@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : bsu13960: (2016-06-21 )
MKKTIGFIGLGVMGKSMASHILNDGHPVLVYTRTKEKAESILQKGAIWKDTVKDLSKEADVIITMVGYPSDVEEVYFGSNGIIENAKEGAYLIDMTTSKPSLAKKIAEAAKEKALFALDAPVSGGDIGAQNGTLAIMVGGEKEAFEACMPIFSLMGENIQYQGPAGSGQHTKMCNQIAIAAGMIGVAEAMAYAQKSGLEPENVLKSITTGAAGSWSLSNLAPRMLQGNFEPGFYVKHFIKDMGIALEEAELMGEEMPGLSLAKSLYDKLAAQGEENSGTQSIYKLWVK
Atome Classification :
(28 SA)
.........10........20........30........40..-.-.....50........60--------.....--...70........80......----..90........100.......110.......120.......130.......140.......150.......160----....-.....170.......180.......190.......200.......210......--.220.--.-------..-----..-----..230.......240.......250......--.260.......270.......280......
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MK
K
T
I
G
F
I
G
L
G
V
M
G
K
S
M
A
S
H
I
LNDG
H
P
V
L
V
Y
TR
T
K
E
K
A
E
S
I
L
Q
-K-GA
I
W
K
D
T
V
K
D
L
SKEA
D
V
--------
I
I
T
MV--GYPS
D
V
E
E
VYFGSNGIIENAK----E
G
A
Y
L
I
D
MTTS
K
P
S
L
A
K
K
I
A
E
A
A
K
EK
A
L
F
A
LDAPVSGGDIGAQN
G
T
L
A
I
M
VGG
E
K
E
A
F
E
A
C
M
P
I
F
S
L
MGE
N
I
Q
------
Y
QGP-AGS
G
Q
H
T
K
M
C
N
Q
I
A
I
A
A
G
M
I
G
V
A
E
A
M
A
Y
A
Q
KSGL
E
P
E
N
V
L
K
S
I
TTGAAGSW
S
L
S
--NL
A
-
P
--
R
-------
M
L-----QG-----NFEP
G
F
Y
V
K
H
F
I
K
D
MGI
A
L
E
E
A
E
L
M
G
EEMP
G
--
L
S
L
A
K
S
L
Y
D
K
L
A
AQGEENS
G
T
Q
S
I
Y
K
L
WVK
47
HHSearch
85.13
40%
-131
- C1 -
3WS7
3
?
A:
[19-303]
S
H
M
R
V
G
F
I
G
L
G
I
M
G
G
P
M
A
T
H
L
L
K
A
G
F
L
A
A
V
Y
N
R
T
R
E
K
T
K
P
F
A
E
-
A
-
G
V
Y
V
A
E
S
P
A
D
L
A
K
R
V
D
V
--------
V
I
V
M
V
--
S
D
A
P
D
V
E
Q
V
L
F
G
P
S
G
V
V
E
G
A
R
----
P
G
L
I
V
V
D
M
S
T
N
S
P
D
W
A
R
K
F
A
E
R
L
A
Q
Y
G
I
E
F
L
D
A
P
V
T
G
G
Q
K
G
A
I
E
G
T
L
T
I
M
V
G
G
K
E
E
L
F
H
R
L
L
P
I
F
K
A
M
G
R
D
I
V
------
Y
M
G
P
-
V
G
Y
G
Q
A
M
K
L
V
N
Q
V
V
V
A
L
N
T
V
A
M
V
E
G
L
K
L
A
K
A
L
G
L
D
M
D
K
V
A
E
V
L
T
---
A
R
S
G
A
I
E
--
L
Y
L
-
P
--
K
-------
L
L
-----
K
G
-----
D
L
S
P
G
F
K
A
E
H
L
K
K
D
L
G
Y
V
L
E
E
A
R
K
R
G
V
K
L
P
G
--
A
E
L
A
Y
E
L
Y
R
K
M
V
E
D
G
A
G
S
L
G
I
H
A
L
G
F
Y
---
2
PsiBlast_PDB
84.01
41%
-140
- C1 -
3W6Z
1
?
A:
[23-300]
----
V
G
F
I
G
L
G
I
M
G
G
P
M
A
T
H
L
L
K
A
G
F
L
A
A
V
Y
N
R
T
R
E
K
T
K
P
F
A
E
-
A
-
G
V
Y
V
A
E
S
P
A
D
L
A
K
R
V
D
V
--------
V
I
V
M
V
--
S
D
A
P
D
V
E
Q
V
L
F
G
P
S
G
V
V
E
G
A
R
----
P
G
L
I
V
V
D
M
S
T
N
S
P
D
W
A
R
K
F
A
E
R
L
A
Q
Y
G
I
E
F
L
D
A
P
V
T
G
G
Q
K
G
A
I
E
G
T
L
T
I
M
V
G
G
K
E
E
L
F
H
R
L
L
P
I
F
K
A
M
G
R
D
I
V
------
Y
M
G
P
-
V
G
Y
G
Q
A
M
M
L
V
N
Q
V
V
V
A
L
N
T
V
A
M
V
E
G
L
K
L
A
K
A
L
G
L
D
M
D
K
V
A
E
V
L
T
R
G
A
A
R
S
G
A
I
E
--
L
Y
L
-
P
--
K
-------
L
L
-----
K
G
-----
D
L
S
P
G
F
K
A
E
H
L
K
K
D
L
G
Y
V
L
E
E
A
R
K
R
G
V
K
L
P
G
--
A
E
L
A
Y
E
L
Y
R
K
M
V
---
E
D
G
A
G
S
L
G
I
H
A
L
---
1
PsiBlast_PDB
83.36
41%
-138
- C1 -
3WS7
3
?
A:
[23-300]
----
V
G
F
I
G
L
G
I
M
G
G
P
M
A
T
H
L
L
K
A
G
F
L
A
A
V
Y
N
R
T
R
E
K
T
K
P
F
A
E
-
A
-
G
V
Y
V
A
E
S
P
A
D
L
A
K
R
V
D
V
--------
V
I
V
M
V
--
S
D
A
P
D
V
E
Q
V
L
F
G
P
S
G
V
V
E
G
A
R
----
P
G
L
I
V
V
D
M
S
T
N
S
P
D
W
A
R
K
F
A
E
R
L
A
Q
Y
G
I
E
F
L
D
A
P
V
T
G
G
Q
K
G
A
I
E
G
T
L
T
I
M
V
G
G
K
E
E
L
F
H
R
L
L
P
I
F
K
A
M
G
R
D
I
V
------
Y
M
G
P
-
V
G
Y
G
Q
A
M
K
L
V
N
Q
V
V
V
A
L
N
T
V
A
M
V
E
G
L
K
L
A
K
A
L
G
L
D
M
D
K
V
A
E
V
L
T
---
A
R
S
G
A
I
E
--
L
Y
L
-
P
--
K
-------
L
L
-----
K
G
-----
D
L
S
P
G
F
K
A
E
H
L
K
K
D
L
G
Y
V
L
E
E
A
R
K
R
G
V
K
L
P
G
--
A
E
L
A
Y
E
L
Y
R
K
M
V
---
E
D
G
A
G
S
L
G
I
H
A
L
---
41
HHSearch
81.23
37%
-109
- C1 -
1VPD
2
?
A:
[6-290]
--
M
K
V
G
F
I
G
L
G
I
M
G
K
P
M
S
K
N
L
L
K
A
G
Y
S
L
V
V
S
D
R
N
P
E
A
I
A
D
V
I
A
-
A
-
G
A
E
T
A
S
T
A
K
A
I
A
E
Q
C
D
V
--------
I
I
T
M
L
--
P
N
S
P
H
V
K
E
V
A
L
G
E
N
G
I
I
E
G
A
K
----
P
G
T
V
L
I
D
M
S
S
I
A
P
L
A
S
R
E
I
S
D
A
L
K
A
K
G
V
E
M
L
D
A
P
V
S
G
G
E
P
K
A
I
D
G
T
L
S
V
M
V
G
G
D
K
A
I
F
D
K
Y
Y
D
L
M
K
A
M
A
G
S
V
V
------
H
T
G
D
-
I
G
A
G
N
V
T
K
L
A
N
Q
V
I
V
A
L
N
I
A
A
M
S
E
A
L
T
L
A
T
K
A
G
V
N
P
D
L
V
Y
Q
A
I
R
G
G
L
A
G
S
T
V
L
D
--
A
K
A
-
P
--
M
-------
V
M
-----
D
R
-----
N
F
K
P
G
F
R
I
D
L
H
I
K
D
L
A
N
A
L
D
T
S
H
G
V
G
A
Q
L
P
L
--
T
A
A
V
M
E
M
M
Q
A
L
R
A
D
G
H
G
N
D
D
H
S
A
L
A
C
Y
Y
E
-
4
PsiBlast_PDB
79.38
34%
-108
- C1 -
1VPD
2
?
A:
[6-291]
--
M
K
V
G
F
I
G
L
G
I
M
G
K
P
M
S
K
N
L
L
K
A
G
Y
S
L
V
V
S
D
R
N
P
E
A
I
A
D
V
I
A
-
A
-
G
A
E
T
A
S
T
A
K
A
I
A
E
Q
C
D
V
--------
I
I
T
M
L
--
P
N
S
P
H
V
K
E
V
A
L
G
E
N
G
I
I
E
G
A
K
----
P
G
T
V
L
I
D
M
S
S
I
A
P
L
A
S
R
E
I
S
D
A
L
K
A
K
G
V
E
M
L
D
A
P
V
S
G
G
E
P
K
A
I
D
G
T
L
S
V
M
V
G
G
D
K
A
I
F
D
K
Y
Y
D
L
M
K
A
M
A
G
S
V
V
------
H
T
G
D
-
I
G
A
G
N
V
T
K
L
A
N
Q
V
I
V
A
L
N
I
A
A
M
S
E
A
L
T
L
A
T
K
A
G
V
N
P
D
L
V
Y
Q
A
I
R
G
G
L
A
G
S
T
V
L
D
--
A
K
A
-
P
--
M
-------
V
M
-----
D
R
-----
N
F
K
P
G
F
R
I
D
L
H
I
K
D
L
A
N
A
L
D
T
S
H
G
V
G
A
Q
L
P
L
--
T
A
A
V
M
E
M
M
Q
A
L
R
A
D
G
H
G
N
D
D
H
S
A
L
A
C
Y
Y
E
K
40
HHSearch
77.02
37%
-122
- C1 -
3OBB
5
SERDH_PSEAE
A:
[3-295]
-
M
K
Q
I
A
F
I
G
L
G
H
M
G
A
P
M
A
T
N
L
L
K
A
G
Y
L
L
N
V
F
D
L
V
Q
S
A
V
D
G
L
V
A
-
A
-
G
A
S
A
A
R
S
A
R
D
A
V
Q
G
A
D
V
--------
V
I
S
M
L
--
P
A
S
Q
H
V
E
G
L
Y
L
D
D
D
G
L
L
A
H
I
A
----
P
-
T
L
V
L
E
C
S
T
I
A
P
T
S
A
R
K
I
H
A
A
A
R
E
R
G
L
A
M
L
D
A
P
V
S
G
G
T
A
G
A
A
A
G
T
L
T
F
M
V
G
G
D
A
E
A
L
E
K
A
R
P
L
F
E
A
M
G
R
N
I
F
------
H
A
G
P
-
D
G
A
G
Q
V
A
K
V
C
N
N
Q
L
L
A
V
L
M
I
G
T
A
E
A
M
A
L
G
V
A
N
G
L
E
A
K
V
L
A
E
I
M
R
R
S
S
G
G
N
W
A
L
E
--
V
Y
N
-
P
--
W
PGVMENA
P
A
-----
S
R
-----
D
Y
S
G
G
F
M
A
Q
L
M
A
K
D
L
G
L
A
Q
E
A
A
Q
A
S
A
S
S
T
P
M
--
G
S
L
A
L
S
L
Y
R
L
L
L
K
Q
G
Y
A
E
R
D
F
S
V
V
Q
K
L
F
D
-
21
PsiBlast_CBE
76.35
32%
-120
- C1 -
2I9P
1
3HIDH_HUMAN
D:
[25-312]
----
V
G
F
I
G
L
G
N
M
G
N
P
M
A
K
N
L
M
K
H
G
Y
P
L
I
I
Y
D
V
F
P
D
A
C
K
E
F
Q
D
-
A
-
G
E
Q
V
V
S
S
P
A
D
V
A
E
K
A
D
R
--------
I
I
T
M
L
--
P
T
S
I
N
A
I
E
A
Y
S
G
A
N
G
I
L
K
K
V
K
----
K
G
S
L
L
I
D
S
S
T
I
D
P
A
V
S
K
E
L
A
K
E
V
E
K
M
G
A
V
F
M
D
A
P
V
S
G
G
V
G
A
A
R
S
G
N
L
T
F
M
V
G
G
V
E
D
E
F
A
A
A
Q
E
L
L
G
C
M
G
S
N
V
V
------
Y
C
G
A
-
V
G
T
G
Q
A
A
K
I
C
N
N
M
L
L
A
I
S
M
I
G
T
A
E
A
M
N
L
G
I
R
L
G
L
D
P
K
L
L
A
K
I
L
N
M
S
S
G
R
C
W
S
S
D
TY
N
P
V
-
P
--
G
-------
V
M
-----
D
G
VPSAN
N
Y
Q
G
G
F
G
T
T
L
M
A
K
D
L
G
L
A
Q
D
S
A
T
S
T
K
S
P
I
L
L
--
G
S
L
A
H
Q
I
Y
R
M
M
C
A
K
G
Y
S
K
K
D
F
S
S
V
F
Q
F
---
22
PsiBlast_CBE
76.23
32%
-117
- C1 -
2I9P
1
3HIDH_HUMAN
C:
[25-312]
----
V
G
F
I
G
L
G
N
M
G
N
P
M
A
K
N
L
M
K
H
G
Y
P
L
I
I
Y
D
V
F
P
D
A
C
K
E
F
Q
D
-
A
-
G
E
Q
V
V
S
S
P
A
D
V
A
E
K
A
D
R
--------
I
I
T
M
L
--
P
T
S
I
N
A
I
E
A
Y
S
G
A
N
G
I
L
K
K
V
K
----
K
G
S
L
L
I
D
S
S
T
I
D
P
A
V
S
K
E
L
A
K
E
V
E
K
M
G
A
V
F
M
D
A
P
V
S
G
G
V
G
A
A
R
S
G
N
L
T
F
M
V
G
G
V
E
D
E
F
A
A
A
Q
E
L
L
G
C
M
G
S
N
V
V
------
Y
C
G
A
-
V
G
T
G
Q
A
A
K
I
C
N
N
M
L
L
A
I
S
M
I
G
T
A
E
A
M
N
L
G
I
R
L
G
L
D
P
K
L
L
A
K
I
L
N
M
S
S
G
R
C
W
S
S
D
TY
N
P
V
-
P
--
G
-------
V
M
-----
D
G
VPSAN
N
Y
Q
G
G
F
G
T
T
L
M
A
K
D
L
G
L
A
Q
D
S
A
T
S
T
K
S
P
I
L
L
--
G
S
L
A
H
Q
I
Y
R
M
M
C
A
K
G
Y
S
K
K
D
F
S
S
V
F
Q
F
---
7
PsiBlast_PDB
75.83
32%
-119
- C1 -
2I9P
1
3HIDH_HUMAN
A:
[25-312]
----
V
G
F
I
G
L
G
N
M
G
N
P
M
A
K
N
L
M
K
H
G
Y
P
L
I
I
Y
D
V
F
P
D
A
C
K
E
F
Q
D
-
A
-
G
E
Q
V
V
S
S
P
A
D
V
A
E
K
A
D
R
--------
I
I
T
M
L
--
P
T
S
I
N
A
I
E
A
Y
S
G
A
N
G
I
L
K
K
V
K
----
K
G
S
L
L
I
D
S
S
T
I
D
P
A
V
S
K
E
L
A
K
E
V
E
K
M
G
A
V
F
M
D
A
P
V
S
G
G
V
G
A
A
R
S
G
N
L
T
F
M
V
G
G
V
E
D
E
F
A
A
A
Q
E
L
L
G
C
M
G
S
N
V
V
------
Y
C
G
A
-
V
G
T
G
Q
A
A
K
I
C
N
N
M
L
L
A
I
S
M
I
G
T
A
E
A
M
N
L
G
I
R
L
G
L
D
P
K
L
L
A
K
I
L
N
M
S
S
G
R
C
W
S
S
D
TY
N
P
V
-
P
--
G
-------
V
M
-----
D
G
VPSAN
N
Y
Q
G
G
F
G
T
T
L
M
A
K
D
L
G
L
A
Q
D
S
A
T
S
T
K
S
P
I
L
L
--
G
S
L
A
H
Q
I
Y
R
M
M
C
A
K
G
Y
S
K
K
D
F
S
S
V
F
Q
F
---
23
PsiBlast_CBE
75.78
32%
-120
- C1 -
2I9P
1
3HIDH_HUMAN
B:
[25-312]
----
V
G
F
I
G
L
G
N
M
G
N
P
M
A
K
N
L
M
K
H
G
Y
P
L
I
I
Y
D
V
F
P
D
A
C
K
E
F
Q
D
-
A
-
G
E
Q
V
V
S
S
P
A
D
V
A
E
K
A
D
R
--------
I
I
T
M
L
--
P
T
S
I
N
A
I
E
A
Y
S
G
A
N
G
I
L
K
K
V
K
----
K
G
S
L
L
I
D
S
S
T
I
D
P
A
V
S
K
E
L
A
K
E
V
E
K
M
G
A
V
F
M
D
A
P
V
S
G
G
V
G
A
A
R
S
G
N
L
T
F
M
V
G
G
V
E
D
E
F
A
A
A
Q
E
L
L
G
C
M
G
S
N
V
V
------
Y
C
G
A
-
V
G
T
G
Q
A
A
K
I
C
N
N
M
L
L
A
I
S
M
I
G
T
A
E
A
M
N
L
G
I
R
L
G
L
D
P
K
L
L
A
K
I
L
N
M
S
S
G
R
C
W
S
S
D
TY
N
P
V
-
P
--
G
-------
V
M
-----
D
G
VPSAN
N
Y
Q
G
G
F
G
T
T
L
M
A
K
D
L
G
L
A
Q
D
S
A
T
S
T
K
S
P
I
L
L
--
G
S
L
A
H
Q
I
Y
R
M
M
C
A
K
G
Y
S
K
K
D
F
S
S
V
F
Q
F
---
9
PsiBlast_PDB
74.66
30%
-108
- C1 -
3PEF
6
?
A:
[2-285]
--
Q
K
F
G
F
I
G
L
G
I
M
G
S
A
M
A
K
N
L
V
K
A
G
C
S
V
T
I
W
N
R
S
P
E
K
A
E
E
L
A
A
-
L
-
G
A
E
R
A
A
T
P
C
E
V
V
E
S
C
P
V
--------
T
F
A
M
L
--
A
D
P
A
A
A
E
E
V
C
F
G
K
H
G
V
L
E
G
I
G
----
E
G
R
G
Y
V
D
M
S
T
V
D
P
A
T
S
Q
R
I
G
V
A
V
V
A
K
G
G
R
F
L
E
A
P
V
S
G
S
K
K
P
A
E
D
G
T
L
I
I
L
A
A
G
D
R
N
L
Y
D
E
A
M
P
G
F
E
K
M
G
K
K
I
I
------
H
L
G
D
-
V
G
K
G
A
E
M
K
L
V
V
N
M
V
M
G
G
M
M
A
C
F
C
E
G
L
A
L
G
E
K
A
G
L
A
T
D
A
I
L
D
V
I
G
A
G
A
M
A
N
P
M
F
A
--
L
K
G
-
G
--
L
-------
I
R
-----
D
R
-----
N
F
A
P
A
F
P
L
K
H
M
Q
K
D
L
R
L
A
V
A
L
G
D
R
V
G
Q
P
L
V
A
--
S
A
A
A
N
E
L
F
K
G
A
R
A
A
G
F
G
D
E
D
F
S
A
I
F
K
T
Y
--
38
HHSearch
74.54
30%
-107
- C1 -
3PEF
6
?
A:
[1-286]
-
S
Q
K
F
G
F
I
G
L
G
I
M
G
S
A
M
A
K
N
L
V
K
A
G
C
S
V
T
I
W
N
R
S
P
E
K
A
E
E
L
A
A
-
L
-
G
A
E
R
A
A
T
P
C
E
V
V
E
S
C
P
V
--------
T
F
A
M
L
--
A
D
P
A
A
A
E
E
V
C
F
G
K
H
G
V
L
E
G
I
G
----
E
G
R
G
Y
V
D
M
S
T
V
D
P
A
T
S
Q
R
I
G
V
A
V
V
A
K
G
G
R
F
L
E
A
P
V
S
G
S
K
K
P
A
E
D
G
T
L
I
I
L
A
A
G
D
R
N
L
Y
D
E
A
M
P
G
F
E
K
M
G
K
K
I
I
------
H
L
G
D
-
V
G
K
G
A
E
M
K
L
V
V
N
M
V
M
G
G
M
M
A
C
F
C
E
G
L
A
L
G
E
K
A
G
L
A
T
D
A
I
L
D
V
I
G
A
G
A
M
A
N
P
M
F
A
--
L
K
G
-
G
--
L
-------
I
R
-----
D
R
-----
N
F
A
P
A
F
P
L
K
H
M
Q
K
D
L
R
L
A
V
A
L
G
D
R
V
G
Q
P
L
V
A
--
S
A
A
A
N
E
L
F
K
G
A
R
A
A
G
F
G
D
E
D
F
S
A
I
F
K
T
Y
E
-
42
HHSearch
73.78
24%
-132
- C1 -
3G0O
2
?
A:
[7-293]
-
D
F
H
V
G
I
V
G
L
G
S
M
G
M
G
A
A
R
S
C
L
R
A
G
L
S
T
W
G
A
D
L
N
P
Q
A
C
A
N
L
L
A
-
E
G
A
C
G
A
A
A
S
A
R
E
F
A
G
V
V
D
A
--------
L
V
I
L
V
--
V
N
A
A
Q
V
R
Q
V
L
F
--
D
G
V
A
H
L
M
K
----
P
G
S
A
V
M
V
S
S
T
I
S
S
A
D
A
Q
E
I
A
A
A
L
T
A
L
N
L
N
M
L
D
A
P
V
S
G
G
A
V
K
A
A
Q
G
E
M
T
V
M
A
S
G
S
E
A
A
F
T
R
L
K
P
V
L
D
A
V
A
S
N
V
Y
------
R
I
S
D
T
P
G
A
G
S
T
V
K
I
I
H
Q
L
L
A
G
V
H
I
A
A
A
A
E
A
M
A
L
A
A
R
A
G
I
P
L
D
V
M
Y
D
V
V
T
H
A
A
G
N
S
W
M
F
E
--
N
R
M
-
Q
--
H
-------
V
V
-----
D
G
-----
D
Y
T
P
R
S
A
V
D
I
F
V
K
D
L
G
L
V
A
D
T
A
K
A
L
R
F
P
L
P
L
--
A
S
T
A
L
N
M
F
T
S
A
S
N
A
G
Y
G
K
E
D
D
S
A
V
I
K
I
F
--
5
PsiBlast_PDB
73.48
35%
-131
- C1 -
1YB4
-
?
A:
[3-270]
----
L
G
F
I
G
L
G
I
M
G
S
P
M
A
I
N
L
A
R
A
G
H
Q
L
H
V
T
T
-
I
G
P
V
A
D
E
L
L
S
-
L
-
G
A
V
N
V
E
T
A
R
Q
V
T
E
F
A
D
I
--------
I
F
I
M
V
--
P
D
T
P
Q
V
E
D
V
L
F
G
E
H
G
C
A
K
T
S
L
----
Q
G
K
T
I
V
D
M
S
S
I
S
P
I
E
T
K
R
F
A
Q
R
V
N
E
M
G
A
D
Y
L
D
A
P
V
S
G
G
E
I
G
A
R
E
G
T
L
S
I
M
V
G
G
E
Q
K
V
F
D
R
V
K
P
L
F
D
I
L
G
K
N
I
T
------
L
V
G
G
-
N
G
D
G
Q
T
C
K
V
A
N
Q
I
I
V
A
L
N
I
E
A
V
S
E
A
L
V
F
A
S
K
A
G
A
D
P
V
R
V
R
Q
A
L
M
G
G
F
A
S
S
R
I
L
E
--
V
H
G
-
E
--
R
-------
M
I
-----
N
R
-----
T
F
E
P
G
F
K
I
A
L
H
Q
K
D
L
N
L
A
L
Q
S
A
K
A
L
A
L
N
L
P
N
--
T
A
T
C
Q
E
L
F
N
T
C
A
A
N
G
---------------
3
PsiBlast_PDB
72.82
38%
-126
- C1 -
3W6U
1
?
A:
[36-300]
-----------------
A
T
H
L
L
K
A
G
F
L
A
A
V
Y
N
R
T
R
E
K
T
K
P
F
A
E
-
A
-
G
V
Y
V
A
E
S
P
A
D
L
A
K
R
V
D
V
--------
V
I
V
M
V
--
S
D
A
P
D
V
E
Q
V
L
F
G
P
S
G
V
V
E
G
A
R
----
P
G
L
I
V
V
D
M
S
T
N
S
P
D
W
A
R
K
F
A
E
R
L
A
Q
Y
G
I
E
F
L
D
A
P
V
T
G
G
Q
K
G
A
I
E
G
T
L
T
I
M
V
G
G
K
E
E
L
F
H
R
L
L
P
I
F
K
A
M
G
R
D
I
V
------
Y
M
G
P
-
V
G
Y
G
Q
A
M
K
L
V
N
Q
V
V
V
A
L
N
T
V
A
M
V
E
G
L
K
L
A
K
A
L
G
L
D
M
D
K
V
A
E
V
L
T
R
----
S
G
A
I
E
--
L
Y
L
-
P
--
K
-------
L
L
-----
K
G
-----
D
L
S
P
G
F
K
A
E
H
L
K
K
D
L
G
Y
V
L
E
E
A
R
K
R
G
V
K
L
P
G
--
A
E
L
A
Y
E
L
Y
R
K
M
V
---
E
D
G
A
G
S
L
G
I
H
A
L
---
44
HHSearch
72.81
27%
-112
- C1 -
2UYY
2
GLYR1_HUMAN
A:
[30-315]
-
D
K
K
I
G
F
L
G
L
G
L
M
G
S
G
I
V
S
N
L
L
K
M
G
H
T
V
T
V
W
N
R
T
A
E
K
C
D
L
F
I
Q
-
E
-
G
A
R
L
G
R
T
P
A
E
V
V
S
T
C
D
I
--------
T
F
A
C
V
--
S
D
P
K
A
A
K
D
L
V
L
G
P
S
G
V
L
Q
G
I
R
----
P
G
K
C
Y
V
D
M
S
T
V
D
A
D
T
V
T
E
L
A
Q
V
I
V
S
R
G
G
R
F
L
E
A
P
V
S
G
N
Q
Q
L
S
N
D
G
M
L
V
I
L
A
A
G
D
R
G
L
Y
E
D
C
S
S
C
F
Q
A
M
G
K
T
S
F
------
F
L
G
E
-
V
G
N
A
A
K
M
M
L
I
V
N
M
V
Q
G
S
F
M
A
T
I
A
E
G
L
T
L
A
Q
V
T
G
Q
S
Q
Q
T
L
L
D
I
L
N
Q
G
Q
L
A
S
I
F
L
D
--
Q
K
C
-
Q
--
N
-------
I
L
-----
Q
G
-----
N
F
K
P
D
F
Y
L
K
Y
I
Q
K
D
L
R
L
A
I
A
L
G
D
A
V
N
H
P
T
P
M
--
A
A
A
A
N
E
V
Y
K
R
A
K
A
L
D
Q
S
D
N
D
M
S
A
V
Y
R
A
Y
I
-
10
PsiBlast_PDB
72.46
27%
-113
- C1 -
2UYY
2
GLYR1_HUMAN
A:
[31-315]
--
K
K
I
G
F
L
G
L
G
L
M
G
S
G
I
V
S
N
L
L
K
M
G
H
T
V
T
V
W
N
R
T
A
E
K
C
D
L
F
I
Q
-
E
-
G
A
R
L
G
R
T
P
A
E
V
V
S
T
C
D
I
--------
T
F
A
C
V
--
S
D
P
K
A
A
K
D
L
V
L
G
P
S
G
V
L
Q
G
I
R
----
P
G
K
C
Y
V
D
M
S
T
V
D
A
D
T
V
T
E
L
A
Q
V
I
V
S
R
G
G
R
F
L
E
A
P
V
S
G
N
Q
Q
L
S
N
D
G
M
L
V
I
L
A
A
G
D
R
G
L
Y
E
D
C
S
S
C
F
Q
A
M
G
K
T
S
F
------
F
L
G
E
-
V
G
N
A
A
K
M
M
L
I
V
N
M
V
Q
G
S
F
M
A
T
I
A
E
G
L
T
L
A
Q
V
T
G
Q
S
Q
Q
T
L
L
D
I
L
N
Q
G
Q
L
A
S
I
F
L
D
--
Q
K
C
-
Q
--
N
-------
I
L
-----
Q
G
-----
N
F
K
P
D
F
Y
L
K
Y
I
Q
K
D
L
R
L
A
I
A
L
G
D
A
V
N
H
P
T
P
M
--
A
A
A
A
N
E
V
Y
K
R
A
K
A
L
D
Q
S
D
N
D
M
S
A
V
Y
R
A
Y
I
-
53
HHSearch
72.42
32%
-106
* C1 *
4DLL
1
?
A:
[31-314]
-
A
R
K
I
T
F
L
G
T
G
S
M
G
L
P
M
A
R
R
L
C
E
A
G
Y
A
L
Q
V
W
N
R
T
P
A
R
A
A
S
L
A
A
-
L
-
G
A
T
I
H
E
Q
A
R
A
A
A
R
D
A
D
I
--------
V
V
S
M
L
--
E
N
G
A
V
V
Q
D
V
L
F
A
-
Q
G
V
A
A
A
M
K
----
P
G
S
L
F
L
D
M
A
S
I
T
P
R
E
A
R
D
H
A
A
R
L
G
A
L
G
I
A
H
L
D
T
P
V
S
G
G
T
V
G
A
E
Q
G
T
L
V
I
M
A
G
G
K
P
A
D
F
E
R
S
L
P
L
L
K
V
F
G
R
-
A
T
------
H
V
G
P
-
H
G
S
G
Q
L
T
K
L
A
N
Q
M
I
V
G
I
T
I
G
A
V
A
E
A
L
L
F
A
T
K
G
G
A
D
M
A
K
V
K
E
A
I
T
G
G
F
A
D
S
R
V
L
Q
--
L
H
G
-
Q
--
R
-------
M
V
-----
E
R
-----
D
F
A
P
R
A
R
L
S
I
Q
L
K
D
M
R
N
A
L
A
T
A
Q
E
I
G
F
D
A
P
I
--
T
G
L
F
E
Q
L
Y
A
E
G
V
E
H
G
L
T
D
L
D
Q
S
G
L
F
V
E
L
A
-
43
HHSearch
72.19
29%
-100
- C1 -
3DOJ
1
GLYR1_ARATH
A:
[20-306]
H
M
M
E
V
G
F
L
G
L
G
I
M
G
K
A
M
S
M
N
L
L
K
N
G
F
K
V
T
V
W
N
R
T
L
S
K
C
D
E
L
V
E
-
H
-
G
A
S
V
C
E
S
P
A
E
V
I
K
K
C
K
Y
--------
T
I
A
M
L
--
S
D
P
C
A
A
L
S
V
V
F
D
K
G
G
V
L
E
Q
I
C
----
E
G
K
G
Y
I
D
M
S
T
V
D
A
E
T
S
L
K
I
N
E
A
I
T
G
K
G
G
R
F
V
E
G
P
V
S
G
S
K
K
P
A
E
D
G
Q
L
I
I
L
A
A
G
D
K
A
L
F
E
E
S
I
P
A
F
D
V
L
G
K
R
S
F
------
Y
L
G
Q
-
V
G
N
G
A
K
M
K
L
I
V
N
M
I
M
G
S
M
M
N
A
F
S
E
G
L
V
L
A
D
K
S
G
L
S
S
D
T
L
L
D
I
L
D
L
G
A
M
T
N
P
M
F
K
--
G
K
G
-
P
--
S
-------
M
N
-----
K
S
-----
S
Y
P
P
A
F
P
L
K
H
Q
Q
K
D
M
R
L
A
L
A
L
G
D
E
N
A
V
S
M
P
V
--
A
A
A
A
N
E
A
F
K
K
A
R
S
L
G
L
G
D
L
D
F
S
A
V
I
E
A
V
K
-
48
HHSearch
71.96
33%
-114
- C- -
2GF2
-
3HIDH_HUMAN
A:
[40-331]
--
M
P
V
G
F
I
G
L
G
N
M
G
N
P
M
A
K
N
L
M
K
H
G
Y
P
L
I
I
Y
D
V
F
P
D
A
C
K
E
F
Q
D
-
A
-
G
E
Q
V
V
S
S
P
A
D
V
A
E
K
A
D
R
--------
I
I
T
M
L
--
P
T
S
I
N
A
I
E
A
Y
S
G
A
N
G
I
L
K
K
V
K
----
K
G
S
L
L
I
D
S
S
T
I
D
P
A
V
S
K
E
L
A
K
E
V
E
K
M
G
A
V
F
M
D
A
P
V
S
G
G
V
G
A
A
R
S
G
N
L
T
F
M
V
G
G
V
E
D
E
F
A
A
A
Q
E
L
L
G
C
M
G
S
N
V
V
------
Y
C
G
A
-
V
G
T
G
Q
A
A
K
I
C
N
N
M
L
L
A
I
S
M
I
G
T
A
E
A
M
N
L
G
I
R
L
G
L
D
P
K
L
L
A
K
I
L
N
M
S
S
G
R
C
W
S
S
D
--
T
Y
N
-
P
VP
G
-------
V
M
DGVPS
A
N
-----
N
Y
Q
G
G
F
G
T
T
L
M
A
K
D
L
G
L
A
Q
D
S
A
T
S
T
K
S
P
I
L
L
--
G
S
L
A
H
Q
I
Y
R
M
M
C
A
K
G
Y
S
K
K
D
F
S
S
V
F
Q
F
L
R
-
54
HHSearch
69.80
31%
-116
- C1 -
2CVZ
1
?
A:
[2-282]
--
E
K
V
A
F
I
G
L
G
A
M
G
Y
P
M
A
G
H
L
A
R
-
R
F
P
T
L
V
W
N
R
T
F
E
K
A
L
R
H
Q
E
E
F
-
G
S
E
--
A
V
P
L
E
R
V
A
E
A
R
V
--------
I
F
T
C
L
--
P
T
T
R
E
V
Y
E
V
A
E
A
---
L
Y
P
Y
L
R
----
E
G
T
Y
W
V
D
A
T
S
G
E
P
E
A
S
R
R
L
A
E
R
L
R
E
K
G
V
T
Y
L
D
A
P
V
S
G
G
T
S
G
A
E
A
G
T
L
T
V
M
L
G
G
P
E
E
A
V
E
R
V
R
P
F
L
A
Y
A
-
K
K
V
V
------
H
V
G
P
-
V
G
A
G
H
A
V
K
A
I
N
N
A
L
L
A
V
N
L
W
A
A
G
E
G
L
L
A
L
V
K
Q
G
V
S
A
E
K
A
L
E
V
I
N
A
S
S
G
R
S
N
A
T
E
--
N
L
I
P
Q
--
R
-------
V
L
-----
T
R
-----
A
F
P
K
T
F
A
L
G
L
L
V
K
D
L
G
I
A
M
G
V
L
D
G
E
K
A
P
S
P
L
--
L
R
L
A
R
E
V
Y
E
M
A
K
R
E
L
G
P
D
A
D
H
V
E
A
L
R
L
L
E
R
16
PsiBlast_PDB
66.17
34%
-130
- C1 -
3OBB
5
SERDH_PSEAE
A:
[4-252]
--
K
Q
I
A
F
I
G
L
G
H
M
G
A
P
M
A
T
N
L
L
K
A
G
Y
L
L
N
V
F
D
L
V
Q
S
A
V
D
G
L
V
A
-
A
-
G
A
S
A
A
R
S
A
R
D
A
V
Q
G
A
D
V
--------
V
I
S
M
L
--
P
A
S
Q
H
V
E
G
L
Y
L
D
D
D
G
L
L
A
H
I
A
----
P
-
T
L
V
L
E
C
S
T
I
A
P
T
S
A
R
K
I
H
A
A
A
R
E
R
G
L
A
M
L
D
A
P
V
S
G
G
T
A
G
A
A
A
G
T
L
T
F
M
V
G
G
D
A
E
A
L
E
K
A
R
P
L
F
E
A
M
G
R
N
I
F
------
H
A
G
P
-
D
G
A
G
Q
V
A
K
V
C
N
N
Q
L
L
A
V
L
M
I
G
T
A
E
A
M
A
L
G
V
A
N
G
L
E
A
K
V
L
A
E
I
M
R
R
S
S
G
G
N
W
A
L
E
VY
N
P
W
-
P
--
G
-------
V
M
-----
E
N
APASR
D
Y
S
G
G
F
M
A
Q
L
M
A
K
D
L
G
L
----------------------------------------------
25
PsiBlast_CBE
63.59
34%
-113
- C1 -
1WP4
2
?
C:
[4-261]
----
V
A
F
I
G
L
G
A
M
G
Y
P
M
A
G
H
-
L
A
R
R
F
P
T
L
V
W
N
R
T
F
E
K
A
---
L
R
-
H
-
Q
E
E
F
G
S
E
A
V
P
L
E
R
V
A
E
A
--------
R
V
I
F
T
--
C
L
P
T
-
T
R
E
V
Y
E
V
A
E
A
L
Y
P
Y
L
R
----
E
G
T
Y
W
V
D
A
T
S
G
E
P
E
A
S
R
R
L
A
E
R
L
R
E
K
G
V
T
Y
L
D
A
P
V
S
G
G
T
S
G
A
E
A
G
T
L
T
V
M
L
G
G
P
E
E
A
V
E
R
V
R
P
-
F
L
A
Y
A
K
K
V
V
------
H
V
G
P
-
V
G
A
G
H
A
V
K
A
I
N
N
A
L
L
A
V
N
L
W
A
A
G
E
G
L
L
A
L
V
K
Q
G
V
S
A
E
K
A
L
E
V
I
N
A
S
S
G
R
S
N
A
T
E
--
N
L
I
-
P
Q-
R
-------
V
L
-----
T
R
-----
A
F
P
K
T
F
A
L
G
L
L
V
K
D
L
G
I
A
M
--
G
V
L
D
G
E
K
A
P
S
PL
L
R
L
A
R
E
V
Y
E
---------------------
24
PsiBlast_CBE
63.26
34%
-119
- C1 -
1WP4
3
?
D:
[4-261]
----
V
A
F
I
G
L
G
A
M
G
Y
P
M
A
G
H
-
L
A
R
R
F
P
T
L
V
W
N
R
T
F
E
K
A
---
L
R
-
H
-
Q
E
E
F
G
S
E
A
V
P
L
E
R
V
A
E
A
--------
R
V
I
F
T
--
C
L
P
T
-
T
R
E
V
Y
E
V
A
E
A
L
Y
P
Y
L
R
----
E
G
T
Y
W
V
D
A
T
S
G
E
P
E
A
S
R
R
L
A
E
R
L
R
E
K
G
V
T
Y
L
D
A
P
V
S
G
G
T
S
G
A
E
A
G
T
L
T
V
M
L
G
G
P
E
E
A
V
E
R
V
R
P
-
F
L
A
Y
A
K
K
V
V
------
H
V
G
P
-
V
G
A
G
H
A
V
K
A
I
N
N
A
L
L
A
V
N
L
W
A
A
G
E
G
L
L
A
L
V
K
Q
G
V
S
A
E
K
A
L
E
V
I
N
A
S
S
G
R
S
N
A
T
E
--
N
L
I
-
P
Q-
R
-------
V
L
-----
T
R
-----
A
F
P
K
T
F
A
L
G
L
L
V
K
D
L
G
I
A
M
--
G
V
L
D
G
E
K
A
P
S
PL
L
R
L
A
R
E
V
Y
E
---------------------
26
PsiBlast_CBE
62.95
34%
-109
- C1 -
1WP4
3
?
B:
[4-261]
----
V
A
F
I
G
L
G
A
M
G
Y
P
M
A
G
H
-
L
A
R
R
F
P
T
L
V
W
N
R
T
F
E
K
A
---
L
R
-
H
-
Q
E
E
F
G
S
E
A
V
P
L
E
R
V
A
E
A
--------
R
V
I
F
T
--
C
L
P
T
-
T
R
E
V
Y
E
V
A
E
A
L
Y
P
Y
L
R
----
E
G
T
Y
W
V
D
A
T
S
G
E
P
E
A
S
R
R
L
A
E
R
L
R
E
K
G
V
T
Y
L
D
A
P
V
S
G
G
T
S
G
A
E
A
G
T
L
T
V
M
L
G
G
P
E
E
A
V
E
R
V
R
P
-
F
L
A
Y
A
K
K
V
V
------
H
V
G
P
-
V
G
A
G
H
A
V
K
A
I
N
N
A
L
L
A
V
N
L
W
A
A
G
E
G
L
L
A
L
V
K
Q
G
V
S
A
E
K
A
L
E
V
I
N
A
S
S
G
R
S
N
A
T
E
--
N
L
I
-
P
Q-
R
-------
V
L
-----
T
R
-----
A
F
P
K
T
F
A
L
G
L
L
V
K
D
L
G
I
A
M
--
G
V
L
D
G
E
K
A
P
S
P
L
L
R
L
A
R
E
V
Y
E
---------------------
20
PsiBlast_PDB
45.36
33%
-93
- C1 -
2W90
1
?
A:
[5-201]
-
K
H
Q
I
G
V
I
G
L
A
V
M
G
K
N
L
A
L
N
I
E
S
K
G
Y
S
V
A
V
Y
N
R
L
R
E
K
T
D
E
F
L
Q
-
E
--
A
K
G
K
N
I
V
G
T
Y
S
I
E
E
F
V
N
A
LEKP
R
K
I
L
L
M
V
KA
G
A
P
T
D
---------
A
T
I
E
Q
L
K
PHLE
K
G
D
I
V
I
D
G
G
N
T
Y
F
K
D
T
Q
R
R
N
K
E
L
A
E
L
G
I
H
F
I
G
T
G
V
S
G
G
E
E
G
A
L
K
G
P
-
S
I
M
P
G
G
Q
K
E
A
H
E
L
V
R
P
I
F
E
A
I
A
A
K
V
D
GEPCTT
Y
I
G
P
-
D
G
A
G
H
Y
V
K
M
V
H
N
G
I
E
Y
G
D
M
Q
L
I
A
E
A
---------------------------------------------------------------------------------------------------------------------------
29
PsiBlast_CBE
44.92
33%
-91
- C1 -
2W8Z
1
?
A:
[4-200]
-
K
H
Q
I
G
V
I
G
L
A
V
M
G
K
N
L
A
L
N
I
E
S
K
G
Y
S
V
A
V
Y
N
R
L
R
E
K
T
D
E
F
L
Q
-
E
--
A
K
G
K
N
I
V
G
T
Y
S
I
E
E
F
V
N
A
LEKP
R
K
I
L
L
M
V
KA
G
A
P
T
D
---------
A
T
I
E
Q
L
K
PHLE
K
G
D
I
V
I
D
G
G
N
T
Y
F
K
D
T
Q
R
R
N
K
E
L
A
E
L
G
I
H
F
I
G
T
G
V
S
G
G
E
E
G
A
L
K
G
P
-
S
I
M
P
G
G
Q
K
E
A
H
E
L
V
R
P
I
F
E
A
I
A
A
K
V
D
GEPCTT
Y
I
G
P
-
D
G
A
G
H
Y
V
K
M
V
H
N
G
I
E
Y
G
D
M
Q
L
I
A
E
A
---------------------------------------------------------------------------------------------------------------------------
28
PsiBlast_CBE
44.74
33%
-94
- C1 -
2W8Z
1
?
B:
[4-200]
-
K
H
Q
I
G
V
I
G
L
A
V
M
G
K
N
L
A
L
N
I
E
S
K
G
Y
S
V
A
V
Y
N
R
L
R
E
K
T
D
E
F
L
Q
-
E
--
A
K
G
K
N
I
V
G
T
Y
S
I
E
E
F
V
NALEKPRK
I
L
L
M
V
KA
G
A
P
T
D
---------
A
T
I
E
Q
L
K
PHLE
K
G
D
I
V
I
D
G
G
N
T
Y
F
K
D
T
Q
R
R
N
K
E
L
A
E
L
G
I
H
F
I
G
T
G
V
S
G
G
E
E
G
A
L
K
G
P
-
S
I
M
P
G
G
Q
K
E
A
H
E
L
V
R
P
I
F
E
A
I
A
A
K
V
D
GEPCTT
Y
I
G
P
-
D
G
A
G
H
Y
V
K
M
V
H
N
G
I
E
Y
G
D
M
Q
L
I
A
E
A
---------------------------------------------------------------------------------------------------------------------------