@TOME V2.3
(Nov 2016)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : bsu14610: (2016-06-22 )
MVVGDFPIETDTLVIGAGPGGYVAAIRAAQLGQKVTVVEKATLGGVCLNVGCIPSKALINAGHRYENAKHSDDMGITAENVTVDFTKVQEWKASVVNKLTGGVAGLLKGNKVDVVKGEAYFVDSNSVRVMDENSAQTYTFKNAIIATGSRPIELPNFKYSERVLNSTGALALKEIPKKLVVIGGGYIGTELGTAYANFGTELVILEGGDEILPGFEKQMSSLVTRRLKKKGNVEIHTNAMAKGVEERPDGVTVTFEVKGEEKTVDADYVLITVGRRPNTDELGLEQVGIEMTDRGIVKTDKQCRTNVPNIYAIGDIIEGPPLAHKASYEGKIAAEAIAGEPAEIDYLGIPAVVFSEPELASVGYTEAQAKEEGLDIVAAKFPFAANGRALSLNETDGFMKLITRKEDGLVIGAQIAGASASDMISELSLAIEGGMTAEDIAMTIHAHPTLGEITMEAAEVAIGSPIHIVK
Atome Classification :
(54 SA)
.........10.........20........30........40------.------.-.......50........-60..-......-70.-.---.---.-...-.-.-80........90........100-......--.110........120.---------......------130.-----------.-------..-.-------.-----..140.......150--......--.---160-.-----.--.-.....170.-.-.--....180.......190.......200.......210.......220.......230-........240.....-..250.....-.--.--.---.---260.......270.......280.......290.......300.......310...---...-.-320........330...-....340-..-----.....----.350.......360.......370.-.-.--....-380.......390.......400.......410.......-420.......430.......440......---.450--.......460.......470
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MVVGDFPIET-D
T
L
V
I
GAGPG
G
Y
V
A
A
I
R
A
A
QLG
Q
K
V
T
V
V
E
K-------A------T-LG
G
V
C
L
NVGCI
P
S
K
A
L
I-NAGH-RYENAK-H-S-D---D---M-
G
I
T
-A-E-
N
V
T
V
D
F
T
K
V
Q
E
W
K
A
S
V
V
N
K
L
T
G
G
-
V
A
G
LLK--GN
K
-
V
D
V
VKG
E
A
Y
F
VD---------SN
S
V
R
V
------MD-E-----------N-------SA-
Q
-------
T
-----
Y
T
F
K
N
A
I
IATGSRPI--ELPN
F
K
--
Y
---
S
-
E
-
R
-----
V
--
L
-NSTG
A
L
A
L
K
-E-I--PK
K
L
V
V
IGG
G
Y
IG
T
E
L
G
T
A
Y
ANFG
T
E
L
V
I
LEGGDEIL
P
G
F
E
K
Q
M
S
S
L
V
T
R
R
L
KKK-G-
N
V
E
I
H
T
N
A
M
AKGVEER-PD
G
--
V
T
V
T
F
-
E
--V--K---G---EEKTVDA
D
Y
V
L
I
T
VGRRPNTDEL
G
L
E
Q
VGIEMTDRGIVKTD
K
Q
CRTNVP
N
I
Y
A
IGD---IIE-G-P-PLAHKASYEG
K
I
A
A
E
-AIAGEP--A
E
-----
I
D
YLG----I
P
A
V
VFSEPELASVGYT
E
A
Q
AKEEG-
L
-
D
--
I
V
A
A-KFPFAAN
G
R
A
L
S
LNETD
G
F
M
K
L
I
TRKED
G
L
V
I
G
A
Q
IAGA
S
-
A
S
D
M
I
S
E
L
S
L
A
IEGGM
T
A
E
D
I
A
M
T
I
HAHP---T
L
G
E
--
I
T
M
E
A
A
E
V
AIGSP
I
H
IVK
21
PsiBlast_CBE
96.07
78%
-115
- C2 -
1EBD
2
DLDH1_GEOSE
B:
[2-455]
-------
I
E
T
-
E
T
L
V
V
G
A
G
P
G
G
Y
V
A
A
I
R
A
A
Q
L
G
Q
K
V
T
I
V
E
K
-------
G
------
N
-
L
G
G
V
C
L
N
V
G
C
I
P
S
K
A
L
I
-
S
A
S
H
-
R
Y
E
Q
A
K
-
H
-
S
-
E
---
E
---
M
-
G
I
K
-
A
-
E
-
N
V
T
I
D
F
A
K
V
Q
E
W
K
A
S
V
V
K
K
L
T
G
G
-
V
E
G
L
L
K
--
G
N
K
-
V
E
I
V
K
G
E
A
Y
F
V
D
---------
A
N
T
V
R
V
------
V
N
-
G
-----------
D
-------
S
A
-
Q
-------
T
-----
Y
T
F
K
N
A
I
I
A
T
G
S
R
P
I
--
E
L
P
N
F
K
--
F
---
S
-
N
-
R
-----
I
--
L
-
D
S
T
G
A
L
N
L
G
-
E
-
V
--
P
K
S
L
V
V
I
G
G
G
Y
I
G
I
E
L
G
T
A
Y
A
N
F
G
T
K
V
T
I
L
E
G
A
G
E
I
L
S
G
F
E
K
Q
M
A
A
I
I
K
K
R
L
K
K
K
-
G
--
V
E
V
V
T
N
A
L
A
K
G
A
E
E
R
-
E
D
G
--
V
T
V
T
Y
-
E
--
A
--
N
---
G
---
E
T
K
T
I
D
A
D
Y
V
L
V
T
V
G
R
R
P
N
T
D
E
L
G
L
E
Q
I
G
I
K
M
T
N
R
G
L
I
E
V
D
Q
Q
C
R
T
S
V
P
N
I
F
A
I
G
D
---
I
V
P
-
G
-
P
-
A
L
A
H
K
A
S
Y
E
G
K
V
A
A
E
-
A
I
A
G
H
P
--
S
A
-----
V
D
Y
V
A
----
I
P
A
V
V
F
S
D
P
E
C
A
S
V
G
Y
F
E
Q
Q
A
K
D
E
G
-
I
-
D
--
V
I
A
A
-
K
F
P
F
A
A
N
G
R
A
L
A
L
N
D
T
D
G
F
L
K
L
V
V
R
K
E
D
G
V
I
I
G
A
Q
I
I
G
P
N
-
A
S
D
M
I
A
E
L
G
L
A
I
E
A
G
M
T
A
E
D
I
A
L
T
I
H
A
H
P
---
T
L
G
E
--
I
A
M
E
A
A
E
V
A
L
--------
1
PsiBlast_PDB
95.69
78%
-117
- C2 -
1EBD
2
DLDH1_GEOSE
A:
[2-455]
-------
I
E
T
-
E
T
L
V
V
G
A
G
P
G
G
Y
V
A
A
I
R
A
A
Q
L
G
Q
K
V
T
I
V
E
K
-------
G
------
N
-
L
G
G
V
C
L
N
V
G
C
I
P
S
K
A
L
I
-
S
A
S
H
-
R
Y
E
Q
A
K
-
H
-
S
-
E
---
E
---
M
-
G
I
K
-
A
-
E
-
N
V
T
I
D
F
A
K
V
Q
E
W
K
A
S
V
V
K
K
L
T
G
G
-
V
E
G
L
L
K
--
G
N
K
-
V
E
I
V
K
G
E
A
Y
F
V
D
---------
A
N
T
V
R
V
------
V
N
-
G
-----------
D
-------
S
A
-
Q
-------
T
-----
Y
T
F
K
N
A
I
I
A
T
G
S
R
P
I
--
E
L
P
N
F
K
--
F
---
S
-
N
-
R
-----
I
--
L
-
D
S
T
G
A
L
N
L
G
-
E
-
V
--
P
K
S
L
V
V
I
G
G
G
Y
I
G
I
E
L
G
T
A
Y
A
N
F
G
T
K
V
T
I
L
E
G
A
G
E
I
L
S
G
F
E
K
Q
M
A
A
I
I
K
K
R
L
K
K
K
-
G
--
V
E
V
V
T
N
A
L
A
K
G
A
E
E
R
-
E
D
G
--
V
T
V
T
Y
-
E
--
A
--
N
---
G
---
E
T
K
T
I
D
A
D
Y
V
L
V
T
V
G
R
R
P
N
T
D
E
L
G
L
E
Q
I
G
I
K
M
T
N
R
G
L
I
E
V
D
Q
Q
C
R
T
S
V
P
N
I
F
A
I
G
D
---
I
V
P
-
G
-
P
-
A
L
A
H
K
A
S
Y
E
G
K
V
A
A
E
-
A
I
A
G
H
P
--
S
A
-----
V
D
Y
V
A
----
I
P
A
V
V
F
S
D
P
E
C
A
S
V
G
Y
F
E
Q
Q
A
K
D
E
G
-
I
-
D
--
V
I
A
A
-
K
F
P
F
A
A
N
G
R
A
L
A
L
N
D
T
D
G
F
L
K
L
V
V
R
K
E
D
G
V
I
I
G
A
Q
I
I
G
P
N
-
A
S
D
M
I
A
E
L
G
L
A
I
E
A
G
M
T
A
E
D
I
A
L
T
I
H
A
H
P
---
T
L
G
E
--
I
A
M
E
A
A
E
V
A
L
--------
135
HHSearch
95.41
78%
-117
- C2 -
1EBD
2
DLDH1_GEOSE
A:
[2-454]
-------
I
E
T
-
E
T
L
V
V
G
A
G
P
G
G
Y
V
A
A
I
R
A
A
Q
L
G
Q
K
V
T
I
V
E
K
-------
G
------
N
-
L
G
G
V
C
L
N
V
G
C
I
P
S
K
A
L
I
-
S
A
S
H
-
R
Y
E
Q
A
K
-
H
-
S
-
E
---
E
---
M
-
G
I
K
-
A
-
E
-
N
V
T
I
D
F
A
K
V
Q
E
W
K
A
S
V
V
K
K
L
T
G
G
-
V
E
G
L
L
K
--
G
N
K
-
V
E
I
V
K
G
E
A
Y
F
V
D
---------
A
N
T
V
R
V
------
V
N
-
G
-----------
D
-------
S
A
-
Q
-------
T
-----
Y
T
F
K
N
A
I
I
A
T
G
S
R
P
I
--
E
L
P
N
F
K
--
F
---
S
-
N
-
R
-----
I
--
L
-
D
S
T
G
A
L
N
L
G
-
E
-
V
--
P
K
S
L
V
V
I
G
G
G
Y
I
G
I
E
L
G
T
A
Y
A
N
F
G
T
K
V
T
I
L
E
G
A
G
E
I
L
S
G
F
E
K
Q
M
A
A
I
I
K
K
R
L
K
K
--
K
-
G
V
E
V
V
T
N
A
L
A
K
G
A
E
E
R
-
E
D
G
--
V
T
V
T
Y
-
E
--
A
--
N
---
G
---
E
T
K
T
I
D
A
D
Y
V
L
V
T
V
G
R
R
P
N
T
D
E
L
G
L
E
Q
I
G
I
K
M
T
N
R
G
L
I
E
V
D
Q
Q
C
R
T
S
V
P
N
I
F
A
I
G
D
---
I
V
P
-
G
-
P
-
A
L
A
H
K
A
S
Y
E
G
K
V
A
A
E
-
A
I
A
G
H
P
--
S
A
-----
V
D
Y
V
A
----
I
P
A
V
V
F
S
D
P
E
C
A
S
V
G
Y
F
E
Q
Q
A
K
D
E
G
-
I
-
D
--
V
I
A
A
-
K
F
P
F
A
A
N
G
R
A
L
A
L
N
D
T
D
G
F
L
K
L
V
V
R
K
E
D
G
V
I
I
G
A
Q
I
I
G
P
N
-
A
S
D
M
I
A
E
L
G
L
A
I
E
A
G
M
T
A
E
D
I
A
L
T
I
H
A
H
P
---
T
L
G
E
--
I
A
M
E
A
A
E
V
A
---------
112
Fugue
89.19
73%
-119
- C2 -
1EBD
2
DLDH1_GEOSE
A:
[1-455]
------
A
I
E
T
-
E
T
L
V
V
G
A
G
P
G
G
Y
V
A
A
I
R
A
A
Q
L
G
Q
K
V
T
I
V
E
K
-------
G
-------N
L
G
G
V
C
L
N
V
G
C
I
P
S
K
A
L
I
-
S
A
S
H
-
R
Y
E
Q
A
K
-
H
---
S
---
E
EMG
I
-
K
A
E
-----
N
V
T
I
D
F
A
K
V
Q
E
W
K
A
S
V
V
K
K
L
T
G
G
-
V
E
G
L
L
K
G
N
K
-
V
-
E
I
V
K
-
G
E
A
Y
F
V
-DAN
T
V
R
V
V
N
---------------
G
-----------
D
-------
S
A
-
Q
-------
T
-----
Y
T
F
K
N
A
I
I
A
T
G
S
R
P
I
--
E
L
P
N
F
K
--
F
---
S
----NRILD------
S
T
G
A
L
N
L
G
----EV
P
K
S
L
V
V
I
G
G
G
Y
I
G
I
E
L
G
T
A
Y
A
N
F
G
T
K
V
T
I
L
E
G
A
G
E
I
L
S
G
F
E
K
Q
M
A
A
I
I
K
K
R
L
K
K
K
-
G
--
V
E
V
V
T
N
A
L
A
K
G
A
E
E
R
-
E
-
D
--
G
V
T
V
T
-
Y
--
E
--
A
---
N
G
E
T
-
K
T
I
D
-
A
D
Y
V
L
V
T
V
G
R
R
P
N
T
D
E
L
G
L
E
Q
I
G
I
K
M
T
N
R
G
L
I
E
V
D
Q
Q
C
R
T
S
V
P
N
I
F
A
I
G
D
---
I
V
P
-
G
--P
A
L
A
H
K
A
S
Y
E
G
K
V
A
A
E
-
A
I
A
G
------HPSAV
D
Y
V
A
I
----
P
A
V
V
F
S
D
-
P
E
C
A
S
V
G
Y
F
E
Q
Q
A
K
D
E
G
-
I
-
D
--
V
I
A
A
-
K
F
P
F
A
A
N
G
R
A
L
A
L
N
D
T
D
G
F
L
K
L
V
V
R
K
E
D
G
V
I
I
G
A
Q
I
I
G
-
P
N
A
S
D
M
I
A
E
L
G
L
A
I
E
A
G
M
T
A
E
D
I
A
L
T
--
I
H
A
H
PT-
L
G
E
--
I
A
M
E
A
A
E
V
A
L
--------
15
PsiBlast_PDB
80.20
41%
-126
- C2 -
1LVL
2
DLDH1_PSEPU
A:
[4-458]
-------
I
Q
T
-
T
L
L
I
I
G
G
G
P
G
G
Y
V
A
A
I
R
A
G
Q
L
G
I
P
T
V
L
V
E
G
-------
Q
------
A
-
L
G
G
T
C
L
N
I
G
C
I
P
S
K
A
L
I
-
H
V
A
E
-
Q
F
H
Q
A
S
-
R
-
F
-
T
---
E
PSP
L
-
G
I
S
-
V
-
A
-
S
P
R
L
D
I
G
Q
S
V
A
W
K
D
G
I
V
D
R
L
T
T
G
-
V
A
A
L
L
K
--
K
H
G
-
V
K
V
V
H
G
W
A
K
V
L
D
---------
G
K
Q
V
E
V
-----------------------------
D
G
-
Q
-------
R
-----
I
Q
C
E
H
L
L
L
A
T
G
S
S
S
V
--
E
L
P
M
L
P
--
L
---
G
-
G
-
P
-----
V
--
I
-
S
S
T
E
A
L
A
P
K
-
A
-
L
--
P
Q
H
L
V
V
V
G
G
G
Y
I
G
L
E
L
G
I
A
Y
R
K
L
G
A
Q
V
S
V
V
E
A
R
E
R
I
L
P
T
Y
D
S
E
L
T
A
P
V
A
E
S
L
K
K
L
-
G
--
I
A
L
H
L
G
H
S
V
E
G
Y
E
----
N
G
--
C
L
L
A
N
-
D
--
G
--
K
---
G
---
G
Q
L
R
L
E
A
D
R
V
L
V
A
V
G
R
R
P
R
T
K
G
F
N
L
E
C
L
D
L
K
M
N
G
A
A
I
A
-
I
D
E
R
C
Q
T
S
M
H
N
V
W
A
I
G
D
---
V
A
G
-
E
-
P
-
M
L
A
H
R
A
M
A
Q
G
E
M
V
A
E
-
I
I
A
G
K
A
--
R
R
-----
F
E
P
A
A
----
I
A
A
V
C
F
T
D
P
E
V
V
V
V
G
K
T
P
E
Q
A
S
Q
Q
G
-
L
-
D
--
C
I
V
A
-
Q
F
P
F
A
A
N
G
R
A
M
S
L
E
S
K
S
G
F
V
R
V
V
A
R
R
D
N
H
L
I
L
G
W
Q
A
V
G
V
A
-
V
S
E
L
S
T
A
F
A
Q
S
L
E
M
G
A
C
L
E
D
V
A
G
T
I
H
A
H
P
---
T
L
G
E
--
A
V
Q
E
A
A
L
R
A
L
G
H
A
L
H
I
--
22
PsiBlast_CBE
79.83
47%
-107
- C2 -
4JQ9
19
?
F:
[5-462]
-------
I
K
T
-
Q
V
V
V
L
G
A
G
P
A
G
Y
S
A
A
F
R
C
A
D
L
G
L
E
T
V
I
V
E
R
-------
Y
N-----
T
-
L
G
G
V
C
L
N
V
G
C
I
P
S
K
A
L
L
-
H
V
A
K
-
V
I
E
E
A
K
-
A
-
L
-
A
---
E
---
H
-
G
I
V
-
F
-
G
-
E
P
K
T
D
I
D
K
I
R
T
W
K
E
K
V
I
N
Q
L
T
G
G
-
L
A
G
M
A
K
--
G
R
K
-
V
K
V
V
N
G
L
G
K
F
T
G
---------
A
N
T
L
E
V
------
E
G
-
E
-----------
N
-------
G
K
-
T
-------
V
-----
I
N
F
D
N
A
I
I
A
A
G
S
R
P
I
--
Q
L
P
F
I
P
--
H
---
E
-
D
P
R
-----
I
--
W
-
D
S
T
D
A
L
E
L
K
-
E
-
V
--
P
E
R
L
L
V
M
G
G
G
I
I
G
L
E
M
G
T
V
Y
H
A
L
G
S
Q
I
D
V
V
E
M
F
D
Q
V
I
P
A
A
D
K
D
I
V
K
V
F
T
K
R
I
S
K
K
-
F
-
N
L
M
L
E
T
K
V
T
A
--
V
E
A
K
-
E
D
G
--
I
Y
V
T
M
-
E
--
G
--
K
KAP
A
---
E
P
Q
R
Y
D
A
--
V
L
V
A
I
G
R
V
P
N
G
K
N
L
D
A
G
K
A
G
V
E
V
D
D
R
G
F
I
R
V
D
K
Q
L
R
T
N
V
P
H
I
F
A
I
G
D
---
I
V
G
-
Q
-
P
-
M
L
A
H
K
G
V
H
E
G
H
V
A
A
E
-
V
I
A
G
K
K
--
H
Y
-----
F
D
P
K
V
----
I
P
S
I
A
Y
T
E
P
E
V
A
W
V
G
L
T
E
K
E
A
K
E
K
G
-
I
-
S
--
Y
E
T
A
-
T
F
P
W
A
A
S
G
R
A
I
A
S
D
C
A
D
G
M
T
K
L
I
F
D
K
E
S
H
R
V
I
G
G
A
I
V
G
T
N
-
G
G
E
L
L
G
E
I
G
L
A
I
E
M
G
C
D
A
E
D
I
A
L
T
I
H
A
H
P
---
T
L
H
E
--
S
V
G
L
A
A
E
V
F
E
G
S
------
122
HHSearch
79.79
42%
-125
- C2 -
1LVL
2
DLDH1_PSEPU
A:
[1-458]
----
Q
Q
T
I
Q
T
-
T
L
L
I
I
G
G
G
P
G
G
Y
V
A
A
I
R
A
G
Q
L
G
I
P
T
V
L
V
E
G
-------
Q
------
A
-
L
G
G
T
C
L
N
I
G
C
I
P
S
K
A
L
I
-
H
V
A
E
-
Q
F
H
Q
A
S
-
R
-
F
-
T
E
PS
P
---
L
-
G
I
S
-
V
-
A
-
S
P
R
L
D
I
G
Q
S
V
A
W
K
D
G
I
V
D
R
L
T
T
G
-
V
A
A
L
L
K
--
K
H
G
-
V
K
V
V
H
G
W
A
K
V
L
D
---------
G
K
Q
V
E
V
------
D
-----------------------
G
-
Q
-------
R
-----
I
Q
C
E
H
L
L
L
A
T
G
S
S
S
V
--
E
L
P
-
M
L
--
P
L--
G
-
G
-
P
-----
V
--
I
-
S
S
T
E
A
L
A
P
K
-
A
-
L
--
P
Q
H
L
V
V
V
G
G
G
Y
I
G
L
E
L
G
I
A
Y
R
K
L
G
A
Q
V
S
V
V
E
A
R
E
R
I
L
P
T
Y
D
S
E
L
T
A
P
V
A
E
S
L
K
K
--
L
-
G
I
A
L
H
L
G
H
S
V
E
G
Y
E
N
G
-------
C
L
L
A
-
N
--
D
--
G
K--
G
---
G
Q
L
R
L
E
A
D
R
V
L
V
A
V
G
R
R
P
R
T
K
G
F
N
L
E
C
L
D
L
K
M
N
-
G
A
A
I
A
I
D
E
R
C
Q
T
S
M
H
N
V
W
A
I
G
D
---
V
A
G
-
E
-
P
-
M
L
A
H
R
A
M
A
Q
G
E
M
V
A
E
-
I
I
A
G
K
A
--
R
R
-----
F
E
P
A
A
----
I
A
A
V
C
F
T
D
P
E
V
V
V
V
G
K
T
P
E
Q
A
S
Q
Q
G
-
L
-
D
--
C
I
V
A
-
Q
F
P
F
A
A
N
G
R
A
M
S
L
E
S
K
S
G
F
V
R
V
V
A
R
R
D
N
H
L
I
L
G
W
Q
A
V
G
V
A
-
V
S
E
L
S
T
A
F
A
Q
S
L
E
M
G
A
C
L
E
D
V
A
G
T
I
H
A
H
P
---
T
L
G
E
--
A
V
Q
E
A
A
L
R
A
L
G
H
A
L
H
I
--
3
PsiBlast_PDB
79.73
47%
-110
- C2 -
4JQ9
14
?
A:
[5-462]
-------
I
K
T
-
Q
V
V
V
L
G
A
G
P
A
G
Y
S
A
A
F
R
C
A
D
L
G
L
E
T
V
I
V
E
R
-------
Y
N-----
T
-
L
G
G
V
C
L
N
V
G
C
I
P
S
K
A
L
L
-
H
V
A
K
-
V
I
E
E
A
K
-
A
-
L
-
A
---
E
---
H
-
G
I
V
-
F
-
G
-
E
P
K
T
D
I
D
K
I
R
T
W
K
E
K
V
I
N
Q
L
T
G
G
-
L
A
G
M
A
K
--
G
R
K
-
V
K
V
V
N
G
L
G
K
F
T
G
---------
A
N
T
L
E
V
------
E
G
-
E
-----------
N
-------
G
K
-
T
-------
V
-----
I
N
F
D
N
A
I
I
A
A
G
S
R
P
I
--
Q
L
P
F
I
P
--
H
---
E
-
D
P
R
-----
I
--
W
-
D
S
T
D
A
L
E
L
K
-
E
-
V
--
P
E
R
L
L
V
M
G
G
G
I
I
G
L
E
M
G
T
V
Y
H
A
L
G
S
Q
I
D
V
V
E
M
F
D
Q
V
I
P
A
A
D
K
D
I
V
K
V
F
T
K
R
I
S
K
K
-
F
-
N
L
M
L
E
T
K
V
T
A
--
V
E
A
K
-
E
D
G
--
I
Y
V
T
M
-
E
--
G
--
K
KAP
A
---
E
P
Q
R
Y
D
A
--
V
L
V
A
I
G
R
V
P
N
G
K
N
L
D
A
G
K
A
G
V
E
V
D
D
R
G
F
I
R
V
D
K
Q
L
R
T
N
V
P
H
I
F
A
I
G
D
---
I
V
G
-
Q
-
P
-
M
L
A
H
K
G
V
H
E
G
H
V
A
A
E
-
V
I
A
G
K
K
--
H
Y
-----
F
D
P
K
V
----
I
P
S
I
A
Y
T
E
P
E
V
A
W
V
G
L
T
E
K
E
A
K
E
K
G
-
I
-
S
--
Y
E
T
A
-
T
F
P
W
A
A
S
G
R
A
I
A
S
D
C
A
D
G
M
T
K
L
I
F
D
K
E
S
H
R
V
I
G
G
A
I
V
G
T
N
-
G
G
E
L
L
G
E
I
G
L
A
I
E
M
G
C
D
A
E
D
I
A
L
T
I
H
A
H
P
---
T
L
H
E
--
S
V
G
L
A
A
E
V
F
E
G
S
------
17
PsiBlast_PDB
79.67
43%
-112
- C2 -
2YQU
4
?
A:
[3-455]
-----------
D
L
L
V
I
G
A
G
P
G
G
Y
V
A
A
I
R
A
A
Q
L
G
M
K
V
G
V
V
E
K
E------
K
------
A
-
L
G
G
T
C
L
R
V
G
C
I
P
S
K
A
L
L
-
E
T
T
E
-
R
I
Y
E
A
K
---
K
-
G
---
L
---
L
-
G
A
K
-
V
-
K
-
G
V
E
L
D
L
P
A
L
M
A
H
K
D
K
V
V
Q
A
N
T
Q
G
-
V
E
F
L
F
K
--
K
N
G
-
I
A
R
H
Q
G
T
A
R
F
L
S
---------
E
R
--
K
V
------
L
V
-
E
-----------
E
-------
T
G
-
E
-------
E
-----
L
E
A
R
Y
I
L
I
A
T
G
S
A
P
L
--
I
P
P
W
A
Q
--
V
---
D
Y
E
-
R
-----
V
--
V
-
T
S
T
E
A
L
S
F
P
-
E
-
V
--
P
K
R
L
I
V
V
G
G
G
V
I
G
L
E
L
G
V
V
W
H
R
L
G
A
E
V
I
V
L
E
Y
M
D
R
I
L
P
T
M
D
L
E
V
S
R
A
A
E
R
V
F
K
K
Q
-
G
--
L
T
I
R
T
G
V
R
V
T
A
V
V
P
E
-
A
K
G
--
A
R
V
---
E
--
L
--
E
---
G
---
G
E
-
V
L
E
A
D
R
V
L
V
A
V
G
R
R
P
Y
T
E
G
L
S
L
E
N
A
G
L
S
T
D
E
R
G
R
I
P
V
D
E
H
L
R
T
R
V
P
H
I
Y
A
I
G
D
---
V
V
R
-
G
-
P
-
M
L
A
H
K
A
S
E
E
G
I
A
A
V
E
-
H
M
V
R
G
F
--
G
H
-----
V
D
Y
Q
A
----
I
P
S
V
V
Y
T
H
P
E
I
A
A
V
G
Y
T
E
E
E
L
K
A
Q
G
-
I
-
P
--
Y
K
V
G
-
K
F
P
Y
S
A
S
G
R
A
R
A
M
G
E
T
E
G
F
I
K
V
L
A
H
A
K
T
D
R
I
L
G
V
H
G
I
G
A
R
-
V
G
D
V
L
A
E
A
A
L
A
L
F
F
K
A
S
A
E
D
L
G
R
A
P
H
A
H
P
---
S
L
S
E
--
I
L
K
E
A
A
L
A
A
W
E
R
P
I
H
L
--
13
PsiBlast_PDB
78.82
41%
-112
- C2 -
3LAD
2
DLDH_AZOVI
A:
[5-471]
-----------
D
V
I
V
I
G
A
G
P
G
G
Y
V
A
A
I
K
S
A
Q
L
G
L
K
T
A
L
I
E
K
YKGKEGK
T
------
A
-
L
G
G
T
C
L
N
V
G
C
I
P
S
K
A
L
L
-
D
S
S
Y
-
K
F
H
E
A
H
-
E
-
S
-
F
---
K
---
L
H
G
I
S
-
T
-
G
-
E
V
A
I
D
V
P
T
M
I
A
R
K
D
Q
I
V
R
N
L
T
G
G
-
V
A
S
L
I
K
--
A
N
G
-
V
T
L
F
E
G
H
G
K
L
L
A
---------
G
K
K
V
E
V
------
T
A
A
D
-----------
G
-------
S
S
-
Q
-------
V
-----
L
D
T
E
N
V
I
L
A
S
G
S
K
P
V
--
E
I
P
P
A
P
--
V
---
D
-
Q
-
D
-----
V
--
I
V
D
S
T
G
A
L
D
F
Q
-
N
-
V
--
P
G
K
L
G
V
I
G
A
G
V
I
G
L
E
L
G
S
V
W
A
R
L
G
A
E
V
T
V
L
E
A
M
D
K
F
L
P
A
V
D
E
Q
V
A
K
E
A
Q
K
I
L
T
K
Q
-
G
--
L
K
I
L
L
G
A
R
V
T
G
T
E
V
K
-
N
K
Q
--
V
T
V
K
F
-
V
--
D
--
A
---
E
---
G
E
K
S
Q
A
F
D
K
L
I
V
A
V
G
R
R
P
V
T
T
D
L
L
A
A
D
S
G
V
T
L
D
E
R
G
F
I
Y
V
D
D
Y
C
A
T
S
V
P
G
V
Y
A
I
G
D
---
V
V
R
-
G
-
A
-
M
L
A
H
K
A
S
E
E
G
V
V
V
A
E
-
R
I
A
G
H
K
--
A
Q
-----
M
N
Y
D
L
----
I
P
A
V
I
Y
T
H
P
E
I
A
G
V
G
K
T
E
Q
A
L
K
A
E
G
-
V
-
A
--
I
N
V
G
-
V
F
P
F
A
A
S
G
R
A
M
A
A
N
D
T
A
G
F
V
K
V
I
A
D
A
K
T
D
R
V
L
G
V
H
V
I
G
P
S
-
A
A
E
L
V
Q
Q
G
A
I
A
M
E
F
G
T
S
A
E
D
L
G
M
M
V
F
A
H
P
---
A
L
S
E
--
A
L
H
E
A
A
L
A
V
S
G
H
A
I
H
V
--
7
PsiBlast_PDB
78.58
42%
-105
- C2 -
1LPF
2
DLDH_PSEFL
A:
[5-471]
-----------
D
V
V
V
I
G
A
G
P
G
G
Y
V
A
A
I
R
A
A
Q
L
G
L
K
T
A
C
I
E
K
YIGKEGK
V
------
A
-
L
G
G
T
C
L
N
V
G
C
I
P
S
K
A
L
L
-
D
S
S
Y
-
K
Y
H
E
A
K
-
E
-
A
-
F
---
K
---
V
H
G
I
E
-
A
-
K
-
G
V
T
I
D
V
P
A
M
V
A
R
K
A
N
I
V
K
N
L
T
G
G
-
I
A
T
L
F
K
--
A
N
G
-
V
T
S
F
E
G
H
G
K
L
L
A
---------
N
K
Q
V
E
V
------
T
G
L
D
-----------
G
-------
K
T
-
Q
-------
V
-----
L
E
A
E
N
V
I
I
A
S
G
S
R
P
V
--
E
I
P
P
A
P
--
L
---
S
-
D
-
D
-----
I
--
I
V
D
S
T
G
A
L
E
F
Q
-
A
-
V
--
P
K
K
L
G
V
I
G
A
G
V
I
G
L
E
L
G
S
V
W
A
R
L
G
A
E
V
T
V
L
E
A
L
D
K
F
L
P
A
A
D
E
Q
I
A
K
E
A
L
K
V
L
T
K
Q
-
G
--
L
N
I
R
L
G
A
R
V
T
A
S
E
V
K
-
K
K
Q
--
V
T
V
T
F
T
D
--
A
--
N
---
G
---
E
Q
K
E
T
-
F
D
K
L
I
V
A
V
G
R
R
P
V
T
T
D
L
L
A
A
D
S
G
V
T
L
D
E
R
G
F
I
Y
V
D
D
H
C
K
T
S
V
P
G
V
F
A
I
G
D
---
V
V
R
-
G
-
A
-
M
L
A
H
K
A
S
E
E
G
V
M
V
A
E
-
R
I
A
G
H
K
--
A
Q
-----
M
N
Y
D
L
----
I
P
S
V
I
Y
T
H
P
E
I
A
W
V
G
K
T
E
Q
T
L
K
A
E
G
-
V
-
E
--
V
N
V
G
-
T
F
P
F
A
A
S
G
R
A
M
A
A
N
D
T
T
G
L
V
K
V
I
A
D
A
K
T
D
R
V
L
G
V
H
V
I
G
P
S
-
A
A
E
L
V
Q
Q
G
A
I
G
M
E
F
G
T
S
A
E
D
L
G
M
M
V
F
S
H
P
---
T
L
S
E
--
A
L
H
E
A
A
L
A
V
N
G
H
A
I
H
I
--
77
PsiBlast_CBE
78.57
43%
-110
- C2 -
2YQU
6
?
B:
[3-455]
-----------
D
L
L
V
I
G
A
G
P
G
G
Y
V
A
A
I
R
A
A
Q
L
G
M
K
V
G
V
V
E
K
E------
K
------
A
-
L
G
G
T
C
L
R
V
G
C
I
P
S
K
A
L
L
-
E
T
T
E
-
R
I
Y
E
A
K
---
K
-
G
---
L
---
L
-
G
A
K
-
V
-
K
-
G
V
E
L
D
L
P
A
L
M
A
H
K
D
K
V
V
Q
A
N
T
Q
G
-
V
E
F
L
F
K
--
K
N
G
-
I
A
R
H
Q
G
T
A
R
F
L
S
---------
E
R
--
K
V
------
L
V
-
E
-----------
E
-------
T
G
-
E
-------
E
-----
L
E
A
R
Y
I
L
I
A
T
G
S
A
P
L
--
I
P
P
W
A
Q
--
V
---
D
Y
E
-
R
-----
V
--
V
-
T
S
T
E
A
L
S
F
P
-
E
-
V
--
P
K
R
L
I
V
V
G
G
G
V
I
G
L
E
L
G
V
V
W
H
R
L
G
A
E
V
I
V
L
E
Y
M
D
R
I
L
P
T
M
D
L
E
V
S
R
A
A
E
R
V
F
K
K
Q
-
G
--
L
T
I
R
T
G
V
R
V
T
A
V
V
P
E
-
A
K
G
--
A
R
V
---
E
--
L
--
E
---
G
---
G
E
-
V
L
E
A
D
R
V
L
V
A
V
G
R
R
P
Y
T
E
G
L
S
L
E
N
A
G
L
S
T
D
E
R
G
R
I
P
V
D
E
H
L
R
T
R
V
P
H
I
Y
A
I
G
D
---
V
V
R
-
G
-
P
-
M
L
A
H
K
A
S
E
E
G
I
A
A
V
E
-
H
M
V
R
G
F
--
G
H
-----
V
D
Y
Q
A
----
I
P
S
V
V
Y
T
H
P
E
I
A
A
V
G
Y
T
E
E
E
L
K
A
Q
G
-
I
-
P
--
Y
K
V
G
-
K
F
P
Y
S
A
S
G
R
A
R
A
M
G
E
T
E
G
F
I
K
V
L
A
H
A
K
T
D
R
I
L
G
V
H
G
I
G
A
R
-
V
G
D
V
L
A
E
A
A
L
A
L
F
F
K
A
S
A
E
D
L
G
R
A
P
H
A
H
P
---
S
L
S
E
--
I
L
K
E
A
A
L
A
A
W
E
R
P
I
H
L
--
2
PsiBlast_PDB
78.55
47%
-110
- C2 -
4JDR
9
DLDH_ECOLI
A:
[5-462]
-------
I
K
T
-
Q
V
V
V
L
G
A
G
P
A
G
Y
S
A
A
F
R
C
A
D
L
G
L
E
T
V
I
V
E
R
-------
Y
N-----
T
-
L
G
G
V
C
L
N
V
G
C
I
P
S
K
A
L
L
-
H
V
A
K
-
V
I
E
E
A
K
-
A
-
L
-
A
---
E
---
H
-
G
I
V
-
F
-
G
-
E
P
K
T
D
I
D
K
I
R
T
W
K
E
K
V
I
N
Q
L
T
G
G
-
L
A
G
M
A
K
--
G
R
K
-
V
K
V
V
N
G
L
G
K
F
T
G
---------
A
N
T
L
E
V
------
E
G
-
E
-----------
N
-------
G
K
-
T
-------
V
-----
I
N
F
D
N
A
I
I
A
A
G
S
R
P
I
--
Q
L
P
F
I
P
--
H
---
E
-
D
P
R
-----
I
--
W
-
D
S
T
D
A
L
E
L
K
-
E
-
V
--
P
E
R
L
L
V
M
G
G
G
I
I
G
L
E
M
G
T
V
Y
H
A
L
G
S
Q
I
D
V
V
E
M
F
D
Q
V
I
P
A
A
D
K
D
I
V
K
V
F
T
K
R
I
S
K
K
-
F
-
N
L
M
L
E
T
K
V
T
A
--
V
E
A
K
-
E
D
G
--
I
Y
V
T
M
-
E
--
G
--
K
KAP
A
---
E
P
Q
R
Y
D
A
--
V
L
V
A
I
G
R
V
P
N
G
K
N
L
D
A
G
K
A
G
V
E
V
D
D
R
G
F
I
R
V
D
K
Q
L
R
T
N
V
P
H
I
F
A
I
G
D
---
I
V
G
-
Q
-
P
-
M
L
A
H
K
G
V
H
E
G
H
V
A
A
E
-
V
I
A
G
K
K
--
H
Y
-----
F
D
P
K
V
----
I
P
S
I
A
Y
T
E
P
E
V
A
W
V
G
L
T
E
K
E
A
K
E
K
G
-
I
-
S
--
Y
E
T
A
-
T
F
P
W
A
A
S
G
R
A
I
A
S
D
C
A
D
G
M
T
K
L
I
F
D
K
E
S
H
R
V
I
G
G
A
I
V
G
T
N
-
G
G
E
L
L
G
E
I
G
L
A
I
E
M
G
C
D
A
E
D
I
A
L
T
I
H
A
H
P
---
T
L
H
E
--
S
V
G
L
A
A
E
V
F
E
G
S
------