@TOME V2.3
(Nov 2016)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : bsu23080: (2016-07-06 )
MNVLTIKGVSIGEGMPKIIIPLMGKTEKQILNEAEAVKLLNPDIVEWRVDVFEKANDREAVTKLISKLRKSLEDKLFLFTFRTHKEGGSMEMDESSYLALLESAIQTKDIDLIDIELFSGDANVKALVSLAEENNVYVVMSNHDFEKTPVKDEIISRLRKMQDLGAHIPKMAVMPNDTGDLLTLLDATYTMKTIYADRPIITMSMAATGLISRLSGEVFGSACTFGAGEEASAPGQIPVSELRSVLDILHKNTRG
Atome Classification :
(51 SA)
.........10........20........30.....-...40........50........60........70-........80........90........100.......110.......120..---.....130.......140.......150.......160.......170.......180.......190.......200.......210.......220.......230.......240.......250...
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
M
N
V
L
T
I
KGVSIGEGM
P
K
I
I
I
PLMG
K
T
E
K
Q
I
L
N
E
A
E
A
-
V
KLLN
P
D
I
V
E
W
R
V
D
V
F
EKAN
D
R
E
A
V
T
K
L
I
S
K
L
R
K
S
-LED
K
L
F
L
F
T
F
R
THKEGGSMEMD
E
S
S
Y
L
A
L
L
E
S
A
IQTKD
I
D
L
I
D
I
E
L
FSGDA
N
V
---
K
A
L
V
S
LAEEN
N
V
Y
V
V
MSNHDFEKTP
V
K
D
E
I
I
S
R
L
R
K
M
Q
D
L
G
AHIP
K
M
A
VMPNDTG
D
L
L
T
L
LDA
T
Y
T
M
K
T
I
YADR
P
I
I
T
M
S
M
A
A
T
G
L
I
S
R
L
S
G
E
VFGSACTFGAGEEASAPGQI
P
V
S
E
L
R
S
V
L
D
I
L
HKNTRG
33
PsiBlast_CBE
89.18
54%
-107
- C4 -
3M7W
4
AROD_SALTY
B:
[5-254]
-
K
T
V
T
V
R
D
L
V
V
G
E
G
A
P
K
I
I
V
S
L
M
G
K
T
I
T
D
V
K
S
E
A
L
A
-
Y
R
E
A
D
F
D
I
L
E
W
R
V
D
H
F
A
N
V
T
T
A
E
S
V
L
E
A
A
G
A
I
R
E
I
-
I
T
D
K
P
L
L
F
T
F
R
S
A
K
E
G
G
E
Q
A
L
T
T
G
Q
Y
I
D
L
N
R
A
A
V
D
S
G
L
V
D
M
I
D
L
E
L
F
T
G
D
D
E
V
---
K
A
T
V
G
Y
A
H
Q
H
N
V
A
V
I
M
S
N
H
D
F
H
K
T
P
A
A
E
E
I
V
Q
R
L
R
K
M
Q
E
L
G
A
D
I
P
K
I
A
V
M
P
Q
T
K
A
D
V
L
T
L
L
T
A
T
V
E
M
Q
E
R
Y
A
D
R
P
I
I
T
M
S
M
S
K
T
G
V
I
S
R
L
A
G
E
V
F
G
S
A
A
T
F
G
A
V
K
K
A
S
A
P
G
Q
I
S
V
A
D
L
R
T
V
L
T
I
L
H
Q
----
45
PsiBlast_CBE
89.14
55%
-116
- C4 -
4CNP
5
AROD_SALTI
B:
[1-250]
M
K
T
V
T
V
K
N
L
I
I
G
E
G
M
P
K
I
I
V
S
L
M
G
R
D
I
N
S
V
K
A
E
A
L
A
-
Y
R
E
A
T
F
D
I
L
E
W
R
V
D
H
F
M
D
I
A
S
T
Q
S
V
L
T
A
A
R
V
I
R
D
A
-
M
P
D
I
P
L
L
F
T
F
R
S
A
K
E
G
G
E
Q
T
I
T
T
Q
H
Y
L
T
L
N
R
A
A
I
D
S
G
L
V
D
M
I
D
L
E
L
F
T
G
D
A
D
V
---
K
A
T
V
D
Y
A
H
A
H
N
V
Y
V
V
M
S
N
H
D
F
H
Q
T
P
S
A
E
E
M
V
L
R
L
R
K
M
Q
A
L
G
A
D
I
P
K
I
A
V
M
P
Q
S
K
H
D
V
L
T
L
L
T
A
T
L
E
M
Q
Q
H
Y
A
D
R
P
V
I
T
M
S
M
A
K
E
G
V
I
S
R
L
A
G
E
V
F
G
S
A
A
T
F
G
A
V
K
Q
A
S
A
P
G
Q
I
A
V
N
D
L
R
S
V
L
M
I
L
H
-----
46
PsiBlast_CBE
89.07
55%
-113
- C4 -
4CNP
5
AROD_SALTI
A:
[1-250]
M
K
T
V
T
V
K
N
L
I
I
G
E
G
M
P
K
I
I
V
S
L
M
G
R
D
I
N
S
V
K
A
E
A
L
A
-
Y
R
E
A
T
F
D
I
L
E
W
R
V
D
H
F
M
D
I
A
S
T
Q
S
V
L
T
A
A
R
V
I
R
D
A
-
M
P
D
I
P
L
L
F
T
F
R
S
A
K
E
G
G
E
Q
T
I
T
T
Q
H
Y
L
T
L
N
R
A
A
I
D
S
G
L
V
D
M
I
D
L
E
L
F
T
G
D
A
D
V
---
K
A
T
V
D
Y
A
H
A
H
N
V
Y
V
V
M
S
N
H
D
F
H
Q
T
P
S
A
E
E
M
V
L
R
L
R
K
M
Q
A
L
G
A
D
I
P
K
I
A
V
M
P
Q
S
K
H
D
V
L
T
L
L
T
A
T
L
E
M
Q
Q
H
Y
A
D
R
P
V
I
T
M
S
M
A
K
E
G
V
I
S
R
L
A
G
E
V
F
G
S
A
A
T
F
G
A
V
K
Q
A
S
A
P
G
Q
I
A
V
N
D
L
R
S
V
L
M
I
L
H
-----
23
PsiBlast_CBE
88.69
54%
-109
- C4 -
4GUJ
3
AROD_SALTY
B:
[5-254]
-
K
T
V
T
V
R
D
L
V
V
G
E
G
A
P
K
I
I
V
S
L
M
G
K
T
I
T
D
V
K
S
E
A
L
A
-
Y
R
E
A
D
F
D
I
L
E
W
R
V
D
H
F
A
N
V
T
T
A
E
S
V
L
E
A
A
G
A
I
R
E
I
-
I
T
D
K
P
L
L
F
T
F
R
S
A
K
E
G
G
E
Q
A
L
T
T
G
Q
Y
I
D
L
N
R
A
A
V
D
S
G
L
V
D
M
I
D
L
E
L
F
T
G
D
D
E
V
---
K
A
T
V
G
Y
A
H
Q
H
N
V
A
V
I
M
S
N
H
D
F
H
K
T
P
A
A
E
E
I
V
Q
R
L
R
K
M
Q
E
L
G
A
D
I
P
K
I
A
V
M
P
Q
T
K
A
D
V
L
T
L
L
T
A
T
V
E
M
Q
E
R
Y
A
D
R
P
I
I
T
M
S
M
S
K
T
G
V
I
S
R
L
A
G
E
V
F
G
S
A
A
T
F
G
A
V
K
K
A
S
A
P
G
Q
I
S
V
A
D
L
R
T
V
L
T
I
L
H
Q
----
26
PsiBlast_CBE
88.67
54%
-110
- C4 -
3OEX
1
AROD_SALTY
D:
[5-254]
-
K
T
V
T
V
R
D
L
V
V
G
E
G
A
P
K
I
I
V
S
L
M
G
K
T
I
T
D
V
K
S
E
A
L
A
-
Y
R
E
A
D
F
D
I
L
E
W
R
V
D
H
F
A
N
V
T
T
A
E
S
V
L
E
A
A
G
A
I
R
E
I
-
I
T
D
K
P
L
L
F
T
F
R
S
A
K
E
G
G
E
Q
A
L
T
T
G
Q
Y
I
D
L
N
R
A
A
V
D
S
G
L
V
D
M
I
D
L
E
L
F
T
G
D
D
E
V
---
K
A
T
V
G
Y
A
H
Q
H
N
V
A
V
I
M
S
N
H
D
F
H
K
T
P
A
A
E
E
I
V
Q
R
L
R
K
M
Q
E
L
G
A
D
I
P
K
I
A
V
M
P
Q
T
K
A
D
V
L
T
L
L
T
A
T
V
E
M
Q
E
R
Y
A
D
R
P
I
I
T
M
S
M
S
K
T
G
V
I
S
R
L
A
G
E
V
F
G
S
A
A
T
F
G
A
V
K
K
A
S
A
P
G
Q
I
S
V
A
D
L
R
T
V
L
T
I
L
H
Q
----
51
PsiBlast_CBE
88.66
55%
-114
- C4 -
4CLM
1
AROD_SALTI
B:
[2-250]
-
K
T
V
T
V
K
N
L
I
I
G
E
G
M
P
K
I
I
V
S
L
M
G
R
D
I
N
S
V
K
A
E
A
L
A
-
Y
R
E
A
T
F
D
I
L
E
W
R
V
D
H
F
M
D
I
A
S
T
Q
S
V
L
T
A
A
R
V
I
R
D
A
-
M
P
D
I
P
L
L
F
T
F
R
S
A
K
E
G
G
E
Q
T
I
T
T
Q
H
Y
L
T
L
N
R
A
A
I
D
S
G
L
V
D
M
I
D
L
E
L
F
T
G
D
A
D
V
---
K
A
T
V
D
Y
A
H
A
H
N
V
Y
V
V
M
S
N
H
D
F
H
Q
T
P
S
A
E
E
M
V
L
R
L
R
K
M
Q
A
L
G
A
D
I
P
K
I
A
V
M
P
Q
S
K
H
D
V
L
T
L
L
T
A
T
L
E
M
Q
Q
H
Y
A
D
R
P
V
I
T
M
S
M
A
K
E
G
V
I
S
R
L
A
G
E
V
F
G
S
A
A
T
F
G
A
V
K
Q
A
S
A
P
G
Q
I
A
V
N
D
L
R
S
V
L
M
I
L
H
-----
28
PsiBlast_CBE
88.52
54%
-106
- C4 -
3OEX
1
AROD_SALTY
B:
[4-254]
M
K
T
V
T
V
R
D
L
V
V
G
E
G
A
P
K
I
I
V
S
L
M
G
K
T
I
T
D
V
K
S
E
A
L
A
-
Y
R
E
A
D
F
D
I
L
E
W
R
V
D
H
F
A
N
V
T
T
A
E
S
V
L
E
A
A
G
A
I
R
E
I
-
I
T
D
K
P
L
L
F
T
F
R
S
A
K
E
G
G
E
Q
A
L
T
T
G
Q
Y
I
D
L
N
R
A
A
V
D
S
G
L
V
D
M
I
D
L
E
L
F
T
G
D
D
E
V
---
K
A
T
V
G
Y
A
H
Q
H
N
V
A
V
I
M
S
N
H
D
F
H
K
T
P
A
A
E
E
I
V
Q
R
L
R
K
M
Q
E
L
G
A
D
I
P
K
I
A
V
M
P
Q
T
K
A
D
V
L
T
L
L
T
A
T
V
E
M
Q
E
R
Y
A
D
R
P
I
I
T
M
S
M
S
K
T
G
V
I
S
R
L
A
G
E
V
F
G
S
A
A
T
F
G
A
V
K
K
A
S
A
P
G
Q
I
S
V
A
D
L
R
T
V
L
T
I
L
H
Q
----
44
PsiBlast_CBE
88.40
55%
-111
- C4 -
4UIO
5
AROD_SALTI
A:
[3-250]
--
T
V
T
V
K
N
L
I
I
G
E
G
M
P
K
I
I
V
S
L
M
G
R
D
I
N
S
V
K
A
E
A
L
A
-
Y
R
E
A
T
F
D
I
L
E
W
R
V
D
H
F
M
D
I
A
S
T
Q
S
V
L
T
A
A
R
V
I
R
D
A
-
M
P
D
I
P
L
L
F
T
F
R
S
A
K
E
G
G
E
Q
T
I
T
T
Q
H
Y
L
T
L
N
R
A
A
I
D
S
G
L
V
D
M
I
D
L
E
L
F
T
G
D
A
D
V
---
K
A
T
V
D
Y
A
H
A
H
N
V
Y
V
V
M
S
N
H
D
F
H
Q
T
P
S
A
E
E
M
V
L
R
L
R
K
M
Q
A
L
G
A
D
I
P
K
I
A
V
M
P
Q
S
K
H
D
V
L
T
L
L
T
A
T
L
E
M
Q
Q
H
Y
A
D
R
P
V
I
T
M
S
M
A
K
E
G
V
I
S
R
L
A
G
E
V
F
G
S
A
A
T
F
G
A
V
K
Q
A
S
A
P
G
Q
I
A
V
N
D
L
R
S
V
L
M
I
L
H
-----
41
PsiBlast_CBE
88.36
55%
-109
- C4 -
1L9W
1
AROD_SALTI
D:
[1-250]
M
K
T
V
T
V
K
N
L
I
I
G
E
G
M
P
K
I
I
V
S
L
M
G
R
D
I
N
S
V
K
A
E
A
L
A
-
Y
R
E
A
T
F
D
I
L
E
W
R
V
D
H
F
M
D
I
A
S
T
Q
S
V
L
T
A
A
R
V
I
R
D
A
-
M
P
D
I
P
L
L
F
T
F
R
S
A
K
E
G
G
E
Q
T
I
T
T
Q
H
Y
L
T
L
N
R
A
A
I
D
S
G
L
V
D
M
I
D
L
E
L
F
T
G
D
A
D
V
---
K
A
T
V
D
Y
A
H
A
H
N
V
Y
V
V
M
S
N
H
D
F
H
Q
T
P
S
A
E
E
M
V
S
R
L
R
K
M
Q
A
L
G
A
D
I
P
K
I
A
V
M
P
Q
S
K
H
D
V
L
T
L
L
T
A
T
L
E
M
Q
Q
H
Y
A
D
R
P
V
I
T
M
S
M
A
K
E
G
V
I
S
R
L
A
G
E
V
F
G
S
A
A
T
F
G
A
V
K
Q
A
S
A
P
G
Q
I
A
V
N
D
L
R
S
V
L
M
I
L
H
-----
6
PsiBlast_PDB
88.22
54%
-105
- C4 -
4GFS
2
AROD_SALTY
A:
[5-254]
-
K
T
V
T
V
R
D
L
V
V
G
E
G
A
P
K
I
I
V
S
L
M
G
K
T
I
T
D
V
K
S
E
A
L
A
-
Y
R
E
A
D
F
D
I
L
E
W
R
V
D
H
F
A
N
V
T
T
A
E
S
V
L
E
A
A
G
A
I
R
E
I
-
I
T
D
K
P
L
L
F
T
F
R
S
A
K
E
G
G
E
Q
A
L
T
T
G
Q
Y
I
D
L
N
R
A
A
V
D
S
G
L
V
D
M
I
D
L
E
L
F
T
G
D
D
E
V
---
K
A
T
V
G
Y
A
H
Q
H
N
V
A
V
I
M
S
N
H
D
F
H
K
T
P
A
A
E
E
I
V
Q
R
L
R
K
M
Q
E
L
G
A
D
I
P
K
I
A
V
M
P
Q
T
K
A
D
V
L
T
L
L
T
A
T
V
E
M
Q
E
R
Y
A
D
R
P
I
I
T
M
S
M
S
K
T
G
V
I
S
R
L
A
G
E
V
F
G
S
A
A
T
F
G
A
V
K
K
A
S
A
P
G
Q
I
S
V
A
D
L
R
T
V
L
T
I
L
H
Q
----
32
PsiBlast_CBE
88.07
54%
-102
- C4 -
3M7W
5
AROD_SALTY
C:
[5-254]
-
K
T
V
T
V
R
D
L
V
V
G
E
G
A
P
K
I
I
V
S
L
M
G
K
T
I
T
D
V
K
S
E
A
L
A
-
Y
R
E
A
D
F
D
I
L
E
W
R
V
D
H
F
A
N
V
T
T
A
E
S
V
L
E
A
A
G
A
I
R
E
I
-
I
T
D
K
P
L
L
F
T
F
R
S
A
K
E
G
G
E
Q
A
L
T
T
G
Q
Y
I
D
L
N
R
A
A
V
D
S
G
L
V
D
M
I
D
L
E
L
F
T
G
D
D
E
V
---
K
A
T
V
G
Y
A
H
Q
H
N
V
A
V
I
M
S
N
H
D
F
H
K
T
P
A
A
E
E
I
V
Q
R
L
R
K
M
Q
E
L
G
A
D
I
P
K
I
A
V
M
P
Q
T
K
A
D
V
L
T
L
L
T
A
T
V
E
M
Q
E
R
Y
A
D
R
P
I
I
T
M
S
M
S
K
T
G
V
I
S
R
L
A
G
E
V
F
G
S
A
A
T
F
G
A
V
K
K
A
S
A
P
G
Q
I
S
V
A
D
L
R
T
V
L
T
I
L
H
Q
----
21
PsiBlast_CBE
88.02
54%
-102
- C4 -
3S42
6
AROD_SALTY
B:
[25-275]
M
K
T
V
T
V
R
D
L
V
V
G
E
G
A
P
K
I
I
V
S
L
M
G
K
T
I
T
D
V
K
S
E
A
L
A
-
Y
R
E
A
D
F
D
I
L
E
W
R
V
D
H
F
A
N
V
T
T
A
E
S
V
L
E
A
A
G
A
I
R
E
I
-
I
T
D
K
P
L
L
F
T
F
R
S
A
K
E
G
G
E
Q
A
L
T
T
G
Q
Y
I
D
L
N
R
A
A
V
D
S
G
L
V
D
M
I
D
L
E
L
F
T
G
D
D
E
V
---
K
A
T
V
G
Y
A
H
Q
H
N
V
A
V
I
M
S
N
H
D
F
H
K
T
P
A
A
E
E
I
V
Q
R
L
R
K
M
Q
E
L
G
A
D
I
P
K
I
A
V
M
P
Q
T
K
A
D
V
L
T
L
L
T
A
T
V
E
M
Q
E
R
Y
A
D
R
P
I
I
T
M
S
M
S
K
T
G
V
I
S
R
L
A
G
E
V
F
G
S
A
A
T
F
G
A
V
K
K
A
S
A
P
G
Q
I
S
V
A
D
L
R
T
V
L
T
I
L
H
Q
----
17
PsiBlast_PDB
88.01
55%
-113
- C4 -
1GQN
-
AROD_SALTI
A:
[1-250]
M
K
T
V
T
V
K
N
L
I
I
G
E
G
M
P
K
I
I
V
S
L
M
G
R
D
I
N
S
V
K
A
E
A
L
A
-
Y
R
E
A
T
F
D
I
L
E
W
R
V
D
H
F
M
D
I
A
S
T
Q
S
V
L
T
A
A
R
V
I
R
D
A
-
M
P
D
I
P
L
L
F
T
F
R
S
A
K
E
G
G
E
Q
T
I
T
T
Q
H
Y
L
T
L
N
R
A
A
I
D
S
G
L
V
D
M
I
D
L
E
L
F
T
G
D
A
D
V
---
K
A
T
V
D
Y
A
H
A
H
N
V
Y
V
V
M
S
N
H
D
F
H
Q
T
P
S
A
E
E
M
V
S
R
L
R
K
M
Q
A
L
G
A
D
I
P
K
I
A
V
M
P
Q
S
K
H
D
V
L
T
L
L
T
A
T
L
E
M
Q
Q
H
Y
A
D
R
P
V
I
T
M
S
M
A
K
E
G
V
I
S
R
L
A
G
E
V
F
G
S
A
A
T
F
G
A
V
K
Q
A
S
A
P
G
Q
I
A
V
N
D
L
R
S
V
L
M
I
L
H
-----
30
PsiBlast_CBE
87.99
54%
-101
- C4 -
3M7W
4
AROD_SALTY
E:
[5-254]
-
K
T
V
T
V
R
D
L
V
V
G
E
G
A
P
K
I
I
V
S
L
M
G
K
T
I
T
D
V
K
S
E
A
L
A
-
Y
R
E
A
D
F
D
I
L
E
W
R
V
D
H
F
A
N
V
T
T
A
E
S
V
L
E
A
A
G
A
I
R
E
I
-
I
T
D
K
P
L
L
F
T
F
R
S
A
K
E
G
G
E
Q
A
L
T
T
G
Q
Y
I
D
L
N
R
A
A
V
D
S
G
L
V
D
M
I
D
L
E
L
F
T
G
D
D
E
V
---
K
A
T
V
G
Y
A
H
Q
H
N
V
A
V
I
M
S
N
H
D
F
H
K
T
P
A
A
E
E
I
V
Q
R
L
R
K
M
Q
E
L
G
A
D
I
P
K
I
A
V
M
P
Q
T
K
A
D
V
L
T
L
L
T
A
T
V
E
M
Q
E
R
Y
A
D
R
P
I
I
T
M
S
M
S
K
T
G
V
I
S
R
L
A
G
E
V
F
G
S
A
A
T
F
G
A
V
K
K
A
S
A
P
G
Q
I
S
V
A
D
L
R
T
V
L
T
I
L
H
Q
----
29
PsiBlast_CBE
87.86
54%
-103
- C4 -
3M7W
5
AROD_SALTY
F:
[5-254]
-
K
T
V
T
V
R
D
L
V
V
G
E
G
A
P
K
I
I
V
S
L
M
G
K
T
I
T
D
V
K
S
E
A
L
A
-
Y
R
E
A
D
F
D
I
L
E
W
R
V
D
H
F
A
N
V
T
T
A
E
S
V
L
E
A
A
G
A
I
R
E
I
-
I
T
D
K
P
L
L
F
T
F
R
S
A
K
E
G
G
E
Q
A
L
T
T
G
Q
Y
I
D
L
N
R
A
A
V
D
S
G
L
V
D
M
I
D
L
E
L
F
T
G
D
D
E
V
---
K
A
T
V
G
Y
A
H
Q
H
N
V
A
V
I
M
S
N
H
D
F
H
K
T
P
A
A
E
E
I
V
Q
R
L
R
K
M
Q
E
L
G
A
D
I
P
K
I
A
V
M
P
Q
T
K
A
D
V
L
T
L
L
T
A
T
V
E
M
Q
E
R
Y
A
D
R
P
I
I
T
M
S
M
S
K
T
G
V
I
S
R
L
A
G
E
V
F
G
S
A
A
T
F
G
A
V
K
K
A
S
A
P
G
Q
I
S
V
A
D
L
R
T
V
L
T
I
L
H
Q
----
8
PsiBlast_PDB
87.77
54%
-105
- C4 -
4GUJ
2
AROD_SALTY
A:
[5-254]
-
K
T
V
T
V
R
D
L
V
V
G
E
G
A
P
K
I
I
V
S
L
M
G
K
T
I
T
D
V
K
S
E
A
L
A
-
Y
R
E
A
D
F
D
I
L
E
W
R
V
D
H
F
A
N
V
T
T
A
E
S
V
L
E
A
A
G
A
I
R
E
I
-
I
T
D
K
P
L
L
F
T
F
R
S
A
K
E
G
G
E
Q
A
L
T
T
G
Q
Y
I
D
L
N
R
A
A
V
D
S
G
L
V
D
M
I
D
L
E
L
F
T
G
D
D
E
V
---
K
A
T
V
G
Y
A
H
Q
H
N
V
A
V
I
M
S
N
H
D
F
H
K
T
P
A
A
E
E
I
V
Q
R
L
R
K
M
Q
E
L
G
A
D
I
P
K
I
A
V
M
P
Q
T
K
A
D
V
L
T
L
L
T
A
T
V
E
M
Q
E
R
Y
A
D
R
P
I
I
T
M
S
M
S
K
T
G
V
I
S
R
L
A
G
E
V
F
G
S
A
A
T
F
G
A
V
K
K
A
S
A
P
G
Q
I
S
V
A
D
L
R
T
V
L
T
I
L
H
Q
----
24
PsiBlast_CBE
87.71
54%
-105
- C4 -
4GUI
5
AROD_SALTY
B:
[5-254]
-
K
T
V
T
V
R
D
L
V
V
G
E
G
A
P
K
I
I
V
S
L
M
G
K
T
I
T
D
V
K
S
E
A
L
A
-
Y
R
E
A
D
F
D
I
L
E
W
R
V
D
H
F
A
N
V
T
T
A
E
S
V
L
E
A
A
G
A
I
R
E
I
-
I
T
D
K
P
L
L
F
T
F
R
S
A
K
E
G
G
E
Q
A
L
T
T
G
Q
Y
I
D
L
N
R
A
A
V
D
S
G
L
V
D
M
I
D
L
E
L
F
T
G
D
D
E
V
---
K
A
T
V
G
Y
A
H
Q
H
N
V
A
V
I
M
S
N
H
D
F
H
K
T
P
A
A
E
E
I
V
Q
R
L
R
K
M
Q
E
L
G
A
D
I
P
K
I
A
V
M
P
Q
T
K
A
D
V
L
T
L
L
T
A
T
V
E
M
Q
E
R
Y
A
D
R
P
I
I
T
M
S
M
S
K
T
G
V
I
S
R
L
A
G
E
V
F
G
S
A
A
T
F
G
A
V
K
K
A
S
A
P
G
Q
I
S
V
A
D
L
R
T
V
L
T
I
L
H
Q
----
42
PsiBlast_CBE
87.67
55%
-110
- C4 -
1L9W
1
AROD_SALTI
C:
[1-250]
M
K
T
V
T
V
K
N
L
I
I
G
E
G
M
P
K
I
I
V
S
L
M
G
R
D
I
N
S
V
K
A
E
A
L
A
-
Y
R
E
A
T
F
D
I
L
E
W
R
V
D
H
F
M
D
I
A
S
T
Q
S
V
L
T
A
A
R
V
I
R
D
A
-
M
P
D
I
P
L
L
F
T
F
R
S
A
K
E
G
G
E
Q
T
I
T
T
Q
H
Y
L
T
L
N
R
A
A
I
D
S
G
L
V
D
M
I
D
L
E
L
F
T
G
D
A
D
V
---
K
A
T
V
D
Y
A
H
A
H
N
V
Y
V
V
M
S
N
H
D
F
H
Q
T
P
S
A
E
E
M
V
S
R
L
R
K
M
Q
A
L
G
A
D
I
P
K
I
A
V
M
P
Q
S
K
H
D
V
L
T
L
L
T
A
T
L
E
M
Q
Q
H
Y
A
D
R
P
V
I
T
M
S
M
A
K
E
G
V
I
S
R
L
A
G
E
V
F
G
S
A
A
T
F
G
A
V
K
Q
A
S
A
P
G
Q
I
A
V
N
D
L
R
S
V
L
M
I
L
H
-----
65
Fugue
87.66
55%
-112
- C4 -
1QFE
1
AROD_SALTI
A:
[1-252]
M
K
T
V
T
V
K
N
L
I
I
G
E
G
M
P
K
I
I
V
S
L
M
G
R
D
I
N
S
V
K
A
E
A
L
A
-
Y
R
E
A
T
F
D
I
L
E
W
R
V
D
H
F
M
D
I
A
S
T
Q
S
V
L
T
A
A
R
V
I
R
D
A
-
M
P
D
I
P
L
L
F
T
F
R
S
A
K
E
G
G
E
Q
T
I
T
T
Q
H
Y
L
T
L
N
R
A
A
I
D
S
G
L
V
D
M
I
D
L
E
L
F
T
G
D
A
D
V
---
K
A
T
V
D
Y
A
H
A
H
N
V
Y
V
V
M
S
N
H
D
F
H
Q
T
P
S
A
E
E
M
V
S
R
L
R
K
M
Q
A
L
G
A
D
I
P
K
I
A
V
M
P
Q
S
K
H
D
V
L
T
L
L
T
A
T
L
E
M
Q
Q
H
Y
A
D
R
P
V
I
T
M
S
M
A
K
E
G
V
I
S
R
L
A
G
E
V
F
G
S
A
A
T
F
G
A
V
K
Q
A
S
A
P
G
Q
I
A
V
N
D
L
R
S
V
L
M
I
L
H
N
A
---
15
PsiBlast_PDB
87.63
55%
-113
- C4 -
1QFE
1
AROD_SALTI
A:
[1-250]
M
K
T
V
T
V
K
N
L
I
I
G
E
G
M
P
K
I
I
V
S
L
M
G
R
D
I
N
S
V
K
A
E
A
L
A
-
Y
R
E
A
T
F
D
I
L
E
W
R
V
D
H
F
M
D
I
A
S
T
Q
S
V
L
T
A
A
R
V
I
R
D
A
-
M
P
D
I
P
L
L
F
T
F
R
S
A
K
E
G
G
E
Q
T
I
T
T
Q
H
Y
L
T
L
N
R
A
A
I
D
S
G
L
V
D
M
I
D
L
E
L
F
T
G
D
A
D
V
---
K
A
T
V
D
Y
A
H
A
H
N
V
Y
V
V
M
S
N
H
D
F
H
Q
T
P
S
A
E
E
M
V
S
R
L
R
K
M
Q
A
L
G
A
D
I
P
K
I
A
V
M
P
Q
S
K
H
D
V
L
T
L
L
T
A
T
L
E
M
Q
Q
H
Y
A
D
R
P
V
I
T
M
S
M
A
K
E
G
V
I
S
R
L
A
G
E
V
F
G
S
A
A
T
F
G
A
V
K
Q
A
S
A
P
G
Q
I
A
V
N
D
L
R
S
V
L
M
I
L
H
-----
47
PsiBlast_CBE
87.60
55%
-111
- C4 -
4CNO
1
AROD_SALTI
D:
[2-250]
-
K
T
V
T
V
K
N
L
I
I
G
E
G
M
P
K
I
I
V
S
L
M
G
R
D
I
N
S
V
K
A
E
A
L
A
-
Y
R
E
A
T
F
D
I
L
E
W
R
V
D
H
F
M
D
I
A
S
T
Q
S
V
L
T
A
A
R
V
I
R
D
A
-
M
P
D
I
P
L
L
F
T
F
R
S
A
K
E
G
G
E
Q
T
I
T
T
Q
H
Y
L
T
L
N
R
A
A
I
D
S
G
L
V
D
M
I
D
L
E
L
F
T
G
D
A
D
V
---
K
A
T
V
D
Y
A
H
A
H
N
V
Y
V
V
M
S
N
H
D
F
H
Q
T
P
S
A
E
E
M
V
L
R
L
R
K
M
Q
A
L
G
A
D
I
P
K
I
A
V
M
P
Q
S
K
H
D
V
L
T
L
L
T
A
T
L
E
M
Q
Q
H
Y
A
D
R
P
V
I
T
M
S
M
A
K
E
G
V
I
S
R
L
A
G
E
V
F
G
S
A
A
T
F
G
A
V
K
----
P
G
Q
I
A
V
N
D
L
R
S
V
L
M
I
L
H
-----
39
PsiBlast_CBE
87.59
53%
-109
- C4 -
3NNT
1
AROD_SALTY
B:
[25-275]
M
K
T
V
T
V
R
D
L
V
V
G
E
G
A
P
K
I
I
V
S
L
M
G
K
T
I
T
D
V
K
S
E
A
L
A
-
Y
R
E
A
D
F
D
I
L
E
W
R
V
D
H
F
A
N
V
T
T
A
E
S
V
L
E
A
A
G
A
I
R
E
I
-
I
T
D
K
P
L
L
F
T
F
R
S
A
K
E
G
G
E
Q
A
L
T
T
G
Q
Y
I
D
L
N
R
A
A
V
D
S
G
L
V
D
M
I
D
L
E
L
F
T
G
D
D
E
V
---
K
A
T
V
G
Y
A
H
Q
H
N
V
A
V
I
M
S
N
H
D
F
H
K
T
P
A
A
E
E
I
V
Q
R
L
R
K
M
Q
E
L
G
A
D
I
P
M
I
A
V
M
P
Q
T
K
A
D
V
L
T
L
L
T
A
T
V
E
M
Q
E
R
Y
A
D
R
P
I
I
T
M
S
M
S
K
T
G
V
I
S
R
L
A
G
E
V
F
G
S
A
A
T
F
G
A
V
K
K
A
S
A
P
G
Q
I
S
V
A
D
L
R
T
V
L
T
I
L
H
Q
----
48
PsiBlast_CBE
87.53
55%
-112
- C4 -
4CNO
1
AROD_SALTI
C:
[1-250]
M
K
T
V
T
V
K
N
L
I
I
G
E
G
M
P
K
I
I
V
S
L
M
G
R
D
I
N
S
V
K
A
E
A
L
A
-
Y
R
E
A
T
F
D
I
L
E
W
R
V
D
H
F
M
D
I
A
S
T
Q
S
V
L
T
A
A
R
V
I
R
D
A
-
M
P
D
I
P
L
L
F
T
F
R
S
A
K
E
G
G
E
Q
T
I
T
T
Q
H
Y
L
T
L
N
R
A
A
I
D
S
G
L
V
D
M
I
D
L
E
L
F
T
G
D
A
D
V
---
K
A
T
V
D
Y
A
H
A
H
N
V
Y
V
V
M
S
N
H
D
F
H
Q
T
P
S
A
E
E
M
V
L
R
L
R
K
M
Q
A
L
G
A
D
I
P
K
I
A
V
M
P
Q
S
K
H
D
V
L
T
L
L
T
A
T
L
E
M
Q
Q
H
Y
A
D
R
P
V
I
T
M
S
M
A
K
E
G
V
I
S
R
L
A
G
E
V
F
G
S
A
A
T
F
G
A
V
K
----
P
G
Q
I
A
V
N
D
L
R
S
V
L
M
I
L
H
-----
43
PsiBlast_CBE
87.52
55%
-108
- C4 -
1L9W
1
AROD_SALTI
B:
[1-250]
M
K
T
V
T
V
K
N
L
I
I
G
E
G
M
P
K
I
I
V
S
L
M
G
R
D
I
N
S
V
K
A
E
A
L
A
-
Y
R
E
A
T
F
D
I
L
E
W
R
V
D
H
F
M
D
I
A
S
T
Q
S
V
L
T
A
A
R
V
I
R
D
A
-
M
P
D
I
P
L
L
F
T
F
R
S
A
K
E
G
G
E
Q
T
I
T
T
Q
H
Y
L
T
L
N
R
A
A
I
D
S
G
L
V
D
M
I
D
L
E
L
F
T
G
D
A
D
V
---
K
A
T
V
D
Y
A
H
A
H
N
V
Y
V
V
M
S
N
H
D
F
H
Q
T
P
S
A
E
E
M
V
S
R
L
R
K
M
Q
A
L
G
A
D
I
P
K
I
A
V
M
P
Q
S
K
H
D
V
L
T
L
L
T
A
T
L
E
M
Q
Q
H
Y
A
D
R
P
V
I
T
M
S
M
A
K
E
G
V
I
S
R
L
A
G
E
V
F
G
S
A
A
T
F
G
A
V
K
Q
A
S
A
P
G
Q
I
A
V
N
D
L
R
S
V
L
M
I
L
H
-----
16
PsiBlast_PDB
87.47
55%
-107
- C4 -
1L9W
1
AROD_SALTI
A:
[1-250]
M
K
T
V
T
V
K
N
L
I
I
G
E
G
M
P
K
I
I
V
S
L
M
G
R
D
I
N
S
V
K
A
E
A
L
A
-
Y
R
E
A
T
F
D
I
L
E
W
R
V
D
H
F
M
D
I
A
S
T
Q
S
V
L
T
A
A
R
V
I
R
D
A
-
M
P
D
I
P
L
L
F
T
F
R
S
A
K
E
G
G
E
Q
T
I
T
T
Q
H
Y
L
T
L
N
R
A
A
I
D
S
G
L
V
D
M
I
D
L
E
L
F
T
G
D
A
D
V
---
K
A
T
V
D
Y
A
H
A
H
N
V
Y
V
V
M
S
N
H
D
F
H
Q
T
P
S
A
E
E
M
V
S
R
L
R
K
M
Q
A
L
G
A
D
I
P
K
I
A
V
M
P
Q
S
K
H
D
V
L
T
L
L
T
A
T
L
E
M
Q
Q
H
Y
A
D
R
P
V
I
T
M
S
M
A
K
E
G
V
I
S
R
L
A
G
E
V
F
G
S
A
A
T
F
G
A
V
K
Q
A
S
A
P
G
Q
I
A
V
N
D
L
R
S
V
L
M
I
L
H
-----
25
PsiBlast_CBE
87.45
54%
-112
- C4 -
4GFS
5
AROD_SALTY
B:
[4-254]
M
K
T
V
T
V
R
D
L
V
V
G
E
G
A
P
K
I
I
V
S
L
M
G
K
T
I
T
D
V
K
S
E
A
L
A
-
Y
R
E
A
D
F
D
I
L
E
W
R
V
D
H
F
A
N
V
T
T
A
E
S
V
L
E
A
A
G
A
I
R
E
I
-
I
T
D
K
P
L
L
F
T
F
R
S
A
K
E
G
G
E
Q
A
L
T
T
G
Q
Y
I
D
L
N
R
A
A
V
D
S
G
L
V
D
M
I
D
L
E
L
F
T
G
D
D
E
V
---
K
A
T
V
G
Y
A
H
Q
H
N
V
A
V
I
M
S
N
H
D
F
H
K
T
P
A
A
E
E
I
V
Q
R
L
R
K
M
Q
E
L
G
A
D
I
P
K
I
A
V
M
P
Q
T
K
A
D
V
L
T
L
L
T
A
T
V
E
M
Q
E
R
Y
A
D
R
P
I
I
T
M
S
M
S
K
T
G
V
I
S
R
L
A
G
E
V
F
G
S
A
A
T
F
G
A
V
K
---
A
P
G
Q
I
S
V
A
D
L
R
T
V
L
T
I
L
H
Q
----
50
PsiBlast_CBE
87.43
55%
-119
- C4 -
4CNN
4
AROD_SALTI
B:
[2-250]
-
K
T
V
T
V
K
N
L
I
I
G
E
G
M
P
K
I
I
V
S
L
M
G
R
D
I
N
S
V
K
A
E
A
L
A
-
Y
R
E
A
T
F
D
I
L
E
W
R
V
D
H
F
M
D
I
A
S
T
Q
S
V
L
T
A
A
R
V
I
R
D
A
-
M
P
D
I
P
L
L
F
T
F
R
S
A
K
E
G
G
E
Q
T
I
T
T
Q
H
Y
L
T
L
N
R
A
A
I
D
S
G
L
V
D
M
I
D
L
E
L
F
T
G
D
A
D
V
---
K
A
T
V
D
Y
A
H
A
H
N
V
Y
V
V
M
S
N
H
D
F
H
Q
T
P
S
A
E
E
M
V
L
R
L
R
K
M
Q
A
L
G
A
D
I
P
K
I
A
V
M
P
Q
S
K
H
D
V
L
T
L
L
T
A
T
L
E
M
Q
Q
H
Y
A
D
R
P
V
I
T
M
S
M
A
K
E
G
V
I
S
R
L
A
G
E
V
F
G
S
A
A
T
F
G
A
V
K
----
P
G
Q
I
A
V
N
D
L
R
S
V
L
M
I
L
H
-----
13
PsiBlast_PDB
87.42
53%
-106
- C4 -
3NNT
1
AROD_SALTY
A:
[25-275]
M
K
T
V
T
V
R
D
L
V
V
G
E
G
A
P
K
I
I
V
S
L
M
G
K
T
I
T
D
V
K
S
E
A
L
A
-
Y
R
E
A
D
F
D
I
L
E
W
R
V
D
H
F
A
N
V
T
T
A
E
S
V
L
E
A
A
G
A
I
R
E
I
-
I
T
D
K
P
L
L
F
T
F
R
S
A
K
E
G
G
E
Q
A
L
T
T
G
Q
Y
I
D
L
N
R
A
A
V
D
S
G
L
V
D
M
I
D
L
E
L
F
T
G
D
D
E
V
---
K
A
T
V
G
Y
A
H
Q
H
N
V
A
V
I
M
S
N
H
D
F
H
K
T
P
A
A
E
E
I
V
Q
R
L
R
K
M
Q
E
L
G
A
D
I
P
M
I
A
V
M
P
Q
T
K
A
D
V
L
T
L
L
T
A
T
V
E
M
Q
E
R
Y
A
D
R
P
I
I
T
M
S
M
S
K
T
G
V
I
S
R
L
A
G
E
V
F
G
S
A
A
T
F
G
A
V
K
K
A
S
A
P
G
Q
I
S
V
A
D
L
R
T
V
L
T
I
L
H
Q
----
11
PsiBlast_PDB
87.37
53%
-107
- C4 -
4GUH
1
AROD_SALTY
A:
[25-275]
M
K
T
V
T
V
R
D
L
V
V
G
E
G
A
P
K
I
I
V
S
L
M
G
K
T
I
T
D
V
K
S
E
A
L
A
-
Y
R
E
A
D
F
D
I
L
E
W
R
V
D
H
F
A
N
V
T
T
A
E
S
V
L
E
A
A
G
A
I
R
E
I
-
I
T
D
K
P
L
L
F
T
F
R
S
A
K
A
G
G
E
Q
A
L
T
T
G
Q
Y
I
D
L
N
R
A
A
V
D
S
G
L
V
D
M
I
D
L
E
L
F
T
G
D
D
E
V
---
K
A
T
V
G
Y
A
H
Q
H
N
V
A
V
I
M
S
N
H
D
F
H
K
T
P
A
A
E
E
I
V
Q
R
L
R
K
M
Q
E
L
G
A
D
I
P
K
I
A
V
M
P
Q
T
K
A
D
V
L
T
L
L
T
A
T
V
E
M
Q
E
R
Y
A
D
R
P
I
I
T
M
S
M
S
K
T
G
V
I
S
R
L
A
G
E
V
F
G
S
A
A
T
F
G
A
V
K
K
A
S
A
P
G
Q
I
S
V
A
D
L
R
T
V
L
T
I
L
H
Q
----
2
PsiBlast_PDB
87.34
54%
-99
- C4 -
3LB0
2
AROD_SALTY
A:
[25-275]
M
K
T
V
T
V
R
D
L
V
V
G
E
G
A
P
K
I
I
V
S
L
M
G
K
T
I
T
D
V
K
S
E
A
L
A
-
Y
R
E
A
D
F
D
I
L
E
W
R
V
D
H
F
A
N
V
T
T
A
E
S
V
L
E
A
A
G
A
I
R
E
I
-
I
T
D
K
P
L
L
F
T
F
R
S
A
K
E
G
G
E
Q
A
L
T
T
G
Q
Y
I
D
L
N
R
A
A
V
D
S
G
L
V
D
M
I
D
L
E
L
F
T
G
D
D
E
V
---
K
A
T
V
G
Y
A
H
Q
H
N
V
A
V
I
M
S
N
H
D
F
H
K
T
P
A
A
E
E
I
V
Q
R
L
R
K
M
Q
E
L
G
A
D
I
P
K
I
A
V
M
P
Q
T
K
A
D
V
L
T
L
L
T
A
T
V
E
M
Q
E
R
Y
A
D
R
P
I
I
T
M
S
M
S
K
T
G
V
I
S
R
L
A
G
E
V
F
G
S
A
A
T
F
G
A
V
K
K
A
S
A
P
G
Q
I
S
V
A
D
L
R
T
V
L
T
I
L
H
Q
----
7
PsiBlast_PDB
87.29
54%
-105
- C4 -
4GUI
3
AROD_SALTY
A:
[5-254]
-
K
T
V
T
V
R
D
L
V
V
G
E
G
A
P
K
I
I
V
S
L
M
G
K
T
I
T
D
V
K
S
E
A
L
A
-
Y
R
E
A
D
F
D
I
L
E
W
R
V
D
H
F
A
N
V
T
T
A
E
S
V
L
E
A
A
G
A
I
R
E
I
-
I
T
D
K
P
L
L
F
T
F
R
S
A
K
E
G
G
E
Q
A
L
T
T
G
Q
Y
I
D
L
N
R
A
A
V
D
S
G
L
V
D
M
I
D
L
E
L
F
T
G
D
D
E
V
---
K
A
T
V
G
Y
A
H
Q
H
N
V
A
V
I
M
S
N
H
D
F
H
K
T
P
A
A
E
E
I
V
Q
R
L
R
K
M
Q
E
L
G
A
D
I
P
K
I
A
V
M
P
Q
T
K
A
D
V
L
T
L
L
T
A
T
V
E
M
Q
E
R
Y
A
D
R
P
I
I
T
M
S
M
S
K
T
G
V
I
S
R
L
A
G
E
V
F
G
S
A
A
T
F
G
A
V
K
K
A
S
A
P
G
Q
I
S
V
A
D
L
R
T
V
L
T
I
L
H
Q
----
38
PsiBlast_CBE
87.15
53%
-105
- C4 -
4IUO
1
AROD_SALTY
B:
[25-275]
M
K
T
V
T
V
R
D
L
V
V
G
E
G
A
P
K
I
I
V
S
L
M
G
K
T
I
T
D
V
K
S
E
A
L
A
-
Y
R
E
A
D
F
D
I
L
E
W
R
V
D
H
F
A
N
V
T
T
A
E
S
V
L
E
A
A
G
A
I
R
E
I
-
I
T
D
K
P
L
L
F
T
F
R
S
A
K
E
G
G
E
Q
A
L
T
T
G
Q
Y
I
D
L
N
R
A
A
V
D
S
G
L
V
D
M
I
D
L
E
L
F
T
G
D
D
E
V
---
K
A
T
V
G
Y
A
H
Q
H
N
V
A
V
I
M
S
N
H
D
F
H
K
T
P
A
A
E
E
I
V
Q
R
L
R
K
M
Q
E
L
G
A
D
I
P
M
I
A
V
M
P
Q
T
K
A
D
V
L
T
L
L
T
A
T
V
E
M
Q
E
R
Y
A
D
R
P
I
I
T
M
S
M
S
K
T
G
V
I
S
R
L
A
G
E
V
F
G
S
A
A
T
F
G
A
V
K
K
A
S
A
P
G
Q
I
S
V
A
D
L
R
T
V
L
T
I
L
H
Q
----
40
PsiBlast_CBE
87.14
55%
-111
- C4 -
1QFE
1
AROD_SALTI
B:
[1-250]
M
K
T
V
T
V
K
N
L
I
I
G
E
G
M
P
K
I
I
V
S
L
M
G
R
D
I
N
S
V
K
A
E
A
L
A
-
Y
R
E
A
T
F
D
I
L
E
W
R
V
D
H
F
M
D
I
A
S
T
Q
S
V
L
T
A
A
R
V
I
R
D
A
-
M
P
D
I
P
L
L
F
T
F
R
S
A
K
E
G
G
E
Q
T
I
T
T
Q
H
Y
L
T
L
N
R
A
A
I
D
S
G
L
V
D
M
I
D
L
E
L
F
T
G
D
A
D
V
---
K
A
T
V
D
Y
A
H
A
H
N
V
Y
V
V
M
S
N
H
D
F
H
Q
T
P
S
A
E
E
M
V
S
R
L
R
K
M
Q
A
L
G
A
D
I
P
K
I
A
V
M
P
Q
S
K
H
D
V
L
T
L
L
T
A
T
L
E
M
Q
Q
H
Y
A
D
R
P
V
I
T
M
S
M
A
K
E
G
V
I
S
R
L
A
G
E
V
F
G
S
A
A
T
F
G
A
V
K
Q
A
S
A
P
G
Q
I
A
V
N
D
L
R
S
V
L
M
I
L
H
-----
18
PsiBlast_PDB
87.13
55%
-119
- C4 -
4CNO
1
AROD_SALTI
A:
[2-250]
-
K
T
V
T
V
K
N
L
I
I
G
E
G
M
P
K
I
I
V
S
L
M
G
R
D
I
N
S
V
K
A
E
A
L
A
-
Y
R
E
A
T
F
D
I
L
E
W
R
V
D
H
F
M
D
I
A
S
T
Q
S
V
L
T
A
A
R
V
I
R
D
A
-
M
P
D
I
P
L
L
F
T
F
R
S
A
K
E
G
G
E
Q
T
I
T
T
Q
H
Y
L
T
L
N
R
A
A
I
D
S
G
L
V
D
M
I
D
L
E
L
F
T
G
D
A
D
V
---
K
A
T
V
D
Y
A
H
A
H
N
V
Y
V
V
M
S
N
H
D
F
H
Q
T
P
S
A
E
E
M
V
L
R
L
R
K
M
Q
A
L
G
A
D
I
P
K
I
A
V
M
P
Q
S
K
H
D
V
L
T
L
L
T
A
T
L
E
M
Q
Q
H
Y
A
D
R
P
V
I
T
M
S
M
A
K
E
G
V
I
S
R
L
A
G
E
V
F
G
S
A
A
T
F
G
A
V
K
----
P
G
Q
I
A
V
N
D
L
R
S
V
L
M
I
L
H
-----
14
PsiBlast_PDB
87.03
53%
-107
- C4 -
4IUO
1
AROD_SALTY
A:
[25-275]
M
K
T
V
T
V
R
D
L
V
V
G
E
G
A
P
K
I
I
V
S
L
M
G
K
T
I
T
D
V
K
S
E
A
L
A
-
Y
R
E
A
D
F
D
I
L
E
W
R
V
D
H
F
A
N
V
T
T
A
E
S
V
L
E
A
A
G
A
I
R
E
I
-
I
T
D
K
P
L
L
F
T
F
R
S
A
K
E
G
G
E
Q
A
L
T
T
G
Q
Y
I
D
L
N
R
A
A
V
D
S
G
L
V
D
M
I
D
L
E
L
F
T
G
D
D
E
V
---
K
A
T
V
G
Y
A
H
Q
H
N
V
A
V
I
M
S
N
H
D
F
H
K
T
P
A
A
E
E
I
V
Q
R
L
R
K
M
Q
E
L
G
A
D
I
P
M
I
A
V
M
P
Q
T
K
A
D
V
L
T
L
L
T
A
T
V
E
M
Q
E
R
Y
A
D
R
P
I
I
T
M
S
M
S
K
T
G
V
I
S
R
L
A
G
E
V
F
G
S
A
A
T
F
G
A
V
K
K
A
S
A
P
G
Q
I
S
V
A
D
L
R
T
V
L
T
I
L
H
Q
----
49
PsiBlast_CBE
86.82
55%
-116
- C4 -
4CNO
1
AROD_SALTI
B:
[2-250]
-
K
T
V
T
V
K
N
L
I
I
G
E
G
M
P
K
I
I
V
S
L
M
G
R
D
I
N
S
V
K
A
E
A
L
A
-
Y
R
E
A
T
F
D
I
L
E
W
R
V
D
H
F
M
D
I
A
S
T
Q
S
V
L
T
A
A
R
V
I
R
D
A
-
M
P
D
I
P
L
L
F
T
F
R
S
A
K
E
G
G
E
Q
T
I
T
T
Q
H
Y
L
T
L
N
R
A
A
I
D
S
G
L
V
D
M
I
D
L
E
L
F
T
G
D
A
D
V
---
K
A
T
V
D
Y
A
H
A
H
N
V
Y
V
V
M
S
N
H
D
F
H
Q
T
P
S
A
E
E
M
V
L
R
L
R
K
M
Q
A
L
G
A
D
I
P
K
I
A
V
M
P
Q
S
K
H
D
V
L
T
L
L
T
A
T
L
E
M
Q
Q
H
Y
A
D
R
P
V
I
T
M
S
M
A
K
E
G
V
I
S
R
L
A
G
E
V
F
G
S
A
A
T
F
G
A
V
K
----
P
G
Q
I
A
V
N
D
L
R
S
V
L
M
I
L
H
-----
57
PsiBlast_CBE
86.55
50%
-119
- C4 -
3JS3
1
AROD_PEPD6
C:
[8-256]
---
V
Q
V
K
N
I
T
I
G
E
G
R
P
K
I
C
V
P
I
I
G
K
N
K
K
D
I
I
K
E
A
K
E
-
L
K
D
A
C
L
D
I
I
E
W
R
V
D
F
F
E
N
V
E
N
I
K
E
V
K
E
V
L
Y
E
L
R
S
Y
-
I
H
D
I
P
L
L
F
T
F
R
S
V
V
E
G
G
E
K
L
I
S
R
D
Y
Y
T
T
L
N
K
E
I
S
N
T
G
L
V
D
L
I
D
V
E
L
F
M
G
D
E
V
I
---
D
E
V
V
N
F
A
H
K
K
E
V
K
V
I
I
S
N
H
D
F
N
K
T
P
K
K
E
E
I
V
S
R
L
C
R
M
Q
E
L
G
A
D
L
P
K
I
A
V
M
P
Q
N
E
K
D
V
L
V
L
L
E
A
T
N
E
M
F
K
I
Y
A
D
R
P
I
I
T
M
S
M
S
G
M
G
V
I
S
R
L
C
G
E
I
F
G
S
A
L
T
F
G
A
A
K
S
V
S
A
P
G
Q
I
S
F
K
E
L
N
S
V
L
N
L
L
H
K
S
---
10
PsiBlast_PDB
86.14
53%
-111
- C4 -
4GUG
2
AROD_SALTY
A:
[25-275]
M
K
T
V
T
V
R
D
L
V
V
G
E
G
A
P
K
I
I
V
S
L
M
G
K
T
I
T
D
V
K
S
E
A
L
A
-
Y
R
E
A
D
F
D
I
L
E
W
R
V
D
H
F
A
N
V
T
T
A
E
S
V
L
E
A
A
G
A
I
R
E
I
-
I
T
D
K
P
L
L
F
T
F
R
S
A
K
A
G
G
E
Q
A
L
T
T
G
Q
Y
I
D
L
N
R
A
A
V
D
S
G
L
V
D
M
I
D
L
E
L
F
T
G
D
D
E
V
---
K
A
T
V
G
Y
A
H
Q
H
N
V
A
V
I
M
S
N
H
D
F
H
K
T
P
A
A
E
E
I
V
Q
R
L
R
K
M
Q
E
L
G
A
D
I
P
K
I
A
V
M
P
Q
T
K
A
D
V
L
T
L
L
T
A
T
V
E
M
Q
E
R
Y
A
D
R
P
I
I
T
M
S
M
S
K
T
G
V
I
S
R
L
A
G
E
V
F
G
S
A
A
T
F
G
A
V
K
----
P
G
Q
I
S
V
A
D
L
R
T
V
L
T
I
L
H
Q
----
34
PsiBlast_CBE
86.13
53%
-103
- C4 -
4GUH
2
AROD_SALTY
B:
[25-275]
M
K
T
V
T
V
R
D
L
V
V
G
E
G
A
P
K
I
I
V
S
L
M
G
K
T
I
T
D
V
K
S
E
A
L
A
-
Y
R
E
A
D
F
D
I
L
E
W
R
V
D
H
F
A
N
V
T
T
A
E
S
V
L
E
A
A
G
A
I
R
E
I
-
I
T
D
K
P
L
L
F
T
F
R
S
A
K
A
G
G
E
Q
A
L
T
T
G
Q
Y
I
D
L
N
R
A
A
V
D
S
G
L
V
D
M
I
D
L
E
L
F
T
G
D
D
E
V
---
K
A
T
V
G
Y
A
H
Q
H
N
V
A
V
I
M
S
N
H
D
F
H
K
T
P
A
A
E
E
I
V
Q
R
L
R
K
M
Q
E
L
G
A
D
I
P
K
I
A
V
M
P
Q
T
K
A
D
V
L
T
L
L
T
A
T
V
E
M
Q
E
R
Y
A
D
R
P
I
I
T
M
S
M
S
K
T
G
V
I
S
R
L
A
G
E
V
F
G
S
A
A
T
F
G
A
V
K
K
A
S
A
P
G
Q
I
S
V
A
D
L
R
T
V
L
T
I
L
H
Q
----
56
PsiBlast_CBE
85.92
50%
-115
- C4 -
3JS3
1
AROD_PEPD6
D:
[8-256]
---
V
Q
V
K
N
I
T
I
G
E
G
R
P
K
I
C
V
P
I
I
G
K
N
K
K
D
I
I
K
E
A
K
E
-
L
K
D
A
C
L
D
I
I
E
W
R
V
D
F
F
E
N
V
E
N
I
K
E
V
K
E
V
L
Y
E
L
R
S
Y
-
I
H
D
I
P
L
L
F
T
F
R
S
V
V
E
G
G
E
K
L
I
S
R
D
Y
Y
T
T
L
N
K
E
I
S
N
T
G
L
V
D
L
I
D
V
E
L
F
M
G
D
E
V
I
---
D
E
V
V
N
F
A
H
K
K
E
V
K
V
I
I
S
N
H
D
F
N
K
T
P
K
K
E
E
I
V
S
R
L
C
R
M
Q
E
L
G
A
D
L
P
K
I
A
V
M
P
Q
N
E
K
D
V
L
V
L
L
E
A
T
N
E
M
F
K
I
Y
A
D
R
P
I
I
T
M
S
M
S
G
M
G
V
I
S
R
L
C
G
E
I
F
G
S
A
L
T
F
G
A
A
K
S
V
S
A
P
G
Q
I
S
F
K
E
L
N
S
V
L
N
L
L
H
K
S
---
35
PsiBlast_CBE
85.71
53%
-116
- C4 -
4GUG
1
AROD_SALTY
B:
[27-275]
--
T
V
T
V
R
D
L
V
V
G
E
G
A
P
K
I
I
V
S
L
M
G
K
T
I
T
D
V
K
S
E
A
L
A
-
Y
R
E
A
D
F
D
I
L
E
W
R
V
D
H
F
A
N
V
T
T
A
E
S
V
L
E
A
A
G
A
I
R
E
I
-
I
T
D
K
P
L
L
F
T
F
R
S
A
----
E
Q
A
L
T
T
G
Q
Y
I
D
L
N
R
A
A
V
D
S
G
L
V
D
M
I
D
L
E
L
F
T
G
D
D
E
V
---
K
A
T
V
G
Y
A
H
Q
H
N
V
A
V
I
M
S
N
H
D
F
H
K
T
P
A
A
E
E
I
V
Q
R
L
R
K
M
Q
E
L
G
A
D
I
P
K
I
A
V
M
P
Q
T
K
A
D
V
L
T
L
L
T
A
T
V
E
M
Q
E
R
Y
A
D
R
P
I
I
T
M
S
M
S
K
T
G
V
I
S
R
L
A
G
E
V
F
G
S
A
A
T
F
G
A
V
K
K
A
S
A
P
G
Q
I
S
V
A
D
L
R
T
V
L
T
I
L
H
Q
----
59
PsiBlast_CBE
85.70
50%
-114
- C4 -
3JS3
1
AROD_PEPD6
A:
[8-256]
---
V
Q
V
K
N
I
T
I
G
E
G
R
P
K
I
C
V
P
I
I
G
K
N
K
K
D
I
I
K
E
A
K
E
-
L
K
D
A
C
L
D
I
I
E
W
R
V
D
F
F
E
N
V
E
N
I
K
E
V
K
E
V
L
Y
E
L
R
S
Y
-
I
H
D
I
P
L
L
F
T
F
R
S
V
V
E
G
G
E
K
L
I
S
R
D
Y
Y
T
T
L
N
K
E
I
S
N
T
G
L
V
D
L
I
D
V
E
L
F
M
G
D
E
V
I
---
D
E
V
V
N
F
A
H
K
K
E
V
K
V
I
I
S
N
H
D
F
N
K
T
P
K
K
E
E
I
V
S
R
L
C
R
M
Q
E
L
G
A
D
L
P
K
I
A
V
M
P
Q
N
E
K
D
V
L
V
L
L
E
A
T
N
E
M
F
K
I
Y
A
D
R
P
I
I
T
M
S
M
S
G
M
G
V
I
S
R
L
C
G
E
I
F
G
S
A
L
T
F
G
A
A
K
S
V
S
A
P
G
Q
I
S
F
K
E
L
N
S
V
L
N
L
L
H
K
S
---
54
PsiBlast_CBE
85.59
50%
-122
- C4 -
4H3D
3
AROD_PEPD6
B:
[8-256]
---
V
Q
V
K
N
I
T
I
G
E
G
R
P
K
I
C
V
P
I
I
G
K
N
K
K
D
I
I
K
E
A
K
E
-
L
K
D
A
C
L
D
I
I
E
W
R
V
D
F
F
E
N
V
E
N
I
K
E
V
K
E
V
L
Y
E
L
R
S
Y
-
I
H
D
I
P
L
L
F
T
F
R
S
V
V
E
G
G
E
K
L
I
S
R
D
Y
Y
T
T
L
N
K
E
I
S
N
T
G
L
V
D
L
I
D
V
E
L
F
M
G
D
E
V
I
---
D
E
V
V
N
F
A
H
K
K
E
V
K
V
I
I
S
N
H
D
F
N
K
T
P
K
K
E
E
I
V
S
R
L
C
R
M
Q
E
L
G
A
D
L
P
K
I
A
V
M
P
Q
N
E
K
D
V
L
V
L
L
E
A
T
N
E
M
F
K
I
Y
A
D
R
P
I
I
T
M
S
M
S
G
M
G
V
I
S
R
L
C
G
E
I
F
G
S
A
L
T
F
G
A
A
K
S
V
S
A
P
G
Q
I
S
F
K
E
L
N
S
V
L
N
L
L
H
K
S
---
52
PsiBlast_CBE
85.35
50%
-123
- C4 -
4H3D
3
AROD_PEPD6
D:
[8-256]
---
V
Q
V
K
N
I
T
I
G
E
G
R
P
K
I
C
V
P
I
I
G
K
N
K
K
D
I
I
K
E
A
K
E
-
L
K
D
A
C
L
D
I
I
E
W
R
V
D
F
F
E
N
V
E
N
I
K
E
V
K
E
V
L
Y
E
L
R
S
Y
-
I
H
D
I
P
L
L
F
T
F
R
S
V
V
E
G
G
E
K
L
I
S
R
D
Y
Y
T
T
L
N
K
E
I
S
N
T
G
L
V
D
L
I
D
V
E
L
F
M
G
D
E
V
I
---
D
E
V
V
N
F
A
H
K
K
E
V
K
V
I
I
S
N
H
D
F
N
K
T
P
K
K
E
E
I
V
S
R
L
C
R
M
Q
E
L
G
A
D
L
P
K
I
A
V
M
P
Q
N
E
K
D
V
L
V
L
L
E
A
T
N
E
M
F
K
I
Y
A
D
R
P
I
I
T
M
S
M
S
G
M
G
V
I
S
R
L
C
G
E
I
F
G
S
A
L
T
F
G
A
A
K
--
S
A
P
G
Q
I
S
F
K
E
L
N
S
V
L
N
L
L
H
K
S
---
58
PsiBlast_CBE
85.12
50%
-116
- C4 -
3JS3
1
AROD_PEPD6
B:
[8-256]
---
V
Q
V
K
N
I
T
I
G
E
G
R
P
K
I
C
V
P
I
I
G
K
N
K
K
D
I
I
K
E
A
K
E
-
L
K
D
A
C
L
D
I
I
E
W
R
V
D
F
F
E
N
V
E
N
I
K
E
V
K
E
V
L
Y
E
L
R
S
Y
-
I
H
D
I
P
L
L
F
T
F
R
S
V
V
E
G
G
E
K
L
I
S
R
D
Y
Y
T
T
L
N
K
E
I
S
N
T
G
L
V
D
L
I
D
V
E
L
F
M
G
D
E
V
I
---
D
E
V
V
N
F
A
H
K
K
E
V
K
V
I
I
S
N
H
D
F
N
K
T
P
K
K
E
E
I
V
S
R
L
C
R
M
Q
E
L
G
A
D
L
P
K
I
A
V
M
P
Q
N
E
K
D
V
L
V
L
L
E
A
T
N
E
M
F
K
I
Y
A
D
R
P
I
I
T
M
S
M
S
G
M
G
V
I
S
R
L
C
G
E
I
F
G
S
A
L
T
F
G
A
A
K
S
V
S
A
P
G
Q
I
S
F
K
E
L
N
S
V
L
N
L
L
H
K
S
---
55
PsiBlast_CBE
82.95
50%
-123
- C4 -
4H3D
3
AROD_PEPD6
A:
[8-256]
---
V
Q
V
K
N
I
T
I
G
E
G
R
P
K
I
C
V
P
I
I
G
K
N
K
K
D
I
I
K
E
A
K
E
-
L
K
D
A
C
L
D
I
I
E
W
R
V
D
F
F
E
N
V
E
N
I
K
E
V
K
E
V
L
Y
E
L
R
S
Y
-
I
H
D
I
P
L
L
F
T
F
R
S
V
V
E
G
G
E
K
L
I
S
R
D
Y
Y
T
T
L
N
K
E
I
S
N
T
G
L
V
D
L
I
D
V
E
L
F
M
G
D
E
V
I
---
D
E
V
V
N
F
A
H
K
K
E
V
K
V
I
I
S
N
H
D
F
N
K
T
P
K
K
E
E
I
V
S
R
L
C
R
M
Q
E
L
G
A
D
L
P
K
I
A
V
M
P
Q
N
E
K
D
V
L
V
L
L
E
A
T
N
E
M
F
K
I
Y
A
D
R
P
I
I
T
M
S
M
S
G
M
G
V
I
S
R
L
C
G
E
I
F
G
S
A
L
T
F
G
A
A
K
---
A
P
G
Q
I
S
F
K
E
L
N
S
V
L
N
L
L
H
K
S
---
53
PsiBlast_CBE
82.91
50%
-122
- C4 -
4H3D
2
AROD_PEPD6
C:
[8-256]
---
V
Q
V
K
N
I
T
I
G
E
G
R
P
K
I
C
V
P
I
I
G
K
N
K
K
D
I
I
K
E
A
K
E
-
L
K
D
A
C
L
D
I
I
E
W
R
V
D
F
F
E
N
V
E
N
I
K
E
V
K
E
V
L
Y
E
L
R
S
Y
-
I
H
D
I
P
L
L
F
T
F
R
S
V
V
E
G
G
E
K
L
I
S
R
D
Y
Y
T
T
L
N
K
E
I
S
N
T
G
L
V
D
L
I
D
V
E
L
F
M
G
D
E
V
I
---
D
E
V
V
N
F
A
H
K
K
E
V
K
V
I
I
S
N
H
D
F
N
K
T
P
K
K
E
E
I
V
S
R
L
C
R
M
Q
E
L
G
A
D
L
P
K
I
A
V
M
P
Q
N
E
K
D
V
L
V
L
L
E
A
T
N
E
M
F
K
I
Y
A
D
R
P
I
I
T
M
S
M
S
G
M
G
V
I
S
R
L
C
G
E
I
F
G
S
A
L
T
F
G
A
A
K
---
A
P
G
Q
I
S
F
K
E
L
N
S
V
L
N
L
L
H
K
S
---
3
PsiBlast_PDB
77.22
54%
-97
- C4 -
3S42
6
AROD_SALTY
A:
[25-275]
M
K
T
V
T
V
R
D
L
V
V
G
E
G
A
P
K
I
I
V
S
L
M
G
K
T
I
T
D
V
K
S
E
A
L
A
-
Y
R
E
A
D
F
D
I
L
E
W
R
V
D
H
F
A
N
V
T
T
A
E
S
V
L
E
A
A
G
A
I
R
E
I
-
I
T
D
K
P
L
L
F
T
F
R
S
A
K
E
G
G
E
Q
A
L
T
T
G
Q
Y
I
D
L
N
R
A
A
V
D
S
G
L
V
D
M
I
D
L
E
L
F
T
G
D
D
E
V
---
K
A
T
V
G
Y
A
H
Q
H
N
V
A
V
I
M
S
N
H
D
F
H
K
T
P
A
A
E
E
I
V
Q
R
L
R
K
M
Q
E
L
G
A
D
I
P
K
I
A
V
M
P
Q
T
K
A
D
V
L
T
L
L
T
A
T
V
E
M
Q
E
R
Y
A
D
R
P
I
I
T
M
S
M
S
K
T
G
V
I
S
R
L
A
G
E
V
F
G
S
A
A
T
F
G
A
V
K
K
A
S
A
P
G
Q
I
S
V
A
D
L
R
T
V
L
T
I
L
H
Q
----
78
HHSearch
75.14
50%
-5
- C4 -
4H3D
3
AROD_PEPD6
A:
[6-257]
-
R
K
V
Q
V
K
N
I
T
I
G
E
G
R
P
K
I
C
V
P
I
I
G
K
N
K
K
D
I
I
K
E
A
K
E
L
K
D
A
-
C
L
D
I
I
E
W
R
V
D
F
F
E
N
V
E
N
I
K
E
V
K
E
V
L
Y
E
L
R
S
Y
I
H
D
-
I
P
L
L
F
T
F
R
S
V
V
E
G
G
E
K
L
I
S
R
D
Y
Y
T
T
L
N
K
E
I
S
N
T
G
L
V
D
L
I
D
V
E
L
F
M
G
D
E
V
I
---
D
E
V
V
N
F
A
H
K
K
E
V
K
V
I
I
S
N
H
D
F
N
K
T
P
K
K
E
E
I
V
S
R
L
C
R
M
Q
E
L
G
A
D
L
P
K
I
A
V
M
P
Q
N
E
K
D
V
L
V
L
L
E
A
T
N
E
M
F
K
I
Y
A
D
R
P
I
I
T
M
S
M
S
G
M
G
V
I
S
R
L
C
G
E
I
F
G
S
A
L
T
F
G
A
A
K
---
A
P
G
Q
I
S
F
K
E
L
N
S
V
L
N
L
L
H
K
S
I
--
60
PsiBlast_CBE
63.15
35%
-64
- C4 -
1SFJ
1
AROD_STAAR
B:
[32-233]
-------------------------------------------
D
V
L
E
L
R
I
D
Q
F
E
N
V
T
-
V
D
Q
V
A
E
M
I
T
K
L
----
Q
D
S
F
K
L
L
V
T
Y
R
T
K
L
Q
G
G
Y
G
Q
F
T
N
D
S
Y
L
N
L
I
S
D
L
A
N
I
N
G
I
D
M
I
D
I
E
-
W
Q
A
D
I
D
I
E
K
H
Q
R
I
I
T
H
L
Q
Q
Y
N
K
E
V
I
I
S
H
H
N
F
E
S
T
P
P
L
D
E
L
Q
F
I
F
F
K
M
Q
K
F
N
P
E
Y
V
K
L
A
V
M
P
H
N
K
N
D
V
L
N
L
L
Q
A
M
S
T
F
S
D
T
-
M
D
C
K
V
V
G
I
S
M
S
K
L
G
L
I
S
R
T
A
Q
G
V
F
G
G
A
L
T
Y
G
C
I
G
E
P
Q
A
P
G
Q
I
D
V
T
D
L
K
A
-----------
61
PsiBlast_CBE
62.65
35%
-60
- C4 -
1SFJ
1
AROD_STAAR
A:
[32-233]
-------------------------------------------
D
V
L
E
L
R
I
D
Q
F
E
N
V
T
-
V
D
Q
V
A
E
M
I
T
K
L
------
S
F
K
L
L
V
T
Y
R
T
K
L
Q
G
G
Y
G
Q
F
T
N
D
S
Y
L
N
L
I
S
D
L
A
N
I
N
G
I
D
M
I
D
I
E
-
W
Q
A
D
I
D
I
E
K
H
Q
R
I
I
T
H
L
Q
Q
Y
N
K
E
V
I
I
S
H
H
N
F
E
S
T
P
P
L
D
E
L
Q
F
I
F
F
K
M
Q
K
F
N
P
E
Y
V
K
L
A
V
M
P
H
N
K
N
D
V
L
N
L
L
Q
A
M
S
T
F
S
D
T
-
M
D
C
K
V
V
G
I
S
M
S
K
L
G
L
I
S
R
T
A
Q
G
V
F
G
G
A
L
T
Y
G
C
I
G
E
P
Q
A
P
G
Q
I
D
V
T
D
L
K
A
-----------