@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : bsu16120: (2016-06-25 )
MSDYLVIVESPAKAKTIERYLGKKYKVKASMGHVRDLPKSQMGVDIEQNFEPKYITIRGKGPVLKELKTAAKKAKKVYLAADPDREGEAIAWHLAHSLDLDLNSDCRVVFNEITKDAIKESFKHPRMINMDLVDAQQARRILDRLVGYKISPILWKKVKKGLSAGRVQSVALRLIIDREKEINDFKPEEYWTIDGTFLKGQETFEASFFGKNGKKLPLNSEADVKEILSQLKGNQYTVEKVTKKERKRNPALPFTTSTLQQEAARKLNFRAKKTMMIAQQLYEGIDLGREGTVGLITYMRTDSTRISNTAVDEAAAFIDQTYGKEFLGGKRKPAKKNENAQDAHEAIRPTSVLRKPSELKAVLGRDQMRLYKLIWERFVASQMAPAVLDTMSVDLTNNGLTFRANGSKVKFSGFMKVYVEGKDDQMEEKDRMLPDLQEGDTVLSKDIEPEQHFTQPPPRYTEARLVKTLEERGIGRPSTYAPTLDTIQRRGYVALDNKRFVPTELGQIVLDLIMEFFPEIINVEFTAKMERDLDHVEEGNTEWVKIIDNFYTDFEKRVKKAESEMKEVEIEPEYAGEDCELCSSPMVYKMGRYGKFLACSNFPDCRNTKPIVKQIGVKCPSCGEGNIVERKSKKKRVFYGCDRYPDCEFVSWDKPIERKCPKCGKMLVEKKLKKGIQVQCVECDYKEEPQK
Atome Classification :
(20 SA)
.........10........20........30........40-------------.--------------.-----------.-----.-----.....50........60........70........80........90........100.......110.......120.......130.......140.......150.......160.......170.......180.......190.----..-...---.200------.-.......210.------------------...-...------------------220....-------...230.-......240.......250.......260.......270.......280.......290.......300.......310.......320......-.-330.......340.......350..-......360-...---......370.......380.......390....----..----.400.......--410.........420..----.----....430.......440.......450.......460.......470.......480.......490.......500.......510.......520.......530.......540.......550.......560....---.---.----.---570---..---......580.......590.......600.-----......610.------------------....------------------..620.......630.......640......----------.650..---------.....660.......670.......680-.--.......690
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MS
D
Y
L
V
I
VESPAK
A
K
T
I
E
R
Y
LGK
K
Y
K
V
K
ASMG
H
V
RDL
P
K
S
--------------Q--------------M-----------G-----V-----DIEQNFEP
K
Y
I
T
I
RGKG
P
V
L
K
E
L
K
T
A
A
K
KA
K
K
V
Y
L
A
ADPDREG
E
A
I
A
W
H
L
A
H
S
LDLDLNS
D
C
R
V
V
F
N
E
I
T
K
D
A
I
K
E
S
FKHP
R
M
I
N
M
D
LV
D
A
Q
Q
A
R
R
I
L
D
R
L
VGYKI
S
P
I
L
W
K
K
V
K
KGLSAG
R
V
Q
S
V
A
L
R
L
I
IDREKEINDFKPE
E
Y
W
T
I----D
G
-
T
F
L---KGQ-------E-
T
F
E
A
S
FFGKNG------------------KKL-PLN------------------S
E
A
D
V
K
E
-------
I
L
S
Q
LKG-NQ
Y
T
V
E
K
V
T
K
K
E
RKRNPALPF
T
T
S
T
L
Q
Q
E
A
A
R
KLNF
R
A
K
K
T
M
M
I
A
Q
Q
L
Y
E
G
IDLGREG
T
V
G
L
I
T
Y
M
RTDSTRISNT
A
V
D
E
A
A
A
F
I
D
Q
T
Y
G
K
E
FLG-G-KRKPAKKNE
N
A
Q
D
A
H
E
AIR
P
T
S
-
V
L-R
K
P
S
E
L
K
---
A
V
L
---
G
R
D
Q
M
R
L
Y
K
L
I
W
E
R
F
V
A
S
Q
M
A
P
A
V
L
D
T
M
S
V
D
LT----NN----
G
L
T
F
RANG
S
K
V
--
K
--
F
S
G
F
M
K
V
Y
V
EGKDD----
Q
----
M
E
E
K
D
RMLPDLQEGD
T
V
L
SKDIEPEQHFTQPPPR
Y
T
E
A
R
L
V
K
T
L
E
E
RGIGRPSTYAP
T
L
D
T
I
Q
RR
G
Y
V
ALDNKRF
V
P
T
E
L
G
Q
I
V
L
D
L
I
M
E
F
F
P
E
I
IN
V
E
F
T
A
K
M
E
R
D
L
D
H
V
EEGN
T
E
W
V
K
I
I
D
N
F
Y
T
D
F
E
K
R
V
K
K
A
E
S
E
M
K
---
E
---
V
----
E
---IE----PE---YAG
E
D
C
E
LCSS
P
M
V
Y
KMGRYG
K
F
L
A
CSNFP-----DCRNT
K
P
I
V
K
------------------
Q
IGV------------------KCPSCGEG
N
I
V
E
R
KSKKK
R
V
F
YGCDRYPDCE----------FVSWDK---------
P
I
E
R
K
C
P
K
C
G
K
M
L
V
E
K
K
L
KKG
I
Q
V
Q
C
V
--E--CDYKEEPQK
24
HHSearch
80.51
43%
-70
- C4 -
4RUL
9
TOP1_ECOLI
A:
[4-755]
-
G
K
A
L
V
I
V
E
S
P
A
K
A
K
T
I
N
K
Y
L
G
S
D
Y
V
V
K
S
S
V
G
H
I
R
D
L
P
T
-------------------------------K
D
E
R
G
A
L
V
N
R
M
G
-----
V
-----
D
P
W
H
N
W
E
A
H
Y
E
V
L
P
G
K
E
K
V
V
S
E
L
K
Q
L
A
E
K
A
D
H
I
Y
L
A
T
D
L
D
R
E
G
E
A
I
A
W
H
L
R
E
V
I
G
G
D
D
A
R
Y
S
R
V
V
F
N
E
I
T
K
N
A
I
R
Q
A
F
N
K
P
G
E
L
N
I
D
R
V
N
A
Q
Q
A
R
R
F
M
D
R
V
V
G
Y
M
V
S
P
L
L
W
K
K
I
A
R
G
L
S
A
G
R
V
Q
S
V
A
V
R
L
V
V
E
R
E
R
E
I
K
A
F
V
P
E
E
F
W
E
V
----
D
A
-
S
T
T
---
T
P
S
G------
E
-
A
L
A
L
Q
V
T
H
Q
N
D
------------------
K
P
F
-
R
P
V
------------------
N
K
E
Q
T
Q
A
-------
A
V
S
L
L
E
K
-
A
R
Y
S
V
L
E
R
E
D
K
P
T
T
S
K
P
G
A
P
F
I
T
S
T
L
Q
Q
A
A
S
T
R
L
G
F
G
V
K
K
T
M
M
M
A
Q
R
L
Y
E
---------
A
G
Y
I
T
Y
M
R
T
D
S
T
N
L
S
Q
D
A
V
N
M
V
R
G
Y
I
S
D
N
F
G
K
K
Y
L
P
-
E
S
P
N
Q
Y
A
S
K
----
Q
E
A
H
E
A
I
R
P
S
D
-
V
N
-
V
M
A
E
S
L
----
K
D
M
---
E
A
D
A
Q
K
L
Y
Q
L
I
W
R
Q
F
V
A
C
Q
M
T
P
A
K
Y
D
S
T
T
L
T
V
G
----
A
G
----
D
F
R
L
K
A
R
G
R
I
L
--
R
--
F
D
G
W
T
K
V
M
P
A
L
R
K
G
-----------
D
E
D
R
I
L
P
A
V
N
K
G
D
A
L
T
L
V
E
L
T
P
A
Q
H
F
T
K
P
P
A
R
F
S
E
A
S
L
V
K
E
L
E
K
R
G
I
G
R
P
S
T
Y
A
S
I
I
S
T
I
Q
D
R
G
Y
V
R
V
E
N
R
R
F
Y
A
E
K
M
G
E
I
V
T
D
R
L
E
E
N
F
R
E
L
M
N
Y
D
F
T
A
Q
M
E
N
S
L
D
Q
V
A
N
H
E
A
E
W
K
A
V
L
D
H
F
F
S
D
F
T
Q
Q
L
D
K
A
E
K
D
P
E
---
E
---
G
GMR
P
N
---
Q
M
----
V
L
---
T
S
I
-
D
C
P
T
C
G
R
K
M
G
I
R
T
A
S
T
G
V
F
L
G
C
S
G
Y
A
LPPKE
R
C
K
T
T
I
N
L
V
P
E
NEVLNVLEGED
A
E
T
N
A
L
R
A
K
R
------------------
R
C
P
K
C
G
T
A
M
D
S
Y
L
I
D
P
-
K
R
K
L
H
V
C
G
N
N
P
T
C
D
----------
G
Y
E
I
E
E
G
E
F
R
I
KGYD
G
P
I
V
E
C
E
K
C
G
S
E
M
H
L
K
M
G
R
F
G
K
Y
M
A
C
T
--
N
EE
C
K
N
T
-----
1
PsiBlast_PDB
79.36
40%
-69
- C4 -
4RUL
9
TOP1_ECOLI
A:
[7-752]
----
L
V
I
V
E
S
P
A
K
A
K
T
I
N
K
Y
L
G
S
D
Y
V
V
K
S
S
V
G
H
I
R
D
L
P
T
-K
D
E
R
G
A
L
V
N
-----
R
--------------
M
-----------
G
-----
V
-----
D
P
W
H
N
W
E
A
H
Y
E
V
L
P
G
K
E
K
V
V
S
E
L
K
Q
L
A
E
K
A
D
H
I
Y
L
A
T
D
L
D
R
E
G
E
A
I
A
W
H
L
R
E
V
I
G
G
D
D
A
R
Y
S
R
V
V
F
N
E
I
T
K
N
A
I
R
Q
A
F
N
K
P
G
E
L
N
I
D
R
V
N
A
Q
Q
A
R
R
F
M
D
R
V
V
G
Y
M
V
S
P
L
L
W
K
K
I
A
R
G
L
S
A
G
R
V
Q
S
V
A
V
R
L
V
V
E
R
E
R
E
I
K
A
F
V
P
E
E
F
W
E
V
----
D
A
S
T
T
T
---
P
S
G
-------
E
-
A
L
A
L
Q
V
T
H
Q
N
D
------------------
K
P
F
R
P
V
N
------------------
K
E
-
Q
T
Q
A
-------
A
V
S
L
L
E
K
-
A
R
Y
S
V
L
E
R
E
D
K
P
T
T
S
K
P
G
A
P
F
I
T
S
T
L
Q
Q
A
A
S
T
R
L
G
F
G
V
K
K
T
M
M
M
A
Q
R
L
Y
E
A
---------
G
Y
I
T
Y
M
R
T
D
S
T
N
L
S
Q
D
A
V
N
M
V
R
G
Y
I
S
D
N
F
G
K
K
Y
L
P
-
E
-
S
P
N
Q
Y
A
S
K
---
Q
E
A
H
E
A
I
R
P
S
D
-
V
N
-
V
M
A
E
S
L
K
---
D
M
E
---
A
-
D
A
Q
K
L
Y
Q
L
I
W
R
Q
F
V
A
C
Q
M
T
P
A
K
Y
D
S
T
T
L
T
V
G
----
A
G
----
D
F
R
L
K
A
R
G
R
I
L
--
R
--
F
D
G
W
T
K
V
M
P
A
L
R
K
G
-----------
D
E
D
R
I
L
P
A
V
N
K
G
D
A
L
T
L
V
E
L
T
P
A
Q
H
F
T
K
P
P
A
R
F
S
E
A
S
L
V
K
E
L
E
K
R
G
I
G
R
P
S
T
Y
A
S
I
I
S
T
I
Q
D
R
G
Y
V
R
V
E
N
R
R
F
Y
A
E
K
M
G
E
I
V
T
D
R
L
E
E
N
F
R
E
L
M
N
Y
D
F
T
A
Q
M
E
N
S
L
D
Q
V
A
N
H
E
A
E
W
K
A
V
L
D
H
F
F
S
D
F
T
Q
Q
L
D
K
A
E
K
D
P
E
---
E
---
G
----
G
---
M
R
----
P
N
Q
M
V
L
T
S
I
D
C
P
T
C
G
R
K
M
G
I
R
T
A
S
T
G
V
F
L
G
C
S
G
Y
A
LPPKE
R
C
K
T
T
I
N
L
V
P
------------------
E
N
E
V
LNVLEGED
A
E
T
N
A
L
R
A
KR
R
C
P
K
C
G
T
A
-
M
D
S
Y
L
I
D
P
K
R
K
L
H
V
C
G
N
N
P
T
C
D
G
Y
E
I
E
E
G
E
F
R
I
K
G
Y
D
G
---------
P
I
V
-
E
C
E
K
C
G
S
E
M
H
L
K
M
G
R
F
G
K
Y
M
A
C
T
NE
E
--
C
--------
4
PsiBlast_PDB
75.31
44%
-82
- C4 -
1CY6
4
TOP1_ECOLI
A:
[4-591]
-
G
K
A
L
V
I
V
E
S
P
A
K
A
K
T
I
N
K
Y
L
G
S
D
Y
V
V
K
S
S
V
G
H
I
R
D
L
P
T
-DER
G
A
L
V
N
------
R
--------------
M
-----------
G
-----
V
-----
D
P
W
H
N
W
E
A
H
Y
E
V
L
P
G
K
E
K
V
V
S
E
L
K
Q
L
A
E
K
A
D
H
I
Y
L
A
T
D
L
D
R
E
G
E
A
I
A
W
H
L
R
E
V
I
G
G
D
D
A
R
Y
S
R
V
V
F
N
E
I
T
K
N
A
I
R
Q
A
F
N
K
P
G
E
L
N
I
D
R
V
N
A
Q
Q
A
R
R
F
M
D
R
V
V
G
Y
M
V
S
P
L
L
W
K
K
I
A
R
G
L
S
A
G
R
V
Q
S
V
A
V
R
L
V
V
E
R
E
R
E
I
K
A
F
V
P
E
E
F
W
E
V
----
D
A
S
T
T
T
---
P
S
G
-------
E
-
A
L
A
L
Q
V
T
H
Q
N
D
------------------
K
P
F
R
P
V
N
------------------
K
E
-
Q
T
Q
A
-------
A
V
S
L
L
E
K
-
A
R
Y
S
V
L
E
R
E
D
K
P
T
T
S
K
P
G
A
P
F
I
T
S
T
L
Q
Q
A
A
S
T
R
L
G
F
G
V
K
K
T
M
M
M
A
Q
R
L
Y
E
A
---------
G
Y
I
T
Y
M
R
T
D
S
T
N
L
S
Q
D
A
V
N
M
V
R
G
Y
I
S
D
N
F
G
K
K
Y
L
P
-
E
-
S
P
N
Q
Y
A
-------
A
H
E
A
I
R
P
S
D
-
V
N
-
V
M
A
E
S
L
K
---
D
-
M
---
E
A
D
A
Q
K
L
Y
Q
L
I
W
R
Q
F
V
A
C
Q
M
T
P
A
K
Y
D
S
T
T
L
T
V
G
----
A
G
----
D
F
R
L
K
A
R
G
R
I
L
--
R
--
F
D
G
W
T
K
V
M
P
A
L
R
--------------
E
D
R
I
L
P
A
V
N
K
G
D
A
L
T
L
V
E
L
T
P
A
Q
H
F
T
K
P
P
A
R
F
S
E
A
S
L
V
K
E
L
E
K
R
G
I
G
R
P
S
T
Y
A
S
I
I
S
T
I
Q
D
R
G
Y
V
R
V
E
N
R
R
F
Y
A
E
K
M
G
E
I
V
T
D
R
L
E
E
N
F
R
E
L
M
N
Y
D
F
T
A
Q
M
E
N
S
L
D
Q
V
A
N
H
E
A
E
W
K
A
V
L
D
H
F
F
S
D
F
T
Q
Q
L
D
K
A
E
K
D
P
E
---
E
---
G
----
G
---
M
R
----
P
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
28
HHSearch
74.89
47%
-77
- C4 -
1MW9
9
TOP1_ECOLI
X:
[2-581]
-
G
K
A
L
V
I
V
E
S
P
A
K
A
K
T
I
N
K
Y
L
G
S
D
Y
V
V
K
S
S
V
G
H
I
R
D
L
P
T
-------------------------------------------ERGAL
V
NRMGV
D
P
W
H
N
W
E
A
H
Y
E
V
L
P
G
K
E
K
V
V
S
E
L
K
Q
L
A
E
K
A
D
H
I
Y
L
A
T
D
L
D
R
E
G
E
A
I
A
W
H
L
R
E
V
I
G
G
D
D
A
R
Y
S
R
V
V
F
N
E
I
T
K
N
A
I
R
Q
A
F
N
K
P
G
E
L
N
I
D
R
V
N
A
Q
Q
A
R
R
F
M
D
R
V
V
G
Y
M
V
S
P
L
L
W
K
K
I
A
R
G
L
S
A
G
R
V
Q
S
V
A
V
R
L
V
V
E
R
E
R
E
I
K
A
F
V
P
E
E
F
W
E
V
----
D
A
-
S
T
T
---
T
P
S
-------
G
E
A
L
A
L
Q
V
T
H
Q
N
D
------------------
K
P
F
-
R
P
V
------------------
N
K
E
Q
T
Q
A
-------
A
V
S
L
L
E
K
-
A
R
Y
S
V
L
E
R
E
D
K
P
T
T
S
K
P
G
A
P
F
I
T
S
T
L
Q
Q
A
A
S
T
R
L
G
F
G
V
K
K
T
M
M
M
A
Q
R
L
Y
E
---------
A
G
Y
I
T
Y
M
R
T
D
S
T
N
L
S
Q
D
A
V
N
M
V
R
G
Y
I
S
D
N
F
G
K
K
Y
L
P
-
E
S
P
N
Q
Y
A
---------
R
E
A
I
R
P
S
D
-
V
N
-
V
M
A
E
S
L
----
K
D
M
---
E
A
D
A
Q
K
L
Y
Q
L
I
W
R
Q
F
V
A
C
Q
M
T
P
A
K
Y
D
S
T
T
L
T
V
G
----
A
G
----
D
F
R
L
K
A
R
G
R
I
L
--
R
--
F
D
G
W
T
K
V
M
P
A
L
---------------
E
D
R
I
L
P
A
V
N
K
G
D
A
L
T
L
V
E
L
T
P
A
Q
H
F
T
K
P
P
A
R
F
S
E
A
S
L
V
K
E
L
E
K
R
G
I
G
R
P
S
T
Y
A
S
I
I
S
T
I
Q
D
R
G
Y
V
R
V
E
N
R
R
F
Y
A
E
K
M
G
E
I
V
T
D
R
L
E
E
N
F
R
E
L
M
N
Y
D
F
T
A
Q
M
E
N
N
L
D
Q
V
A
N
H
E
A
E
W
K
A
V
L
D
H
F
F
S
D
F
T
Q
Q
L
D
K
A
E
K
D
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
12
PsiBlast_PDB
74.84
44%
-87
- C4 -
3PX7
3
TOP1_ECOLI
A:
[2-589]
-
G
K
A
L
V
I
V
E
S
P
A
K
A
K
T
I
N
K
Y
L
G
S
D
Y
V
V
K
S
S
V
G
H
I
R
D
L
P
--DER
G
A
L
V
N
------
R
--------------
M
-----------
G
-----
V
-----
D
P
W
H
N
W
E
A
H
Y
E
V
L
P
G
K
E
K
V
V
S
E
L
K
Q
L
A
E
K
A
D
H
I
Y
L
A
T
N
L
D
R
E
G
E
A
I
A
W
H
L
R
E
V
I
G
G
D
D
A
R
Y
S
R
V
V
F
N
E
I
T
K
N
A
I
R
Q
A
F
N
K
P
G
E
L
N
I
D
R
V
N
A
Q
Q
A
R
R
F
M
D
R
V
V
G
Y
M
V
S
P
L
L
W
K
K
I
A
R
G
L
S
A
G
R
V
Q
S
V
A
V
R
L
V
V
E
R
E
R
E
I
K
A
F
V
P
E
E
F
W
E
V
----
D
A
S
T
T
T
---
P
S
G
-------
E
-
A
L
A
L
Q
V
T
H
Q
N
D
------------------
K
P
F
R
P
V
N
------------------
K
E
-
Q
T
Q
A
-------
A
V
S
L
L
E
K
-
A
R
Y
S
V
L
E
R
E
D
K
P
T
T
S
K
P
G
A
P
F
I
T
S
T
L
Q
Q
A
A
S
T
R
L
G
F
G
V
K
K
T
M
M
M
A
Q
R
L
Y
E
A
---------
G
Y
I
T
Y
M
R
T
D
S
T
N
L
S
Q
D
A
V
N
M
V
R
G
Y
I
S
D
N
F
G
K
K
Y
L
P
-
E
-
S
P
N
Q
Y
A
--------
H
E
A
I
R
P
S
D
-
V
N
-
V
M
A
E
S
L
K
---
D
-
M
---
E
A
D
A
Q
K
L
Y
Q
L
I
W
R
Q
F
V
A
C
Q
M
T
P
A
K
Y
D
S
T
T
L
T
V
G
----
A
G
----
D
F
R
L
K
A
R
G
R
I
L
--
R
--
F
D
G
W
T
K
V
M
P
A
L
R
-----------------
I
L
P
A
V
N
K
G
D
A
L
T
L
V
E
L
T
P
A
Q
H
F
T
K
P
P
A
R
F
S
E
A
S
L
V
K
E
L
E
K
R
G
I
G
R
P
S
T
Y
A
S
I
I
S
T
I
Q
D
R
G
Y
V
R
V
E
N
R
R
F
Y
A
E
K
M
G
E
I
V
T
D
R
L
E
E
N
F
R
E
L
M
N
Y
D
F
T
A
Q
M
E
N
S
L
D
Q
V
A
N
H
E
A
E
W
K
A
V
L
D
H
F
F
S
D
F
T
Q
Q
L
D
K
A
E
K
D
P
E
---
E
---
G
----
G
---
M
R
----
P
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
10
PsiBlast_PDB
74.61
44%
-74
- C4 -
1MW8
7
TOP1_ECOLI
X:
[2-589]
-
G
K
A
L
V
I
V
E
S
P
A
K
A
K
T
I
N
K
Y
L
G
S
D
Y
V
V
K
S
S
V
G
H
I
R
D
L
P
T
S
GDERGALVN-----
R
--------------
M
-----------
G
-----
V
-----
D
P
W
H
N
W
E
A
H
Y
E
V
L
P
G
K
E
K
V
V
S
E
L
K
Q
L
A
E
K
A
D
H
I
Y
L
A
T
D
L
D
R
E
G
E
A
I
A
W
H
L
R
E
V
I
G
G
D
D
A
R
Y
S
R
V
V
F
N
E
I
T
K
N
A
I
R
Q
A
F
N
K
P
G
E
L
N
I
D
R
V
N
A
Q
Q
A
R
R
F
M
D
R
V
V
G
Y
M
V
S
P
L
L
W
K
K
I
A
R
G
L
S
A
G
R
V
Q
S
V
A
V
R
L
V
V
E
R
E
R
E
I
K
A
F
V
P
E
E
F
W
E
V
----
D
A
S
T
T
T
---
P
S
G
-------
E
-
A
L
A
L
Q
V
T
H
Q
N
D
------------------
K
P
F
R
P
V
N
------------------
K
E
-
Q
T
Q
A
-------
A
V
S
L
L
E
K
-
A
R
Y
S
V
L
E
R
E
D
K
P
T
T
S
K
P
G
A
P
F
I
T
S
T
L
Q
Q
A
A
S
T
R
L
G
F
G
V
K
K
T
M
M
M
A
Q
R
L
Y
E
A
---------
G
Y
I
T
Y
M
R
T
D
S
T
N
L
S
Q
D
A
V
N
M
V
R
G
Y
I
S
D
N
F
G
K
K
Y
L
P
-
E
-
S
P
N
Q
Y
A
S
-----
E
A
R
E
A
I
R
P
S
D
-
V
N
-
V
M
A
E
S
L
K
---
D
M
E
---
A
-
D
A
Q
K
L
Y
Q
L
I
W
R
Q
F
V
A
C
Q
M
T
P
A
K
Y
D
S
T
T
L
T
V
G
----
A
G
----
D
F
R
L
K
A
R
G
R
I
L
--
R
--
F
D
G
W
T
K
V
M
P
A
----------------
E
D
R
I
L
P
A
V
N
K
G
D
A
L
T
L
V
E
L
T
P
A
Q
H
F
T
K
P
P
A
R
F
S
E
A
S
L
V
K
E
L
E
K
R
G
I
G
R
P
S
T
Y
A
S
I
I
S
T
I
Q
D
R
G
Y
V
R
V
E
N
R
R
F
Y
A
E
K
M
G
E
I
V
T
D
R
L
E
E
N
F
R
E
L
M
N
Y
D
F
T
A
Q
M
E
N
N
L
D
Q
V
A
N
H
E
A
E
W
K
A
V
L
D
H
F
F
S
D
F
T
Q
Q
L
D
K
A
E
K
D
P
E
---
E
---
G
----
G
---
M
R
----
P
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
25
HHSearch
74.28
43%
-52
- C4 -
5D5H
8
TOP1_MYCTU
A:
[19-676]
-
G
R
R
L
V
I
V
E
S
P
T
K
A
R
K
L
A
S
Y
L
G
S
G
Y
I
V
E
S
S
R
G
H
I
R
D
L
P
R
A
--------------
A
SDVPAKYKSQPWAR
L
-----------
G
-----
V
-----
N
V
D
A
D
F
E
P
L
Y
I
I
S
P
E
K
R
S
T
V
S
E
L
R
G
L
L
K
D
V
D
E
L
Y
L
A
T
D
G
D
R
E
G
E
A
I
A
W
H
L
L
E
T
L
K
P
R
-
I
P
V
K
R
M
V
F
H
E
I
T
E
P
A
I
R
A
A
A
E
H
P
R
D
L
D
I
D
L
V
D
A
Q
E
T
R
R
I
L
D
R
L
Y
G
Y
E
V
S
P
V
L
W
K
K
V
A
P
K
L
S
A
G
R
V
Q
S
V
A
T
R
I
I
V
A
R
E
R
D
R
M
A
F
R
S
A
A
Y
W
D
I
----
L
A
-
K
L
D
---
A
S
V
SDPDAAP
P
-
T
F
S
A
R
L
T
A
V
A
G
RRVATGRDFDSLGTLRKG
D
E
V
-
I
V
L
------------------
D
E
G
S
A
T
A
-------
L
A
A
G
L
D
G
-
T
Q
L
T
V
A
S
A
E
E
K
P
Y
A
R
R
P
Y
P
P
F
M
T
S
T
L
Q
Q
E
A
S
R
K
L
R
F
S
A
E
R
T
M
S
I
A
Q
R
L
Y
E
---------
N
G
Y
I
T
Y
M
R
T
D
S
T
T
L
S
E
S
A
I
N
A
A
R
T
Q
A
R
Q
L
Y
G
D
E
Y
V
A
-
P
A
P
R
Q
Y
T
R
K
V
K
N
A
Q
E
A
H
E
A
I
R
P
A
G
-
E
T
F
A
T
P
D
A
V
R
R
E
L
D
G
P
---
N
I
D
D
F
R
L
Y
E
L
I
W
Q
R
T
V
A
S
Q
M
A
D
A
R
G
M
T
L
S
L
R
I
T
----
G
M
SGH
Q
E
V
V
F
S
A
T
G
R
T
L
--
T
--
F
P
G
F
L
K
A
Y
V
E
T
V
D
E
----
L
V
G
G
E
A
D
D
A
E
R
R
L
P
H
L
T
P
G
Q
R
L
D
I
V
E
L
T
P
D
G
H
A
T
N
P
P
A
R
Y
T
E
A
S
L
V
K
A
L
E
E
L
G
I
G
R
P
S
T
Y
S
S
I
I
K
T
I
Q
D
R
G
Y
V
H
K
K
G
S
A
L
V
P
S
W
V
A
F
A
V
T
G
L
L
E
Q
H
F
G
R
L
V
D
Y
D
F
T
A
A
M
E
D
E
L
D
E
I
A
A
G
N
E
R
R
T
N
W
L
N
N
F
Y
F
G
G
D
H
G
V
P
D
S
V
A
R
S
G
G
L
K
K
L
V
G
I
----
N
LEG
I
D
A
R
E
V
N
S
---
I
K
L
-
F
D
D
T
H
G
R
P
I
Y
V
R
V
G
K
N
G
P
Y
L
E
R
L
V
A
G
-----
D
T
-------------------------------------------------------------------------------------------------------------------------------------------------
11
PsiBlast_PDB
74.00
44%
-73
- C4 -
1MW9
9
TOP1_ECOLI
X:
[2-589]
-
G
K
A
L
V
I
V
E
S
P
A
K
A
K
T
I
N
K
Y
L
G
S
D
Y
V
V
K
S
S
V
G
H
I
R
D
L
P
T
-ERGALVN-------
R
--------------
M
-----------
G
-----
V
-----
D
P
W
H
N
W
E
A
H
Y
E
V
L
P
G
K
E
K
V
V
S
E
L
K
Q
L
A
E
K
A
D
H
I
Y
L
A
T
D
L
D
R
E
G
E
A
I
A
W
H
L
R
E
V
I
G
G
D
D
A
R
Y
S
R
V
V
F
N
E
I
T
K
N
A
I
R
Q
A
F
N
K
P
G
E
L
N
I
D
R
V
N
A
Q
Q
A
R
R
F
M
D
R
V
V
G
Y
M
V
S
P
L
L
W
K
K
I
A
R
G
L
S
A
G
R
V
Q
S
V
A
V
R
L
V
V
E
R
E
R
E
I
K
A
F
V
P
E
E
F
W
E
V
----
D
A
S
T
T
T
---
P
S
G
-------
E
-
A
L
A
L
Q
V
T
H
Q
N
D
------------------
K
P
F
R
P
V
N
------------------
K
E
-
Q
T
Q
A
-------
A
V
S
L
L
E
K
-
A
R
Y
S
V
L
E
R
E
D
K
P
T
T
S
K
P
G
A
P
F
I
T
S
T
L
Q
Q
A
A
S
T
R
L
G
F
G
V
K
K
T
M
M
M
A
Q
R
L
Y
E
A
---------
G
Y
I
T
Y
M
R
T
D
S
T
N
L
S
Q
D
A
V
N
M
V
R
G
Y
I
S
D
N
F
G
K
K
Y
L
P
-
E
-
S
P
N
Q
Y
A
--------
R
E
A
I
R
P
S
D
-
V
N
-
V
M
A
E
S
L
K
---
D
M
E
---
A
-
D
A
Q
K
L
Y
Q
L
I
W
R
Q
F
V
A
C
Q
M
T
P
A
K
Y
D
S
T
T
L
T
V
G
----
A
G
----
D
F
R
L
K
A
R
G
R
I
L
--
R
--
F
D
G
W
T
K
V
M
P
A
L
---------------
E
D
R
I
L
P
A
V
N
K
G
D
A
L
T
L
V
E
L
T
P
A
Q
H
F
T
K
P
P
A
R
F
S
E
A
S
L
V
K
E
L
E
K
R
G
I
G
R
P
S
T
Y
A
S
I
I
S
T
I
Q
D
R
G
Y
V
R
V
E
N
R
R
F
Y
A
E
K
M
G
E
I
V
T
D
R
L
E
E
N
F
R
E
L
M
N
Y
D
F
T
A
Q
M
E
N
N
L
D
Q
V
A
N
H
E
A
E
W
K
A
V
L
D
H
F
F
S
D
F
T
Q
Q
L
D
K
A
E
K
D
P
E
---
E
---
G
----
G
---
M
R
----
P
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
7
PsiBlast_PDB
73.98
44%
-80
- C4 -
1CY4
4
TOP1_ECOLI
A:
[4-591]
-
G
K
A
L
V
I
V
E
S
P
A
K
A
K
T
I
N
K
Y
L
G
S
D
Y
V
V
K
S
S
V
G
H
I
R
D
L
P
T
-DER
G
A
L
V
N
------
R
--------------
M
-----------
G
-----
V
-----
D
P
W
H
N
W
E
A
H
Y
E
V
L
P
G
K
E
K
V
V
S
E
L
K
Q
L
A
E
K
A
D
H
I
Y
L
A
T
D
L
D
R
E
G
E
A
I
A
W
H
L
R
E
V
I
G
G
D
D
A
R
Y
S
R
V
V
F
N
E
I
T
K
N
A
I
R
Q
A
F
N
K
P
G
E
L
N
I
D
R
V
N
A
Q
Q
A
R
R
F
M
D
R
V
V
G
Y
M
V
S
P
L
L
W
K
K
I
A
R
G
L
S
A
G
R
V
Q
S
V
A
V
R
L
V
V
E
R
E
R
E
I
K
A
F
V
P
E
E
F
W
E
V
----
D
A
S
T
T
T
---
P
S
G
-------
E
-
A
L
A
L
Q
V
T
H
Q
N
D
------------------
K
P
F
R
P
V
N
------------------
K
E
-
Q
T
Q
A
-------
A
V
S
L
L
E
K
-
A
R
Y
S
V
L
E
R
E
D
K
P
T
T
S
K
P
G
A
P
F
I
T
S
T
L
Q
Q
A
A
S
T
R
L
G
F
G
V
K
K
T
M
M
M
A
Q
R
L
Y
E
A
---------
G
Y
I
T
Y
M
R
T
D
S
T
N
L
S
Q
D
A
V
N
M
V
R
G
Y
I
S
D
N
F
G
K
K
Y
L
P
-
E
-
S
P
N
Q
Y
A
--------
H
E
A
I
R
P
S
D
-
V
N
-
V
M
A
E
S
L
K
---
D
-
M
---
E
A
D
A
Q
K
L
Y
Q
L
I
W
R
Q
F
V
A
C
Q
M
T
P
A
K
Y
D
S
T
T
L
T
V
G
----
A
G
----
D
F
R
L
K
A
R
G
R
I
L
--
R
--
F
D
G
W
T
K
V
M
P
A
L
------------------
I
L
P
A
V
N
K
G
D
A
L
T
L
V
E
L
T
P
A
Q
H
F
T
K
P
P
A
R
F
S
E
A
S
L
V
K
E
L
E
K
R
G
I
G
R
P
S
T
Y
A
S
I
I
S
T
I
Q
D
R
G
Y
V
R
V
E
N
R
R
F
Y
A
E
K
M
G
E
I
V
T
D
R
L
E
E
N
F
R
E
L
M
N
Y
D
F
T
A
Q
M
E
N
S
L
D
Q
V
A
N
H
E
A
E
W
K
A
V
L
D
H
F
F
S
D
F
T
Q
Q
L
D
K
A
E
K
D
P
E
---
E
---
G
----
G
---
M
R
----
P
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
5
PsiBlast_PDB
73.89
44%
-76
- C4 -
1CY8
3
TOP1_ECOLI
A:
[4-591]
-
G
K
A
L
V
I
V
E
S
P
A
K
A
K
T
I
N
K
Y
L
G
S
D
Y
V
V
K
S
S
V
G
H
I
R
D
L
P
--DER
G
A
L
V
N
------
R
--------------
M
-----------
G
-----
V
-----
D
P
W
H
N
W
E
A
H
Y
E
V
L
P
G
K
E
K
V
V
S
E
L
K
Q
L
A
E
K
A
D
H
I
Y
L
A
T
D
L
D
R
E
G
E
A
I
A
W
H
L
R
E
V
I
G
G
D
D
A
R
Y
S
R
V
V
F
N
E
I
T
K
N
A
I
R
Q
A
F
N
K
P
G
E
L
N
I
D
R
V
N
A
Q
Q
A
R
R
F
M
D
R
V
V
G
Y
M
V
S
P
L
L
W
K
K
I
A
R
G
L
S
A
G
R
V
Q
S
V
A
V
R
L
V
V
E
R
E
R
E
I
K
A
F
V
P
E
E
F
W
E
V
----
D
A
S
T
T
T
---
P
S
G
-------
E
-
A
L
A
L
Q
V
T
H
Q
N
D
------------------
K
P
F
R
P
V
N
------------------
K
E
-
Q
T
Q
A
-------
A
V
S
L
L
E
K
-
A
R
Y
S
V
L
E
R
E
D
K
P
T
T
S
K
P
G
A
P
F
I
T
S
T
L
Q
Q
A
A
S
T
R
L
G
F
G
V
K
K
T
M
M
M
A
Q
R
L
Y
E
A
---------
G
Y
I
T
Y
M
R
T
D
S
T
N
L
S
Q
D
A
V
N
M
V
R
G
Y
I
S
D
N
F
G
K
K
Y
L
P
-
E
-
S
P
N
Q
Y
A
--------
H
E
A
I
R
P
S
D
-
V
N
-
V
M
A
E
S
L
K
---
D
-
M
---
E
A
D
A
Q
K
L
Y
Q
L
I
W
R
Q
F
V
A
C
Q
M
T
P
A
K
Y
D
S
T
T
L
T
V
G
----
A
G
----
D
F
R
L
K
A
R
G
R
I
L
--
R
--
F
D
G
W
T
K
V
M
P
A
L
R
K
G
-----------
D
E
D
R
I
L
P
A
V
N
K
G
D
A
L
T
L
V
E
L
T
P
A
Q
H
F
T
K
P
P
A
R
F
S
E
A
S
L
V
K
E
L
E
K
R
G
I
G
R
P
S
T
Y
A
S
I
I
S
T
I
Q
D
R
G
Y
V
R
V
E
N
R
R
F
Y
A
E
K
M
G
E
I
V
T
D
R
L
E
E
N
F
R
E
L
M
N
Y
D
F
T
A
Q
M
E
N
S
L
D
Q
V
A
N
H
E
A
E
W
K
A
V
L
D
H
F
F
S
D
F
T
Q
Q
L
D
K
A
E
K
D
P
E
---
E
---
G
----
G
---
M
R
----
P
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
8
PsiBlast_PDB
73.81
44%
-77
- C4 -
3PWT
3
TOP1_ECOLI
A:
[2-589]
-
G
K
A
L
V
I
V
E
S
P
A
K
A
K
T
I
N
K
Y
L
G
S
D
Y
V
V
K
S
S
V
G
H
I
R
D
L
P
T
-DER
G
A
L
V
N
------
R
--------------
M
-----------
G
-----
V
-----
D
P
W
H
N
W
E
A
H
Y
E
V
L
P
G
K
E
K
V
V
S
E
L
K
Q
L
A
E
K
A
D
H
I
Y
L
A
T
N
L
D
R
E
G
E
A
I
A
W
H
L
R
E
V
I
G
G
D
D
A
R
Y
S
R
V
V
F
N
E
I
T
K
N
A
I
R
Q
A
F
N
K
P
G
E
L
N
I
D
R
V
N
A
Q
Q
A
R
R
F
M
D
R
V
V
G
Y
M
V
S
P
L
L
W
K
K
I
A
R
G
L
S
A
G
R
V
Q
S
V
A
V
R
L
V
V
E
R
E
R
E
I
K
A
F
V
P
E
E
F
W
E
V
----
D
A
S
T
T
T
---
P
S
G
-------
E
-
A
L
A
L
Q
V
T
H
Q
N
D
------------------
K
P
F
R
P
V
N
------------------
K
E
-
Q
T
Q
A
-------
A
V
S
L
L
E
K
-
A
R
Y
S
V
L
E
R
E
D
K
P
T
T
S
K
P
G
A
P
F
I
T
S
T
L
Q
Q
A
A
S
T
R
L
G
F
G
V
K
K
T
M
M
M
A
Q
R
L
Y
E
A
---------
G
Y
I
T
Y
M
R
T
D
S
T
N
L
S
Q
D
A
V
N
M
V
R
G
Y
I
S
D
N
F
G
K
K
Y
L
P
-
E
-
S
P
N
Q
Y
A
-------
A
H
E
A
I
R
P
S
D
-
V
N
-
V
M
A
E
S
L
K
---
D
-
M
---
E
A
D
A
Q
K
L
Y
Q
L
I
W
R
Q
F
V
A
C
Q
M
T
P
A
K
Y
D
S
T
T
L
T
V
G
----
A
G
----
D
F
R
L
K
A
R
G
R
I
L
--
R
--
F
D
G
W
T
K
V
M
P
A
L
R
--------------
E
D
R
I
L
P
A
V
N
K
G
D
A
L
T
L
V
E
L
T
P
A
Q
H
F
T
K
P
P
A
R
F
S
E
A
S
L
V
K
E
L
E
K
R
G
I
G
R
P
S
T
Y
A
S
I
I
S
T
I
Q
D
R
G
Y
V
R
V
E
N
R
R
F
Y
A
E
K
M
G
E
I
V
T
D
R
L
E
E
N
F
R
E
L
M
N
Y
D
F
T
A
Q
M
E
N
S
L
D
Q
V
A
N
H
E
A
E
W
K
A
V
L
D
H
F
F
S
D
F
T
Q
Q
L
D
K
A
E
K
D
P
E
---
E
---
G
----
G
---
M
R
----
P
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
2
PsiBlast_PDB
73.44
44%
-77
- C4 -
1CY1
4
TOP1_ECOLI
A:
[4-591]
-
G
K
A
L
V
I
V
E
S
P
A
K
A
K
T
I
N
K
Y
L
G
S
D
Y
V
V
K
S
S
V
G
H
I
R
D
L
P
--R
G
A
L
V
N
--------
R
--------------
M
-----------
G
-----
V
-----
D
P
W
H
N
W
E
A
H
Y
E
V
L
P
G
K
E
K
V
V
S
E
L
K
Q
L
A
E
K
A
D
H
I
Y
L
A
T
D
L
D
R
E
G
E
A
I
A
W
H
L
R
E
V
I
G
G
D
D
A
R
Y
S
R
V
V
F
N
E
I
T
K
N
A
I
R
Q
A
F
N
K
P
G
E
L
N
I
D
R
V
N
A
Q
Q
A
R
R
F
M
D
R
V
V
G
Y
M
V
S
P
L
L
W
K
K
I
A
R
G
L
S
A
G
R
V
Q
S
V
A
V
R
L
V
V
E
R
E
R
E
I
K
A
F
V
P
E
E
F
W
E
V
----
D
A
S
T
T
T
---
P
S
G
-------
E
-
A
L
A
L
Q
V
T
H
Q
N
D
------------------
K
P
F
R
P
V
N
------------------
K
E
-
Q
T
Q
A
-------
A
V
S
L
L
E
K
-
A
R
Y
S
V
L
E
R
E
D
K
P
T
T
S
K
P
G
A
P
F
I
T
S
T
L
Q
Q
A
A
S
T
R
L
G
F
G
V
K
K
T
M
M
M
A
Q
R
L
Y
E
A
---------
G
Y
I
T
Y
M
R
T
D
S
T
N
L
S
Q
D
A
V
N
M
V
R
G
Y
I
S
D
N
F
G
K
K
Y
L
P
-
E
-
S
P
N
Q
Y
A
------
E
A
H
E
A
I
R
P
S
D
-
V
N
-
V
M
A
E
S
L
K
---
D
-
M
---
E
A
D
A
Q
K
L
Y
Q
L
I
W
R
Q
F
V
A
C
Q
M
T
P
A
K
Y
D
S
T
T
L
T
V
G
----
A
G
----
D
F
R
L
K
A
R
G
R
I
L
--
R
--
F
D
G
W
T
K
V
M
P
A
L
------------------
I
L
P
A
V
N
K
G
D
A
L
T
L
V
E
L
T
P
A
Q
H
F
T
K
P
P
A
R
F
S
E
A
S
L
V
K
E
L
E
K
R
G
I
G
R
P
S
T
Y
A
S
I
I
S
T
I
Q
D
R
G
Y
V
R
V
E
N
R
R
F
Y
A
E
K
M
G
E
I
V
T
D
R
L
E
E
N
F
R
E
L
M
N
Y
D
F
T
A
Q
M
E
N
S
L
D
Q
V
A
N
H
E
A
E
W
K
A
V
L
D
H
F
F
S
D
F
T
Q
Q
L
D
K
A
E
K
D
P
E
---
E
---
G
----
G
---
M
R
----
P
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
9
PsiBlast_PDB
73.17
44%
-75
- C4 -
1ECL
-
TOP1_ECOLI
A:
[2-589]
-
G
K
A
L
V
I
V
E
S
P
A
K
A
K
T
I
N
K
Y
L
G
S
D
Y
V
V
K
S
S
V
G
H
I
R
D
L
P
--DER
G
A
L
V
N
------
R
--------------
M
-----------
G
-----
V
-----
D
P
W
H
N
W
E
A
H
Y
E
V
L
P
G
K
E
K
V
V
S
E
L
K
Q
L
A
E
K
A
D
H
I
Y
L
A
T
D
L
D
R
E
G
E
A
I
A
W
H
L
R
E
V
I
G
G
D
D
A
R
Y
S
R
V
V
F
N
E
I
T
K
N
A
I
R
Q
A
F
N
K
P
G
E
L
N
I
D
R
V
N
A
Q
Q
A
R
R
F
M
D
R
V
V
G
Y
M
V
S
P
L
L
W
K
K
I
A
R
G
L
S
A
G
R
V
Q
S
V
A
V
R
L
V
V
E
R
E
R
E
I
K
A
F
V
P
E
E
F
W
E
V
----
D
A
S
T
T
T
---
P
S
G
-------
E
-
A
L
A
L
Q
V
T
H
Q
N
D
------------------
K
P
F
R
P
V
N
------------------
K
E
-
Q
T
Q
A
-------
A
V
S
L
L
E
K
-
A
R
Y
S
V
L
E
R
E
D
K
P
T
T
S
K
P
G
A
P
F
I
T
S
T
L
Q
Q
A
A
S
T
R
L
G
F
G
V
K
K
T
M
M
M
A
Q
R
L
Y
E
A
---------
G
Y
I
T
Y
M
R
T
D
S
T
N
L
S
Q
D
A
V
N
M
V
R
G
Y
I
S
D
N
F
G
K
K
Y
L
P
-
E
-
S
P
N
Q
Y
A
--------
H
E
A
I
R
P
S
D
-
V
N
-
V
M
A
E
S
L
K
---
D
-
M
---
E
A
D
A
Q
K
L
Y
Q
L
I
W
R
Q
F
V
A
C
Q
M
T
P
A
K
Y
D
S
T
T
L
T
V
G
----
A
G
----
D
F
R
L
K
A
R
G
R
I
L
--
R
--
F
D
G
W
T
K
V
M
P
A
L
R
-----------------
I
L
P
A
V
N
K
G
D
A
L
T
L
V
E
L
T
P
A
Q
H
F
T
K
P
P
A
R
F
S
E
A
S
L
V
K
E
L
E
K
R
G
I
G
R
P
S
T
Y
A
S
I
I
S
T
I
Q
D
R
G
Y
V
R
V
E
N
R
R
F
Y
A
E
K
M
G
E
I
V
T
D
R
L
E
E
N
F
R
E
L
M
N
Y
D
F
T
A
Q
M
E
N
S
L
D
Q
V
A
N
H
E
A
E
W
K
A
V
L
D
H
F
F
S
D
F
T
Q
Q
L
D
K
A
E
K
D
P
E
---
E
---
G
----
G
---
M
R
----
P
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
3
PsiBlast_PDB
72.86
44%
-75
- C4 -
1CY2
3
TOP1_ECOLI
A:
[4-591]
-
G
K
A
L
V
I
V
E
S
P
A
K
A
K
T
I
N
K
Y
L
G
S
D
Y
V
V
K
S
S
V
G
H
I
R
D
L
P
--DER
G
A
L
V
N
------
R
--------------
M
-----------
G
-----
V
-----
D
P
W
H
N
W
E
A
H
Y
E
V
L
P
G
K
E
K
V
V
S
E
L
K
Q
L
A
E
K
A
D
H
I
Y
L
A
T
D
L
D
R
E
G
E
A
I
A
W
H
L
R
E
V
I
G
G
D
D
A
R
Y
S
R
V
V
F
N
E
I
T
K
N
A
I
R
Q
A
F
N
K
P
G
E
L
N
I
D
R
V
N
A
Q
Q
A
R
R
F
M
D
R
V
V
G
Y
M
V
S
P
L
L
W
K
K
I
A
R
G
L
S
A
G
R
V
Q
S
V
A
V
R
L
V
V
E
R
E
R
E
I
K
A
F
V
P
E
E
F
W
E
V
----
D
A
S
T
T
T
---
P
S
G
-------
E
-
A
L
A
L
Q
V
T
H
Q
N
D
------------------
K
P
F
R
P
V
N
------------------
K
E
-
Q
T
Q
A
-------
A
V
S
L
L
E
K
-
A
R
Y
S
V
L
E
R
E
D
K
P
T
T
S
K
P
G
A
P
F
I
T
S
T
L
Q
Q
A
A
S
T
R
L
G
F
G
V
K
K
T
M
M
M
A
Q
R
L
Y
E
A
---------
G
Y
I
T
Y
M
R
T
D
S
T
N
L
S
Q
D
A
V
N
M
V
R
G
Y
I
S
D
N
F
G
K
K
Y
L
P
-
E
-
S
P
N
Q
Y
A
-------
A
H
E
A
I
R
P
S
D
-
V
N
-
V
M
A
E
S
L
K
---
D
-
M
---
E
A
D
A
Q
K
L
Y
Q
L
I
W
R
Q
F
V
A
C
Q
M
T
P
A
K
Y
D
S
T
T
L
T
V
G
----
A
G
----
D
F
R
L
K
A
R
G
R
I
L
--
R
--
F
D
G
W
T
K
V
M
P
A
L
R
-----------------
I
L
P
A
V
N
K
G
D
A
L
T
L
V
E
L
T
P
A
Q
H
F
T
K
P
P
A
R
F
S
E
A
S
L
V
K
E
L
E
K
R
G
I
G
R
P
S
T
Y
A
S
I
I
S
T
I
Q
D
R
G
Y
V
R
V
E
N
R
R
F
Y
A
E
K
M
G
E
I
V
T
D
R
L
E
E
N
F
R
E
L
M
N
Y
D
F
T
A
Q
M
E
N
S
L
D
Q
V
A
N
H
E
A
E
W
K
A
V
L
D
H
F
F
S
D
F
T
Q
Q
L
D
K
A
E
K
D
P
E
---
E
---
G
----
G
---
M
R
----
P
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
15
PsiBlast_PDB
72.39
41%
-58
- C4 -
5D5H
8
TOP1_MYCTU
A:
[22-610]
----
L
V
I
V
E
S
P
T
K
A
R
K
L
A
S
Y
L
G
S
G
Y
I
V
E
S
S
R
G
H
I
R
D
L
P
R
A
ASDVPAKYKSQPWA
R
--------------
L
-----------
G
-----
V
-----
N
V
D
A
D
F
E
P
L
Y
I
I
S
P
E
K
R
S
T
V
S
E
L
R
G
L
L
K
D
V
D
E
L
Y
L
A
T
D
G
D
R
E
G
E
A
I
A
W
H
L
L
E
T
L
K
P
R
I
P
V
K
-
R
M
V
F
H
E
I
T
E
P
A
I
R
A
A
A
E
H
P
R
D
L
D
I
D
L
V
D
A
Q
E
T
R
R
I
L
D
R
L
Y
G
Y
E
V
S
P
V
L
W
K
K
V
A
P
K
L
S
A
G
R
V
Q
S
V
A
T
R
I
I
V
A
R
E
R
D
R
M
A
F
R
S
A
A
Y
W
D
I
L
A
K
L
D
A
-
S
V
S
DPD
A
A
P
-------
P
-
T
F
S
A
R
L
T
A
V
A
G
------------------
R
R
V
-
A
T
G
RDFDSLGTLRKG
D
E
V
I
V
L
D
E
G
S
A
T
A
-------
L
A
A
G
L
D
G
-
T
Q
L
T
V
A
S
A
E
E
K
P
Y
A
R
R
P
Y
P
P
F
M
T
S
T
L
Q
Q
E
A
S
R
K
L
R
F
S
A
E
R
T
M
S
I
A
Q
R
L
Y
E
N
---------
G
Y
I
T
Y
M
R
T
D
S
T
T
L
S
E
S
A
I
N
A
A
R
T
Q
A
R
Q
L
Y
G
D
E
Y
V
A
P
A
-
P
R
Q
Y
T
R
K
V
K
N
A
Q
E
A
H
E
A
I
R
P
A
G
E
T
F
-
A
T
P
D
A
V
R
---
R
E
L
DGP
N
I
D
D
F
R
L
Y
E
L
I
W
Q
R
T
V
A
S
Q
M
A
D
A
R
G
M
T
L
S
L
R
I
T
G
M
SG
H
Q
----
E
V
V
F
S
A
T
G
R
T
L
--
T
--
F
P
G
F
L
K
A
Y
V
E
T
V
D
E
LV
G
G
E
----
A
D
D
A
E
R
R
L
P
H
L
T
P
G
Q
R
L
D
I
V
E
L
T
P
D
G
H
A
T
N
P
P
A
R
Y
T
E
A
S
L
V
K
A
L
E
E
L
G
I
G
R
P
S
T
Y
S
S
I
I
K
T
I
Q
D
R
G
Y
V
H
K
K
G
S
A
L
V
P
S
W
V
A
F
A
V
T
G
L
L
E
Q
H
F
G
R
L
V
D
Y
D
F
T
A
A
M
E
D
E
L
D
E
I
A
A
G
N
E
R
R
T
N
W
L
N
N
F
Y
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
14
PsiBlast_PDB
71.79
42%
-77
- C4 -
2GAJ
-
TOP1_THEMA
A:
[9-586]
-----
I
V
V
E
S
P
A
K
A
K
T
I
K
S
I
L
G
N
E
Y
E
V
F
A
S
M
G
H
I
I
D
L
P
K
S
--------------
K
--------------
F
-----------
G
-----
V
-----
D
L
E
K
D
F
E
P
E
F
A
V
I
K
G
K
E
K
V
V
E
K
L
K
D
L
A
K
K
G
E
-
L
L
I
A
S
D
M
D
R
E
G
E
A
I
A
W
H
I
A
R
V
T
N
T
-
L
G
R
K
N
R
I
V
F
S
E
I
T
P
R
V
I
R
E
A
V
K
N
P
R
E
I
D
M
K
K
V
R
A
Q
L
A
R
R
I
L
D
R
I
V
G
Y
S
L
S
P
V
L
W
R
N
F
K
S
N
L
S
A
G
R
V
Q
S
A
T
L
K
L
V
C
D
R
E
R
E
I
L
R
F
V
P
K
K
Y
H
R
I
----
T
V
-
N
F
-------------------------
D
G
-----------------------
L
T
------------------
A
E
I
D
V
K
E
KKFFD
A
E
T
L
K
E
I
Q
S
I
D
E
L
V
V
E
E
K
K
V
S
V
K
K
F
A
P
P
E
P
F
K
T
S
T
L
Q
Q
E
A
Y
S
K
L
G
F
S
V
S
K
T
M
M
I
A
Q
Q
L
Y
E
G
V
E
T
-
K
D
G
H
I
A
F
I
T
Y
M
R
T
D
S
T
R
V
S
D
Y
A
K
E
E
A
R
N
L
I
T
E
V
F
G
E
E
Y
V
G
----------------
A
H
E
A
I
R
P
T
N
-
V
F
-
M
T
P
E
E
A
G
---
K
Y
L
---
N
S
D
Q
K
K
L
Y
E
L
I
W
K
R
F
L
A
S
Q
M
K
P
S
Q
Y
E
E
T
R
F
V
L
R
----
T
K
----
D
G
K
Y
R
F
K
G
T
V
L
--
K
K
I
F
D
G
Y
E
K
V
W
----------
K
----
T
E
R
N
T
G
E
F
P
-
F
E
E
G
E
S
V
K
P
V
V
V
K
I
E
E
Q
E
T
K
P
K
P
R
Y
T
E
G
S
L
V
K
E
M
E
R
L
G
I
G
R
P
S
T
Y
A
S
T
I
K
L
L
L
N
R
G
Y
I
K
K
I
R
G
Y
L
Y
P
T
I
V
G
S
V
V
M
D
Y
L
E
K
K
Y
S
D
V
V
S
V
S
F
T
A
E
M
E
K
D
L
D
E
V
E
Q
G
K
K
T
D
K
I
V
L
R
E
F
Y
E
S
F
S
S
V
F
D
R
N
D
R
I
V
V
---
D
---
F
----
P
---------------
T
N
Q
K
C
S
-
C
G
K
E
M
R
L
S
F
G
K
Y
G
F
Y
L
K
C
---------
E
C
G
K
T
R
S
V
-------------------------------------------------------------------------------------------------------------------------------------------
6
PsiBlast_PDB
71.58
44%
-75
- C4 -
1CY0
1
TOP1_ECOLI
A:
[4-574]
-
G
K
A
L
V
I
V
E
S
P
A
K
A
K
T
I
N
K
Y
L
G
S
D
Y
V
V
K
S
S
V
G
H
I
R
D
L
P
--A
L
V
N
----------
R
--------------
M
-----------
G
-----
V
-----
D
P
W
H
N
W
E
A
H
Y
E
V
L
P
G
K
E
K
V
V
S
E
L
K
Q
L
A
E
K
A
D
H
I
Y
L
A
T
D
L
D
R
E
G
E
A
I
A
W
H
L
R
E
V
I
G
G
D
D
A
R
Y
S
R
V
V
F
N
E
I
T
K
N
A
I
R
Q
A
F
N
K
P
G
E
L
N
I
D
R
V
N
A
Q
Q
A
R
R
F
M
D
R
V
V
G
Y
M
V
S
P
L
L
W
K
K
I
A
R
G
L
S
A
G
R
V
Q
S
V
A
V
R
L
V
V
E
R
E
R
E
I
K
A
F
V
P
E
E
F
W
E
V
----
D
A
S
T
T
T
---
P
S
G
-------
E
-
A
L
A
L
Q
V
T
H
Q
N
D
------------------
K
P
F
R
P
V
N
------------------
K
E
-
Q
T
Q
A
-------
A
V
S
L
L
E
K
-
A
R
Y
S
V
L
E
R
E
D
K
P
T
T
S
K
P
G
A
P
F
I
T
S
T
L
Q
Q
A
A
S
T
R
L
G
F
G
V
K
K
T
M
M
M
A
Q
R
L
Y
E
A
---------
G
Y
I
T
Y
M
R
T
D
S
T
N
L
S
Q
D
A
V
N
M
V
R
G
Y
I
S
D
N
F
G
K
K
Y
L
P
-
E
-
S
P
N
Q
Y
A
S
K
E
N
S
Q
E
A
H
E
A
I
R
P
S
D
-
V
N
-
V
M
A
E
S
L
K
---
D
-
M
---
E
A
D
A
Q
K
L
Y
Q
L
I
W
R
Q
F
V
A
C
Q
M
T
P
A
K
Y
D
S
T
T
L
T
V
G
----
A
G
----
D
F
R
L
K
A
R
G
R
I
L
--
R
--
F
D
G
W
T
K
V
M
---------------------
I
L
P
A
V
N
K
G
D
A
L
T
L
V
E
L
T
P
A
Q
H
F
T
K
P
P
A
R
F
S
E
A
S
L
V
K
E
L
E
K
R
G
I
G
R
P
S
T
Y
A
S
I
I
S
T
I
Q
D
R
G
Y
V
R
V
E
N
R
R
F
Y
A
E
K
M
G
E
I
V
T
D
R
L
E
E
N
F
R
E
L
M
N
Y
D
F
T
A
Q
M
E
N
S
L
D
Q
V
A
N
H
E
A
E
W
K
A
V
L
D
H
F
F
S
D
F
T
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
26
HHSearch
69.15
42%
-72
- C- -
2GAI
-
TOP1_THEMA
A:
[7-601]
---
K
Y
I
V
V
E
S
P
A
K
A
K
T
I
K
S
I
L
G
N
E
Y
E
V
F
A
S
M
G
H
I
I
D
L
P
K
S
--------------
K
--------------
F
-----------
G
-----
V
-----
D
L
E
K
D
F
E
P
E
F
A
V
I
K
G
K
E
K
V
V
E
K
L
K
D
L
A
K
K
-
G
E
L
L
I
A
S
D
M
D
R
E
G
E
A
I
A
W
H
I
A
R
V
T
N
T
L
-
G
R
K
N
R
I
V
F
S
E
I
T
P
R
V
I
R
E
A
V
K
N
P
R
E
I
D
M
K
K
V
R
A
Q
L
A
R
R
I
L
D
R
I
V
G
Y
S
L
S
P
V
L
W
R
N
F
K
S
N
L
S
A
G
R
V
Q
S
A
T
L
K
L
V
C
D
R
E
R
E
I
L
R
F
V
P
K
K
Y
H
R
I
----
T
V
-
N
F
D
---
G
L
T
-------
A
-
E
I
D
----
V
---------------------
K
E
K
-
K
F
F
------------------
D
A
E
T
L
K
E
-------
I
Q
S
I
----
D
E
L
V
V
E
E
K
K
V
S
V
K
K
F
A
P
P
E
P
F
K
T
S
T
L
Q
Q
E
A
Y
S
K
L
G
F
S
V
S
K
T
M
M
I
A
Q
Q
L
Y
E
G
V
E
T
K
D
G
H
-
I
A
F
I
T
Y
M
R
T
D
S
T
R
V
S
D
Y
A
K
E
E
A
R
N
L
I
T
E
V
F
G
E
E
Y
V
G
----------------
A
H
E
A
I
R
P
T
N
-
V
F
-
M
T
P
E
E
A
G
---
K
Y
L
---
N
S
D
Q
K
K
L
Y
E
L
I
W
K
R
F
L
A
S
Q
M
K
P
S
Q
Y
E
E
T
R
F
V
L
R
----
T
K
----
D
G
K
Y
R
F
K
G
T
V
L
K
K
I
--
F
D
G
Y
E
K
V
W
K
T
E
R
---------------
N
T
G
E
F
P
F
E
E
G
E
S
V
K
P
V
V
V
K
I
E
E
Q
E
T
K
P
K
P
R
Y
T
E
G
S
L
V
K
E
M
E
R
L
G
I
G
R
P
S
T
Y
A
S
T
I
K
L
L
L
N
R
G
Y
I
K
K
I
R
G
Y
L
Y
P
T
I
V
G
S
V
V
M
D
Y
L
E
K
K
Y
S
D
V
V
S
V
S
F
T
A
E
M
E
K
D
L
D
E
V
E
Q
G
K
K
T
D
K
I
V
L
R
E
F
Y
E
S
F
S
S
V
F
D
R
N
D
R
I
V
-----------------
V
D
----
F
P
---
T
N
Q
-
K
C
S
-
C
G
K
E
M
R
L
S
F
G
K
Y
G
F
Y
L
K
C
E
---------
C
G
K
T
R
S
V
K
N
---------------------------------------------
D
E
I
A
-
V
---
I
D
D
G
K
I
F
L
---------------------------------------------------------------------------
13
PsiBlast_PDB
69.12
42%
-78
- C- -
2GAI
-
TOP1_THEMA
A:
[9-586]
-----
I
V
V
E
S
P
A
K
A
K
T
I
K
S
I
L
G
N
E
Y
E
V
F
A
S
M
G
H
I
I
D
L
P
K
S
--------------
K
--------------
F
-----------
G
-----
V
-----
D
L
E
K
D
F
E
P
E
F
A
V
I
K
G
K
E
K
V
V
E
K
L
K
D
L
A
K
K
G
E
-
L
L
I
A
S
D
M
D
R
E
G
E
A
I
A
W
H
I
A
R
V
T
N
T
-
L
G
R
K
N
R
I
V
F
S
E
I
T
P
R
V
I
R
E
A
V
K
N
P
R
E
I
D
M
K
K
V
R
A
Q
L
A
R
R
I
L
D
R
I
V
G
Y
S
L
S
P
V
L
W
R
N
F
K
S
N
L
S
A
G
R
V
Q
S
A
T
L
K
L
V
C
D
R
E
R
E
I
L
R
F
V
P
K
K
Y
H
R
I
----
T
V
-
N
F
-------------------------
D
G
-----------------------
L
T
------------------
A
E
I
D
V
K
E
K
K
F
F
D
A
E
T
L
K
E
I
Q
S
I
D
E
L
V
V
E
E
K
K
V
S
V
K
K
F
A
P
P
E
P
F
K
T
S
T
L
Q
Q
E
A
Y
S
K
L
G
F
S
V
S
K
T
M
M
I
A
Q
Q
L
Y
E
G
V
E
T
-
K
D
G
H
I
A
F
I
T
Y
M
R
T
D
S
T
R
V
S
D
Y
A
K
E
E
A
R
N
L
I
T
E
V
F
G
E
E
Y
V
G
----------------
A
H
E
A
I
R
P
T
N
-
V
F
-
M
T
P
E
E
A
G
---
K
Y
L
---
N
S
D
Q
K
K
L
Y
E
L
I
W
K
R
F
L
A
S
Q
M
K
P
S
Q
Y
E
E
T
R
F
V
L
R
----
T
K
----
D
G
K
Y
R
F
K
G
T
V
L
--
K
K
I
F
D
G
Y
E
K
V
W
----------
K
----
T
E
R
N
T
G
E
F
P
-
F
E
E
G
E
S
V
K
P
V
V
V
K
I
E
E
Q
E
T
K
P
K
P
R
Y
T
E
G
S
L
V
K
E
M
E
R
L
G
I
G
R
P
S
T
Y
A
S
T
I
K
L
L
L
N
R
G
Y
I
K
K
I
R
G
Y
L
Y
P
T
I
V
G
S
V
V
M
D
Y
L
E
K
K
Y
S
D
V
V
S
V
S
F
T
A
E
M
E
K
D
L
D
E
V
E
Q
G
K
K
T
D
K
I
V
L
R
E
F
Y
E
S
F
S
S
V
F
D
R
N
D
R
I
V
V
---
D
---
F
----
P
---------------
T
N
Q
K
C
S
-
C
G
K
E
M
R
L
S
F
G
K
Y
G
F
Y
L
K
C
---------
E
C
G
K
T
R
S
V
-------------------------------------------------------------------------------------------------------------------------------------------
47
Fugue
68.83
42%
-70
- C- -
2GAI
-
TOP1_THEMA
A:
[7-601]
---
K
Y
I
V
V
E
S
P
A
K
A
K
T
I
K
S
I
L
G
N
E
Y
E
V
F
A
S
M
G
H
I
I
D
L
P
K
S
--------------
K
--------------
F
-----------
G
-----
V
-----
D
L
E
K
D
F
E
P
E
F
A
V
I
K
G
K
E
K
V
V
E
K
L
K
D
L
A
K
K
G
E
-
L
L
I
A
S
D
M
D
R
E
G
E
A
I
A
W
H
I
A
R
V
T
N
T
L
-
G
R
K
N
R
I
V
F
S
E
I
T
P
R
V
I
R
E
A
V
K
N
P
R
E
I
D
M
K
K
V
R
A
Q
L
A
R
R
I
L
D
R
I
V
G
Y
S
L
S
P
V
L
W
R
N
F
K
S
N
L
S
A
G
R
V
Q
S
A
T
L
K
L
V
C
D
R
E
R
E
I
L
R
F
V
P
K
K
Y
H
R
I
----
T
V
-
N
F
------------------
D
G
L
T
A
E
I
D
V
------------------
K
E
K
-
K
F
F
------------------
D
A
E
T
L
K
E
-------
I
Q
---
S
I
-
D
E
L
V
V
E
E
K
K
V
S
V
K
K
F
A
P
P
E
P
F
K
T
S
T
L
Q
Q
E
A
Y
S
K
L
G
F
S
V
S
K
T
M
M
I
A
Q
Q
L
Y
E
G
V
E
T
K
-
D
G
H
I
A
F
I
T
Y
M
R
T
D
S
T
R
V
S
D
Y
A
K
E
E
A
R
N
L
I
T
E
V
F
G
E
E
Y
----------------
V
G
A
H
E
A
I
R
P
T
N
-
V
F
-
M
T
P
E
E
A
G
---
K
Y
L
---
N
S
D
Q
K
K
L
Y
E
L
I
W
K
R
F
L
A
S
Q
M
K
P
S
Q
Y
E
E
T
R
F
V
L
R
T
K--
D
G
----
K
Y
R
F
K
G
T
V
L
K
K
--
I
--
F
D
G
Y
E
K
V
W
K
T
E
R
N
T
----
G
-----------
E
F
P
F
E
E
G
E
S
V
K
P
V
V
V
K
I
E
E
Q
E
T
K
P
K
P
R
Y
T
E
G
S
L
V
K
E
M
E
R
L
G
I
G
R
P
S
T
Y
A
S
T
I
K
L
L
L
N
R
G
Y
I
K
K
I
R
G
Y
L
Y
P
T
I
V
G
S
V
V
M
D
Y
L
E
K
K
Y
S
D
V
V
S
V
S
F
T
A
E
M
E
K
D
L
D
E
V
E
Q
G
K
K
T
D
K
I
V
L
R
E
F
Y
E
S
F
S
S
V
F
D
R
N
D
R
I
V
-----------------------
V
D
---
F
P
T
N
Q
K
C
S
C
G
K
E
M
R
L
S
F
G
K
Y
G
F
Y
L
K
C
---------
E
C
G
K
T
R
S
V
K
N
------------------
D
---------------------
E
I
A
V
I
D
D
G
K
I
F
L
-------------------------------------------------------------------------------------