@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : bsu23870: (2016-07-07 )
MPGKSRIIFHIDMNSFYASVEMAYDPALRGKPVAVAGNVKERKGIVVTCSYEARARGVKTTMPVWQAKRHCPELIVLPPNFDRYRNSSRAMFTILREYTDLVEPVSIDEGYMDMTDTPYSSRALETAKEIQSRLQKELLLPSSIGIAPNKFLAKMASDMKKPLGITILRKRQVPDILWPLPVGEMHGVGKKTAEKLKGLGIHTIGELAAADEHSLKRLLGINGPRLKNKANGIHHAPVDPERIYEFKSVGNSSTLSHDSSDEEELLGVFRKLAASVSDRLQRKEVMASKLFIMIRYADWRTITRSTTLRNPIDQKNDILKEAEHLFFKHWNKNPVRLLGITGTDLVEKEQAYKQLDLFSFNEDAKDEPIQQMMEKLNKKYGTKLIRKGATLKKEESKTKGTSFNKDFFQDEKKS
Atome Classification :
(75 SA)
.........10........20........30.....--.--..40........50........60........70.......-------.80........90.-.......100.......110......-.-----120-.----------------------------------------------------.......130.......140.......150.......160.......170.......180.......190..-.....200.......210.......220.-...-....230.......240.......250......--.260.......270.......280-..----.--.....290.......300---.......--310.......320......---.330........340.......350.......360.......370.......380.......390.......400.......410..
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MPGK
S
R
I
I
F
H
ID
M
N
S
F
Y
A
S
V
E
M
AYDPALRGK
P
V
A
V
A--G--NVKERK
G
I
V
V
T
C
S
Y
E
ARARGVKTTM
P
V
W
Q
A
KRHCP
E
L
I
V
LP-------P
N
F
D
R
YRNS
S
R
A
M
F
-
T
I
L
R
E
Y
T
D
LVEPVSIDEGYMDMTDTP-Y-----S-
S
-
R
----------------------------------------------------
A
L
E
T
A
K
E
I
Q
S
R
L
Q
K
E
LLLPSSIGIA
P
N
K
F
L
A
K
M
A
S
D
M
KKPL
G
I
T
I
L
RKRQVPDILWPLP
V
G
E
MHGV
G
K
K
T
A
E
-
K
L
KGLGI
H
T
I
G
E
L
AAA
D
E
H
S
L
K
R
L
LG-IN-GPR-LKNKANGIHHAPV
D
P
E
R
I
Y
E
F
K
SVGNSSTLSHD--SS
D
E
E
E
L
L
G
V
F
R
K
L
A
A
S
V
S
D
R
L
Q
--
R
K
----
E
--
V
M
A
S
K
L
F
I
M
I
R
YAD
W
R
T
I---TRSTTLR--NPID
Q
K
N
D
I
L
K
E
A
E
H
L
F
F
K
---HW-NKNP
V
R
L
L
GITG
T
D
L
V
E
K
E
Q
A
Y
K
QL
D
L
F
SFNEDAK
D
E
P
I
Q
Q
M
M
E
K
L
N
K
K
Y
G
T
K
L
I
RKGATLKKEESKTKGTSF
N
K
D
F
F
Q
DEKKS
6
PsiBlast_PDB
71.02
35%
-16
- C3 -
4IR1
5
DPO4_ECOLI
F:
[2-340]
----
S
R
K
I
I
H
V
D
M
D
C
F
F
A
A
V
E
M
R
D
N
P
A
L
R
D
I
P
I
A
I
G
--
G
--
S
-
R
E
R
R
G
V
I
S
T
A
N
Y
P
A
R
K
F
G
V
R
S
A
M
P
T
G
M
A
L
K
L
C
P
H
L
T
L
L
P
-------
G
R
F
D
A
Y
K
E
A
S
N
H
I
R
-
E
I
F
S
R
Y
T
S
R
I
E
P
L
S
L
D
E
A
Y
L
D
V
T
D
S
V
-
H
-----
C
H
G
-
S
----------------------------------------------------
A
T
L
I
A
Q
E
I
R
Q
T
I
F
N
E
L
Q
L
T
A
S
A
G
V
A
P
V
K
F
L
A
K
I
A
S
D
M
N
K
P
N
G
Q
F
V
I
T
P
A
E
V
P
A
F
L
Q
T
L
P
L
A
K
I
P
G
V
G
K
V
S
A
A
-
K
L
E
A
M
G
L
R
T
C
G
D
V
Q
K
C
D
L
V
M
L
L
K
R
F
G
-
K
F
-
G
R
I
-
L
W
E
R
S
Q
G
I
D
E
R
D
V
N
S
E
R
L
R
--
K
S
V
G
V
E
R
T
M
A
E
D
--
I
H
H
W
S
E
C
E
A
I
I
E
R
L
Y
P
E
L
E
R
R
L
A
KV
K
P
----
D
--
L
L
I
A
R
Q
G
V
K
L
K
F
D
D
F
Q
Q
T
---
T
Q
E
H
V
W
----
P
R
L
N
K
A
D
L
I
A
T
A
R
K
T
W
D
E
---
R
R
-
G
G
R
G
V
R
L
V
G
L
H
V
T
L
L
---------------------------------------------------------------------
3
PsiBlast_PDB
69.82
35%
-12
- C3 -
4IRK
6
DPO4_ECOLI
B:
[2-340]
----
S
R
K
I
I
H
V
D
M
D
C
F
F
A
A
V
E
M
R
D
N
P
A
L
R
D
I
P
I
A
I
G
--
G
--
S
-
R
E
R
R
G
V
I
S
T
A
N
Y
P
A
R
K
F
G
V
R
S
A
M
P
T
G
M
A
L
A
L
C
P
H
L
T
L
L
P
-------
G
R
F
D
A
Y
K
E
A
S
N
H
I
R
-
E
I
F
S
R
Y
T
S
R
I
E
P
L
S
L
D
E
A
Y
L
D
V
T
D
S
V
-
H
-----
C
H
G
-
S
----------------------------------------------------
A
T
L
I
A
Q
E
I
R
Q
T
I
F
N
E
L
Q
L
T
A
S
A
G
V
A
P
V
K
F
L
A
K
I
A
S
D
M
N
K
P
N
G
Q
F
V
I
T
P
A
E
V
P
A
F
L
Q
T
L
P
L
A
K
I
P
G
V
G
K
V
S
A
A
-
K
L
E
A
M
G
L
R
T
C
G
D
V
Q
A
C
D
L
V
M
L
L
K
R
F
G
-
K
F
-
G
R
I
-
L
W
E
R
S
Q
G
I
D
E
R
D
V
N
S
E
R
L
R
--
K
S
V
G
V
E
R
T
M
A
E
D
--
I
H
H
W
S
E
C
E
A
I
I
E
R
L
Y
P
E
L
E
R
R
L
A
KV
K
P
----
D
--
L
L
I
A
R
Q
G
V
K
L
K
F
D
D
F
Q
Q
T
---
T
Q
E
H
V
W
----
P
R
L
N
K
A
D
L
I
A
T
A
R
K
T
W
D
E
---
R
R
-
G
G
R
G
V
R
L
V
G
L
H
V
T
L
L
---------------------------------------------------------------------
23
PsiBlast_CBE
69.62
35%
-13
- C3 -
4IRK
4
DPO4_ECOLI
A:
[2-340]
----
S
R
K
I
I
H
V
D
M
D
C
F
F
A
A
V
E
M
R
D
N
P
A
L
R
D
I
P
I
A
I
G
--
G
--
S
-
R
E
R
R
G
V
I
S
T
A
N
Y
P
A
R
K
F
G
V
R
S
A
M
P
T
G
M
A
L
A
L
C
P
H
L
T
L
L
P
-------
G
R
F
D
A
Y
K
E
A
S
N
H
I
R
-
E
I
F
S
R
Y
T
S
R
I
E
P
L
S
L
D
E
A
Y
L
D
V
T
D
S
V
-
H
-----
C
H
G
-
S
----------------------------------------------------
A
T
L
I
A
Q
E
I
R
Q
T
I
F
N
E
L
Q
L
T
A
S
A
G
V
A
P
V
K
F
L
A
K
I
A
S
D
M
N
K
P
N
G
Q
F
V
I
T
P
A
E
V
P
A
F
L
Q
T
L
P
L
A
K
I
P
G
V
G
K
V
S
A
A
-
K
L
E
A
M
G
L
R
T
C
G
D
V
Q
A
C
D
L
V
M
L
L
K
R
F
G
-
K
F
-
G
R
I
-
L
W
E
R
S
Q
G
I
D
E
R
D
V
N
S
E
R
L
R
--
K
S
V
G
V
E
R
T
M
A
E
D
--
I
H
H
W
S
E
C
E
A
I
I
E
R
L
Y
P
E
L
E
R
R
L
A
K
V
K
P
----
D
--
L
L
I
A
R
Q
G
V
K
L
K
F
D
D
F
Q
Q
T
---
T
Q
E
H
V
W
----
P
R
L
N
K
A
D
L
I
A
T
A
R
K
T
W
D
E
---
R
R
-
G
G
R
G
V
R
L
V
G
L
H
V
T
L
L
---------------------------------------------------------------------
26
PsiBlast_CBE
69.60
35%
-13
- C3 -
4Q43
5
DPO4_ECOLI
F:
[2-340]
----
S
R
K
I
I
H
V
D
M
D
C
F
F
A
A
V
E
M
R
D
N
P
A
L
R
D
I
P
I
A
I
G
--
G
--
S
-
R
E
R
R
G
V
I
S
T
A
N
Y
P
A
R
K
F
G
V
R
S
A
M
P
T
G
M
A
L
K
L
C
P
H
L
T
L
L
P
-------
G
R
F
D
A
Y
K
E
A
S
N
H
I
R
-
E
I
F
S
R
Y
T
S
R
I
E
P
L
S
L
D
E
A
Y
L
D
V
T
D
S
V
-
H
-----
C
H
G
-
S
----------------------------------------------------
A
T
L
I
A
Q
E
I
R
Q
T
I
F
N
E
L
Q
L
T
A
S
A
G
V
A
P
V
K
F
L
A
K
I
A
S
D
M
N
K
P
N
G
Q
F
V
I
T
P
A
E
V
P
A
F
L
Q
T
L
P
L
A
K
I
P
G
V
G
K
V
S
A
A
-
K
L
E
A
M
G
L
R
T
C
G
D
V
Q
K
C
D
L
V
M
L
L
K
R
F
G
-
K
F
-
G
R
I
-
L
W
E
R
S
Q
G
I
D
E
R
D
V
N
S
E
R
L
R
--
K
S
V
G
V
E
R
T
M
A
E
D
--
I
H
H
W
S
E
C
E
A
I
I
E
R
L
Y
P
E
L
E
R
R
L
A
KV
K
P
----
D
--
L
L
I
A
R
Q
G
V
K
L
K
F
D
D
F
Q
Q
T
---
T
Q
E
H
V
W
----
P
R
L
N
K
A
D
L
I
A
T
A
R
K
T
W
D
E
---
R
R
-
G
G
R
G
V
R
L
V
G
L
H
V
T
L
L
---------------------------------------------------------------------
5
PsiBlast_PDB
69.32
35%
-14
- C3 -
4Q45
5
DPO4_ECOLI
F:
[2-340]
----
S
R
K
I
I
H
V
D
M
D
C
F
F
A
A
V
E
M
R
D
N
P
A
L
R
D
I
P
I
A
I
G
--
G
--
S
-
R
E
R
R
G
V
I
S
T
A
N
Y
P
A
R
K
F
G
V
R
S
A
M
P
T
G
M
A
L
A
L
C
P
H
L
T
L
L
P
-------
G
R
F
D
A
Y
K
E
A
S
N
H
I
R
-
E
I
F
S
R
Y
T
S
R
I
E
P
L
S
L
D
E
A
Y
L
D
V
T
D
S
V
-
H
-----
C
H
G
-
S
----------------------------------------------------
A
T
L
I
A
Q
E
I
R
Q
T
I
F
N
E
L
Q
L
T
A
S
A
G
V
A
P
V
K
F
L
A
K
I
A
S
D
M
N
K
P
N
G
Q
F
V
I
T
P
A
E
V
P
A
F
L
Q
T
L
P
L
A
K
I
P
G
V
G
K
V
S
A
A
-
K
L
E
A
M
G
L
R
T
C
G
D
V
Q
A
C
D
L
V
M
L
L
K
R
F
G
-
K
F
-
G
R
I
-
L
W
E
R
S
Q
G
I
D
E
R
D
V
N
S
E
R
L
R
--
K
S
V
G
V
E
R
T
M
A
E
D
--
I
H
H
W
S
E
C
E
A
I
I
E
R
L
Y
P
E
L
E
R
R
L
A
KV
K
P
----
D
--
L
L
I
A
R
Q
G
V
K
L
K
F
D
D
F
Q
Q
T
---
T
Q
E
H
V
W
----
P
R
L
N
K
A
D
L
I
A
T
A
R
K
T
W
D
E
---
R
R
-
G
G
R
G
V
R
L
V
G
L
H
V
T
L
L
---------------------------------------------------------------------
9
PsiBlast_PDB
69.27
35%
-12
- C3 -
4R8U
4
DPO4_ECOLI
A:
[1-339]
----
S
R
K
I
I
H
V
D
M
D
C
F
F
A
A
V
E
M
R
D
N
P
A
L
R
D
I
P
I
A
I
G
--
G
--
S
-
R
E
R
R
G
V
I
S
T
A
N
Y
P
A
R
K
F
G
V
R
S
A
M
P
T
G
M
A
L
K
L
C
P
H
L
T
L
L
P
-------
G
R
F
D
A
Y
K
E
A
S
N
H
I
R
-
E
I
F
S
R
Y
T
S
R
I
E
P
L
S
L
D
E
A
Y
L
D
V
T
D
S
V
-
H
-----
C
H
G
-
S
----------------------------------------------------
A
T
L
I
A
Q
E
I
R
Q
T
I
F
N
E
L
Q
L
T
A
S
A
G
V
A
P
V
K
F
L
A
K
I
A
S
D
M
N
K
P
N
G
Q
F
V
I
T
P
A
E
V
P
A
F
L
Q
T
L
P
L
A
K
I
P
G
V
G
K
V
S
A
A
-
K
L
E
A
M
G
L
R
T
C
G
D
V
Q
K
C
D
L
V
M
L
L
K
R
F
G
-
K
F
-
G
R
I
-
L
W
E
R
S
Q
G
I
D
E
R
D
V
N
S
E
R
L
R
--
K
S
V
G
V
E
R
T
M
A
E
D
--
I
H
H
W
S
E
C
E
A
I
I
E
R
L
Y
P
E
L
E
R
R
L
A
K
V
K
P
----
D
--
L
L
I
A
R
Q
G
V
K
L
K
F
D
D
F
Q
Q
T
---
T
Q
E
H
V
W
----
P
R
L
N
K
A
D
L
I
A
T
A
R
K
T
W
D
E
---
R
R
-
G
G
R
G
V
R
L
V
G
L
H
V
T
L
L
---------------------------------------------------------------------
113
HHSearch
69.21
36%
-18
- C3 -
4Q45
5
DPO4_ECOLI
F:
[2-342]
----
S
R
K
I
I
H
V
D
M
D
C
F
F
A
A
V
E
M
R
D
N
P
A
L
R
D
I
P
I
A
I
G
--
G
--
S
R
-
E
R
R
G
V
I
S
T
A
N
Y
P
A
R
K
F
G
V
R
S
A
M
P
T
G
M
A
L
A
L
C
P
H
L
T
L
L
P
-------
G
R
F
D
A
Y
K
E
A
S
N
H
I
R
-
E
I
F
S
R
Y
T
S
R
I
E
P
L
S
L
D
E
A
Y
L
D
V
T
D
S
V
-
H
-----
C
-
H
G
S
----------------------------------------------------
A
T
L
I
A
Q
E
I
R
Q
T
I
F
N
E
L
Q
L
T
A
S
A
G
V
A
P
V
K
F
L
A
K
I
A
S
D
M
N
K
P
N
G
Q
F
V
I
T
P
A
E
V
P
A
F
L
Q
T
L
P
L
A
K
I
P
G
V
G
K
V
S
A
A
-
K
L
E
A
M
G
L
R
T
C
G
D
V
Q
A
C
D
L
V
M
L
L
K
R
F
G
-
K
F
-
G
R
I
-
L
W
E
R
S
Q
G
I
D
E
R
D
V
N
S
--
E
R
L
R
K
S
V
G
V
E
R
T
M
A
E
D
--
I
H
H
W
S
E
C
E
A
I
I
E
R
L
Y
P
E
L
E
R
R
L
A
--
K
V
----
K
PD
L
L
I
A
R
Q
G
V
K
L
K
F
D
D
F
Q
Q
T
---
T
Q
--
E
H
V
--
W
P
R
L
N
K
A
D
L
I
A
T
A
R
K
T
W
-
D
---
E
R
R
G
G
R
G
V
R
L
V
G
L
H
V
T
L
L
D
P
-------------------------------------------------------------------
4
PsiBlast_PDB
69.16
35%
-12
- C3 -
4Q44
7
DPO4_ECOLI
A:
[2-340]
----
S
R
K
I
I
H
V
D
M
D
C
F
F
A
A
V
E
M
R
D
N
P
A
L
R
D
I
P
I
A
I
G
--
G
--
S
-
R
E
R
R
G
V
I
S
T
A
N
Y
P
A
R
K
F
G
V
R
S
A
M
P
T
G
M
A
L
A
L
C
P
H
L
T
L
L
P
-------
G
R
F
D
A
Y
K
E
A
S
N
H
I
R
-
E
I
F
S
R
Y
T
S
R
I
E
P
L
S
L
D
E
A
Y
L
D
V
T
D
S
V
-
H
-----
C
H
G
-
S
----------------------------------------------------
A
T
L
I
A
Q
E
I
R
Q
T
I
F
N
E
L
Q
L
T
A
S
A
G
V
A
P
V
K
F
L
A
K
I
A
S
D
M
N
K
P
N
G
Q
F
V
I
T
P
A
E
V
P
A
F
L
Q
T
L
P
L
A
K
I
P
G
V
G
K
V
S
A
A
-
K
L
E
A
M
G
L
R
T
C
G
D
V
Q
A
C
D
L
V
M
L
L
K
R
F
G
-
K
F
-
G
R
I
-
L
W
E
R
S
Q
G
I
D
E
R
D
V
N
S
E
R
L
R
--
K
S
V
G
V
E
R
T
M
A
E
D
--
I
H
H
W
S
E
C
E
A
I
I
E
R
L
Y
P
E
L
E
R
R
L
A
K
V
K
P
----
D
--
L
L
I
A
R
Q
G
V
K
L
K
F
D
D
F
Q
Q
T
---
T
Q
E
H
V
W
----
P
R
L
N
K
A
D
L
I
A
T
A
R
K
T
W
D
E
---
R
R
-
G
G
R
G
V
R
L
V
G
L
H
V
T
L
L
---------------------------------------------------------------------
2
PsiBlast_PDB
69.06
35%
-12
- C3 -
4IRD
5
DPO4_ECOLI
F:
[2-340]
----
S
R
K
I
I
H
V
D
M
D
C
F
F
A
A
V
E
M
R
D
N
P
A
L
R
D
I
P
I
A
I
G
--
G
--
S
-
R
E
R
R
G
V
I
S
T
A
N
Y
P
A
R
K
F
G
V
R
S
A
M
P
T
G
M
A
L
A
L
C
P
H
L
T
L
L
P
-------
G
R
F
D
A
Y
K
E
A
S
N
H
I
R
-
E
I
F
S
R
Y
T
S
R
I
E
P
L
S
L
D
E
A
Y
L
D
V
T
D
S
V
-
H
-----
C
H
G
-
S
----------------------------------------------------
A
T
L
I
A
Q
E
I
R
Q
T
I
F
N
E
L
Q
L
T
A
S
A
G
V
A
P
V
K
F
L
A
K
I
A
S
D
M
N
K
P
N
G
Q
F
V
I
T
P
A
E
V
P
A
F
L
Q
T
L
P
L
A
K
I
P
G
V
G
K
V
S
A
A
-
K
L
E
A
M
G
L
R
T
C
G
D
V
Q
A
C
D
L
V
M
L
L
K
R
F
G
-
K
F
-
G
R
I
-
L
W
E
R
S
Q
G
I
D
E
R
D
V
N
S
E
R
L
R
--
K
S
V
G
V
E
R
T
M
A
E
D
--
I
H
H
W
S
E
C
E
A
I
I
E
R
L
Y
P
E
L
E
R
R
L
A
KV
K
P
----
D
--
L
L
I
A
R
Q
G
V
K
L
K
F
D
D
F
Q
Q
T
---
T
Q
E
H
V
W
----
P
R
L
N
K
A
D
L
I
A
T
A
R
K
T
W
D
E
---
R
R
-
G
G
R
G
V
R
L
V
G
L
H
V
T
L
L
---------------------------------------------------------------------
22
PsiBlast_CBE
68.94
35%
-17
- C3 -
4Q44
5
DPO4_ECOLI
F:
[2-340]
----
S
R
K
I
I
H
V
D
M
D
C
F
F
A
A
V
E
M
R
D
N
P
A
L
R
D
I
P
I
A
I
G
--
G
--
S
-
R
E
R
R
G
V
I
S
T
A
N
Y
P
A
R
K
F
G
V
R
S
A
M
P
T
G
M
A
L
A
L
C
P
H
L
T
L
L
P
-------
G
R
F
D
A
Y
K
E
A
S
N
H
I
R
-
E
I
F
S
R
Y
T
S
R
I
E
P
L
S
L
D
E
A
Y
L
D
V
T
D
S
V
-
H
-----
C
H
G
-
S
----------------------------------------------------
A
T
L
I
A
Q
E
I
R
Q
T
I
F
N
E
L
Q
L
T
A
S
A
G
V
A
P
V
K
F
L
A
K
I
A
S
D
M
N
K
P
N
G
Q
F
V
I
T
P
A
E
V
P
A
F
L
Q
T
L
P
L
A
K
I
P
G
V
G
K
V
S
A
A
-
K
L
E
A
M
G
L
R
T
C
G
D
V
Q
A
C
D
L
V
M
L
L
K
R
F
G
-
K
F
-
G
R
I
-
L
W
E
R
S
Q
G
I
D
E
R
D
V
N
S
E
R
L
R
--
K
S
V
G
V
E
R
T
M
A
E
D
--
I
H
H
W
S
E
C
E
A
I
I
E
R
L
Y
P
E
L
E
R
R
L
A
KV
K
P
----
D
--
L
L
I
A
R
Q
G
V
K
L
K
F
D
D
F
Q
Q
T
---
T
Q
E
H
V
W
----
P
R
L
N
K
A
D
L
I
A
T
A
R
K
T
W
D
E
---
R
R
-
G
G
R
G
V
R
L
V
G
L
H
V
T
L
L
---------------------------------------------------------------------
7
PsiBlast_PDB
68.85
35%
-13
- C3 -
4IR9
5
DPO4_ECOLI
F:
[2-340]
----
S
R
K
I
I
H
V
D
M
D
C
F
F
A
A
V
E
M
R
D
N
P
A
L
R
D
I
P
I
A
I
G
--
G
--
S
-
R
E
R
R
G
V
I
S
T
A
N
Y
P
A
R
K
F
G
V
R
S
A
M
P
T
G
M
A
L
K
L
C
P
H
L
T
L
L
P
-------
G
R
F
D
A
Y
K
E
A
S
N
H
I
R
-
E
I
F
S
R
Y
T
S
R
I
E
P
L
S
L
D
E
A
Y
L
D
V
T
D
S
V
-
H
-----
C
H
G
-
S
----------------------------------------------------
A
T
L
I
A
Q
E
I
R
Q
T
I
F
N
E
L
Q
L
T
A
S
A
G
V
A
P
V
K
F
L
A
K
I
A
S
D
M
N
K
P
N
G
Q
F
V
I
T
P
A
E
V
P
A
F
L
Q
T
L
P
L
A
K
I
P
G
V
G
K
V
S
A
A
-
K
L
E
A
M
G
L
R
T
C
G
D
V
Q
K
C
D
L
V
M
L
L
K
R
F
G
-
K
F
-
G
R
I
-
L
W
E
R
S
Q
G
I
D
E
R
D
V
N
S
E
R
L
R
--
K
S
V
G
V
E
R
T
M
A
E
D
--
I
H
H
W
S
E
C
E
A
I
I
E
R
L
Y
P
E
L
E
R
R
L
A
KV
K
P
----
D
--
L
L
I
A
R
Q
G
V
K
L
K
F
D
D
F
Q
Q
T
---
T
Q
E
H
V
W
----
P
R
L
N
K
A
D
L
I
A
T
A
R
K
T
W
D
E
---
R
R
-
G
G
R
G
V
R
L
V
G
L
H
V
T
L
L
---------------------------------------------------------------------
1
PsiBlast_PDB
68.65
35%
-7
- C3 -
4IRC
5
DPO4_ECOLI
F:
[2-340]
----
S
R
K
I
I
H
V
D
M
D
C
F
F
A
A
V
E
M
R
D
N
P
A
L
R
D
I
P
I
A
I
G
--
G
--
S
-
R
E
R
R
G
V
I
S
T
A
N
Y
P
A
R
K
F
G
V
R
S
A
M
P
T
G
M
A
L
A
L
C
P
H
L
T
L
L
P
-------
G
R
F
D
A
Y
K
E
A
S
N
H
I
R
-
E
I
F
S
R
Y
T
S
R
I
E
P
L
S
L
D
E
A
Y
L
D
V
T
D
S
V
-
H
-----
C
H
G
-
S
----------------------------------------------------
A
T
L
I
A
Q
E
I
R
Q
T
I
F
N
E
L
Q
L
T
A
S
A
G
V
A
P
V
K
F
L
A
K
I
A
S
D
M
N
K
P
N
G
Q
F
V
I
T
P
A
E
V
P
A
F
L
Q
T
L
P
L
A
K
I
P
G
V
G
K
V
S
A
A
-
K
L
E
A
M
G
L
R
T
C
G
D
V
Q
A
C
D
L
V
M
L
L
K
R
F
G
-
K
F
-
G
R
I
-
L
W
E
R
S
Q
G
I
D
E
R
D
V
N
S
E
R
L
R
--
K
S
V
G
V
E
R
T
M
A
E
D
--
I
H
H
W
S
E
C
E
A
I
I
E
R
L
Y
P
E
L
E
R
R
L
A
KV
K
P
----
D
--
L
L
I
A
R
Q
G
V
K
L
K
F
D
D
F
Q
Q
T
---
T
Q
E
H
V
W
----
P
R
L
N
K
A
D
L
I
A
T
A
R
K
T
W
D
E
---
R
R
-
G
G
R
G
V
R
L
V
G
L
H
V
T
L
L
---------------------------------------------------------------------
21
PsiBlast_CBE
68.63
35%
-12
- C3 -
4Q45
7
DPO4_ECOLI
A:
[2-340]
----
S
R
K
I
I
H
V
D
M
D
C
F
F
A
A
V
E
M
R
D
N
P
A
L
R
D
I
P
I
A
I
G
--
G
--
S
-
R
E
R
R
G
V
I
S
T
A
N
Y
P
A
R
K
F
G
V
R
S
A
M
P
T
G
M
A
L
A
L
C
P
H
L
T
L
L
P
-------
G
R
F
D
A
Y
K
E
A
S
N
H
I
R
-
E
I
F
S
R
Y
T
S
R
I
E
P
L
S
L
D
E
A
Y
L
D
V
T
D
S
V
-
H
-----
C
H
G
-
S
----------------------------------------------------
A
T
L
I
A
Q
E
I
R
Q
T
I
F
N
E
L
Q
L
T
A
S
A
G
V
A
P
V
K
F
L
A
K
I
A
S
D
M
N
K
P
N
G
Q
F
V
I
T
P
A
E
V
P
A
F
L
Q
T
L
P
L
A
K
I
P
G
V
G
K
V
S
A
A
-
K
L
E
A
M
G
L
R
T
C
G
D
V
Q
A
C
D
L
V
M
L
L
K
R
F
G
-
K
F
-
G
R
I
-
L
W
E
R
S
Q
G
I
D
E
R
D
V
N
S
E
R
L
R
--
K
S
V
G
V
E
R
T
M
A
E
D
--
I
H
H
W
S
E
C
E
A
I
I
E
R
L
Y
P
E
L
E
R
R
L
A
K
V
K
P
----
D
--
L
L
I
A
R
Q
G
V
K
L
K
F
D
D
F
Q
Q
T
---
T
Q
E
H
V
W
----
P
R
L
N
K
A
D
L
I
A
T
A
R
K
T
W
D
E
---
R
R
-
G
G
R
G
V
R
L
V
G
L
H
V
T
L
L
---------------------------------------------------------------------
28
PsiBlast_CBE
68.32
35%
-13
- C3 -
4IR1
7
DPO4_ECOLI
A:
[2-340]
----
S
R
K
I
I
H
V
D
M
D
C
F
F
A
A
V
E
M
R
D
N
P
A
L
R
D
I
P
I
A
I
G
--
G
--
S
-
R
E
R
R
G
V
I
S
T
A
N
Y
P
A
R
K
F
G
V
R
S
A
M
P
T
G
M
A
L
K
L
C
P
H
L
T
L
L
P
-------
G
R
F
D
A
Y
K
E
A
S
N
H
I
R
-
E
I
F
S
R
Y
T
S
R
I
E
P
L
S
L
D
E
A
Y
L
D
V
T
D
S
V
-
H
-----
C
H
G
-
S
----------------------------------------------------
A
T
L
I
A
Q
E
I
R
Q
T
I
F
N
E
L
Q
L
T
A
S
A
G
V
A
P
V
K
F
L
A
K
I
A
S
D
M
N
K
P
N
G
Q
F
V
I
T
P
A
E
V
P
A
F
L
Q
T
L
P
L
A
K
I
P
G
V
G
K
V
S
A
A
-
K
L
E
A
M
G
L
R
T
C
G
D
V
Q
K
C
D
L
V
M
L
L
K
R
F
G
-
K
F
-
G
R
I
-
L
W
E
R
S
Q
G
I
D
E
R
D
V
N
S
E
R
L
R
--
K
S
V
G
V
E
R
T
M
A
E
D
--
I
H
H
W
S
E
C
E
A
I
I
E
R
L
Y
P
E
L
E
R
R
L
A
K
V
K
P
----
D
--
L
L
I
A
R
Q
G
V
K
L
K
F
D
D
F
Q
Q
T
---
T
Q
E
H
V
W
----
P
R
L
N
K
A
D
L
I
A
T
A
R
K
T
W
D
E
---
R
R
-
G
G
R
G
V
R
L
V
G
L
H
V
T
L
L
---------------------------------------------------------------------
29
PsiBlast_CBE
68.02
34%
-12
- C3 -
4R8U
4
?
B:
[1-336]
-----
R
K
I
I
H
V
D
M
D
C
F
F
A
A
V
E
M
R
D
N
P
A
L
R
D
I
P
I
A
I
G
--
G
--
S
-
R
E
R
R
G
V
I
S
T
A
N
Y
P
A
R
K
F
G
V
R
S
A
M
P
T
G
M
A
L
K
L
C
P
H
L
T
L
L
P
-------
G
R
F
D
A
Y
K
E
A
S
N
H
I
R
-
E
I
F
S
R
Y
T
S
R
I
E
P
L
S
L
D
E
A
Y
L
D
V
T
D
S
V
-
H
-----
C
H
G
-
S
----------------------------------------------------
A
T
L
I
A
Q
E
I
R
Q
T
I
F
N
E
L
Q
L
T
A
S
A
G
V
A
P
V
K
F
L
A
K
I
A
S
D
M
N
K
P
N
G
Q
F
V
I
T
P
A
E
V
P
A
F
L
Q
T
L
P
L
A
K
I
P
G
V
G
K
V
S
A
A
-
K
L
E
A
M
G
L
R
T
C
G
D
V
Q
K
C
D
L
V
M
L
L
K
R
F
G
-
K
F
-
G
R
I
-
L
W
E
R
S
Q
G
I
D
E
R
D
V
N
S
E
R
L
R
--
K
S
V
G
V
E
R
T
M
A
E
D
--
I
H
H
W
S
E
C
E
A
I
I
E
R
L
Y
P
E
L
E
R
R
L
A
K
V
K
P
----
D
--
L
L
I
A
R
Q
G
V
K
L
K
F
D
D
F
Q
Q
T
---
T
Q
E
H
V
W
----
P
R
L
N
K
A
D
L
I
A
T
A
R
K
T
W
D
E
---
R
R
-
G
G
R
G
V
R
L
V
G
L
H
V
T
-----------------------------------------------------------------------
27
PsiBlast_CBE
68.02
35%
-9
- C3 -
4IR9
7
DPO4_ECOLI
A:
[2-340]
----
S
R
K
I
I
H
V
D
M
D
C
F
F
A
A
V
E
M
R
D
N
P
A
L
R
D
I
P
I
A
I
G
--
G
--
S
-
R
E
R
R
G
V
I
S
T
A
N
Y
P
A
R
K
F
G
V
R
S
A
M
P
T
G
M
A
L
K
L
C
P
H
L
T
L
L
P
-------
G
R
F
D
A
Y
K
E
A
S
N
H
I
R
-
E
I
F
S
R
Y
T
S
R
I
E
P
L
S
L
D
E
A
Y
L
D
V
T
D
S
V
-
H
-----
C
H
G
-
S
----------------------------------------------------
A
T
L
I
A
Q
E
I
R
Q
T
I
F
N
E
L
Q
L
T
A
S
A
G
V
A
P
V
K
F
L
A
K
I
A
S
D
M
N
K
P
N
G
Q
F
V
I
T
P
A
E
V
P
A
F
L
Q
T
L
P
L
A
K
I
P
G
V
G
K
V
S
A
A
-
K
L
E
A
M
G
L
R
T
C
G
D
V
Q
K
C
D
L
V
M
L
L
K
R
F
G
-
K
F
-
G
R
I
-
L
W
E
R
S
Q
G
I
D
E
R
D
V
N
S
E
R
L
R
--
K
S
V
G
V
E
R
T
M
A
E
D
--
I
H
H
W
S
E
C
E
A
I
I
E
R
L
Y
P
E
L
E
R
R
L
A
K
V
K
P
----
D
--
L
L
I
A
R
Q
G
V
K
L
K
F
D
D
F
Q
Q
T
---
T
Q
E
H
V
W
----
P
R
L
N
K
A
D
L
I
A
T
A
R
K
T
W
D
E
---
R
R
-
G
G
R
G
V
R
L
V
G
L
H
V
T
L
L
---------------------------------------------------------------------
24
PsiBlast_CBE
68.00
35%
-9
- C3 -
4IRD
7
DPO4_ECOLI
A:
[2-340]
----
S
R
K
I
I
H
V
D
M
D
C
F
F
A
A
V
E
M
R
D
N
P
A
L
R
D
I
P
I
A
I
G
--
G
--
S
-
R
E
R
R
G
V
I
S
T
A
N
Y
P
A
R
K
F
G
V
R
S
A
M
P
T
G
M
A
L
A
L
C
P
H
L
T
L
L
P
-------
G
R
F
D
A
Y
K
E
A
S
N
H
I
R
-
E
I
F
S
R
Y
T
S
R
I
E
P
L
S
L
D
E
A
Y
L
D
V
T
D
S
V
-
H
-----
C
H
G
-
S
----------------------------------------------------
A
T
L
I
A
Q
E
I
R
Q
T
I
F
N
E
L
Q
L
T
A
S
A
G
V
A
P
V
K
F
L
A
K
I
A
S
D
M
N
K
P
N
G
Q
F
V
I
T
P
A
E
V
P
A
F
L
Q
T
L
P
L
A
K
I
P
G
V
G
K
V
S
A
A
-
K
L
E
A
M
G
L
R
T
C
G
D
V
Q
A
C
D
L
V
M
L
L
K
R
F
G
-
K
F
-
G
R
I
-
L
W
E
R
S
Q
G
I
D
E
R
D
V
N
S
E
R
L
R
--
K
S
V
G
V
E
R
T
M
A
E
D
--
I
H
H
W
S
E
C
E
A
I
I
E
R
L
Y
P
E
L
E
R
R
L
A
K
V
K
P
----
D
--
L
L
I
A
R
Q
G
V
K
L
K
F
D
D
F
Q
Q
T
---
T
Q
E
H
V
W
----
P
R
L
N
K
A
D
L
I
A
T
A
R
K
T
W
D
E
---
R
R
-
G
G
R
G
V
R
L
V
G
L
H
V
T
L
L
---------------------------------------------------------------------
8
PsiBlast_PDB
67.96
35%
-12
- C3 -
4Q43
7
DPO4_ECOLI
A:
[2-340]
----
S
R
K
I
I
H
V
D
M
D
C
F
F
A
A
V
E
M
R
D
N
P
A
L
R
D
I
P
I
A
I
G
--
G
--
S
-
R
E
R
R
G
V
I
S
T
A
N
Y
P
A
R
K
F
G
V
R
S
A
M
P
T
G
M
A
L
K
L
C
P
H
L
T
L
L
P
-------
G
R
F
D
A
Y
K
E
A
S
N
H
I
R
-
E
I
F
S
R
Y
T
S
R
I
E
P
L
S
L
D
E
A
Y
L
D
V
T
D
S
V
-
H
-----
C
H
G
-
S
----------------------------------------------------
A
T
L
I
A
Q
E
I
R
Q
T
I
F
N
E
L
Q
L
T
A
S
A
G
V
A
P
V
K
F
L
A
K
I
A
S
D
M
N
K
P
N
G
Q
F
V
I
T
P
A
E
V
P
A
F
L
Q
T
L
P
L
A
K
I
P
G
V
G
K
V
S
A
A
-
K
L
E
A
M
G
L
R
T
C
G
D
V
Q
K
C
D
L
V
M
L
L
K
R
F
G
-
K
F
-
G
R
I
-
L
W
E
R
S
Q
G
I
D
E
R
D
V
N
S
E
R
L
R
--
K
S
V
G
V
E
R
T
M
A
E
D
--
I
H
H
W
S
E
C
E
A
I
I
E
R
L
Y
P
E
L
E
R
R
L
A
K
V
K
P
----
D
--
L
L
I
A
R
Q
G
V
K
L
K
F
D
D
F
Q
Q
T
---
T
Q
E
H
V
W
----
P
R
L
N
K
A
D
L
I
A
T
A
R
K
T
W
D
E
---
R
R
-
G
G
R
G
V
R
L
V
G
L
H
V
T
L
L
---------------------------------------------------------------------
25
PsiBlast_CBE
67.56
35%
-9
- C3 -
4IRC
7
DPO4_ECOLI
A:
[2-340]
----
S
R
K
I
I
H
V
D
M
D
C
F
F
A
A
V
E
M
R
D
N
P
A
L
R
D
I
P
I
A
I
G
--
G
--
S
-
R
E
R
R
G
V
I
S
T
A
N
Y
P
A
R
K
F
G
V
R
S
A
M
P
T
G
M
A
L
A
L
C
P
H
L
T
L
L
P
-------
G
R
F
D
A
Y
K
E
A
S
N
H
I
R
-
E
I
F
S
R
Y
T
S
R
I
E
P
L
S
L
D
E
A
Y
L
D
V
T
D
S
V
-
H
-----
C
H
G
-
S
----------------------------------------------------
A
T
L
I
A
Q
E
I
R
Q
T
I
F
N
E
L
Q
L
T
A
S
A
G
V
A
P
V
K
F
L
A
K
I
A
S
D
M
N
K
P
N
G
Q
F
V
I
T
P
A
E
V
P
A
F
L
Q
T
L
P
L
A
K
I
P
G
V
G
K
V
S
A
A
-
K
L
E
A
M
G
L
R
T
C
G
D
V
Q
A
C
D
L
V
M
L
L
K
R
F
G
-
K
F
-
G
R
I
-
L
W
E
R
S
Q
G
I
D
E
R
D
V
N
S
E
R
L
R
--
K
S
V
G
V
E
R
T
M
A
E
D
--
I
H
H
W
S
E
C
E
A
I
I
E
R
L
Y
P
E
L
E
R
R
L
A
K
V
K
P
----
D
--
L
L
I
A
R
Q
G
V
K
L
K
F
D
D
F
Q
Q
T
---
T
Q
E
H
V
W
----
P
R
L
N
K
A
D
L
I
A
T
A
R
K
T
W
D
E
---
R
R
-
G
G
R
G
V
R
L
V
G
L
H
V
T
L
L
---------------------------------------------------------------------
121
HHSearch
66.82
28%
-19
- C3 -
4ECQ
7
POLH_HUMAN
A:
[7-434]
--
G
Q
D
R
V
V
A
L
V
D
M
D
C
F
F
V
Q
V
E
Q
R
Q
N
P
H
L
R
N
K
P
C
A
V
V
--
Q
--
Y
K
S
W
K
G
G
G
I
I
A
V
S
Y
E
A
R
A
F
G
V
T
R
S
M
W
A
D
D
A
K
K
L
C
P
D
L
L
L
A
Q
V
R
ESRGK
A
N
L
T
K
Y
R
E
A
S
V
E
V
M
-
E
I
M
S
R
F
A
-
V
I
E
R
A
S
I
D
E
A
Y
V
D
L
T
S
A
V
-
Q
E
R
L
Q
K
L
-
Q
G
Q
P
I
S
ADLLPSTYIEGLPQGPTVQ
K
E
G
M
R
K
Q
G
L
F
Q
W
L
D
S
LQIDNLTS
P
D
L
Q
L
T
V
G
A
V
I
V
E
E
M
R
A
A
I
E
R
E
T
G
F
Q
C
S
A
G
I
S
H
N
K
V
L
A
K
L
A
C
G
L
N
K
P
N
R
Q
T
L
V
S
H
G
S
V
P
Q
L
F
S
Q
M
P
I
R
K
I
R
S
L
G
G
K
L
G
A
S
V
I
E
I
L
G
I
E
Y
M
G
E
L
T
Q
F
T
E
S
Q
L
Q
S
H
F
G
-
E
K
N
G
S
W
-
L
Y
A
M
C
R
G
I
E
H
D
P
V
K
P
--
R
Q
L
P
K
T
I
G
C
S
K
N
F
P
G
K
TA
L
A
T
R
E
Q
V
Q
W
W
L
L
Q
L
A
Q
E
L
E
E
R
L
T
--
K
D
R
N
D
N
D
--
R
V
A
T
Q
L
V
V
S
I
R
V
Q
G
D
K
R
L
SS
L
R
R
C
C
A
L
T
RY
D
A
H
K
M
S
H
D
A
F
T
V
I
K
N
C
N
-
T
SGI
Q
T
E
W
S
P
P
L
T
M
L
F
L
C
A
T
K
F
S
A
-------------------------------------------------------------------
56
PsiBlast_CBE
56.91
33%
5
- C3 -
2V4R
6
DPO4_SULSO
A:
[8-267]
------
I
V
L
F
V
D
F
D
Y
F
Y
A
Q
V
E
E
V
L
N
P
S
L
K
G
K
P
V
V
V
C
V
F
S
--
G
R
F
E
D
S
G
A
V
A
T
A
N
Y
E
A
R
K
F
G
V
K
A
G
I
P
I
V
E
A
K
K
I
L
P
N
A
V
Y
L
P
-------
M
R
K
E
V
Y
Q
Q
V
S
S
R
I
M
-
N
L
L
R
E
Y
S
E
K
I
E
I
A
S
I
D
E
A
Y
L
D
I
S
D
K
V
-
R
-----
D
-
Y
-
R
E
---------------------------------------------------
A
Y
N
L
G
L
E
I
K
N
K
I
L
E
K
E
K
I
T
V
T
V
G
I
S
K
N
K
V
F
A
K
I
A
A
D
M
A
K
P
N
G
I
K
V
I
D
D
E
E
V
K
R
L
I
R
E
L
D
I
A
D
V
P
G
I
G
N
I
T
A
E
-
K
L
K
K
L
G
I
N
K
L
V
D
T
L
S
I
E
F
D
K
L
K
G
M
I
G
E
A
K
-
A
K
Y
-
L
I
S
L
A
R
D
E
Y
N
E
P
I
---
R
T
R
V
R
K
S
I
G
R
I
V
T
M
K
R
N
--
S
R
N
L
E
E
I
----------------------------------------------------------------------------------------------------------------------------------------------------------------------
10
PsiBlast_PDB
56.49
34%
-2
- C3 -
2W9B
4
DPO4_SULSO
A:
[8-267]
------
I
V
L
F
V
D
F
D
Y
F
Y
A
Q
V
E
E
V
L
N
P
S
L
K
G
K
P
V
V
V
C
V
F
S
--
G
R
F
E
D
S
G
A
V
A
T
A
N
Y
E
A
R
K
F
G
V
K
A
G
I
P
I
V
E
A
K
K
I
L
P
N
A
V
Y
L
P
-------
M
R
K
E
V
Y
Q
Q
V
S
S
R
I
M
-
N
L
L
R
E
Y
S
E
K
I
E
I
A
S
I
D
E
A
Y
L
D
I
S
D
K
V
-
R
-----
D
-
Y
-
R
E
---------------------------------------------------
A
Y
N
L
G
L
E
I
K
N
K
I
L
E
K
E
K
I
T
V
T
V
G
I
S
K
N
K
V
F
A
K
I
A
A
D
M
A
K
P
N
G
I
K
V
I
D
D
E
E
V
K
R
L
I
R
E
L
D
I
A
D
V
P
G
I
G
N
I
T
A
E
-
K
L
K
K
L
G
I
N
K
L
V
D
T
L
S
I
E
F
D
K
L
K
G
M
I
G
-
E
A
-
K
A
R
Y
L
I
S
L
A
R
D
E
Y
N
E
P
I
---
R
T
R
V
R
K
S
I
G
R
I
V
T
M
K
R
N
--
S
R
N
L
E
E
I
----------------------------------------------------------------------------------------------------------------------------------------------------------------------
60
PsiBlast_CBE
56.30
33%
9
- C3 -
2R8I
6
DPO4_SULSO
A:
[2-261]
------
I
V
L
F
V
D
F
D
Y
F
Y
A
Q
V
E
E
V
L
N
P
S
L
K
G
K
P
V
V
V
C
V
F
S
--
G
R
F
E
D
S
G
A
V
A
T
A
N
Y
E
A
R
K
F
G
V
K
A
G
I
P
I
V
E
A
K
K
I
L
P
N
A
V
Y
L
P
-------
M
R
K
E
V
Y
Q
Q
V
S
S
R
I
M
-
N
L
L
R
E
Y
S
E
K
I
E
I
A
S
I
D
E
A
Y
L
D
I
S
D
K
V
-
R
-----
D
-
Y
-
R
E
---------------------------------------------------
A
Y
N
L
G
L
E
I
K
N
K
I
L
E
K
E
K
I
T
V
T
V
G
I
S
K
N
K
V
F
A
K
I
A
A
D
M
A
K
P
N
G
I
K
V
I
D
D
E
E
V
K
R
L
I
R
E
L
D
I
A
D
V
P
G
I
G
N
I
T
A
E
-
K
L
K
K
L
G
I
N
K
L
V
D
T
L
S
I
E
F
D
K
L
K
G
M
I
G
E
A
K
-
A
K
Y
-
L
I
S
L
A
R
D
E
Y
N
E
P
I
---
R
T
R
V
R
K
S
I
G
R
I
V
T
M
K
R
N
--
S
R
N
L
E
E
I
----------------------------------------------------------------------------------------------------------------------------------------------------------------------
59
PsiBlast_CBE
56.24
33%
8
- C3 -
2RDJ
6
DPO4_SULSO
A:
[2-261]
------
I
V
L
F
V
D
F
D
Y
F
Y
A
Q
V
E
E
V
L
N
P
S
L
K
G
K
P
V
V
V
C
VF
S
--
G
R
F
E
D
S
G
A
V
A
T
A
N
Y
E
A
R
K
F
G
V
K
A
G
I
P
I
V
E
A
K
K
I
L
P
N
A
V
Y
L
P
-------
M
R
K
E
V
Y
Q
Q
V
S
S
R
I
M
-
N
L
L
R
E
Y
S
E
K
I
E
I
A
S
I
D
E
A
Y
L
D
I
S
D
K
V
-
R
-----
D
-
Y
-
R
E
---------------------------------------------------
A
Y
N
L
G
L
E
I
K
N
K
I
L
E
K
E
K
I
T
V
T
V
G
I
S
K
N
K
V
F
A
K
I
A
A
D
M
A
K
P
N
G
I
K
V
I
D
D
E
E
V
K
R
L
I
R
E
L
D
I
A
D
V
P
G
I
G
N
I
T
A
E
-
K
L
K
K
L
G
I
N
K
L
V
D
T
L
S
I
E
F
D
K
L
K
G
M
I
G
E
A
K
-
A
K
Y
-
L
I
S
L
A
R
D
E
Y
N
E
P
I
---
R
T
R
V
R
K
S
I
G
R
I
V
T
M
K
R
N
--
S
R
N
L
E
E
I
----------------------------------------------------------------------------------------------------------------------------------------------------------------------
11
PsiBlast_PDB
56.21
34%
0
- C3 -
2W9C
6
DPO4_SULSO
A:
[8-267]
------
I
V
L
F
V
D
F
D
Y
F
Y
A
Q
V
E
E
V
L
N
P
S
L
K
G
K
P
V
V
V
C
V
F
S
--
G
R
F
E
D
S
G
A
V
A
T
A
N
Y
E
A
R
K
F
G
V
K
A
G
I
P
I
V
E
A
K
K
I
L
P
N
A
V
Y
L
P
-------
M
R
K
E
V
Y
Q
Q
V
S
S
R
I
M
-
N
L
L
R
E
Y
S
E
K
I
E
I
A
S
I
D
E
A
Y
L
D
I
S
D
K
V
-
R
-----
D
-
Y
-
R
E
---------------------------------------------------
A
Y
N
L
G
L
E
I
K
N
K
I
L
E
K
E
K
I
T
V
T
V
G
I
S
K
N
K
V
F
A
K
I
A
A
D
M
A
K
P
N
G
I
K
V
I
D
D
E
E
V
K
R
L
I
R
E
L
D
I
A
D
V
P
G
I
G
N
I
T
A
E
-
K
L
K
K
L
G
I
N
K
L
V
D
T
L
S
I
E
F
D
K
L
K
G
M
I
G
-
E
A
-
K
A
R
Y
L
I
S
L
A
R
D
E
Y
N
E
P
I
---
R
T
R
V
R
K
S
I
G
R
I
V
T
M
K
R
N
--
S
R
N
L
E
E
I
----------------------------------------------------------------------------------------------------------------------------------------------------------------------
88
PsiBlast_CBE
55.95
33%
7
- C3 -
1S97
4
DPO4_SULSO
B:
[2-261]
------
I
V
L
F
V
D
F
D
Y
F
Y
A
Q
V
E
E
V
L
N
P
S
L
K
G
K
P
V
V
V
C
VF
S
--
G
R
F
E
D
S
G
A
V
A
T
A
N
Y
E
A
R
K
F
G
V
K
A
G
I
P
I
V
E
A
K
K
I
L
P
N
A
V
Y
L
P
-------
M
R
K
E
V
Y
Q
Q
V
S
S
R
I
M
-
N
L
L
R
E
Y
S
E
K
I
E
I
A
S
I
D
E
A
Y
L
D
I
S
D
K
V
-
R
-----
D
-
Y
-
R
E---------------------------------------------------
A
Y
N
L
G
L
E
I
K
N
K
I
L
E
K
E
K
I
T
V
T
V
G
I
S
K
N
K
V
F
A
K
I
A
A
D
M
A
K
P
N
G
I
K
V
I
D
D
E
E
V
K
R
L
I
R
E
L
D
I
A
D
V
P
G
I
G
N
I
T
A
E
-
K
L
K
K
L
G
I
N
K
L
V
D
T
L
S
I
E
F
D
K
L
K
G
M
I
G
E
A
K
-
A
K
Y
-
L
I
S
L
A
R
D
E
Y
N
E
P
I
---
R
T
R
V
R
K
S
I
G
R
I
V
T
M
K
R
N
--
S
R
N
L
E
E
I
----------------------------------------------------------------------------------------------------------------------------------------------------------------------
85
PsiBlast_CBE
55.93
33%
7
- C3 -
1S9F
6
DPO4_SULSO
A:
[2-261]
------
I
V
L
F
V
D
F
D
Y
F
Y
A
Q
V
E
E
V
L
N
P
S
L
K
G
K
P
V
V
V
C
VF
S
--
G
R
F
E
D
S
G
A
V
A
T
A
N
Y
E
A
R
K
F
G
V
K
A
G
I
P
I
V
E
A
K
K
I
L
P
N
A
V
Y
L
P
-------
M
R
K
E
V
Y
Q
Q
V
S
S
R
I
M
-
N
L
L
R
E
Y
S
E
K
I
E
I
A
S
I
D
E
A
Y
L
D
I
S
D
K
V
-
R
-----
D
-
Y
-
R
E
---------------------------------------------------
A
Y
N
L
G
L
E
I
K
N
K
I
L
E
K
E
K
I
T
V
T
V
G
I
S
K
N
K
V
F
A
K
I
A
A
D
M
A
K
P
N
G
I
K
V
I
D
D
E
E
V
K
R
L
I
R
E
L
D
I
A
D
V
P
G
I
G
N
I
T
A
E
-
K
L
K
K
L
G
I
N
K
L
V
D
T
L
S
I
E
F
D
K
L
K
G
M
I
G
E
A
K
-
A
K
Y
-
L
I
S
L
A
R
D
E
Y
N
E
P
I
---
R
T
R
V
R
K
S
I
G
R
I
V
T
M
K
R
N
--
S
R
N
L
E
E
I
----------------------------------------------------------------------------------------------------------------------------------------------------------------------
43
PsiBlast_CBE
55.90
33%
8
- C3 -
2XCP
6
DPO4_SULSO
A:
[8-267]
------
I
V
L
F
V
D
F
D
Y
F
Y
A
Q
V
E
E
V
L
N
P
S
L
K
G
K
P
V
V
V
C
V
F
S
--
G
R
F
E
D
S
G
A
V
A
T
A
N
Y
E
A
R
K
F
G
V
K
A
G
I
P
I
V
E
A
K
K
I
L
P
N
A
V
Y
L
P
-------
M
R
K
E
V
Y
Q
Q
V
S
S
R
I
M
-
N
L
L
R
E
Y
S
E
K
I
E
I
A
S
I
D
E
A
Y
L
D
I
S
D
K
V
-
R
-----
D
-
Y
-
R
E
---------------------------------------------------
A
Y
N
L
G
L
E
I
K
N
K
I
L
E
K
E
K
I
T
V
T
V
G
I
S
K
N
K
V
F
A
K
I
A
A
D
M
A
K
P
N
G
I
K
V
I
D
D
E
E
V
K
R
L
I
R
E
L
D
I
A
D
V
P
G
I
G
N
I
T
A
E
-
K
L
K
K
L
G
I
N
K
L
V
D
T
L
S
I
E
F
D
K
L
K
G
M
I
G
E
A
K
-
A
K
Y
-
L
I
S
L
A
R
D
E
Y
N
E
P
I
---
R
T
R
V
R
K
S
I
G
R
I
V
T
M
K
R
N
--
S
R
N
L
E
E
I
----------------------------------------------------------------------------------------------------------------------------------------------------------------------
52
PsiBlast_CBE
55.87
33%
1
- C3 -
2VA2
5
DPO4_SULSO
B:
[8-267]
------
I
V
L
F
V
D
F
D
Y
F
Y
A
Q
V
E
E
V
L
N
P
S
L
K
G
K
P
V
V
V
C
V
F
S
--
G
R
F
E
D
S
G
A
V
A
T
A
N
Y
E
A
R
K
F
G
V
K
A
G
I
P
I
V
E
A
K
K
I
L
P
N
A
V
Y
L
P
-------
M
R
K
E
V
Y
Q
Q
V
S
S
R
I
M
-
N
L
L
R
E
Y
S
E
K
I
E
I
A
S
I
D
E
A
Y
L
D
I
S
D
K
V
-
R
-----
D
-
Y
-
R
E
---------------------------------------------------
A
Y
N
L
G
L
E
I
K
N
K
I
L
E
K
E
K
I
T
V
T
V
G
I
S
K
N
K
V
F
A
K
I
A
A
D
M
A
K
P
N
G
I
K
V
I
D
D
E
E
V
K
R
L
I
R
E
L
D
I
A
D
V
P
G
I
G
N
I
T
A
E
-
K
L
K
K
L
G
I
N
K
L
V
D
T
L
S
I
E
F
D
K
L
K
G
M
I
G
E
A
K
-
A
K
Y
-
L
I
S
L
A
R
D
E
Y
N
E
P
I
---
R
T
R
V
R
K
S
I
G
R
I
V
T
M
K
R
N
--
S
R
N
L
E
E
I
----------------------------------------------------------------------------------------------------------------------------------------------------------------------
86
PsiBlast_CBE
55.84
33%
4
- C3 -
1S97
4
DPO4_SULSO
D:
[2-261]
------
I
V
L
F
V
D
F
D
Y
F
Y
A
Q
V
E
E
V
L
N
P
S
L
K
G
K
P
V
V
V
C
VF
S
--
G
R
F
E
D
S
G
A
V
A
T
A
N
Y
E
A
R
K
F
G
V
K
A
G
I
P
I
V
E
A
K
K
I
L
P
N
A
V
Y
L
P
-------
M
R
K
E
V
Y
Q
Q
V
S
S
R
I
M
-
N
L
L
R
E
Y
S
E
K
I
E
I
A
S
I
D
E
A
Y
L
D
I
S
D
K
V
-
R
-----
D
-
Y
-
R
E---------------------------------------------------
A
Y
N
L
G
L
E
I
K
N
K
I
L
E
K
E
K
I
T
V
T
V
G
I
S
K
N
K
V
F
A
K
I
A
A
D
M
A
K
P
N
G
I
K
V
I
D
D
E
E
V
K
R
L
I
R
E
L
D
I
A
D
V
P
G
I
G
N
I
T
A
E
-
K
L
K
K
L
G
I
N
K
L
V
D
T
L
S
I
E
F
D
K
L
K
G
M
I
G
E
A
K
-
A
K
Y
-
L
I
S
L
A
R
D
E
Y
N
E
P
I
---
R
T
R
V
R
K
S
I
G
R
I
V
T
M
K
R
N
--
S
R
N
L
E
E
I
----------------------------------------------------------------------------------------------------------------------------------------------------------------------
92
PsiBlast_CBE
55.80
33%
9
- C3 -
1S0O
6
DPO4_SULSO
A:
[2-261]
------
I
V
L
F
V
D
F
D
Y
F
Y
A
Q
V
E
E
V
L
N
P
S
L
K
G
K
P
V
V
V
C
VF
S
--
G
R
F
E
D
S
G
A
V
A
T
A
N
Y
E
A
R
K
F
G
V
K
A
G
I
P
I
V
E
A
K
K
I
L
P
N
A
V
Y
L
P
-------
M
R
K
E
V
Y
Q
Q
V
S
S
R
I
M
-
N
L
L
R
E
Y
S
E
K
I
E
I
A
S
I
D
E
A
Y
L
D
I
S
D
K
V
-
R
-----
D
-
Y
-
R
E
---------------------------------------------------
A
Y
N
L
G
L
E
I
K
N
K
I
L
E
K
E
K
I
T
V
T
V
G
I
S
K
N
K
V
F
A
K
I
A
A
D
M
A
K
P
N
G
I
K
V
I
D
D
E
E
V
K
R
L
I
R
E
L
D
I
A
D
V
P
G
I
G
N
I
T
A
E
-
K
L
K
K
L
G
I
N
K
L
V
D
T
L
S
I
E
F
D
K
L
K
G
M
I
G
E
A
K
-
A
K
Y
-
L
I
S
L
A
R
D
E
Y
N
E
P
I
---
R
T
R
V
R
K
S
I
G
R
I
V
T
M
K
R
N
--
S
R
N
L
E
E
I
----------------------------------------------------------------------------------------------------------------------------------------------------------------------
32
PsiBlast_CBE
55.80
33%
3
- C3 -
4TQS
6
DPO4_SULSO
A:
[8-267]
------
I
V
L
F
V
D
F
D
Y
F
Y
A
Q
V
E
E
V
L
N
P
S
L
K
G
K
P
V
V
V
C
V
F
S
--
G
R
F
E
D
S
G
A
V
A
T
A
N
Y
E
A
R
K
F
G
V
K
A
G
I
P
I
V
E
A
K
K
I
L
P
N
A
V
Y
L
P
-------
M
R
K
E
V
Y
Q
Q
V
S
S
R
I
M
-
N
L
L
R
E
Y
S
E
K
I
E
I
A
S
I
D
E
A
Y
L
D
I
S
D
K
V
-
R
-----
D
-
Y
-
R
E
---------------------------------------------------
A
Y
N
L
G
L
E
I
K
N
K
I
L
E
K
E
K
I
T
V
T
V
G
I
S
K
N
K
V
F
A
K
I
A
A
D
M
A
K
P
N
G
I
K
V
I
D
D
E
E
V
K
R
L
I
R
E
L
D
I
A
D
V
P
G
I
G
N
I
T
A
E
-
K
L
K
K
L
G
I
N
K
L
V
D
T
L
S
I
E
F
D
K
L
K
G
M
I
G
E
A
K
-
A
K
Y
-
L
I
S
L
A
R
D
E
Y
N
E
P
I
---
R
T
R
V
R
K
S
I
G
R
I
V
T
M
K
R
N
--
S
R
N
L
E
E
I
----------------------------------------------------------------------------------------------------------------------------------------------------------------------
36
PsiBlast_CBE
55.74
33%
8
- C3 -
4GC7
7
DPO4_SULSO
A:
[9-268]
------
I
V
L
F
V
D
F
D
Y
F
Y
A
Q
V
E
E
V
L
N
P
S
L
K
G
K
P
V
V
V
C
V
F
S
--
G
R
F
E
D
S
G
A
V
A
T
A
N
Y
E
A
R
K
F
G
V
K
A
G
I
P
I
V
E
A
K
K
I
L
P
N
A
V
Y
L
P
-------
M
R
K
E
V
Y
Q
Q
V
S
S
R
I
M
-
N
L
L
R
E
Y
S
E
K
I
E
I
A
S
I
D
E
A
Y
L
D
I
S
D
K
V
-
R
-----
D
-
Y
-
R
E
---------------------------------------------------
A
Y
N
L
G
L
E
I
K
N
K
I
L
E
K
E
K
I
T
V
T
V
G
I
S
K
N
K
V
F
A
K
I
A
A
D
M
A
K
P
N
G
I
K
V
I
D
D
E
E
V
K
R
L
I
R
E
L
D
I
A
D
V
P
G
I
G
N
I
T
A
E
-
K
L
K
K
L
G
I
N
K
L
V
D
T
L
S
I
E
F
D
K
L
K
G
M
I
G
E
A
K
-
A
K
Y
-
L
I
S
L
A
R
D
E
Y
N
E
P
I
---
R
T
R
V
R
K
S
I
G
R
I
V
T
M
K
R
N
--
S
R
N
L
E
E
I
----------------------------------------------------------------------------------------------------------------------------------------------------------------------
31
PsiBlast_CBE
55.70
33%
6
- C3 -
4TQS
6
?
B:
[8-267]
------
I
V
L
F
V
D
F
D
Y
F
Y
A
Q
V
E
E
V
L
N
P
S
L
K
G
K
P
V
V
V
C
V
F
S
--
G
R
F
E
D
S
G
A
V
A
T
A
N
Y
E
A
R
K
F
G
V
K
A
G
I
P
I
V
E
A
K
K
I
L
P
N
A
V
Y
L
P
-------
M
R
K
E
V
Y
Q
Q
V
S
S
R
I
M
-
N
L
L
R
E
Y
S
E
K
I
E
I
A
S
I
D
E
A
Y
L
D
I
S
D
K
V
-
R
-----
D
-
Y
-
R
E
---------------------------------------------------
A
Y
N
L
G
L
E
I
K
N
K
I
L
E
K
E
K
I
T
V
T
V
G
I
S
K
N
K
V
F
A
K
I
A
A
D
M
A
K
P
N
G
I
K
V
I
D
D
E
E
V
K
R
L
I
R
E
L
D
I
A
D
V
P
G
I
G
N
I
T
A
E
-
K
L
K
K
L
G
I
N
K
L
V
D
T
L
S
I
E
F
D
K
L
K
G
M
I
G
E
A
K
-
A
K
Y
-
L
I
S
L
A
R
D
E
Y
N
E
P
I
---
R
T
R
V
R
K
S
I
G
R
I
V
T
M
K
R
N
--
S
R
N
L
E
E
I
----------------------------------------------------------------------------------------------------------------------------------------------------------------------
65
PsiBlast_CBE
55.63
33%
7
- C3 -
2JEG
6
DPO4_SULSO
A:
[8-267]
------
I
V
L
F
V
D
F
D
Y
F
Y
A
Q
V
E
E
V
L
N
P
S
L
K
G
K
P
V
V
V
C
V
F
S
--
G
R
F
E
D
S
G
A
V
A
T
A
N
Y
E
A
R
K
F
G
V
K
A
G
I
P
I
V
E
A
K
K
I
L
P
N
A
V
Y
L
P
-------
M
R
K
E
V
Y
Q
Q
V
S
S
R
I
M
-
N
L
L
R
E
Y
S
E
K
I
E
I
A
S
I
D
E
A
Y
L
D
I
S
D
K
V
-
R
-----
D
-
Y
-
R
E
---------------------------------------------------
A
Y
N
L
G
L
E
I
K
N
K
I
L
E
K
E
K
I
T
V
T
V
G
I
S
K
N
K
V
F
A
K
I
A
A
D
M
A
K
P
N
G
I
K
V
I
D
D
E
E
V
K
R
L
I
R
E
L
D
I
A
D
V
P
G
I
G
N
I
T
A
E
-
K
L
K
K
L
G
I
N
K
L
V
D
T
L
S
I
E
F
D
K
L
K
G
M
I
G
E
A
K
-
A
K
Y
-
L
I
S
L
A
R
D
E
Y
N
E
P
I
---
R
T
R
V
R
K
S
I
G
R
I
V
T
M
K
R
N
--
S
R
N
L
E
E
I
----------------------------------------------------------------------------------------------------------------------------------------------------------------------
37
PsiBlast_CBE
55.55
33%
5
- C3 -
4GC6
6
DPO4_SULSO
A:
[8-267]
------
I
V
L
F
V
D
F
D
Y
F
Y
A
Q
V
E
E
V
L
N
P
S
L
K
G
K
P
V
V
V
C
V
F
S
--
G
R
F
E
D
S
G
A
V
A
T
A
N
Y
E
A
R
K
F
G
V
K
A
G
I
P
I
V
E
A
K
K
I
L
P
N
A
V
Y
L
P
-------
M
R
K
E
V
Y
Q
Q
V
S
S
R
I
M
-
N
L
L
R
E
Y
S
E
K
I
E
I
A
S
I
D
E
A
Y
L
D
I
S
D
K
V
-
R
-----
D
-
Y
-
R
E
---------------------------------------------------
A
Y
N
L
G
L
E
I
K
N
K
I
L
E
K
E
K
I
T
V
T
V
G
I
S
K
N
K
V
F
A
K
I
A
A
D
M
A
K
P
N
G
I
K
V
I
D
D
E
E
V
K
R
L
I
R
E
L
D
I
A
D
V
P
G
I
G
N
I
T
A
E
-
K
L
K
K
L
G
I
N
K
L
V
D
T
L
S
I
E
F
D
K
L
K
G
M
I
G
E
A
K
-
A
K
Y
-
L
I
S
L
A
R
D
E
Y
N
E
P
I
---
R
T
R
V
R
K
S
I
G
R
I
V
T
M
K
R
N
--
S
R
N
L
E
E
I
----------------------------------------------------------------------------------------------------------------------------------------------------------------------
33
PsiBlast_CBE
55.48
33%
3
- C3 -
4RZR
8
?
D:
[2-261]
------
I
V
L
F
V
D
F
D
Y
F
Y
A
Q
V
E
E
V
L
N
P
S
L
K
G
K
P
V
V
V
C
VF
S
--
G
R
F
E
D
S
G
A
V
A
T
A
N
Y
E
A
R
K
F
G
V
K
A
G
I
P
I
V
E
A
K
K
I
L
P
N
A
V
Y
L
P
-------
M
R
K
E
V
Y
Q
Q
V
S
S
R
I
M
-
N
L
L
R
E
Y
S
E
K
I
E
I
A
S
I
D
E
A
Y
L
D
I
S
D
K
V
-
R
-----
D
-
Y
-
R
E---------------------------------------------------
A
Y
N
L
G
L
E
I
K
N
K
I
L
E
K
E
K
I
T
V
T
V
G
I
S
K
N
K
V
F
A
K
I
A
A
D
M
A
K
P
N
G
I
K
V
I
D
D
E
E
V
K
R
L
I
R
E
L
D
I
A
D
V
P
G
I
G
N
I
T
A
E
-
K
L
K
K
L
G
I
N
K
L
V
D
T
L
S
I
E
F
D
K
L
K
G
M
I
G
E
A
K
-
A
K
Y
-
L
I
S
L
A
R
D
E
Y
N
E
P
I
---
R
T
R
V
R
K
S
I
G
R
I
V
T
M
K
R
N
--
S
R
N
L
E
E
I
----------------------------------------------------------------------------------------------------------------------------------------------------------------------
82
PsiBlast_CBE
55.40
33%
3
- C3 -
1S9F
5
DPO4_SULSO
D:
[2-261]
------
I
V
L
F
V
D
F
D
Y
F
Y
A
Q
V
E
E
V
L
N
P
S
L
K
G
K
P
V
V
V
C
VF
S
--
G
R
F
E
D
S
G
A
V
A
T
A
N
Y
E
A
R
K
F
G
V
K
A
G
I
P
I
V
E
A
K
K
I
L
P
N
A
V
Y
L
P
-------
M
R
K
E
V
Y
Q
Q
V
S
S
R
I
M
-
N
L
L
R
E
Y
S
E
K
I
E
I
A
S
I
D
E
A
Y
L
D
I
S
D
K
V
-
R
-----
D
-
Y
-
R
E---------------------------------------------------
A
Y
N
L
G
L
E
I
K
N
K
I
L
E
K
E
K
I
T
V
T
V
G
I
S
K
N
K
V
F
A
K
I
A
A
D
M
A
K
P
N
G
I
K
V
I
D
D
E
E
V
K
R
L
I
R
E
L
D
I
A
D
V
P
G
I
G
N
I
T
A
E
-
K
L
K
K
L
G
I
N
K
L
V
D
T
L
S
I
E
F
D
K
L
K
G
M
I
G
E
A
K
-
A
K
Y
-
L
I
S
L
A
R
D
E
Y
N
E
P
I
---
R
T
R
V
R
K
S
I
G
R
I
V
T
M
K
R
N
--
S
R
N
L
E
E
I
----------------------------------------------------------------------------------------------------------------------------------------------------------------------
90
PsiBlast_CBE
55.38
33%
8
- C3 -
1S10
5
DPO4_SULSO
A:
[2-261]
------
I
V
L
F
V
D
F
D
Y
F
Y
A
Q
V
E
E
V
L
N
P
S
L
K
G
K
P
V
V
V
C
V
F
S
--
G
R
F
E
D
S
G
A
V
A
T
A
N
Y
E
A
R
K
F
G
V
K
A
G
I
P
I
V
E
A
K
K
I
L
P
N
A
V
Y
L
P
-------
M
R
K
E
V
Y
Q
Q
V
S
S
R
I
M
-
N
L
L
R
E
Y
S
E
K
I
E
I
A
S
I
D
E
A
Y
L
D
I
S
D
K
V
-
R
-----
D
-
Y
-
R
E
---------------------------------------------------
A
Y
N
L
G
L
E
I
K
N
K
I
L
E
K
E
K
I
T
V
T
V
G
I
S
K
N
K
V
F
A
K
I
A
A
D
M
A
K
P
N
G
I
K
V
I
D
D
E
E
V
K
R
L
I
R
E
L
D
I
A
D
V
P
G
I
G
N
I
T
A
E
-
K
L
K
K
L
G
I
N
K
L
V
D
T
L
S
I
E
F
D
K
L
K
G
M
I
G
E
A
K
-
A
K
Y
-
L
I
S
L
A
R
D
E
Y
N
E
P
I
---
R
T
R
V
R
K
S
I
G
R
I
V
T
M
K
R
N
--
S
R
N
L
E
E
I
----------------------------------------------------------------------------------------------------------------------------------------------------------------------
57
PsiBlast_CBE
55.34
33%
6
- C3 -
2V4Q
6
DPO4_SULSO
A:
[8-267]
------
I
V
L
F
V
D
F
D
Y
F
Y
A
Q
V
E
E
V
L
N
P
S
L
K
G
K
P
V
V
V
C
V
F
S
--
G
R
F
E
D
S
G
A
V
A
T
A
N
Y
E
A
R
K
F
G
V
K
A
G
I
P
I
V
E
A
K
K
I
L
P
N
A
V
Y
L
P
-------
M
R
K
E
V
Y
Q
Q
V
S
S
R
I
M
-
N
L
L
R
E
Y
S
E
K
I
E
I
A
S
I
D
E
A
Y
L
D
I
S
D
K
V
-
R
-----
D
-
Y
-
R
E
---------------------------------------------------
A
Y
N
L
G
L
E
I
K
N
K
I
L
E
K
E
K
I
T
V
T
V
G
I
S
K
N
K
V
F
A
K
I
A
A
D
M
A
K
P
N
G
I
K
V
I
D
D
E
E
V
K
R
L
I
R
E
L
D
I
A
D
V
P
G
I
G
N
I
T
A
E
-
K
L
K
K
L
G
I
N
K
L
V
D
T
L
S
I
E
F
D
K
L
K
G
M
I
G
E
A
K
-
A
K
Y
-
L
I
S
L
A
R
D
E
Y
N
E
P
I
---
R
T
R
V
R
K
S
I
G
R
I
V
T
M
K
R
N
--
S
R
N
L
E
E
I
----------------------------------------------------------------------------------------------------------------------------------------------------------------------
75
PsiBlast_CBE
55.30
33%
11
- C3 -
2C2D
7
DPO4_SULSO
A:
[8-267]
------
I
V
L
F
V
D
F
D
Y
F
Y
A
Q
V
E
E
V
L
N
P
S
L
K
G
K
P
V
V
V
C
V
F
S
--
G
R
F
E
D
S
G
A
V
A
T
A
N
Y
E
A
R
K
F
G
V
K
A
G
I
P
I
V
E
A
K
K
I
L
P
N
A
V
Y
L
P
-------
M
R
K
E
V
Y
Q
Q
V
S
S
R
I
M
-
N
L
L
R
E
Y
S
E
K
I
E
I
A
S
I
D
E
A
Y
L
D
I
S
D
K
V
-
R
-----
D
-
Y
-
R
E
---------------------------------------------------
A
Y
N
L
G
L
E
I
K
N
K
I
L
E
K
E
K
I
T
V
T
V
G
I
S
K
N
K
V
F
A
K
I
A
A
D
M
A
K
P
N
G
I
K
V
I
D
D
E
E
V
K
R
L
I
R
E
L
D
I
A
D
V
P
G
I
G
N
I
T
A
E
-
K
L
K
K
L
G
I
N
K
L
V
D
T
L
S
I
E
F
D
K
L
K
G
M
I
G
E
A
K
-
A
K
Y
-
L
I
S
L
A
R
D
E
Y
N
E
P
I
---
R
T
R
V
R
K
S
I
G
R
I
V
T
M
K
R
N
--
S
R
N
L
E
E
I
----------------------------------------------------------------------------------------------------------------------------------------------------------------------
35
PsiBlast_CBE
55.28
33%
8
- C3 -
4GC7
6
?
B:
[9-268]
------
I
V
L
F
V
D
F
D
Y
F
Y
A
Q
V
E
E
V
L
N
P
S
L
K
G
K
P
V
V
V
C
VF
S
--
G
R
F
E
D
S
G
A
V
A
T
A
N
Y
E
A
R
K
F
G
V
K
A
G
I
P
I
V
E
A
K
K
I
L
P
N
A
V
Y
L
P
-------
M
R
K
E
V
Y
Q
Q
V
S
S
R
I
M
-
N
L
L
R
E
Y
S
E
K
I
E
I
A
S
I
D
E
A
Y
L
D
I
S
D
K
V
-
R
-----
D
-
Y
-
R
E---------------------------------------------------
A
Y
N
L
G
L
E
I
K
N
K
I
L
E
K
E
K
I
T
V
T
V
G
I
S
K
N
K
V
F
A
K
I
A
A
D
M
A
K
P
N
G
I
K
V
I
D
D
E
E
V
K
R
L
I
R
E
L
D
I
A
D
V
P
G
I
G
N
I
T
A
E
-
K
L
K
K
L
G
I
N
K
L
V
D
T
L
S
I
E
F
D
K
L
K
G
M
I
G
E
A
K
-
A
K
Y
-
L
I
S
L
A
R
D
E
Y
N
E
P
I
---
R
T
R
V
R
K
S
I
G
R
I
V
T
M
K
R
N
--
S
R
N
L
E
E
I
----------------------------------------------------------------------------------------------------------------------------------------------------------------------
91
PsiBlast_CBE
55.27
33%
7
- C3 -
1S0O
8
DPO4_SULSO
B:
[2-261]
------
I
V
L
F
V
D
F
D
Y
F
Y
A
Q
V
E
E
V
L
N
P
S
L
K
G
K
P
V
V
V
C
VF
S
--
G
R
F
E
D
S
G
A
V
A
T
A
N
Y
E
A
R
K
F
G
V
K
A
G
I
P
I
V
E
A
K
K
I
L
P
N
A
V
Y
L
P
-------
M
R
K
E
V
Y
Q
Q
V
S
S
R
I
M
-
N
L
L
R
E
Y
S
E
K
I
E
I
A
S
I
D
E
A
Y
L
D
I
S
D
K
V
-
R
-----
D
-
Y
-
R
E---------------------------------------------------
A
Y
N
L
G
L
E
I
K
N
K
I
L
E
K
E
K
I
T
V
T
V
G
I
S
K
N
K
V
F
A
K
I
A
A
D
M
A
K
P
N
G
I
K
V
I
D
D
E
E
V
K
R
L
I
R
E
L
D
I
A
D
V
P
G
I
G
N
I
T
A
E
-
K
L
K
K
L
G
I
N
K
L
V
D
T
L
S
I
E
F
D
K
L
K
G
M
I
G
E
A
K
-
A
K
Y
-
L
I
S
L
A
R
D
E
Y
N
E
P
I
---
R
T
R
V
R
K
S
I
G
R
I
V
T
M
K
R
N
--
S
R
N
L
E
E
I
----------------------------------------------------------------------------------------------------------------------------------------------------------------------
34
PsiBlast_CBE
55.26
33%
2
- C3 -
4RZR
5
DPO4_SULSO
A:
[2-261]
------
I
V
L
F
V
D
F
D
Y
F
Y
A
Q
V
E
E
V
L
N
P
S
L
K
G
K
P
V
V
V
C
VF
S
--
G
R
F
E
D
S
G
A
V
A
T
A
N
Y
E
A
R
K
F
G
V
K
A
G
I
P
I
V
E
A
K
K
I
L
P
N
A
V
Y
L
P
-------
M
R
K
E
V
Y
Q
Q
V
S
S
R
I
M
-
N
L
L
R
E
Y
S
E
K
I
E
I
A
S
I
D
E
A
Y
L
D
I
S
D
K
V
-
R
-----
D
-
Y
-
R
E
---------------------------------------------------
A
Y
N
L
G
L
E
I
K
N
K
I
L
E
K
E
K
I
T
V
T
V
G
I
S
K
N
K
V
F
A
K
I
A
A
D
M
A
K
P
N
G
I
K
V
I
D
D
E
E
V
K
R
L
I
R
E
L
D
I
A
D
V
P
G
I
G
N
I
T
A
E
-
K
L
K
K
L
G
I
N
K
L
V
D
T
L
S
I
E
F
D
K
L
K
G
M
I
G
E
A
K
-
A
K
Y
-
L
I
S
L
A
R
D
E
Y
N
E
P
I
---
R
T
R
V
R
K
S
I
G
R
I
V
T
M
K
R
N
--
S
R
N
L
E
E
I
----------------------------------------------------------------------------------------------------------------------------------------------------------------------
80
PsiBlast_CBE
55.21
33%
7
- C3 -
2BQR
6
DPO4_SULSO
A:
[8-267]
------
I
V
L
F
V
D
F
D
Y
F
Y
A
Q
V
E
E
V
L
N
P
S
L
K
G
K
P
V
V
V
C
V
F
S
--
G
R
F
E
D
S
G
A
V
A
T
A
N
Y
E
A
R
K
F
G
V
K
A
G
I
P
I
V
E
A
K
K
I
L
P
N
A
V
Y
L
P
-------
M
R
K
E
V
Y
Q
Q
V
S
S
R
I
M
-
N
L
L
R
E
Y
S
E
K
I
E
I
A
S
I
D
E
A
Y
L
D
I
S
D
K
V
-
R
-----
D
-
Y
-
R
E
---------------------------------------------------
A
Y
N
L
G
L
E
I
K
N
K
I
L
E
K
E
K
I
T
V
T
V
G
I
S
K
N
K
V
F
A
K
I
A
A
D
M
A
K
P
N
G
I
K
V
I
D
D
E
E
V
K
R
L
I
R
E
L
D
I
A
D
V
P
G
I
G
N
I
T
A
E
-
K
L
K
K
L
G
I
N
K
L
V
D
T
L
S
I
E
F
D
K
L
K
G
M
I
G
E
A
K
-
A
K
Y
-
L
I
S
L
A
R
D
E
Y
N
E
P
I
---
R
T
R
V
R
K
S
I
G
R
I
V
T
M
K
R
N
--
S
R
N
L
E
E
I
----------------------------------------------------------------------------------------------------------------------------------------------------------------------
68
PsiBlast_CBE
55.13
33%
6
- C3 -
2J6T
6
DPO4_SULSO
A:
[8-267]
------
I
V
L
F
V
D
F
D
Y
F
Y
A
Q
V
E
E
V
L
N
P
S
L
K
G
K
P
V
V
V
C
V
F
S
--
G
R
F
E
D
S
G
A
V
A
T
A
N
Y
E
A
R
K
F
G
V
K
A
G
I
P
I
V
E
A
K
K
I
L
P
N
A
V
Y
L
P
-------
M
R
K
E
V
Y
Q
Q
V
S
S
R
I
M
-
N
L
L
R
E
Y
S
E
K
I
E
I
A
S
I
D
E
A
Y
L
D
I
S
D
K
V
-
R
-----
D
-
Y
-
R
E
---------------------------------------------------
A
Y
N
L
G
L
E
I
K
N
K
I
L
E
K
E
K
I
T
V
T
V
G
I
S
K
N
K
V
F
A
K
I
A
A
D
M
A
K
P
N
G
I
K
V
I
D
D
E
E
V
K
R
L
I
R
E
L
D
I
A
D
V
P
G
I
G
N
I
T
A
E
-
K
L
K
K
L
G
I
N
K
L
V
D
T
L
S
I
E
F
D
K
L
K
G
M
I
G
E
A
K
-
A
K
Y
-
L
I
S
L
A
R
D
E
Y
N
E
P
I
---
R
T
R
V
R
K
S
I
G
R
I
V
T
M
K
R
N
--
S
R
N
L
E
E
I
----------------------------------------------------------------------------------------------------------------------------------------------------------------------
20
PsiBlast_PDB
55.12
33%
9
- C3 -
1S0M
6
DPO4_SULSO
A:
[2-261]
------
I
V
L
F
V
D
F
D
Y
F
Y
A
Q
V
E
E
V
L
N
P
S
L
K
G
K
P
V
V
V
C
V
F
S
--
G
R
F
E
D
S
G
A
V
A
T
A
N
Y
E
A
R
K
F
G
V
K
A
G
I
P
I
V
E
A
K
K
I
L
P
N
A
V
Y
L
P
-------
M
R
K
E
V
Y
Q
Q
V
S
S
R
I
M
-
N
L
L
R
E
Y
S
E
K
I
E
I
A
S
I
D
E
A
Y
L
D
I
S
D
K
V
-
R
-----
D
-
Y
-
R
E
---------------------------------------------------
A
Y
N
L
G
L
E
I
K
N
K
I
L
E
K
E
K
I
T
V
T
V
G
I
S
K
N
K
V
F
A
K
I
A
A
D
M
A
K
P
N
G
I
K
V
I
D
D
E
E
V
K
R
L
I
R
E
L
D
I
A
D
V
P
G
I
G
N
I
T
A
E
-
K
L
K
K
L
G
I
N
K
L
V
D
T
L
S
I
E
F
D
K
L
K
G
M
I
G
E
A
K
-
A
K
Y
-
L
I
S
L
A
R
D
E
Y
N
E
P
I
---
R
T
R
V
R
K
S
I
G
R
I
V
T
M
K
R
N
--
S
R
N
L
E
E
I
----------------------------------------------------------------------------------------------------------------------------------------------------------------------
78
PsiBlast_CBE
55.08
33%
8
- C3 -
2BR0
6
DPO4_SULSO
A:
[8-267]
------
I
V
L
F
V
D
F
D
Y
F
Y
A
Q
V
E
E
V
L
N
P
S
L
K
G
K
P
V
V
V
C
VF
S
--
G
R
F
E
D
S
G
A
V
A
T
A
N
Y
E
A
R
K
F
G
V
K
A
G
I
P
I
V
E
A
K
K
I
L
P
N
A
V
Y
L
P
-------
M
R
K
E
V
Y
Q
Q
V
S
S
R
I
M
-
N
L
L
R
E
Y
S
E
K
I
E
I
A
S
I
D
E
A
Y
L
D
I
S
D
K
V
-
R
-----
D
-
Y
-
R
E
---------------------------------------------------
A
Y
N
L
G
L
E
I
K
N
K
I
L
E
K
E
K
I
T
V
T
V
G
I
S
K
N
K
V
F
A
K
I
A
A
D
M
A
K
P
N
G
I
K
V
I
D
D
E
E
V
K
R
L
I
R
E
L
D
I
A
D
V
P
G
I
G
N
I
T
A
E
-
K
L
K
K
L
G
I
N
K
L
V
D
T
L
S
I
E
F
D
K
L
K
G
M
I
G
E
A
K
-
A
K
Y
-
L
I
S
L
A
R
D
E
Y
N
E
P
I
---
R
T
R
V
R
K
S
I
G
R
I
V
T
M
K
R
N
--
S
R
N
L
E
E
I
----------------------------------------------------------------------------------------------------------------------------------------------------------------------
67
PsiBlast_CBE
55.06
33%
4
- C3 -
2J6U
6
DPO4_SULSO
A:
[8-267]
------
I
V
L
F
V
D
F
D
Y
F
Y
A
Q
V
E
E
V
L
N
P
S
L
K
G
K
P
V
V
V
C
V
F
S
--
G
R
F
E
D
S
G
A
V
A
T
A
N
Y
E
A
R
K
F
G
V
K
A
G
I
P
I
V
E
A
K
K
I
L
P
N
A
V
Y
L
P
-------
M
R
K
E
V
Y
Q
Q
V
S
S
R
I
M
-
N
L
L
R
E
Y
S
E
K
I
E
I
A
S
I
D
E
A
Y
L
D
I
S
D
K
V
-
R
-----
D
-
Y
-
R
E
---------------------------------------------------
A
Y
N
L
G
L
E
I
K
N
K
I
L
E
K
E
K
I
T
V
T
V
G
I
S
K
N
K
V
F
A
K
I
A
A
D
M
A
K
P
N
G
I
K
V
I
D
D
E
E
V
K
R
L
I
R
E
L
D
I
A
D
V
P
G
I
G
N
I
T
A
E
-
K
L
K
K
L
G
I
N
K
L
V
D
T
L
S
I
E
F
D
K
L
K
G
M
I
G
E
A
K
-
A
K
Y
-
L
I
S
L
A
R
D
E
Y
N
E
P
I
---
R
T
R
V
R
K
S
I
G
R
I
V
T
M
K
R
N
--
S
R
N
L
E
E
I
----------------------------------------------------------------------------------------------------------------------------------------------------------------------
15
PsiBlast_PDB
55.04
33%
9
- C3 -
1JXL
7
DPO4_SULSO
A:
[2-261]
------
I
V
L
F
V
D
F
D
Y
F
Y
A
Q
V
E
E
V
L
N
P
S
L
K
G
K
P
V
V
V
C
V
F
S
--
G
R
F
E
D
S
G
A
V
A
T
A
N
Y
E
A
R
K
F
G
V
K
A
G
I
P
I
V
E
A
K
K
I
L
P
N
A
V
Y
L
P
-------
M
R
K
E
V
Y
Q
Q
V
S
S
R
I
M
-
N
L
L
R
E
Y
S
E
K
I
E
I
A
S
I
D
E
A
Y
L
D
I
S
D
K
V
-
R
-----
D
-
Y
-
R
E
---------------------------------------------------
A
Y
N
L
G
L
E
I
K
N
K
I
L
E
K
E
K
I
T
V
T
V
G
I
S
K
N
K
V
F
A
K
I
A
A
D
M
A
K
P
N
G
I
K
V
I
D
D
E
E
V
K
R
L
I
R
E
L
D
I
A
D
V
P
G
I
G
N
I
T
A
E
-
K
L
K
K
L
G
I
N
K
L
V
D
T
L
S
I
E
F
D
K
L
K
G
M
I
G
E
A
K
-
A
K
Y
-
L
I
S
L
A
R
D
E
Y
N
E
P
I
---
R
T
R
V
R
K
S
I
G
R
I
V
T
M
K
R
N
--
S
R
N
L
E
E
I
----------------------------------------------------------------------------------------------------------------------------------------------------------------------
77
PsiBlast_CBE
55.00
33%
10
- C3 -
2C22
6
DPO4_SULSO
A:
[8-267]
------
I
V
L
F
V
D
F
D
Y
F
Y
A
Q
V
E
E
V
L
N
P
S
L
K
G
K
P
V
V
V
C
V
F
S
--
G
R
F
E
D
S
G
A
V
A
T
A
N
Y
E
A
R
K
F
G
V
K
A
G
I
P
I
V
E
A
K
K
I
L
P
N
A
V
Y
L
P
-------
M
R
K
E
V
Y
Q
Q
V
S
S
R
I
M
-
N
L
L
R
E
Y
S
E
K
I
E
I
A
S
I
D
E
A
Y
L
D
I
S
D
K
V
-
R
-----
D
-
Y
-
R
E
---------------------------------------------------
A
Y
N
L
G
L
E
I
K
N
K
I
L
E
K
E
K
I
T
V
T
V
G
I
S
K
N
K
V
F
A
K
I
A
A
D
M
A
K
P
N
G
I
K
V
I
D
D
E
E
V
K
R
L
I
R
E
L
D
I
A
D
V
P
G
I
G
N
I
T
A
E
-
K
L
K
K
L
G
I
N
K
L
V
D
T
L
S
I
E
F
D
K
L
K
G
M
I
G
E
A
K
-
A
K
Y
-
L
I
S
L
A
R
D
E
Y
N
E
P
I
---
R
T
R
V
R
K
S
I
G
R
I
V
T
M
K
R
N
--
S
R
N
L
E
E
I
----------------------------------------------------------------------------------------------------------------------------------------------------------------------
45
PsiBlast_CBE
54.98
33%
9
- C3 -
2XC9
2
DPO4_SULSO
A:
[8-267]
------
I
V
L
F
V
D
F
D
Y
F
Y
A
Q
V
E
E
V
L
N
P
S
L
K
G
K
P
V
V
V
C
V
F
S
--
G
R
F
E
D
S
G
A
V
A
T
A
N
Y
E
A
R
K
F
G
V
K
A
G
I
P
I
V
E
A
K
K
I
L
P
N
A
V
Y
L
P
-------
M
R
K
E
V
Y
Q
Q
V
S
S
R
I
M
-
N
L
L
R
E
Y
S
E
K
I
E
I
A
S
I
D
E
A
Y
L
D
I
S
D
K
V
-
R
-----
D
-
Y
-
R
E
---------------------------------------------------
A
Y
N
L
G
L
E
I
K
N
K
I
L
E
K
E
K
I
T
V
T
V
G
I
S
K
N
K
V
F
A
K
I
A
A
D
M
A
K
P
N
G
I
K
V
I
D
D
E
E
V
K
R
L
I
R
E
L
D
I
A
D
V
P
G
I
G
N
I
T
A
E
-
K
L
K
K
L
G
I
N
K
L
V
D
T
L
S
I
E
F
D
K
L
K
G
M
I
G
E
A
K
-
A
K
Y
-
L
I
S
L
A
R
D
E
Y
N
E
P
I
---
R
T
R
V
R
K
S
I
G
R
I
V
T
M
K
R
N
--
S
R
N
L
E
E
I
----------------------------------------------------------------------------------------------------------------------------------------------------------------------
19
PsiBlast_PDB
54.93
33%
11
- C3 -
1RYS
5
DPO4_SULSO
A:
[2-261]
------
I
V
L
F
V
D
F
D
Y
F
Y
A
Q
V
E
E
V
L
N
P
S
L
K
G
K
P
V
V
V
C
V
F
S
--
G
R
F
E
D
S
G
A
V
A
T
A
N
Y
E
A
R
K
F
G
V
K
A
G
I
P
I
V
E
A
K
K
I
L
P
N
A
V
Y
L
P
-------
M
R
K
E
V
Y
Q
Q
V
S
S
R
I
M
-
N
L
L
R
E
Y
S
E
K
I
E
I
A
S
I
D
E
A
Y
L
D
I
S
D
K
V
-
R
-----
D
-
Y
-
R
E
---------------------------------------------------
A
Y
N
L
G
L
E
I
K
N
K
I
L
E
K
E
K
I
T
V
T
V
G
I
S
K
N
K
V
F
A
K
I
A
A
D
M
A
K
P
N
G
I
K
V
I
D
D
E
E
V
K
R
L
I
R
E
L
D
I
A
D
V
P
G
I
G
N
I
T
A
E
-
K
L
K
K
L
G
I
N
K
L
V
D
T
L
S
I
E
F
D
K
L
K
G
M
I
G
E
A
K
-
A
K
Y
-
L
I
S
L
A
R
D
E
Y
N
E
P
I
---
R
T
R
V
R
K
S
I
G
R
I
V
T
M
K
R
N
--
S
R
N
L
E
E
I
----------------------------------------------------------------------------------------------------------------------------------------------------------------------
94
PsiBlast_CBE
54.89
33%
6
- C3 -
1S0M
8
DPO4_SULSO
B:
[2-261]
------
I
V
L
F
V
D
F
D
Y
F
Y
A
Q
V
E
E
V
L
N
P
S
L
K
G
K
P
V
V
V
C
VF
S
--
G
R
F
E
D
S
G
A
V
A
T
A
N
Y
E
A
R
K
F
G
V
K
A
G
I
P
I
V
E
A
K
K
I
L
P
N
A
V
Y
L
P
-------
M
R
K
E
V
Y
Q
Q
V
S
S
R
I
M
-
N
L
L
R
E
Y
S
E
K
I
E
I
A
S
I
D
E
A
Y
L
D
I
S
D
K
V
-
R
-----
D
-
Y
-
R
E---------------------------------------------------
A
Y
N
L
G
L
E
I
K
N
K
I
L
E
K
E
K
I
T
V
T
V
G
I
S
K
N
K
V
F
A
K
I
A
A
D
M
A
K
P
N
G
I
K
V
I
D
D
E
E
V
K
R
L
I
R
E
L
D
I
A
D
V
P
G
I
G
N
I
T
A
E
-
K
L
K
K
L
G
I
N
K
L
V
D
T
L
S
I
E
F
D
K
L
K
G
M
I
G
E
A
K
-
A
K
Y
-
L
I
S
L
A
R
D
E
Y
N
E
P
I
---
R
T
R
V
R
K
S
I
G
R
I
V
T
M
K
R
N
--
S
R
N
L
E
E
I
----------------------------------------------------------------------------------------------------------------------------------------------------------------------
62
PsiBlast_CBE
54.87
33%
11
- C3 -
2R8G
6
DPO4_SULSO
A:
[2-261]
------
I
V
L
F
V
D
F
D
Y
F
Y
A
Q
V
E
E
V
L
N
P
S
L
K
G
K
P
V
V
V
C
V
F
S
--
G
R
F
E
D
S
G
A
V
A
T
A
N
Y
E
A
R
K
F
G
V
K
A
G
I
P
I
V
E
A
K
K
I
L
P
N
A
V
Y
L
P
-------
M
R
K
E
V
Y
Q
Q
V
S
S
R
I
M
-
N
L
L
R
E
Y
S
E
K
I
E
I
A
S
I
D
E
A
Y
L
D
I
S
D
K
V
-
R
-----
D
-
Y
-
R
E
---------------------------------------------------
A
Y
N
L
G
L
E
I
K
N
K
I
L
E
K
E
K
I
T
V
T
V
G
I
S
K
N
K
V
F
A
K
I
A
A
D
M
A
K
P
N
G
I
K
V
I
D
D
E
E
V
K
R
L
I
R
E
L
D
I
A
D
V
P
G
I
G
N
I
T
A
E
-
K
L
K
K
L
G
I
N
K
L
V
D
T
L
S
I
E
F
D
K
L
K
G
M
I
G
E
A
K
-
A
K
Y
-
L
I
S
L
A
R
D
E
Y
N
E
P
I
---
R
T
R
V
R
K
S
I
G
R
I
V
T
M
K
R
N
--
S
R
N
L
E
E
I
----------------------------------------------------------------------------------------------------------------------------------------------------------------------
79
PsiBlast_CBE
54.72
33%
9
- C3 -
2BQU
6
DPO4_SULSO
A:
[8-267]
------
I
V
L
F
V
D
F
D
Y
F
Y
A
Q
V
E
E
V
L
N
P
S
L
K
G
K
P
V
V
V
C
V
F
S
--
G
R
F
E
D
S
G
A
V
A
T
A
N
Y
E
A
R
K
F
G
V
K
A
G
I
P
I
V
E
A
K
K
I
L
P
N
A
V
Y
L
P
-------
M
R
K
E
V
Y
Q
Q
V
S
S
R
I
M
-
N
L
L
R
E
Y
S
E
K
I
E
I
A
S
I
D
E
A
Y
L
D
I
S
D
K
V
-
R
-----
D
-
Y
-
R
E
---------------------------------------------------
A
Y
N
L
G
L
E
I
K
N
K
I
L
E
K
E
K
I
T
V
T
V
G
I
S
K
N
K
V
F
A
K
I
A
A
D
M
A
K
P
N
G
I
K
V
I
D
D
E
E
V
K
R
L
I
R
E
L
D
I
A
D
V
P
G
I
G
N
I
T
A
E
-
K
L
K
K
L
G
I
N
K
L
V
D
T
L
S
I
E
F
D
K
L
K
G
M
I
G
E
A
K
-
A
K
Y
-
L
I
S
L
A
R
D
E
Y
N
E
P
I
---
R
T
R
V
R
K
S
I
G
R
I
V
T
M
K
R
N
--
S
R
N
L
E
E
I
----------------------------------------------------------------------------------------------------------------------------------------------------------------------
42
PsiBlast_CBE
54.69
33%
5
- C3 -
2XCP
5
DPO4_SULSO
B:
[8-267]
------
I
V
L
F
V
D
F
D
Y
F
Y
A
Q
V
E
E
V
L
N
P
S
L
K
G
K
P
V
V
V
C
V
F
S
--
G
R
F
E
D
S
G
A
V
A
T
A
N
Y
E
A
R
K
F
G
V
K
A
G
I
P
I
V
E
A
K
K
I
L
P
N
A
V
Y
L
P
-------
M
R
K
E
V
Y
Q
Q
V
S
S
R
I
M
-
N
L
L
R
E
Y
S
E
K
I
E
I
A
S
I
D
E
A
Y
L
D
I
S
D
K
V
-
R
-----
D
-
Y
-
R
E
---------------------------------------------------
A
Y
N
L
G
L
E
I
K
N
K
I
L
E
K
E
K
I
T
V
T
V
G
I
S
K
N
K
V
F
A
K
I
A
A
D
M
A
K
P
N
G
I
K
V
I
D
D
E
E
V
K
R
L
I
R
E
L
D
I
A
D
V
P
G
I
G
N
I
T
A
E
-
K
L
K
K
L
G
I
N
K
L
V
D
T
L
S
I
E
F
D
K
L
K
G
M
I
G
E
A
K
-
A
K
Y
-
L
I
S
L
A
R
D
E
Y
N
E
P
I
---
R
T
R
V
R
K
S
I
G
R
I
V
T
M
K
R
N
--
S
R
N
L
E
E
I
----------------------------------------------------------------------------------------------------------------------------------------------------------------------
41
PsiBlast_CBE
54.55
33%
-0
- C3 -
3FDS
16
DPO4_SULSO
A:
[2-261]
------
I
V
L
F
V
D
F
D
Y
F
Y
A
Q
V
E
E
V
L
N
P
S
L
K
G
K
P
V
V
V
C
VF
S
--
G
R
F
E
D
S
G
A
V
A
T
A
N
Y
E
A
R
K
F
G
V
K
A
G
I
P
I
V
E
A
K
K
I
L
P
N
A
V
Y
L
P
-------
M
R
K
E
V
Y
Q
Q
V
S
S
R
I
M
-
N
L
L
R
E
Y
S
E
K
I
E
I
A
S
I
D
E
A
Y
L
D
I
S
D
K
V
-
R
-----
D
-
Y
-
R
E
---------------------------------------------------
A
Y
N
L
G
L
E
I
K
N
K
I
L
E
K
E
K
I
T
V
T
V
G
I
S
K
N
K
V
F
A
K
I
A
A
D
M
A
K
P
N
G
I
K
V
I
D
D
E
E
V
K
R
L
I
R
E
L
D
I
A
D
V
P
G
I
G
N
I
T
A
E
-
K
L
K
K
L
G
I
N
K
L
V
D
T
L
S
I
E
F
D
K
L
K
G
M
I
G
E
A
K
-
A
K
Y
-
L
I
S
L
A
R
D
E
Y
N
E
P
I
---
R
T
R
V
R
K
S
I
G
R
I
V
T
M
K
R
N
--
S
R
N
L
E
E
I
----------------------------------------------------------------------------------------------------------------------------------------------------------------------
40
PsiBlast_CBE
54.50
33%
12
- C3 -
3M9M
8
DPO4_SULSO
B:
[2-261]
------
I
V
L
F
V
D
F
D
Y
F
Y
A
Q
V
E
E
V
L
N
P
S
L
K
G
K
P
V
V
V
C
VF
S
--
G
R
F
E
D
S
G
A
V
A
T
A
N
Y
E
A
R
K
F
G
V
K
A
G
I
P
I
V
E
A
K
K
I
L
P
N
A
V
Y
L
P
-------
M
R
K
E
V
Y
Q
Q
V
S
S
R
I
M
-
N
L
L
R
E
Y
S
E
K
I
E
I
A
S
I
D
E
A
Y
L
D
I
S
D
K
V
-
R
-----
D
-
Y
-
R
E---------------------------------------------------
A
Y
N
L
G
L
E
I
K
N
K
I
L
E
K
E
K
I
T
V
T
V
G
I
S
K
N
K
V
F
A
K
I
A
A
D
M
A
K
P
N
G
I
K
V
I
D
D
E
E
V
K
R
L
I
R
E
L
D
I
A
D
V
P
G
I
G
N
I
T
A
E
-
K
L
K
K
L
G
I
N
K
L
V
D
T
L
S
I
E
F
D
K
L
K
G
M
I
G
E
A
K
-
A
K
Y
-
L
I
S
L
A
R
D
E
Y
N
E
P
I
---
R
T
R
V
R
K
S
I
G
R
I
V
T
M
K
R
N
--
S
R
N
L
E
E
I
----------------------------------------------------------------------------------------------------------------------------------------------------------------------
70
PsiBlast_CBE
54.48
33%
8
- C3 -
2IBK
7
DPO4_SULSO
A:
[2-261]
------
I
V
L
F
V
D
F
D
Y
F
Y
A
Q
V
E
E
V
L
N
P
S
L
K
G
K
P
V
V
V
C
V
F
S
--
G
R
F
E
D
S
G
A
V
A
T
A
N
Y
E
A
R
K
F
G
V
K
A
G
I
P
I
V
E
A
K
K
I
L
P
N
A
V
Y
L
P
-------
M
R
K
E
V
Y
Q
Q
V
S
S
R
I
M
-
N
L
L
R
E
Y
S
E
K
I
E
I
A
S
I
D
E
A
Y
L
D
I
S
D
K
V
-
R
-----
D
-
Y
-
R
E
---------------------------------------------------
A
Y
N
L
G
L
E
I
K
N
K
I
L
E
K
E
K
I
T
V
T
V
G
I
S
K
N
K
V
F
A
K
I
A
A
D
M
A
K
P
N
G
I
K
V
I
D
D
E
E
V
K
R
L
I
R
E
L
D
I
A
D
V
P
G
I
G
N
I
T
A
E
-
K
L
K
K
L
G
I
N
K
L
V
D
T
L
S
I
E
F
D
K
L
K
G
M
I
G
E
A
K
-
A
K
Y
-
L
I
S
L
A
R
D
E
Y
N
E
P
I
---
R
T
R
V
R
K
S
I
G
R
I
V
T
M
K
R
N
--
S
R
N
L
E
E
I
----------------------------------------------------------------------------------------------------------------------------------------------------------------------
83
PsiBlast_CBE
54.44
33%
6
- C3 -
1S9F
5
DPO4_SULSO
C:
[2-261]
------
I
V
L
F
V
D
F
D
Y
F
Y
A
Q
V
E
E
V
L
N
P
S
L
K
G
K
P
V
V
V
C
VF
S
--
G
R
F
E
D
S
G
A
V
A
T
A
N
Y
E
A
R
K
F
G
V
K
A
G
I
P
I
V
E
A
K
K
I
L
P
N
A
V
Y
L
P
-------
M
R
K
E
V
Y
Q
Q
V
S
S
R
I
M
-
N
L
L
R
E
Y
S
E
K
I
E
I
A
S
I
D
E
A
Y
L
D
I
S
D
K
V
-
R
-----
D
-
Y
-
R
E---------------------------------------------------
A
Y
N
L
G
L
E
I
K
N
K
I
L
E
K
E
K
I
T
V
T
V
G
I
S
K
N
K
V
F
A
K
I
A
A
D
M
A
K
P
N
G
I
K
V
I
D
D
E
E
V
K
R
L
I
R
E
L
D
I
A
D
V
P
G
I
G
N
I
T
A
E
-
K
L
K
K
L
G
I
N
K
L
V
D
T
L
S
I
E
F
D
K
L
K
G
M
I
G
E
A
K
-
A
K
Y
-
L
I
S
L
A
R
D
E
Y
N
E
P
I
---
R
T
R
V
R
K
S
I
G
R
I
V
T
M
K
R
N
--
S
R
N
L
E
E
I
----------------------------------------------------------------------------------------------------------------------------------------------------------------------
71
PsiBlast_CBE
54.40
33%
10
- C3 -
2IA6
8
DPO4_SULSO
B:
[2-261]
------
I
V
L
F
V
D
F
D
Y
F
Y
A
Q
V
E
E
V
L
N
P
S
L
K
G
K
P
V
V
V
C
VF
S
--
G
R
F
E
D
S
G
A
V
A
T
A
N
Y
E
A
R
K
F
G
V
K
A
G
I
P
I
V
E
A
K
K
I
L
P
N
A
V
Y
L
P
-------
M
R
K
E
V
Y
Q
Q
V
S
S
R
I
M
-
N
L
L
R
E
Y
S
E
K
I
E
I
A
S
I
D
E
A
Y
L
D
I
S
D
K
V
-
R
-----
D
-
Y
-
R
E---------------------------------------------------
A
Y
N
L
G
L
E
I
K
N
K
I
L
E
K
E
K
I
T
V
T
V
G
I
S
K
N
K
V
F
A
K
I
A
A
D
M
A
K
P
N
G
I
K
V
I
D
D
E
E
V
K
R
L
I
R
E
L
D
I
A
D
V
P
G
I
G
N
I
T
A
E
-
K
L
K
K
L
G
I
N
K
L
V
D
T
L
S
I
E
F
D
K
L
K
G
M
I
G
E
A
K
-
A
K
Y
-
L
I
S
L
A
R
D
E
Y
N
E
P
I
---
R
T
R
V
R
K
S
I
G
R
I
V
T
M
K
R
N
--
S
R
N
L
E
E
I
----------------------------------------------------------------------------------------------------------------------------------------------------------------------
18
PsiBlast_PDB
54.17
33%
13
- C3 -
1RYR
5
DPO4_SULSO
A:
[2-261]
------
I
V
L
F
V
D
F
D
Y
F
Y
A
Q
V
E
E
V
L
N
P
S
L
K
G
K
P
V
V
V
C
V
F
S
--
G
R
F
E
D
S
G
A
V
A
T
A
N
Y
E
A
R
K
F
G
V
K
A
G
I
P
I
V
E
A
K
K
I
L
P
N
A
V
Y
L
P
-------
M
R
K
E
V
Y
Q
Q
V
S
S
R
I
M
-
N
L
L
R
E
Y
S
E
K
I
E
I
A
S
I
D
E
A
Y
L
D
I
S
D
K
V
-
R
-----
D
-
Y
-
R
E
---------------------------------------------------
A
Y
N
L
G
L
E
I
K
N
K
I
L
E
K
E
K
I
T
V
T
V
G
I
S
K
N
K
V
F
A
K
I
A
A
D
M
A
K
P
N
G
I
K
V
I
D
D
E
E
V
K
R
L
I
R
E
L
D
I
A
D
V
P
G
I
G
N
I
T
A
E
-
K
L
K
K
L
G
I
N
K
L
V
D
T
L
S
I
E
F
D
K
L
K
G
M
I
G
E
A
K
-
A
K
Y
-
L
I
S
L
A
R
D
E
Y
N
E
P
I
---
R
T
R
V
R
K
S
I
G
R
I
V
T
M
K
R
N
--
S
R
N
L
E
E
I
----------------------------------------------------------------------------------------------------------------------------------------------------------------------
76
PsiBlast_CBE
54.11
33%
11
- C3 -
2C28
6
DPO4_SULSO
A:
[8-267]
------
I
V
L
F
V
D
F
D
Y
F
Y
A
Q
V
E
E
V
L
N
P
S
L
K
G
K
P
V
V
V
C
VF
S
--
G
R
F
E
D
S
G
A
V
A
T
A
N
Y
E
A
R
K
F
G
V
K
A
G
I
P
I
V
E
A
K
K
I
L
P
N
A
V
Y
L
P
-------
M
R
K
E
V
Y
Q
Q
V
S
S
R
I
M
-
N
L
L
R
E
Y
S
E
K
I
E
I
A
S
I
D
E
A
Y
L
D
I
S
D
K
V
-
R
-----
D
-
Y
-
R
E
---------------------------------------------------
A
Y
N
L
G
L
E
I
K
N
K
I
L
E
K
E
K
I
T
V
T
V
G
I
S
K
N
K
V
F
A
K
I
A
A
D
M
A
K
P
N
G
I
K
V
I
D
D
E
E
V
K
R
L
I
R
E
L
D
I
A
D
V
P
G
I
G
N
I
T
A
E
-
K
L
K
K
L
G
I
N
K
L
V
D
T
L
S
I
E
F
D
K
L
K
G
M
I
G
E
A
K
-
A
K
Y
-
L
I
S
L
A
R
D
E
Y
N
E
P
I
---
R
T
R
V
R
K
S
I
G
R
I
V
T
M
K
R
N
--
S
R
N
L
E
E
I
----------------------------------------------------------------------------------------------------------------------------------------------------------------------
72
PsiBlast_CBE
54.04
33%
11
- C3 -
2IA6
8
DPO4_SULSO
A:
[2-261]
------
I
V
L
F
V
D
F
D
Y
F
Y
A
Q
V
E
E
V
L
N
P
S
L
K
G
K
P
V
V
V
C
VF
S
--
G
R
F
E
D
S
G
A
V
A
T
A
N
Y
E
A
R
K
F
G
V
K
A
G
I
P
I
V
E
A
K
K
I
L
P
N
A
V
Y
L
P
-------
M
R
K
E
V
Y
Q
Q
V
S
S
R
I
M
-
N
L
L
R
E
Y
S
E
K
I
E
I
A
S
I
D
E
A
Y
L
D
I
S
D
K
V
-
R
-----
D
-
Y
-
R
E
---------------------------------------------------
A
Y
N
L
G
L
E
I
K
N
K
I
L
E
K
E
K
I
T
V
T
V
G
I
S
K
N
K
V
F
A
K
I
A
A
D
M
A
K
P
N
G
I
K
V
I
D
D
E
E
V
K
R
L
I
R
E
L
D
I
A
D
V
P
G
I
G
N
I
T
A
E
-
K
L
K
K
L
G
I
N
K
L
V
D
T
L
S
I
E
F
D
K
L
K
G
M
I
G
E
A
K
-
A
K
Y
-
L
I
S
L
A
R
D
E
Y
N
E
P
I
---
R
T
R
V
R
K
S
I
G
R
I
V
T
M
K
R
N
--
S
R
N
L
E
E
I
----------------------------------------------------------------------------------------------------------------------------------------------------------------------
95
PsiBlast_CBE
54.00
33%
11
* C3 *
1RYS
7
DPO4_SULSO
B:
[2-261]
------
I
V
L
F
V
D
F
D
Y
F
Y
A
Q
V
E
E
V
L
N
P
S
L
K
G
K
P
V
V
V
C
VF
S
--
G
R
F
E
D
S
G
A
V
A
T
A
N
Y
E
A
R
K
F
G
V
K
A
G
I
P
I
V
E
A
K
K
I
L
P
N
A
V
Y
L
P
-------
M
R
K
E
V
Y
Q
Q
V
S
S
R
I
M
-
N
L
L
R
E
Y
S
E
K
I
E
I
A
S
I
D
E
A
Y
L
D
I
S
D
K
V
-
R
-----
D
-
Y
-
R
E---------------------------------------------------
A
Y
N
L
G
L
E
I
K
N
K
I
L
E
K
E
K
I
T
V
T
V
G
I
S
K
N
K
V
F
A
K
I
A
A
D
M
A
K
P
N
G
I
K
V
I
D
D
E
E
V
K
R
L
I
R
E
L
D
I
A
D
V
P
G
I
G
N
I
T
A
E
-
K
L
K
K
L
G
I
N
K
L
V
D
T
L
S
I
E
F
D
K
L
K
G
M
I
G
E
A
K
-
A
K
Y
-
L
I
S
L
A
R
D
E
Y
N
E
P
I
---
R
T
R
V
R
K
S
I
G
R
I
V
T
M
K
R
N
--
S
R
N
L
E
E
I
----------------------------------------------------------------------------------------------------------------------------------------------------------------------
93
PsiBlast_CBE
53.94
33%
10
- C3 -
1S0N
6
DPO4_SULSO
A:
[2-261]
------
I
V
L
F
V
D
F
D
Y
F
Y
A
Q
V
E
E
V
L
N
P
S
L
K
G
K
P
V
V
V
C
V
F
S
--
G
R
F
E
D
S
G
A
V
A
T
A
N
Y
E
A
R
K
F
G
V
K
A
G
I
P
I
V
E
A
K
K
I
L
P
N
A
V
Y
L
P
-------
M
R
K
E
V
Y
Q
Q
V
S
S
R
I
M
-
N
L
L
R
E
Y
S
E
K
I
E
I
A
S
I
D
E
A
Y
L
D
I
S
D
K
V
-
R
-----
D
-
Y
-
R
E
---------------------------------------------------
A
Y
N
L
G
L
E
I
K
N
K
I
L
E
K
E
K
I
T
V
T
V
G
I
S
K
N
K
V
F
A
K
I
A
A
D
M
A
K
P
N
G
I
K
V
I
D
D
E
E
V
K
R
L
I
R
E
L
D
I
A
D
V
P
G
I
G
N
I
T
A
E
-
K
L
K
K
L
G
I
N
K
L
V
D
T
L
S
I
E
F
D
K
L
K
G
M
I
G
E
A
K
-
A
K
Y
-
L
I
S
L
A
R
D
E
Y
N
E
P
I
---
R
T
R
V
R
K
S
I
G
R
I
V
T
M
K
R
N
--
S
R
N
L
E
E
I
----------------------------------------------------------------------------------------------------------------------------------------------------------------------
48
PsiBlast_CBE
53.94
33%
12
- C3 -
2W9A
6
DPO4_SULSO
A:
[8-267]
------
I
V
L
F
V
D
F
D
Y
F
Y
A
Q
V
E
E
V
L
N
P
S
L
K
G
K
P
V
V
V
C
VF
S
--
G
R
F
E
D
S
G
A
V
A
T
A
N
Y
E
A
R
K
F
G
V
K
A
G
I
P
I
V
E
A
K
K
I
L
P
N
A
V
Y
L
P
-------
M
R
K
E
V
Y
Q
Q
V
S
S
R
I
M
-
N
L
L
R
E
Y
S
E
K
I
E
I
A
S
I
D
E
A
Y
L
D
I
S
D
K
V
-
R
-----
D
-
Y
-
R
E
---------------------------------------------------
A
Y
N
L
G
L
E
I
K
N
K
I
L
E
K
E
K
I
T
V
T
V
G
I
S
K
N
K
V
F
A
K
I
A
A
D
M
A
K
P
N
G
I
K
V
I
D
D
E
E
V
K
R
L
I
R
E
L
D
I
A
D
V
P
G
I
G
N
I
T
A
E
-
K
L
K
K
L
G
I
N
K
L
V
D
T
L
S
I
E
F
D
K
L
K
G
M
I
G
E
A
K
-
A
K
Y
-
L
I
S
L
A
R
D
E
Y
N
E
P
I
---
R
T
R
V
R
K
S
I
G
R
I
V
T
M
K
R
N
--
S
R
N
L
E
E
I
----------------------------------------------------------------------------------------------------------------------------------------------------------------------
96
PsiBlast_CBE
53.92
33%
6
- C3 -
1N56
7
DPO4_SULSO
B:
[2-261]
------
I
V
L
F
V
D
F
D
Y
F
Y
A
Q
V
E
E
V
L
N
P
S
L
K
G
K
P
V
V
V
C
VF
S
--
G
R
F
E
D
S
G
A
V
A
T
A
N
Y
E
A
R
K
F
G
V
K
A
G
I
P
I
V
E
A
K
K
I
L
P
N
A
V
Y
L
P
-------
M
R
K
E
V
Y
Q
Q
V
S
S
R
I
M
-
N
L
L
R
E
Y
S
E
K
I
E
I
A
S
I
D
E
A
Y
L
D
I
S
D
K
V
-
R
-----
D
-
Y
-
R
E---------------------------------------------------
A
Y
N
L
G
L
E
I
K
N
K
I
L
E
K
E
K
I
T
V
T
V
G
I
S
K
N
K
V
F
A
K
I
A
A
D
M
A
K
P
N
G
I
K
V
I
D
D
E
E
V
K
R
L
I
R
E
L
D
I
A
D
V
P
G
I
G
N
I
T
A
E
-
K
L
K
K
L
G
I
N
K
L
V
D
T
L
S
I
E
F
D
K
L
K
G
M
I
G
E
A
K
-
A
K
Y
-
L
I
S
L
A
R
D
E
Y
N
E
P
I
---
R
T
R
V
R
K
S
I
G
R
I
V
T
M
K
R
N
--
S
R
N
L
E
E
I
----------------------------------------------------------------------------------------------------------------------------------------------------------------------
17
PsiBlast_PDB
53.85
33%
8
- C3 -
1N56
5
DPO4_SULSO
A:
[2-261]
------
I
V
L
F
V
D
F
D
Y
F
Y
A
Q
V
E
E
V
L
N
P
S
L
K
G
K
P
V
V
V
C
VF
S
--
G
R
F
E
D
S
G
A
V
A
T
A
N
Y
E
A
R
K
F
G
V
K
A
G
I
P
I
V
E
A
K
K
I
L
P
N
A
V
Y
L
P
-------
M
R
K
E
V
Y
Q
Q
V
S
S
R
I
M
-
N
L
L
R
E
Y
S
E
K
I
E
I
A
S
I
D
E
A
Y
L
D
I
S
D
K
V
-
R
-----
D
-
Y
-
R
E
---------------------------------------------------
A
Y
N
L
G
L
E
I
K
N
K
I
L
E
K
E
K
I
T
V
T
V
G
I
S
K
N
K
V
F
A
K
I
A
A
D
M
A
K
P
N
G
I
K
V
I
D
D
E
E
V
K
R
L
I
R
E
L
D
I
A
D
V
P
G
I
G
N
I
T
A
E
-
K
L
K
K
L
G
I
N
K
L
V
D
T
L
S
I
E
F
D
K
L
K
G
M
I
G
E
A
K
-
A
K
Y
-
L
I
S
L
A
R
D
E
Y
N
E
P
I
---
R
T
R
V
R
K
S
I
G
R
I
V
T
M
K
R
N
--
S
R
N
L
E
E
I
----------------------------------------------------------------------------------------------------------------------------------------------------------------------
61
PsiBlast_CBE
53.76
33%
12
- C3 -
2R8H
6
DPO4_SULSO
A:
[2-261]
------
I
V
L
F
V
D
F
D
Y
F
Y
A
Q
V
E
E
V
L
N
P
S
L
K
G
K
P
V
V
V
C
V
F
S
--
G
R
F
E
D
S
G
A
V
A
T
A
N
Y
E
A
R
K
F
G
V
K
A
G
I
P
I
V
E
A
K
K
I
L
P
N
A
V
Y
L
P
-------
M
R
K
E
V
Y
Q
Q
V
S
S
R
I
M
-
N
L
L
R
E
Y
S
E
K
I
E
I
A
S
I
D
E
A
Y
L
D
I
S
D
K
V
-
R
-----
D
-
Y
-
R
E
---------------------------------------------------
A
Y
N
L
G
L
E
I
K
N
K
I
L
E
K
E
K
I
T
V
T
V
G
I
S
K
N
K
V
F
A
K
I
A
A
D
M
A
K
P
N
G
I
K
V
I
D
D
E
E
V
K
R
L
I
R
E
L
D
I
A
D
V
P
G
I
G
N
I
T
A
E
-
K
L
K
K
L
G
I
N
K
L
V
D
T
L
S
I
E
F
D
K
L
K
G
M
I
G
E
A
K
-
A
K
Y
-
L
I
S
L
A
R
D
E
Y
N
E
P
I
---
R
T
R
V
R
K
S
I
G
R
I
V
T
M
K
R
N
--
S
R
N
L
E
E
I
----------------------------------------------------------------------------------------------------------------------------------------------------------------------
46
PsiBlast_CBE
53.73
33%
4
- C3 -
2W9C
6
DPO4_SULSO
B:
[8-267]
------
I
V
L
F
V
D
F
D
Y
F
Y
A
Q
V
E
E
V
L
N
P
S
L
K
G
K
P
V
V
V
C
VF
S
--
G
R
F
E
D
S
G
A
V
A
T
A
N
Y
E
A
R
K
F
G
V
K
A
G
I
P
I
V
E
A
K
K
I
L
P
N
A
V
Y
L
P
-------
M
R
K
E
V
Y
Q
Q
V
S
S
R
I
M
-
N
L
L
R
E
Y
S
E
K
I
E
I
A
S
I
D
E
A
Y
L
D
I
S
D
K
V
-
R
-----
D
-
Y
-
R
E---------------------------------------------------
A
Y
N
L
G
L
E
I
K
N
K
I
L
E
K
E
K
I
T
V
T
V
G
I
S
K
N
K
V
F
A
K
I
A
A
D
M
A
K
P
N
G
I
K
V
I
D
D
E
E
V
K
R
L
I
R
E
L
D
I
A
D
V
P
G
I
G
N
I
T
A
E
-
K
L
K
K
L
G
I
N
K
L
V
D
T
L
S
I
E
F
D
K
L
K
G
M
I
G
E
A
K
-
A
K
Y
-
L
I
S
L
A
R
D
E
Y
N
E
P
I
---
R
T
R
V
R
K
S
I
G
R
I
V
T
M
K
R
N
--
S
R
N
L
E
E
I
----------------------------------------------------------------------------------------------------------------------------------------------------------------------
54
PsiBlast_CBE
53.11
33%
9
- C3 -
2V9W
6
DPO4_SULSO
B:
[8-267]
------
I
V
L
F
V
D
F
D
Y
F
Y
A
Q
V
E
E
V
L
N
P
S
L
K
G
K
P
V
V
V
C
VF
S
--
G
R
F
E
D
S
G
A
V
A
T
A
N
Y
E
A
R
K
F
G
V
K
A
G
I
P
I
V
E
A
K
K
I
L
P
N
A
V
Y
L
P
-------
M
R
K
E
V
Y
Q
Q
V
S
S
R
I
M
-
N
L
L
R
E
Y
S
E
K
I
E
I
A
S
I
D
E
A
Y
L
D
I
S
D
K
V
-
R
-----
D
-
Y
-
R
E---------------------------------------------------
A
Y
N
L
G
L
E
I
K
N
K
I
L
E
K
E
K
I
T
V
T
V
G
I
S
K
N
K
V
F
A
K
I
A
A
D
M
A
K
P
N
G
I
K
V
I
D
D
E
E
V
K
R
L
I
R
E
L
D
I
A
D
V
P
G
I
G
N
I
T
A
E
-
K
L
K
K
L
G
I
N
K
L
V
D
T
L
S
I
E
F
D
K
L
K
G
M
I
G
E
A
K
-
A
K
Y
-
L
I
S
L
A
R
D
E
Y
N
E
P
I
---
R
T
R
V
R
K
S
I
G
R
I
V
T
M
K
R
N
--
S
R
N
L
E
E
I
----------------------------------------------------------------------------------------------------------------------------------------------------------------------
103
Fugue
51.21
37%
-6
- C3 -
1JX4
5
DPO4_SULSO
A:
[2-204]
------
I
V
L
F
V
D
F
D
Y
F
Y
A
Q
V
E
E
V
L
N
P
S
L
K
G
K
P
V
V
V
C
--
V
FS
G
R
F
E
D
S
G
A
V
A
T
A
N
Y
E
A
R
K
F
G
V
K
A
G
I
P
I
V
E
A
K
K
I
L
P
N
A
V
Y
L
P
-------
M
R
K
E
V
Y
Q
Q
V
S
S
R
I
-
M
N
L
L
R
E
Y
S
E
K
I
E
I
A
S
I
D
E
A
Y
L
D
I
S
D
K
V
R
D
-----
Y
-
R
-
E
----------------------------------------------------
A
Y
N
L
G
L
E
I
K
N
K
I
L
E
K
E
K
I
T
V
T
V
G
I
S
K
N
K
V
F
A
K
I
A
A
D
M
A
K
P
N
G
I
K
V
I
D
D
E
E
V
K
R
L
I
R
E
L
D
I
A
D
V
P
G
I
G
N
I
T
A
E
-
K
L
K
K
L
G
I
N
K
L
V
D
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
47
PsiBlast_CBE
50.86
33%
9
- C3 -
2W9B
4
DPO4_SULSO
B:
[8-267]
------
I
V
L
F
V
D
F
D
Y
F
Y
A
Q
V
E
E
V
L
N
P
S
L
K
G
K
P
V
V
V
C
V
F
S
--
G
R
F
E
D
S
G
A
V
A
T
A
N
Y
E
A
R
K
F
G
V
K
A
G
I
P
I
V
E
A
K
K
I
L
P
N
A
V
Y
L
P
-------
M
R
K
E
V
Y
Q
Q
V
S
S
R
I
M
-
N
L
L
R
E
Y
S
E
K
I
E
I
A
S
I
D
E
A
Y
L
D
I
S
D
K
V
-
R
-----
D
-
Y
-
R
E
---------------------------------------------------
A
Y
N
L
G
L
E
I
K
N
K
I
L
E
K
E
K
I
T
V
T
V
G
I
S
K
N
K
V
F
A
K
I
A
A
D
M
A
K
P
N
G
I
K
V
I
D
D
E
E
V
K
R
L
I
R
E
L
D
I
A
D
V
P
G
I
G
N
I
T
A
E
-
K
L
K
K
L
G
I
N
K
L
V
D
T
L
S
I
E
F
D
K
L
K
G
M
I
G
E
A
K
-
A
K
Y
-
L
I
S
L
A
R
D
E
Y
N
E
P
I
---
R
T
R
V
R
K
S
I
G
R
I
V
T
M
K
R
N
--
S
R
N
L
E
E
I
----------------------------------------------------------------------------------------------------------------------------------------------------------------------