@TOME V2.3
(Nov 2016)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : bsu16030: (2016-06-25 )
MKIDFLTLFPEMFEGVLGSSILQKAQEKDAVQFQVVNFREYSDNKHNTVDDYPYGGGAGMVLKPQPVFDAVEDLTSKAAAAPRIILVCPQGERFTQKKAEQLAKEEHLLFICGHYEGYDERIREHLVTDEISIGDFVLTGGELPAMMIADSVVRLLPGVLGKEASHIEDSFSTGLLEHPHYTRPADYKGLKVPETLLSGNHAKIEEWRNKESIRRTYLRRPDLLKDHPLTEQQRKWISEWEKE
Atome Classification :
(57 SA)
--.........10........20........30........40........50........60........70.....----..----.80........90........100.......110.......120....----...----130.......140.......150.......160.......170.-.--.....180.......190.......200.......210.......220..----.-...----.230.......240.-------
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
--MKI
D
F
L
T
L
F
P
E
M
F
E
G
V
L
G
S
S
I
L
Q
K
A
Q
EKD
A
V
Q
F
Q
V
V
N
F
R
EYSDNKHNTVDDYPYGGGAG
M
V
LKP
Q
P
V
F
D
A
V
E
D
L
T
S
----
K
A----AAA
P
R
I
I
L
VCPQGER
F
T
Q
K
K
A
E
Q
L
A
KEE
H
L
L
F
I
CGHYE
G
Y
D
E
R
I
R
E
H
L
----VTD----EISIG
D
F
V
LTGGEL
P
A
M
M
I
A
D
S
V
V
R
L
L
P
G
V
LGK
E
A
S
H
I
E
D
S
F
ST-G--LLEHPHYTRPADYKGLKV
P
E
T
L
LSGN
H
A
K
I
E
E
W
R
N
K
E
S
I
R
R
T
YLRRPDLL----K-DHP----L
T
E
Q
Q
R
K
W
I
S
E
WEKE-------
22
PsiBlast_CBE
78.17
46%
-144
- C9 -
4MCB
5
TRMD_HAEIN
B:
[1-243]
--
M
W
I
G
V
I
S
L
F
P
E
M
F
K
A
I
T
E
F
G
V
T
G
R
A
V
K
H
N
L
L
K
V
E
C
W
N
P
R
D
F
T
F
D
K
H
K
T
V
D
D
R
P
Y
G
G
G
P
G
M
L
M
M
V
Q
P
L
R
D
A
I
H
T
A
K
A
----
A
A
----
G
E
G
A
K
V
I
Y
L
S
P
Q
G
R
K
L
D
Q
G
G
V
T
E
L
A
Q
N
Q
K
L
I
L
V
C
G
R
Y
E
G
I
D
E
R
L
I
Q
T
E
----
I
D
E
----
E
W
S
I
G
D
Y
V
L
T
G
G
E
L
P
A
M
T
L
I
D
A
V
A
R
F
I
P
G
V
L
G
K
Q
A
S
A
E
E
D
S
F
A
D
-
G
--
L
L
D
C
P
H
Y
T
R
P
E
V
L
E
G
L
T
V
P
P
V
L
M
S
G
H
H
E
E
I
R
K
W
R
L
K
Q
S
L
Q
R
T
W
L
R
R
P
E
L
L
----
E
-
G
L
A
----
L
T
D
E
Q
R
K
L
L
K
E
A
Q
A
E
-------
23
PsiBlast_CBE
76.75
46%
-142
- C9 -
4YVK
2
TRMD_HAEIN
B:
[21-263]
--
M
W
I
G
V
I
S
L
F
P
E
M
F
K
A
I
T
E
F
G
V
T
G
R
A
V
K
H
N
L
L
K
V
E
C
W
N
P
R
D
F
T
F
D
K
H
K
T
V
D
D
R
P
Y
G
G
G
P
G
M
L
M
M
V
Q
P
L
R
D
A
I
H
T
A
K
A
----
A
A
----
G
E
G
A
K
V
I
Y
L
S
P
Q
G
R
K
L
D
Q
G
G
V
T
E
L
A
Q
N
Q
K
L
I
L
V
C
G
R
Y
E
G
I
D
E
R
L
I
Q
T
E
----
I
D
E
----
E
W
S
I
G
D
Y
V
L
T
G
G
E
L
P
A
M
T
L
I
D
A
V
A
R
F
I
P
G
V
L
G
K
Q
A
S
A
E
E
D
S
F
A
D
-
G
--
L
L
D
C
P
H
Y
T
R
P
E
V
L
E
G
L
T
V
P
P
V
L
M
S
G
H
H
E
E
I
R
K
W
R
L
K
Q
S
L
Q
R
T
W
L
R
R
P
E
L
L
----
E
-
G
L
A
----
L
T
D
E
Q
R
K
L
L
K
E
A
Q
A
E
-------
44
PsiBlast_CBE
76.49
46%
-146
- C9 -
4YQ4
2
?
A:
[9-251]
--
M
W
I
G
V
I
S
L
F
P
E
M
F
K
A
I
T
E
F
G
V
T
G
R
A
V
K
H
N
L
L
K
V
E
C
W
N
P
R
D
F
T
F
D
K
H
K
T
V
D
D
R
P
Y
G
G
G
P
G
M
L
M
M
V
Q
P
L
R
D
A
I
H
T
A
K
A
----
A
A
----
G
E
G
A
K
V
I
Y
L
S
P
Q
G
R
K
L
D
Q
G
G
V
T
E
L
A
Q
N
Q
K
L
I
L
V
C
G
R
Y
E
G
I
D
E
R
L
I
Q
T
E
----
I
D
E
----
E
W
S
I
G
D
Y
V
L
T
G
G
E
L
P
A
M
T
L
I
D
A
V
A
R
F
I
P
G
V
L
G
-------
D
S
F
A
D
-
G
--
L
L
D
C
P
H
Y
T
R
P
E
V
L
E
G
L
T
V
P
P
V
L
M
S
G
H
H
E
E
I
R
K
W
R
L
K
Q
S
L
Q
R
T
W
L
R
R
P
E
L
L
----
E
-
G
L
A
----
L
T
D
E
Q
R
K
L
L
K
E
A
Q
A
E
-------
25
PsiBlast_CBE
76.39
46%
-142
- C9 -
4YVI
2
TRMD_HAEIN
B:
[21-263]
--
M
W
I
G
V
I
S
L
F
P
E
M
F
K
A
I
T
E
F
G
V
T
G
R
A
V
K
H
N
L
L
K
V
E
C
W
N
P
R
D
F
T
F
D
K
H
K
T
V
D
D
R
P
Y
G
G
G
P
G
M
L
M
M
V
Q
P
L
R
D
A
I
H
T
A
K
A
----
A
A
----
G
E
G
A
K
V
I
Y
L
S
P
Q
G
R
K
L
D
Q
G
G
V
T
E
L
A
Q
N
Q
K
L
I
L
V
C
G
R
Y
E
G
I
D
E
R
L
I
Q
T
E
----
I
D
E
----
E
W
S
I
G
D
Y
V
L
T
G
G
E
L
P
A
M
T
L
I
D
A
V
A
R
F
I
P
G
V
L
G
K
Q
A
S
A
E
E
D
S
F
A
D
-
G
--
L
L
D
C
P
H
Y
T
R
P
E
V
L
E
G
L
T
V
P
P
V
L
M
S
G
H
H
E
E
I
R
K
W
R
L
K
Q
S
L
Q
R
T
W
L
R
R
P
E
L
L
----
E
-
G
L
A
----
L
T
D
E
Q
R
K
L
L
K
E
A
Q
A
E
-------
24
PsiBlast_CBE
76.36
46%
-141
- C9 -
4YVJ
2
TRMD_HAEIN
B:
[21-263]
--
M
W
I
G
V
I
S
L
F
P
E
M
F
K
A
I
T
E
F
G
V
T
G
R
A
V
K
H
N
L
L
K
V
E
C
W
N
P
R
D
F
T
F
D
K
H
K
T
V
D
D
R
P
Y
G
G
G
P
G
M
L
M
M
V
Q
P
L
R
D
A
I
H
T
A
K
A
----
A
A
----
G
E
G
A
K
V
I
Y
L
S
P
Q
G
R
K
L
D
Q
G
G
V
T
E
L
A
Q
N
Q
K
L
I
L
V
C
G
R
Y
E
G
I
D
E
R
L
I
Q
T
E
----
I
D
E
----
E
W
S
I
G
D
Y
V
L
T
G
G
E
L
P
A
M
T
L
I
D
A
V
A
R
F
I
P
G
V
L
G
K
Q
A
S
A
E
E
D
S
F
A
D
-
G
--
L
L
D
C
P
H
Y
T
R
P
E
V
L
E
G
L
T
V
P
P
V
L
M
S
G
H
H
E
E
I
R
K
W
R
L
K
Q
S
L
Q
R
T
W
L
R
R
P
E
L
L
----
E
-
G
L
A
----
L
T
D
E
Q
R
K
L
L
K
E
A
Q
A
E
-------
9
PsiBlast_PDB
76.23
46%
-150
- C9 -
4YVG
1
TRMD_HAEIN
A:
[21-263]
--
M
W
I
G
V
I
S
L
F
P
E
M
F
K
A
I
T
E
F
G
V
T
G
R
A
V
K
H
N
L
L
K
V
E
C
W
N
P
R
D
F
T
F
D
K
H
K
T
V
D
D
R
P
Y
G
G
G
P
G
M
L
M
M
V
Q
P
L
R
D
A
I
H
T
A
K
A
----
A
A
----
G
E
G
A
K
V
I
Y
L
S
P
Q
G
R
K
L
D
Q
G
G
V
T
E
L
A
Q
N
Q
K
L
I
L
V
C
G
R
Y
E
G
I
D
E
R
L
I
Q
T
E
----
I
D
E
----
E
W
S
I
G
D
Y
V
L
T
G
G
E
L
P
A
M
T
L
I
D
A
V
A
R
F
I
P
G
V
L
--------
D
S
F
A
D
-
G
--
L
L
D
C
P
H
Y
T
R
P
E
V
L
E
G
L
T
V
P
P
V
L
M
S
G
H
H
E
E
I
R
K
W
R
L
K
Q
S
L
Q
R
T
W
L
R
R
P
E
L
L
----
E
-
G
L
A
----
L
T
D
E
Q
R
K
L
L
K
E
A
Q
A
E
-------
45
PsiBlast_CBE
76.22
46%
-149
- C9 -
4YQ3
1
?
A:
[9-251]
--
M
W
I
G
V
I
S
L
F
P
E
M
F
K
A
I
T
E
F
G
V
T
G
R
A
V
K
H
N
L
L
K
V
E
C
W
N
P
R
D
F
T
F
D
K
H
K
T
V
D
D
R
P
Y
G
G
G
P
G
M
L
M
M
V
Q
P
L
R
D
A
I
H
T
A
K
A
----
A
A
----
G
E
G
A
K
V
I
Y
L
S
P
Q
G
R
K
L
D
Q
G
G
V
T
E
L
A
Q
N
Q
K
L
I
L
V
C
G
R
Y
E
G
I
D
E
R
L
I
Q
T
E
----
I
D
E
----
E
W
S
I
G
D
Y
V
L
T
G
G
E
L
P
A
M
T
L
I
D
A
V
A
R
F
I
P
G
V
L
G
-----------
D
-
G
--
L
L
D
C
P
H
Y
T
R
P
E
V
L
E
G
L
T
V
P
P
V
L
M
S
G
H
H
E
E
I
R
K
W
R
L
K
Q
S
L
Q
R
T
W
L
R
R
P
E
L
L
----
E
-
G
L
A
----
L
T
D
E
Q
R
K
L
L
K
E
A
Q
A
E
-------
35
PsiBlast_CBE
76.04
46%
-154
- C9 -
4YQI
1
?
A:
[9-251]
--
M
W
I
G
V
I
S
L
F
P
E
M
F
K
A
I
T
E
F
G
V
T
G
R
A
V
K
H
N
L
L
K
V
E
C
W
N
P
R
D
F
T
F
D
K
H
K
T
V
D
D
R
P
Y
G
G
G
P
G
M
L
M
M
V
Q
P
L
R
D
A
I
H
T
A
K
A
----
A
A
----
G
E
G
A
K
V
I
Y
L
S
P
Q
G
R
K
L
D
Q
G
G
V
T
E
L
A
Q
N
Q
K
L
I
L
V
C
G
R
Y
E
G
I
D
E
R
L
I
Q
T
E
----
I
D
E
----
E
W
S
I
G
D
Y
V
L
T
G
G
E
L
P
A
M
T
L
I
D
A
V
A
R
F
I
P
G
V
L
G
-----------
D
-
G
--
L
L
D
C
P
H
Y
T
R
P
E
V
L
E
G
L
T
V
P
P
V
L
M
S
G
H
H
E
E
I
R
K
W
R
L
K
Q
S
L
Q
R
T
W
L
R
R
P
E
L
L
----
E
-
G
L
A
----
L
T
D
E
Q
R
K
L
L
K
E
A
Q
A
E
-------
33
PsiBlast_CBE
76.04
46%
-155
- C9 -
4YQK
1
?
A:
[9-251]
--
M
W
I
G
V
I
S
L
F
P
E
M
F
K
A
I
T
E
F
G
V
T
G
R
A
V
K
H
N
L
L
K
V
E
C
W
N
P
R
D
F
T
F
D
K
H
K
T
V
D
D
R
P
Y
G
G
G
P
G
M
L
M
M
V
Q
P
L
R
D
A
I
H
T
A
K
A
----
A
A
----
G
E
G
A
K
V
I
Y
L
S
P
Q
G
R
K
L
D
Q
G
G
V
T
E
L
A
Q
N
Q
K
L
I
L
V
C
G
R
Y
E
G
I
D
E
R
L
I
Q
T
E
----
I
D
E
----
E
W
S
I
G
D
Y
V
L
T
G
G
E
L
P
A
M
T
L
I
D
A
V
A
R
F
I
P
G
V
L
G
-----------
D
-
G
--
L
L
D
C
P
H
Y
T
R
P
E
V
L
E
G
L
T
V
P
P
V
L
M
S
G
H
H
E
E
I
R
K
W
R
L
K
Q
S
L
Q
R
T
W
L
R
R
P
E
L
L
----
E
-
G
L
A
----
L
T
D
E
Q
R
K
L
L
K
E
A
Q
A
E
-------
4
PsiBlast_PDB
76.03
46%
-139
- C9 -
1UAM
2
TRMD_HAEIN
A:
[21-263]
--
M
W
I
G
V
I
S
L
F
P
E
M
F
K
A
I
T
E
F
G
V
T
G
R
A
V
K
H
N
L
L
K
V
E
C
W
N
P
R
D
F
T
F
D
K
H
K
T
V
D
D
R
P
Y
G
G
G
P
G
M
L
M
M
V
Q
P
L
R
D
A
I
H
T
A
K
A
----
A
A
----
G
E
G
A
K
V
I
Y
L
S
P
Q
G
R
K
L
D
Q
G
G
V
T
E
L
A
Q
N
Q
K
L
I
L
V
C
G
R
Y
E
G
I
D
E
R
L
I
Q
T
E
----
I
D
E
----
E
W
S
I
G
D
Y
V
L
T
G
G
E
L
P
A
M
T
L
I
D
A
V
A
R
F
I
P
G
V
L
G
K
Q
A
--
E
E
D
S
F
A
D
-
G
--
L
L
D
C
P
H
Y
T
R
P
E
V
L
E
G
L
T
V
P
P
V
L
M
S
G
H
H
E
E
I
R
K
W
R
L
K
Q
S
L
Q
R
T
W
L
R
R
P
E
L
L
----
E
-
G
L
A
----
L
T
D
E
Q
R
K
L
L
K
E
A
Q
A
E
-------
11
PsiBlast_PDB
75.97
46%
-149
- C9 -
4YVI
2
TRMD_HAEIN
A:
[21-263]
--
M
W
I
G
V
I
S
L
F
P
E
M
F
K
A
I
T
E
F
G
V
T
G
R
A
V
K
H
N
L
L
K
V
E
C
W
N
P
R
D
F
T
F
D
K
H
K
T
V
D
D
R
P
Y
G
G
G
P
G
M
L
M
M
V
Q
P
L
R
D
A
I
H
T
A
K
A
----
A
A
----
G
E
G
A
K
V
I
Y
L
S
P
Q
G
R
K
L
D
Q
G
G
V
T
E
L
A
Q
N
Q
K
L
I
L
V
C
G
R
Y
E
G
I
D
E
R
L
I
Q
T
E
----
I
D
E
----
E
W
S
I
G
D
Y
V
L
T
G
G
E
L
P
A
M
T
L
I
D
A
V
A
R
F
I
P
G
V
L
--------
D
S
F
A
D
-
G
--
L
L
D
C
P
H
Y
T
R
P
E
V
L
E
G
L
T
V
P
P
V
L
M
S
G
H
H
E
E
I
R
K
W
R
L
K
Q
S
L
Q
R
T
W
L
R
R
P
E
L
L
----
E
-
G
L
A
----
L
T
D
E
Q
R
K
L
L
K
E
A
Q
A
E
-------
29
PsiBlast_CBE
75.77
46%
-153
- C9 -
4YQP
1
?
A:
[9-251]
--
M
W
I
G
V
I
S
L
F
P
E
M
F
K
A
I
T
E
F
G
V
T
G
R
A
V
K
H
N
L
L
K
V
E
C
W
N
P
R
D
F
T
F
D
K
H
K
T
V
D
D
R
P
Y
G
G
G
P
G
M
L
M
M
V
Q
P
L
R
D
A
I
H
T
A
K
A
----
A
A
----
G
E
G
A
K
V
I
Y
L
S
P
Q
G
R
K
L
D
Q
G
G
V
T
E
L
A
Q
N
Q
K
L
I
L
V
C
G
R
Y
E
G
I
D
E
R
L
I
Q
T
E
----
I
D
E
----
E
W
S
I
G
D
Y
V
L
T
G
G
E
L
P
A
M
T
L
I
D
A
V
A
R
F
I
P
G
V
L
G
-----------
D
-
G
--
L
L
D
C
P
H
Y
T
R
P
E
V
L
E
G
L
T
V
P
P
V
L
M
S
G
H
H
E
E
I
R
K
W
R
L
K
Q
S
L
Q
R
T
W
L
R
R
P
E
L
L
----
E
-
G
L
A
----
L
T
D
E
Q
R
K
L
L
K
E
A
Q
A
E
-------
34
PsiBlast_CBE
75.76
46%
-157
- C9 -
4YQJ
1
?
A:
[9-251]
--
M
W
I
G
V
I
S
L
F
P
E
M
F
K
A
I
T
E
F
G
V
T
G
R
A
V
K
H
N
L
L
K
V
E
C
W
N
P
R
D
F
T
F
D
K
H
K
T
V
D
D
R
P
Y
G
G
G
P
G
M
L
M
M
V
Q
P
L
R
D
A
I
H
T
A
K
A
----
A
A
----
G
E
G
A
K
V
I
Y
L
S
P
Q
G
R
K
L
D
Q
G
G
V
T
E
L
A
Q
N
Q
K
L
I
L
V
C
G
R
Y
E
G
I
D
E
R
L
I
Q
T
E
----
I
D
E
----
E
W
S
I
G
D
Y
V
L
T
G
G
E
L
P
A
M
T
L
I
D
A
V
A
R
F
I
P
G
V
L
G
-----------
D
-
G
--
L
L
D
C
P
H
Y
T
R
P
E
V
L
E
G
L
T
V
P
P
V
L
M
S
G
H
H
E
E
I
R
K
W
R
L
K
Q
S
L
Q
R
T
W
L
R
R
P
E
L
L
----
E
-
G
L
A
----
L
T
D
E
Q
R
K
L
L
K
E
A
Q
A
E
-------
15
PsiBlast_PDB
75.66
46%
-157
- C9 -
4YPW
1
?
A:
[9-251]
--
M
W
I
G
V
I
S
L
F
P
E
M
F
K
A
I
T
E
F
G
V
T
G
R
A
V
K
H
N
L
L
K
V
E
C
W
N
P
R
D
F
T
F
D
K
H
K
T
V
D
D
R
P
Y
G
G
G
P
G
M
L
M
M
V
Q
P
L
R
D
A
I
H
T
A
K
A
----
A
A
----
G
E
G
A
K
V
I
Y
L
S
P
Q
G
R
K
L
D
Q
G
G
V
T
E
L
A
Q
N
Q
K
L
I
L
V
C
G
R
Y
E
G
I
D
E
R
L
I
Q
T
E
----
I
D
E
----
E
W
S
I
G
D
Y
V
L
T
G
G
E
L
P
A
M
T
L
I
D
A
V
A
R
F
I
P
G
V
L
G
-----------
D
-
G
--
L
L
D
C
P
H
Y
T
R
P
E
V
L
E
G
L
T
V
P
P
V
L
M
S
G
H
H
E
E
I
R
K
W
R
L
K
Q
S
L
Q
R
T
W
L
R
R
P
E
L
L
----
E
-
G
L
A
----
L
T
D
E
Q
R
K
L
L
K
E
A
Q
A
E
-------
27
PsiBlast_CBE
75.64
46%
-153
- C9 -
4YQS
1
?
A:
[9-251]
--
M
W
I
G
V
I
S
L
F
P
E
M
F
K
A
I
T
E
F
G
V
T
G
R
A
V
K
H
N
L
L
K
V
E
C
W
N
P
R
D
F
T
F
D
K
H
K
T
V
D
D
R
P
Y
G
G
G
P
G
M
L
M
M
V
Q
P
L
R
D
A
I
H
T
A
K
A
----
A
A
----
G
E
G
A
K
V
I
Y
L
S
P
Q
G
R
K
L
D
Q
G
G
V
T
E
L
A
Q
N
Q
K
L
I
L
V
C
G
R
Y
E
G
I
D
E
R
L
I
Q
T
E
----
I
D
E
----
E
W
S
I
G
D
Y
V
L
T
G
G
E
L
P
A
M
T
L
I
D
A
V
A
R
F
I
P
G
V
L
G
-----------
D
-
G
--
L
L
D
C
P
H
Y
T
R
P
E
V
L
E
G
L
T
V
P
P
V
L
M
S
G
H
H
E
E
I
R
K
W
R
L
K
Q
S
L
Q
R
T
W
L
R
R
P
E
L
L
----
E
-
G
L
A
----
L
T
D
E
Q
R
K
L
L
K
E
A
Q
A
E
-------
19
PsiBlast_PDB
75.61
46%
-157
- C9 -
4YQ0
1
?
A:
[9-251]
--
M
W
I
G
V
I
S
L
F
P
E
M
F
K
A
I
T
E
F
G
V
T
G
R
A
V
K
H
N
L
L
K
V
E
C
W
N
P
R
D
F
T
F
D
K
H
K
T
V
D
D
R
P
Y
G
G
G
P
G
M
L
M
M
V
Q
P
L
R
D
A
I
H
T
A
K
A
----
A
A
----
G
E
G
A
K
V
I
Y
L
S
P
Q
G
R
K
L
D
Q
G
G
V
T
E
L
A
Q
N
Q
K
L
I
L
V
C
G
R
Y
E
G
I
D
E
R
L
I
Q
T
E
----
I
D
E
----
E
W
S
I
G
D
Y
V
L
T
G
G
E
L
P
A
M
T
L
I
D
A
V
A
R
F
I
P
G
V
L
G
-----------
D
-
G
--
L
L
D
C
P
H
Y
T
R
P
E
V
L
E
G
L
T
V
P
P
V
L
M
S
G
H
H
E
E
I
R
K
W
R
L
K
Q
S
L
Q
R
T
W
L
R
R
P
E
L
L
----
E
-
G
L
A
----
L
T
D
E
Q
R
K
L
L
K
E
A
Q
A
E
-------
40
PsiBlast_CBE
75.57
46%
-148
- C9 -
4YQ9
1
?
A:
[9-251]
--
M
W
I
G
V
I
S
L
F
P
E
M
F
K
A
I
T
E
F
G
V
T
G
R
A
V
K
H
N
L
L
K
V
E
C
W
N
P
R
D
F
T
F
D
K
H
K
T
V
D
D
R
P
Y
G
G
G
P
G
M
L
M
M
V
Q
P
L
R
D
A
I
H
T
A
K
A
----
A
A
----
G
E
G
A
K
V
I
Y
L
S
P
Q
G
R
K
L
D
Q
G
G
V
T
E
L
A
Q
N
Q
K
L
I
L
V
C
G
R
Y
E
G
I
D
E
R
L
I
Q
T
E
----
I
D
E
----
E
W
S
I
G
D
Y
V
L
T
G
G
E
L
P
A
M
T
L
I
D
A
V
A
R
F
I
P
G
V
L
G
--------
S
F
A
D
-
G
--
L
L
D
C
P
H
Y
T
R
P
E
V
L
E
G
L
T
V
P
P
V
L
M
S
G
H
H
E
E
I
R
K
W
R
L
K
Q
S
L
Q
R
T
W
L
R
R
P
E
L
L
----
E
-
G
L
A
----
L
T
D
E
Q
R
K
L
L
K
E
A
Q
A
E
-------
38
PsiBlast_CBE
75.56
46%
-148
- C9 -
4YQB
1
?
A:
[9-251]
--
M
W
I
G
V
I
S
L
F
P
E
M
F
K
A
I
T
E
F
G
V
T
G
R
A
V
K
H
N
L
L
K
V
E
C
W
N
P
R
D
F
T
F
D
K
H
K
T
V
D
D
R
P
Y
G
G
G
P
G
M
L
M
M
V
Q
P
L
R
D
A
I
H
T
A
K
A
----
A
A
----
G
E
G
A
K
V
I
Y
L
S
P
Q
G
R
K
L
D
Q
G
G
V
T
E
L
A
Q
N
Q
K
L
I
L
V
C
G
R
Y
E
G
I
D
E
R
L
I
Q
T
E
----
I
D
E
----
E
W
S
I
G
D
Y
V
L
T
G
G
E
L
P
A
M
T
L
I
D
A
V
A
R
F
I
P
G
V
L
G
--------
S
F
A
D
-
G
--
L
L
D
C
P
H
Y
T
R
P
E
V
L
E
G
L
T
V
P
P
V
L
M
S
G
H
H
E
E
I
R
K
W
R
L
K
Q
S
L
Q
R
T
W
L
R
R
P
E
L
L
----
E
-
G
L
A
----
L
T
D
E
Q
R
K
L
L
K
E
A
Q
A
E
-------
42
PsiBlast_CBE
75.54
46%
-151
- C9 -
4YQ6
1
?
A:
[9-251]
--
M
W
I
G
V
I
S
L
F
P
E
M
F
K
A
I
T
E
F
G
V
T
G
R
A
V
K
H
N
L
L
K
V
E
C
W
N
P
R
D
F
T
F
D
K
H
K
T
V
D
D
R
P
Y
G
G
G
P
G
M
L
M
M
V
Q
P
L
R
D
A
I
H
T
A
K
A
----
A
A
----
G
E
G
A
K
V
I
Y
L
S
P
Q
G
R
K
L
D
Q
G
G
V
T
E
L
A
Q
N
Q
K
L
I
L
V
C
G
R
Y
E
G
I
D
E
R
L
I
Q
T
E
----
I
D
E
----
E
W
S
I
G
D
Y
V
L
T
G
G
E
L
P
A
M
T
L
I
D
A
V
A
R
F
I
P
G
V
L
G
-----------
D
-
G
--
L
L
D
C
P
H
Y
T
R
P
E
V
L
E
G
L
T
V
P
P
V
L
M
S
G
H
H
E
E
I
R
K
W
R
L
K
Q
S
L
Q
R
T
W
L
R
R
P
E
L
L
----
E
-
G
L
A
----
L
T
D
E
Q
R
K
L
L
K
E
A
Q
A
E
-------
30
PsiBlast_CBE
75.51
46%
-152
- C9 -
4YQO
1
?
A:
[9-251]
--
M
W
I
G
V
I
S
L
F
P
E
M
F
K
A
I
T
E
F
G
V
T
G
R
A
V
K
H
N
L
L
K
V
E
C
W
N
P
R
D
F
T
F
D
K
H
K
T
V
D
D
R
P
Y
G
G
G
P
G
M
L
M
M
V
Q
P
L
R
D
A
I
H
T
A
K
A
----
A
A
----
G
E
G
A
K
V
I
Y
L
S
P
Q
G
R
K
L
D
Q
G
G
V
T
E
L
A
Q
N
Q
K
L
I
L
V
C
G
R
Y
E
G
I
D
E
R
L
I
Q
T
E
----
I
D
E
----
E
W
S
I
G
D
Y
V
L
T
G
G
E
L
P
A
M
T
L
I
D
A
V
A
R
F
I
P
G
V
L
------------
D
-
G
--
L
L
D
C
P
H
Y
T
R
P
E
V
L
E
G
L
T
V
P
P
V
L
M
S
G
H
H
E
E
I
R
K
W
R
L
K
Q
S
L
Q
R
T
W
L
R
R
P
E
L
L
----
E
-
G
L
A
----
L
T
D
E
Q
R
K
L
L
K
E
A
Q
A
E
-------
1
PsiBlast_PDB
75.51
46%
-154
- C9 -
1UAJ
-
TRMD_HAEIN
A:
[1-243]
--
M
W
I
G
V
I
S
L
F
P
E
M
F
K
A
I
T
E
F
G
V
T
G
R
A
V
K
H
N
L
L
K
V
E
C
W
N
P
R
D
F
T
F
D
K
H
K
T
V
D
D
R
P
Y
G
G
G
P
G
M
L
M
M
V
Q
P
L
R
D
A
I
H
T
A
K
A
----
A
A
----
G
E
G
A
K
V
I
Y
L
S
P
Q
G
R
K
L
D
Q
G
G
V
T
E
L
A
Q
N
Q
K
L
I
L
V
C
G
R
Y
E
G
I
D
E
R
L
I
Q
T
E
----
I
D
E
----
E
W
S
I
G
D
Y
V
L
T
G
G
E
L
P
A
M
T
L
I
D
A
V
A
R
F
I
P
G
V
L
G
----------------
L
L
D
C
P
H
Y
T
R
P
E
V
L
E
G
L
T
V
P
P
V
L
M
S
G
H
H
E
E
I
R
K
W
R
L
K
Q
S
L
Q
R
T
W
L
R
R
P
E
L
L
----
E
-
G
L
A
----
L
T
D
E
Q
R
K
L
L
K
E
A
Q
A
E
-------
47
PsiBlast_CBE
75.43
46%
-152
- C9 -
1P9P
1
TRMD_ECOLI
A:
[7-249]
--
M
W
I
G
I
I
S
L
F
P
E
M
F
R
A
I
T
D
Y
G
V
T
G
R
A
V
K
N
G
L
L
S
I
Q
S
W
S
P
R
D
F
T
H
D
R
H
R
T
V
D
D
R
P
Y
G
G
G
P
G
M
L
M
M
V
Q
P
L
R
D
A
I
H
A
A
K
A
----
A
A
----
G
E
G
A
K
V
I
Y
L
S
P
Q
G
R
K
L
D
Q
A
G
V
S
E
L
A
T
N
Q
K
L
I
L
V
C
G
R
Y
E
G
I
D
E
R
V
I
Q
T
E
----
I
D
E
----
E
W
S
I
G
D
Y
V
L
S
G
G
E
L
P
A
M
T
L
I
D
S
V
S
R
F
I
P
G
V
L
G
-----------
E
-
G
--
L
L
D
C
P
H
Y
T
R
P
E
V
L
E
G
M
E
V
P
P
V
L
L
S
G
N
H
A
E
I
R
R
W
R
L
K
Q
S
L
G
R
T
W
L
R
R
P
E
L
L
----
E
-
N
L
A
----
L
T
E
E
Q
A
R
L
L
A
E
F
K
T
E
-------
31
PsiBlast_CBE
75.43
46%
-155
- C9 -
4YQN
1
?
A:
[9-251]
--
M
W
I
G
V
I
S
L
F
P
E
M
F
K
A
I
T
E
F
G
V
T
G
R
A
V
K
H
N
L
L
K
V
E
C
W
N
P
R
D
F
T
F
D
K
H
K
T
V
D
D
R
P
Y
G
G
G
P
G
M
L
M
M
V
Q
P
L
R
D
A
I
H
T
A
K
A
----
A
A
----
G
E
G
A
K
V
I
Y
L
S
P
Q
G
R
K
L
D
Q
G
G
V
T
E
L
A
Q
N
Q
K
L
I
L
V
C
G
R
Y
E
G
I
D
E
R
L
I
Q
T
E
----
I
D
E
----
E
W
S
I
G
D
Y
V
L
T
G
G
E
L
P
A
M
T
L
I
D
A
V
A
R
F
I
P
G
V
L
G
-----------
D
-
G
--
L
L
D
C
P
H
Y
T
R
P
E
V
L
E
G
L
T
V
P
P
V
L
M
S
G
H
H
E
E
I
R
K
W
R
L
K
Q
S
L
Q
R
T
W
L
R
R
P
E
L
L
----
E
-
G
L
A
----
L
T
D
E
Q
R
K
L
L
K
E
A
Q
A
E
-------
10
PsiBlast_PDB
75.43
46%
-149
- C9 -
4YVH
1
TRMD_HAEIN
A:
[21-263]
--
M
W
I
G
V
I
S
L
F
P
E
M
F
K
A
I
T
E
F
G
V
T
G
R
A
V
K
H
N
L
L
K
V
E
C
W
N
P
R
D
F
T
F
D
K
H
K
T
V
D
D
R
P
Y
G
G
G
P
G
M
L
M
M
V
Q
P
L
R
D
A
I
H
T
A
K
A
----
A
A
----
G
E
G
A
K
V
I
Y
L
S
P
Q
G
R
K
L
D
Q
G
G
V
T
E
L
A
Q
N
Q
K
L
I
L
V
C
G
R
Y
E
G
I
D
E
R
L
I
Q
T
E
----
I
D
E
----
E
W
S
I
G
D
Y
V
L
T
G
G
E
L
P
A
M
T
L
I
D
A
V
A
R
F
I
P
G
V
L
--------
D
S
F
A
D
-
G
--
L
L
D
C
P
H
Y
T
R
P
E
V
L
E
G
L
T
V
P
P
V
L
M
S
G
H
H
E
E
I
R
K
W
R
L
K
Q
S
L
Q
R
T
W
L
R
R
P
E
L
L
----
E
-
G
L
A
----
L
T
D
E
Q
R
K
L
L
K
E
A
Q
A
E
-------
41
PsiBlast_CBE
75.28
46%
-150
- C9 -
4YQ7
1
?
A:
[9-251]
--
M
W
I
G
V
I
S
L
F
P
E
M
F
K
A
I
T
E
F
G
V
T
G
R
A
V
K
H
N
L
L
K
V
E
C
W
N
P
R
D
F
T
F
D
K
H
K
T
V
D
D
R
P
Y
G
G
G
P
G
M
L
M
M
V
Q
P
L
R
D
A
I
H
T
A
K
A
----
A
A
----
G
E
G
A
K
V
I
Y
L
S
P
Q
G
R
K
L
D
Q
G
G
V
T
E
L
A
Q
N
Q
K
L
I
L
V
C
G
R
Y
E
G
I
D
E
R
L
I
Q
T
E
----
I
D
E
----
E
W
S
I
G
D
Y
V
L
T
G
G
E
L
P
A
M
T
L
I
D
A
V
A
R
F
I
P
G
V
L
G
-----------
D
-
G
--
L
L
D
C
P
H
Y
T
R
P
E
V
L
E
G
L
T
V
P
P
V
L
M
S
G
H
H
E
E
I
R
K
W
R
L
K
Q
S
L
Q
R
T
W
L
R
R
P
E
L
L
----
E
-
G
L
A
----
L
T
D
E
Q
R
K
L
L
K
E
A
Q
A
E
-------
39
PsiBlast_CBE
75.23
46%
-151
- C9 -
4YQA
1
?
A:
[9-251]
--
M
W
I
G
V
I
S
L
F
P
E
M
F
K
A
I
T
E
F
G
V
T
G
R
A
V
K
H
N
L
L
K
V
E
C
W
N
P
R
D
F
T
F
D
K
H
K
T
V
D
D
R
P
Y
G
G
G
P
G
M
L
M
M
V
Q
P
L
R
D
A
I
H
T
A
K
A
----
A
A
----
G
E
G
A
K
V
I
Y
L
S
P
Q
G
R
K
L
D
Q
G
G
V
T
E
L
A
Q
N
Q
K
L
I
L
V
C
G
R
Y
E
G
I
D
E
R
L
I
Q
T
E
----
I
D
E
----
E
W
S
I
G
D
Y
V
L
T
G
G
E
L
P
A
M
T
L
I
D
A
V
A
R
F
I
P
G
V
L
G
-----------
D
-
G
--
L
L
D
C
P
H
Y
T
R
P
E
V
L
E
G
L
T
V
P
P
V
L
M
S
G
H
H
E
E
I
R
K
W
R
L
K
Q
S
L
Q
R
T
W
L
R
R
P
E
L
L
----
E
-
G
L
A
----
L
T
D
E
Q
R
K
L
L
K
E
A
Q
A
E
-------
32
PsiBlast_CBE
75.20
46%
-151
- C9 -
4YQL
1
?
A:
[9-251]
--
M
W
I
G
V
I
S
L
F
P
E
M
F
K
A
I
T
E
F
G
V
T
G
R
A
V
K
H
N
L
L
K
V
E
C
W
N
P
R
D
F
T
F
D
K
H
K
T
V
D
D
R
P
Y
G
G
G
P
G
M
L
M
M
V
Q
P
L
R
D
A
I
H
T
A
K
A
----
A
A
----
G
E
G
A
K
V
I
Y
L
S
P
Q
G
R
K
L
D
Q
G
G
V
T
E
L
A
Q
N
Q
K
L
I
L
V
C
G
R
Y
E
G
I
D
E
R
L
I
Q
T
E
----
I
D
E
----
E
W
S
I
G
D
Y
V
L
T
G
G
E
L
P
A
M
T
L
I
D
A
V
A
R
F
I
P
G
V
L
G
--------
S
F
A
D
-
G
--
L
L
D
C
P
H
Y
T
R
P
E
V
L
E
G
L
T
V
P
P
V
L
M
S
G
H
H
E
E
I
R
K
W
R
L
K
Q
S
L
Q
R
T
W
L
R
R
P
E
L
L
----
E
-
G
L
A
----
L
T
D
E
Q
R
K
L
L
K
E
A
Q
A
E
-------
55
Fugue
75.19
44%
-154
- C9 -
1UAL
1
TRMD_HAEIN
A:
[19-270]
SH
M
W
I
G
V
I
S
L
F
P
E
M
F
K
A
I
T
E
F
G
V
T
G
R
A
V
K
H
N
L
L
K
V
E
C
W
N
P
R
D
F
T
F
D
K
H
K
T
V
D
D
R
P
Y
G
G
G
P
G
M
L
M
M
V
Q
P
L
R
D
A
I
H
T
A
K
A
----
A
A
----
G
E
G
A
K
V
I
Y
L
S
P
Q
G
R
K
L
D
Q
G
G
V
T
E
L
A
Q
N
Q
K
L
I
L
V
C
G
R
Y
E
G
I
D
E
R
L
I
Q
T
E
----
I
D
E
----
E
W
S
I
G
D
Y
V
L
T
G
G
E
L
P
A
M
T
L
I
D
A
V
A
R
F
I
P
G
V
L
S
---------
F
A
D
-
G
--
L
L
D
C
P
H
Y
T
R
P
E
V
L
E
G
L
T
V
P
P
V
L
M
S
G
H
H
E
E
I
R
K
W
R
L
K
Q
S
L
Q
R
T
W
L
R
R
P
E
L
L
----
E
-
G
L
A
----
L
T
D
E
Q
R
K
L
L
K
E
A
Q
A
E
H
N
S
L
EHH
21
PsiBlast_CBE
75.13
46%
-158
- C9 -
4MCC
2
TRMD_HAEIN
B:
[1-243]
--
M
W
I
G
V
I
S
L
F
P
E
M
F
K
A
I
T
E
F
G
V
T
G
R
A
V
K
H
N
L
L
K
V
E
C
W
N
P
R
D
F
T
F
D
K
H
K
T
V
D
D
R
P
Y
G
G
G
P
G
M
L
M
M
V
Q
P
L
R
D
A
I
H
T
A
K
A
----
A
A
----
G
E
G
A
K
V
I
Y
L
S
P
Q
G
R
K
L
D
Q
G
G
V
T
E
L
A
Q
N
Q
K
L
I
L
V
C
G
R
Y
E
G
I
D
E
R
L
I
Q
T
E
----
I
D
E
----
E
W
S
I
G
D
Y
V
L
T
G
G
E
L
P
A
M
T
L
I
D
A
V
A
R
F
I
P
G
V
L
------------
D
-
G
--
L
L
D
C
P
H
Y
T
R
P
E
V
L
E
G
L
T
V
P
P
V
L
M
S
G
H
H
E
E
I
R
K
W
R
L
K
Q
S
L
Q
R
T
W
L
R
R
P
E
L
L
----
E
-
G
L
A
----
L
T
D
E
Q
R
K
L
L
K
E
A
Q
A
E
-------
37
PsiBlast_CBE
75.12
46%
-155
- C9 -
4YQC
1
?
A:
[9-251]
--
M
W
I
G
V
I
S
L
F
P
E
M
F
K
A
I
T
E
F
G
V
T
G
R
A
V
K
H
N
L
L
K
V
E
C
W
N
P
R
D
F
T
F
D
K
H
K
T
V
D
D
R
P
Y
G
G
G
P
G
M
L
M
M
V
Q
P
L
R
D
A
I
H
T
A
K
A
----
A
A
----
G
E
G
A
K
V
I
Y
L
S
P
Q
G
R
K
L
D
Q
G
G
V
T
E
L
A
Q
N
Q
K
L
I
L
V
C
G
R
Y
E
G
I
D
E
R
L
I
Q
T
E
----
I
D
E
----
E
W
S
I
G
D
Y
V
L
T
G
G
E
L
P
A
M
T
L
I
D
A
V
A
R
F
I
P
G
V
L
G
-----------
D
-
G
--
L
L
D
C
P
H
Y
T
R
P
E
V
L
E
G
L
T
V
P
P
V
L
M
S
G
H
H
E
E
I
R
K
W
R
L
K
Q
S
L
Q
R
T
W
L
R
R
P
E
L
L
----
E
-
G
L
A
----
L
T
D
E
Q
R
K
L
L
K
E
A
Q
A
E
-------
36
PsiBlast_CBE
75.11
46%
-154
- C9 -
4YQG
1
?
A:
[9-251]
--
M
W
I
G
V
I
S
L
F
P
E
M
F
K
A
I
T
E
F
G
V
T
G
R
A
V
K
H
N
L
L
K
V
E
C
W
N
P
R
D
F
T
F
D
K
H
K
T
V
D
D
R
P
Y
G
G
G
P
G
M
L
M
M
V
Q
P
L
R
D
A
I
H
T
A
K
A
----
A
A
----
G
E
G
A
K
V
I
Y
L
S
P
Q
G
R
K
L
D
Q
G
G
V
T
E
L
A
Q
N
Q
K
L
I
L
V
C
G
R
Y
E
G
I
D
E
R
L
I
Q
T
E
----
I
D
E
----
E
W
S
I
G
D
Y
V
L
T
G
G
E
L
P
A
M
T
L
I
D
A
V
A
R
F
I
P
G
V
L
G
-----------
D
-
G
--
L
L
D
C
P
H
Y
T
R
P
E
V
L
E
G
L
T
V
P
P
V
L
M
S
G
H
H
E
E
I
R
K
W
R
L
K
Q
S
L
Q
R
T
W
L
R
R
P
E
L
L
----
E
-
G
L
A
----
L
T
D
E
Q
R
K
L
L
K
E
A
Q
A
E
-------
26
PsiBlast_CBE
74.99
46%
-154
- C9 -
4YQT
1
?
A:
[9-251]
--
M
W
I
G
V
I
S
L
F
P
E
M
F
K
A
I
T
E
F
G
V
T
G
R
A
V
K
H
N
L
L
K
V
E
C
W
N
P
R
D
F
T
F
D
K
H
K
T
V
D
D
R
P
Y
G
G
G
P
G
M
L
M
M
V
Q
P
L
R
D
A
I
H
T
A
K
A
----
A
A
----
G
E
G
A
K
V
I
Y
L
S
P
Q
G
R
K
L
D
Q
G
G
V
T
E
L
A
Q
N
Q
K
L
I
L
V
C
G
R
Y
E
G
I
D
E
R
L
I
Q
T
E
----
I
D
E
----
E
W
S
I
G
D
Y
V
L
T
G
G
E
L
P
A
M
T
L
I
D
A
V
A
R
F
I
P
G
V
L
G
-----------
D
-
G
--
L
L
D
C
P
H
Y
T
R
P
E
V
L
E
G
L
T
V
P
P
V
L
M
S
G
H
H
E
E
I
R
K
W
R
L
K
Q
S
L
Q
R
T
W
L
R
R
P
E
L
L
----
E
-
G
L
A
----
L
T
D
E
Q
R
K
L
L
K
E
A
Q
A
E
-------
18
PsiBlast_PDB
74.99
46%
-152
- C9 -
4YPZ
1
?
A:
[9-251]
--
M
W
I
G
V
I
S
L
F
P
E
M
F
K
A
I
T
E
F
G
V
T
G
R
A
V
K
H
N
L
L
K
V
E
C
W
N
P
R
D
F
T
F
D
K
H
K
T
V
D
D
R
P
Y
G
G
G
P
G
M
L
M
M
V
Q
P
L
R
D
A
I
H
T
A
K
A
----
A
A
----
G
E
G
A
K
V
I
Y
L
S
P
Q
G
R
K
L
D
Q
G
G
V
T
E
L
A
Q
N
Q
K
L
I
L
V
C
G
R
Y
E
G
I
D
E
R
L
I
Q
T
E
----
I
D
E
----
E
W
S
I
G
D
Y
V
L
T
G
G
E
L
P
A
M
T
L
I
D
A
V
A
R
F
I
P
G
V
L
------------
D
-
G
--
L
L
D
C
P
H
Y
T
R
P
E
V
L
E
G
L
T
V
P
P
V
L
M
S
G
H
H
E
E
I
R
K
W
R
L
K
Q
S
L
Q
R
T
W
L
R
R
P
E
L
L
----
E
-
G
L
A
----
L
T
D
E
Q
R
K
L
L
K
E
A
Q
A
E
-------
65
HHSearch
74.93
46%
-145
- C9 -
4YQD
1
TRMD_HAEIN
A:
[21-263]
--
M
W
I
G
V
I
S
L
F
P
E
M
F
K
A
I
T
E
F
G
V
T
G
R
A
V
K
H
N
L
L
K
V
E
C
W
N
P
R
D
F
T
F
D
K
H
K
T
V
D
D
R
P
Y
G
G
G
P
G
M
L
M
M
V
Q
P
L
R
D
A
I
H
T
A
K
A
----
A
A
----
G
E
G
A
K
V
I
Y
L
S
P
Q
G
R
K
L
D
Q
G
G
V
T
E
L
A
Q
N
Q
K
L
I
L
V
C
G
R
Y
E
G
I
D
E
R
L
I
Q
T
E
----
I
D
E
----
E
W
S
I
G
D
Y
V
L
T
G
G
E
L
P
A
M
T
L
I
D
A
V
A
R
F
I
P
G
V
L
G
--
A
S
A
---
S
F
A
D
-
G
--
L
L
D
C
P
H
Y
T
R
P
E
V
L
E
G
L
T
V
P
P
V
L
M
S
G
H
H
E
E
I
R
K
W
R
L
K
Q
S
L
Q
R
T
W
L
R
R
P
E
L
L
----
E
-
G
L
A
----
L
T
D
E
Q
R
K
L
L
K
E
A
Q
A
E
-------
14
PsiBlast_PDB
74.93
46%
-145
- C9 -
4YQD
1
TRMD_HAEIN
A:
[21-263]
--
M
W
I
G
V
I
S
L
F
P
E
M
F
K
A
I
T
E
F
G
V
T
G
R
A
V
K
H
N
L
L
K
V
E
C
W
N
P
R
D
F
T
F
D
K
H
K
T
V
D
D
R
P
Y
G
G
G
P
G
M
L
M
M
V
Q
P
L
R
D
A
I
H
T
A
K
A
----
A
A
----
G
E
G
A
K
V
I
Y
L
S
P
Q
G
R
K
L
D
Q
G
G
V
T
E
L
A
Q
N
Q
K
L
I
L
V
C
G
R
Y
E
G
I
D
E
R
L
I
Q
T
E
----
I
D
E
----
E
W
S
I
G
D
Y
V
L
T
G
G
E
L
P
A
M
T
L
I
D
A
V
A
R
F
I
P
G
V
L
G
--
A
S
A
---
S
F
A
D
-
G
--
L
L
D
C
P
H
Y
T
R
P
E
V
L
E
G
L
T
V
P
P
V
L
M
S
G
H
H
E
E
I
R
K
W
R
L
K
Q
S
L
Q
R
T
W
L
R
R
P
E
L
L
----
E
-
G
L
A
----
L
T
D
E
Q
R
K
L
L
K
E
A
Q
A
E
-------
3
PsiBlast_PDB
74.63
46%
-154
- C9 -
1UAL
1
TRMD_HAEIN
A:
[21-263]
--
M
W
I
G
V
I
S
L
F
P
E
M
F
K
A
I
T
E
F
G
V
T
G
R
A
V
K
H
N
L
L
K
V
E
C
W
N
P
R
D
F
T
F
D
K
H
K
T
V
D
D
R
P
Y
G
G
G
P
G
M
L
M
M
V
Q
P
L
R
D
A
I
H
T
A
K
A
----
A
A
----
G
E
G
A
K
V
I
Y
L
S
P
Q
G
R
K
L
D
Q
G
G
V
T
E
L
A
Q
N
Q
K
L
I
L
V
C
G
R
Y
E
G
I
D
E
R
L
I
Q
T
E
----
I
D
E
----
E
W
S
I
G
D
Y
V
L
T
G
G
E
L
P
A
M
T
L
I
D
A
V
A
R
F
I
P
G
V
L
---------
S
F
A
D
-
G
--
L
L
D
C
P
H
Y
T
R
P
E
V
L
E
G
L
T
V
P
P
V
L
M
S
G
H
H
E
E
I
R
K
W
R
L
K
Q
S
L
Q
R
T
W
L
R
R
P
E
L
L
----
E
-
G
L
A
----
L
T
D
E
Q
R
K
L
L
K
E
A
Q
A
E
-------
46
PsiBlast_CBE
74.61
46%
-149
- C9 -
4YQ2
1
?
A:
[9-251]
--
M
W
I
G
V
I
S
L
F
P
E
M
F
K
A
I
T
E
F
G
V
T
G
R
A
V
K
H
N
L
L
K
V
E
C
W
N
P
R
D
F
T
F
D
K
H
K
T
V
D
D
R
P
Y
G
G
G
P
G
M
L
M
M
V
Q
P
L
R
D
A
I
H
T
A
K
A
----
A
A
----
G
E
G
A
K
V
I
Y
L
S
P
Q
G
R
K
L
D
Q
G
G
V
T
E
L
A
Q
N
Q
K
L
I
L
V
C
G
R
Y
E
G
I
D
E
R
L
I
Q
T
E
----
I
D
E
----
E
W
S
I
G
D
Y
V
L
T
G
G
E
L
P
A
M
T
L
I
D
A
V
A
R
F
I
P
G
V
L
------------
D
-
G
--
L
L
D
C
P
H
Y
T
R
P
E
V
L
E
G
L
T
V
P
P
V
L
M
S
G
H
H
E
E
I
R
K
W
R
L
K
Q
S
L
Q
R
T
W
L
R
R
P
E
L
L
----
E
-
G
L
A
----
L
T
D
E
Q
R
K
L
L
K
E
A
Q
A
E
-------
2
PsiBlast_PDB
74.17
46%
-153
- C9 -
1UAK
1
TRMD_HAEIN
A:
[21-263]
--
M
W
I
G
V
I
S
L
F
P
E
M
F
K
A
I
T
E
F
G
V
T
G
R
A
V
K
H
N
L
L
K
V
E
C
W
N
P
R
D
F
T
F
D
K
H
K
T
V
D
D
R
P
Y
G
G
G
P
G
M
L
M
M
V
Q
P
L
R
D
A
I
H
T
A
K
A
----
A
A
----
G
E
G
A
K
V
I
Y
L
S
P
Q
G
R
K
L
D
Q
G
G
V
T
E
L
A
Q
N
Q
K
L
I
L
V
C
G
R
Y
E
G
I
D
E
R
L
I
Q
T
E
----
I
D
E
----
E
W
S
I
G
D
Y
V
L
T
G
G
E
L
P
A
M
T
L
I
D
A
V
A
R
F
I
P
G
V
L
---------
S
F
A
D
-
G
--
L
L
D
C
P
H
Y
T
R
P
E
V
L
E
G
L
T
V
P
P
V
L
M
S
G
H
H
E
E
I
R
K
W
R
L
K
Q
S
L
Q
R
T
W
L
R
R
P
E
L
L
----
E
-
G
L
A
----
L
T
D
E
Q
R
K
L
L
K
E
A
Q
A
E
-------
16
PsiBlast_PDB
73.99
46%
-152
- C9 -
4YPX
1
?
A:
[9-251]
--
M
W
I
G
V
I
S
L
F
P
E
M
F
K
A
I
T
E
F
G
V
T
G
R
A
V
K
H
N
L
L
K
V
E
C
W
N
P
R
D
F
T
F
D
K
H
K
T
V
D
D
R
P
Y
G
G
G
P
G
M
L
M
M
V
Q
P
L
R
D
A
I
H
T
A
K
A
----
A
A
----
G
E
G
A
K
V
I
Y
L
S
P
Q
G
R
K
L
D
Q
G
G
V
T
E
L
A
Q
N
Q
K
L
I
L
V
C
G
R
Y
E
G
I
D
E
R
L
I
Q
T
E
----
I
D
E
----
E
W
S
I
G
D
Y
V
L
T
G
G
E
L
P
A
M
T
L
I
D
A
V
A
R
F
I
P
G
V
L
G
----------
A
D
-
G
--
L
L
D
C
P
H
Y
T
R
P
E
V
L
E
G
L
T
V
P
P
V
L
M
S
G
H
H
E
E
I
R
K
W
R
L
K
Q
S
L
Q
R
T
W
L
R
R
P
E
L
L
----
E
-
G
L
A
----
L
T
D
E
Q
R
K
L
L
K
E
A
Q
A
E
-------
8
PsiBlast_PDB
73.97
46%
-156
- C9 -
3AXZ
1
TRMD_HAEIN
A:
[21-263]
--
M
W
I
G
V
I
S
L
F
P
E
M
F
K
A
I
T
E
F
G
V
T
G
R
A
V
K
H
N
L
L
K
V
E
C
W
N
P
R
D
F
T
F
D
K
H
K
T
V
D
D
R
P
Y
G
G
G
P
G
M
L
M
M
V
Q
P
L
R
D
A
I
H
T
A
K
A
----
A
A
----
G
E
G
A
K
V
I
Y
L
S
P
Q
G
R
K
L
D
Q
G
G
V
T
E
L
A
Q
N
Q
K
L
I
L
V
C
G
R
Y
E
G
I
D
E
R
L
I
Q
T
E
----
I
D
E
----
E
W
S
I
G
D
Y
V
L
T
G
G
E
L
P
A
M
T
L
I
D
A
V
A
R
F
I
P
G
V
L
-----------
A
D
-
G
--
L
L
D
C
P
H
Y
T
R
P
E
V
L
E
G
L
T
V
P
P
V
L
M
S
G
H
H
E
E
I
R
K
W
R
L
K
Q
S
L
Q
R
T
W
L
R
R
P
E
L
L
----
E
-
G
L
A
----
L
T
D
E
Q
R
K
L
L
K
E
A
Q
A
E
-------
17
PsiBlast_PDB
73.83
46%
-148
- C9 -
4YPY
2
?
A:
[9-251]
--
M
W
I
G
V
I
S
L
F
P
E
M
F
K
A
I
T
E
F
G
V
T
G
R
A
V
K
H
N
L
L
K
V
E
C
W
N
P
R
D
F
T
F
D
K
H
K
T
V
D
D
R
P
Y
G
G
G
P
G
M
L
M
M
V
Q
P
L
R
D
A
I
H
T
A
K
A
----
A
A
----
G
E
G
A
K
V
I
Y
L
S
P
Q
G
R
K
L
D
Q
G
G
V
T
E
L
A
Q
N
Q
K
L
I
L
V
C
G
R
Y
E
G
I
D
E
R
L
I
Q
T
E
----
I
D
E
----
E
W
S
I
G
D
Y
V
L
T
G
G
E
L
P
A
M
T
L
I
D
A
V
A
R
F
I
P
G
V
L
---------
S
F
A
D
-
G
--
L
L
D
C
P
H
Y
T
R
P
E
V
L
E
G
L
T
V
P
P
V
L
M
S
G
H
H
E
E
I
R
K
W
R
L
K
Q
S
L
Q
R
T
W
L
R
R
P
E
L
L
----
E
-
G
L
A
----
L
T
D
E
Q
R
K
L
L
K
E
A
Q
A
E
-------
20
PsiBlast_PDB
73.63
46%
-146
- C9 -
4YQ1
1
?
A:
[9-251]
--
M
W
I
G
V
I
S
L
F
P
E
M
F
K
A
I
T
E
F
G
V
T
G
R
A
V
K
H
N
L
L
K
V
E
C
W
N
P
R
D
F
T
F
D
K
H
K
T
V
D
D
R
P
Y
G
G
G
P
G
M
L
M
M
V
Q
P
L
R
D
A
I
H
T
A
K
A
----
A
A
----
G
E
G
A
K
V
I
Y
L
S
P
Q
G
R
K
L
D
Q
G
G
V
T
E
L
A
Q
N
Q
K
L
I
L
V
C
G
R
Y
E
G
I
D
E
R
L
I
Q
T
E
----
I
D
E
----
E
W
S
I
G
D
Y
V
L
T
G
G
E
L
P
A
M
T
L
I
D
A
V
A
R
F
I
P
G
V
L
G
---------
F
A
D
-
G
--
L
L
D
C
P
H
Y
T
R
P
E
V
L
E
G
L
T
V
P
P
V
L
M
S
G
H
H
E
E
I
R
K
W
R
L
K
Q
S
L
Q
R
T
W
L
R
R
P
E
L
L
----
E
-
G
L
A
----
L
T
D
E
Q
R
K
L
L
K
E
A
Q
A
E
-------
7
PsiBlast_PDB
73.59
46%
-153
- C9 -
4MCD
1
TRMD_HAEIN
A:
[1-243]
--
M
W
I
G
V
I
S
L
F
P
E
M
F
K
A
I
T
E
F
G
V
T
G
R
A
V
K
H
N
L
L
K
V
E
C
W
N
P
R
D
F
T
F
D
K
H
K
T
V
D
D
R
P
Y
G
G
G
P
G
M
L
M
M
V
Q
P
L
R
D
A
I
H
T
A
K
A
----
A
A
----
G
E
G
A
K
V
I
Y
L
S
P
Q
G
R
K
L
D
Q
G
G
V
T
E
L
A
Q
N
Q
K
L
I
L
V
C
G
R
Y
E
G
I
D
E
R
L
I
Q
T
E
----
I
D
E
----
E
W
S
I
G
D
Y
V
L
T
G
G
E
L
P
A
M
T
L
I
D
A
V
A
R
F
I
P
G
V
L
---------
S
F
A
D
-
G
--
L
L
D
C
P
H
Y
T
R
P
E
V
L
E
G
L
T
V
P
P
V
L
M
S
G
H
H
E
E
I
R
K
W
R
L
K
Q
S
L
Q
R
T
W
L
R
R
P
E
L
L
----
E
-
G
L
A
----
L
T
D
E
Q
R
K
L
L
K
E
A
Q
A
E
-------
13
PsiBlast_PDB
73.53
46%
-146
- C9 -
4YVK
2
TRMD_HAEIN
A:
[21-263]
--
M
W
I
G
V
I
S
L
F
P
E
M
F
K
A
I
T
E
F
G
V
T
G
R
A
V
K
H
N
L
L
K
V
E
C
W
N
P
R
D
F
T
F
D
K
H
K
T
V
D
D
R
P
Y
G
G
G
P
G
M
L
M
M
V
Q
P
L
R
D
A
I
H
T
A
K
A
----
A
A
----
G
E
G
A
K
V
I
Y
L
S
P
Q
G
R
K
L
D
Q
G
G
V
T
E
L
A
Q
N
Q
K
L
I
L
V
C
G
R
Y
E
G
I
D
E
R
L
I
Q
T
E
----
I
D
E
----
E
W
S
I
G
D
Y
V
L
T
G
G
E
L
P
A
M
T
L
I
D
A
V
A
R
F
I
P
G
V
---------
D
S
F
A
D
-
G
--
L
L
D
C
P
H
Y
T
R
P
E
V
L
E
G
L
T
V
P
P
V
L
M
S
G
H
H
E
E
I
R
K
W
R
L
K
Q
S
L
Q
R
T
W
L
R
R
P
E
L
L
----
E
-
G
L
A
----
L
T
D
E
Q
R
K
L
L
K
E
A
Q
A
E
-------
12
PsiBlast_PDB
73.46
46%
-147
- C9 -
4YVJ
2
TRMD_HAEIN
A:
[21-263]
--
M
W
I
G
V
I
S
L
F
P
E
M
F
K
A
I
T
E
F
G
V
T
G
R
A
V
K
H
N
L
L
K
V
E
C
W
N
P
R
D
F
T
F
D
K
H
K
T
V
D
D
R
P
Y
G
G
G
P
G
M
L
M
M
V
Q
P
L
R
D
A
I
H
T
A
K
A
----
A
A
----
G
E
G
A
K
V
I
Y
L
S
P
Q
G
R
K
L
D
Q
G
G
V
T
E
L
A
Q
N
Q
K
L
I
L
V
C
G
R
Y
E
G
I
D
E
R
L
I
Q
T
E
----
I
D
E
----
E
W
S
I
G
D
Y
V
L
T
G
G
E
L
P
A
M
T
L
I
D
A
V
A
R
F
I
P
G
V
---------
D
S
F
A
D
-
G
--
L
L
D
C
P
H
Y
T
R
P
E
V
L
E
G
L
T
V
P
P
V
L
M
S
G
H
H
E
E
I
R
K
W
R
L
K
Q
S
L
Q
R
T
W
L
R
R
P
E
L
L
----
E
-
G
L
A
----
L
T
D
E
Q
R
K
L
L
K
E
A
Q
A
E
-------
51
PsiBlast_CBE
72.63
40%
-159
- C9 -
4H3Y
2
TRMD_BURP8
A:
[22-272]
--
M
Q
F
D
I
V
T
L
F
P
D
M
F
R
A
L
T
D
W
G
I
T
S
R
A
A
K
Q
E
R
Y
G
L
R
T
W
N
P
R
D
F
T
T
D
N
Y
R
T
I
D
D
R
P
Y
G
G
G
P
G
M
V
M
L
A
R
P
L
E
D
A
I
N
A
A
K
A
A
Q
A
E
Q
G
----
I
G
G
A
R
V
V
M
M
S
P
Q
G
A
T
L
N
H
D
K
V
M
R
F
A
A
E
P
G
L
I
L
L
C
G
R
Y
E
A
I
D
Q
R
L
I
D
R
V
----
V
D
E
----
E
V
S
L
G
D
F
V
L
S
G
G
E
L
P
A
M
A
L
I
D
A
V
V
R
H
L
P
G
V
L
N
D
A
Q
S
A
V
Q
D
S
F
V
D
-
G
--
L
L
D
C
P
H
Y
T
R
P
E
E
Y
D
G
V
R
V
P
D
V
L
L
G
G
H
H
A
E
I
E
Q
W
R
R
R
E
A
L
R
N
T
W
L
K
R
P
D
L
I
V
Q
A
R
K
-
N
K
L
----
L
S
R
A
D
E
A
W
L
A
S
L
A
K
D
-------
67
HHSearch
72.45
42%
-153
* C9 *
4H3Z
4
TRMD_BURP8
A:
[22-271]
--
M
Q
F
D
I
V
T
L
F
P
D
M
F
R
A
L
T
D
W
G
I
T
S
R
A
A
K
Q
E
R
Y
G
L
R
T
W
N
P
R
D
F
T
T
D
N
Y
R
T
I
D
D
R
P
Y
G
G
G
P
G
M
V
M
L
A
R
P
L
E
D
A
I
N
A
A
K
A
----
A
Q
A
E
Q
G
I
G
G
A
R
V
V
M
M
S
P
Q
G
A
T
L
N
H
D
K
V
M
R
F
A
A
E
P
G
L
I
L
L
C
G
R
Y
E
A
I
D
Q
R
L
I
D
R
V
----
V
D
E
----
E
V
S
L
G
D
F
V
L
S
G
G
E
L
P
A
M
A
L
I
D
A
V
V
R
H
L
P
G
V
L
N
------
Q
D
S
F
V
D
-
G
--
L
L
D
C
P
H
Y
T
R
P
E
E
Y
D
G
V
R
V
P
D
V
L
L
G
G
H
H
A
E
I
E
Q
W
R
R
R
E
A
L
R
N
T
W
L
K
R
P
D
L
I
----
V
-
Q
A
R
K
N
KL
L
S
R
A
D
E
A
W
L
A
S
L
A
K
--------
49
PsiBlast_CBE
72.13
40%
-156
- C9 -
4H3Z
4
TRMD_BURP8
A:
[22-272]
--
M
Q
F
D
I
V
T
L
F
P
D
M
F
R
A
L
T
D
W
G
I
T
S
R
A
A
K
Q
E
R
Y
G
L
R
T
W
N
P
R
D
F
T
T
D
N
Y
R
T
I
D
D
R
P
Y
G
G
G
P
G
M
V
M
L
A
R
P
L
E
D
A
I
N
A
A
K
A
A
Q
A
E
Q
G
----
I
G
G
A
R
V
V
M
M
S
P
Q
G
A
T
L
N
H
D
K
V
M
R
F
A
A
E
P
G
L
I
L
L
C
G
R
Y
E
A
I
D
Q
R
L
I
D
R
V
----
V
D
E
----
E
V
S
L
G
D
F
V
L
S
G
G
E
L
P
A
M
A
L
I
D
A
V
V
R
H
L
P
G
V
L
N
------
Q
D
S
F
V
D
-
G
--
L
L
D
C
P
H
Y
T
R
P
E
E
Y
D
G
V
R
V
P
D
V
L
L
G
G
H
H
A
E
I
E
Q
W
R
R
R
E
A
L
R
N
T
W
L
K
R
P
D
L
I
V
Q
A
R
K
-
N
K
L
----
L
S
R
A
D
E
A
W
L
A
S
L
A
K
D
-------
43
PsiBlast_CBE
71.44
46%
-150
- C9 -
4YQ5
2
?
A:
[9-251]
--
M
W
I
G
V
I
S
L
F
P
E
M
F
K
A
I
T
E
F
G
V
T
G
R
A
V
K
H
N
L
L
K
V
E
C
W
N
P
R
D
F
T
F
D
K
H
K
T
V
D
D
R
P
Y
G
G
G
P
G
M
L
M
M
V
Q
P
L
R
D
A
I
H
T
A
K
A
----
A
A
----
G
E
G
A
K
V
I
Y
L
S
P
Q
G
R
K
L
D
Q
G
G
V
T
E
L
A
Q
N
Q
K
L
I
L
V
C
G
R
Y
E
G
I
D
E
R
L
I
Q
T
E
----
I
D
E
----
E
W
S
I
G
D
Y
V
L
T
G
G
E
L
P
A
M
T
L
I
D
A
V
A
R
F
I
P
G
V
L
G
--------
S
F
A
D
-
G
--
L
L
D
C
P
H
Y
T
R
P
E
V
L
E
G
L
T
V
P
P
V
L
M
S
G
H
H
E
E
I
R
K
W
R
L
K
Q
S
L
Q
R
T
W
L
R
R
P
E
L
L
----
E
-
G
L
A
----
L
T
D
E
Q
R
K
L
L
K
E
A
Q
A
E
-------
53
PsiBlast_CBE
71.43
45%
-159
- C9 -
3QUV
2
?
B:
[5-235]
--
M
K
I
D
V
V
T
I
F
P
E
Y
L
Q
P
V
R
-
Q
S
L
P
G
K
A
I
D
A
G
L
V
D
V
A
V
H
D
L
R
R
W
T
H
D
V
H
K
S
V
D
D
S
P
Y
G
G
G
P
G
M
V
M
K
P
T
V
W
G
D
A
L
D
E
I
C
T
----
S
E
----
T
L
---
L
V
V
P
T
P
A
G
Y
P
F
T
Q
E
T
A
W
Q
W
S
T
E
D
H
L
V
I
A
C
G
R
Y
E
G
I
D
Q
R
V
A
D
D
A
----
A
T
R
M
R
V
R
E
V
S
I
G
D
Y
V
L
N
G
G
E
A
A
A
L
V
I
I
E
A
V
L
R
L
V
P
G
V
L
G
N
A
L
S
A
---------AS
L
L
E
G
P
S
Y
T
R
P
P
S
W
R
G
M
D
V
P
P
V
L
L
S
G
D
H
A
K
I
A
A
W
R
A
E
Q
S
R
Q
R
T
I
E
R
R
P
D
L
L
----
G
F
D
S
---------------------------
48
PsiBlast_CBE
71.18
40%
-152
- C9 -
4H3Z
4
TRMD_BURP8
B:
[22-272]
--
M
Q
F
D
I
V
T
L
F
P
D
M
F
R
A
L
T
D
W
G
I
T
S
R
A
A
K
Q
E
R
Y
G
L
R
T
W
N
P
R
D
F
T
T
D
N
Y
R
T
I
D
D
R
P
Y
G
G
G
P
G
M
V
M
L
A
R
P
L
E
D
A
I
N
A
A
K
A
A
Q
A
E
Q
G
----
I
G
G
A
R
V
V
M
M
S
P
Q
G
A
T
L
N
H
D
K
V
M
R
F
A
A
E
P
G
L
I
L
L
C
G
R
Y
E
A
I
D
Q
R
L
I
D
R
V
----
V
D
E
----
E
V
S
L
G
D
F
V
L
S
G
G
E
L
P
A
M
A
L
I
D
A
V
V
R
H
L
P
G
V
L
N
D
A
Q
S
A
V
Q
D
S
F
V
D
-
G
--
L
L
D
C
P
H
Y
T
R
P
E
E
Y
D
G
V
R
V
P
D
V
L
L
G
G
H
H
A
E
I
E
Q
W
R
R
R
E
A
L
R
N
T
W
L
K
R
P
D
L
I
V
Q
A
R
K
-
N
K
L
----
L
S
R
A
D
E
A
W
L
A
S
L
A
K
D
-------
28
PsiBlast_CBE
71.11
46%
-153
- C9 -
4YQQ
1
?
A:
[9-251]
--
M
W
I
G
V
I
S
L
F
P
E
M
F
K
A
I
T
E
F
G
V
T
G
R
A
V
K
H
N
L
L
K
V
E
C
W
N
P
R
D
F
T
F
D
K
H
K
T
V
D
D
R
P
Y
G
G
G
P
G
M
L
M
M
V
Q
P
L
R
D
A
I
H
T
A
K
A
----
A
A
----
G
E
G
A
K
V
I
Y
L
S
P
Q
G
R
K
L
D
Q
G
G
V
T
E
L
A
Q
N
Q
K
L
I
L
V
C
G
R
Y
E
G
I
D
E
R
L
I
Q
T
E
----
I
D
E
----
E
W
S
I
G
D
Y
V
L
T
G
G
E
L
P
A
M
T
L
I
D
A
V
A
R
F
I
P
G
V
L
G
-----------
D
-
G
--
L
L
D
C
P
H
Y
T
R
P
E
V
L
E
G
L
T
V
P
P
V
L
M
S
G
H
H
E
E
I
R
K
W
R
L
K
Q
S
L
Q
R
T
W
L
R
R
P
E
L
L
----
E
-
G
L
A
----
L
T
D
E
Q
R
K
L
L
K
E
A
Q
A
E
-------
54
PsiBlast_CBE
70.36
45%
-170
- C9 -
3QUV
3
?
A:
[5-231]
--
M
K
I
D
V
V
T
I
F
P
E
Y
L
Q
P
V
R
-
Q
S
L
P
G
K
A
I
D
A
G
L
V
D
V
A
V
H
D
L
R
R
W
T
H
D
V
H
K
S
V
D
D
S
P
Y
G
G
G
P
G
M
V
M
K
P
T
V
W
G
D
A
L
D
E
I
C
T
----
S
E
----
T
L
---
L
V
V
P
T
P
A
G
Y
P
F
T
Q
E
T
A
W
Q
W
S
T
E
D
H
L
V
I
A
C
G
R
Y
E
G
I
D
Q
R
V
A
D
D
A
----
A
T
R
M
R
V
R
E
V
S
I
G
D
Y
V
L
N
G
G
E
A
A
A
L
V
I
I
E
A
V
L
R
L
V
P
G
V
L
G
N
-------------AS
L
L
E
G
P
S
Y
T
R
P
P
S
W
R
G
M
D
V
P
P
V
L
L
S
G
D
H
A
K
I
A
A
W
R
A
E
Q
S
R
Q
R
T
I
E
R
R
P
D
L
L
-----------------------------------
52
PsiBlast_CBE
69.06
45%
-162
- C9 -
4IG6
3
TRMD_ANAPZ
A:
[22-243]
--
M
I
F
N
V
L
T
I
F
P
Q
M
F
P
G
P
L
G
V
S
N
L
G
S
A
L
K
K
G
L
W
T
L
N
V
F
D
I
R
A
F
A
N
N
K
H
N
T
V
D
D
T
P
Y
G
G
G
P
G
M
L
L
R
A
D
V
L
G
R
C
I
D
E
V
L
S
----
L
H
----
P
N
T
-
K
L
M
F
T
S
P
R
G
V
S
F
T
Q
D
I
A
R
Q
T
M
N
F
D
N
I
T
L
L
C
G
R
F
E
G
I
D
E
R
V
V
D
F
Y
----
K
L
Q
----
E
V
S
I
G
D
Y
V
L
S
G
G
E
L
A
A
M
V
I
I
D
T
C
V
R
M
V
P
G
V
I
G
N
A
E
S
L
K
Q
E
S
M
E
--
G
--
S
L
E
Y
P
Q
Y
T
R
P
A
S
W
K
G
M
E
V
P
E
V
L
L
T
G
N
H
G
E
I
E
K
W
R
R
N
A
S
L
S
I
T
A
A
R
R
P
D
L
L
-----------------------------------
6
PsiBlast_PDB
68.61
46%
-162
- C9 -
4MCC
1
TRMD_HAEIN
A:
[1-219]
--
M
W
I
G
V
I
S
L
F
P
E
M
F
K
A
I
T
E
F
G
V
T
G
R
A
V
K
H
N
L
L
K
V
E
C
W
N
P
R
D
F
T
F
D
K
H
K
T
V
D
D
R
P
Y
G
G
G
P
G
M
L
M
M
V
Q
P
L
R
D
A
I
H
T
A
K
A
----
A
A
----
G
E
G
A
K
V
I
Y
L
S
P
Q
G
R
K
L
D
Q
G
G
V
T
E
L
A
Q
N
Q
K
L
I
L
V
C
G
R
Y
E
G
I
D
E
R
L
I
Q
T
E
----
I
D
E
----
E
W
S
I
G
D
Y
V
L
T
G
G
E
L
P
A
M
T
L
I
D
A
V
A
R
F
I
P
G
V
L
G
----------------
L
L
D
C
P
H
Y
T
R
P
E
V
L
E
G
L
T
V
P
P
V
L
M
S
G
H
H
E
E
I
R
K
W
R
L
K
Q
S
L
Q
R
T
W
L
R
----------------------------------------
70
HHSearch
68.03
45%
-160
- C9 -
3QUV
3
?
A:
[5-231]
--
M
K
I
D
V
V
T
I
F
P
E
Y
L
Q
-
P
V
R
Q
S
L
P
G
K
A
I
D
A
G
L
V
D
V
A
V
H
D
L
R
R
W
T
H
D
V
H
K
S
V
D
D
S
P
Y
G
G
G
P
G
M
V
M
K
P
T
V
W
G
D
A
L
D
E
I
C
T
-----------
S
E
T
L
L
V
V
P
T
P
A
G
Y
P
F
T
Q
E
T
A
W
Q
W
S
T
E
D
H
L
V
I
A
C
G
R
Y
E
G
I
D
Q
R
V
A
D
D
A
A
T
R
M
R
V
R
----
E
V
S
I
G
D
Y
V
L
N
G
G
E
A
A
A
L
V
I
I
E
A
V
L
R
L
V
P
G
V
L
G
N
-----------A
S
--
L
L
E
G
P
S
Y
T
R
P
P
S
W
R
G
M
D
V
P
P
V
L
L
S
G
D
H
A
K
I
A
A
W
R
A
E
Q
S
R
Q
R
T
I
E
R
R
P
D
L
L
-----------------------------------
5
PsiBlast_PDB
68.02
46%
-160
- C9 -
4MCB
3
TRMD_HAEIN
A:
[1-219]
--
M
W
I
G
V
I
S
L
F
P
E
M
F
K
A
I
T
E
F
G
V
T
G
R
A
V
K
H
N
L
L
K
V
E
C
W
N
P
R
D
F
T
F
D
K
H
K
T
V
D
D
R
P
Y
G
G
G
P
G
M
L
M
M
V
Q
P
L
R
D
A
I
H
T
A
K
A
----
A
A
----
G
E
G
A
K
V
I
Y
L
S
P
Q
G
R
K
L
D
Q
G
G
V
T
E
L
A
Q
N
Q
K
L
I
L
V
C
G
R
Y
E
G
I
D
E
R
L
I
Q
T
E
----
I
D
E
----
E
W
S
I
G
D
Y
V
L
T
G
G
E
L
P
A
M
T
L
I
D
A
V
A
R
F
I
P
G
V
L
G
----------------
L
L
D
C
P
H
Y
T
R
P
E
V
L
E
G
L
T
V
P
P
V
L
M
S
-
H
H
E
E
I
R
K
W
R
L
K
Q
S
L
Q
R
T
W
L
R
----------------------------------------