@TOME V2.3
(Nov 2016)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : bsu14610: (2016-06-22 )
MVVGDFPIETDTLVIGAGPGGYVAAIRAAQLGQKVTVVEKATLGGVCLNVGCIPSKALINAGHRYENAKHSDDMGITAENVTVDFTKVQEWKASVVNKLTGGVAGLLKGNKVDVVKGEAYFVDSNSVRVMDENSAQTYTFKNAIIATGSRPIELPNFKYSERVLNSTGALALKEIPKKLVVIGGGYIGTELGTAYANFGTELVILEGGDEILPGFEKQMSSLVTRRLKKKGNVEIHTNAMAKGVEERPDGVTVTFEVKGEEKTVDADYVLITVGRRPNTDELGLEQVGIEMTDRGIVKTDKQCRTNVPNIYAIGDIIEGPPLAHKASYEGKIAAEAIAGEPAEIDYLGIPAVVFSEPELASVGYTEAQAKEEGLDIVAAKFPFAANGRALSLNETDGFMKLITRKEDGLVIGAQIAGASASDMISELSLAIEGGMTAEDIAMTIHAHPTLGEITMEAAEVAIGSPIHIVK
Atome Classification :
(54 SA)
.........10.........20........30........40------.------.-.......50........-60..-......-70.-.---.---.-...-.-.-80........90........100-......--.110........120.---------......------130.-----------.-------..-.-------.-----..140.......150--......--.---160-.-----.--.-.....170.-.-.--....180.......190.......200.......210.......220.......230-........240.....-..250.....-.--.--.---.---260.......270.......280.......290.......300.......310...---...-.-320........330...-....340-..-----.....----.350.......360.......370.-.-.--....-380.......390.......400.......410.......-420.......430.......440......---.450--.......460.......470
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MVVGDFPIET-D
T
L
V
I
GAGPG
G
Y
V
A
A
I
R
A
A
QLG
Q
K
V
T
V
V
E
K-------A------T-LG
G
V
C
L
NVGCI
P
S
K
A
L
I-NAGH-RYENAK-H-S-D---D---M-
G
I
T
-A-E-
N
V
T
V
D
F
T
K
V
Q
E
W
K
A
S
V
V
N
K
L
T
G
G
-
V
A
G
LLK--GN
K
-
V
D
V
VKG
E
A
Y
F
VD---------SN
S
V
R
V
------MD-E-----------N-------SA-
Q
-------
T
-----
Y
T
F
K
N
A
I
IATGSRPI--ELPN
F
K
--
Y
---
S
-
E
-
R
-----
V
--
L
-NSTG
A
L
A
L
K
-E-I--PK
K
L
V
V
IGG
G
Y
IG
T
E
L
G
T
A
Y
ANFG
T
E
L
V
I
LEGGDEIL
P
G
F
E
K
Q
M
S
S
L
V
T
R
R
L
KKK-G-
N
V
E
I
H
T
N
A
M
AKGVEER-PD
G
--
V
T
V
T
F
-
E
--V--K---G---EEKTVDA
D
Y
V
L
I
T
VGRRPNTDEL
G
L
E
Q
VGIEMTDRGIVKTD
K
Q
CRTNVP
N
I
Y
A
IGD---IIE-G-P-PLAHKASYEG
K
I
A
A
E
-AIAGEP--A
E
-----
I
D
YLG----I
P
A
V
VFSEPELASVGYT
E
A
Q
AKEEG-
L
-
D
--
I
V
A
A-KFPFAAN
G
R
A
L
S
LNETD
G
F
M
K
L
I
TRKED
G
L
V
I
G
A
Q
IAGA
S
-
A
S
D
M
I
S
E
L
S
L
A
IEGGM
T
A
E
D
I
A
M
T
I
HAHP---T
L
G
E
--
I
T
M
E
A
A
E
V
AIGSP
I
H
IVK
21
PsiBlast_CBE
96.07
78%
-115
- C2 -
1EBD
2
DLDH1_GEOSE
B:
[2-455]
-------
I
E
T
-
E
T
L
V
V
G
A
G
P
G
G
Y
V
A
A
I
R
A
A
Q
L
G
Q
K
V
T
I
V
E
K
-------
G
------
N
-
L
G
G
V
C
L
N
V
G
C
I
P
S
K
A
L
I
-
S
A
S
H
-
R
Y
E
Q
A
K
-
H
-
S
-
E
---
E
---
M
-
G
I
K
-
A
-
E
-
N
V
T
I
D
F
A
K
V
Q
E
W
K
A
S
V
V
K
K
L
T
G
G
-
V
E
G
L
L
K
--
G
N
K
-
V
E
I
V
K
G
E
A
Y
F
V
D
---------
A
N
T
V
R
V
------
V
N
-
G
-----------
D
-------
S
A
-
Q
-------
T
-----
Y
T
F
K
N
A
I
I
A
T
G
S
R
P
I
--
E
L
P
N
F
K
--
F
---
S
-
N
-
R
-----
I
--
L
-
D
S
T
G
A
L
N
L
G
-
E
-
V
--
P
K
S
L
V
V
I
G
G
G
Y
I
G
I
E
L
G
T
A
Y
A
N
F
G
T
K
V
T
I
L
E
G
A
G
E
I
L
S
G
F
E
K
Q
M
A
A
I
I
K
K
R
L
K
K
K
-
G
--
V
E
V
V
T
N
A
L
A
K
G
A
E
E
R
-
E
D
G
--
V
T
V
T
Y
-
E
--
A
--
N
---
G
---
E
T
K
T
I
D
A
D
Y
V
L
V
T
V
G
R
R
P
N
T
D
E
L
G
L
E
Q
I
G
I
K
M
T
N
R
G
L
I
E
V
D
Q
Q
C
R
T
S
V
P
N
I
F
A
I
G
D
---
I
V
P
-
G
-
P
-
A
L
A
H
K
A
S
Y
E
G
K
V
A
A
E
-
A
I
A
G
H
P
--
S
A
-----
V
D
Y
V
A
----
I
P
A
V
V
F
S
D
P
E
C
A
S
V
G
Y
F
E
Q
Q
A
K
D
E
G
-
I
-
D
--
V
I
A
A
-
K
F
P
F
A
A
N
G
R
A
L
A
L
N
D
T
D
G
F
L
K
L
V
V
R
K
E
D
G
V
I
I
G
A
Q
I
I
G
P
N
-
A
S
D
M
I
A
E
L
G
L
A
I
E
A
G
M
T
A
E
D
I
A
L
T
I
H
A
H
P
---
T
L
G
E
--
I
A
M
E
A
A
E
V
A
L
--------
1
PsiBlast_PDB
95.69
78%
-117
- C2 -
1EBD
2
DLDH1_GEOSE
A:
[2-455]
-------
I
E
T
-
E
T
L
V
V
G
A
G
P
G
G
Y
V
A
A
I
R
A
A
Q
L
G
Q
K
V
T
I
V
E
K
-------
G
------
N
-
L
G
G
V
C
L
N
V
G
C
I
P
S
K
A
L
I
-
S
A
S
H
-
R
Y
E
Q
A
K
-
H
-
S
-
E
---
E
---
M
-
G
I
K
-
A
-
E
-
N
V
T
I
D
F
A
K
V
Q
E
W
K
A
S
V
V
K
K
L
T
G
G
-
V
E
G
L
L
K
--
G
N
K
-
V
E
I
V
K
G
E
A
Y
F
V
D
---------
A
N
T
V
R
V
------
V
N
-
G
-----------
D
-------
S
A
-
Q
-------
T
-----
Y
T
F
K
N
A
I
I
A
T
G
S
R
P
I
--
E
L
P
N
F
K
--
F
---
S
-
N
-
R
-----
I
--
L
-
D
S
T
G
A
L
N
L
G
-
E
-
V
--
P
K
S
L
V
V
I
G
G
G
Y
I
G
I
E
L
G
T
A
Y
A
N
F
G
T
K
V
T
I
L
E
G
A
G
E
I
L
S
G
F
E
K
Q
M
A
A
I
I
K
K
R
L
K
K
K
-
G
--
V
E
V
V
T
N
A
L
A
K
G
A
E
E
R
-
E
D
G
--
V
T
V
T
Y
-
E
--
A
--
N
---
G
---
E
T
K
T
I
D
A
D
Y
V
L
V
T
V
G
R
R
P
N
T
D
E
L
G
L
E
Q
I
G
I
K
M
T
N
R
G
L
I
E
V
D
Q
Q
C
R
T
S
V
P
N
I
F
A
I
G
D
---
I
V
P
-
G
-
P
-
A
L
A
H
K
A
S
Y
E
G
K
V
A
A
E
-
A
I
A
G
H
P
--
S
A
-----
V
D
Y
V
A
----
I
P
A
V
V
F
S
D
P
E
C
A
S
V
G
Y
F
E
Q
Q
A
K
D
E
G
-
I
-
D
--
V
I
A
A
-
K
F
P
F
A
A
N
G
R
A
L
A
L
N
D
T
D
G
F
L
K
L
V
V
R
K
E
D
G
V
I
I
G
A
Q
I
I
G
P
N
-
A
S
D
M
I
A
E
L
G
L
A
I
E
A
G
M
T
A
E
D
I
A
L
T
I
H
A
H
P
---
T
L
G
E
--
I
A
M
E
A
A
E
V
A
L
--------
135
HHSearch
95.41
78%
-117
- C2 -
1EBD
2
DLDH1_GEOSE
A:
[2-454]
-------
I
E
T
-
E
T
L
V
V
G
A
G
P
G
G
Y
V
A
A
I
R
A
A
Q
L
G
Q
K
V
T
I
V
E
K
-------
G
------
N
-
L
G
G
V
C
L
N
V
G
C
I
P
S
K
A
L
I
-
S
A
S
H
-
R
Y
E
Q
A
K
-
H
-
S
-
E
---
E
---
M
-
G
I
K
-
A
-
E
-
N
V
T
I
D
F
A
K
V
Q
E
W
K
A
S
V
V
K
K
L
T
G
G
-
V
E
G
L
L
K
--
G
N
K
-
V
E
I
V
K
G
E
A
Y
F
V
D
---------
A
N
T
V
R
V
------
V
N
-
G
-----------
D
-------
S
A
-
Q
-------
T
-----
Y
T
F
K
N
A
I
I
A
T
G
S
R
P
I
--
E
L
P
N
F
K
--
F
---
S
-
N
-
R
-----
I
--
L
-
D
S
T
G
A
L
N
L
G
-
E
-
V
--
P
K
S
L
V
V
I
G
G
G
Y
I
G
I
E
L
G
T
A
Y
A
N
F
G
T
K
V
T
I
L
E
G
A
G
E
I
L
S
G
F
E
K
Q
M
A
A
I
I
K
K
R
L
K
K
--
K
-
G
V
E
V
V
T
N
A
L
A
K
G
A
E
E
R
-
E
D
G
--
V
T
V
T
Y
-
E
--
A
--
N
---
G
---
E
T
K
T
I
D
A
D
Y
V
L
V
T
V
G
R
R
P
N
T
D
E
L
G
L
E
Q
I
G
I
K
M
T
N
R
G
L
I
E
V
D
Q
Q
C
R
T
S
V
P
N
I
F
A
I
G
D
---
I
V
P
-
G
-
P
-
A
L
A
H
K
A
S
Y
E
G
K
V
A
A
E
-
A
I
A
G
H
P
--
S
A
-----
V
D
Y
V
A
----
I
P
A
V
V
F
S
D
P
E
C
A
S
V
G
Y
F
E
Q
Q
A
K
D
E
G
-
I
-
D
--
V
I
A
A
-
K
F
P
F
A
A
N
G
R
A
L
A
L
N
D
T
D
G
F
L
K
L
V
V
R
K
E
D
G
V
I
I
G
A
Q
I
I
G
P
N
-
A
S
D
M
I
A
E
L
G
L
A
I
E
A
G
M
T
A
E
D
I
A
L
T
I
H
A
H
P
---
T
L
G
E
--
I
A
M
E
A
A
E
V
A
---------
112
Fugue
89.19
73%
-119
- C2 -
1EBD
2
DLDH1_GEOSE
A:
[1-455]
------
A
I
E
T
-
E
T
L
V
V
G
A
G
P
G
G
Y
V
A
A
I
R
A
A
Q
L
G
Q
K
V
T
I
V
E
K
-------
G
-------N
L
G
G
V
C
L
N
V
G
C
I
P
S
K
A
L
I
-
S
A
S
H
-
R
Y
E
Q
A
K
-
H
---
S
---
E
EMG
I
-
K
A
E
-----
N
V
T
I
D
F
A
K
V
Q
E
W
K
A
S
V
V
K
K
L
T
G
G
-
V
E
G
L
L
K
G
N
K
-
V
-
E
I
V
K
-
G
E
A
Y
F
V
-DAN
T
V
R
V
V
N
---------------
G
-----------
D
-------
S
A
-
Q
-------
T
-----
Y
T
F
K
N
A
I
I
A
T
G
S
R
P
I
--
E
L
P
N
F
K
--
F
---
S
----NRILD------
S
T
G
A
L
N
L
G
----EV
P
K
S
L
V
V
I
G
G
G
Y
I
G
I
E
L
G
T
A
Y
A
N
F
G
T
K
V
T
I
L
E
G
A
G
E
I
L
S
G
F
E
K
Q
M
A
A
I
I
K
K
R
L
K
K
K
-
G
--
V
E
V
V
T
N
A
L
A
K
G
A
E
E
R
-
E
-
D
--
G
V
T
V
T
-
Y
--
E
--
A
---
N
G
E
T
-
K
T
I
D
-
A
D
Y
V
L
V
T
V
G
R
R
P
N
T
D
E
L
G
L
E
Q
I
G
I
K
M
T
N
R
G
L
I
E
V
D
Q
Q
C
R
T
S
V
P
N
I
F
A
I
G
D
---
I
V
P
-
G
--P
A
L
A
H
K
A
S
Y
E
G
K
V
A
A
E
-
A
I
A
G
------HPSAV
D
Y
V
A
I
----
P
A
V
V
F
S
D
-
P
E
C
A
S
V
G
Y
F
E
Q
Q
A
K
D
E
G
-
I
-
D
--
V
I
A
A
-
K
F
P
F
A
A
N
G
R
A
L
A
L
N
D
T
D
G
F
L
K
L
V
V
R
K
E
D
G
V
I
I
G
A
Q
I
I
G
-
P
N
A
S
D
M
I
A
E
L
G
L
A
I
E
A
G
M
T
A
E
D
I
A
L
T
--
I
H
A
H
PT-
L
G
E
--
I
A
M
E
A
A
E
V
A
L
--------
15
PsiBlast_PDB
80.20
41%
-126
- C2 -
1LVL
2
DLDH1_PSEPU
A:
[4-458]
-------
I
Q
T
-
T
L
L
I
I
G
G
G
P
G
G
Y
V
A
A
I
R
A
G
Q
L
G
I
P
T
V
L
V
E
G
-------
Q
------
A
-
L
G
G
T
C
L
N
I
G
C
I
P
S
K
A
L
I
-
H
V
A
E
-
Q
F
H
Q
A
S
-
R
-
F
-
T
---
E
PSP
L
-
G
I
S
-
V
-
A
-
S
P
R
L
D
I
G
Q
S
V
A
W
K
D
G
I
V
D
R
L
T
T
G
-
V
A
A
L
L
K
--
K
H
G
-
V
K
V
V
H
G
W
A
K
V
L
D
---------
G
K
Q
V
E
V
-----------------------------
D
G
-
Q
-------
R
-----
I
Q
C
E
H
L
L
L
A
T
G
S
S
S
V
--
E
L
P
M
L
P
--
L
---
G
-
G
-
P
-----
V
--
I
-
S
S
T
E
A
L
A
P
K
-
A
-
L
--
P
Q
H
L
V
V
V
G
G
G
Y
I
G
L
E
L
G
I
A
Y
R
K
L
G
A
Q
V
S
V
V
E
A
R
E
R
I
L
P
T
Y
D
S
E
L
T
A
P
V
A
E
S
L
K
K
L
-
G
--
I
A
L
H
L
G
H
S
V
E
G
Y
E
----
N
G
--
C
L
L
A
N
-
D
--
G
--
K
---
G
---
G
Q
L
R
L
E
A
D
R
V
L
V
A
V
G
R
R
P
R
T
K
G
F
N
L
E
C
L
D
L
K
M
N
G
A
A
I
A
-
I
D
E
R
C
Q
T
S
M
H
N
V
W
A
I
G
D
---
V
A
G
-
E
-
P
-
M
L
A
H
R
A
M
A
Q
G
E
M
V
A
E
-
I
I
A
G
K
A
--
R
R
-----
F
E
P
A
A
----
I
A
A
V
C
F
T
D
P
E
V
V
V
V
G
K
T
P
E
Q
A
S
Q
Q
G
-
L
-
D
--
C
I
V
A
-
Q
F
P
F
A
A
N
G
R
A
M
S
L
E
S
K
S
G
F
V
R
V
V
A
R
R
D
N
H
L
I
L
G
W
Q
A
V
G
V
A
-
V
S
E
L
S
T
A
F
A
Q
S
L
E
M
G
A
C
L
E
D
V
A
G
T
I
H
A
H
P
---
T
L
G
E
--
A
V
Q
E
A
A
L
R
A
L
G
H
A
L
H
I
--
22
PsiBlast_CBE
79.83
47%
-107
- C2 -
4JQ9
19
?
F:
[5-462]
-------
I
K
T
-
Q
V
V
V
L
G
A
G
P
A
G
Y
S
A
A
F
R
C
A
D
L
G
L
E
T
V
I
V
E
R
-------
Y
N-----
T
-
L
G
G
V
C
L
N
V
G
C
I
P
S
K
A
L
L
-
H
V
A
K
-
V
I
E
E
A
K
-
A
-
L
-
A
---
E
---
H
-
G
I
V
-
F
-
G
-
E
P
K
T
D
I
D
K
I
R
T
W
K
E
K
V
I
N
Q
L
T
G
G
-
L
A
G
M
A
K
--
G
R
K
-
V
K
V
V
N
G
L
G
K
F
T
G
---------
A
N
T
L
E
V
------
E
G
-
E
-----------
N
-------
G
K
-
T
-------
V
-----
I
N
F
D
N
A
I
I
A
A
G
S
R
P
I
--
Q
L
P
F
I
P
--
H
---
E
-
D
P
R
-----
I
--
W
-
D
S
T
D
A
L
E
L
K
-
E
-
V
--
P
E
R
L
L
V
M
G
G
G
I
I
G
L
E
M
G
T
V
Y
H
A
L
G
S
Q
I
D
V
V
E
M
F
D
Q
V
I
P
A
A
D
K
D
I
V
K
V
F
T
K
R
I
S
K
K
-
F
-
N
L
M
L
E
T
K
V
T
A
--
V
E
A
K
-
E
D
G
--
I
Y
V
T
M
-
E
--
G
--
K
KAP
A
---
E
P
Q
R
Y
D
A
--
V
L
V
A
I
G
R
V
P
N
G
K
N
L
D
A
G
K
A
G
V
E
V
D
D
R
G
F
I
R
V
D
K
Q
L
R
T
N
V
P
H
I
F
A
I
G
D
---
I
V
G
-
Q
-
P
-
M
L
A
H
K
G
V
H
E
G
H
V
A
A
E
-
V
I
A
G
K
K
--
H
Y
-----
F
D
P
K
V
----
I
P
S
I
A
Y
T
E
P
E
V
A
W
V
G
L
T
E
K
E
A
K
E
K
G
-
I
-
S
--
Y
E
T
A
-
T
F
P
W
A
A
S
G
R
A
I
A
S
D
C
A
D
G
M
T
K
L
I
F
D
K
E
S
H
R
V
I
G
G
A
I
V
G
T
N
-
G
G
E
L
L
G
E
I
G
L
A
I
E
M
G
C
D
A
E
D
I
A
L
T
I
H
A
H
P
---
T
L
H
E
--
S
V
G
L
A
A
E
V
F
E
G
S
------
122
HHSearch
79.79
42%
-125
- C2 -
1LVL
2
DLDH1_PSEPU
A:
[1-458]
----
Q
Q
T
I
Q
T
-
T
L
L
I
I
G
G
G
P
G
G
Y
V
A
A
I
R
A
G
Q
L
G
I
P
T
V
L
V
E
G
-------
Q
------
A
-
L
G
G
T
C
L
N
I
G
C
I
P
S
K
A
L
I
-
H
V
A
E
-
Q
F
H
Q
A
S
-
R
-
F
-
T
E
PS
P
---
L
-
G
I
S
-
V
-
A
-
S
P
R
L
D
I
G
Q
S
V
A
W
K
D
G
I
V
D
R
L
T
T
G
-
V
A
A
L
L
K
--
K
H
G
-
V
K
V
V
H
G
W
A
K
V
L
D
---------
G
K
Q
V
E
V
------
D
-----------------------
G
-
Q
-------
R
-----
I
Q
C
E
H
L
L
L
A
T
G
S
S
S
V
--
E
L
P
-
M
L
--
P
L--
G
-
G
-
P
-----
V
--
I
-
S
S
T
E
A
L
A
P
K
-
A
-
L
--
P
Q
H
L
V
V
V
G
G
G
Y
I
G
L
E
L
G
I
A
Y
R
K
L
G
A
Q
V
S
V
V
E
A
R
E
R
I
L
P
T
Y
D
S
E
L
T
A
P
V
A
E
S
L
K
K
--
L
-
G
I
A
L
H
L
G
H
S
V
E
G
Y
E
N
G
-------
C
L
L
A
-
N
--
D
--
G
K--
G
---
G
Q
L
R
L
E
A
D
R
V
L
V
A
V
G
R
R
P
R
T
K
G
F
N
L
E
C
L
D
L
K
M
N
-
G
A
A
I
A
I
D
E
R
C
Q
T
S
M
H
N
V
W
A
I
G
D
---
V
A
G
-
E
-
P
-
M
L
A
H
R
A
M
A
Q
G
E
M
V
A
E
-
I
I
A
G
K
A
--
R
R
-----
F
E
P
A
A
----
I
A
A
V
C
F
T
D
P
E
V
V
V
V
G
K
T
P
E
Q
A
S
Q
Q
G
-
L
-
D
--
C
I
V
A
-
Q
F
P
F
A
A
N
G
R
A
M
S
L
E
S
K
S
G
F
V
R
V
V
A
R
R
D
N
H
L
I
L
G
W
Q
A
V
G
V
A
-
V
S
E
L
S
T
A
F
A
Q
S
L
E
M
G
A
C
L
E
D
V
A
G
T
I
H
A
H
P
---
T
L
G
E
--
A
V
Q
E
A
A
L
R
A
L
G
H
A
L
H
I
--
3
PsiBlast_PDB
79.73
47%
-110
- C2 -
4JQ9
14
?
A:
[5-462]
-------
I
K
T
-
Q
V
V
V
L
G
A
G
P
A
G
Y
S
A
A
F
R
C
A
D
L
G
L
E
T
V
I
V
E
R
-------
Y
N-----
T
-
L
G
G
V
C
L
N
V
G
C
I
P
S
K
A
L
L
-
H
V
A
K
-
V
I
E
E
A
K
-
A
-
L
-
A
---
E
---
H
-
G
I
V
-
F
-
G
-
E
P
K
T
D
I
D
K
I
R
T
W
K
E
K
V
I
N
Q
L
T
G
G
-
L
A
G
M
A
K
--
G
R
K
-
V
K
V
V
N
G
L
G
K
F
T
G
---------
A
N
T
L
E
V
------
E
G
-
E
-----------
N
-------
G
K
-
T
-------
V
-----
I
N
F
D
N
A
I
I
A
A
G
S
R
P
I
--
Q
L
P
F
I
P
--
H
---
E
-
D
P
R
-----
I
--
W
-
D
S
T
D
A
L
E
L
K
-
E
-
V
--
P
E
R
L
L
V
M
G
G
G
I
I
G
L
E
M
G
T
V
Y
H
A
L
G
S
Q
I
D
V
V
E
M
F
D
Q
V
I
P
A
A
D
K
D
I
V
K
V
F
T
K
R
I
S
K
K
-
F
-
N
L
M
L
E
T
K
V
T
A
--
V
E
A
K
-
E
D
G
--
I
Y
V
T
M
-
E
--
G
--
K
KAP
A
---
E
P
Q
R
Y
D
A
--
V
L
V
A
I
G
R
V
P
N
G
K
N
L
D
A
G
K
A
G
V
E
V
D
D
R
G
F
I
R
V
D
K
Q
L
R
T
N
V
P
H
I
F
A
I
G
D
---
I
V
G
-
Q
-
P
-
M
L
A
H
K
G
V
H
E
G
H
V
A
A
E
-
V
I
A
G
K
K
--
H
Y
-----
F
D
P
K
V
----
I
P
S
I
A
Y
T
E
P
E
V
A
W
V
G
L
T
E
K
E
A
K
E
K
G
-
I
-
S
--
Y
E
T
A
-
T
F
P
W
A
A
S
G
R
A
I
A
S
D
C
A
D
G
M
T
K
L
I
F
D
K
E
S
H
R
V
I
G
G
A
I
V
G
T
N
-
G
G
E
L
L
G
E
I
G
L
A
I
E
M
G
C
D
A
E
D
I
A
L
T
I
H
A
H
P
---
T
L
H
E
--
S
V
G
L
A
A
E
V
F
E
G
S
------
17
PsiBlast_PDB
79.67
43%
-112
- C2 -
2YQU
4
?
A:
[3-455]
-----------
D
L
L
V
I
G
A
G
P
G
G
Y
V
A
A
I
R
A
A
Q
L
G
M
K
V
G
V
V
E
K
E------
K
------
A
-
L
G
G
T
C
L
R
V
G
C
I
P
S
K
A
L
L
-
E
T
T
E
-
R
I
Y
E
A
K
---
K
-
G
---
L
---
L
-
G
A
K
-
V
-
K
-
G
V
E
L
D
L
P
A
L
M
A
H
K
D
K
V
V
Q
A
N
T
Q
G
-
V
E
F
L
F
K
--
K
N
G
-
I
A
R
H
Q
G
T
A
R
F
L
S
---------
E
R
--
K
V
------
L
V
-
E
-----------
E
-------
T
G
-
E
-------
E
-----
L
E
A
R
Y
I
L
I
A
T
G
S
A
P
L
--
I
P
P
W
A
Q
--
V
---
D
Y
E
-
R
-----
V
--
V
-
T
S
T
E
A
L
S
F
P
-
E
-
V
--
P
K
R
L
I
V
V
G
G
G
V
I
G
L
E
L
G
V
V
W
H
R
L
G
A
E
V
I
V
L
E
Y
M
D
R
I
L
P
T
M
D
L
E
V
S
R
A
A
E
R
V
F
K
K
Q
-
G
--
L
T
I
R
T
G
V
R
V
T
A
V
V
P
E
-
A
K
G
--
A
R
V
---
E
--
L
--
E
---
G
---
G
E
-
V
L
E
A
D
R
V
L
V
A
V
G
R
R
P
Y
T
E
G
L
S
L
E
N
A
G
L
S
T
D
E
R
G
R
I
P
V
D
E
H
L
R
T
R
V
P
H
I
Y
A
I
G
D
---
V
V
R
-
G
-
P
-
M
L
A
H
K
A
S
E
E
G
I
A
A
V
E
-
H
M
V
R
G
F
--
G
H
-----
V
D
Y
Q
A
----
I
P
S
V
V
Y
T
H
P
E
I
A
A
V
G
Y
T
E
E
E
L
K
A
Q
G
-
I
-
P
--
Y
K
V
G
-
K
F
P
Y
S
A
S
G
R
A
R
A
M
G
E
T
E
G
F
I
K
V
L
A
H
A
K
T
D
R
I
L
G
V
H
G
I
G
A
R
-
V
G
D
V
L
A
E
A
A
L
A
L
F
F
K
A
S
A
E
D
L
G
R
A
P
H
A
H
P
---
S
L
S
E
--
I
L
K
E
A
A
L
A
A
W
E
R
P
I
H
L
--
13
PsiBlast_PDB
78.82
41%
-112
- C2 -
3LAD
2
DLDH_AZOVI
A:
[5-471]
-----------
D
V
I
V
I
G
A
G
P
G
G
Y
V
A
A
I
K
S
A
Q
L
G
L
K
T
A
L
I
E
K
YKGKEGK
T
------
A
-
L
G
G
T
C
L
N
V
G
C
I
P
S
K
A
L
L
-
D
S
S
Y
-
K
F
H
E
A
H
-
E
-
S
-
F
---
K
---
L
H
G
I
S
-
T
-
G
-
E
V
A
I
D
V
P
T
M
I
A
R
K
D
Q
I
V
R
N
L
T
G
G
-
V
A
S
L
I
K
--
A
N
G
-
V
T
L
F
E
G
H
G
K
L
L
A
---------
G
K
K
V
E
V
------
T
A
A
D
-----------
G
-------
S
S
-
Q
-------
V
-----
L
D
T
E
N
V
I
L
A
S
G
S
K
P
V
--
E
I
P
P
A
P
--
V
---
D
-
Q
-
D
-----
V
--
I
V
D
S
T
G
A
L
D
F
Q
-
N
-
V
--
P
G
K
L
G
V
I
G
A
G
V
I
G
L
E
L
G
S
V
W
A
R
L
G
A
E
V
T
V
L
E
A
M
D
K
F
L
P
A
V
D
E
Q
V
A
K
E
A
Q
K
I
L
T
K
Q
-
G
--
L
K
I
L
L
G
A
R
V
T
G
T
E
V
K
-
N
K
Q
--
V
T
V
K
F
-
V
--
D
--
A
---
E
---
G
E
K
S
Q
A
F
D
K
L
I
V
A
V
G
R
R
P
V
T
T
D
L
L
A
A
D
S
G
V
T
L
D
E
R
G
F
I
Y
V
D
D
Y
C
A
T
S
V
P
G
V
Y
A
I
G
D
---
V
V
R
-
G
-
A
-
M
L
A
H
K
A
S
E
E
G
V
V
V
A
E
-
R
I
A
G
H
K
--
A
Q
-----
M
N
Y
D
L
----
I
P
A
V
I
Y
T
H
P
E
I
A
G
V
G
K
T
E
Q
A
L
K
A
E
G
-
V
-
A
--
I
N
V
G
-
V
F
P
F
A
A
S
G
R
A
M
A
A
N
D
T
A
G
F
V
K
V
I
A
D
A
K
T
D
R
V
L
G
V
H
V
I
G
P
S
-
A
A
E
L
V
Q
Q
G
A
I
A
M
E
F
G
T
S
A
E
D
L
G
M
M
V
F
A
H
P
---
A
L
S
E
--
A
L
H
E
A
A
L
A
V
S
G
H
A
I
H
V
--
7
PsiBlast_PDB
78.58
42%
-105
- C2 -
1LPF
2
DLDH_PSEFL
A:
[5-471]
-----------
D
V
V
V
I
G
A
G
P
G
G
Y
V
A
A
I
R
A
A
Q
L
G
L
K
T
A
C
I
E
K
YIGKEGK
V
------
A
-
L
G
G
T
C
L
N
V
G
C
I
P
S
K
A
L
L
-
D
S
S
Y
-
K
Y
H
E
A
K
-
E
-
A
-
F
---
K
---
V
H
G
I
E
-
A
-
K
-
G
V
T
I
D
V
P
A
M
V
A
R
K
A
N
I
V
K
N
L
T
G
G
-
I
A
T
L
F
K
--
A
N
G
-
V
T
S
F
E
G
H
G
K
L
L
A
---------
N
K
Q
V
E
V
------
T
G
L
D
-----------
G
-------
K
T
-
Q
-------
V
-----
L
E
A
E
N
V
I
I
A
S
G
S
R
P
V
--
E
I
P
P
A
P
--
L
---
S
-
D
-
D
-----
I
--
I
V
D
S
T
G
A
L
E
F
Q
-
A
-
V
--
P
K
K
L
G
V
I
G
A
G
V
I
G
L
E
L
G
S
V
W
A
R
L
G
A
E
V
T
V
L
E
A
L
D
K
F
L
P
A
A
D
E
Q
I
A
K
E
A
L
K
V
L
T
K
Q
-
G
--
L
N
I
R
L
G
A
R
V
T
A
S
E
V
K
-
K
K
Q
--
V
T
V
T
F
T
D
--
A
--
N
---
G
---
E
Q
K
E
T
-
F
D
K
L
I
V
A
V
G
R
R
P
V
T
T
D
L
L
A
A
D
S
G
V
T
L
D
E
R
G
F
I
Y
V
D
D
H
C
K
T
S
V
P
G
V
F
A
I
G
D
---
V
V
R
-
G
-
A
-
M
L
A
H
K
A
S
E
E
G
V
M
V
A
E
-
R
I
A
G
H
K
--
A
Q
-----
M
N
Y
D
L
----
I
P
S
V
I
Y
T
H
P
E
I
A
W
V
G
K
T
E
Q
T
L
K
A
E
G
-
V
-
E
--
V
N
V
G
-
T
F
P
F
A
A
S
G
R
A
M
A
A
N
D
T
T
G
L
V
K
V
I
A
D
A
K
T
D
R
V
L
G
V
H
V
I
G
P
S
-
A
A
E
L
V
Q
Q
G
A
I
G
M
E
F
G
T
S
A
E
D
L
G
M
M
V
F
S
H
P
---
T
L
S
E
--
A
L
H
E
A
A
L
A
V
N
G
H
A
I
H
I
--
77
PsiBlast_CBE
78.57
43%
-110
- C2 -
2YQU
6
?
B:
[3-455]
-----------
D
L
L
V
I
G
A
G
P
G
G
Y
V
A
A
I
R
A
A
Q
L
G
M
K
V
G
V
V
E
K
E------
K
------
A
-
L
G
G
T
C
L
R
V
G
C
I
P
S
K
A
L
L
-
E
T
T
E
-
R
I
Y
E
A
K
---
K
-
G
---
L
---
L
-
G
A
K
-
V
-
K
-
G
V
E
L
D
L
P
A
L
M
A
H
K
D
K
V
V
Q
A
N
T
Q
G
-
V
E
F
L
F
K
--
K
N
G
-
I
A
R
H
Q
G
T
A
R
F
L
S
---------
E
R
--
K
V
------
L
V
-
E
-----------
E
-------
T
G
-
E
-------
E
-----
L
E
A
R
Y
I
L
I
A
T
G
S
A
P
L
--
I
P
P
W
A
Q
--
V
---
D
Y
E
-
R
-----
V
--
V
-
T
S
T
E
A
L
S
F
P
-
E
-
V
--
P
K
R
L
I
V
V
G
G
G
V
I
G
L
E
L
G
V
V
W
H
R
L
G
A
E
V
I
V
L
E
Y
M
D
R
I
L
P
T
M
D
L
E
V
S
R
A
A
E
R
V
F
K
K
Q
-
G
--
L
T
I
R
T
G
V
R
V
T
A
V
V
P
E
-
A
K
G
--
A
R
V
---
E
--
L
--
E
---
G
---
G
E
-
V
L
E
A
D
R
V
L
V
A
V
G
R
R
P
Y
T
E
G
L
S
L
E
N
A
G
L
S
T
D
E
R
G
R
I
P
V
D
E
H
L
R
T
R
V
P
H
I
Y
A
I
G
D
---
V
V
R
-
G
-
P
-
M
L
A
H
K
A
S
E
E
G
I
A
A
V
E
-
H
M
V
R
G
F
--
G
H
-----
V
D
Y
Q
A
----
I
P
S
V
V
Y
T
H
P
E
I
A
A
V
G
Y
T
E
E
E
L
K
A
Q
G
-
I
-
P
--
Y
K
V
G
-
K
F
P
Y
S
A
S
G
R
A
R
A
M
G
E
T
E
G
F
I
K
V
L
A
H
A
K
T
D
R
I
L
G
V
H
G
I
G
A
R
-
V
G
D
V
L
A
E
A
A
L
A
L
F
F
K
A
S
A
E
D
L
G
R
A
P
H
A
H
P
---
S
L
S
E
--
I
L
K
E
A
A
L
A
A
W
E
R
P
I
H
L
--
2
PsiBlast_PDB
78.55
47%
-110
- C2 -
4JDR
9
DLDH_ECOLI
A:
[5-462]
-------
I
K
T
-
Q
V
V
V
L
G
A
G
P
A
G
Y
S
A
A
F
R
C
A
D
L
G
L
E
T
V
I
V
E
R
-------
Y
N-----
T
-
L
G
G
V
C
L
N
V
G
C
I
P
S
K
A
L
L
-
H
V
A
K
-
V
I
E
E
A
K
-
A
-
L
-
A
---
E
---
H
-
G
I
V
-
F
-
G
-
E
P
K
T
D
I
D
K
I
R
T
W
K
E
K
V
I
N
Q
L
T
G
G
-
L
A
G
M
A
K
--
G
R
K
-
V
K
V
V
N
G
L
G
K
F
T
G
---------
A
N
T
L
E
V
------
E
G
-
E
-----------
N
-------
G
K
-
T
-------
V
-----
I
N
F
D
N
A
I
I
A
A
G
S
R
P
I
--
Q
L
P
F
I
P
--
H
---
E
-
D
P
R
-----
I
--
W
-
D
S
T
D
A
L
E
L
K
-
E
-
V
--
P
E
R
L
L
V
M
G
G
G
I
I
G
L
E
M
G
T
V
Y
H
A
L
G
S
Q
I
D
V
V
E
M
F
D
Q
V
I
P
A
A
D
K
D
I
V
K
V
F
T
K
R
I
S
K
K
-
F
-
N
L
M
L
E
T
K
V
T
A
--
V
E
A
K
-
E
D
G
--
I
Y
V
T
M
-
E
--
G
--
K
KAP
A
---
E
P
Q
R
Y
D
A
--
V
L
V
A
I
G
R
V
P
N
G
K
N
L
D
A
G
K
A
G
V
E
V
D
D
R
G
F
I
R
V
D
K
Q
L
R
T
N
V
P
H
I
F
A
I
G
D
---
I
V
G
-
Q
-
P
-
M
L
A
H
K
G
V
H
E
G
H
V
A
A
E
-
V
I
A
G
K
K
--
H
Y
-----
F
D
P
K
V
----
I
P
S
I
A
Y
T
E
P
E
V
A
W
V
G
L
T
E
K
E
A
K
E
K
G
-
I
-
S
--
Y
E
T
A
-
T
F
P
W
A
A
S
G
R
A
I
A
S
D
C
A
D
G
M
T
K
L
I
F
D
K
E
S
H
R
V
I
G
G
A
I
V
G
T
N
-
G
G
E
L
L
G
E
I
G
L
A
I
E
M
G
C
D
A
E
D
I
A
L
T
I
H
A
H
P
---
T
L
H
E
--
S
V
G
L
A
A
E
V
F
E
G
S
------
125
HHSearch
78.52
46%
-110
- C2 -
4JQ9
14
?
A:
[2-465]
----
S
T
E
I
K
T
-
Q
V
V
V
L
G
A
G
P
A
G
Y
S
A
A
F
R
C
A
D
L
G
L
E
T
V
I
V
E
R
Y------
N
------
T
-
L
G
G
V
C
L
N
V
G
C
I
P
S
K
A
L
L
-
H
V
A
K
-
V
I
E
E
A
K
-
A
-
L
-
A
---
E
---
H
-
G
I
V
-
F
-
G
-
E
P
K
T
D
I
D
K
I
R
T
W
K
E
K
V
I
N
Q
L
T
G
G
-
L
A
G
M
A
K
--
G
R
K
-
V
K
V
V
N
G
L
G
K
F
T
G
---------
A
N
T
L
E
V
------
E
G
-
E
-----------
N
-------
G
K
-
T
-------
V
-----
I
N
F
D
N
A
I
I
A
A
G
S
R
P
I
--
Q
L
P
-
F
I
--
P
HE-
D
-
P
-
R
-----
I
--
W
-
D
S
T
D
A
L
E
L
K
-
E
-
V
--
P
E
R
L
L
V
M
G
G
G
I
I
G
L
E
M
G
T
V
Y
H
A
L
G
S
Q
I
D
V
V
E
M
F
D
Q
V
I
P
A
A
D
K
D
I
V
K
V
F
T
K
R
I
S
---
K
-
K
F
N
L
M
L
E
T
K
V
T
A
V
E
A
K
-
E
D
G
--
I
Y
V
T
M
-
E
--
G
--
K
K--
A
---
P
A
E
P
Q
R
Y
D
A
V
L
V
A
I
G
R
V
P
N
G
K
N
L
D
A
G
K
A
G
V
E
V
D
D
R
G
F
I
R
V
D
K
Q
L
R
T
N
V
P
H
I
F
A
I
G
D
---
I
V
G
-
Q
-
P
-
M
L
A
H
K
G
V
H
E
G
H
V
A
A
E
-
V
I
A
G
K
K
--
H
Y
-----
F
D
P
K
V
----
I
P
S
I
A
Y
T
E
P
E
V
A
W
V
G
L
T
E
K
E
A
K
E
K
G
-
I
-
S
--
Y
E
T
A
-
T
F
P
W
A
A
S
G
R
A
I
A
S
D
C
A
D
G
M
T
K
L
I
F
D
K
E
S
H
R
V
I
G
G
A
I
V
G
T
N
-
G
G
E
L
L
G
E
I
G
L
A
I
E
M
G
C
D
A
E
D
I
A
L
T
I
H
A
H
P
---
T
L
H
E
--
S
V
G
L
A
A
E
V
F
E
G
S
I
T
D
---
26
PsiBlast_CBE
78.34
47%
-110
- C2 -
4JQ9
10
?
B:
[5-462]
-------
I
K
T
-
Q
V
V
V
L
G
A
G
P
A
G
Y
S
A
A
F
R
C
A
D
L
G
L
E
T
V
I
V
E
R
-------
Y
N-----
T
-
L
G
G
V
C
L
N
V
G
C
I
P
S
K
A
L
L
-
H
V
A
K
-
V
I
E
E
A
K
-
A
-
L
-
A
---
E
---
H
-
G
I
V
-
F
-
G
-
E
P
K
T
D
I
D
K
I
R
T
W
K
E
K
V
I
N
Q
L
T
G
G
-
L
A
G
M
A
K
--
G
R
K
-
V
K
V
V
N
G
L
G
K
F
T
G
---------
A
N
T
L
E
V
------
E
G
-
E
-----------
N
-------
G
K
-
T
-------
V
-----
I
N
F
D
N
A
I
I
A
A
G
S
R
P
I
--
Q
L
P
F
I
P
--
H
---
E
-
D
P
R
-----
I
--
W
-
D
S
T
D
A
L
E
L
K
-
E
-
V
--
P
E
R
L
L
V
M
G
G
G
I
I
G
L
E
M
G
T
V
Y
H
A
L
G
S
Q
I
D
V
V
E
M
F
D
Q
V
I
P
A
A
D
K
D
I
V
K
V
F
T
K
R
I
S
K
K
-
F
-
N
L
M
L
E
T
K
V
T
A
--
V
E
A
K
-
E
D
G
--
I
Y
V
T
M
-
E
--
G
--
K
KAP
A
---
E
P
Q
R
Y
D
A
--
V
L
V
A
I
G
R
V
P
N
G
K
N
L
D
A
G
K
A
G
V
E
V
D
D
R
G
F
I
R
V
D
K
Q
L
R
T
N
V
P
H
I
F
A
I
G
D
---
I
V
G
-
Q
-
P
-
M
L
A
H
K
G
V
H
E
G
H
V
A
A
E
-
V
I
A
G
K
K
--
H
Y
-----
F
D
P
K
V
----
I
P
S
I
A
Y
T
E
P
E
V
A
W
V
G
L
T
E
K
E
A
K
E
K
G
-
I
-
S
--
Y
E
T
A
-
T
F
P
W
A
A
S
G
R
A
I
A
S
D
C
A
D
G
M
T
K
L
I
F
D
K
E
S
H
R
V
I
G
G
A
I
V
G
T
N
-
G
G
E
L
L
G
E
I
G
L
A
I
E
M
G
C
D
A
E
D
I
A
L
T
I
H
A
H
P
---
T
L
H
E
--
S
V
G
L
A
A
E
V
F
E
G
S
------
129
HHSearch
78.18
42%
-112
- C2 -
3LAD
2
DLDH_AZOVI
A:
[2-471]
-------
Q
K
F
-
D
V
I
V
I
G
A
G
P
G
G
Y
V
A
A
I
K
S
A
Q
L
G
L
K
T
A
L
I
E
K
Y------
K
GKEGKT
A
-
L
G
G
T
C
L
N
V
G
C
I
P
S
K
A
L
L
-
D
S
S
Y
-
K
F
H
E
A
H
E
S
-
F
-
K
---
L
---
H
-
G
I
S
-
T
-
G
-
E
V
A
I
D
V
P
T
M
I
A
R
K
D
Q
I
V
R
N
L
T
G
G
-
V
A
S
L
I
K
--
A
N
G
-
V
T
L
F
E
G
H
G
K
L
L
A
---------
G
K
K
V
E
V
------
T
A
-
A
-----------
D
G------
S
S
-
Q
-------
V
-----
L
D
T
E
N
V
I
L
A
S
G
S
K
P
V
--
E
I
P
-
P
A
--
P
VD-
Q
-
D
-
V
-----
I
--
V
-
D
S
T
G
A
L
D
F
Q
-
N
-
V
--
P
G
K
L
G
V
I
G
A
G
V
I
G
L
E
L
G
S
V
W
A
R
L
G
A
E
V
T
V
L
E
A
M
D
K
F
L
P
A
V
D
E
Q
V
A
K
E
A
Q
K
I
L
T
K
--
Q
-
G
L
K
I
L
L
G
A
R
V
T
G
T
E
V
K
-
N
K
Q
--
V
T
V
K
F
-
V
--
D
--
A
---
E
---
G
E
K
S
Q
A
F
D
K
L
I
V
A
V
G
R
R
P
V
T
T
D
L
L
A
A
D
S
G
V
T
L
D
E
R
G
F
I
Y
V
D
D
Y
C
A
T
S
V
P
G
V
Y
A
I
G
D
---
V
V
R
-
G
-
A
-
M
L
A
H
K
A
S
E
E
G
V
V
V
A
E
-
R
I
A
G
H
K
--
A
Q
-----
M
N
Y
D
L
----
I
P
A
V
I
Y
T
H
P
E
I
A
G
V
G
K
T
E
Q
A
L
K
A
E
G
-
V
-
A
--
I
N
V
G
-
V
F
P
F
A
A
S
G
R
A
M
A
A
N
D
T
A
G
F
V
K
V
I
A
D
A
K
T
D
R
V
L
G
V
H
V
I
G
P
S
-
A
A
E
L
V
Q
Q
G
A
I
A
M
E
F
G
T
S
A
E
D
L
G
M
M
V
F
A
H
P
---
A
L
S
E
--
A
L
H
E
A
A
L
A
V
S
G
H
A
I
H
V
--
25
PsiBlast_CBE
78.18
47%
-108
- C2 -
4JQ9
2
?
C:
[5-462]
-------
I
K
T
-
Q
V
V
V
L
G
A
G
P
A
G
Y
S
A
A
F
R
C
A
D
L
G
L
E
T
V
I
V
E
R
-------
Y
N-----
T
-
L
G
G
V
C
L
N
V
G
C
I
P
S
K
A
L
L
-
H
V
A
K
-
V
I
E
E
A
K
-
A
-
L
-
A
---
E
---
H
-
G
I
V
-
F
-
G
-
E
P
K
T
D
I
D
K
I
R
T
W
K
E
K
V
I
N
Q
L
T
G
G
-
L
A
G
M
A
K
--
G
R
K
-
V
K
V
V
N
G
L
G
K
F
T
G
---------
A
N
T
L
E
V
------
E
G
-
E
-----------
N
-------
G
K
-
T
-------
V
-----
I
N
F
D
N
A
I
I
A
A
G
S
R
P
I
--
Q
L
P
F
I
P
--
H
---
E
-
D
P
R
-----
I
--
W
-
D
S
T
D
A
L
E
L
K
-
E
-
V
--
P
E
R
L
L
V
M
G
G
G
I
I
G
L
E
M
G
T
V
Y
H
A
L
G
S
Q
I
D
V
V
E
M
F
D
Q
V
I
P
A
A
D
K
D
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K
V
F
T
K
R
I
S
K
K
-
F
-
N
L
M
L
E
T
K
V
T
A
--
V
E
A
K
-
E
D
G
--
I
Y
V
T
M
-
E
--
G
--
K
KAP
A
---
E
P
Q
R
Y
D
A
--
V
L
V
A
I
G
R
V
P
N
G
K
N
L
D
A
G
K
A
G
V
E
V
D
D
R
G
F
I
R
V
D
K
Q
L
R
T
N
V
P
H
I
F
A
I
G
D
---
I
V
G
-
Q
-
P
-
M
L
A
H
K
G
V
H
E
G
H
V
A
A
E
-
V
I
A
G
K
K
--
H
Y
-----
F
D
P
K
V
----
I
P
S
I
A
Y
T
E
P
E
V
A
W
V
G
L
T
E
K
E
A
K
E
K
G
-
I
-
S
--
Y
E
T
A
-
T
F
P
W
A
A
S
G
R
A
I
A
S
D
C
A
D
G
M
T
K
L
I
F
D
K
E
S
H
R
V
I
G
G
A
I
V
G
T
N
-
G
G
E
L
L
G
E
I
G
L
A
I
E
M
G
C
D
A
E
D
I
A
L
T
I
H
A
H
P
---
T
L
H
E
--
S
V
G
L
A
A
E
V
F
E
G
S
------
39
PsiBlast_CBE
78.14
42%
-106
- C2 -
1LPF
2
DLDH_PSEFL
B:
[5-471]
-----------
D
V
V
V
I
G
A
G
P
G
G
Y
V
A
A
I
R
A
A
Q
L
G
L
K
T
A
C
I
E
K
YIGKEGK
V
------
A
-
L
G
G
T
C
L
N
V
G
C
I
P
S
K
A
L
L
-
D
S
S
Y
-
K
Y
H
E
A
K
-
E
-
A
-
F
---
K
---
V
H
G
I
E
-
A
-
K
-
G
V
T
I
D
V
P
A
M
V
A
R
K
A
N
I
V
K
N
L
T
G
G
-
I
A
T
L
F
K
--
A
N
G
-
V
T
S
F
E
G
H
G
K
L
L
A
---------
N
K
Q
V
E
V
------
T
G
L
D
-----------
G
-------
K
T
-
Q
-------
V
-----
L
E
A
E
N
V
I
I
A
S
G
S
R
P
V
--
E
I
P
P
A
P
--
L
---
S
-
D
-
D
-----
I
--
I
V
D
S
T
G
A
L
E
F
Q
-
A
-
V
--
P
K
K
L
G
V
I
G
A
G
V
I
G
L
E
L
G
S
V
W
A
R
L
G
A
E
V
T
V
L
E
A
L
D
K
F
L
P
A
A
D
E
Q
I
A
K
E
A
L
K
V
L
T
K
Q
-
G
--
L
N
I
R
L
G
A
R
V
T
A
S
E
V
K
-
K
K
Q
--
V
T
V
T
F
T
D
--
A
--
N
---
G
---
E
Q
K
E
T
-
F
D
K
L
I
V
A
V
G
R
R
P
V
T
T
D
L
L
A
A
D
S
G
V
T
L
D
E
R
G
F
I
Y
V
D
D
H
C
K
T
S
V
P
G
V
F
A
I
G
D
---
V
V
R
-
G
-
A
-
M
L
A
H
K
A
S
E
E
G
V
M
V
A
E
-
R
I
A
G
H
K
--
A
Q
-----
M
N
Y
D
L
----
I
P
S
V
I
Y
T
H
P
E
I
A
W
V
G
K
T
E
Q
T
L
K
A
E
G
-
V
-
E
--
V
N
V
G
-
T
F
P
F
A
A
S
G
R
A
M
A
A
N
D
T
T
G
L
V
K
V
I
A
D
A
K
T
D
R
V
L
G
V
H
V
I
G
P
S
-
A
A
E
L
V
Q
Q
G
A
I
G
M
E
F
G
T
S
A
E
D
L
G
M
M
V
F
S
H
P
---
T
L
S
E
--
A
L
H
E
A
A
L
A
V
N
G
H
A
I
H
I
--
141
HHSearch
78.00
43%
-112
- C2 -
2YQU
4
?
A:
[1-452]
--------
M
Y
-
D
L
L
V
I
G
A
G
P
G
G
Y
V
A
A
I
R
A
A
Q
L
G
M
K
V
G
V
V
E
K
E------
K
------
A
-
L
G
G
T
C
L
R
V
G
C
I
P
S
K
A
L
L
-
E
T
T
E
-
R
I
Y
E
A
K
-
K
---
G
---
L
---
L
-
G
A
K
-
V
-
K
-
G
V
E
L
D
L
P
A
L
M
A
H
K
D
K
V
V
Q
A
N
T
Q
G
-
V
E
F
L
F
K
--
K
N
G
-
I
A
R
H
Q
G
T
A
R
F
L
S
---------
E
R
K
V
L
V
------
E
E
---------------------
T
G
-
E
-------
E
-----
L
E
A
R
Y
I
L
I
A
T
G
S
A
P
L
--
I
P
P
-
W
A
--
Q
VD-
Y
-
E
-
R
-----
V
--
V
-
T
S
T
E
A
L
S
F
P
-
E
-
V
--
P
K
R
L
I
V
V
G
G
G
V
I
G
L
E
L
G
V
V
W
H
R
L
G
A
E
V
I
V
L
E
Y
M
D
R
I
L
P
T
M
D
L
E
V
S
R
A
A
E
R
V
F
K
K
--
Q
-
G
L
T
I
R
T
G
V
R
V
T
A
V
V
P
E
-
A
K
G
--
A
R
V
E
L
-
E
-------------
G
G
E
V
L
E
A
D
R
V
L
V
A
V
G
R
R
P
Y
T
E
G
L
S
L
E
N
A
G
L
S
T
D
E
R
G
R
I
P
V
D
E
H
L
R
T
R
V
P
H
I
Y
A
I
G
D
---
V
V
R
-
G
-
P
-
M
L
A
H
K
A
S
E
E
G
I
A
A
V
E
-
H
M
V
R
G
F
--
G
H
-----
V
D
Y
Q
A
----
I
P
S
V
V
Y
T
H
P
E
I
A
A
V
G
Y
T
E
E
E
L
K
A
Q
G
-
I
-
P
--
Y
K
V
G
-
K
F
P
Y
S
A
S
G
R
A
R
A
M
G
E
T
E
G
F
I
K
V
L
A
H
A
K
T
D
R
I
L
G
V
H
G
I
G
A
R
-
V
G
D
V
L
A
E
A
A
L
A
L
F
F
K
A
S
A
E
D
L
G
R
A
P
H
A
H
P
---
S
L
S
E
--
I
L
K
E
A
A
L
A
A
W
E
R
P
-----
19
PsiBlast_PDB
77.85
43%
-107
- C2 -
3URH
3
?
A:
[27-486]
-----------
D
L
I
V
I
G
S
G
P
G
G
Y
V
C
A
I
K
A
A
Q
L
G
M
K
V
A
V
V
E
K
R------
S
------
T
-
Y
G
G
T
C
L
N
V
G
C
I
P
S
K
A
L
L
-
H
A
S
E
-
M
F
H
Q
A
Q
-
H
-
G
L
E
---
A
---
L
-
G
V
E
-
V
-
A
-
N
P
K
L
N
L
Q
K
M
M
A
H
K
D
A
T
V
K
S
N
V
D
G
-
V
S
F
L
F
K
--
K
N
K
-
I
D
G
F
Q
G
T
G
K
V
L
G
---------
Q
G
K
V
S
V
------
T
N
-
E
-----------
K
-------
G
E
E
Q
-------
V
-----
L
E
A
K
N
V
V
I
A
T
G
S
D
V
A
--
G
I
P
G
V
E
V
A
F
---
D
-
E
-
K
T----
I
--
V
-
S
S
T
G
A
L
A
L
E
-
K
-
V
--
P
A
S
M
I
V
V
G
G
G
V
I
G
L
E
L
G
S
V
W
A
R
L
G
A
K
V
T
V
V
E
F
L
D
T
I
L
G
G
M
D
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M
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-
G
--
I
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-
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--
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P-
V
--
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---
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G
--
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T
L
D
A
E
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V
L
I
A
T
G
R
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P
S
T
D
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L
G
L
A
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A
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V
L
D
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G
R
V
E
I
D
R
H
F
Q
T
S
I
A
G
V
Y
A
I
G
D
---
V
V
R
-
G
-
P
-
M
L
A
H
K
A
E
D
E
G
V
A
V
A
E
-
I
I
A
G
Q
A
--
G
H
-----
V
N
Y
D
V
----
I
P
G
V
V
Y
T
Q
P
E
V
A
S
V
G
K
T
E
E
E
L
K
A
A
G
-
V
-
A
--
Y
K
I
G
-
K
F
P
F
T
A
N
G
R
A
R
A
M
L
Q
T
D
G
F
V
K
I
L
A
D
K
E
T
D
R
V
L
G
G
H
I
I
G
F
G
-
A
G
E
M
I
H
E
I
A
V
L
M
E
F
G
G
S
S
E
D
L
G
R
T
C
H
A
H
P
---
T
M
S
E
--
A
V
K
E
A
A
L
S
T
F
F
-------
124
HHSearch
77.74
43%
-107
* C2 *
3URH
3
?
A:
[26-486]
---------
Y
-
D
L
I
V
I
G
S
G
P
G
G
Y
V
C
A
I
K
A
A
Q
L
G
M
K
V
A
V
V
E
K
R------
S
------
T
-
Y
G
G
T
C
L
N
V
G
C
I
P
S
K
A
L
L
-
H
A
S
E
-
M
F
H
Q
A
Q
-
H
G
L
-
E
---
A
---
L
-
G
V
E
-
V
-
A
-
N
P
K
L
N
L
Q
K
M
M
A
H
K
D
A
T
V
K
S
N
V
D
G
-
V
S
F
L
F
K
--
K
N
K
-
I
D
G
F
Q
G
T
G
K
V
L
G
---------
Q
G
K
V
S
V
------
T
N
-
E
-----------
K
G------
E
E
-
Q
-------
V
-----
L
E
A
K
N
V
V
I
A
T
G
S
D
V
A
--
G
I
P
G
V
E
--
V
A
F
D
E
-
K
-
T
-----
I
--
V
-
S
S
T
G
A
L
A
L
E
-
K
-
V
--
P
A
S
M
I
V
V
G
G
G
V
I
G
L
E
L
G
S
V
W
A
R
L
G
A
K
V
T
V
V
E
F
L
D
T
I
L
G
G
M
D
G
E
V
A
K
Q
L
Q
R
M
L
T
K
--
Q
-
G
I
D
F
K
L
G
A
K
V
T
G
A
V
K
S
-
G
D
G
--
A
K
V
T
F
-
E
PV
K
--
G
---
G
---
E
A
T
T
L
D
A
E
V
V
L
I
A
T
G
R
K
P
S
T
D
G
L
G
L
A
K
A
G
V
V
L
D
S
R
G
R
V
E
I
D
R
H
F
Q
T
S
I
A
G
V
Y
A
I
G
D
---
V
V
R
-
G
-
P
-
M
L
A
H
K
A
E
D
E
G
V
A
V
A
E
-
I
I
A
G
Q
A
--
G
H
-----
V
N
Y
D
V
----
I
P
G
V
V
Y
T
Q
P
E
V
A
S
V
G
K
T
E
E
E
L
K
A
A
G
-
V
-
A
--
Y
K
I
G
-
K
F
P
F
T
A
N
G
R
A
R
A
M
L
Q
T
D
G
F
V
K
I
L
A
D
K
E
T
D
R
V
L
G
G
H
I
I
G
F
G
-
A
G
E
M
I
H
E
I
A
V
L
M
E
F
G
G
S
S
E
D
L
G
R
T
C
H
A
H
P
---
T
M
S
E
--
A
V
K
E
A
A
L
S
T
F
F
-------
27
PsiBlast_CBE
77.52
47%
-108
- C2 -
4JDR
5
DLDH_ECOLI
B:
[5-462]
-------
I
K
T
-
Q
V
V
V
L
G
A
G
P
A
G
Y
S
A
A
F
R
C
A
D
L
G
L
E
T
V
I
V
E
R
-------
Y
N-----
T
-
L
G
G
V
C
L
N
V
G
C
I
P
S
K
A
L
L
-
H
V
A
K
-
V
I
E
E
A
K
-
A
-
L
-
A
---
E
---
H
-
G
I
V
-
F
-
G
-
E
P
K
T
D
I
D
K
I
R
T
W
K
E
K
V
I
N
Q
L
T
G
G
-
L
A
G
M
A
K
--
G
R
K
-
V
K
V
V
N
G
L
G
K
F
T
G
---------
A
N
T
L
E
V
------
E
G
-
E
-----------
N
-------
G
K
-
T
-------
V
-----
I
N
F
D
N
A
I
I
A
A
G
S
R
P
I
--
Q
L
P
F
I
P
--
H
---
E
-
D
P
R
-----
I
--
W
-
D
S
T
D
A
L
E
L
K
-
E
-
V
--
P
E
R
L
L
V
M
G
G
G
I
I
G
L
E
M
G
T
V
Y
H
A
L
G
S
Q
I
D
V
V
E
M
F
D
Q
V
I
P
A
A
D
K
D
I
V
K
V
F
T
K
R
I
S
K
K
-
F
-
N
L
M
L
E
T
K
V
T
A
--
V
E
A
K
-
E
D
G
--
I
Y
V
T
M
-
E
--
G
--
K
KAP
A
---
E
P
Q
R
Y
D
A
--
V
L
V
A
I
G
R
V
P
N
G
K
N
L
D
A
G
K
A
G
V
E
V
D
D
R
G
F
I
R
V
D
K
Q
L
R
T
N
V
P
H
I
F
A
I
G
D
---
I
V
G
-
Q
-
P
-
M
L
A
H
K
G
V
H
E
G
H
V
A
A
E
-
V
I
A
G
K
K
--
H
Y
-----
F
D
P
K
V
----
I
P
S
I
A
Y
T
E
P
E
V
A
W
V
G
L
T
E
K
E
A
K
E
K
G
-
I
-
S
--
Y
E
T
A
-
T
F
P
W
A
A
S
G
R
A
I
A
S
D
C
A
D
G
M
T
K
L
I
F
D
K
E
S
H
R
V
I
G
G
A
I
V
G
T
N
-
G
G
E
L
L
G
E
I
G
L
A
I
E
M
G
C
D
A
E
D
I
A
L
T
I
H
A
H
P
---
T
L
H
E
--
S
V
G
L
A
A
E
V
F
E
G
S
------
38
PsiBlast_CBE
77.47
45%
-100
- C2 -
2EQ6
2
?
B:
[4-462]
-------
M
K
T
Y
D
L
I
V
I
G
T
G
P
G
G
Y
H
A
A
I
R
A
A
Q
L
G
L
K
V
L
A
V
E
A
-------
G
------
E
-
V
G
G
V
C
L
N
V
G
C
I
P
T
K
A
L
L
-
H
A
A
E
-
T
L
H
H
L
K
-
V
-
A
-
E
---
G
---
F
-
G
L
K
-
A
-
K
-
P
-
E
L
D
L
K
K
L
G
G
W
R
D
Q
V
V
K
K
L
T
G
G
-
V
G
T
L
L
K
--
G
N
G
-
V
E
L
L
R
G
F
A
R
L
V
G
---------
P
K
E
V
E
V
------
G
G
-
E
-----------
R
------------------------
Y
G
A
K
S
L
I
L
A
T
G
S
E
P
L
--
E
L
K
G
F
P
--
F
---
G
-
E
-
D
-----
V
--
W
-
D
S
T
R
A
L
K
V
E
-
E
G
L
--
P
K
R
L
L
V
I
G
G
G
A
V
G
L
E
L
G
Q
V
Y
R
R
L
G
A
E
V
T
L
I
E
Y
M
P
E
I
L
P
Q
G
D
P
E
T
A
A
L
L
R
R
A
L
E
K
E
-
G
--
I
R
V
R
T
K
T
K
A
V
G
Y
E
K
K
-
K
D
G
--
L
H
V
R
L
-
E
PA
E
--
G
---
G
---
E
G
E
E
V
V
V
D
K
V
L
V
A
V
G
R
K
P
R
T
E
G
L
G
L
E
K
A
G
V
K
V
D
E
R
G
F
I
R
V
N
A
R
M
E
T
S
V
P
G
V
Y
A
I
G
D
---
A
A
R
-
P
-
P
-
L
L
A
H
K
A
M
R
E
G
L
I
A
A
E
-
N
A
A
G
K
D
--
S
A
-----
F
D
Y
Q
-----
V
P
S
V
V
Y
T
S
P
E
W
A
G
V
G
L
T
E
E
E
A
K
R
A
G
-
Y
-
K
--
V
K
V
G
-
K
F
P
L
A
A
S
G
R
A
L
T
L
G
G
A
E
G
M
V
K
V
V
G
D
E
E
T
D
L
L
L
G
V
F
I
V
G
P
Q
-
A
G
E
L
I
A
E
A
A
L
A
L
E
M
G
A
T
L
T
D
L
A
L
T
V
H
P
H
P
---
T
L
S
E
--
S
L
M
E
A
A
E
A
F
H
K
Q
A
I
H
I
L
-
73
PsiBlast_CBE
77.46
41%
-108
- C2 -
3LAD
2
DLDH_AZOVI
B:
[5-471]
-----------
D
V
I
V
I
G
A
G
P
G
G
Y
V
A
A
I
K
S
A
Q
L
G
L
K
T
A
L
I
E
K
YKGKEGK
T
------
A
-
L
G
G
T
C
L
N
V
G
C
I
P
S
K
A
L
L
-
D
S
S
Y
-
K
F
H
E
A
H
-
E
-
S
-
F
---
K
---
L
H
G
I
S
-
T
-
G
-
E
V
A
I
D
V
P
T
M
I
A
R
K
D
Q
I
V
R
N
L
T
G
G
-
V
A
S
L
I
K
--
A
N
G
-
V
T
L
F
E
G
H
G
K
L
L
A
---------
G
K
K
V
E
V
------
T
A
A
D
-----------
G
-------
S
S
-
Q
-------
V
-----
L
D
T
E
N
V
I
L
A
S
G
S
K
P
V
--
E
I
P
P
A
P
--
V
---
D
-
Q
-
D
-----
V
--
I
V
D
S
T
G
A
L
D
F
Q
-
N
-
V
--
P
G
K
L
G
V
I
G
A
G
V
I
G
L
E
L
G
S
V
W
A
R
L
G
A
E
V
T
V
L
E
A
M
D
K
F
L
P
A
V
D
E
Q
V
A
K
E
A
Q
K
I
L
T
K
Q
-
G
--
L
K
I
L
L
G
A
R
V
T
G
T
E
V
K
-
N
K
Q
--
V
T
V
K
F
-
V
--
D
--
A
---
E
---
G
E
K
S
Q
A
F
D
K
L
I
V
A
V
G
R
R
P
V
T
T
D
L
L
A
A
D
S
G
V
T
L
D
E
R
G
F
I
Y
V
D
D
Y
C
A
T
S
V
P
G
V
Y
A
I
G
D
---
V
V
R
-
G
-
A
-
M
L
A
H
K
A
S
E
E
G
V
V
V
A
E
-
R
I
A
G
H
K
--
A
Q
-----
M
N
Y
D
L
----
I
P
A
V
I
Y
T
H
P
E
I
A
G
V
G
K
T
E
Q
A
L
K
A
E
G
-
V
-
A
--
I
N
V
G
-
V
F
P
F
A
A
S
G
R
A
M
A
A
N
D
T
A
G
F
V
K
V
I
A
D
A
K
T
D
R
V
L
G
V
H
V
I
G
P
S
-
A
A
E
L
V
Q
Q
G
A
I
A
M
E
F
G
T
S
A
E
D
L
G
M
M
V
F
A
H
P
---
A
L
S
E
--
A
L
H
E
A
A
L
A
V
S
G
H
A
I
H
V
--
78
PsiBlast_CBE
77.18
43%
-108
- C2 -
2EQ7
3
?
B:
[3-452]
-----------
D
L
L
V
I
G
A
G
P
G
G
Y
V
A
A
I
R
A
A
Q
L
G
M
K
V
G
V
V
E
K
E------
K
------
A
-
L
G
G
T
C
L
R
V
G
C
I
P
S
K
A
L
L
-
E
T
T
E
-
R
I
Y
E
A
K
---
K
-
G
---
L
---
L
-
G
A
K
-
V
-
K
-
G
V
E
L
D
L
P
A
L
M
A
H
K
D
K
V
V
Q
A
N
T
Q
G
-
V
E
F
L
F
K
--
K
N
G
-
I
A
R
H
Q
G
T
A
R
F
L
S
---------
E
R
--
K
V
------
L
V
-
E
-----------
E
-------
T
G
-
E
-------
E
-----
L
E
A
R
Y
I
L
I
A
T
G
S
A
P
L
--
I
P
P
W
A
Q
--
V
---
D
Y
E
-
R
-----
V
--
V
-
T
S
T
E
A
L
S
F
P
-
E
-
V
--
P
K
R
L
I
V
V
G
G
G
V
I
G
L
E
L
G
V
V
W
H
R
L
G
A
E
V
I
V
L
E
Y
M
D
R
I
L
P
T
M
D
L
E
V
S
R
A
A
E
R
V
F
K
K
Q
-
G
--
L
T
I
R
T
G
V
R
V
T
A
V
V
P
E
-
A
K
G
--
A
R
V
---
E
--
L
--
E
---
G
---
G
E
-
V
L
E
A
D
R
V
L
V
A
V
G
R
R
P
Y
T
E
G
L
S
L
E
N
A
G
L
S
T
D
E
R
G
R
I
P
V
D
E
H
L
R
T
R
V
P
H
I
Y
A
I
G
D
---
V
V
R
-
G
-
P
-
M
L
A
H
K
A
S
E
E
G
I
A
A
V
E
-
H
M
V
R
G
F
--
G
H
-----
V
D
Y
Q
A
----
I
P
S
V
V
Y
T
H
P
E
I
A
A
V
G
Y
T
E
E
E
L
K
A
Q
G
-
I
-
P
--
Y
K
V
G
-
K
F
P
Y
S
A
S
G
R
A
R
A
M
G
E
T
E
G
F
I
K
V
L
A
H
A
K
T
D
R
I
L
G
V
H
G
I
G
A
R
-
V
G
D
V
L
A
E
A
A
L
A
L
F
F
K
A
S
A
E
D
L
G
R
A
P
H
A
H
P
---
S
L
S
E
--
I
L
K
E
A
A
L
A
A
W
E
R
P
-----
16
PsiBlast_PDB
77.17
43%
-108
- C2 -
2EQ7
3
?
A:
[3-452]
-----------
D
L
L
V
I
G
A
G
P
G
G
Y
V
A
A
I
R
A
A
Q
L
G
M
K
V
G
V
V
E
K
E------
K
------
A
-
L
G
G
T
C
L
R
V
G
C
I
P
S
K
A
L
L
-
E
T
T
E
-
R
I
Y
E
A
K
---
K
-
G
---
L
---
L
-
G
A
K
-
V
-
K
-
G
V
E
L
D
L
P
A
L
M
A
H
K
D
K
V
V
Q
A
N
T
Q
G
-
V
E
F
L
F
K
--
K
N
G
-
I
A
R
H
Q
G
T
A
R
F
L
S
---------
E
R
--
K
V
------
L
V
-
E
-----------
E
-------
T
G
-
E
-------
E
-----
L
E
A
R
Y
I
L
I
A
T
G
S
A
P
L
--
I
P
P
W
A
Q
--
V
---
D
Y
E
-
R
-----
V
--
V
-
T
S
T
E
A
L
S
F
P
-
E
-
V
--
P
K
R
L
I
V
V
G
G
G
V
I
G
L
E
L
G
V
V
W
H
R
L
G
A
E
V
I
V
L
E
Y
M
D
R
I
L
P
T
M
D
L
E
V
S
R
A
A
E
R
V
F
K
K
Q
-
G
--
L
T
I
R
T
G
V
R
V
T
A
V
V
P
E
-
A
K
G
--
A
R
V
---
E
--
L
--
E
---
G
---
G
E
-
V
L
E
A
D
R
V
L
V
A
V
G
R
R
P
Y
T
E
G
L
S
L
E
N
A
G
L
S
T
D
E
R
G
R
I
P
V
D
E
H
L
R
T
R
V
P
H
I
Y
A
I
G
D
---
V
V
R
-
G
-
P
-
M
L
A
H
K
A
S
E
E
G
I
A
A
V
E
-
H
M
V
R
G
F
--
G
H
-----
V
D
Y
Q
A
----
I
P
S
V
V
Y
T
H
P
E
I
A
A
V
G
Y
T
E
E
E
L
K
A
Q
G
-
I
-
P
--
Y
K
V
G
-
K
F
P
Y
S
A
S
G
R
A
R
A
M
G
E
T
E
G
F
I
K
V
L
A
H
A
K
T
D
R
I
L
G
V
H
G
I
G
A
R
-
V
G
D
V
L
A
E
A
A
L
A
L
F
F
K
A
S
A
E
D
L
G
R
A
P
H
A
H
P
---
S
L
S
E
--
I
L
K
E
A
A
L
A
A
W
E
R
P
-----
123
HHSearch
76.42
45%
-103
- C2 -
1OJT
1
?
A:
[1-476]
---
G
S
A
D
A
E
Y
-
D
V
V
V
L
G
G
G
P
G
G
Y
S
A
A
F
A
A
A
D
E
G
L
K
V
A
I
V
E
R
Y------
K
------
T
-
L
G
G
V
C
L
N
V
G
C
I
P
S
K
A
L
L
-
H
N
A
A
-
V
I
D
E
V
R
-
H
-
L
-
A
---
A
---
N
-
G
I
K
-
Y
-
P
-
E
P
E
L
D
I
D
M
L
R
A
Y
K
D
G
V
V
S
R
L
T
G
G
-
L
A
G
M
A
K
--
S
R
K
-
V
D
V
I
Q
G
D
G
Q
F
L
D
---------
P
H
H
L
E
V
------
S
L
-
T
A
G
DAYE
Q
A
A
P
T
G
-------
E
K
-
K
-------
I
-----
V
A
F
K
N
C
I
I
A
A
G
S
R
V
T
--
K
L
P
F
I
P
--
E
---
D
-
P
-
R
-----
I
--
I
-
D
S
S
G
A
L
A
L
K
-
E
-
V
--
P
G
K
L
L
I
I
G
G
G
I
I
G
L
E
M
G
T
V
Y
S
T
L
G
S
R
L
D
V
V
E
M
M
D
G
L
M
Q
G
A
D
R
D
L
V
K
V
W
Q
K
Q
N
E
Y
--
R
-
F
D
N
I
M
V
N
T
K
T
V
A
V
E
P
K
-
E
D
G
--
V
Y
V
T
F
-
E
--
G
A
-
N
---
A
---
P
K
E
P
Q
R
Y
D
A
V
L
V
A
A
G
R
A
P
N
G
K
L
I
S
A
E
K
A
G
V
A
V
T
D
R
G
F
I
E
V
D
K
Q
M
R
T
N
V
P
H
I
Y
A
I
G
D
---
I
V
G
-
Q
-
P
-
M
L
A
H
K
A
V
H
E
G
H
V
A
A
E
-
N
C
A
G
H
K
--
A
Y
-----
F
D
A
R
V
----
I
P
G
V
A
Y
T
S
P
E
V
A
W
V
G
E
T
E
L
S
A
K
A
S
A
-
R
-
K
--
I
T
K
A
-
N
F
P
W
A
A
S
G
R
A
I
A
N
G
C
D
K
P
F
T
K
L
I
F
D
A
E
T
G
R
I
I
G
G
G
I
V
G
P
N
-
G
G
D
M
I
G
E
V
C
L
A
I
E
M
G
C
D
A
A
D
I
G
K
T
I
H
P
H
P
---
T
L
G
E
--
S
I
G
M
A
A
E
V
A
L
G
T
C
T
D
---
128
HHSearch
75.97
45%
-100
- C2 -
2EQ6
2
?
A:
[4-461]
------
M
K
T
Y
-
D
L
I
V
I
G
T
G
P
G
G
Y
H
A
A
I
R
A
A
Q
L
G
L
K
V
L
A
V
E
A
-------
G
------
E
-
V
G
G
V
C
L
N
V
G
C
I
P
T
K
A
L
L
-
H
A
A
E
-
T
L
H
H
L
K
-
V
-
A
-
E
---
G
---
F
-
G
L
K
-
A
---
K
P
E
L
D
L
K
K
L
G
G
W
R
D
Q
V
V
K
K
L
T
G
G
-
V
G
T
L
L
K
--
G
N
G
-
V
E
L
L
R
G
F
A
R
L
V
G
---------
P
K
E
V
E
V
-----------------------------
G
G
-
E
-------
R
-----
Y
G
A
K
S
L
I
L
A
T
G
S
E
P
L
--
E
L
K
G
F
P
--
F
---
G
-
E
-
D
-----
V
--
W
-
D
S
T
R
A
L
K
V
E
E
G
-
L
--
P
K
R
L
L
V
I
G
G
G
A
V
G
L
E
L
G
Q
V
Y
R
R
L
G
A
E
V
T
L
I
E
Y
M
P
E
I
L
P
Q
G
D
P
E
T
A
A
L
L
R
R
A
L
E
K
--
E
-
G
I
R
V
R
T
K
T
K
A
V
G
Y
E
K
K
-
K
D
G
--
L
H
V
R
L
-
E
PA
E
--
G
---
G
---
E
G
E
E
V
V
V
D
K
V
L
V
A
V
G
R
K
P
R
T
E
G
L
G
L
E
K
A
G
V
K
V
D
E
R
G
F
I
R
V
N
A
R
M
E
T
S
V
P
G
V
Y
A
I
G
D
---
A
A
R
-
P
-
P
-
L
L
A
H
K
A
M
R
E
G
L
I
A
A
E
-
N
A
A
G
K
D
--
S
A
-----
F
D
Y
-
Q
----
V
P
S
V
V
Y
T
S
P
E
W
A
G
V
G
L
T
E
E
E
A
K
R
A
G
-
Y
-
K
--
V
K
V
G
-
K
F
P
L
A
A
S
G
R
A
L
T
L
G
G
A
E
G
M
V
K
V
V
G
D
E
E
T
D
L
L
L
G
V
F
I
V
G
P
Q
-
A
G
E
L
I
A
E
A
A
L
A
L
E
M
G
A
T
L
T
D
L
A
L
T
V
H
P
H
P
---
T
L
S
E
--
S
L
M
E
A
A
E
A
F
H
K
Q
A
I
H
I
--
4
PsiBlast_PDB
75.41
45%
-99
- C2 -
2EQ6
2
?
A:
[4-462]
-------
M
K
T
Y
D
L
I
V
I
G
T
G
P
G
G
Y
H
A
A
I
R
A
A
Q
L
G
L
K
V
L
A
V
E
A
-------
G
------
E
-
V
G
G
V
C
L
N
V
G
C
I
P
T
K
A
L
L
-
H
A
A
E
-
T
L
H
H
L
K
-
V
-
A
-
E
---
G
---
F
-
G
L
K
-
A
-
K
-
P
-
E
L
D
L
K
K
L
G
G
W
R
D
Q
V
V
K
K
L
T
G
G
-
V
G
T
L
L
K
--
G
N
G
-
V
E
L
L
R
G
F
A
R
L
V
G
---------
P
K
E
V
E
V
------
G
G
-
E
-----------
R
------------------------
Y
G
A
K
S
L
I
L
A
T
G
S
E
P
L
--
E
L
K
G
F
P
--
F
---
G
-
E
-
D
-----
V
--
W
-
D
S
T
R
A
L
K
V
E
-
E
G
L
--
P
K
R
L
L
V
I
G
G
G
A
V
G
L
E
L
G
Q
V
Y
R
R
L
G
A
E
V
T
L
I
E
Y
M
P
E
I
L
P
Q
G
D
P
E
T
A
A
L
L
R
R
A
L
E
K
E
-
G
--
I
R
V
R
T
K
T
K
A
V
G
Y
E
K
K
-
K
D
G
--
L
H
V
R
L
-
E
PA
E
--
G
---
G
---
E
G
E
E
V
V
V
D
K
V
L
V
A
V
G
R
K
P
R
T
E
G
L
G
L
E
K
A
G
V
K
V
D
E
R
G
F
I
R
V
N
A
R
M
E
T
S
V
P
G
V
Y
A
I
G
D
---
A
A
R
-
P
-
P
-
L
L
A
H
K
A
M
R
E
G
L
I
A
A
E
-
N
A
A
G
K
D
--
S
A
-----
F
D
Y
Q
-----
V
P
S
V
V
Y
T
S
P
E
W
A
G
V
G
L
T
E
E
E
A
K
R
A
G
-
Y
-
K
--
V
K
V
G
-
K
F
P
L
A
A
S
G
R
A
L
T
L
G
G
A
E
G
M
V
K
V
V
G
D
E
E
T
D
L
L
L
G
V
F
I
V
G
P
Q
-
A
G
E
L
I
A
E
A
A
L
A
L
E
M
G
A
T
L
T
D
L
A
L
T
V
H
P
H
P
---
T
L
S
E
--
S
L
M
E
A
A
E
A
F
H
K
Q
A
I
H
I
L
-
89
PsiBlast_CBE
74.30
38%
-108
- C2 -
3II4
3
DLDH_MYCTU
B:
[7-466]
-----------
D
V
V
V
L
G
A
G
P
G
G
Y
V
A
A
I
R
A
A
Q
L
G
L
S
T
A
I
V
E
P
-------
K
------
Y
-
W
G
G
V
C
L
N
V
G
C
I
P
S
K
A
L
L
R
N
A
E
L
-
V
H
I
F
T
K
-
D
-
A
-
K
---
A
---
F
-
G
I
S
-
G
-
E
--
V
T
F
D
Y
G
I
A
Y
D
R
S
R
K
V
A
E
G
R
V
A
G
-
V
H
F
L
M
K
--
K
N
K
-
I
T
E
I
H
G
Y
G
T
F
A
D
---------
A
N
T
L
L
V
D-----
L
N
-
D
-----------
G
-------
G
T
-
E
-------
S
-----
V
T
F
D
N
A
I
I
A
T
G
S
S
T
R
--
L
V
P
G
T
S
--
L
---
S
-
A
-
N
-----
V
--
V
-
T
Y
E
E
Q
I
L
S
R
-
E
-
L
--
P
K
S
I
I
I
A
G
A
G
A
I
G
M
E
F
G
Y
V
L
K
N
Y
G
V
D
V
T
I
V
E
F
L
P
R
A
L
P
N
E
D
A
D
V
S
K
E
I
E
K
Q
F
K
K
L
-
G
--
V
T
I
L
T
A
T
K
V
E
S
I
A
D
G
-
G
S
Q
--
V
T
V
T
V
-
T
--
K
--
D
---
G
---
V
A
Q
E
L
K
A
E
K
V
L
Q
A
I
G
F
A
P
N
V
E
G
Y
G
L
D
K
A
G
V
A
L
T
D
R
K
A
I
G
V
D
D
Y
M
R
T
N
V
G
H
I
Y
A
I
G
D
---
V
N
G
-
L
-
L
-
Q
L
A
H
V
A
E
A
Q
G
V
V
A
A
E
-
T
I
A
G
----
A
E
-----
T
L
T
L
G
DHRM
L
P
R
A
T
F
C
Q
P
N
V
A
S
F
G
L
T
E
Q
Q
A
R
N
E
G
-
Y
-
D
--
V
V
V
A
-
K
F
P
F
T
A
N
A
K
A
H
G
V
G
D
P
S
G
F
V
K
L
V
A
D
A
K
H
G
E
L
L
G
G
H
L
V
G
H
D
-
V
A
E
L
L
P
E
L
T
L
A
Q
R
W
D
L
T
A
S
E
L
A
R
N
V
H
T
H
P
---
T
M
S
E
--
A
L
Q
E
C
F
H
G
L
V
G
H
M
I
N
F
--
131
HHSearch
73.93
43%
-101
- C2 -
2QAE
2
DLDH_TRYCR
A:
[1-465]
-------
N
P
Y
-
D
V
V
V
I
G
G
G
P
G
G
Y
V
A
S
I
K
A
A
Q
L
G
M
K
T
A
C
V
E
K
R------
G
------
A
-
L
G
G
T
C
L
N
V
G
C
I
P
S
K
A
L
L
-
H
A
T
H
-
L
Y
H
D
A
H
A
N
-
F
-
A
---
R
---
Y
-
G
L
M
G
G
-
E
-
G
V
T
M
D
S
A
K
M
Q
Q
Q
K
E
R
A
V
K
G
L
T
G
G
-
V
E
Y
L
F
K
--
K
N
K
-
V
T
Y
Y
K
G
E
G
S
F
E
T
---------
A
H
S
I
R
V
------
N
G
-
L
D----------
G
-------
K
Q
-
E
-------
M
-----
L
E
T
K
K
T
I
I
A
T
G
S
E
P
T
--
E
L
P
-
F
L
--
P
FD-
E
-
K
-
V
-----
V
--
L
-
S
S
T
G
A
L
A
L
P
-
R
-
V
--
P
K
T
M
V
V
I
G
G
G
V
I
G
L
E
L
G
S
V
W
A
R
L
G
A
E
V
T
V
V
E
F
A
P
R
C
A
P
T
L
D
E
D
V
T
N
A
L
V
G
A
L
A
K
N
-
E
-
K
M
K
F
M
T
S
T
K
V
V
G
G
T
N
N
-
G
D
S
--
V
S
L
E
V
-
E
---------
G
---
K
R
E
T
V
T
C
E
A
L
L
V
S
V
G
R
R
P
F
T
G
G
L
G
L
D
K
I
N
V
A
K
N
E
R
G
F
V
K
I
G
D
H
F
E
T
S
I
P
D
V
Y
A
I
G
D
---
V
V
D
-
K
G
P
-
M
L
A
H
K
A
E
D
E
G
V
A
C
A
E
-
I
L
A
G
K
P
--
G
H
-----
V
N
Y
G
V
----
I
P
A
V
I
Y
T
M
P
E
V
A
S
V
G
K
S
E
D
E
L
K
K
E
G
-
V
-
A
--
Y
K
V
G
-
K
F
P
F
N
A
N
S
R
A
K
A
V
S
T
E
D
G
F
V
K
V
L
V
D
K
A
T
D
R
I
L
G
V
H
I
V
C
T
T
-
A
G
E
L
I
G
E
A
C
L
A
M
E
Y
G
A
S
S
E
D
V
G
R
T
C
H
A
H
P
---
T
M
S
E
--
A
L
K
E
A
C
M
A
L
F
A
K
T
-----
90
PsiBlast_CBE
73.51
38%
-107
- C2 -
3II4
3
DLDH_MYCTU
A:
[7-466]
-----------
D
V
V
V
L
G
A
G
P
G
G
Y
V
A
A
I
R
A
A
Q
L
G
L
S
T
A
I
V
E
P
-------
K
------
Y
-
W
G
G
V
C
L
N
V
G
C
I
P
S
K
A
L
L
R
N
A
E
L
-
V
H
I
F
T
K
-
D
-
A
-
K
---
A
---
F
-
G
I
S
-
G
-
E
--
V
T
F
D
Y
G
I
A
Y
D
R
S
R
K
V
A
E
G
R
V
A
G
-
V
H
F
L
M
K
--
K
N
K
-
I
T
E
I
H
G
Y
G
T
F
A
D
---------
A
N
T
L
L
V
D-----
L
N
-
D
-----------
G
-------
G
T
-
E
-------
S
-----
V
T
F
D
N
A
I
I
A
T
G
S
S
T
R
--
L
V
P
G
T
S
--
L
---
S
-
A
-
N
-----
V
--
V
-
T
Y
E
E
Q
I
L
S
R
-
E
-
L
--
P
K
S
I
I
I
A
G
A
G
A
I
G
M
E
F
G
Y
V
L
K
N
Y
G
V
D
V
T
I
V
E
F
L
P
R
A
L
P
N
E
D
A
D
V
S
K
E
I
E
K
Q
F
K
K
L
-
G
--
V
T
I
L
T
A
T
K
V
E
S
I
A
D
G
-
G
S
Q
--
V
T
V
T
V
-
T
--
K
--
D
---
G
---
V
A
Q
E
L
K
A
E
K
V
L
Q
A
I
G
F
A
P
N
V
E
G
Y
G
L
D
K
A
G
V
A
L
T
D
R
K
A
I
G
V
D
D
Y
M
R
T
N
V
G
H
I
Y
A
I
G
D
---
V
N
G
-
L
-
L
-
Q
L
A
H
V
A
E
A
Q
G
V
V
A
A
E
-
T
I
A
G
----
A
E
-----
T
L
T
L
G
DHRM
L
P
R
A
T
F
C
Q
P
N
V
A
S
F
G
L
T
E
Q
Q
A
R
N
E
G
-
Y
-
D
--
V
V
V
A
-
K
F
P
F
T
A
N
A
K
A
H
G
V
G
D
P
S
G
F
V
K
L
V
A
D
A
K
H
G
E
L
L
G
G
H
L
V
G
H
D
-
V
A
E
L
L
P
E
L
T
L
A
Q
R
W
D
L
T
A
S
E
L
A
R
N
V
H
T
H
P
---
T
M
S
E
--
A
L
Q
E
C
F
H
G
L
V
G
H
M
I
N
F
--
138
HHSearch
73.37
37%
-104
- C2 -
2A8X
3
DLDH_MYCTU
A:
[1-461]
------
M
T
H
Y
-
D
V
V
V
L
G
A
G
P
G
G
Y
V
A
A
I
R
A
A
Q
L
G
L
S
T
A
I
V
E
P
-------
K
------
Y
-
W
G
G
V
C
L
N
V
G
C
I
P
S
K
A
L
L
-
R
N
A
E
-
L
V
H
I
F
T
K
D
-
A
-
K
---
A
---
F
-
G
I
S
---
G
-
E
V
T
F
D
Y
G
I
A
Y
D
R
S
R
K
V
A
E
G
R
V
A
G
-
V
H
F
L
M
K
--
K
N
K
-
I
T
E
I
H
G
Y
G
T
F
A
D
---------
A
N
T
L
L
V
------
D
L
-
N
D----------
G
-------
G
T
-
E
-------
S
-----
V
T
F
D
N
A
I
I
A
T
G
S
S
T
R
--
L
V
P
G
T
S
--
L
---
S
-
A
-
N
-----
V
--
V
-
T
Y
E
E
Q
I
L
S
R
-
E
-
L
--
P
K
S
I
I
I
A
G
A
G
A
I
G
M
E
F
G
Y
V
L
K
N
Y
G
V
D
V
T
I
V
E
F
L
P
R
A
L
P
N
E
D
A
D
V
S
K
E
I
E
K
Q
F
K
K
--
L
-
G
V
T
I
L
T
A
T
K
V
E
S
I
A
D
G
-
G
S
Q
--
V
T
V
T
V
-
T
--
K
--
D
---
G
---
V
A
Q
E
L
K
A
E
K
V
L
Q
A
I
G
F
A
P
N
V
E
G
Y
G
L
D
K
A
G
V
A
L
T
D
R
K
A
I
G
V
D
D
Y
M
R
T
N
V
G
H
I
Y
A
I
G
D
---
V
N
G
-
L
-
L
-
Q
L
A
H
V
A
E
A
Q
G
V
V
A
A
E
-
T
I
A
G
A
E
T
L
T
L
-----
G
D
H
R
M
----
L
P
R
A
T
F
C
Q
P
N
V
A
S
F
G
L
T
E
Q
Q
A
R
N
E
G
-
Y
-
D
--
V
V
V
A
-
K
F
P
F
T
A
N
A
K
A
H
G
V
G
D
P
S
G
F
V
K
L
V
A
D
A
K
H
G
E
L
L
G
G
H
L
V
G
H
D
-
V
A
E
L
L
P
E
L
T
L
A
Q
R
W
D
L
T
A
S
E
L
A
R
N
V
H
T
H
P
---
T
M
S
E
--
A
L
Q
E
C
F
H
G
L
V
G
H
M
-----
134
HHSearch
72.55
40%
-92
- C2 -
1V59
4
DLDH_YEAST
A:
[2-475]
-----
I
N
K
S
H
-
D
V
V
I
I
G
G
G
P
A
G
Y
V
A
A
I
K
A
A
Q
L
G
F
N
T
A
C
V
E
K
R------
G
------
K
-
L
G
G
T
C
L
N
V
G
C
I
P
S
K
A
L
L
-
N
N
S
H
-
L
F
H
Q
M
H
T
E
-
A
-
Q
---
K
---
R
-
G
I
D
-
V
N
G
-
D
I
K
I
N
V
A
N
F
Q
K
A
K
D
D
A
V
K
Q
L
T
G
G
-
I
E
L
L
F
K
--
K
N
K
-
V
T
Y
Y
K
G
N
G
S
F
E
D
---------
E
T
K
I
R
V
------
T
P
-
V
-----------
D
GLEGTVK
E
D
-
H
-------
I
-----
L
D
V
K
N
I
I
V
A
T
G
S
E
V
T
--
P
F
P
G
I
E
--
I
D--
E
-
E
-
K
-----
I
--
V
-
S
S
T
G
A
L
S
L
K
-
E
-
I
--
P
K
R
L
T
I
I
G
G
G
I
I
G
L
E
M
G
S
V
Y
S
R
L
G
S
K
V
T
V
V
E
F
Q
P
Q
I
G
A
S
M
D
G
E
V
A
K
A
T
Q
K
F
L
K
K
--
Q
-
G
L
D
F
K
L
S
T
K
V
I
S
A
K
R
N
-
D
D
K
N
V
V
E
I
V
V
-
E
--
D
TK
T
---
N
---
K
Q
E
N
L
E
A
E
V
L
L
V
A
V
G
R
R
P
Y
I
A
G
L
G
A
E
K
I
G
L
E
V
D
K
R
G
R
L
V
I
D
D
Q
F
N
S
K
F
P
H
I
K
V
V
G
D
---
V
T
F
-
G
-
P
-
M
L
A
H
K
A
E
E
E
G
I
A
A
V
E
-
M
L
K
T
G
H
--
G
H
-----
V
N
Y
N
N
----
I
P
S
V
M
Y
S
H
P
E
V
A
W
V
G
K
T
E
E
Q
L
K
E
A
G
-
I
-
D
--
Y
K
I
G
-
K
F
P
F
A
A
N
S
R
A
K
T
N
Q
D
T
E
G
F
V
K
I
L
I
D
S
K
T
E
R
I
L
G
A
H
I
I
G
P
N
-
A
G
E
M
I
A
E
A
G
L
A
L
E
Y
G
A
S
A
E
D
V
A
R
V
C
H
A
H
P
---
T
L
S
E
--
A
F
K
E
A
N
M
A
A
Y
D
K
A
-----
20
PsiBlast_PDB
70.95
44%
-103
- C2 -
1OJT
1
?
A:
[19-473]
----------------------
Y
S
A
A
F
A
A
A
D
E
G
L
K
V
A
I
V
E
R
Y------
K
------
T
-
L
G
G
V
C
L
N
V
G
C
I
P
S
K
A
L
L
-
H
N
A
A
-
V
I
D
E
V
R
-
H
-
L
-
A
---
A
---
N
-
G
I
K
-
Y
-
P
-
E
P
E
L
D
I
D
M
L
R
A
Y
K
D
G
V
V
S
R
L
T
G
G
-
L
A
G
M
A
K
--
S
R
K
-
V
D
V
I
Q
G
D
G
Q
F
L
D
---------
P
H
H
L
E
V
S
L
T
A
G
D
A
Y
-
E
-----------
Q
-------
A
A
-
P
-------
T
G
E
K
K
I
V
A
F
K
N
C
I
I
A
A
G
S
R
V
T
--
K
L
P
F
I
P
--
E
---
D
-
P
-
R
-----
I
--
I
-
D
S
S
G
A
L
A
L
K
-
E
-
V
--
P
G
K
L
L
I
I
G
G
G
I
I
G
L
E
M
G
T
V
Y
S
T
L
G
S
R
L
D
V
V
E
M
M
D
G
L
M
Q
G
A
D
R
D
L
V
K
V
W
Q
K
Q
N
E
Y
R
F
D
-
N
I
M
V
N
T
K
T
V
A
--
V
E
P
K
-
E
D
G
--
V
Y
V
T
F
-
E
G
-
A
--
N
---
A
---
P
K
E
P
Q
R
Y
D
A
V
L
V
A
A
G
R
A
P
N
G
K
L
I
S
A
E
K
A
G
V
A
V
T
D
R
G
F
I
E
V
D
K
Q
M
R
T
N
V
P
H
I
Y
A
I
G
D
---
I
V
G
-
Q
-
P
-
M
L
A
H
K
A
V
H
E
G
H
V
A
A
E
-
N
C
A
G
H
K
--
A
Y
-----
F
D
A
R
V
----
I
P
G
V
A
Y
T
S
P
E
V
A
W
V
G
E
T
E
L
S
A
K
A
S
A
-
R
-
K
--
I
T
K
A
-
N
F
P
W
A
A
S
G
R
A
I
A
N
G
C
D
K
P
F
T
K
L
I
F
D
A
E
T
G
R
I
I
G
G
G
I
V
G
P
N
-
G
G
D
M
I
G
E
V
C
L
A
I
E
M
G
C
D
A
A
D
I
G
K
T
I
H
P
H
P
---
T
L
G
E
--
S
I
G
M
A
A
E
V
A
L
G
T
------
79
PsiBlast_CBE
70.78
43%
-102
- C2 -
2QAE
2
DLDH_TRYCR
B:
[17-458]
------------------------
A
S
I
K
A
A
Q
L
G
M
K
T
A
C
V
E
K
R------
G
------
A
-
L
G
G
T
C
L
N
V
G
C
I
P
S
K
A
L
L
-
H
A
T
H
-
L
Y
H
D
A
--
H
-
A
-
N
FA-
R
---
Y
-
G
L
M
-
G
G
E
-
G
V
T
M
D
S
A
K
M
Q
Q
Q
K
E
R
A
V
K
G
L
T
G
G
-
V
E
Y
L
F
K
--
K
N
K
-
V
T
Y
Y
K
G
E
G
S
F
E
T
---------
A
H
S
I
R
V
------
N
G
-
L
-----------
D
-------
G
K
-
Q
E------
M
-----
L
E
T
K
K
T
I
I
A
T
G
S
E
P
T
--
E
L
P
F
L
P
--
F
---
D
-
E
-
K
-----
V
V-
L
-
S
S
T
G
A
L
A
L
P
-
R
-
V
--
P
K
T
M
V
V
I
G
G
G
V
I
G
L
E
L
G
S
V
W
A
R
L
G
A
E
V
T
V
V
E
F
A
P
R
C
A
P
T
L
D
E
D
V
T
N
A
L
V
G
A
L
A
K
N
-
E
-
K
M
K
F
M
T
S
T
K
V
V
G
G
T
N
N
-
G
D
S
--
V
S
L
E
V
-
E
---------
G
---
K
R
E
T
V
T
C
E
A
L
L
V
S
V
G
R
R
P
F
T
G
G
L
G
L
D
K
I
N
V
A
K
N
E
R
G
F
V
K
I
G
D
H
F
E
T
S
I
P
D
V
Y
A
I
G
D
---
V
V
D
K
G
-
P
-
M
L
A
H
K
A
E
D
E
G
V
A
C
A
E
-
I
L
A
G
K
P
--
G
H
-----
V
N
Y
G
V
----
I
P
A
V
I
Y
T
M
P
E
V
A
S
V
G
K
S
E
D
E
L
K
K
E
G
-
V
-
A
--
Y
K
V
G
-
K
F
P
F
N
A
N
S
R
A
K
A
V
S
T
E
D
G
F
V
K
V
L
V
D
K
A
T
D
R
I
L
G
V
H
I
V
C
T
T
-
A
G
E
L
I
G
E
A
C
L
A
M
E
Y
G
A
S
S
E
D
V
G
R
T
C
H
A
H
P
---
T
M
S
E
--
A
L
K
E
A
C
------------
18
PsiBlast_PDB
70.19
43%
-102
- C2 -
2QAE
2
DLDH_TRYCR
A:
[17-458]
------------------------
A
S
I
K
A
A
Q
L
G
M
K
T
A
C
V
E
K
R------
G
------
A
-
L
G
G
T
C
L
N
V
G
C
I
P
S
K
A
L
L
-
H
A
T
H
-
L
Y
H
D
A
--
H
-
A
-
N
FA-
R
---
Y
-
G
L
M
-
G
G
E
-
G
V
T
M
D
S
A
K
M
Q
Q
Q
K
E
R
A
V
K
G
L
T
G
G
-
V
E
Y
L
F
K
--
K
N
K
-
V
T
Y
Y
K
G
E
G
S
F
E
T
---------
A
H
S
I
R
V
------
N
G
-
L
-----------
D
-------
G
K
-
Q
E
------
M
-----
L
E
T
K
K
T
I
I
A
T
G
S
E
P
T
--
E
L
P
F
L
P
--
F
---
D
-
E
-
K
-----
V
V-
L
-
S
S
T
G
A
L
A
L
P
-
R
-
V
--
P
K
T
M
V
V
I
G
G
G
V
I
G
L
E
L
G
S
V
W
A
R
L
G
A
E
V
T
V
V
E
F
A
P
R
C
A
P
T
L
D
E
D
V
T
N
A
L
V
G
A
L
A
K
N
-
E
-
K
M
K
F
M
T
S
T
K
V
V
G
G
T
N
N
-
G
D
S
--
V
S
L
E
V
-
E
---------
G
---
K
R
E
T
V
T
C
E
A
L
L
V
S
V
G
R
R
P
F
T
G
G
L
G
L
D
K
I
N
V
A
K
N
E
R
G
F
V
K
I
G
D
H
F
E
T
S
I
P
D
V
Y
A
I
G
D
---
V
V
D
K
G
-
P
-
M
L
A
H
K
A
E
D
E
G
V
A
C
A
E
-
I
L
A
G
K
P
--
G
H
-----
V
N
Y
G
V
----
I
P
A
V
I
Y
T
M
P
E
V
A
S
V
G
K
S
E
D
E
L
K
K
E
G
-
V
-
A
--
Y
K
V
G
-
K
F
P
F
N
A
N
S
R
A
K
A
V
S
T
E
D
G
F
V
K
V
L
V
D
K
A
T
D
R
I
L
G
V
H
I
V
C
T
T
-
A
G
E
L
I
G
E
A
C
L
A
M
E
Y
G
A
S
S
E
D
V
G
R
T
C
H
A
H
P
---
T
M
S
E
--
A
L
K
E
A
C
------------
80
PsiBlast_CBE
69.89
44%
-102
- C2 -
1BHY
1
?
A:
[19-473]
----------------------
Y
S
A
A
F
A
A
A
D
E
G
L
K
V
A
I
V
E
R
Y------
K
------
T
-
L
G
G
V
C
L
N
V
G
C
I
P
S
K
A
L
L
-
H
N
A
A
-
V
I
D
E
V
R
-
H
-
L
-
A
---
A
---
N
-
G
I
K
-
Y
-
P
-
E
P
E
L
D
I
D
M
L
R
A
Y
K
D
G
V
V
S
R
L
T
G
G
-
L
A
G
M
A
K
--
S
R
K
-
V
D
V
I
Q
G
D
G
Q
F
L
D
---------
P
H
H
L
E
V
S
L
T
A
G
D
A
Y
-
E
-----------
Q
-------
A
A
-
P
-------
T
G
E
K
K
I
V
A
F
K
N
C
I
I
A
A
G
S
R
V
T
--
K
L
P
F
I
P
--
E
---
D
-
P
-
R
-----
I
--
I
-
D
S
S
G
A
L
A
L
K
-
E
-
V
--
P
G
K
L
L
I
I
G
G
G
I
I
G
L
E
M
G
T
V
Y
S
T
L
G
S
R
L
D
V
V
E
M
M
D
G
L
M
Q
G
A
D
R
D
L
V
K
V
W
Q
K
Q
N
E
Y
R
F
D
-
N
I
M
V
N
T
K
T
V
A
--
V
E
P
K
-
E
D
G
--
V
Y
V
T
F
-
E
G
-
A
--
N
---
A
---
P
K
E
P
Q
R
Y
D
A
V
L
V
A
A
G
R
A
P
N
G
K
L
I
S
A
E
K
A
G
V
A
V
T
D
R
G
F
I
E
V
D
K
Q
M
R
T
N
V
P
H
I
Y
A
I
G
D
---
I
V
G
-
Q
-
P
-
M
L
A
H
K
A
V
H
E
G
H
V
A
A
E
-
N
C
A
G
H
K
--
A
Y
-----
F
D
A
R
V
----
I
P
G
V
A
Y
T
S
P
E
V
A
W
V
G
E
T
E
L
S
A
K
A
S
A
-
R
-
K
--
I
T
K
A
-
N
F
P
W
A
A
S
G
R
A
I
A
N
G
C
D
K
P
F
T
K
L
I
F
D
A
E
T
G
R
I
I
G
G
G
I
V
G
P
N
-
G
G
D
M
I
G
E
V
Y
L
A
I
E
M
G
C
D
A
A
D
I
G
K
T
I
H
P
H
P
---
T
L
G
E
--
S
I
G
M
A
A
E
V
A
L
G
T
------
81
PsiBlast_CBE
69.80
39%
-87
- C2 -
1V59
3
DLDH_YEAST
B:
[7-477]
-----------
D
V
V
I
I
G
G
G
P
A
G
Y
V
A
A
I
K
A
A
Q
L
G
F
N
T
A
C
V
E
K
R------
G
------
K
-
L
G
G
T
C
L
N
V
G
C
I
P
S
K
A
L
L
-
N
N
S
H
-
L
F
H
Q
M
H
T
E
-
A
-
Q
---
K
---
R
-
G
I
D
-
V
-
N
G
D
I
K
I
N
V
A
N
F
Q
K
A
K
D
D
A
V
K
Q
L
T
G
G
-
I
E
L
L
F
K
--
K
N
K
-
V
T
Y
Y
K
G
N
G
S
F
E
D
---------
E
T
K
I
R
V
------
T
P
-
V
-----------
D
-------
G
L
-
E
GTVKEDH
I
-----
L
D
V
K
N
I
I
V
A
T
G
S
E
V
T
--
P
F
P
G
I
E
--
I
---
D
-
E
E
K
-----
I
--
V
-
S
S
T
G
A
L
S
L
K
-
E
-
I
--
P
K
R
L
T
I
I
G
G
G
I
I
G
L
E
M
G
S
V
Y
S
R
L
G
S
K
V
T
V
V
E
F
Q
P
Q
I
G
A
S
M
D
G
E
V
A
K
A
T
Q
K
F
L
K
K
Q
-
G
L
D
F
K
L
S
T
K
V
I
S
A
K
R
N
D
D
-
K
N
V
--
V
E
I
V
V
-
E
DT
K
--
T
---
N
---
K
Q
E
N
L
E
A
E
V
L
L
V
A
V
G
R
R
P
Y
I
A
G
L
G
A
E
K
I
G
L
E
V
D
K
R
G
R
L
V
I
D
D
Q
F
N
S
K
F
P
H
I
K
V
V
G
D
---
V
T
F
-
G
-
P
-
M
L
A
H
K
A
E
E
E
G
I
A
A
V
E
-
M
L
K
T
G
H
--
G
H
-----
V
N
Y
N
N
----
I
P
S
V
M
Y
S
H
P
E
V
A
W
V
G
K
T
E
E
Q
L
K
E
A
G
-
I
-
D
--
Y
K
I
G
-
K
F
P
F
A
A
N
S
R
A
K
T
N
Q
D
T
E
G
F
V
K
I
L
I
D
S
K
T
E
R
I
L
G
A
H
I
I
G
P
N
-
A
G
E
M
I
A
E
A
G
L
A
L
E
Y
G
A
S
A
E
D
V
A
R
V
C
H
A
H
P
---
T
L
S
E
--
A
F
K
E
A
N
M
A
A
Y
D
K
A
I
H
---
82
PsiBlast_CBE
69.63
39%
-88
- C2 -
1V59
4
DLDH_YEAST
A:
[7-477]
-----------
D
V
V
I
I
G
G
G
P
A
G
Y
V
A
A
I
K
A
A
Q
L
G
F
N
T
A
C
V
E
K
R------
G
------
K
-
L
G
G
T
C
L
N
V
G
C
I
P
S
K
A
L
L
-
N
N
S
H
-
L
F
H
Q
M
H
T
E
-
A
-
Q
---
K
---
R
-
G
I
D
-
V
-
N
G
D
I
K
I
N
V
A
N
F
Q
K
A
K
D
D
A
V
K
Q
L
T
G
G
-
I
E
L
L
F
K
--
K
N
K
-
V
T
Y
Y
K
G
N
G
S
F
E
D
---------
E
T
K
I
R
V
------
T
P
-
V
-----------
D
-------
G
L
-
E
GTVK
E
D
H
I
-----
L
D
V
K
N
I
I
V
A
T
G
S
E
V
T
--
P
F
P
G
I
E
--
I
---
D
-
E
E
K
-----
I
--
V
-
S
S
T
G
A
L
S
L
K
-
E
-
I
--
P
K
R
L
T
I
I
G
G
G
I
I
G
L
E
M
G
S
V
Y
S
R
L
G
S
K
V
T
V
V
E
F
Q
P
Q
I
G
A
S
M
D
G
E
V
A
K
A
T
Q
K
F
L
K
K
Q
-
G
L
D
F
K
L
S
T
K
V
I
S
A
K
R
N
D
D
-
K
N
V
--
V
E
I
V
V
-
E
DT
K
--
T
---
N
---
K
Q
E
N
L
E
A
E
V
L
L
V
A
V
G
R
R
P
Y
I
A
G
L
G
A
E
K
I
G
L
E
V
D
K
R
G
R
L
V
I
D
D
Q
F
N
S
K
F
P
H
I
K
V
V
G
D
---
V
T
F
-
G
-
P
-
M
L
A
H
K
A
E
E
E
G
I
A
A
V
E
-
M
L
K
T
G
H
--
G
H
-----
V
N
Y
N
N
----
I
P
S
V
M
Y
S
H
P
E
V
A
W
V
G
K
T
E
E
Q
L
K
E
A
G
-
I
-
D
--
Y
K
I
G
-
K
F
P
F
A
A
N
S
R
A
K
T
N
Q
D
T
E
G
F
V
K
I
L
I
D
S
K
T
E
R
I
L
G
A
H
I
I
G
P
N
-
A
G
E
M
I
A
E
A
G
L
A
L
E
Y
G
A
S
A
E
D
V
A
R
V
C
H
A
H
P
---
T
L
S
E
--
A
F
K
E
A
N
M
A
A
Y
D
K
A
I
H
---
83
PsiBlast_CBE
69.59
39%
-90
- C2 -
1JEH
2
DLDH_YEAST
B:
[7-477]
-----------
D
V
V
I
I
G
G
G
P
A
G
Y
V
A
A
I
K
A
A
Q
L
G
F
N
T
A
C
V
E
K
R------
G
------
K
-
L
G
G
T
C
L
N
V
G
C
I
P
S
K
A
L
L
-
N
N
S
H
-
L
F
H
Q
M
H
T
E
-
A
-
Q
---
K
---
R
-
G
I
D
-
V
-
N
G
D
I
K
I
N
V
A
N
F
Q
K
A
K
D
D
A
V
K
Q
L
T
G
G
-
I
E
L
L
F
K
--
K
N
K
-
V
T
Y
Y
K
G
N
G
S
F
E
D
---------
E
T
K
I
R
V
------
T
P
-
V
-----------
D
-------
G
L
-
E
GTVKEDH
I
-----
L
D
V
K
N
I
I
V
A
T
G
S
E
V
T
--
P
F
P
G
I
E
--
I
---
D
-
E
E
K
-----
I
--
V
-
S
S
T
G
A
L
S
L
K
-
E
-
I
--
P
K
R
L
T
I
I
G
G
G
I
I
G
L
E
M
G
S
V
Y
S
R
L
G
S
K
V
T
V
V
E
F
Q
P
Q
I
G
A
S
M
D
G
E
V
A
K
A
T
Q
K
F
L
K
K
Q
-
G
L
D
F
K
L
S
T
K
V
I
S
A
K
R
N
D
D
-
K
N
V
--
V
E
I
V
V
-
E
DT
K
--
T
---
N
---
K
Q
E
N
L
E
A
E
V
L
L
V
A
V
G
R
R
P
Y
I
A
G
L
G
A
E
K
I
G
L
E
V
D
K
R
G
R
L
V
I
D
D
Q
F
N
S
K
F
P
H
I
K
V
V
G
D
---
V
T
F
-
G
-
P
-
M
L
A
H
K
A
E
E
E
G
I
A
A
V
E
-
M
L
K
T
G
H
--
G
H
-----
V
N
Y
N
N
----
I
P
S
V
M
Y
S
H
P
E
V
A
W
V
G
K
T
E
E
Q
L
K
E
A
G
-
I
-
D
--
Y
K
I
G
-
K
F
P
F
A
A
N
S
R
A
K
T
N
Q
D
T
E
G
F
V
K
I
L
I
D
S
K
T
E
R
I
L
G
A
H
I
I
G
P
N
-
A
G
E
M
I
A
E
A
G
L
A
L
E
Y
G
A
S
A
E
D
V
A
R
V
C
H
A
H
P
---
T
L
S
E
--
A
F
K
E
A
N
M
A
A
Y
D
K
A
I
H
---
84
PsiBlast_CBE
68.92
39%
-87
- C2 -
1JEH
2
DLDH_YEAST
A:
[7-477]
-----------
D
V
V
I
I
G
G
G
P
A
G
Y
V
A
A
I
K
A
A
Q
L
G
F
N
T
A
C
V
E
K
R------
G
------
K
-
L
G
G
T
C
L
N
V
G
C
I
P
S
K
A
L
L
-
N
N
S
H
-
L
F
H
Q
M
H
T
E
-
A
-
Q
---
K
---
R
-
G
I
D
-
V
-
N
G
D
I
K
I
N
V
A
N
F
Q
K
A
K
D
D
A
V
K
Q
L
T
G
G
-
I
E
L
L
F
K
--
K
N
K
-
V
T
Y
Y
K
G
N
G
S
F
E
D
---------
E
T
K
I
R
V
------
T
P
-
V
-----------
D
-------
G
L
-
E
GTVK
E
D
H
I
-----
L
D
V
K
N
I
I
V
A
T
G
S
E
V
T
--
P
F
P
G
I
E
--
I
---
D
-
E
E
K
-----
I
--
V
-
S
S
T
G
A
L
S
L
K
-
E
-
I
--
P
K
R
L
T
I
I
G
G
G
I
I
G
L
E
M
G
S
V
Y
S
R
L
G
S
K
V
T
V
V
E
F
Q
P
Q
I
G
A
S
M
D
G
E
V
A
K
A
T
Q
K
F
L
K
K
Q
-
G
L
D
F
K
L
S
T
K
V
I
S
A
K
R
N
D
D
-
K
N
V
--
V
E
I
V
V
-
E
D
T
K
--
T
---
N
---
K
Q
E
N
L
E
A
E
V
L
L
V
A
V
G
R
R
P
Y
I
A
G
L
G
A
E
K
I
G
L
E
V
D
K
R
G
R
L
V
I
D
D
Q
F
N
S
K
F
P
H
I
K
V
V
G
D
---
V
T
F
-
G
-
P
-
M
L
A
H
K
A
E
E
E
G
I
A
A
V
E
-
M
L
K
T
G
H
--
G
H
-----
V
N
Y
N
N
----
I
P
S
V
M
Y
S
H
P
E
V
A
W
V
G
K
T
E
E
Q
L
K
E
A
G
-
I
-
D
--
Y
K
I
G
-
K
F
P
F
A
A
N
S
R
A
K
T
N
Q
D
T
E
G
F
V
K
I
L
I
D
S
K
T
E
R
I
L
G
A
H
I
I
G
P
N
-
A
G
E
M
I
A
E
A
G
L
A
L
E
Y
G
A
S
A
E
D
V
A
R
V
C
H
A
H
P
---
T
L
S
E
--
A
F
K
E
A
N
M
A
A
Y
D
K
A
I
H
---
98
PsiBlast_CBE
65.60
33%
-102
- C2 -
1ZX9
1
MERA_PSEAI
A:
[9-446]
--------------
V
I
G
S
G
G
A
A
M
A
A
A
L
K
A
V
E
Q
G
A
Q
V
T
L
I
E
R
-------
G
------
T
-
I
G
G
T
C
V
N
V
G
C
V
P
S
K
I
M
I
-
R
A
A
H
-
I
A
H
L
R
R
-
E
-
S
-
P
F--
D
---
G
-
G
I
A
-
A
-
T
-
V
P
T
I
D
R
S
K
L
L
A
Q
Q
Q
A
R
V
D
E
L
R
H
A
K
Y
E
G
I
L
G
--
G
N
P
A
I
T
V
V
H
G
E
A
R
F
K
D
---------
D
Q
S
L
T
V
R-----
L
N
-
E
-----------
G
-------
G
E
-
R
-------
V
-----
V
M
F
D
R
C
L
V
A
T
G
A
S
P
A
V
P
P
I
P
G
L
K
--
E
---
S
-
P
-------
Y
--
W
-
T
S
T
E
A
L
A
S
D
-
T
-
I
--
P
E
R
L
A
V
I
G
S
S
V
V
A
L
E
L
A
Q
A
F
A
R
L
G
S
K
V
T
V
L
-
A
R
N
T
L
F
F
R
E
D
P
A
I
G
E
A
V
T
A
A
F
R
A
E
-
G
--
I
E
V
L
E
H
T
Q
A
S
Q
V
A
H
M
--
D
G
--
E
F
V
L
T
-
T
--
T
--
H
---
G
---
E
L
R
---
A
D
K
L
L
V
A
T
G
R
T
P
N
T
R
S
L
A
L
D
A
A
G
V
T
V
N
A
Q
G
A
I
V
I
D
Q
G
M
R
T
S
N
P
N
I
Y
A
A
G
D
---
C
T
D
-
Q
-
P
-
Q
F
V
Y
V
A
A
A
A
G
T
R
A
A
I
-
N
M
T
G
G
D
--
A
A
-----
L
D
L
T
A
----
M
P
A
V
V
F
T
D
P
Q
V
A
T
V
G
Y
S
E
A
E
A
H
H
D
G
-
I
-
E
--
T
D
S
R
-
T
L
T
L
D
N
V
P
R
A
L
A
N
F
D
T
R
G
F
I
K
L
V
I
E
E
G
S
H
R
L
I
G
V
Q
A
V
A
P
E
-
A
G
E
L
I
Q
T
A
A
L
A
I
R
N
R
M
T
V
Q
E
L
A
D
Q
L
F
P
Y
L
---
T
M
V
E
--------------------
101
PsiBlast_CBE
65.55
33%
-102
- C2 -
4K7Z
22
MERA_PSEAI
A:
[9-446]
--------------
V
I
G
S
G
G
A
A
M
A
A
A
L
K
A
V
E
Q
G
A
Q
V
T
L
I
E
R
-------
G
------
T
-
I
G
G
T
A
V
N
V
G
A
V
P
S
K
I
M
I
-
R
A
A
H
-
I
A
H
L
R
R
-
E
-
S
-
P
F--
D
---
G
-
G
I
A
-
A
-
T
-
V
P
T
I
D
R
S
K
L
L
A
Q
Q
Q
A
R
V
D
E
L
R
H
A
K
Y
E
G
I
L
G
--
G
N
P
A
I
T
V
V
H
G
E
A
R
F
K
D
---------
D
Q
S
L
T
V
R-----
L
N
-
E
-----------
G
-------
G
E
-
R
-------
V
-----
V
M
F
D
R
C
L
V
A
T
G
A
S
P
A
V
P
P
I
P
G
L
K
--
E
---
S
-
P
-------
Y
--
W
-
T
S
T
E
A
L
A
S
D
-
T
-
I
--
P
E
R
L
A
V
I
G
S
S
V
V
A
L
E
L
A
Q
A
F
A
R
L
G
S
K
V
T
V
L
-
A
R
N
T
L
F
F
R
E
D
P
A
I
G
E
A
V
T
A
A
F
R
A
E
-
G
--
I
E
V
L
E
H
T
Q
A
S
Q
V
A
H
M
--
D
G
--
E
F
V
L
T
-
T
--
T
--
H
---
G
---
E
L
R
---
A
D
K
L
L
V
A
T
G
R
T
P
N
T
R
S
L
A
L
D
A
A
G
V
T
V
N
A
Q
G
A
I
V
I
D
Q
G
M
R
T
S
N
P
N
I
Y
A
A
G
D
---
C
T
D
-
Q
-
P
-
Q
F
V
Y
V
A
A
A
A
G
T
R
A
A
I
-
N
M
T
G
G
D
--
A
A
-----
L
D
L
T
A
----
M
P
A
V
V
F
T
D
P
Q
V
A
T
V
G
Y
S
E
A
E
A
H
H
D
G
-
I
-
E
--
T
D
S
R
-
T
L
T
L
D
N
V
P
R
A
L
A
N
F
D
T
R
G
F
I
K
L
V
I
E
E
G
S
H
R
L
I
G
V
Q
A
V
A
P
E
-
A
G
E
L
I
Q
T
A
A
L
A
I
R
N
R
M
T
V
Q
E
L
A
D
Q
L
F
P
Y
L
---
T
M
V
E
--------------------
100
PsiBlast_CBE
65.31
33%
-104
- C2 -
4K8D
20
MERA_PSEAI
A:
[9-446]
--------------
V
I
G
S
G
G
A
A
M
A
A
A
L
K
A
V
E
Q
G
A
Q
V
T
L
I
E
R
-------
G
------
T
-
I
G
G
T
C
V
N
V
G
C
V
P
S
K
I
M
I
-
R
A
A
H
-
I
A
H
L
R
R
-
E
-
S
-
P
F--
D
---
G
-
G
I
A
-
A
-
T
-
V
P
T
I
D
R
S
K
L
L
A
Q
Q
Q
A
R
V
D
E
L
R
H
A
K
Y
E
G
I
L
G
--
G
N
P
A
I
T
V
V
H
G
E
A
R
F
K
D
---------
D
Q
S
L
T
V
R-----
L
N
-
E
-----------
G
-------
G
E
-
R
-------
V
-----
V
M
F
D
R
C
L
V
A
T
G
A
S
P
A
V
P
P
I
P
G
L
K
--
E
---
S
-
P
-------
Y
--
W
-
T
S
T
E
A
L
A
S
D
-
T
-
I
--
P
E
R
L
A
V
I
G
S
S
V
V
A
L
E
L
A
Q
A
F
A
R
L
G
S
K
V
T
V
L
-
A
R
N
T
L
F
F
R
E
D
P
A
I
G
E
A
V
T
A
A
F
R
A
E
-
G
--
I
E
V
L
E
H
T
Q
A
S
Q
V
A
H
M
--
D
G
--
E
F
V
L
T
-
T
--
T
--
H
---
G
---
E
L
R
---
A
D
K
L
L
V
A
T
G
R
T
P
N
T
R
S
L
A
L
D
A
A
G
V
T
V
N
A
Q
G
A
I
V
I
D
Q
G
M
R
T
S
N
P
N
I
Y
A
A
G
D
---
C
T
D
-
Q
-
P
-
Q
F
V
Y
V
A
A
A
A
G
T
R
A
A
I
-
N
M
T
G
G
D
--
A
A
-----
L
D
L
T
A
----
M
P
A
V
V
F
T
D
P
Q
V
A
T
V
G
Y
S
E
A
E
A
H
H
D
G
-
I
-
E
--
T
D
S
R
-
T
L
T
L
D
N
V
P
R
A
L
A
N
F
D
T
R
G
F
I
K
L
V
I
E
E
G
S
H
R
L
I
G
V
Q
A
V
A
P
E
-
A
G
E
L
I
Q
T
A
A
L
A
I
R
N
R
M
T
V
Q
E
L
A
D
Q
L
F
P
Y
L
---
T
M
V
E
--------------------
99
PsiBlast_CBE
65.29
33%
-102
- C2 -
1ZK7
6
MERA_PSEAI
A:
[9-446]
--------------
V
I
G
S
G
G
A
A
M
A
A
A
L
K
A
V
E
Q
G
A
Q
V
T
L
I
E
R
-------
G
------
T
-
I
G
G
T
C
V
N
V
G
C
V
P
S
K
I
M
I
-
R
A
A
H
-
I
A
H
L
R
R
-
E
-
S
-
P
F--
D
---
G
-
G
I
A
-
A
-
T
-
V
P
T
I
D
R
S
K
L
L
A
Q
Q
Q
A
R
V
D
E
L
R
H
A
K
Y
E
G
I
L
G
--
G
N
P
A
I
T
V
V
H
G
E
A
R
F
K
D
---------
D
Q
S
L
T
V
R-----
L
N
-
E
-----------
G
-------
G
E
-
R
-------
V
-----
V
M
F
D
R
C
L
V
A
T
G
A
S
P
A
V
P
P
I
P
G
L
K
--
E
---
S
-
P
-------
Y
--
W
-
T
S
T
E
A
L
A
S
D
-
T
-
I
--
P
E
R
L
A
V
I
G
S
S
V
V
A
L
E
L
A
Q
A
F
A
R
L
G
S
K
V
T
V
L
-
A
R
N
T
L
F
F
R
E
D
P
A
I
G
E
A
V
T
A
A
F
R
A
E
-
G
--
I
E
V
L
E
H
T
Q
A
S
Q
V
A
H
M
--
D
G
--
E
F
V
L
T
-
T
--
T
--
H
---
G
---
E
L
R
---
A
D
K
L
L
V
A
T
G
R
T
P
N
T
R
S
L
A
L
D
A
A
G
V
T
V
N
A
Q
G
A
I
V
I
D
Q
G
M
R
T
S
N
P
N
I
Y
A
A
G
D
---
C
T
D
-
Q
-
P
-
Q
F
V
Y
V
A
A
A
A
G
T
R
A
A
I
-
N
M
T
G
G
D
--
A
A
-----
L
D
L
T
A
----
M
P
A
V
V
F
T
D
P
Q
V
A
T
V
G
Y
S
E
A
E
A
H
H
D
G
-
I
-
E
--
T
D
S
R
-
T
L
T
L
D
N
V
P
R
A
L
A
N
F
D
T
R
G
F
I
K
L
V
I
E
E
G
S
H
R
L
I
G
V
Q
A
V
A
P
E
-
A
G
E
L
I
Q
T
A
A
L
A
I
R
N
R
M
T
V
Q
E
L
A
D
Q
L
F
P
Y
L
---
T
M
V
E
--------------------
136
HHSearch
64.95
30%
-100
- C2 -
1GES
2
GSHR_ECOLI
A:
[3-449]
-------
K
H
Y
-
D
Y
I
A
I
G
G
G
S
G
G
I
A
S
I
N
R
A
A
M
Y
G
Q
K
C
A
L
I
E
A
-------
K
------
E
-
L
G
G
T
C
V
N
V
G
C
V
P
K
K
V
M
W
-
H
A
A
Q
-
I
R
E
A
I
H
-
M
-
Y
G
P
---
D
---
Y
-
G
F
D
-
T
-
T
-
I
N
K
F
N
W
E
T
L
I
A
S
R
T
A
Y
I
D
R
I
H
T
S
-
Y
E
N
V
L
G
--
K
N
N
-
V
D
V
I
K
G
F
A
R
F
V
D
---------
A
K
T
L
E
V
-----------------------------
N
G
-
E
-------
T
-----
I
T
A
D
H
I
L
I
A
T
G
G
R
P
S
--
H
P
D
-
I
P
--
G
---
V
-
E
-
Y
-----
G
--
I
-
D
S
D
G
F
F
A
L
P
-
A
-
L
--
P
E
R
V
A
V
V
G
A
G
Y
I
G
V
E
L
G
G
V
I
N
G
L
G
A
K
T
H
L
F
E
M
F
D
A
P
L
P
S
F
D
P
M
I
S
E
T
L
V
E
V
M
N
A
--
E
-
G
P
Q
L
H
T
N
A
I
P
K
A
V
V
K
N
T
D
G
S
--
L
T
L
E
L
-
E
-------------
D
G
R
S
E
T
V
D
C
L
I
W
A
I
G
R
E
P
A
N
D
N
I
N
L
E
A
A
G
V
K
T
N
E
K
G
Y
I
V
V
D
K
Y
Q
N
T
N
I
E
G
I
Y
A
V
G
D
---
N
T
G
-
A
-
V
-
E
L
T
P
V
A
V
A
A
G
R
R
L
S
E
-
R
L
F
N
N
K
PD
E
H
-----
L
D
Y
S
N
----
I
P
T
V
V
F
S
H
P
P
I
G
T
V
G
L
T
E
P
Q
A
R
E
Q
Y
G
D
D
Q
--
V
K
V
Y
-
K
S
S
F
T
A
M
Y
T
A
V
T
T
H
R
Q
P
C
R
M
K
L
V
C
V
G
S
E
E
K
I
V
G
I
H
G
I
G
F
G
-
M
D
E
M
L
Q
G
F
A
V
A
L
K
M
G
A
T
K
K
D
F
D
N
T
V
A
I
H
P
---
T
A
A
E
--
E
F
V
T
M
-------------
91
PsiBlast_CBE
62.91
31%
-98
- C2 -
2R9Z
7
GASHR_MARGR
B:
[6-455]
-----------
D
L
I
A
I
G
G
G
S
G
G
L
A
V
A
E
K
A
A
A
F
G
K
R
V
A
L
I
E
S
-------
K
------
A
-
L
G
G
T
C
V
N
V
G
C
V
P
K
K
V
M
W
-
Y
A
S
H
-
L
A
E
A
V
R
-
D
-
A
-
P
---
G
---
F
-
G
V
Q
-
A
-
S
-
G
-
T
L
D
W
P
R
L
V
A
G
R
D
R
Y
I
G
A
I
N
S
F
-
W
D
G
Y
V
E
--
R
L
G
-
I
T
R
V
D
G
H
A
R
F
V
D
---------
A
H
T
I
E
V
-----------------------------
E
G
-
Q
-------
R
-----
L
S
A
D
H
I
V
I
A
T
G
G
R
P
I
---
V
P
R
L
P
--
G
---
A
-
E
-
L
-----
G
--
I
-
T
S
D
G
F
F
A
L
Q
-
Q
-
Q
--
P
K
R
V
A
I
I
G
A
G
Y
I
G
I
E
L
A
G
L
L
R
S
F
G
S
E
V
T
V
V
A
L
E
D
R
L
L
F
Q
F
D
P
L
L
S
A
T
L
A
E
N
M
H
A
Q
-
G
--
I
E
T
H
L
E
F
A
V
A
A
L
E
R
D
-
A
Q
G
--
T
T
L
V
-----
A
--
Q
---
D
---
G
T
R
L
E
G
F
D
S
V
I
W
A
V
G
R
A
P
N
T
R
D
L
G
L
E
A
A
G
I
E
V
Q
S
N
G
M
V
P
T
D
A
Y
Q
N
T
N
V
P
G
V
Y
A
L
G
D
---
I
T
G
-
R
-
D
-
Q
L
T
P
V
A
I
A
A
G
R
R
L
A
E
-
R
L
F
D
G
Q
--
S
E
R
K
---
L
D
Y
D
N
----
I
P
T
V
V
F
A
H
P
P
L
S
K
V
G
L
S
E
P
E
A
R
E
R
L
-
G
-
D
--
V
L
T
V
Y
E
T
S
F
T
P
M
R
Y
A
L
N
E
H
G
P
K
T
A
M
K
L
V
C
A
G
P
E
Q
R
V
V
G
V
H
V
I
G
D
G
-
A
D
E
M
L
Q
G
F
A
V
A
V
K
M
G
A
T
K
A
D
F
D
N
T
V
A
I
H
P
---
G
S
A
E
E
L
V
T
L
K
E
P
V
R
R
P
G
-------
92
PsiBlast_CBE
62.43
31%
-100
- C2 -
2R9Z
7
GASHR_MARGR
A:
[6-455]
-----------
D
L
I
A
I
G
G
G
S
G
G
L
A
V
A
E
K
A
A
A
F
G
K
R
V
A
L
I
E
S
-------
K
------
A
-
L
G
G
T
C
V
N
V
G
C
V
P
K
K
V
M
W
-
Y
A
S
H
-
L
A
E
A
V
R
-
D
-
A
-
P
---
G
---
F
-
G
V
Q
-
A
-
S
----
L
D
W
P
R
L
V
A
G
R
D
R
Y
I
G
A
I
N
S
F
-
W
D
G
Y
V
E
--
R
L
G
-
I
T
R
V
D
G
H
A
R
F
V
D
---------
A
H
T
I
E
V
-----------------------------
E
G
-
Q
-------
R
-----
L
S
A
D
H
I
V
I
A
T
G
G
R
P
I
---
V
P
R
L
P
--
G
---
A
-
E
-
L
-----
G
--
I
-
T
S
D
G
F
F
A
L
Q
-
Q
-
Q
--
P
K
R
V
A
I
I
G
A
G
Y
I
G
I
E
L
A
G
L
L
R
S
F
G
S
E
V
T
V
V
A
L
E
D
R
L
L
F
Q
F
D
P
L
L
S
A
T
L
A
E
N
M
H
A
Q
-
G
--
I
E
T
H
L
E
F
A
V
A
A
L
E
R
D
-
A
Q
G
--
T
T
L
V
-----
A
--
Q
---
D
---
G
T
R
L
E
G
F
D
S
V
I
W
A
V
G
R
A
P
N
T
R
D
L
G
L
E
A
A
G
I
E
V
Q
S
N
G
M
V
P
T
D
A
Y
Q
N
T
N
V
P
G
V
Y
A
L
G
D
---
I
T
G
-
R
-
D
-
Q
L
T
P
V
A
I
A
A
G
R
R
L
A
E
-
R
L
F
D
G
Q
--
S
E
RK---
L
D
Y
D
N
----
I
P
T
V
V
F
A
H
P
P
L
S
K
V
G
L
S
E
P
E
A
R
E
R
L
-
G
-
D
--
V
L
T
V
Y
E
T
S
F
T
P
M
R
Y
A
L
N
E
H
G
P
K
T
A
M
K
L
V
C
A
G
P
E
Q
R
V
V
G
V
H
V
I
G
D
G
-
A
D
E
M
L
Q
G
F
A
V
A
V
K
M
G
A
T
K
A
D
F
D
N
T
V
A
I
H
P
---
G
S
A
E
E
L
V
T
L
K
E
P
V
R
R
P
G
-------
93
PsiBlast_CBE
58.69
32%
-94
- C2 -
4YWO
6
?
A:
[20-442]
--------------
I
I
G
Y
G
A
A
G
F
A
A
M
I
K
A
N
E
L
G
V
K
P
V
L
I
G
K
-------
G
------
E
-
I
G
G
T
C
V
N
V
G
C
V
P
S
K
R
M
L
-
Y
I
A
E
-
I
Y
K
K
A
R
-
E
--------------
V
T
-
G
-
S
-
E
V
Y
P
P
F
S
S
F
Q
E
K
D
G
L
V
Q
E
M
R
K
T
K
-
Y
E
D
L
L
S
--
Y
Y
D
-
V
E
L
I
Q
G
E
A
R
F
I
S
---------
P
H
A
V
K
V
-----------------------------
N
G
-
Q
-------
V
-----
I
E
A
E
K
F
V
I
A
T
G
S
S
P
L
---
I
P
R
I
P
--
G
---
L
-
D
-
K
-----
V
G
F
W
-
T
N
R
E
A
L
S
P
D
-
R
-
R
--
I
D
S
L
A
V
I
G
G
R
A
L
A
L
E
F
A
Q
M
Y
S
R
M
K
V
E
V
A
I
L
Q
R
S
P
V
L
I
P
D
W
E
P
E
-
A
S
V
E
A
R
R
I
M
E
N
-
D
-
G
V
A
V
V
T
G
V
N
V
K
E
V
R
K
G
-
A
G
K
--
I
V
I
T
D
-------
K
---
G
---
E
---
V
E
A
D
E
I
L
L
A
T
G
R
K
P
N
V
D
-
L
G
L
E
N
A
G
V
R
L
N
E
R
G
G
I
K
V
D
D
E
L
R
T
D
N
P
H
I
Y
A
A
G
D
---
V
L
G
-
G
-
K
-
M
L
E
A
L
A
G
R
Q
G
S
I
A
T
E
N
A
L
T
G
S
H
--
K
R
-----
V
D
E
N
A
----
V
P
Q
V
I
F
T
Q
P
N
L
A
R
V
G
L
T
E
A
E
A
R
A
K
E
-
G
-
E
--
V
E
A
R
-
V
L
P
M
S
S
V
A
K
A
E
I
I
N
S
R
L
G
F
V
K
M
V
T
M
--
N
G
R
I
V
G
V
H
A
V
G
E
N
-
V
A
E
M
I
G
E
A
A
L
A
I
R
F
G
A
T
V
H
D
L
I
D
T
V
H
M
F
P
---
T
I
A
E
--------------------
97
PsiBlast_CBE
56.86
31%
-92
- C2 -
1GES
2
GSHR_ECOLI
A:
[22-450]
---------------------------
R
A
A
M
Y
G
Q
K
C
A
L
I
E
A
-------
K
------
E
-
L
G
G
T
C
V
N
V
G
C
V
P
K
K
V
M
W
-
H
A
A
Q
I
R
E
A
I
H
M
-
Y
-
G
-
P
---
D
---
Y
-
G
F
D
-
T
-
T
-
I
N
K
F
N
W
E
T
L
I
A
S
R
T
A
Y
I
D
R
I
H
T
S
-
Y
E
N
V
L
G
--
K
N
N
-
V
D
V
I
K
G
F
A
R
F
V
D
---------
A
K
T
L
E
V
-----------------------------
N
G
-
E
-------
T
-----
I
T
A
D
H
I
L
I
A
T
G
G
R
P
S
--
H
-
P
D
I
P
--
G
---
V
-
E
-
Y
-----
G
--
I
-
D
S
D
G
F
F
A
L
P
-
A
-
L
--
P
E
R
V
A
V
V
G
A
G
Y
I
G
V
E
L
G
G
V
I
N
G
L
G
A
K
T
H
L
F
E
M
F
D
A
P
L
P
S
F
D
P
M
I
S
E
T
L
V
E
V
M
N
A
E
-
G
-
P
-
Q
L
H
T
N
A
I
P
K
A
V
V
K
N
-
T
D
G
---
S
L
T
L
-
E
--
L
--
E
D--
G
---
R
S
E
T
V
D
C
--
L
I
W
A
I
G
R
E
P
A
N
D
N
I
N
L
E
A
A
G
V
K
T
N
E
K
G
Y
I
V
V
D
K
Y
Q
N
T
N
I
E
G
I
Y
A
V
G
D
NTG
A
V
E
-
L
-
T
-
P
V
A
V
A
A
G
R
--
R
L
S
E
R
-
L
F
N
N
K
P
--
D
E
H----
L
D
Y
S
N
----
I
P
T
V
V
F
S
H
P
P
I
G
T
V
G
L
T
E
P
Q
A
R
E
Q
Y
-
G
-
D
DQ
V
K
V
Y
-
K
S
S
F
T
A
M
Y
T
A
V
T
T
H
R
Q
P
C
R
M
K
L
V
C
V
G
S
E
E
K
I
V
G
I
H
G
I
G
F
G
-
M
D
E
M
L
Q
G
F
A
V
A
L
K
M
G
A
T
K
K
D
F
D
N
T
V
A
I
H
P
---
T
A
A
E
EF
V
T
M
R
--------------
96
PsiBlast_CBE
56.83
31%
-90
- C2 -
1GES
2
GSHR_ECOLI
B:
[22-450]
---------------------------
R
A
A
M
Y
G
Q
K
C
A
L
I
E
A
-------
K
------
E
-
L
G
G
T
C
V
N
V
G
C
V
P
K
K
V
M
W
-
H
A
A
Q
I
R
E
A
I
H
M
-
Y
-
G
-
P
---
D
---
Y
-
G
F
D
-
T
-
T
-
I
N
K
F
N
W
E
T
L
I
A
S
R
T
A
Y
I
D
R
I
H
T
S
-
Y
E
N
V
L
G
--
K
N
N
-
V
D
V
I
K
G
F
A
R
F
V
D
---------
A
K
T
L
E
V
-----------------------------
N
G
-
E
-------
T
-----
I
T
A
D
H
I
L
I
A
T
G
G
R
P
S
--
H
-
P
D
I
P
--
G
---
V
-
E
-
Y
-----
G
--
I
-
D
S
D
G
F
F
A
L
P
-
A
-
L
--
P
E
R
V
A
V
V
G
A
G
Y
I
G
V
E
L
G
G
V
I
N
G
L
G
A
K
T
H
L
F
E
M
F
D
A
P
L
P
S
F
D
P
M
I
S
E
T
L
V
E
V
M
N
A
E
-
G
-
P
-
Q
L
H
T
N
A
I
P
K
A
V
V
K
N
-
T
D
G
---
S
L
T
L
-
E
--
L
--
E
D--
G
---
R
S
E
T
V
D
C
--
L
I
W
A
I
G
R
E
P
A
N
D
N
I
N
L
E
A
A
G
V
K
T
N
E
K
G
Y
I
V
V
D
K
Y
Q
N
T
N
I
E
G
I
Y
A
V
G
D
NTG
A
V
E
-
L
-
T
-
P
V
A
V
A
A
G
R
--
R
L
S
E
R
-
L
F
N
N
K
P
--
D
E
H----
L
D
Y
S
N
----
I
P
T
V
V
F
S
H
P
P
I
G
T
V
G
L
T
E
P
Q
A
R
E
Q
Y
-
G
-
D
DQ
V
K
V
Y
-
K
S
S
F
T
A
M
Y
T
A
V
T
T
H
R
Q
P
C
R
M
K
L
V
C
V
G
S
E
E
K
I
V
G
I
H
G
I
G
F
G
-
M
D
E
M
L
Q
G
F
A
V
A
L
K
M
G
A
T
K
K
D
F
D
N
T
V
A
I
H
P
---
T
A
A
E
EF
V
T
M
R
--------------
95
PsiBlast_CBE
55.62
31%
-89
- C2 -
1GEU
3
GSHR_ECOLI
A:
[22-450]
---------------------------
R
A
A
M
Y
G
Q
K
C
A
L
I
E
A
-------
K
------
E
-
L
G
G
T
C
V
N
V
G
C
V
P
K
K
V
M
W
-
H
A
A
Q
I
R
E
A
I
H
M
-
Y
-
G
-
P
---
D
---
Y
-
G
F
D
-
T
-
T
-
I
N
K
F
N
W
E
T
L
I
A
S
R
T
A
Y
I
D
R
I
H
T
S
-
Y
E
N
V
L
G
--
K
N
N
-
V
D
V
I
K
G
F
A
R
F
V
D
---------
A
K
T
L
E
V
-----------------------------
N
G
-
E
-------
T
-----
I
T
A
D
H
I
L
I
A
T
G
G
R
P
S
--
H
-
P
D
I
P
--
G
---
V
-
E
-
Y
-----
G
--
I
-
D
S
D
G
F
F
A
L
P
-
A
-
L
--
P
E
R
V
A
V
V
G
A
G
Y
I
G
V
E
L
G
G
V
I
N
G
L
G
A
K
T
H
L
F
E
M
F
D
A
P
L
P
S
F
D
P
M
I
S
E
T
L
V
E
V
M
N
A
E
-
G
-
P
-
Q
L
H
T
N
A
I
P
K
A
V
V
K
N
-
T
D
G
---
S
L
T
L
-
E
--
L
--
E
D--
G
---
R
S
E
T
V
D
C
--
L
I
W
A
I
G
R
E
P
A
N
D
N
I
N
L
E
A
A
G
V
K
T
N
E
K
G
Y
I
V
V
D
K
Y
Q
N
T
N
I
E
G
I
Y
A
V
G
D
NTG
A
V
E
-
L
-
T
-
P
V
A
V
A
A
G
R
--
R
L
S
E
R
-
L
F
N
N
K
P
--
D
E
H----
L
D
Y
S
N
----
I
P
T
V
V
F
S
H
P
P
I
G
T
V
G
L
T
E
P
Q
A
R
E
Q
Y
-
G
-
D
DQ
V
K
V
Y
-
K
S
S
F
T
A
M
Y
T
A
V
T
T
H
R
Q
P
C
R
M
K
L
V
C
V
G
S
E
E
K
I
V
G
I
H
G
I
G
F
G
-
M
D
E
M
L
Q
G
F
A
V
A
L
K
M
G
A
T
K
K
D
F
D
N
T
V
A
I
H
P
---
T
A
A
E
EF
V
T
M
R
--------------
94
PsiBlast_CBE
55.55
31%
-89
- C2 -
1GEU
3
GSHR_ECOLI
B:
[22-450]
---------------------------
R
A
A
M
Y
G
Q
K
C
A
L
I
E
A
-------
K
------
E
-
L
G
G
T
C
V
N
V
G
C
V
P
K
K
V
M
W
-
H
A
A
Q
I
R
E
A
I
H
M
-
Y
-
G
-
P
---
D
---
Y
-
G
F
D
-
T
-
T
-
I
N
K
F
N
W
E
T
L
I
A
S
R
T
A
Y
I
D
R
I
H
T
S
-
Y
E
N
V
L
G
--
K
N
N
-
V
D
V
I
K
G
F
A
R
F
V
D
---------
A
K
T
L
E
V
-----------------------------
N
G
-
E
-------
T
-----
I
T
A
D
H
I
L
I
A
T
G
G
R
P
S
--
H
-
P
D
I
P
--
G
---
V
-
E
-
Y
-----
G
--
I
-
D
S
D
G
F
F
A
L
P
-
A
-
L
--
P
E
R
V
A
V
V
G
A
G
Y
I
G
V
E
L
G
G
V
I
N
G
L
G
A
K
T
H
L
F
E
M
F
D
A
P
L
P
S
F
D
P
M
I
S
E
T
L
V
E
V
M
N
A
E
-
G
-
P
-
Q
L
H
T
N
A
I
P
K
A
V
V
K
N
-
T
D
G
---
S
L
T
L
-
E
--
L
--
E
D--
G
---
R
S
E
T
V
D
C
--
L
I
W
A
I
G
R
E
P
A
N
D
N
I
N
L
E
A
A
G
V
K
T
N
E
K
G
Y
I
V
V
D
K
Y
Q
N
T
N
I
E
G
I
Y
A
V
G
D
NTG
A
V
E
-
L
-
T
-
P
V
A
V
A
A
G
R
--
R
L
S
E
R
-
L
F
N
N
K
P
--
D
E
H----
L
D
Y
S
N
----
I
P
T
V
V
F
S
H
P
P
I
G
T
V
G
L
T
E
P
Q
A
R
E
Q
Y
-
G
-
D
DQ
V
K
V
Y
-
K
S
S
F
T
A
M
Y
T
A
V
T
T
H
R
Q
P
C
R
M
K
L
V
C
V
G
S
E
E
K
I
V
G
I
H
G
I
G
F
G
-
M
D
E
M
L
Q
G
F
A
V
A
L
K
M
G
A
T
K
K
D
F
D
N
T
V
A
I
H
P
---
T
A
A
E
EF
V
T
M
R
--------------