@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : bsu12980: (2016-06-20 )
MKIIRIETSRIAVPLTKPFKTALRTVYTAESVIVRITYDSGAVGWGEAPPTLVITGDSMDSIESAIHHVLKPALLGKSLAGYEAILHDIQHLLTGNMSAKAAVEMALYDGWAQMCGLPLYQMLGGYRDTLETDYTVSVNSPEEMAADAENYLKQGFQTLKIKVGKDDIATDIARIQEIRKRVGSAVKLRLDANQGWRPKEAVTAIRKMEDAGLGIELVEQPVHKDDLAGLKKVTDATDTPIMADESVFTPRQAFEVLQTRSADLINIKLMKAGGISGAEKINAMAEACGVECMVGSMIETKLGITAAAHFAASKRNITRFDFDAPLMLKTDVFNGGITYSGSTISMPGKPGLGIIGAALLKGEKEQ
Atome Classification :
(24 SA)
.........10........20........30........40........50..-.-.....60........70........80........90........100.......110.......120.....-.-.130.......140.......150.......160.......170.......180.......190.......200.......210--.--......220.......230.......240.......250.......260.......270.......280.......290.......300.......310.......320.......330......-.340......-..350.......360....
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
M
K
I
I
R
I
ET
S
R
I
A
VPLT
K
P
F
K
T
A
L
R
T
V
YTA
E
S
V
I
V
R
I
T
YDSGAVGWGEAP
P
T
L
V
-
I
-TGD
S
M
D
S
I
E
S
A
I
H
H
V
L
K
P
A
L
LGKSL
A
G
Y
E
A
I
L
H
D
I
Q
H
L
LTGNMS
A
K
A
A
V
E
M
A
L
Y
D
G
W
A
Q
M
C
G
L
P
L
Y
Q
M
LGGYR-D-TLET
D
Y
T
V
SVN
S
P
E
E
M
A
A
D
A
E
N
Y
L
K
QGF
Q
T
L
K
I
K
VG
K
D
D
I
A
T
D
I
A
R
I
Q
E
I
R
K
RVG
S
A
V
K
L
R
L
DANQGW
R
P
K
E
A
V
T
A
I
R
K
M
E
DAG--L--
G
I
E
L
V
EQPV
H
K
D
D
L
A
G
L
K
K
VTDATDTPIMADESVF
T
P
R
Q
A
F
E
V
L
Q
TRSA
D
L
I
N
I
K
L
M
KAGGIS
G
A
E
K
I
N
A
M
A
E
A
CG
V
E
C
M
V
G
S
M
I
E
T
KLG
I
T
A
A
A
H
F
AASKRN
I
T
R
FDFDA
P
L
M
L
K
T
DVFNG
G
I
T
-YSG-
S
T
ISMP-GKP
G
L
G
I
I
G
A
A
LLKGEKEQ
29
PsiBlast_CBE
89.17
100%
-83
- C1 -
1JPM
2
AEEP_BACSU
C:
[1-358]
M
K
I
I
R
I
E
T
S
R
I
A
V
P
L
T
K
P
F
K
T
A
L
R
T
V
Y
T
A
E
S
V
I
V
R
I
T
Y
D
S
G
A
V
G
W
G
E
A
P
P
T
L
V
-
I
-
T
G
D
S
M
D
S
I
E
S
A
I
H
H
V
L
K
P
A
L
L
G
K
S
L
A
G
Y
E
A
I
L
H
D
I
Q
H
L
L
T
G
N
M
S
A
K
A
A
V
E
M
A
L
Y
D
G
W
A
Q
M
C
G
L
P
L
Y
Q
M
L
G
G
Y
R
-
D
-
T
L
E
T
D
Y
T
V
S
V
N
S
P
E
E
M
A
A
D
A
E
N
Y
L
K
Q
G
F
Q
T
L
K
I
K
V
G
K
D
D
I
A
T
D
I
A
R
I
Q
E
I
R
K
R
V
G
S
A
V
K
L
R
L
D
A
N
Q
G
W
R
P
K
E
A
V
T
A
I
R
K
M
E
D
A
G
--
L
--
G
I
E
L
V
E
Q
P
V
H
K
D
D
L
A
G
L
K
K
V
T
D
A
T
D
T
P
I
M
A
D
E
S
V
F
T
P
R
Q
A
F
E
V
L
Q
T
R
S
A
D
L
I
N
I
K
L
M
K
A
G
G
I
S
G
A
E
K
I
N
A
M
A
E
A
C
G
V
E
C
M
V
G
S
M
I
E
T
K
L
G
I
T
A
A
A
H
F
A
A
S
K
R
N
I
T
R
F
D
F
D
A
P
L
M
L
K
T
D
V
F
N
G
G
I
T
-
Y
S
G
-
S
T
I
S
M
P
-
G
K
P
G
L
G
I
I
G
A
A
--------
1
PsiBlast_PDB
88.62
100%
-81
- C1 -
1JPM
2
AEEP_BACSU
A:
[1-359]
M
K
I
I
R
I
E
T
S
R
I
A
V
P
L
T
K
P
F
K
T
A
L
R
T
V
Y
T
A
E
S
V
I
V
R
I
T
Y
D
S
G
A
V
G
W
G
E
A
P
P
T
L
V
-
I
-
T
G
D
S
M
D
S
I
E
S
A
I
H
H
V
L
K
P
A
L
L
G
K
S
L
A
G
Y
E
A
I
L
H
D
I
Q
H
L
L
T
G
N
M
S
A
K
A
A
V
E
M
A
L
Y
D
G
W
A
Q
M
C
G
L
P
L
Y
Q
M
L
G
G
Y
R
-
D
-
T
L
E
T
D
Y
T
V
S
V
N
S
P
E
E
M
A
A
D
A
E
N
Y
L
K
Q
G
F
Q
T
L
K
I
K
V
G
K
D
D
I
A
T
D
I
A
R
I
Q
E
I
R
K
R
V
G
S
A
V
K
L
R
L
D
A
N
Q
G
W
R
P
K
E
A
V
T
A
I
R
K
M
E
D
A
G
--
L
--
G
I
E
L
V
E
Q
P
V
H
K
D
D
L
A
G
L
K
K
V
T
D
A
T
D
T
P
I
M
A
D
E
S
V
F
T
P
R
Q
A
F
E
V
L
Q
T
R
S
A
D
L
I
N
I
K
L
M
K
A
G
G
I
S
G
A
E
K
I
N
A
M
A
E
A
C
G
V
E
C
M
V
G
S
M
I
E
T
K
L
G
I
T
A
A
A
H
F
A
A
S
K
R
N
I
T
R
F
D
F
D
A
P
L
M
L
K
T
D
V
F
N
G
G
I
T
-
Y
S
G
-
S
T
I
S
M
P
-
G
K
P
G
L
G
I
I
G
A
A
L
-------
28
PsiBlast_CBE
88.39
100%
-81
- C1 -
1JPM
1
AEEP_BACSU
D:
[1-358]
M
K
I
I
R
I
E
T
S
R
I
A
V
P
L
T
K
P
F
K
T
A
L
R
T
V
Y
T
A
E
S
V
I
V
R
I
T
Y
D
S
G
A
V
G
W
G
E
A
P
P
T
L
V
-
I
-
T
G
D
S
M
D
S
I
E
S
A
I
H
H
V
L
K
P
A
L
L
G
K
S
L
A
G
Y
E
A
I
L
H
D
I
Q
H
L
L
T
G
N
M
S
A
K
A
A
V
E
M
A
L
Y
D
G
W
A
Q
M
C
G
L
P
L
Y
Q
M
L
G
G
Y
R
-
D
-
T
L
E
T
D
Y
T
V
S
V
N
S
P
E
E
M
A
A
D
A
E
N
Y
L
K
Q
G
F
Q
T
L
K
I
K
V
G
K
D
D
I
A
T
D
I
A
R
I
Q
E
I
R
K
R
V
G
S
A
V
K
L
R
L
D
A
N
Q
G
W
R
P
K
E
A
V
T
A
I
R
K
M
E
D
A
G
--
L
--
G
I
E
L
V
E
Q
P
V
H
K
D
D
L
A
G
L
K
K
V
T
D
A
T
D
T
P
I
M
A
D
E
S
V
F
T
P
R
Q
A
F
E
V
L
Q
T
R
S
A
D
L
I
N
I
K
L
M
K
A
G
G
I
S
G
A
E
K
I
N
A
M
A
E
A
C
G
V
E
C
M
V
G
S
M
I
E
T
K
L
G
I
T
A
A
A
H
F
A
A
S
K
R
N
I
T
R
F
D
F
D
A
P
L
M
L
K
T
D
V
F
N
G
G
I
T
-
Y
S
G
-
S
T
I
S
M
P
-
G
K
P
G
L
G
I
I
G
A
A
--------
30
PsiBlast_CBE
87.29
100%
-80
- C1 -
1JPM
1
AEEP_BACSU
B:
[1-359]
M
K
I
I
R
I
E
T
S
R
I
A
V
P
L
T
K
P
F
K
T
A
L
R
T
V
Y
T
A
E
S
V
I
V
R
I
T
Y
D
S
G
A
V
G
W
G
E
A
P
P
T
L
V
-
I
-
T
G
D
S
M
D
S
I
E
S
A
I
H
H
V
L
K
P
A
L
L
G
K
S
L
A
G
Y
E
A
I
L
H
D
I
Q
H
L
L
T
G
N
M
S
A
K
A
A
V
E
M
A
L
Y
D
G
W
A
Q
M
C
G
L
P
L
Y
Q
M
L
G
G
Y
R
-
D
-
T
L
E
T
D
Y
T
V
S
V
N
S
P
E
E
M
A
A
D
A
E
N
Y
L
K
Q
G
F
Q
T
L
K
I
K
V
G
K
D
D
I
A
T
D
I
A
R
I
Q
E
I
R
K
R
V
G
S
A
V
K
L
R
L
D
A
N
Q
G
W
R
P
K
E
A
V
T
A
I
R
K
M
E
D
A
G
--
L
--
G
I
E
L
V
E
Q
P
V
H
K
D
D
L
A
G
L
K
K
V
T
D
A
T
D
T
P
I
M
A
D
E
S
V
F
T
P
R
Q
A
F
E
V
L
Q
T
R
S
A
D
L
I
N
I
K
L
M
K
A
G
G
I
S
G
A
E
K
I
N
A
M
A
E
A
C
G
V
E
C
M
V
G
S
M
I
E
T
K
L
G
I
T
A
A
A
H
F
A
A
S
K
R
N
I
T
R
F
D
F
D
A
P
L
M
L
K
T
D
V
F
N
G
G
I
T
-
Y
S
G
-
S
T
I
S
M
P
-
G
K
P
G
L
G
I
I
G
A
A
L
-------
21
PsiBlast_CBE
84.45
100%
-76
- C1 -
1TKK
2
AEEP_BACSU
H:
[1-359]
M
K
I
I
R
I
E
T
S
R
I
A
V
P
L
T
K
P
F
K
T
A
L
R
T
V
Y
T
A
E
S
V
I
V
R
I
T
Y
D
S
G
A
V
G
W
G
E
A
P
P
T
L
V
-
I
-
T
G
D
S
M
D
S
I
E
S
A
I
H
H
V
L
K
P
A
L
L
G
K
S
L
A
G
Y
E
A
I
L
H
D
I
Q
H
L
L
T
G
N
M
S
A
K
A
A
V
E
M
A
L
Y
D
G
W
A
Q
M
C
G
L
P
L
Y
Q
M
L
G
G
Y
R
-
D
-
T
L
E
T
D
Y
T
V
S
V
N
S
P
E
E
M
A
A
D
A
E
N
Y
L
K
Q
G
F
Q
T
L
K
I
K
V
G
K
D
D
I
A
T
D
I
A
R
I
Q
E
I
R
K
R
V
G
S
A
V
K
L
R
L
D
A
N
Q
G
W
R
P
K
E
A
V
T
A
I
R
K
M
E
D
A
G
--
L
--
G
I
E
L
V
E
Q
P
V
H
K
D
D
L
A
G
L
K
K
V
T
D
A
T
D
T
P
I
M
A
D
E
S
V
F
T
P
R
Q
A
F
E
V
L
Q
T
R
S
A
D
L
I
N
I
K
L
M
K
A
G
G
I
S
G
A
E
K
I
N
A
M
A
E
A
C
G
V
E
C
M
V
G
S
M
I
E
T
K
L
G
I
T
A
A
A
H
F
A
A
S
K
R
N
I
T
R
F
D
F
D
A
P
L
M
L
K
T
D
V
F
N
G
G
I
T
-
Y
S
G
-
S
T
I
S
M
P
-
G
K
P
G
L
G
I
I
G
A
A
L
-------
2
PsiBlast_PDB
83.99
100%
-75
- C1 -
1TKK
2
AEEP_BACSU
A:
[1-359]
M
K
I
I
R
I
E
T
S
R
I
A
V
P
L
T
K
P
F
K
T
A
L
R
T
V
Y
T
A
E
S
V
I
V
R
I
T
Y
D
S
G
A
V
G
W
G
E
A
P
P
T
L
V
-
I
-
T
G
D
S
M
D
S
I
E
S
A
I
H
H
V
L
K
P
A
L
L
G
K
S
L
A
G
Y
E
A
I
L
H
D
I
Q
H
L
L
T
G
N
M
S
A
K
A
A
V
E
M
A
L
Y
D
G
W
A
Q
M
C
G
L
P
L
Y
Q
M
L
G
G
Y
R
-
D
-
T
L
E
T
D
Y
T
V
S
V
N
S
P
E
E
M
A
A
D
A
E
N
Y
L
K
Q
G
F
Q
T
L
K
I
K
V
G
K
D
D
I
A
T
D
I
A
R
I
Q
E
I
R
K
R
V
G
S
A
V
K
L
R
L
D
A
N
Q
G
W
R
P
K
E
A
V
T
A
I
R
K
M
E
D
A
G
--
L
--
G
I
E
L
V
E
Q
P
V
H
K
D
D
L
A
G
L
K
K
V
T
D
A
T
D
T
P
I
M
A
D
E
S
V
F
T
P
R
Q
A
F
E
V
L
Q
T
R
S
A
D
L
I
N
I
K
L
M
K
A
G
G
I
S
G
A
E
K
I
N
A
M
A
E
A
C
G
V
E
C
M
V
G
S
M
I
E
T
K
L
G
I
T
A
A
A
H
F
A
A
S
K
R
N
I
T
R
F
D
F
D
A
P
L
M
L
K
T
D
V
F
N
G
G
I
T
-
Y
S
G
-
S
T
I
S
M
P
-
G
K
P
G
L
G
I
I
G
A
A
L
-------
27
PsiBlast_CBE
83.98
100%
-77
- C1 -
1TKK
2
AEEP_BACSU
B:
[1-358]
M
K
I
I
R
I
E
T
S
R
I
A
V
P
L
T
K
P
F
K
T
A
L
R
T
V
Y
T
A
E
S
V
I
V
R
I
T
Y
D
S
G
A
V
G
W
G
E
A
P
P
T
L
V
-
I
-
T
G
D
S
M
D
S
I
E
S
A
I
H
H
V
L
K
P
A
L
L
G
K
S
L
A
G
Y
E
A
I
L
H
D
I
Q
H
L
L
T
G
N
M
S
A
K
A
A
V
E
M
A
L
Y
D
G
W
A
Q
M
C
G
L
P
L
Y
Q
M
L
G
G
Y
R
-
D
-
T
L
E
T
D
Y
T
V
S
V
N
S
P
E
E
M
A
A
D
A
E
N
Y
L
K
Q
G
F
Q
T
L
K
I
K
V
G
K
D
D
I
A
T
D
I
A
R
I
Q
E
I
R
K
R
V
G
S
A
V
K
L
R
L
D
A
N
Q
G
W
R
P
K
E
A
V
T
A
I
R
K
M
E
D
A
G
--
L
--
G
I
E
L
V
E
Q
P
V
H
K
D
D
L
A
G
L
K
K
V
T
D
A
T
D
T
P
I
M
A
D
E
S
V
F
T
P
R
Q
A
F
E
V
L
Q
T
R
S
A
D
L
I
N
I
K
L
M
K
A
G
G
I
S
G
A
E
K
I
N
A
M
A
E
A
C
G
V
E
C
M
V
G
S
M
I
E
T
K
L
G
I
T
A
A
A
H
F
A
A
S
K
R
N
I
T
R
F
D
F
D
A
P
L
M
L
K
T
D
V
F
N
G
G
I
T
-
Y
S
G
-
S
T
I
S
M
P
-
G
K
P
G
L
G
I
I
G
A
A
--------
25
PsiBlast_CBE
83.92
100%
-76
- C1 -
1TKK
2
AEEP_BACSU
D:
[1-359]
M
K
I
I
R
I
E
T
S
R
I
A
V
P
L
T
K
P
F
K
T
A
L
R
T
V
Y
T
A
E
S
V
I
V
R
I
T
Y
D
S
G
A
V
G
W
G
E
A
P
P
T
L
V
-
I
-
T
G
D
S
M
D
S
I
E
S
A
I
H
H
V
L
K
P
A
L
L
G
K
S
L
A
G
Y
E
A
I
L
H
D
I
Q
H
L
L
T
G
N
M
S
A
K
A
A
V
E
M
A
L
Y
D
G
W
A
Q
M
C
G
L
P
L
Y
Q
M
L
G
G
Y
R
-
D
-
T
L
E
T
D
Y
T
V
S
V
N
S
P
E
E
M
A
A
D
A
E
N
Y
L
K
Q
G
F
Q
T
L
K
I
K
V
G
K
D
D
I
A
T
D
I
A
R
I
Q
E
I
R
K
R
V
G
S
A
V
K
L
R
L
D
A
N
Q
G
W
R
P
K
E
A
V
T
A
I
R
K
M
E
D
A
G
--
L
--
G
I
E
L
V
E
Q
P
V
H
K
D
D
L
A
G
L
K
K
V
T
D
A
T
D
T
P
I
M
A
D
E
S
V
F
T
P
R
Q
A
F
E
V
L
Q
T
R
S
A
D
L
I
N
I
K
L
M
K
A
G
G
I
S
G
A
E
K
I
N
A
M
A
E
A
C
G
V
E
C
M
V
G
S
M
I
E
T
K
L
G
I
T
A
A
A
H
F
A
A
S
K
R
N
I
T
R
F
D
F
D
A
P
L
M
L
K
T
D
V
F
N
G
G
I
T
-
Y
S
G
-
S
T
I
S
M
P
-
G
K
P
G
L
G
I
I
G
A
A
L
-------
26
PsiBlast_CBE
83.85
100%
-75
- C1 -
1TKK
2
AEEP_BACSU
C:
[1-359]
M
K
I
I
R
I
E
T
S
R
I
A
V
P
L
T
K
P
F
K
T
A
L
R
T
V
Y
T
A
E
S
V
I
V
R
I
T
Y
D
S
G
A
V
G
W
G
E
A
P
P
T
L
V
-
I
-
T
G
D
S
M
D
S
I
E
S
A
I
H
H
V
L
K
P
A
L
L
G
K
S
L
A
G
Y
E
A
I
L
H
D
I
Q
H
L
L
T
G
N
M
S
A
K
A
A
V
E
M
A
L
Y
D
G
W
A
Q
M
C
G
L
P
L
Y
Q
M
L
G
G
Y
R
-
D
-
T
L
E
T
D
Y
T
V
S
V
N
S
P
E
E
M
A
A
D
A
E
N
Y
L
K
Q
G
F
Q
T
L
K
I
K
V
G
K
D
D
I
A
T
D
I
A
R
I
Q
E
I
R
K
R
V
G
S
A
V
K
L
R
L
D
A
N
Q
G
W
R
P
K
E
A
V
T
A
I
R
K
M
E
D
A
G
--
L
--
G
I
E
L
V
E
Q
P
V
H
K
D
D
L
A
G
L
K
K
V
T
D
A
T
D
T
P
I
M
A
D
E
S
V
F
T
P
R
Q
A
F
E
V
L
Q
T
R
S
A
D
L
I
N
I
K
L
M
K
A
G
G
I
S
G
A
E
K
I
N
A
M
A
E
A
C
G
V
E
C
M
V
G
S
M
I
E
T
K
L
G
I
T
A
A
A
H
F
A
A
S
K
R
N
I
T
R
F
D
F
D
A
P
L
M
L
K
T
D
V
F
N
G
G
I
T
-
Y
S
G
-
S
T
I
S
M
P
-
G
K
P
G
L
G
I
I
G
A
A
L
-------
22
PsiBlast_CBE
83.69
100%
-75
- C1 -
1TKK
2
AEEP_BACSU
G:
[1-359]
M
K
I
I
R
I
E
T
S
R
I
A
V
P
L
T
K
P
F
K
T
A
L
R
T
V
Y
T
A
E
S
V
I
V
R
I
T
Y
D
S
G
A
V
G
W
G
E
A
P
P
T
L
V
-
I
-
T
G
D
S
M
D
S
I
E
S
A
I
H
H
V
L
K
P
A
L
L
G
K
S
L
A
G
Y
E
A
I
L
H
D
I
Q
H
L
L
T
G
N
M
S
A
K
A
A
V
E
M
A
L
Y
D
G
W
A
Q
M
C
G
L
P
L
Y
Q
M
L
G
G
Y
R
-
D
-
T
L
E
T
D
Y
T
V
S
V
N
S
P
E
E
M
A
A
D
A
E
N
Y
L
K
Q
G
F
Q
T
L
K
I
K
V
G
K
D
D
I
A
T
D
I
A
R
I
Q
E
I
R
K
R
V
G
S
A
V
K
L
R
L
D
A
N
Q
G
W
R
P
K
E
A
V
T
A
I
R
K
M
E
D
A
G
--
L
--
G
I
E
L
V
E
Q
P
V
H
K
D
D
L
A
G
L
K
K
V
T
D
A
T
D
T
P
I
M
A
D
E
S
V
F
T
P
R
Q
A
F
E
V
L
Q
T
R
S
A
D
L
I
N
I
K
L
M
K
A
G
G
I
S
G
A
E
K
I
N
A
M
A
E
A
C
G
V
E
C
M
V
G
S
M
I
E
T
K
L
G
I
T
A
A
A
H
F
A
A
S
K
R
N
I
T
R
F
D
F
D
A
P
L
M
L
K
T
D
V
F
N
G
G
I
T
-
Y
S
G
-
S
T
I
S
M
P
-
G
K
P
G
L
G
I
I
G
A
A
L
-------
23
PsiBlast_CBE
83.42
100%
-73
- C1 -
1TKK
2
AEEP_BACSU
F:
[1-358]
M
K
I
I
R
I
E
T
S
R
I
A
V
P
L
T
K
P
F
K
T
A
L
R
T
V
Y
T
A
E
S
V
I
V
R
I
T
Y
D
S
G
A
V
G
W
G
E
A
P
P
T
L
V
-
I
-
T
G
D
S
M
D
S
I
E
S
A
I
H
H
V
L
K
P
A
L
L
G
K
S
L
A
G
Y
E
A
I
L
H
D
I
Q
H
L
L
T
G
N
M
S
A
K
A
A
V
E
M
A
L
Y
D
G
W
A
Q
M
C
G
L
P
L
Y
Q
M
L
G
G
Y
R
-
D
-
T
L
E
T
D
Y
T
V
S
V
N
S
P
E
E
M
A
A
D
A
E
N
Y
L
K
Q
G
F
Q
T
L
K
I
K
V
G
K
D
D
I
A
T
D
I
A
R
I
Q
E
I
R
K
R
V
G
S
A
V
K
L
R
L
D
A
N
Q
G
W
R
P
K
E
A
V
T
A
I
R
K
M
E
D
A
G
--
L
--
G
I
E
L
V
E
Q
P
V
H
K
D
D
L
A
G
L
K
K
V
T
D
A
T
D
T
P
I
M
A
D
E
S
V
F
T
P
R
Q
A
F
E
V
L
Q
T
R
S
A
D
L
I
N
I
K
L
M
K
A
G
G
I
S
G
A
E
K
I
N
A
M
A
E
A
C
G
V
E
C
M
V
G
S
M
I
E
T
K
L
G
I
T
A
A
A
H
F
A
A
S
K
R
N
I
T
R
F
D
F
D
A
P
L
M
L
K
T
D
V
F
N
G
G
I
T
-
Y
S
G
-
S
T
I
S
M
P
-
G
K
P
G
L
G
I
I
G
A
A
--------
24
PsiBlast_CBE
83.23
100%
-77
- C1 -
1TKK
2
AEEP_BACSU
E:
[1-359]
M
K
I
I
R
I
E
T
S
R
I
A
V
P
L
T
K
P
F
K
T
A
L
R
T
V
Y
T
A
E
S
V
I
V
R
I
T
Y
D
S
G
A
V
G
W
G
E
A
P
P
T
L
V
-
I
-
T
G
D
S
M
D
S
I
E
S
A
I
H
H
V
L
K
P
A
L
L
G
K
S
L
A
G
Y
E
A
I
L
H
D
I
Q
H
L
L
T
G
N
M
S
A
K
A
A
V
E
M
A
L
Y
D
G
W
A
Q
M
C
G
L
P
L
Y
Q
M
L
G
G
Y
R
-
D
-
T
L
E
T
D
Y
T
V
S
V
N
S
P
E
E
M
A
A
D
A
E
N
Y
L
K
Q
G
F
Q
T
L
K
I
K
V
G
K
D
D
I
A
T
D
I
A
R
I
Q
E
I
R
K
R
V
G
S
A
V
K
L
R
L
D
A
N
Q
G
W
R
P
K
E
A
V
T
A
I
R
K
M
E
D
A
G
--
L
--
G
I
E
L
V
E
Q
P
V
H
K
D
D
L
A
G
L
K
K
V
T
D
A
T
D
T
P
I
M
A
D
E
S
V
F
T
P
R
Q
A
F
E
V
L
Q
T
R
S
A
D
L
I
N
I
K
L
M
K
A
G
G
I
S
G
A
E
K
I
N
A
M
A
E
A
C
G
V
E
C
M
V
G
S
M
I
E
T
K
L
G
I
T
A
A
A
H
F
A
A
S
K
R
N
I
T
R
F
D
F
D
A
P
L
M
L
K
T
D
V
F
N
G
G
I
T
-
Y
S
G
-
S
T
I
S
M
P
-
G
K
P
G
L
G
I
I
G
A
A
L
-------
116
HHSearch
74.94
99%
-75
- C1 -
1TKK
2
AEEP_BACSU
A:
[1-359]
M
K
I
I
R
I
E
T
S
R
I
A
V
P
L
T
K
P
F
K
T
A
L
R
T
V
Y
T
A
E
S
V
I
V
R
I
T
Y
D
S
G
A
V
G
W
G
E
A
P
P
T
-
L
V
I
-
T
G
D
S
M
D
S
I
E
S
A
I
H
H
V
L
K
P
A
L
L
G
K
S
L
A
G
Y
E
A
I
L
H
D
I
Q
H
L
L
T
G
N
M
S
A
K
A
A
V
E
M
A
L
Y
D
G
W
A
Q
M
C
G
L
P
L
Y
Q
M
L
G
G
Y
R
-
D
-
T
L
E
T
D
Y
T
V
S
V
N
S
P
E
E
M
A
A
D
A
E
N
Y
L
K
Q
G
F
Q
T
L
K
I
K
V
G
K
D
D
I
A
T
D
I
A
R
I
Q
E
I
R
K
R
V
G
S
A
V
K
L
R
L
D
A
N
Q
G
W
R
P
K
E
A
V
T
A
I
R
K
M
-
E
-
D
A
G
L
--
G
I
E
L
V
E
Q
P
V
H
K
D
D
L
A
G
L
K
K
V
T
D
A
T
D
T
P
I
M
A
D
E
S
V
F
T
P
R
Q
A
F
E
V
L
Q
T
R
S
A
D
L
I
N
I
K
L
M
K
A
G
G
I
S
G
A
E
K
I
N
A
M
A
E
A
C
G
V
E
C
M
V
G
S
M
I
E
T
K
L
G
I
T
A
A
A
H
F
A
A
S
K
R
N
I
T
R
F
D
F
D
A
P
L
M
L
K
T
D
V
F
N
G
G
I
T
-
Y
S
G
-
S
T
I
S
M
P
-
G
K
P
G
L
G
I
I
G
A
A
L
-------
129
HHSearch
59.93
38%
-95
- C1 -
3Q45
3
AAEP_CYTH3
A:
[1-360]
M
I
I
T
Q
V
E
L
Y
K
S
P
V
K
L
K
E
P
F
K
I
S
L
G
I
L
T
H
A
N
N
V
I
V
R
I
H
T
A
S
G
H
I
G
Y
G
E
C
S
P
F
M
T
-
I
-
H
G
E
S
M
D
T
A
-
F
I
V
G
Q
Y
L
A
K
G
L
I
G
T
S
C
L
D
I
V
S
N
S
L
L
M
D
A
I
I
Y
G
N
S
C
I
K
S
A
F
N
I
A
L
Y
D
L
A
A
Q
H
A
G
L
P
L
Y
A
F
L
G
G
K
K
D
K
-
I
I
Q
T
D
Y
T
V
S
I
D
E
P
H
K
M
A
A
D
A
V
Q
I
K
K
N
G
F
E
I
I
K
V
K
V
G
G
S
-
K
E
L
D
V
E
R
I
R
M
I
R
E
A
A
G
D
S
I
T
L
R
I
D
A
N
Q
G
W
S
V
E
T
A
I
E
T
L
T
L
L
-
E
-
P
--
Y
--
N
I
Q
H
C
E
E
P
V
S
R
N
L
Y
T
A
L
P
K
I
R
Q
A
C
R
I
P
I
M
A
D
E
S
C
C
N
S
F
D
A
E
R
L
I
Q
I
Q
A
C
D
S
F
N
L
K
L
S
K
S
A
G
I
T
N
A
L
N
I
I
R
L
A
E
Q
A
H
M
P
V
Q
V
G
G
F
L
E
S
R
L
G
F
T
A
A
A
H
V
A
L
V
S
K
T
I
C
Y
Y
D
F
D
T
P
L
M
F
E
A
D
P
V
R
G
G
I
V
Y
Q
Q
R
-
G
I
I
E
V
P
-
E
T
A
G
L
G
A
G
Y
Q
K
D
Y
L
S
----
9
PsiBlast_PDB
59.37
39%
-92
- C1 -
3Q4D
3
AAEP_CYTH3
A:
[1-351]
M
I
I
T
Q
V
E
L
Y
K
S
P
V
K
L
K
E
P
F
K
I
S
L
G
I
L
T
H
A
N
N
V
I
V
R
I
H
T
A
S
G
H
I
G
Y
G
E
C
S
P
F
M
T
-
I
-
H
G
E
S
M
D
T
-
A
F
I
V
G
Q
Y
L
A
K
G
L
I
G
T
S
C
L
D
I
V
S
N
S
L
L
M
D
A
I
I
Y
G
N
S
C
I
K
S
A
F
N
I
A
L
Y
D
L
A
A
Q
H
A
G
L
P
L
Y
A
F
L
G
G
K
K
-
D
K
I
I
Q
T
D
Y
T
V
S
I
D
E
P
H
K
M
A
A
D
A
V
Q
I
K
K
N
G
F
E
I
I
K
V
K
V
G
G
S
K
-
E
L
D
V
E
R
I
R
M
I
R
E
A
A
G
D
S
I
T
L
R
I
D
A
N
Q
G
W
S
V
E
T
A
I
E
T
L
T
L
L
E
P
----
Y
--
N
I
Q
H
C
E
E
P
V
S
R
N
L
Y
T
A
L
P
K
I
R
Q
A
C
R
I
P
I
M
A
D
E
S
C
C
N
S
F
D
A
E
R
L
I
Q
I
Q
A
C
D
S
F
N
L
K
L
S
K
S
A
G
I
T
N
A
L
N
I
I
R
L
A
E
Q
A
H
M
P
V
Q
V
G
G
F
L
E
S
R
L
G
F
T
A
A
A
H
V
A
L
V
S
K
T
I
C
Y
Y
D
F
D
T
P
L
M
F
E
A
D
P
V
R
G
G
I
V
-
Y
Q
Q
R
G
I
I
E
V
P
-
E
T
A
G
L
G
-------------
72
PsiBlast_CBE
58.68
39%
-92
- C1 -
3Q4D
3
AAEP_CYTH3
C:
[1-351]
M
I
I
T
Q
V
E
L
Y
K
S
P
V
K
L
K
E
P
F
K
I
S
L
G
I
L
T
H
A
N
N
V
I
V
R
I
H
T
A
S
G
H
I
G
Y
G
E
C
S
P
F
M
T
-
I
-
H
G
E
S
M
D
T
-
A
F
I
V
G
Q
Y
L
A
K
G
L
I
G
T
S
C
L
D
I
V
S
N
S
L
L
M
D
A
I
I
Y
G
N
S
C
I
K
S
A
F
N
I
A
L
Y
D
L
A
A
Q
H
A
G
L
P
L
Y
A
F
L
G
G
K
K
-
D
K
I
I
Q
T
D
Y
T
V
S
I
D
E
P
H
K
M
A
A
D
A
V
Q
I
K
K
N
G
F
E
I
I
K
V
K
V
G
G
S
K
-
E
L
D
V
E
R
I
R
M
I
R
E
A
A
G
D
S
I
T
L
R
I
D
A
N
Q
G
W
S
V
E
T
A
I
E
T
L
T
L
L
E
P
----
Y
--
N
I
Q
H
C
E
E
P
V
S
R
N
L
Y
T
A
L
P
K
I
R
Q
A
C
R
I
P
I
M
A
D
E
S
C
C
N
S
F
D
A
E
R
L
I
Q
I
Q
A
C
D
S
F
N
L
K
L
S
K
S
A
G
I
T
N
A
L
N
I
I
R
L
A
E
Q
A
H
M
P
V
Q
V
G
G
F
L
E
S
R
L
G
F
T
A
A
A
H
V
A
L
V
S
K
T
I
C
Y
Y
D
F
D
T
P
L
M
F
E
A
D
P
V
R
G
G
I
V
-
Y
Q
Q
R
G
I
I
E
V
P
-
E
T
A
G
L
G
-------------
69
PsiBlast_CBE
58.60
39%
-91
- C1 -
3Q4D
2
AAEP_CYTH3
F:
[1-351]
M
I
I
T
Q
V
E
L
Y
K
S
P
V
K
L
K
E
P
F
K
I
S
L
G
I
L
T
H
A
N
N
V
I
V
R
I
H
T
A
S
G
H
I
G
Y
G
E
C
S
P
F
M
T
-
I
-
H
G
E
S
M
D
T
-
A
F
I
V
G
Q
Y
L
A
K
G
L
I
G
T
S
C
L
D
I
V
S
N
S
L
L
M
D
A
I
I
Y
G
N
S
C
I
K
S
A
F
N
I
A
L
Y
D
L
A
A
Q
H
A
G
L
P
L
Y
A
F
L
G
G
K
K
-
D
K
I
I
Q
T
D
Y
T
V
S
I
D
E
P
H
K
M
A
A
D
A
V
Q
I
K
K
N
G
F
E
I
I
K
V
K
V
G
G
S
K
-
E
L
D
V
E
R
I
R
M
I
R
E
A
A
G
D
S
I
T
L
R
I
D
A
N
Q
G
W
S
V
E
T
A
I
E
T
L
T
L
L
E
P
----
Y
--
N
I
Q
H
C
E
E
P
V
S
R
N
L
Y
T
A
L
P
K
I
R
Q
A
C
R
I
P
I
M
A
D
E
S
C
C
N
S
F
D
A
E
R
L
I
Q
I
Q
A
C
D
S
F
N
L
K
L
S
K
S
A
G
I
T
N
A
L
N
I
I
R
L
A
E
Q
A
H
M
P
V
Q
V
G
G
F
L
E
S
R
L
G
F
T
A
A
A
H
V
A
L
V
S
K
T
I
C
Y
Y
D
F
D
T
P
L
M
F
E
A
D
P
V
R
G
G
I
V
-
Y
Q
Q
R
G
I
I
E
V
P
-
E
T
A
G
L
G
-------------
66
PsiBlast_CBE
58.59
39%
-92
- C1 -
3Q4D
10
AAEP_CYTH3
I:
[1-351]
M
I
I
T
Q
V
E
L
Y
K
S
P
V
K
L
K
E
P
F
K
I
S
L
G
I
L
T
H
A
N
N
V
I
V
R
I
H
T
A
S
G
H
I
G
Y
G
E
C
S
P
F
M
T
-
I
-
H
G
E
S
M
D
T
-
A
F
I
V
G
Q
Y
L
A
K
G
L
I
G
T
S
C
L
D
I
V
S
N
S
L
L
M
D
A
I
I
Y
G
N
S
C
I
K
S
A
F
N
I
A
L
Y
D
L
A
A
Q
H
A
G
L
P
L
Y
A
F
L
G
G
K
K
-
D
K
I
I
Q
T
D
Y
T
V
S
I
D
E
P
H
K
M
A
A
D
A
V
Q
I
K
K
N
G
F
E
I
I
K
V
K
V
G
G
S
K
-
E
L
D
V
E
R
I
R
M
I
R
E
A
A
G
D
S
I
T
L
R
I
D
A
N
Q
G
W
S
V
E
T
A
I
E
T
L
T
L
L
E
P
----
Y
--
N
I
Q
H
C
E
E
P
V
S
R
N
L
Y
T
A
L
P
K
I
R
Q
A
C
R
I
P
I
M
A
D
E
S
C
C
N
S
F
D
A
E
R
L
I
Q
I
Q
A
C
D
S
F
N
L
K
L
S
K
S
A
G
I
T
N
A
L
N
I
I
R
L
A
E
Q
A
H
M
P
V
Q
V
G
G
F
L
E
S
R
L
G
F
T
A
A
A
H
V
A
L
V
S
K
T
I
C
Y
Y
D
F
D
T
P
L
M
F
E
A
D
P
V
R
G
G
I
V
-
Y
Q
Q
R
G
I
I
E
V
P
-
E
T
A
G
L
G
-------------
81
PsiBlast_CBE
58.46
39%
-94
- C1 -
3Q45
3
AAEP_CYTH3
B:
[1-351]
M
I
I
T
Q
V
E
L
Y
K
S
P
V
K
L
K
E
P
F
K
I
S
L
G
I
L
T
H
A
N
N
V
I
V
R
I
H
T
A
S
G
H
I
G
Y
G
E
C
S
P
F
M
T
-
I
-
H
G
E
S
M
D
T
-
A
F
I
V
G
Q
Y
L
A
K
G
L
I
G
T
S
C
L
D
I
V
S
N
S
L
L
M
D
A
I
I
Y
G
N
S
C
I
K
S
A
F
N
I
A
L
Y
D
L
A
A
Q
H
A
G
L
P
L
Y
A
F
L
G
G
K
K
-
D
K
I
I
Q
T
D
Y
T
V
S
I
D
E
P
H
K
M
A
A
D
A
V
Q
I
K
K
N
G
F
E
I
I
K
V
K
V
G
G
S
K
-
E
L
D
V
E
R
I
R
M
I
R
E
A
A
G
D
S
I
T
L
R
I
D
A
N
Q
G
W
S
V
E
T
A
I
E
T
L
T
L
L
E
P
----
Y
--
N
I
Q
H
C
E
E
P
V
S
R
N
L
Y
T
A
L
P
K
I
R
Q
A
C
R
I
P
I
M
A
D
E
S
C
C
N
S
F
D
A
E
R
L
I
Q
I
Q
A
C
D
S
F
N
L
K
L
S
K
S
A
G
I
T
N
A
L
N
I
I
R
L
A
E
Q
A
H
M
P
V
Q
V
G
G
F
L
E
S
R
L
G
F
T
A
A
A
H
V
A
L
V
S
K
T
I
C
Y
Y
D
F
D
T
P
L
M
F
E
A
D
P
V
R
G
G
I
V
-
Y
Q
Q
R
G
I
I
E
V
P
-
E
T
A
G
L
G
-------------
73
PsiBlast_CBE
58.35
39%
-91
- C1 -
3Q4D
3
AAEP_CYTH3
B:
[1-351]
M
I
I
T
Q
V
E
L
Y
K
S
P
V
K
L
K
E
P
F
K
I
S
L
G
I
L
T
H
A
N
N
V
I
V
R
I
H
T
A
S
G
H
I
G
Y
G
E
C
S
P
F
M
T
-
I
-
H
G
E
S
M
D
T
-
A
F
I
V
G
Q
Y
L
A
K
G
L
I
G
T
S
C
L
D
I
V
S
N
S
L
L
M
D
A
I
I
Y
G
N
S
C
I
K
S
A
F
N
I
A
L
Y
D
L
A
A
Q
H
A
G
L
P
L
Y
A
F
L
G
G
K
K
-
D
K
I
I
Q
T
D
Y
T
V
S
I
D
E
P
H
K
M
A
A
D
A
V
Q
I
K
K
N
G
F
E
I
I
K
V
K
V
G
G
S
K
-
E
L
D
V
E
R
I
R
M
I
R
E
A
A
G
D
S
I
T
L
R
I
D
A
N
Q
G
W
S
V
E
T
A
I
E
T
L
T
L
L
E
P
----
Y
--
N
I
Q
H
C
E
E
P
V
S
R
N
L
Y
T
A
L
P
K
I
R
Q
A
C
R
I
P
I
M
A
D
E
S
C
C
N
S
F
D
A
E
R
L
I
Q
I
Q
A
C
D
S
F
N
L
K
L
S
K
S
A
G
I
T
N
A
L
N
I
I
R
L
A
E
Q
A
H
M
P
V
Q
V
G
G
F
L
E
S
R
L
G
F
T
A
A
A
H
V
A
L
V
S
K
T
I
C
Y
Y
D
F
D
T
P
L
M
F
E
A
D
P
V
R
G
G
I
V
-
Y
Q
Q
R
G
I
I
E
V
P
-
E
T
A
G
L
G
-------------
17
PsiBlast_PDB
50.57
32%
-96
- C1 -
3R1Z
8
XEEP_FRAP2
A:
[4-344]
-
K
I
I
D
I
K
T
S
I
I
K
I
P
L
K
R
T
F
I
T
A
V
R
S
T
N
H
I
D
S
L
A
V
E
L
T
L
D
N
G
V
K
G
Y
G
V
A
P
A
T
T
A
-
I
-
T
G
D
T
L
Q
G
M
Q
Y
I
I
R
E
I
F
A
P
V
I
L
G
S
D
L
S
D
Y
K
Q
T
L
E
L
A
F
K
K
V
M
F
N
S
A
A
K
M
A
I
D
L
A
Y
H
D
L
L
A
K
E
Q
D
I
S
V
A
K
L
L
G
A
K
A
-
N
-
S
I
V
T
D
V
S
I
S
C
G
N
V
A
E
T
I
Q
N
I
Q
N
G
V
E
A
N
F
T
A
I
K
V
K
T
G
A
D
-
F
N
R
D
I
Q
L
L
K
A
L
D
N
E
F
S
K
N
I
K
F
R
F
D
A
N
Q
G
W
N
L
A
Q
T
K
Q
F
I
E
E
I
N
K
Y
S
--
L
--
N
V
E
I
I
E
Q
P
V
K
Y
Y
D
I
K
A
M
A
E
I
T
K
F
S
N
I
P
V
V
A
D
E
S
V
F
D
A
K
D
A
E
R
V
I
D
E
Q
A
C
N
M
I
N
I
K
L
A
K
T
G
G
I
L
E
A
Q
K
I
K
K
L
A
D
S
A
G
I
S
C
M
V
G
C
M
M
E
S
P
A
G
I
L
A
T
A
S
F
A
L
A
E
-
D
I
T
V
A
D
L
D
P
L
D
W
V
A
K
D
L
Y
S
D
Y
I
T
-
F
N
E
-
P
N
I
-----------------------
14
PsiBlast_PDB
50.42
32%
-93
- C1 -
3R0U
9
XEEP_FRAP2
A:
[4-344]
-
K
I
I
D
I
K
T
S
I
I
K
I
P
L
K
R
T
F
I
T
A
V
R
S
T
N
H
I
D
S
L
A
V
E
L
T
L
D
N
G
V
K
G
Y
G
V
A
P
A
T
T
A
-
I
-
T
G
D
T
L
Q
G
M
Q
Y
I
I
R
E
I
F
A
P
V
I
L
G
S
D
L
S
D
Y
K
Q
T
L
E
L
A
F
K
K
V
M
F
N
S
A
A
K
M
A
I
D
L
A
Y
H
D
L
L
A
K
E
Q
D
I
S
V
A
K
L
L
G
A
K
A
-
N
-
S
I
V
T
D
V
S
I
S
C
G
N
V
A
E
T
I
Q
N
I
Q
N
G
V
E
A
N
F
T
A
I
K
V
K
T
G
A
D
-
F
N
R
D
I
Q
L
L
K
A
L
D
N
E
F
S
K
N
I
K
F
R
F
D
A
N
Q
G
W
N
L
A
Q
T
K
Q
F
I
E
E
I
N
K
Y
S
--
L
--
N
V
E
I
I
E
Q
P
V
K
Y
Y
D
I
K
A
M
A
E
I
T
K
F
S
N
I
P
V
V
A
D
E
S
V
F
D
A
K
D
A
E
R
V
I
D
E
Q
A
C
N
M
I
N
I
K
L
A
K
T
G
G
I
L
E
A
Q
K
I
K
K
L
A
D
S
A
G
I
S
C
M
V
G
C
M
M
E
S
P
A
G
I
L
A
T
A
S
F
A
L
A
E
-
D
I
T
V
A
D
L
D
P
L
D
W
V
A
K
D
L
Y
S
D
Y
I
T
-
F
N
E
-
P
N
I
-----------------------
118
HHSearch
49.93
33%
-90
- C1 -
3R0U
9
XEEP_FRAP2
A:
[3-360]
S
K
I
I
D
I
K
T
S
I
I
K
I
P
L
K
R
T
F
I
T
A
V
R
S
T
N
H
I
D
S
L
A
V
E
L
T
L
D
N
G
V
K
G
Y
G
V
A
P
A
T
-
T
-
A
I
T
G
D
T
L
Q
G
M
Q
Y
I
I
R
E
I
F
A
P
V
I
L
G
S
D
L
S
D
Y
K
Q
T
L
E
L
A
F
K
K
V
M
F
N
S
A
A
K
M
A
I
D
L
A
Y
H
D
L
L
A
K
E
Q
D
I
S
V
A
K
L
L
G
A
K
A
-
N
-
S
I
V
T
D
V
S
I
S
C
G
N
V
A
E
T
I
Q
N
I
Q
N
G
V
E
A
N
F
T
A
I
K
V
K
T
G
A
D
-
F
N
R
D
I
Q
L
L
K
A
L
D
N
E
F
S
K
N
I
K
F
R
F
D
A
N
Q
G
W
N
L
A
Q
T
K
Q
F
I
E
E
I
-
N
-
K
--
Y
SL
N
V
E
I
I
E
Q
P
V
K
Y
Y
D
I
K
A
M
A
E
I
T
K
F
S
N
I
P
V
V
A
D
E
S
V
F
D
A
K
D
A
E
R
V
I
D
E
Q
A
C
N
M
I
N
I
K
L
A
K
T
G
G
I
L
E
A
Q
K
I
K
K
L
A
D
S
A
G
I
S
C
M
V
G
C
M
M
E
S
P
A
G
I
L
A
T
A
S
F
A
L
A
E
-
D
I
T
V
A
D
L
D
P
L
D
W
V
A
K
D
L
Y
S
D
Y
I
T
-
F
N
E
-
P
N
I
I
L
K
D
N
L
K
G
F
G
F
N
L
A
E
N
-------
13
PsiBlast_PDB
47.10
32%
-95
- C1 -
3R0K
5
XEEP_FRAP2
A:
[4-344]
-
K
I
I
D
I
K
T
S
I
I
K
I
P
L
K
R
T
F
I
-------
H
I
D
S
L
A
V
E
L
T
L
D
N
G
V
K
G
Y
G
V
A
P
A
T
T
A
-
I
-
T
G
D
T
L
Q
G
M
Q
Y
I
I
R
E
I
F
A
P
V
I
L
G
S
D
L
S
D
Y
K
Q
T
L
E
L
A
F
K
K
V
M
F
N
S
A
A
K
M
A
I
D
L
A
Y
H
D
L
L
A
K
E
Q
D
I
S
V
A
K
L
L
G
A
K
A
-
N
-
S
I
V
T
D
V
S
I
S
C
G
N
V
A
E
T
I
Q
N
I
Q
N
G
V
E
A
N
F
T
A
I
K
V
K
T
G
A
D
-
F
N
R
D
I
Q
L
L
K
A
L
D
N
E
F
S
K
N
I
K
F
R
F
D
A
N
Q
G
W
N
L
A
Q
T
K
Q
F
I
E
E
I
N
K
Y
S
--
L
--
N
V
E
I
I
E
Q
P
V
K
Y
Y
D
I
K
A
M
A
E
I
T
K
F
S
N
I
P
V
V
A
D
E
S
V
F
D
A
K
D
A
E
R
V
I
D
E
Q
A
C
N
M
I
N
I
K
L
A
K
T
G
G
I
L
E
A
Q
K
I
K
K
L
A
D
S
A
G
I
S
C
M
V
G
C
M
M
E
S
P
A
G
I
L
A
T
A
S
F
A
L
A
E
-
D
I
T
V
A
D
L
D
P
L
D
W
V
A
K
D
L
Y
S
D
Y
I
T
-
F
N
E
-
P
N
I
-----------------------