@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : bsu18620: (2016-06-30 )
MGIINGKEFIDRLNKLENEIWYDGEKIKGNISEHPAFKGIIKTKSSLYELQTKDELIHEMTYCLPGDHNRIGLSYLQPKTKNDLKKRRTMIEHWARHTHGMMGRSPDYMNTVMMSFASSAELLKDKENCFPEHILDMYEQAAKHDLSFTHTFITPQVNRSQSYFGLSEKPISAKVIDRTEKGLMIHGARLLATQGGLTDEILVFSAPKFFFETDEAYAFSIPSNTKGVKFITRESFVLSDSSFNHPLSSRYEEMDSIVVFDHVLVPWNRVFFYDNVEAAKDFMTKSSFHAFTFHQVVIRQMIKIEFLLGVAQLLVDTINVSEYQHIQEKLSEIIVGLETIKALIDKSENDAQLDEFGYMRPCLIPLQVISTIIPKLYPRFTEIIQLIGASGMVTLPTENAFDSEIREDLDQYLQATNTNAEERVKIFRLAWDLTMSSFGTRQTHYERYFFGDPIRISSRLYTSYPKQEQLNMIKTFLHADTEH
Atome Classification :
(20 SA)
.........10.....-...20........30........40........50........60........70...---...----..80........90......-..100...--.....110.......-----120..-----.-----..-----..130.......140.......150.......160.......170.......180.......190.....--..--200.......210.-.-..---...--.220.......230------.....----...----240---.......-.250--.......260.......270.......280...-..-..290.......300.......310.....---.--.320.......330.......340.......350.......360-.....-------...370.....-..380..-....-.390--..--.--....400..---------.---------.....410....-.-.-.----420.......430...--....440.......450.......460..----....---.470---.......480.
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MGII
N
G
K
E
F
I
D
R
L
N
K
L
-
E
N
E
IWYD
G
E
KIKGNISEHP
A
F
K
G
I
I
KTKSS
L
Y
ELQ
T
K
D
E
L
I
H
E
M
T
Y
CLPGDHNRI
G
L
S
---YLQ----PK
T
K
N
D
L
K
K
R
R
T
M
I
E
H
W
A
R
H
-THGM-MGR--S
P
D
Y
M
N
T
V
M
M
S
F
A
S
S
-----
A
E
L
L
K
-----
D
-----
K
E-----NC
F
P
E
H
I
L
D
M
Y
E
Q
A
A
KHDL
S
F
T
H
T
F
ITPQVNRSQSYFGLSEKPI
S
A
K
V
IDRTEK
G
L
M
I
HG
A
R
L
L
ATQGGL--T
D
--
E
I
L
V
FSAP
K
F
F
-
F
E-T-D
E
---
A
Y
A
--
F
SIPSNTK
G
V
K
F
I
-------
T
R
E
S
F
----
V
LS----DS----SFNH
P
L
S
-
S
R
Y
E
--
E
M
D
S
I
V
V
F
D
HVLVPW
N
R
V
F
F
YD
N
V
E
A
A
K
D
F
M
TK-SS-F
H
A
F
T
F
H
Q
V
V
I
R
Q
M
I
K
I
E
F
L
L
G
V
A
Q
L
L
V
D
T---I--
N
V
S
E
Y
Q
H
I
Q
E
K
L
S
E
I
I
V
G
L
E
T
I
K
A
L
IDKSENDA
Q
L
D
EFGYMRP--
C
L
I
P
L
-------
Q
V
I
S
T
I
I
P
K
L
Y
-
P
R
F
T
E
I
I
-
Q
L
IG-AS
G
M
--
V
T
--L--PTENA
F
-
D
S
---------
E
---------
I
R
E
D
L
D
Q
Y
L
Q
AT-N-T-
N
----
A
E
E
R
V
K
I
F
R
L
A
W
D
L
T
M
--
S
SFGTRQ
T
H
Y
E
R
Y
FFGD
P
I
R
I
S
S
R
L
YTSY----P
K
Q
E
---
Q
L
N
M
---
I
K
T
F
L
HADTEH
6
PsiBlast_PDB
86.54
41%
-45
- C6 -
2YYM
5
HPAB_THET8
A:
[4-469]
----
T
G
A
E
Y
I
E
A
L
K
T
R
-
P
P
N
L
W
Y
K
G
E
K
V
E
-
D
P
T
T
H
P
V
F
R
G
I
V
R
T
M
A
A
L
Y
D
L
Q
H
D
P
R
Y
R
E
V
L
T
Y
E
E
E
G
--
K
R
H
G
M
S
---
F
L
I
----
P
K
T
K
E
D
L
K
R
R
G
Q
A
Y
K
L
W
A
D
Q
-
N
L
G
M
-
M
G
R
--
S
P
D
Y
L
N
A
V
V
M
A
Y
A
A
S
-----
A
D
Y
F
G
-----
E
--------------
F
A
E
N
V
R
N
Y
Y
R
Y
L
R
D
Q
D
L
A
T
T
H
A
L
T
N
P
Q
V
N
R
A
R
P
P
S
G
Q
P
D
P
Y
I
P
V
G
V
V
K
Q
T
E
K
G
I
V
V
R
G
A
R
M
T
A
T
F
P
-
L
--
A
D
--
E
V
L
I
F
--
P
S
I
L
-
L
Q
-
A
-
G
S
EKY
A
L
A
--
F
A
L
P
T
S
T
P
G
L
H
F
V
-------
C
R
E
A
L
----
V
G
G
----
D
S
----
P
F
D
H
P
L
S
-
S
R
V
E
--
E
M
D
C
L
V
I
F
D
D
V
L
V
P
W
E
R
V
F
I
L
G
N
V
E
L
C
N
N
A
Y
G
A
-
T
G
-
A
L
N
H
M
A
H
Q
V
V
A
L
K
T
A
K
T
E
A
F
L
G
V
A
A
L
M
A
E
G
---
I
--
G
A
D
V
Y
G
H
V
Q
E
K
I
A
E
I
I
V
Y
L
E
A
M
R
A
F
W
T
R
A
E
E
E
A
K
E
N
A
Y
G
L
L
V
P
--
D
R
G
A
L
-------
D
G
A
R
N
L
Y
P
R
L
Y
-
P
R
I
R
E
I
L
-
E
Q
I
G
-
A
S
G
L
--
I
T
--
L
--
P
S
E
K
D
F
-
K
G
---------
P
---------
L
G
P
F
L
E
K
F
L
Q
G
A
-
A
-
L
-
E
----
A
K
E
R
V
A
L
F
R
L
A
W
D
M
T
L
--
S
G
F
G
A
R
Q
E
L
Y
E
R
F
F
F
G
D
P
V
R
M
Y
Q
T
L
Y
N
V
Y
----
N
K
E
P
---
Y
K
E
R
---
I
H
A
F
L
------
5
PsiBlast_PDB
86.02
41%
-48
- C6 -
2YYL
4
HPAB_THET8
A:
[4-469]
----
T
G
A
E
Y
I
E
A
L
K
T
R
-
P
P
N
L
W
Y
K
G
E
K
V
E
-
D
P
T
T
H
P
V
F
R
G
I
V
R
T
M
A
A
L
Y
D
L
Q
H
D
P
R
Y
R
E
V
L
T
Y
E
E
E
G
--
K
R
H
G
M
S
---
F
L
I
----
P
K
T
K
E
D
L
K
R
R
G
Q
A
Y
K
L
W
A
D
Q
-
N
L
G
M
-
M
G
R
--
S
P
D
Y
L
N
A
V
V
M
A
Y
A
A
S
-----
A
D
Y
F
G
-----
E
--------------
F
A
E
N
V
R
N
Y
Y
R
Y
L
R
D
Q
D
L
A
T
T
H
A
L
T
N
P
Q
V
N
R
A
R
P
P
S
G
Q
P
D
P
Y
I
P
V
G
V
V
K
Q
T
E
K
G
I
V
V
R
G
A
R
M
T
A
T
F
P
-
L
--
A
D
--
E
V
L
I
F
--
P
S
I
L
-
L
Q
-
A
-
G
S
EKY
A
L
A
--
F
A
L
P
T
S
T
P
G
L
H
F
V
-------
C
R
E
A
L
----
V
G
G
----
D
S
----
P
F
D
H
P
L
S
-
S
R
V
E
--
E
M
D
C
L
V
I
F
D
D
V
L
V
P
W
E
R
V
F
I
L
G
N
V
E
L
C
N
N
A
Y
G
A
-
T
G
-
A
L
N
H
M
A
H
Q
V
V
A
L
K
T
A
K
T
E
A
F
L
G
V
A
A
L
M
A
E
G
---
I
--
G
A
D
V
Y
G
H
V
Q
E
K
I
A
E
I
I
V
Y
L
E
A
M
R
A
F
W
T
R
A
E
E
E
A
K
E
N
A
Y
G
L
L
V
P
--
D
R
G
A
L
-------
D
G
A
R
N
L
Y
P
R
L
Y
-
P
R
I
R
E
I
L
-
E
Q
I
G
-
A
S
G
L
--
I
T
--
L
--
P
S
E
K
D
F
-
K
G
---------
P
---------
L
G
P
F
L
E
K
F
L
Q
G
A
-
A
-
L
-
E
----
A
K
E
R
V
A
L
F
R
L
A
W
D
M
T
L
--
S
G
F
G
A
R
Q
E
L
Y
E
R
F
F
F
G
D
P
V
R
M
Y
Q
T
L
Y
N
V
Y
----
N
K
E
P
---
Y
K
E
R
---
I
H
A
F
L
------
3
PsiBlast_PDB
86.02
41%
-43
- C6 -
2YYJ
9
HPAB_THET8
A:
[4-469]
----
T
G
A
E
Y
I
E
A
L
K
T
R
-
P
P
N
L
W
Y
K
G
E
K
V
E
-
D
P
T
T
H
P
V
F
R
G
I
V
R
T
M
A
A
L
Y
D
L
Q
H
D
P
R
Y
R
E
V
L
T
Y
E
E
E
G
--
K
R
H
G
M
S
---
F
L
I
----
P
K
T
K
E
D
L
K
R
R
G
Q
A
Y
K
L
W
A
D
Q
-
N
L
G
M
-
M
G
R
--
S
P
D
Y
L
N
A
V
V
M
A
Y
A
A
S
-----
A
D
Y
F
G
-----
E
--------------
F
A
E
N
V
R
N
Y
Y
R
Y
L
R
D
Q
D
L
A
T
T
H
A
L
T
N
P
Q
V
N
R
A
R
P
P
S
G
Q
P
D
P
Y
I
P
V
G
V
V
K
Q
T
E
K
G
I
V
V
R
G
A
R
M
T
A
T
F
P
-
L
--
A
D
--
E
V
L
I
F
P
S
T
L
L
Q
-
A
G
-
S
-
E
K
Y--
A
L
A
--
F
A
L
P
T
S
T
P
G
L
H
F
V
-------
C
R
E
A
L
----
V
G
G
----
D
S
----
P
F
D
H
P
L
S
-
S
R
V
E
--
E
M
D
C
L
V
I
F
D
D
V
L
V
P
W
E
R
V
F
I
L
G
N
V
E
L
C
N
N
A
Y
A
A
-
T
G
-
A
L
N
H
M
A
H
Q
V
V
A
L
K
T
A
K
T
E
A
F
L
G
V
A
A
L
M
A
E
G
---
I
--
G
A
D
V
Y
G
H
V
Q
E
K
I
A
E
I
I
V
Y
L
E
A
M
R
A
F
W
T
R
A
E
E
E
A
K
E
N
A
Y
G
L
L
V
P
--
D
R
G
A
L
-------
D
G
A
R
N
L
Y
P
R
L
Y
-
P
R
I
R
E
I
L
-
E
Q
I
G
-
A
S
G
L
--
I
T
--
L
--
P
S
E
K
D
F
-
K
G
---------
P
---------
L
G
P
F
L
E
K
F
L
Q
G
A
-
A
-
L
-
E
----
A
K
E
R
V
A
L
F
R
L
A
W
D
M
T
L
--
S
G
F
G
A
R
Q
E
L
Y
E
R
F
F
F
G
D
P
V
R
M
Y
Q
T
L
Y
N
V
Y
----
N
K
E
P
---
Y
K
E
R
---
I
R
A
F
L
------
4
PsiBlast_PDB
85.80
41%
-50
- C6 -
2YYK
5
HPAB_THET8
A:
[4-469]
----
T
G
A
E
Y
I
E
A
L
K
T
R
-
P
P
N
L
W
Y
K
G
E
K
V
E
-
D
P
T
T
H
P
V
F
R
G
I
V
R
T
M
A
A
L
Y
D
L
Q
H
D
P
R
Y
R
E
V
L
T
Y
E
E
E
G
--
K
R
H
G
M
S
---
F
L
I
----
P
K
T
K
E
D
L
K
R
R
G
Q
A
Y
K
L
W
A
D
Q
-
N
L
G
M
-
M
G
R
--
S
P
D
Y
L
N
A
V
V
M
A
Y
A
A
S
-----
A
D
Y
F
G
-----
E
--------------
F
A
E
N
V
R
N
Y
Y
R
Y
L
R
D
Q
D
L
A
T
T
H
A
L
T
N
P
Q
V
N
R
A
R
----
Q
P
D
P
Y
I
P
V
G
V
V
K
Q
T
E
K
G
I
V
V
R
G
A
R
M
T
A
T
F
P
-
L
--
A
D
--
E
V
L
I
F
--
P
S
I
L
-
L
Q
-
A
-
G
S
EKY
A
L
A
--
F
A
L
P
T
S
T
P
G
L
H
F
V
-------
C
R
E
A
L
----
V
G
G
----
D
S
----
P
F
D
H
P
L
S
-
S
R
V
E
--
E
M
D
C
L
V
I
F
D
D
V
L
V
P
W
E
R
V
F
I
L
G
N
V
E
L
C
N
N
A
Y
G
A
-
T
G
-
A
L
N
H
M
A
H
Q
V
V
A
L
K
T
A
K
T
E
A
F
L
G
V
A
A
L
M
A
E
G
---
I
--
G
A
D
V
Y
G
H
V
Q
E
K
I
A
E
I
I
V
Y
L
E
A
M
R
A
F
W
T
R
A
E
E
E
A
K
E
N
A
Y
G
L
L
V
P
--
D
R
G
A
L
-------
D
G
A
R
N
L
Y
P
R
L
Y
-
P
R
I
R
E
I
L
-
E
Q
I
G
-
A
S
G
L
--
I
T
--
L
--
P
S
E
K
D
F
-
K
G
---------
P
---------
L
G
P
F
L
E
K
F
L
Q
G
A
-
A
-
L
-
E
----
A
K
E
R
V
A
L
F
R
L
A
W
D
M
T
L
--
S
G
F
G
A
R
Q
E
L
Y
E
R
F
F
F
G
D
P
V
R
M
Y
Q
T
L
Y
N
V
Y
----
N
K
E
P
---
Y
K
E
R
---
I
H
A
F
L
------
2
PsiBlast_PDB
85.14
41%
-43
- C6 -
2YYI
5
HPAB_THET8
A:
[4-469]
----
T
G
A
E
Y
I
E
A
L
K
T
R
-
P
P
N
L
W
Y
K
G
E
K
V
E
-
D
P
T
T
H
P
V
F
R
G
I
V
R
T
M
A
A
L
Y
D
L
Q
H
D
P
R
Y
R
E
V
L
T
Y
E
E
E
G
--
K
R
H
G
M
S
---
F
L
I
----
P
K
T
K
E
D
L
K
R
R
G
Q
A
Y
K
L
W
A
D
Q
-
N
L
G
M
-
M
G
R
--
S
P
D
Y
L
N
A
V
V
M
A
Y
A
A
S
-----
A
D
Y
F
G
-----
E
--------------
F
A
E
N
V
R
N
Y
Y
R
Y
L
R
D
Q
D
L
A
T
T
H
A
L
T
N
P
Q
V
N
R
A
R
P
P
S
G
Q
P
D
P
Y
I
P
V
G
V
V
K
Q
T
E
K
G
I
V
V
R
G
A
R
M
T
A
T
F
P
-
L
--
A
D
--
E
V
L
I
F
P
--
L
L
Q
-
A
G
-
S
-
E
K
Y--
A
L
A
--
F
A
L
P
T
S
T
P
G
L
H
F
V
-------
C
R
E
A
L
----
V
G
G
----
D
S
----
P
F
D
H
P
L
S
-
S
R
V
E
--
E
M
D
C
L
V
I
F
D
D
V
L
V
P
W
E
R
V
F
I
L
G
N
V
E
L
C
N
N
A
Y
A
A
-
T
G
-
A
L
N
H
M
A
H
Q
V
V
A
L
K
T
A
K
T
E
A
F
L
G
V
A
A
L
M
A
E
G
---
I
--
G
A
D
V
Y
G
H
V
Q
E
K
I
A
E
I
I
V
Y
L
E
A
M
R
A
F
W
T
R
A
E
E
E
A
K
E
N
A
Y
G
L
L
V
P
--
D
R
G
A
L
-------
D
G
A
R
N
L
Y
P
R
L
Y
-
P
R
I
R
E
I
L
-
E
Q
I
G
-
A
S
G
L
--
I
T
--
L
--
P
S
E
K
D
F
-
K
G
---------
P
---------
L
G
P
F
L
E
K
F
L
Q
G
A
-
A
-
L
-
E
----
A
K
E
R
V
A
L
F
R
L
A
W
D
M
T
L
--
S
G
F
G
A
R
Q
E
L
Y
E
R
F
F
F
G
D
P
V
R
M
Y
Q
T
L
Y
N
V
Y
----
N
K
E
P
---
Y
K
E
R
---
I
R
A
F
L
------
1
PsiBlast_PDB
84.99
41%
-44
- C6 -
2YYG
5
HPAB_THET8
A:
[4-469]
----
T
G
A
E
Y
I
E
A
L
K
T
R
-
P
P
N
L
W
Y
K
G
E
K
V
E
-
D
P
T
T
H
P
V
F
R
G
I
V
R
T
M
A
A
L
Y
D
L
Q
H
D
P
R
Y
R
E
V
L
T
Y
E
E
E
G
--
K
R
H
G
M
S
---
F
L
I
----
P
K
T
K
E
D
L
K
R
R
G
Q
A
Y
K
L
W
A
D
Q
-
N
L
G
M
-
M
G
R
--
S
P
D
Y
L
N
A
V
V
M
A
Y
A
A
S
-----
A
D
Y
F
G
-----
E
--------------
F
A
E
N
V
R
N
Y
Y
R
Y
L
R
D
Q
D
L
A
T
T
H
A
L
T
N
P
Q
V
N
R
A
------
P
D
P
Y
I
P
V
G
V
V
K
Q
T
E
K
G
I
V
V
R
G
A
R
M
T
A
T
F
P
-
L
--
A
D
--
E
V
L
I
F
P
S
T
L
L
Q
-
A
G
-
S
-
E
K
Y--
A
L
A
--
F
A
L
P
T
S
T
P
G
L
H
F
V
-------
C
R
E
A
L
----
V
G
G
----
D
S
----
P
F
D
H
P
L
S
-
S
R
V
E
--
E
M
D
C
L
V
I
F
D
D
V
L
V
P
W
E
R
V
F
I
L
G
N
V
E
L
C
N
N
A
Y
A
A
-
T
G
-
A
L
N
H
M
A
H
Q
V
V
A
L
K
T
A
K
T
E
A
F
L
G
V
A
A
L
M
A
E
G
---
I
--
G
A
D
V
Y
G
H
V
Q
E
K
I
A
E
I
I
V
Y
L
E
A
M
R
A
F
W
T
R
A
E
E
E
A
K
E
N
A
Y
G
L
L
V
P
--
D
R
G
A
L
-------
D
G
A
R
N
L
Y
P
R
L
Y
-
P
R
I
R
E
I
L
-
E
Q
I
G
-
A
S
G
L
--
I
T
--
L
--
P
S
E
K
D
F
-
K
G
---------
P
---------
L
G
P
F
L
E
K
F
L
Q
G
A
-
A
-
L
-
E
----
A
K
E
R
V
A
L
F
R
L
A
W
D
M
T
L
--
S
G
F
G
A
R
Q
E
L
Y
E
R
F
F
F
G
D
P
V
R
M
Y
Q
T
L
Y
N
V
Y
----
N
K
E
P
---
Y
K
E
R
---
I
R
A
F
L
------
27
HHSearch
84.81
42%
-32
- C6 -
2YYK
5
HPAB_THET8
A:
[2-475]
--
A
R
T
G
A
E
Y
I
E
A
L
K
T
R
-
P
P
N
L
W
Y
K
G
E
K
V
E
-
D
P
T
T
H
P
V
F
R
G
I
V
R
T
M
A
A
L
Y
D
L
Q
H
D
P
R
Y
R
E
V
L
T
Y
E
E
--
E
G
K
R
H
G
M
S
---
F
L
I
----
P
K
T
K
E
D
L
K
R
R
G
Q
A
Y
K
L
W
A
D
Q
-
N
L
G
M
-
M
G
R
--
S
P
D
Y
L
N
A
V
V
M
A
Y
A
A
S
-----
A
D
Y
F
G
-------------------
E
F
A
E
N
V
R
N
Y
Y
R
Y
L
R
D
Q
D
L
A
T
T
H
A
L
T
N
P
Q
V
N
R
A
R
----
Q
P
D
P
Y
I
P
V
G
V
V
K
Q
T
E
K
G
I
V
V
R
G
A
R
M
T
A
T
F
-
P
L
--
A
D
--
E
V
L
I
F
P
S
I
L
-
L
-
Q
A
G
S
E
K
Y
---
A
L
A
--
F
A
L
P
T
S
T
P
G
L
H
F
V
-------
C
R
E
A
L
----
V
G
G
----
D
S
----
P
F
D
H
P
L
S
-
S
R
V
E
--
E
M
D
C
L
V
I
F
D
D
V
L
V
P
W
E
R
V
F
I
L
G
N
V
E
L
C
N
N
A
Y
G
A
-
T
G
-
A
L
N
H
M
A
H
Q
V
V
A
L
K
T
A
K
T
E
A
F
L
G
V
A
A
L
M
A
E
G
---
I
--
G
A
D
V
Y
G
H
V
Q
E
K
I
A
E
I
I
V
Y
L
E
A
M
R
A
F
W
T
R
A
E
E
E
A
K
E
N
A
Y
G
L
L
V
P
--
D
R
G
A
L
-------
D
G
A
R
N
L
Y
P
R
L
Y
-
P
R
I
R
E
I
L
-
E
Q
I
G
-
A
S
G
L
--
I
T
--
L
--
P
S
E
K
D
F
-
K
G
---------
P
---------
L
G
P
F
L
E
K
F
L
Q
G
A
-
A
-
L
-
E
----
A
K
E
R
V
A
L
F
R
L
A
W
D
M
T
L
--
S
G
F
G
A
R
Q
E
L
Y
E
R
F
F
F
G
D
P
V
R
M
Y
Q
T
L
Y
N
V
Y
----
N
K
E
P
---
Y
K
E
R
---
I
H
A
F
L
K
E
S
L
K
V
29
HHSearch
74.76
25%
-32
- C6 -
4OO2
1
?
A:
[18-501]
T
R
P
L
T
G
E
E
Y
L
E
S
L
R
-
D
-
A
R
E
V
Y
L
D
G
S
R
V
K
-
D
V
T
A
H
P
A
F
H
N
P
A
R
M
T
A
R
L
Y
D
S
L
H
D
P
A
Q
K
A
V
L
T
A
P
T
D
A
G
D
G
F
T
H
R
F
---
F
T
A
----
P
R
S
V
D
D
L
V
K
D
Q
A
A
I
A
S
W
A
R
K
-
S
Y
G
W
-
M
G
R
--
S
P
D
Y
K
A
S
F
L
G
T
L
G
A
N
-----
A
D
F
Y
-------------------
E
P
F
A
D
N
A
R
R
W
Y
R
E
S
Q
E
K
V
L
Y
W
N
H
A
F
L
H
P
P
V
D
R
S
----
E
V
G
--
D
V
F
I
H
V
E
R
E
T
D
A
G
L
V
V
S
G
A
K
V
V
A
T
G
S
A
L
--
T
H
--
A
A
F
I
S
H
W
G
L
-
P
-
I
K
-
D
R
K
F
---
A
L
V
--
A
T
V
P
M
D
A
D
G
L
K
V
I
-------
C
R
P
S
Y
----
S
A
N
A
A
T
T
G
S
----
P
F
D
N
P
L
S
-
S
R
L
D
--
E
N
D
A
I
L
V
L
D
Q
V
L
I
P
W
E
N
V
F
V
Y
G
N
L
G
K
V
H
L
L
A
G
Q
-
S
G
-
M
I
E
R
A
T
F
H
G
C
T
R
L
A
V
K
L
E
F
I
A
G
L
L
A
K
A
L
D
I
---
T
--
G
A
K
D
F
R
G
V
Q
T
R
L
G
E
V
L
A
W
R
N
L
F
W
S
L
S
D
A
A
A
R
N
P
V
P
W
K
N
G
T
L
L
P
--
N
P
Q
A
G
-------
M
A
Y
R
W
F
M
Q
I
G
Y
-
P
R
V
L
E
I
V
-
Q
Q
D
V
A
S
G
L
M
--
Y
V
--
N
--
S
S
T
E
D
F
-
R
N
---------
P
E--------
T
G
P
Y
L
E
K
Y
L
R
G
S
D
G
-
A
-
G
----
A
V
E
R
V
K
V
M
K
L
L
W
D
A
V
G
--
S
D
F
G
G
R
H
E
L
Y
E
R
N
Y
S
G
N
H
E
N
T
R
I
E
L
L
L
S
Q
T
A
S
G
K
L
D
S
---
Y
M
D
F
---
A
Q
A
C
M
D
E
Y
D
--
7
PsiBlast_PDB
71.15
27%
-18
- C6 -
4OO2
1
?
A:
[21-495]
---
L
T
G
E
E
Y
L
E
S
L
R
D
A
-
R
-
E
V
Y
L
D
G
S
R
V
K
-
D
V
T
A
H
P
A
F
H
N
P
A
R
M
T
A
R
L
Y
D
--
S
L
H
D
P
A
Q
K
A
V
L
T
A
P
T
D
A
G
D
-
G
F
T
HRF
F
T
A
----
P
R
S
V
D
D
L
V
K
D
Q
A
A
I
A
S
W
A
R
K
-
S
Y
G
W
-
M
G
R
--
S
P
D
Y
K
A
S
F
L
G
T
L
G
A
N
-----
A
D
F
Y
E
-------------------
P
F
A
D
N
A
R
R
W
Y
R
E
S
Q
E
K
V
L
Y
W
N
H
A
F
L
H
P
P
V
D
R
S
----
E
V
G
D
--
V
F
I
H
V
E
R
E
T
D
A
G
L
V
V
S
G
A
K
V
V
A
T
G
S
A
L
--
T
H
--
A
A
F
I
S
H
W
G
L
P
I
-
K
D
-
R
-
K
F
---
A
L
V
--
A
T
V
P
M
D
A
D
G
L
K
V
I
-------
C
R
P
S
Y
S
A
N
A
A
T
T
----
G
S
----
P
F
D
N
P
L
S
-
S
R
L
D
--
E
N
D
A
I
L
V
L
D
Q
V
L
I
P
W
E
N
V
F
V
Y
G
N
L
G
K
V
H
L
L
A
G
Q
-
S
G
M
I
E
R
A
T
F
H
G
C
T
-
R
L
A
V
K
L
E
F
I
A
G
L
L
A
K
A
L
D
I
---
T
--
G
A
K
D
F
R
G
V
Q
T
R
L
G
E
V
L
A
W
R
N
L
F
W
S
L
S
D
A
A
A
R
N
P
V
P
W
K
N
G
T
L
L
P
--
N
P
Q
A
G
-------
M
A
Y
R
W
F
M
Q
I
G
Y
-
P
R
V
L
E
I
V
-
Q
Q
D
V
-
A
S
G
L
MY
V
N
--
S
--
S
T
E
D
F
R
-
N
P
---------
E
---------
T
G
P
Y
L
E
K
Y
L
R
G
S
-
D
G
A
-
G
----
A
V
E
R
V
K
V
M
K
L
L
W
D
A
V
G
--
S
D
F
G
G
R
H
E
L
Y
E
R
N
Y
S
G
N
H
E
N
T
R
I
E
L
L
L
S
Q
----
T
A
S
G
---
K
L
D
S
---
Y
M
D
F
A
Q
A
----
15
Fugue
65.43
17%
-24
- C6 -
1U8V
3
HDVD_CLOAM
A:
[1-490]
-
M
L
M
T
A
E
Q
Y
I
E
S
L
R
K
L
-
N
T
R
V
Y
M
F
G
E
K
I
E
-
N
W
V
D
H
P
M
I
R
P
S
I
N
C
V
R
M
T
Y
E
L
A
Q
D
P
Q
Y
A
D
L
M
T
T
K
S
N
L
I
G
K
T
I
N
R
F
---
A
N
L
----
H
Q
S
T
D
D
L
R
K
K
V
K
M
Q
R
L
L
G
Q
K
-
T
A
S
C
-
F
Q
R
--
C
V
G
M
-
D
A
F
N
A
V
F
S
T
T
-----
Y
E
I
D
Q
-----
K
-----
Y
G
-----
T
N
Y
H
K
N
F
T
E
Y
L
K
Y
I
Q
E
N
D
L
I
V
D
G
A
M
T
D
P
K
G
D
R
G
L
A
P
S
A
Q
K
D
P
D
L
F
L
R
I
V
E
K
R
E
D
G
I
V
V
R
G
A
K
A
H
Q
T
G
S
I
N
--
S
H
--
E
H
I
I
M
P
T
I
A
M
T
-
E
A
-
D
-
K
D
Y--
A
V
S
--
F
A
C
P
S
D
A
D
G
L
F
M
I
-------
Y
G
R
Q
S
----
C
D
T
----
R
K
MEEG
A
D
I
D
L
G
N
-
K
Q
F
G
--
G
Q
E
A
L
V
V
F
D
N
V
F
I
P
N
D
R
I
F
L
C
Q
E
Y
D
F
A
G
M
M
V
E
R
-
F
A
-
G
Y
H
R
Q
S
Y
G
G
C
K
--
V
G
V
G
D
V
V
I
G
A
A
A
L
A
A
D
Y
---
N
--
G
A
Q
K
A
S
H
V
K
D
K
L
I
E
M
T
H
L
N
E
T
L
Y
C
C
G
I
A
C
S
A
E
G
Y
P
T
A
A
G
N
Y
Q
I
--
D
L
L
L
A
-------
N
V
C
K
Q
N
I
T
R
F
P
-
Y
E
I
V
R
L
A
-
E
D
I
A
-
G
G
L
M
--
V
T
--
M
--
P
S
E
A
D
F
-
K
S
ETVVGRDGE
T
---------
I
G
D
F
C
N
K
F
F
A
A
A
-
P
-
T
C
T
----
T
E
E
R
M
R
V
L
R
F
L
E
N
I
C
L
--
G
A
S
A
V
G
Y
R
T
E
S
M
H
G
A
G
S
P
Q
A
Q
R
I
M
I
A
R
Q
G
----
N
I
N
A
---
K
K
E
L
---
A
K
A
I
A
G
I
K
---
25
HHSearch
65.34
22%
-28
- C6 -
4G5E
-
?
A:
[2-483]
--
I
R
T
G
K
Q
Y
L
E
S
L
N
-
D
-
G
R
N
V
W
V
G
N
E
K
I
D
-
N
V
A
T
H
P
K
T
R
D
Y
A
Q
R
H
A
D
F
Y
D
L
H
H
R
P
D
L
Q
D
V
M
T
F
V
D
K
D
-
G
E
R
R
T
M
Q
---
W
F
G
----
H
Y
D
K
E
Q
L
R
R
K
R
K
Y
H
E
T
I
M
R
E
-
M
A
G
A
S
F
P
R
--
T
P
D
V
N
N
Y
V
L
Q
T
Y
I
D
D
-----
P
S
P
W
E
T
Q
TIG
A
-----
E
G
-----
K
V
K
A
K
N
I
V
D
F
V
N
F
A
K
K
H
D
L
N
C
A
P
Q
F
V
D
P
Q
M
-------------
P
G
L
R
V
I
E
K
N
D
K
G
I
V
V
S
G
V
K
A
I
G
T
G
V
A
F
--
A
D
--
W
I
H
I
G
V
F
F
R
-
P
-
G
I
-
P
G
D
Q
---
I
I
F
--
A
A
T
P
V
N
T
P
G
V
T
I
V
-------
C
R
E
S
V
----
V
K
E
-----
D
----
P
I
E
H
P
L
A
-
S
Q
G
D
--
E
L
D
G
M
T
V
F
D
N
V
F
I
P
W
S
H
V
F
H
L
G
N
P
E
H
A
K
L
Y
P
Q
---
R
-
V
F
D
W
L
H
Y
H
A
L
I
R
Q
S
V
R
A
E
L
M
A
G
L
A
I
L
I
T
E
H
---
I
--
G
T
N
K
I
P
A
V
Q
T
R
V
A
K
L
I
G
F
H
Q
A
M
L
A
H
I
V
A
S
E
E
L
G
F
H
T
P
G
G
A
Y
K
P
--
N
I
L
I
Y
-------
D
F
G
R
A
L
Y
L
E
N
F
-
S
Q
M
I
Y
E
L
-
V
D
L
S
-
G
R
S
A
--
L
I
--
F
--
A
S
E
D
Q
W
-
N
D
---------
E
A--------
L
N
G
W
F
E
R
M
N
N
G
P
-
V
-
G
-
Q
----
P
H
D
R
V
K
I
G
R
V
I
R
D
L
F
L
--
T
D
W
G
N
R
L
F
V
F
E
N
F
N
G
T
P
L
Q
A
I
R
M
L
T
M
Q
R
A
----
E
F
S
A
AGP
Y
G
T
L
---
A
R
K
V
C
G
I
E
L
T
-
28
HHSearch
65.03
22%
-15
- C6 -
3HWC
-
TFTD_BURCE
A:
[3001-3480]
--
M
R
T
G
K
Q
Y
L
E
S
L
N
-
D
-
G
R
V
V
W
V
G
N
E
K
I
D
-
N
V
A
T
H
P
L
T
R
D
Y
A
E
R
V
A
Q
F
Y
D
L
H
H
R
P
D
L
Q
D
V
L
T
F
V
D
A
-
D
G
V
R
R
S
R
Q
---
W
Q
D
----
P
K
D
A
A
G
L
R
V
K
R
K
Y
H
E
T
I
L
R
E
I
A
A
G
S
-
Y
G
R
--
L
P
D
A
H
N
Y
T
F
T
T
Y
A
D
D
-----
P
E
V
W
E
-----
K
Q
SIGA
E
G
-----
R
N
L
T
Q
N
I
H
N
F
L
K
L
L
R
E
K
D
L
N
C
P
L
N
F
V
D
P
Q
T
D
R
S
S
D
A
A
Q
A
R
--
S
P
N
L
R
I
V
E
K
T
D
D
G
I
I
V
N
G
V
K
A
V
G
T
G
I
A
F
--
G
D
--
Y
M
H
I
G
C
L
Y
R
-
P
-
G
I
-
P
G
E
Q
---
V
I
F
--
A
A
I
P
T
N
T
P
G
V
T
V
F
-------
C
R
E
S
T
----
V
K
N
-----
D
----
P
A
E
H
P
L
A
-
S
Q
G
D
--
E
L
D
S
T
T
V
F
D
N
V
F
I
P
W
E
Q
V
F
H
I
G
N
P
E
H
A
K
L
Y
P
---
Q
R
-
I
F
D
W
V
H
Y
H
I
L
I
R
Q
V
L
R
A
E
L
I
V
G
L
A
I
L
I
T
E
H
---
I
--
G
T
S
K
L
P
T
V
S
A
R
V
A
K
L
V
A
F
H
L
A
M
Q
A
H
L
I
A
S
E
E
T
G
F
H
T
K
G
G
R
Y
K
P
--
N
P
L
I
Y
-------
D
F
G
R
A
H
F
L
Q
N
Q
-
M
S
V
M
Y
E
L
-
L
D
L
A
-
G
R
S
S
--
L
M
--
I
--
P
S
E
G
Q
W
-
D
D
---------
S
Q--------
S
G
Q
W
F
V
K
L
N
N
G
P
-
K
-
G
-
N
----
P
R
E
R
V
Q
I
G
R
V
I
R
D
L
Y
L
--
T
D
W
G
G
R
Q
F
M
F
E
N
F
N
G
T
P
L
F
A
V
F
A
A
T
M
T
R
D
----
D
M
S
A
---
A
G
T
Y
GK
F
A
S
Q
V
C
G
I
E
---
9
PsiBlast_PDB
64.50
24%
3
- C6 -
3HWC
-
TFTD_BURCE
A:
[3004-3450]
-----
G
K
Q
Y
L
E
S
L
N
D
--
G
R
V
V
W
V
G
N
E
K
I
D
-
N
V
A
T
H
P
L
T
R
D
Y
A
E
R
V
A
Q
F
Y
D
L
H
H
R
P
D
L
Q
D
V
L
T
F
-
V
D
A
D
G
V
R
R
S
R
Q
---
W
Q
D
----
P
K
D
A
A
G
L
R
V
K
R
K
Y
H
E
T
I
L
R
E
I
A
A
G
S
-
Y
G
R
--
L
P
D
A
H
N
Y
T
F
T
T
Y
A
D
D
-----
P
E
V
W
E
-----
K
-----
Q
S
IGAEG
R
N
L
T
Q
N
I
H
N
F
L
K
L
L
R
E
K
D
L
N
C
P
L
N
F
V
D
P
Q
T
D
R
S
S
D
--
A
A
Q
A
R
S
P
N
L
R
I
V
E
K
T
D
D
G
I
I
V
N
G
V
K
A
V
G
T
G
I
A
F
--
G
D
--
Y
M
H
I
G
C
L
Y
R
P
G
-
I
P
-
G
-
E
Q
---
V
I
F
--
A
A
I
P
T
N
T
P
G
V
T
V
F
-------
C
R
E
S
T
----
V
K
N
----
D
P
----
A
-
E
H
P
L
A
-
S
Q
G
D
--
E
L
D
S
T
T
V
F
D
N
V
F
I
P
W
E
Q
V
F
H
I
G
N
P
E
H
A
K
--
L
Y
P
-
Q
R
-
I
F
D
W
V
H
Y
H
I
L
I
R
Q
V
L
R
A
E
L
I
V
G
L
A
I
L
I
T
E
H
---
I
--
G
T
S
K
L
P
T
V
S
A
R
V
A
K
L
V
A
F
H
L
A
M
Q
A
H
L
I
A
S
E
E
T
G
F
H
T
K
G
G
R
Y
K
P
--
N
--
P
L
I
Y
D
F
G
R
A
H
F
L
Q
N
Q
M
S
V
M
Y
-----
E
L
L
-
D
L
A
G
-
R
S
S
L
--
M
---
I
--
P
S
E
G
Q
W
D
D
S
---------
Q
---------
S
G
Q
W
F
V
K
L
N
N
G
P
-
K
-
G
-
N
----
P
R
E
R
V
Q
I
G
R
V
I
R
D
L
Y
L
--
T
D
W
G
G
R
Q
F
M
F
E
N
-
F
N
G
T
P
L
---------------------------------------
26
HHSearch
63.57
19%
7
- C6 -
1U8V
3
HDVD_CLOAM
A:
[1-490]
-
M
L
M
T
A
E
Q
Y
I
E
S
L
R
-
K
L
N
T
R
V
Y
M
F
G
E
K
I
E
-
N
W
V
D
H
P
M
I
R
P
S
I
N
C
V
R
M
T
Y
E
L
A
Q
D
P
Q
Y
A
D
L
M
T
T
K
S
N
L
I
G
K
T
I
N
R
F
---
A
N
L
----
H
Q
S
T
D
D
L
R
K
K
V
K
M
Q
R
L
L
G
Q
K
-
T
A
S
C
-
F
Q
R
C
V
G
M
D
A
F
N
A
V
F
S
T
T
Y
E
I
-----
D
Q
--------
K
-----
Y
G
-----
T
N
Y
H
K
N
F
T
E
Y
L
K
Y
I
Q
E
N
D
L
I
V
D
G
A
M
T
D
P
K
G
D
R
G
L
A
P
S
A
Q
K
D
P
D
L
F
L
R
I
V
E
K
R
E
D
G
I
V
V
R
G
A
K
A
H
Q
T
G
S
I
N
--
S
H
--
E
H
I
I
M
P
T
I
A
-
M
-
T
E
A
D
K
D
Y
---
A
V
S
--
F
A
C
P
S
D
A
D
G
L
F
M
I
-------
Y
G
R
Q
S
----
C
D
T
RKM-
E
E
----
G
A
D
I
D
L
G
N
K
Q
F
G
--
G
Q
E
A
L
V
V
F
D
N
V
F
I
P
N
D
R
I
F
L
C
Q
E
Y
D
F
A
G
M
M
V
---
E
R
-
F
A
G
Y
H
R
Q
S
Y
G
G
C
K
V
G
V
G
D
V
V
I
G
A
A
A
L
A
A
D
Y
---
N
--
G
A
Q
K
A
S
H
V
K
D
K
L
I
E
M
T
H
L
N
E
T
L
Y
C
C
G
I
A
C
S
A
E
G
Y
P
T
A
A
G
N
Y
Q
I
--
D
L
L
L
A
-------
N
V
C
K
Q
N
I
T
R
F
P
-
Y
E
I
V
R
L
A
-
E
D
I
A
-
G
G
L
M
--
V
T
--
M
--
P
S
E
A
D
F
-
K
S
---------
E
TVVGRDGET
I
G
D
F
C
N
K
F
F
A
A
A
P
T
-
C
-
T
----
T
E
E
R
M
R
V
L
R
F
L
E
N
I
C
L
G
A
S
A
V
G
Y
R
T
--
E
S
M
H
G
A
G
S
P
Q
A
Q
R
I
M
I
A
R
Q
G
----
N
I
N
A
---
K
K
E
L
---
A
K
A
I
A
G
I
K
---
10
PsiBlast_PDB
62.80
20%
-6
- C6 -
1U8V
3
HDVD_CLOAM
A:
[2-453]
--
L
M
T
A
E
Q
Y
I
E
S
L
R
K
L
-
N
T
R
V
Y
M
F
G
E
K
I
E
-
N
W
V
D
H
P
M
I
R
P
S
I
N
C
V
R
M
T
Y
E
L
A
Q
D
P
Q
Y
A
D
L
M
T
T
----
K
S
N
L
I
G
K
T
---
I
N
R
FANL
H
Q
S
T
D
D
L
R
K
K
V
K
M
Q
R
L
L
G
Q
K
-
T
A
S
C
-
F
Q
R
--
C
V
G
-
M
D
A
F
N
A
V
F
S
T
T
-----
Y
E
I
D
Q
-----
K
-----
Y
G
-----
T
N
Y
H
K
N
F
T
E
Y
L
K
Y
I
Q
E
N
D
L
I
V
D
G
A
M
T
D
P
K
G
D
R
G
L
A
P
S
A
Q
K
D
P
D
L
F
L
R
I
V
E
K
R
E
D
G
I
V
V
R
G
A
K
A
H
Q
T
-
G
S
I
--
N
S
--
H
E
H
I
I
M
P
T
I
A
M
-
T
E
-
A
-
D
K
---
D
Y
A
V
S
F
A
C
P
S
D
A
D
G
L
F
M
I
Y
G
R
Q
SCD
T
R
K
M
E
----
E
G
A
----
D
I
----
D
L
G
N
----
K
Q
F
G
--
G
Q
E
A
L
V
V
F
D
N
V
F
I
P
N
D
R
I
F
L
C
Q
E
Y
D
F
A
G
M
M
V
E
R
F
A
G
-
Y
H
R
Q
S
Y
G
G
C
K
V
G
V
G
---
D
V
V
I
G
A
A
A
L
A
A
D
Y
---
N
--
G
A
Q
K
A
S
H
V
K
D
K
L
I
E
M
T
H
L
N
E
T
L
Y
C
C
G
I
A
C
S
A
E
G
Y
P
T
A
A
G
N
Y
Q
I
--
D
L
L
L
A
-------
N
V
C
K
Q
N
I
T
R
F
P
-
Y
E
I
V
R
L
A
-
E
D
I
A
-
G
G
L
M
--
V
T
--
M
--
P
S
E
A
D
F
-
K
S
---------
E
TVVGRDGET
I
G
D
F
C
N
K
F
F
A
A
A
-
P
-
T
C
T
----
T
E
E
R
M
R
V
L
R
F
L
E
N
I
C
L
G
A
S
A
V
G
Y
R
----------------------------------------------------
8
PsiBlast_PDB
61.66
27%
-16
- C6 -
4G5E
-
?
A:
[2-452]
--
I
R
T
G
K
Q
Y
L
E
S
L
N
D
G
-
R
N
-
V
W
V
G
N
E
K
I
D
-
N
V
A
T
H
P
K
T
R
D
Y
A
Q
R
H
A
D
F
Y
D
L
H
H
R
P
D
L
Q
D
V
M
T
F
-
V
D
K
D
G
E
R
R
T
M
Q
---
W
F
G
----
H
Y
D
K
E
Q
L
R
R
K
R
K
Y
H
E
T
I
M
R
E
-
M
A
G
A
S
F
P
R
--
T
P
D
V
N
N
Y
V
L
Q
T
Y
I
D
D
P
S
P
W
E
T
Q
T
I
G
-----
A
-----
E
G
-----
K
V
K
A
K
N
I
V
D
F
V
N
F
A
K
K
H
D
L
N
C
A
P
Q
F
V
D
P
Q
M
-------------
P
G
L
R
V
I
E
K
N
D
K
G
I
V
V
S
G
V
K
A
I
G
T
G
V
A
F
--
A
D
W
I
H
I
G
V
F
F
R
P
G
I
---
P
-
G
-
D
Q
---
I
I
F
--
A
A
T
P
V
N
T
P
G
V
T
I
V
-------
C
R
E
S
V
----
V
K
E
----
D
P
-----
I
E
H
P
L
A
-
S
Q
G
D
--
E
L
D
G
M
T
V
F
D
N
V
F
I
P
W
S
H
V
F
H
L
G
N
P
E
H
A
K
-
L
Y
P
Q
-
R
V
-
F
D
W
L
H
Y
H
-
A
L
I
R
Q
S
V
R
A
E
L
M
A
G
L
A
I
L
I
T
E
H
---
I
--
G
T
N
K
I
P
A
V
Q
T
R
V
A
K
L
I
G
F
H
Q
A
M
L
A
H
I
V
A
S
E
------
E
L
G
F
H
T
P
GG
A
Y
K
P
N
-------
I
L
I
Y
D
F
G
R
A
L
Y
L
E
N
F
S
Q
M
I
Y
E
L
V
D
-
L
S
G
R
--
S
A
--
L
I
F
A
S
E
D
Q
W
-
N
D
---------
E
---------
A
---
L
N
G
W
F
E
R
M
-
N
-
N
-
G
PVGQ
P
H
D
R
V
K
I
G
R
V
I
R
D
L
F
L
--
T
D
W
G
N
R
L
F
V
F
E
N
-
F
N
G
T
P
L
Q
--------------------------------------
39
HHSearch
43.49
16%
-78
- C6 -
3SWO
4
?
A:
[124-370]
------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
E
Q
K
N
E
W
L
P
R
L
A
A
G
D
A
I
G
C
F
G
L
T
E
P
D
F
G
S
N
P
A
-------
G
M
R
T
R
A
R
R
-
D
G
S
D
W
I
L
N
G
T
K
M
W
I
T
N
G
N
L
--
A
D
--
V
A
T
V
W
A
Q
T
D
--------
D
G
---
I
R
G
--
F
L
V
P
T
D
T
P
G
F
T
A
N
-------
E
I
H
R
----------------------
K
L
S
-
L
R
A
---
S
V
T
S
E
L
V
L
D
N
V
R
L
P
A
S
A
Q
L
P
L
---
A
E
G
L
S
A
P
L
---
S
-
C
L
N
E
A
R
F
G
I
V
F
G
A
L
G
A
A
R
D
S
L
E
T
T
I
A
Y
T
Q
S
REV
F
DK
P
L
S
N
Y
Q
L
T
Q
E
K
L
A
N
M
T
V
E
L
G
K
G
M
L
L
A
I
H
L
G
R
I
K
D
A
E
--
G
---
V
--
R
P
E
Q
I
-------
S
L
G
K
L
N
N
V
R
E
A
-
I
A
I
A
R
E
C
-
R
T
L
L
-
G
G
S
G
--
I
T
LE
Y
--
S
P
L
R
H
A
-
N
N
---------
L
-----------------------------------------------------------------------------------------------------------
34
HHSearch
40.76
12%
-80
- C6 -
2IX5
5
ACOX4_ARATH
A:
[153-401]
------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
A
Q
K
E
K
Y
L
P
S
L
A
Q
L
N
T
V
A
C
W
A
L
T
E
P
D
N
G
S
D
A
S
-------
G
L
G
T
T
A
T
K
-
V
E
G
G
W
K
I
N
G
Q
K
R
W
I
G
N
S
T
F
--
A
D
--
L
L
I
I
F
A
R
N
T
-
T
----
T
-
N
Q
---
I
N
G
--
F
I
V
K
K
D
A
P
G
L
K
A
T
-------
K
I
P
N
K
----------------------
I
G
-
L
R
M
---
V
Q
N
G
D
I
L
L
Q
N
V
F
V
P
D
E
D
R
L
P
G
--
V
N
-
S
F
Q
D
T
---
S
K
-
V
L
A
V
S
R
V
M
V
A
W
Q
P
I
G
I
S
M
G
I
Y
D
M
C
H
R
Y
L
K
E
RKQ
F
GA
P
L
A
A
F
Q
L
N
Q
Q
K
L
V
Q
M
L
G
N
V
Q
A
M
F
L
M
G
W
R
L
C
K
L
Y
E
T
G
---
Q
--
M
--
T
P
G
Q
A
-------
S
L
G
K
A
W
I
S
S
K
A
-
R
E
T
A
S
L
G
-
R
E
L
L
-
G
G
N
G
--
I
L
AD
F
--
L
V
A
K
A
F
-
C
D
---------
L
-----------------------------------------------------------------------------------------------------------
30
HHSearch
40.23
14%
-44
- C6 -
2WBI
7
ACD11_HUMAN
A:
[133-395]
------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
E
Q
K
K
Q
W
L
E
P
L
L
Q
G
N
I
T
S
C
F
C
M
T
E
P
D
V
A
S
----
S
D
A
--
T
N
I
E
C
S
I
Q
R
-
D
E
D
S
Y
V
I
N
G
K
K
W
W
S
S
G
A
G
N
PK
C
K
--
I
A
I
V
L
G
R
T
Q
N
T
S
L
S
-
R
H
K
Q
---
H
S
M
--
I
L
V
P
M
N
T
P
G
V
K
I
I
-------
R
P
L
S
V
----------------------
F
G
-
Y
T
D
N
FH
G
G
H
F
E
I
H
F
N
Q
V
R
V
P
A
T
N
L
I
L
--
G
E
G
R
G
F
E
I
S
Q
---
G
-
R
L
G
P
G
R
I
H
H
C
M
R
T
V
G
L
A
E
R
A
L
Q
I
M
C
E
R
A
T
Q
R
IA
F
KK
K
L
Y
A
H
E
V
V
A
H
W
I
A
E
S
R
I
A
I
E
K
I
R
L
L
T
L
K
A
A
H
S
M
D
T
L
--
G
S
-
A
G
--
A
K
K
E
I
-------
A
M
I
K
V
A
A
P
R
A
V
-
S
K
I
V
D
W
A
-
I
Q
V
C
-
G
G
A
G
--
V
S
QD
Y
--
P
L
A
N
M
Y
-
A
I
---------
T
-----------------------------------------------------------------------------------------------------------
44
HHSearch
40.09
13%
-52
- C6 -
4U83
-
?
A:
[109-361]
------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
D
Q
K
R
R
F
L
P
K
M
A
C
G
E
W
I
G
G
F
A
L
T
E
P
---------------
L
K
T
R
A
R
L
-
D
G
D
H
Y
V
I
D
G
S
K
Q
F
I
T
S
G
K
N
--
G
N
--
V
V
I
V
F
A
V
T
D
-
P
-
A
A
-
G
K
K
G
---
I
S
A
--
F
I
V
P
T
D
T
P
G
Y
E
V
M
-------
S
V
E
H
K
----------------------
L
G
-
Q
H
S
---
S
D
T
C
A
L
G
F
T
N
M
R
V
P
V
E
N
R
L
G
A
--
E
G
E
G
Y
K
I
A
L
---
A
-
N
L
E
G
G
R
I
G
I
A
A
Q
A
V
G
M
A
R
A
A
F
E
A
A
R
D
Y
A
R
E
RIT
F
GK
P
I
I
E
H
Q
A
V
A
F
R
L
A
D
M
A
T
R
I
E
T
A
R
Q
M
V
L
H
A
A
A
L
R
E
A
G
---
K
--
P
--
C
L
T
E
A
-------
S
M
A
K
L
V
A
S
E
M
A
-
E
Q
V
C
S
A
A
-
I
Q
I
H
-
G
G
Y
G
--
Y
L
AD
Y
--
P
V
E
R
I
Y
-
R
D
---------
V
-----------------------------------------------------------------------------------------------------------