
S
Y
I
N
T
L
L
A
F
E
Q
L
G
A
K
I
E
G
V
P
V
D
N
D
G
M
R
V
D
L
L
E
E
K
----
I
K
E
-----
L
K
A
K
GQKVK
L
I
Y
T
I
P
T
G
Q
N
P
M
G
V
T
M
S
M
E
R
R
K
A
L
L
E
I
A
S
K
Y
D
L
L
I
I
E
D
T
A
Y
N
F
M
R
Y
E
G
G
D
I
V
P
L
K
A
L
D
N
---
E
G
---
R
V
I
V
A
G
T
L
S
K
V
L
G
T
G
F
R
I
G
W
I
I
A
E
G
E
I
L
K
K
V
L
M
Q
K
Q
P
I
D
F
C
A
P
A
I
S
Q
Y
I
A
L
E
Y
L
K
R
G
Y
F
E
-
K
Y
H
L
E
G
A
L
L
G
Y
K
E
K
R
D
I
M
L
K
A
L
E
N
H
L
P
-
N
-
A
E
F
T
K
P
I
A
G
M
F
V
M
F
F
L
P
E
G
A
D
G
I
S
F
A
N
E
L
M
-
E
R
E
G
V
V
V
V
P
G
KP
F
Y
T
D
E
S
--
G
-
K
N
A
I
R
L
N
F
S
R
P
S
K
E
E
I
P
I
G
I
K
K
L
A
K
--------
65
HHSearch
72.75
30%
-96
- C2 -
2ZYJ
2
LYSN_THET2
A:
[30-395]
----------------------------------------------------------------------------------------------------------------------
Q
R
P
G
I
L
S
F
A
G
G
L
P
A
P
E
L
F
P
K
E
E
A
A
E
A
A
A
R
I
L
--
R
E
K
G
E
V
--
A
L
Q
Y
S
P
T
E
G
Y
A
P
L
R
A
F
V
A
E
W
I
-----
G
--
V
R
-
P
E
E
V
L
I
T
T
G
S
Q
Q
A
L
D
L
V
G
K
V
F
L
D
E
G
S
P
V
L
L
E
A
P
S
Y
M
G
A
I
Q
A
F
R
L
Q
G
P
R
F
L
T
V
P
A
G
E
E
G
P
D
L
D
A
L
E
E
V
----
L
K
R
-----
E
R
P
R
-----
F
L
Y
L
I
P
S
F
Q
N
P
T
G
G
L
T
P
L
P
A
R
K
R
L
L
Q
M
V
M
E
R
G
L
V
V
V
E
D
D
A
Y
R
E
L
Y
F
G
E
A
R
L
P
S
L
F
E
L
A
R
E
A
G
Y
P
---
G
V
I
Y
L
G
S
F
S
K
V
L
S
P
G
L
R
V
A
F
A
V
A
H
P
E
A
L
Q
K
L
V
Q
A
K
Q
G
A
D
L
H
T
P
M
L
N
Q
M
L
V
H
E
L
L
K
E
G
-
F
S
-
E
-
R
L
E
R
V
R
R
V
Y
R
E
K
A
Q
A
M
L
H
A
L
D
R
E
V
P
K
E
V
-
R
Y
T
R
P
K
G
G
M
F
V
W
M
E
L
P
K
G
L
S
A
E
G
L
F
R
R
A
L
-
E
E
N
-
V
A
F
V
P
G
--
G
P
F
F
A
N
GG
G
-
E
N
T
L
R
L
S
Y
A
T
L
D
R
E
G
I
A
E
G
V
R
R
L
G
R
A
L
K
G
L
L
A
-
26
PsiBlast_CBE
72.21
32%
-101
- C2 -
2ZC0
4
?
D:
[36-399]
--------------------------------------------------------------------------------------------------------------------------
L
I
S
L
A
A
G
D
P
D
P
E
L
I
P
R
A
V
L
G
E
I
A
K
E
V
LEK
E
-
P
K
----
S
V
M
Y
T
P
A
N
G
I
P
E
L
R
E
E
L
A
A
F
L
K
K
Y
D
-
H
L
E
V
S
-
P
E
N
I
V
I
T
I
G
G
T
G
A
L
D
L
L
G
R
V
L
I
D
P
G
D
V
V
I
T
E
N
P
S
Y
I
N
T
L
L
A
F
E
Q
L
G
A
K
I
E
G
V
P
V
D
N
D
G
M
R
V
D
L
L
E
E
K
----
I
K
E
-----
L
K
A
K
GQKVK
L
I
Y
T
I
P
T
G
Q
N
P
M
G
V
T
M
S
M
E
R
R
K
A
L
L
E
I
A
S
K
Y
D
L
L
I
I
E
D
T
A
Y
N
F
M
R
Y
E
G
G
D
I
V
P
L
K
A
L
D
N
---
E
G
---
R
V
I
V
A
G
T
L
S
K
V
L
G
T
G
F
R
I
G
W
I
I
A
E
G
E
I
L
K
K
V
L
M
Q
K
Q
P
I
D
F
C
A
P
A
I
S
Q
Y
I
A
L
E
Y
L
K
R
G
Y
F
E
-
K
Y
H
L
E
G
A
L
L
G
Y
K
E
K
R
D
I
M
L
K
A
L
E
N
H
L
P
-
N
-
A
E
F
T
K
P
I
A
G
M
F
V
M
F
F
L
P
E
G
A
D
G
I
S
F
A
N
E
L
M
-
E
R
E
G
V
V
V
V
P
G
KP
F
Y
T
D
E
S
--
G
-
K
N
A
I
R
L
N
F
S
R
P
S
K
E
E
I
P
I
G
I
K
K
L
A
K
--------
28
PsiBlast_CBE
71.77
32%
-103
- C2 -
2ZC0
4
?
B:
[36-399]
--------------------------------------------------------------------------------------------------------------------------
L
I
S
L
A
A
G
D
P
D
P
E
L
I
P
R
A
V
L
G
E
I
A
K
E
V
LEK
E
-
P
K
----
S
V
M
Y
T
P
A
N
G
I
P
E
L
R
E
E
L
A
A
F
L
K
K
Y
D
-
H
L
E
V
S
-
P
E
N
I
V
I
T
I
G
G
T
G
A
L
D
L
L
G
R
V
L
I
D
P
G
D
V
V
I
T
E
N
P
S
Y
I
N
T
L
L
A
F
E
Q
L
G
A
K
I
E
G
V
P
V
D
N
D
G
M
R
V
D
L
L
E
E
K
----
I
K
E
-----
L
K
A
K
GQKVK
L
I
Y
T
I
P
T
G
Q
N
P
M
G
V
T
M
S
M
E
R
R
K
A
L
L
E
I
A
S
K
Y
D
L
L
I
I
E
D
T
A
Y
N
F
M
R
Y
E
G
G
D
I
V
P
L
K
A
L
D
N
---
E
G
---
R
V
I
V
A
G
T
L
S
K
V
L
G
T
G
F
R
I
G
W
I
I
A
E
G
E
I
L
K
K
V
L
M
Q
K
Q
P
I
D
F
C
A
P
A
I
S
Q
Y
I
A
L
E
Y
L
K
R
G
Y
F
E
-
K
Y
H
L
E
G
A
L
L
G
Y
K
E
K
R
D
I
M
L
K
A
L
E
N
H
L
P
-
N
-
A
E
F
T
K
P
I
A
G
M
F
V
M
F
F
L
P
E
G
A
D
G
I
S
F
A
N
E
L
M
-
E
R
E
G
V
V
V
V
P
G
KP
F
Y
T
D
E
S
--
G
-
K
N
A
I
R
L
N
F
S
R
P
S
K
E
E
I
P
I
G
I
K
K
L
A
K
--------
13
PsiBlast_PDB
71.55
29%
-91
- C2 -
2ZYJ
2
LYSN_THET2
A:
[3-384]
-------------------------------------------------------------------------------------------
P
L
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W
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----
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-----
E
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-----
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---
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--
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------------