@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : bsu22110: (2016-07-04 )
MKLDAVTFGESMAMFYANEYGGLHEVSTFSKGLAGAESNVACGLARLGFRMGWMSKVGNDQLGTFILQELKKEGVDVSRVIRSQDENPTGLLLKSKVKEGDPQVTYYRKNSAASTLTTAEYPRDYFQCAGHLHVTGIPPALSAEMKDFTYHVMNDMRNAGKTISFDPNVRPSLWPDQATMVHTINDLAGLADWFFPGIAEGELLTGEKTPEGIADYYLKKGASFVAIKLGKEGAYFKTGTSEGFLEGCRVDRVVDTVGAGDGFAVGVISGILDGLSYKDAVQRGNAIGALQVQAPGDMDGLPTREKLASFLSAQRTVHQKKGDY
Atome Classification :
(20 SA)
.........10........20..-.-.....30........40........--50........60........70........80........90...-.....100-----.....-..110-.......--120.......130.......140........150.......160.......170.......180.......190..--......200.......--210.......220.......230.......240.......250-----........260.......270...--------------....280.......290.......300.......310.......320..
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MKL
D
A
V
TFG
E
S
M
A
M
F
Y
A
N
EYGGL-
H
-
E
V
S
T
F
S
KGLAGAE
S
N
V
A
C
G
L
A
R
L
G
F
--
R
M
G
W
M
S
KVGN
D
Q
L
G
T
F
I
L
Q
E
L
K
KEGV
D
V
S
R
V
I
R
SQDENPT
G
L
L
L
K
-
S
KVKEGDP-----
Q
V
T
Y
Y
-RKNSA-ASTL
T
T
A
--EY
P
R
D
Y
F
Q
CAG
H
L
H
VTGIPPA
L
-
S
A
E
M
K
D
F
T
Y
H
V
M
N
D
M
R
NAG
K
T
I
SFDPNVRPSLWPDQ
A
T
M
V
H
T
I
N
D
L
A
G
L
-
A
D
W
--FFPGIAEGELLTGEKT--P
E
G
I
A
D
Y
Y
L
KKGA
S
F
V
A
I
K
LGKEG
A
Y
F
KTGTSEG
F
L
E
GCRV
D
------
R
V
V
D
TVGAGDG
F
A
V
G
V
I
S
G
I
LDGL--------------
S
Y
K
D
A
V
QRGNAI
G
A
L
Q
V
QAPGDMDGLP
T
R
E
K
L
A
S
F
L
S
A
Q
R
T
V
H
QKKGDY
1
PsiBlast_PDB
89.33
48%
-77
- C1 -
4DU5
1
?
A:
[27-331]
--
L
D
V
I
T
F
G
E
A
M
M
L
L
V
A
D
R
P
G
P
L
-
E
-
H
A
E
A
F
H
K
R
T
A
G
A
E
T
N
V
A
I
G
L
A
R
L
G
L
--
K
V
G
W
A
S
R
L
G
T
D
S
M
G
R
Y
L
L
A
A
M
A
A
E
G
I
D
C
S
H
V
V
C
D
A
T
Q
K
-
T
G
F
Q
F
K
-
G
K
V
T
D
G
-
P
-----
P
V
E
Y
H
-
R
K
G
S
A
-
A
S
H
M
G
V
A
--
D
I
D
E
A
W
L
L
S
A
R
H
L
H
A
T
G
V
F
P
A
I
-
S
A
T
T
L
P
A
A
R
K
T
M
D
L
M
R
A
A
G
R
S
V
S
F
D
P
N
L
R
P
T
L
W
A
T
P
E
L
M
R
D
A
I
N
D
L
A
T
R
-
A
D
W
--
V
L
P
G
M
E
E
G
R
F
L
T
G
E
T
T
--
P
E
G
V
A
R
F
Y
R
Q
L
G
A
K
L
V
V
V
K
L
G
A
E
G
A
Y
F
D
G
E
A
G
S
G
R
V
A
G
F
P
-------------
V
G
A
G
D
G
F
A
V
G
V
I
S
A
L
L
D
G
L
--------------
G
V
P
E
A
V
K
R
G
A
W
I
G
A
R
A
V
Q
------
G
L
P
T
R
A
E
L
-----------------
60
HHSearch
82.53
48%
-32
- C1 -
4DU5
1
?
A:
[26-334]
-
A
L
D
V
I
T
F
G
E
A
M
M
L
L
V
A
D
R
P
G
P
L
-
E
-
H
A
E
A
F
H
K
R
T
A
G
A
E
T
N
V
A
I
G
L
A
R
L
G
L
--
K
V
G
W
A
S
R
L
G
T
D
S
M
G
R
Y
L
L
A
A
M
A
A
E
G
I
D
C
-
S
H
V
V
C
D
A
T
Q
K
T
G
F
Q
F
K
G
K
V
T
D
G
--
P
-----
P
V
E
Y
H
-
R
K
G
S
A
-
A
S
H
M
G
V
A
--
D
I
D
E
A
W
L
L
S
A
R
H
L
H
A
T
G
V
F
P
A
I
-
S
A
T
T
L
P
A
A
R
K
T
M
D
L
M
R
A
A
G
R
S
V
S
F
D
P
N
L
R
P
T
L
W
A
T
P
E
L
M
R
D
A
I
N
D
L
A
T
R
-
A
D
W
--
V
L
P
G
M
E
E
G
R
F
L
T
G
E
T
T
--
P
E
G
V
A
R
F
Y
R
Q
L
G
A
K
L
V
V
V
K
L
G
A
E
G
A
Y
F
D
G
E
A
G
S
G
R
V
A
G
F
P
-------------
V
G
A
G
D
G
F
A
V
G
V
I
S
A
L
L
D
G
L
--------------
G
V
P
E
A
V
K
R
G
A
W
I
G
A
R
A
V
Q
------
G
L
P
T
R
A
E
L
N
A
A
--------------
5
PsiBlast_PDB
76.57
34%
-61
- C1 -
1V1S
-
KDGK_THET8
A:
[2-302]
--
L
E
V
V
T
A
G
E
P
L
V
A
L
V
P
Q
E
P
G
H
L
-
R
-
G
K
R
L
L
E
V
Y
V
G
G
A
E
V
N
V
A
V
A
L
A
R
L
G
V
--
K
V
G
F
V
G
R
V
G
E
D
E
L
G
A
M
V
E
E
R
L
R
A
E
G
V
D
L
T
H
F
R
R
A
P
--
G
F
T
G
L
Y
L
R
-
E
Y
L
P
L
G
Q
G
-----
R
V
F
Y
Y
-
R
K
G
S
A
-
G
S
A
L
A
P
G
--
A
F
D
P
D
Y
L
E
G
V
R
F
L
H
L
S
G
I
T
P
A
L
-
S
P
E
A
R
A
F
S
L
W
A
M
E
E
A
K
R
R
G
V
R
V
S
L
D
V
N
Y
R
Q
T
L
W
S
P
E
E
A
R
G
F
L
E
R
A
L
P
G
V
--
D
L
--
L
F
L
S
E
E
E
A
E
L
L
F
G
R
-------
V
E
E
A
L
R
A
L
S
A
P
E
V
V
L
K
R
G
A
K
G
A
W
-------
A
F
V
D
G
R
R
V
E
G
SAFAV
E
A
V
D
P
V
G
A
G
D
A
F
A
A
G
Y
L
A
G
A
V
W
G
L
--------------
P
V
E
E
R
L
R
L
A
N
L
L
G
A
S
V
A
A
S
R
G
D
H
E
G
A
P
Y
R
E
D
L
E
V
L
L
K
------------
4
PsiBlast_PDB
76.27
34%
-65
- C1 -
1V1B
1
KDGK_THET8
A:
[2-301]
--
L
E
V
V
T
A
G
E
P
L
V
A
L
V
P
Q
E
P
G
H
L
-
R
-
G
K
R
L
L
E
V
Y
V
G
G
A
E
V
N
V
A
V
A
L
A
R
L
G
V
--
K
V
G
F
V
G
R
V
G
E
D
E
L
G
A
M
V
E
E
R
L
R
A
E
G
V
D
L
T
H
F
R
R
A
P
--
G
F
T
G
L
Y
L
R
-
E
Y
L
P
L
G
Q
G
-----
R
V
F
Y
Y
-
R
K
G
S
A
-
G
S
A
L
A
P
G
--
A
F
D
P
D
Y
L
E
G
V
R
F
L
H
L
S
G
I
T
P
A
L
-
S
P
E
A
R
A
F
S
L
W
A
M
E
E
A
K
R
R
G
V
R
V
S
L
D
V
N
Y
R
Q
T
L
W
S
P
E
E
A
R
G
F
L
E
R
A
L
P
G
V
--
D
L
--
L
F
L
S
E
E
E
A
E
L
L
F
G
R
-------
V
E
E
A
L
R
A
L
S
A
P
E
V
V
L
K
R
G
A
K
G
A
W
-------
A
F
V
D
G
R
R
V
E
G
S
A
F
AV
E
A
V
D
P
V
G
A
G
D
A
F
A
A
G
Y
L
A
G
A
V
W
G
L
--------------
P
V
E
E
R
L
R
L
A
N
L
L
G
A
S
V
A
A
S
R
G
D
H
E
G
A
P
Y
R
E
D
L
E
V
L
L
-------------
23
PsiBlast_CBE
76.19
34%
-62
- C1 -
1V1B
1
KDGK_THET8
B:
[2-301]
--
L
E
V
V
T
A
G
E
P
L
V
A
L
V
P
Q
E
P
G
H
L
-
R
-
G
K
R
L
L
E
V
Y
V
G
G
A
E
V
N
V
A
V
A
L
A
R
L
G
V
--
K
V
G
F
V
G
R
V
G
E
D
E
L
G
A
M
V
E
E
R
L
R
A
E
G
V
D
L
T
H
F
R
R
A
P
--
G
F
T
G
L
Y
L
R
-
E
Y
L
P
L
G
Q
G
-----
R
V
F
Y
Y
-
R
K
G
S
A
-
G
S
A
L
A
P
G
--
A
F
D
P
D
Y
L
E
G
V
R
F
L
H
L
S
G
I
T
P
A
L
-
S
P
E
A
R
A
F
S
L
W
A
M
E
E
A
K
R
R
G
V
R
V
S
L
D
V
N
Y
R
Q
T
L
W
S
P
E
E
A
R
G
F
L
E
R
A
L
P
G
V
--
D
L
--
L
F
L
S
E
E
E
A
E
L
L
F
G
R
-------
V
E
E
A
L
R
A
L
S
A
P
E
V
V
L
K
R
G
A
K
G
A
W
-------
A
F
V
D
G
R
R
V
E
GSAFAV
E
A
V
D
P
V
G
A
G
D
A
F
A
A
G
Y
L
A
G
A
V
W
G
L
--------------
P
V
E
E
R
L
R
L
A
N
L
L
G
A
S
V
A
A
S
R
G
D
H
E
G
A
P
Y
R
E
D
L
E
V
L
L
-------------
25
PsiBlast_CBE
75.96
34%
-62
- C1 -
1V19
1
KDGK_THET8
B:
[2-302]
--
L
E
V
V
T
A
G
E
P
L
V
A
L
V
P
Q
E
P
G
H
L
-
R
-
G
K
R
L
L
E
V
Y
V
G
G
A
E
V
N
V
A
V
A
L
A
R
L
G
V
--
K
V
G
F
V
G
R
V
G
E
D
E
L
G
A
M
V
E
E
R
L
R
A
E
G
V
D
L
T
H
F
R
R
A
P
--
G
F
T
G
L
Y
L
R
-
E
Y
L
P
L
G
Q
G
-----
R
V
F
Y
Y
-
R
K
G
S
A
-
G
S
A
L
A
P
G
--
A
F
D
P
D
Y
L
E
G
V
R
F
L
H
L
S
G
I
T
P
A
L
-
S
P
E
A
R
A
F
S
L
W
A
M
E
E
A
K
R
R
G
V
R
V
S
L
D
V
N
Y
R
Q
T
L
W
S
P
E
E
A
R
G
F
L
E
R
A
L
P
G
V
--
D
L
--
L
F
L
S
E
E
E
A
E
L
L
F
G
R
-------
V
E
E
A
L
R
A
L
S
A
P
E
V
V
L
K
R
G
A
K
G
A
W
-------
A
F
V
D
G
R
R
V
E
GSAFAV
E
A
V
D
P
V
G
A
G
D
A
F
A
A
G
Y
L
A
G
A
V
W
G
L
--------------
P
V
E
E
R
L
R
L
A
N
L
L
G
A
S
V
A
A
S
R
G
D
H
E
G
A
P
Y
R
E
D
L
E
V
L
L
K
------------
22
PsiBlast_CBE
75.87
34%
-61
- C1 -
1V1B
1
KDGK_THET8
C:
[2-301]
--
L
E
V
V
T
A
G
E
P
L
V
A
L
V
P
Q
E
P
G
H
L
-
R
-
G
K
R
L
L
E
V
Y
V
G
G
A
E
V
N
V
A
V
A
L
A
R
L
G
V
--
K
V
G
F
V
G
R
V
G
E
D
E
L
G
A
M
V
E
E
R
L
R
A
E
G
V
D
L
T
H
F
R
R
A
P
--
G
F
T
G
L
Y
L
R
-
E
Y
L
P
L
G
Q
G
-----
R
V
F
Y
Y
-
R
K
G
S
A
-
G
S
A
L
A
P
G
--
A
F
D
P
D
Y
L
E
G
V
R
F
L
H
L
S
G
I
T
P
A
L
-
S
P
E
A
R
A
F
S
L
W
A
M
E
E
A
K
R
R
G
V
R
V
S
L
D
V
N
Y
R
Q
T
L
W
S
P
E
E
A
R
G
F
L
E
R
A
L
P
G
V
--
D
L
--
L
F
L
S
E
E
E
A
E
L
L
F
G
R
-------
V
E
E
A
L
R
A
L
S
A
P
E
V
V
L
K
R
G
A
K
G
A
W
-------
A
F
V
D
G
R
R
V
E
GSAFAV
E
A
V
D
P
V
G
A
G
D
A
F
A
A
G
Y
L
A
G
A
V
W
G
L
--------------
P
V
E
E
R
L
R
L
A
N
L
L
G
A
S
V
A
A
S
R
G
D
H
E
G
A
P
Y
R
E
D
L
E
V
L
L
-------------
21
PsiBlast_CBE
75.51
34%
-60
- C1 -
1V1B
1
KDGK_THET8
D:
[2-301]
--
L
E
V
V
T
A
G
E
P
L
V
A
L
V
P
Q
E
P
G
H
L
-
R
-
G
K
R
L
L
E
V
Y
V
G
G
A
E
V
N
V
A
V
A
L
A
R
L
G
V
--
K
V
G
F
V
G
R
V
G
E
D
E
L
G
A
M
V
E
E
R
L
R
A
E
G
V
D
L
T
H
F
R
R
A
P
--
G
F
T
G
L
Y
L
R
-
E
Y
L
P
L
G
Q
G
-----
R
V
F
Y
Y
-
R
K
G
S
A
-
G
S
A
L
A
P
G
--
A
F
D
P
D
Y
L
E
G
V
R
F
L
H
L
S
G
I
T
P
A
L
-
S
P
E
A
R
A
F
S
L
W
A
M
E
E
A
K
R
R
G
V
R
V
S
L
D
V
N
Y
R
Q
T
L
W
S
P
E
E
A
R
G
F
L
E
R
A
L
P
G
V
--
D
L
--
L
F
L
S
E
E
E
A
E
L
L
F
G
R
-------
V
E
E
A
L
R
A
L
S
A
P
E
V
V
L
K
R
G
A
K
G
A
W
-------
A
F
V
D
G
R
R
V
E
GSAFAV
E
A
V
D
P
V
G
A
G
D
A
F
A
A
G
Y
L
A
G
A
V
W
G
L
--------------
P
V
E
E
R
L
R
L
A
N
L
L
G
A
S
V
A
A
S
R
G
D
H
E
G
A
P
Y
R
E
D
L
E
V
L
L
-------------
2
PsiBlast_PDB
75.45
34%
-63
- C1 -
1V19
1
KDGK_THET8
A:
[2-302]
--
L
E
V
V
T
A
G
E
P
L
V
A
L
V
P
Q
E
P
G
H
L
-
R
-
G
K
R
L
L
E
V
Y
V
G
G
A
E
V
N
V
A
V
A
L
A
R
L
G
V
--
K
V
G
F
V
G
R
V
G
E
D
E
L
G
A
M
V
E
E
R
L
R
A
E
G
V
D
L
T
H
F
R
R
A
P
--
G
F
T
G
L
Y
L
R
-
E
Y
L
P
L
G
Q
G
-----
R
V
F
Y
Y
-
R
K
G
S
A
-
G
S
A
L
A
P
G
--
A
F
D
P
D
Y
L
E
G
V
R
F
L
H
L
S
G
I
T
P
A
L
-
S
P
E
A
R
A
F
S
L
W
A
M
E
E
A
K
R
R
G
V
R
V
S
L
D
V
N
Y
R
Q
T
L
W
S
P
E
E
A
R
G
F
L
E
R
A
L
P
G
V
--
D
L
--
L
F
L
S
E
E
E
A
E
L
L
F
G
R
-------
V
E
E
A
L
R
A
L
S
A
P
E
V
V
L
K
R
G
A
K
G
A
W
-------
A
F
V
D
G
R
R
V
E
G
S
A
F
AV
E
A
V
D
P
V
G
A
G
D
A
F
A
A
G
Y
L
A
G
A
V
W
G
L
--------------
P
V
E
E
R
L
R
L
A
N
L
L
G
A
S
V
A
A
S
R
G
D
H
E
G
A
P
Y
R
E
D
L
E
V
L
L
K
------------
24
PsiBlast_CBE
74.99
34%
-59
- C1 -
1V1A
2
KDGK_THET8
B:
[2-302]
--
L
E
V
V
T
A
G
E
P
L
V
A
L
V
P
Q
E
P
G
H
L
-
R
-
G
K
R
L
L
E
V
Y
V
G
G
A
E
V
N
V
A
V
A
L
A
R
L
G
V
--
K
V
G
F
V
G
R
V
G
E
D
E
L
G
A
M
V
E
E
R
L
R
A
E
G
V
D
L
T
H
F
R
R
A
P
--
G
F
T
G
L
Y
L
R
-
E
Y
L
P
L
G
Q
G
-----
R
V
F
Y
Y
-
R
K
G
S
A
-
G
S
A
L
A
P
G
--
A
F
D
P
D
Y
L
E
G
V
R
F
L
H
L
S
G
I
T
P
A
L
-
S
P
E
A
R
A
F
S
L
W
A
M
E
E
A
K
R
R
G
V
R
V
S
L
D
V
N
Y
R
Q
T
L
W
S
P
E
E
A
R
G
F
L
E
R
A
L
P
G
V
--
D
L
--
L
F
L
S
E
E
E
A
E
L
L
F
G
R
-------
V
E
E
A
L
R
A
L
S
A
P
E
V
V
L
K
R
G
A
K
G
A
W
-------
A
F
V
D
G
R
R
V
E
GSAFAV
E
A
V
D
P
V
G
A
G
D
A
F
A
A
G
Y
L
A
G
A
V
W
G
L
--------------
P
V
E
E
R
L
R
L
A
N
L
L
G
A
S
V
A
A
S
R
G
D
H
E
G
A
P
Y
R
E
D
L
E
V
L
L
K
------------
3
PsiBlast_PDB
74.46
34%
-57
- C1 -
1V1A
2
KDGK_THET8
A:
[2-302]
--
L
E
V
V
T
A
G
E
P
L
V
A
L
V
P
Q
E
P
G
H
L
-
R
-
G
K
R
L
L
E
V
Y
V
G
G
A
E
V
N
V
A
V
A
L
A
R
L
G
V
--
K
V
G
F
V
G
R
V
G
E
D
E
L
G
A
M
V
E
E
R
L
R
A
E
G
V
D
L
T
H
F
R
R
A
P
--
G
F
T
G
L
Y
L
R
-
E
Y
L
P
L
G
Q
G
-----
R
V
F
Y
Y
-
R
K
G
S
A
-
G
S
A
L
A
P
G
--
A
F
D
P
D
Y
L
E
G
V
R
F
L
H
L
S
G
I
T
P
A
L
-
S
P
E
A
R
A
F
S
L
W
A
M
E
E
A
K
R
R
G
V
R
V
S
L
D
V
N
Y
R
Q
T
L
W
S
P
E
E
A
R
G
F
L
E
R
A
L
P
G
V
--
D
L
--
L
F
L
S
E
E
E
A
E
L
L
F
G
R
-------
V
E
E
A
L
R
A
L
S
A
P
E
V
V
L
K
R
G
A
K
G
A
W
-------
A
F
V
D
G
R
R
V
E
G
S
A
F
A
V
E
A
V
D
P
V
G
A
G
D
A
F
A
A
G
Y
L
A
G
A
V
W
G
L
--------------
P
V
E
E
R
L
R
L
A
N
L
L
G
A
S
V
A
A
S
R
G
D
H
E
G
A
P
Y
R
E
D
L
E
V
L
L
K
------------
68
HHSearch
74.37
34%
-71
- C1 -
1V1A
2
KDGK_THET8
A:
[1-302]
-
M
L
E
V
V
T
A
G
E
P
L
V
A
L
V
P
Q
E
P
G
H
L
-
R
-
G
K
R
L
L
E
V
Y
V
G
G
A
E
V
N
V
A
V
A
L
A
R
L
G
V
--
K
V
G
F
V
G
R
V
G
E
D
E
L
G
A
M
V
E
E
R
L
R
A
E
G
V
D
L
-
T
H
F
R
R
A
P
-
G
F
T
G
L
Y
L
R
-
E
Y
L
P
L
G
Q
G
-----
R
V
F
Y
Y
-
R
K
G
S
A
-
G
S
A
L
A
P
G
--
A
F
D
P
D
Y
L
E
G
V
R
F
L
H
L
S
G
I
T
P
A
L
-
S
P
E
A
R
A
F
S
L
W
A
M
E
E
A
K
R
R
G
V
R
V
S
L
D
V
N
Y
R
Q
T
L
W
S
P
E
-
E
A
R
G
F
L
E
R
A
L
P
G
-
V
D
L
--
L
F
L
S
E
E
E
A
E
L
L
F
G
R
V
E
----
E
A
---
L
R
A
L
S
A
P
E
V
V
L
K
R
G
A
K
G
A
W
A
F
V
D
G
R
R
V
E
G
S
A
F
A
V
-------
E
A
V
D
P
V
G
A
G
D
A
F
A
A
G
Y
L
A
G
A
V
W
G
L
--------------
P
V
E
E
R
L
R
L
A
N
L
L
G
A
S
V
A
A
S
R
G
D
H
E
G
A
P
Y
R
E
D
L
E
V
L
L
K
------------
10
PsiBlast_PDB
69.95
27%
1
- C1 -
2VAR
4
KDGK_SULSO
A:
[2-312]
--
V
D
V
I
A
L
G
E
P
L
I
Q
F
N
S
F
N
P
G
P
L
-
R
-
F
V
N
Y
F
E
K
H
V
A
G
S
E
L
N
F
C
I
A
V
V
R
N
H
L
--
S
C
S
L
I
A
R
V
G
N
D
E
F
G
K
N
I
I
E
Y
S
R
A
Q
G
I
D
T
S
H
-
I
K
V
D
N
E
S
F
T
G
I
Y
F
----
I
Q
R
G
Y
P
IPM
K
S
E
L
V
Y
Y
-
R
K
G
S
A
-
G
S
R
L
S
P
E
--
D
I
N
E
N
Y
V
R
N
S
R
L
V
H
S
T
G
I
T
L
A
I
-
S
D
N
A
K
E
A
V
I
K
A
F
----
E
L
A
K
S
R
S
L
D
T
N
I
R
P
K
L
W
S
S
L
E
K
A
K
E
T
I
L
S
I
L
K
K
-
Y
D
I
E
V
L
I
T
D
P
D
D
T
K
I
L
L
D
V
T
D
--
P
D
E
A
Y
R
K
Y
K
E
L
G
V
K
V
L
L
Y
K
L
G
S
K
G
A
I
A
Y
K
D
N
V
K
A
F
K
D
A
Y
K
V
P
-------
V
E
D
P
T
G
A
G
D
A
M
A
G
T
F
V
S
L
Y
L
Q
G
K
--------------
D
I
E
Y
S
L
A
H
G
I
A
A
S
T
L
V
I
T
V
R
G
D
N
E
L
T
P
T
L
E
D
A
E
R
F
L
N
E
F
K
---------
59
HHSearch
67.74
23%
-84
- C1 -
3LJS
-
?
A:
[4-331]
-
K
K
T
I
L
C
F
G
E
A
L
I
D
M
L
A
Q
P
L
V
K
K
-
G
-
M
P
R
A
F
L
Q
C
A
G
G
A
P
A
N
V
A
V
A
V
A
R
L
G
G
--
A
V
Q
F
V
G
M
L
G
S
D
M
F
G
D
F
L
F
D
S
F
A
E
A
G
V
V
T
-
D
G
I
V
R
T
S
T
A
K
T
A
L
A
F
V
-
A
L
D
A
H
G
E
R
-----
S
F
S
F
Y
-
R
P
P
A
A
-
D
L
L
F
R
V
E
--
H
F
Q
D
A
S
F
S
D
A
L
I
F
H
A
C
S
N
S
M
T
--
D
A
D
I
A
E
V
T
F
E
G
M
R
R
A
Q
A
A
G
A
I
V
S
F
D
L
N
F
R
P
M
L
W
P
N
G
E
N
P
A
S
R
L
W
K
G
L
S
L
-
A
D
V
--
V
K
L
S
S
E
E
L
D
Y
L
A
N
T
L
A
AD
A
N
A
V
I
Q
Q
L
W
Q
G
R
A
Q
L
L
L
V
T
D
A
A
G
P
V
H
W
Y
T
R
T
A
G
G
E
V
P
T
------------------
G
D
A
F
V
G
G
M
L
Y
T
F
A
Q
Q
F
DD
A
A
A
L
I
D
F
C
H
D
P
E
S
I
V
S
T
L
R
F
A
A
A
V
G
A
L
A
V
----
A
F
T
A
M
P
M
L
S
E
V
L
S
L
I
Q
E
Q
S
E
--------
9
PsiBlast_PDB
67.46
27%
-1
- C- -
2V78
-
KDGK_SULSO
A:
[2-312]
--
V
D
V
I
A
L
G
E
P
L
I
Q
F
N
S
F
N
P
G
P
L
-
R
-
F
V
N
Y
F
E
K
H
V
A
G
S
E
L
N
F
C
I
A
V
V
R
N
H
L
--
S
C
S
L
I
A
R
V
G
N
D
E
F
G
K
N
I
I
E
Y
S
R
A
Q
G
I
D
T
S
H
-
I
K
V
D
N
E
S
F
T
G
I
Y
F
----
I
Q
R
G
Y
P
IPM
K
S
E
L
V
Y
Y
-
R
K
G
S
A
-
G
S
R
L
S
P
E
--
D
I
N
E
N
Y
V
R
N
S
R
L
V
H
S
T
G
I
T
L
A
I
-
S
D
N
A
K
E
A
V
I
K
A
F
----
E
L
A
K
S
R
S
L
D
T
N
I
R
P
K
L
W
S
S
L
E
K
A
K
E
T
I
L
S
I
L
K
K
-
Y
D
I
E
V
L
I
T
D
P
D
D
T
K
I
L
L
D
V
T
D
--
P
D
E
A
Y
R
K
Y
K
E
L
G
V
K
V
L
L
Y
K
L
G
S
K
G
A
I
A
Y
K
D
N
V
K
A
F
K
D
A
Y
K
V
P
-------
V
E
D
P
T
G
A
G
D
A
M
A
G
T
F
V
S
L
Y
L
Q
G
K
--------------
D
I
E
Y
S
L
A
H
G
I
A
A
S
T
L
V
I
T
V
R
G
D
N
E
L
T
P
T
L
E
D
A
E
R
F
L
N
E
F
K
---------
64
HHSearch
67.05
26%
-60
- C1 -
1TYY
2
?
A:
[25-328]
--
N
K
V
W
V
I
G
D
A
S
V
D
L
V
P
E
K
Q
--------
N
S
Y
L
K
C
P
G
G
A
S
A
N
V
G
V
C
V
A
R
L
G
G
--
E
C
G
F
I
G
C
L
G
D
D
D
A
G
R
F
L
R
Q
V
F
Q
D
N
G
V
D
V
-
T
F
L
R
L
D
A
D
L
T
S
A
V
L
I
V
-
N
------------
S
F
T
Y
L
V
H
P
G
A
--
D
T
Y
V
S
P
Q
--
D
L
P
--
P
F
R
Q
Y
E
W
F
Y
F
S
S
I
G
L
T
--
D
R
P
A
R
E
A
C
L
E
G
A
R
R
M
R
E
A
G
G
Y
V
L
F
D
V
N
L
R
S
K
M
W
G
N
T
D
E
I
P
E
L
I
A
R
S
A
A
L
-
A
S
I
--
C
K
V
S
A
D
E
L
C
Q
L
S
G
A
S
H
--
W
Q
D
A
R
Y
Y
L
R
D
L
G
C
D
T
T
I
I
S
L
G
A
D
G
A
L
L
I
T
A
E
G
E
F
H
F
P
A
P
R
V
-------
D
V
V
D
T
T
G
A
G
D
A
F
V
G
G
L
L
F
T
L
S
R
A
N
CWD
H
A
---------
L
L
A
E
A
I
S
N
A
N
A
C
G
A
M
A
V
T
A
K
G
A
M
T
A
L
P
F
P
D
Q
L
N
T
F
L
S
------------
7
PsiBlast_PDB
66.06
27%
-4
- C1 -
2DCN
6
?
A:
[5-309]
-----
I
T
L
G
E
I
L
I
E
F
N
A
L
S
P
G
P
L
-
R
-
H
V
S
Y
F
E
K
H
V
A
G
S
E
A
N
Y
C
V
A
F
I
K
Q
G
N
--
E
C
G
I
I
A
K
V
G
D
D
E
F
G
Y
N
A
I
E
W
L
R
G
Q
G
V
D
V
S
H
-
M
K
I
D
P
S
A
P
T
G
I
F
F
----
I
Q
R
H
Y
P
VPL
K
S
E
S
I
Y
Y
-
R
K
G
S
A
-
G
S
K
L
S
P
E
--
D
V
D
E
E
Y
V
K
S
A
D
L
V
H
S
S
G
I
T
L
A
I
-
S
S
T
A
K
E
A
V
Y
K
A
F
E
I
A
S
N
R
----
S
F
D
T
N
I
R
L
K
L
W
S
A
E
E
A
K
R
E
I
L
K
L
L
S
K
F
H
L
K
F
--
L
I
T
D
T
D
D
S
K
I
I
L
G
E
S
D
--
P
D
K
A
A
K
A
F
-
S
D
Y
A
E
I
I
V
M
K
L
G
P
K
G
A
I
V
Y
Y
D
G
K
K
Y
Y
S
S
G
Y
Q
V
P
-------
V
E
D
V
T
G
A
G
D
A
L
G
G
T
F
L
S
L
Y
Y
K
G
F
--------------
E
M
E
K
A
L
D
Y
A
I
V
A
S
T
L
N
V
M
I
R
G
D
Q
E
N
L
P
T
T
K
D
I
E
T
F
L
R
E
M
----------
62
HHSearch
65.58
27%
3
- C1 -
3IQ0
2
?
A:
[4-313]
--
S
K
V
F
T
I
G
E
I
L
V
E
I
M
A
S
K
I
G
Q
P
F
D
Q
P
G
I
W
N
G
P
Y
P
S
G
A
P
A
I
F
I
D
Q
V
T
R
L
G
V
--
P
C
G
I
I
S
C
V
G
N
D
G
F
G
D
I
N
I
H
R
L
A
A
D
G
V
D
I
-
R
G
I
S
V
L
P
L
E
A
T
G
S
A
F
V
-
T
Y
H
N
---
R
-----
D
F
I
F
N
-
I
K
N
A
A
-
C
G
K
L
S
A
Q
--
H
V
D
E
N
I
L
K
D
C
T
H
F
H
I
M
G
S
S
L
F
--
S
F
H
M
V
D
A
V
K
K
A
V
T
I
V
K
A
N
G
G
V
I
S
F
D
P
N
I
R
K
E
M
L
D
I
P
-
E
M
R
D
A
L
H
F
V
L
E
L
-
T
D
I
--
Y
M
P
S
E
G
E
V
L
L
L
S
P
H
S
T
--
P
E
R
A
I
A
G
F
L
E
E
G
V
K
E
V
I
V
K
R
G
N
Q
G
A
S
Y
Y
S
A
N
E
Q
F
H
V
E
S
Y
P
V
-------
E
E
V
D
P
T
G
A
G
D
C
F
G
G
A
W
I
A
C
R
Q
L
G
F
--------------
D
A
H
R
A
L
Q
Y
A
N
A
C
G
A
L
A
V
T
R
R
G
P
M
E
G
T
S
R
L
M
E
I
E
T
F
I
Q
R
H
----------
8
PsiBlast_PDB
65.46
27%
0
- C1 -
1WYE
-
?
A:
[5-310]
-----
I
T
L
G
E
I
L
I
E
F
N
A
L
S
P
G
P
L
-
R
-
H
V
S
Y
F
E
K
H
V
A
G
S
E
A
N
Y
C
V
A
F
I
K
Q
G
N
--
E
C
G
I
I
A
K
V
G
D
D
E
F
G
Y
N
A
I
E
W
L
R
G
Q
G
V
D
V
S
H
-
M
K
I
D
P
S
A
P
T
G
I
F
F
----
I
Q
R
H
Y
P
VPL
K
S
E
S
I
Y
Y
-
R
K
G
S
A
-
G
S
K
L
S
P
E
--
D
V
D
E
E
Y
V
K
S
A
D
L
V
H
S
S
G
I
T
L
A
I
-
S
S
T
A
K
E
A
V
Y
K
A
F
E
I
A
S
N
R
----
S
F
D
T
N
I
R
L
K
L
W
S
A
E
E
A
K
R
E
I
L
K
L
L
S
K
F
H
L
K
F
--
L
I
T
D
T
D
D
S
K
I
I
L
G
E
S
D
--
P
D
K
A
A
K
A
F
-
S
D
Y
A
E
I
I
V
M
K
L
G
P
K
G
A
I
V
Y
Y
D
G
K
K
Y
Y
S
S
G
Y
Q
V
P
-------
V
E
D
V
T
G
A
G
D
A
L
G
G
T
F
L
S
L
Y
Y
K
G
F
--------------
E
M
E
K
A
L
D
Y
A
I
V
A
S
T
L
N
V
M
I
R
G
D
Q
E
N
L
P
T
T
K
D
I
E
T
F
L
R
E
M
K
---------
74
HHSearch
65.42
27%
-7
- C1 -
4E69
6
?
A:
[22-319]
S
M
M
H
I
L
S
I
G
E
C
M
A
E
L
A
P
A
D
-------
L
P
G
T
Y
R
L
G
F
A
G
D
T
F
N
T
A
W
Y
L
A
R
L
R
P
E
S
R
I
S
Y
F
S
A
I
G
D
D
A
L
S
Q
Q
M
R
A
A
M
S
A
A
G
I
D
G
-
G
G
L
R
V
I
P
G
R
T
V
G
L
Y
L
I
-
T
L
E
-
Q
G
E
R
-----
S
F
A
Y
W
-
R
-
G
Q
S
A
A
R
E
L
A
G
D
A
D
A
L
A
-
A
A
M
A
R
A
D
V
V
Y
F
S
G
I
T
L
A
I
L
D
Q
C
G
R
A
T
L
L
R
A
L
A
Q
A
R
A
T
G
R
T
I
A
F
D
P
N
L
R
P
R
L
W
A
G
T
G
E
M
T
E
T
I
M
Q
G
A
A
V
-
S
D
I
--
A
L
P
S
F
E
D
E
A
A
W
F
G
D
A
G
--
P
D
A
T
A
D
R
Y
A
R
A
G
V
R
S
V
V
V
K
N
G
P
H
A
V
H
F
L
Q
D
G
R
R
G
R
V
P
V
P
P
V
A
------
Q
V
V
D
T
T
A
A
G
D
S
F
N
A
G
L
L
D
S
V
L
A
G
Q
--------------
P
L
E
T
A
I
A
A
A
A
A
L
A
G
Q
V
V
Q
G
K
G
A
L
V
E
V
-----------------------