@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : bsu23960: (2016-07-07 )
MIKVEKLSKSFGKHEVLKNISTTIAEGEVVAVIGPSGSGKSTFLRCLNLLEKPNGGTITIKDTEITKPKTNTLKVRENIGMVFQHFHLFPHKTVLENIMYAPVNVKKESKQAAQEKAEDLLRKVGLFEKRNDYPNRLSGGQKQRVAIARALAMNPDIMLFDEPTSALDPEMVKEVLQVMKELVETGMTMVIVTHEMGFAKEVADRVLFMDQGMIVEDGNPKEFFMSPKSKRAQDFLEKIL
Atome Classification :
(34 SA)
.........10....----....20........30........40........50........60---------.--------......--..70....-..-..80....--....90........100.......110.......120--.......-130..-.......140.......150.......160.......170.......-180-..-.....190.......200.......210.......220.......230.......240
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MI
K
V
E
K
L
S
K
S
F
G
K
H
E
----
V
L
K
N
I
S
T
TIAEG
E
V
V
A
V
IGPSGS
G
K
S
T
F
L
R
C
L
N
L
LEKPNG
G
T
I
T
I
----------K--------DTEITK--PKT
N
T
L
K
V
-
R
E
-
N
I
G
M
V
F
Q
H
--
F
HLF
P
H
K
T
V
L
E
N
I
MYAPVNV
K
K
E
S
K
Q
A
A
Q
E
K
A
E
D
L
L
R
--KVGL
F
E
K-R--ND-YPNRLSGG
Q
K
Q
R
V
A
I
A
R
A
LAMNP
D
I
M
L
FDEPTSAL
D
P
E
M
V
K
E
V
L
Q
V
M
-
K
E
L
-
V
E-TG
M
T
M
V
I
V
THEMG
F
A
K
E
V
A
D
R
V
L
F
MDQ
G
M
I
VEDG
N
P
K
E
F
FMSP
K
S
K
R
A
Q
D
F
L
E
K
IL
3
PsiBlast_PDB
93.30
62%
-120
- C1 -
4YMU
2
?
J:
[1-240]
M
I
F
V
N
D
V
Y
K
N
F
G
S
L
E
----
V
L
K
G
V
T
L
K
V
N
K
G
E
V
V
V
I
I
G
P
S
G
S
G
K
S
T
L
L
R
C
I
N
L
L
E
E
P
T
K
G
E
V
F
I
----------
D
--------
G
V
K
I
N
N
--
G
K
V
N
I
N
K
V
-
R
Q
-
K
V
G
M
V
F
Q
H
--
F
N
L
F
P
H
L
T
A
I
E
N
I
T
L
A
P
V
K
V
K
K
M
N
K
K
E
A
E
E
L
A
V
D
L
L
A
--
K
V
G
L
L
D
K
-
K
--
D
Q
-
Y
P
I
K
L
S
G
G
Q
K
Q
R
L
A
I
A
R
A
L
A
M
Q
P
E
V
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
K
E
V
L
N
V
M
-
K
Q
L
-
A
N
-
E
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
I
F
M
D
D
G
V
I
V
E
E
G
T
P
E
E
I
F
Y
R
A
K
N
E
R
T
R
E
F
L
S
K
I
L
29
PsiBlast_CBE
93.19
63%
-122
- C1 -
2OLK
1
?
D:
[24-263]
M
I
D
V
H
Q
L
K
K
S
F
G
S
L
E
----
V
L
K
G
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
E
D
F
D
E
G
E
I
I
I
----------
D
--------
G
I
N
L
K
A
--
K
D
T
N
L
N
K
V
-
R
E
-
E
V
G
M
V
F
Q
R
--
F
N
L
F
P
H
M
T
V
L
N
N
I
T
L
A
P
M
K
V
R
K
W
P
R
E
K
A
E
A
K
A
M
E
L
L
D
--
K
V
G
L
K
D
K
-
A
--
H
A
-
Y
P
D
S
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
S
V
M
-
K
Q
L
-
A
N
-
E
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
L
F
M
D
G
G
Y
I
I
E
E
G
K
P
E
D
L
F
D
R
P
Q
H
E
R
T
K
A
F
L
S
K
V
F
9
PsiBlast_PDB
93.15
63%
-123
- C1 -
2OUK
1
?
A:
[24-263]
M
I
D
V
H
Q
L
K
K
S
F
G
S
L
E
----
V
L
K
G
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
E
D
F
D
E
G
E
I
I
I
----------
D
--------
G
I
N
L
K
A
--
K
D
T
N
L
N
K
V
-
R
E
-
E
V
G
M
V
F
Q
R
--
F
N
L
F
P
H
M
T
V
L
N
N
I
T
L
A
P
M
K
V
R
K
W
P
R
E
K
A
E
A
K
A
M
E
L
L
D
--
K
V
G
L
K
D
K
-
A
--
H
A
-
Y
P
D
S
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
S
V
M
-
K
Q
L
-
A
N
-
E
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
L
F
M
D
G
G
Y
I
I
E
E
G
K
P
E
D
L
F
D
R
P
Q
H
E
R
T
K
A
F
L
S
K
V
F
22
PsiBlast_CBE
92.11
62%
-124
- C1 -
4YMU
2
?
A:
[1-240]
M
I
F
V
N
D
V
Y
K
N
F
G
S
L
E
----
V
L
K
G
V
T
L
K
V
N
K
G
E
V
V
V
I
I
G
P
S
G
S
G
K
S
T
L
L
R
C
I
N
L
L
E
E
P
T
K
G
E
V
F
I
----------
D
--------
G
V
K
I
N
N
--
G
K
V
N
I
N
K
V
-
R
Q
-
K
V
G
M
V
F
Q
H
--
F
N
L
F
P
H
L
T
A
I
E
N
I
T
L
A
P
V
K
V
K
K
M
N
K
K
E
A
E
E
L
A
V
D
L
L
A
--
K
V
G
L
L
D
K
-
K
--
D
Q
-
Y
P
I
K
L
S
G
G
Q
K
Q
R
L
A
I
A
R
A
L
A
M
Q
P
E
V
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
K
E
V
L
N
V
M
-
K
Q
L
-
A
N
-
E
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
I
F
M
D
D
G
V
I
V
E
E
G
T
P
E
E
I
F
Y
R
A
K
N
E
R
T
R
E
F
L
S
K
I
L
7
PsiBlast_PDB
91.92
63%
-129
- C1 -
2OLJ
4
?
A:
[24-263]
M
I
D
V
H
Q
L
K
K
S
F
G
S
L
E
----
V
L
K
G
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
E
D
F
D
E
G
E
I
I
I
----------
D
--------
G
I
N
L
K
A
--
K
D
T
N
L
N
K
V
-
R
E
-
E
V
G
M
V
F
Q
R
--
F
N
L
F
P
H
M
T
V
L
N
N
I
T
L
A
P
M
K
V
R
K
W
P
R
E
K
A
E
A
K
A
M
E
L
L
D
--
K
V
G
L
K
D
K
-
A
--
H
A
-
Y
P
D
S
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
S
V
M
-
K
Q
L
-
A
N
-
E
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
L
F
M
D
G
G
Y
I
I
E
E
G
K
P
E
D
L
F
D
R
P
Q
H
E
R
T
K
A
F
L
S
K
V
F
21
PsiBlast_CBE
91.83
62%
-120
- C1 -
4YMV
1
?
A:
[1-240]
M
I
F
V
N
D
V
Y
K
N
F
G
S
L
E
----
V
L
K
G
V
T
L
K
V
N
K
G
E
V
V
V
I
I
G
P
S
G
S
G
K
S
T
L
L
R
C
I
N
L
L
E
E
P
T
K
G
E
V
F
I
----------
D
--------
G
V
K
I
N
N
--
G
K
V
N
I
N
K
V
-
R
Q
-
K
V
G
M
V
F
Q
H
--
F
N
L
F
P
H
L
T
A
I
E
N
I
T
L
A
P
V
K
V
K
K
M
N
K
K
E
A
E
E
L
A
V
D
L
L
A
--
K
V
G
L
L
D
K
-
K
--
D
Q
-
Y
P
I
K
L
S
G
G
Q
K
Q
R
L
A
I
A
R
A
L
A
M
Q
P
E
V
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
K
E
V
L
N
V
M
-
K
Q
L
-
A
N
-
E
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
I
F
M
D
D
G
V
I
V
E
E
G
T
P
E
E
I
F
Y
R
A
K
N
E
R
T
R
E
F
L
S
K
I
L
23
PsiBlast_CBE
91.79
63%
-119
- C1 -
3C41
3
?
K:
[3-242]
M
I
D
V
H
Q
L
K
K
S
F
G
S
L
E
----
V
L
K
G
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
E
D
F
D
E
G
E
I
I
I
----------
D
--------
G
I
N
L
K
A
--
K
D
T
N
L
N
K
V
-
R
E
-
E
V
G
M
V
F
Q
R
--
F
N
L
F
P
H
M
T
V
L
N
N
I
T
L
A
P
M
K
V
R
K
W
P
R
E
K
A
E
A
K
A
M
E
L
L
D
--
K
V
G
L
K
D
K
-
A
--
H
A
-
Y
P
D
S
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
S
V
M
-
K
Q
L
-
A
N
-
E
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
L
F
M
D
G
G
Y
I
I
E
E
G
K
P
E
D
L
F
D
R
P
Q
H
E
R
T
K
A
F
L
S
K
V
F
5
PsiBlast_PDB
91.28
62%
-117
- C1 -
4YMW
-
?
J:
[1-240]
M
I
F
V
N
D
V
Y
K
N
F
G
S
L
E
----
V
L
K
G
V
T
L
K
V
N
K
G
E
V
V
V
I
I
G
P
S
G
S
G
K
S
T
L
L
R
C
I
N
L
L
E
E
P
T
K
G
E
V
F
I
----------
D
--------
G
V
K
I
N
N
--
G
K
V
N
I
N
K
V
-
R
Q
-
K
V
G
M
V
F
Q
H
--
F
N
L
F
P
H
L
T
A
I
E
N
I
T
L
A
P
V
K
V
K
K
M
N
K
K
E
A
E
E
L
A
V
D
L
L
A
--
K
V
G
L
L
D
K
-
K
--
D
Q
-
Y
P
I
K
L
S
G
G
Q
K
Q
R
L
A
I
A
R
A
L
A
M
Q
P
E
V
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
K
E
V
L
N
V
M
-
K
Q
L
-
A
N
-
E
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
I
F
M
D
D
G
V
I
V
E
E
G
T
P
E
E
I
F
Y
R
A
K
N
E
R
T
R
E
F
L
S
K
I
L
6
PsiBlast_PDB
90.69
63%
-112
- C1 -
3C41
3
?
J:
[3-242]
M
I
D
V
H
Q
L
K
K
S
F
G
S
L
E
----
V
L
K
G
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
E
D
F
D
E
G
E
I
I
I
----------
D
--------
G
I
N
L
K
A
--
K
D
T
N
L
N
K
V
-
R
E
-
E
V
G
M
V
F
Q
R
--
F
N
L
F
P
H
M
T
V
L
N
N
I
T
L
A
P
M
K
V
R
K
W
P
R
E
K
A
E
A
K
A
M
E
L
L
D
--
K
V
G
L
K
D
K
-
A
--
H
A
-
Y
P
D
S
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
S
V
M
-
K
Q
L
-
A
N
-
E
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
L
F
M
D
G
G
Y
I
I
E
E
G
K
P
E
D
L
F
D
R
P
Q
H
E
R
T
K
A
F
L
S
K
V
F
10
PsiBlast_PDB
90.39
63%
-119
- C1 -
2Q0H
4
?
A:
[24-263]
M
I
D
V
H
Q
L
K
K
S
F
G
S
L
E
----
V
L
K
G
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
E
D
F
D
E
G
E
I
I
I
----------
D
--------
G
I
N
L
K
A
--
K
D
T
N
L
N
K
V
-
R
E
-
E
V
G
M
V
F
Q
R
--
F
N
L
F
P
H
M
T
V
L
N
N
I
T
L
A
P
M
K
V
R
K
W
P
R
E
K
A
E
A
K
A
M
E
L
L
D
--
K
V
G
L
K
D
K
-
A
--
H
A
-
Y
P
D
S
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
S
V
M
-
K
Q
L
-
A
N
-
E
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
L
F
M
D
G
G
Y
I
I
E
E
G
K
P
E
D
L
F
D
R
P
Q
H
E
R
T
K
A
F
L
S
K
V
F
122
HHSearch
90.22
62%
-117
- C1 -
4YMU
2
?
J:
[1-237]
M
I
F
V
N
D
V
Y
K
N
F
G
S
L
E
----
V
L
K
G
V
T
L
K
V
N
K
G
E
V
V
V
I
I
G
P
S
G
S
G
K
S
T
L
L
R
C
I
N
L
L
E
E
P
T
K
G
E
V
F
I
----------
D
--------
G
V
K
I
N
N
--
G
K
V
N
I
N
K
V
-
R
Q
-
K
V
G
M
V
F
Q
H
--
F
N
L
F
P
H
L
T
A
I
E
N
I
T
L
A
P
V
K
V
K
K
M
N
K
K
E
A
E
E
L
A
V
D
L
L
A
--
K
V
G
L
L
D
K
-
K
--
D
Q
-
Y
P
I
K
L
S
G
G
Q
K
Q
R
L
A
I
A
R
A
L
A
M
Q
P
E
V
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
K
E
V
L
N
V
M
-
K
Q
L
-
A
N
-
E
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
I
F
M
D
D
G
V
I
V
E
E
G
T
P
E
E
I
F
Y
R
A
K
N
E
R
T
R
E
F
L
S
---
1
PsiBlast_PDB
89.90
62%
-120
- C1 -
4YMS
-
?
J:
[1-240]
M
I
F
V
N
D
V
Y
K
N
F
G
S
L
E
----
V
L
K
G
V
T
L
K
V
N
K
G
E
V
V
V
I
I
G
P
S
G
S
G
K
S
T
L
L
R
C
I
N
L
L
E
E
P
T
K
G
E
V
F
I
----------
D
--------
G
V
K
I
N
N
--
G
K
V
N
I
N
K
V
-
R
Q
-
K
V
G
M
V
F
Q
H
--
F
N
L
F
P
H
L
T
A
I
E
N
I
T
L
A
P
V
K
V
K
K
M
N
K
K
E
A
E
E
L
A
V
D
L
L
A
--
K
V
G
L
L
D
K
-
K
--
D
Q
-
Y
P
I
K
L
S
G
G
Q
K
Q
R
L
A
I
A
R
A
L
A
M
Q
P
E
V
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
K
E
V
L
N
V
M
-
K
Q
L
-
A
N
-
E
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
I
F
M
D
D
G
V
I
V
E
E
G
T
P
E
E
I
F
Y
R
A
K
N
E
R
T
R
E
F
L
S
K
I
L
4
PsiBlast_PDB
89.82
62%
-121
- C1 -
4YMV
1
?
J:
[1-240]
M
I
F
V
N
D
V
Y
K
N
F
G
S
L
E
----
V
L
K
G
V
T
L
K
V
N
K
G
E
V
V
V
I
I
G
P
S
G
S
G
K
S
T
L
L
R
C
I
N
L
L
E
E
P
T
K
G
E
V
F
I
----------
D
--------
G
V
K
I
N
N
--
G
K
V
N
I
N
K
V
-
R
Q
-
K
V
G
M
V
F
Q
H
--
F
N
L
F
P
H
L
T
A
I
E
N
I
T
L
A
P
V
K
V
K
K
M
N
K
K
E
A
E
E
L
A
V
D
L
L
A
--
K
V
G
L
L
D
K
-
K
--
D
Q
-
Y
P
I
K
L
S
G
G
Q
K
Q
R
L
A
I
A
R
A
L
A
M
Q
P
E
V
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
K
E
V
L
N
V
M
-
K
Q
L
-
A
N
-
E
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
I
F
M
D
D
G
V
I
V
E
E
G
T
P
E
E
I
F
Y
R
A
K
N
E
R
T
R
E
F
L
S
K
I
L
2
PsiBlast_PDB
89.78
62%
-119
- C1 -
4YMT
-
?
J:
[1-240]
M
I
F
V
N
D
V
Y
K
N
F
G
S
L
E
----
V
L
K
G
V
T
L
K
V
N
K
G
E
V
V
V
I
I
G
P
S
G
S
G
K
S
T
L
L
R
C
I
N
L
L
E
E
P
T
K
G
E
V
F
I
----------
D
--------
G
V
K
I
N
N
--
G
K
V
N
I
N
K
V
-
R
Q
-
K
V
G
M
V
F
Q
H
--
F
N
L
F
P
H
L
T
A
I
E
N
I
T
L
A
P
V
K
V
K
K
M
N
K
K
E
A
E
E
L
A
V
D
L
L
A
--
K
V
G
L
L
D
K
-
K
--
D
Q
-
Y
P
I
K
L
S
G
G
Q
K
Q
R
L
A
I
A
R
A
L
A
M
Q
P
E
V
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
K
E
V
L
N
V
M
-
K
Q
L
-
A
N
-
E
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
I
F
M
D
D
G
V
I
V
E
E
G
T
P
E
E
I
F
Y
R
A
K
N
E
R
T
R
E
F
L
S
K
I
L
121
HHSearch
89.75
64%
-127
- C1 -
2OLJ
4
?
A:
[24-260]
M
I
D
V
H
Q
L
K
K
S
F
G
S
L
E
----
V
L
K
G
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
E
D
F
D
E
G
E
I
I
I
----------
D
--------
G
I
N
L
K
A
--
K
D
T
N
L
N
K
V
-
R
E
-
E
V
G
M
V
F
Q
R
--
F
N
L
F
P
H
M
T
V
L
N
N
I
T
L
A
P
M
K
V
R
K
W
P
R
E
K
A
E
A
K
A
M
E
L
L
D
--
K
V
G
L
K
D
K
-
A
--
H
A
-
Y
P
D
S
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
S
V
M
-
K
Q
L
-
A
N
-
E
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
L
F
M
D
G
G
Y
I
I
E
E
G
K
P
E
D
L
F
D
R
P
Q
H
E
R
T
K
A
F
L
S
---
24
PsiBlast_CBE
89.58
63%
-123
- C1 -
3C4J
4
?
B:
[24-263]
M
I
D
V
H
Q
L
K
K
S
F
G
S
L
E
----
V
L
K
G
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
E
D
F
D
E
G
E
I
I
I
----------
D
--------
G
I
N
L
K
A
--
K
D
T
N
L
N
K
V
-
R
E
-
E
V
G
M
V
F
Q
R
--
F
N
L
F
P
H
M
T
V
L
N
N
I
T
L
A
P
M
K
V
R
K
W
P
R
E
K
A
E
A
K
A
M
E
L
L
D
--
K
V
G
L
K
D
K
-
A
--
H
A
-
Y
P
D
S
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
S
V
M
-
K
Q
L
-
A
N
-
E
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
L
F
M
D
G
G
Y
I
I
E
E
G
K
P
E
D
L
F
D
R
P
Q
H
E
R
T
K
A
F
L
S
K
V
F
27
PsiBlast_CBE
89.49
63%
-122
- C1 -
2OUK
1
?
C:
[24-263]
M
I
D
V
H
Q
L
K
K
S
F
G
S
L
E
----
V
L
K
G
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
E
D
F
D
E
G
E
I
I
I
----------
D
--------
G
I
N
L
K
A
--
K
D
T
N
L
N
K
V
-
R
E
-
E
V
G
M
V
F
Q
R
--
F
N
L
F
P
H
M
T
V
L
N
N
I
T
L
A
P
M
K
V
R
K
W
P
R
E
K
A
E
A
K
A
M
E
L
L
D
--
K
V
G
L
K
D
K
-
A
--
H
A
-
Y
P
D
S
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
S
V
M
-
K
Q
L
-
A
N
-
E
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
L
F
M
D
G
G
Y
I
I
E
E
G
K
P
E
D
L
F
D
R
P
Q
H
E
R
T
K
A
F
L
S
K
V
F
31
PsiBlast_CBE
89.40
63%
-120
- C1 -
2OLK
2
?
B:
[24-263]
M
I
D
V
H
Q
L
K
K
S
F
G
S
L
E
----
V
L
K
G
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
E
D
F
D
E
G
E
I
I
I
----------
D
--------
G
I
N
L
K
A
--
K
D
T
N
L
N
K
V
-
R
E
-
E
V
G
M
V
F
Q
R
--
F
N
L
F
P
H
M
T
V
L
N
N
I
T
L
A
P
M
K
V
R
K
W
P
R
E
K
A
E
A
K
A
M
E
L
L
D
--
K
V
G
L
K
D
K
-
A
--
H
A
-
Y
P
D
S
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
S
V
M
-
K
Q
L
-
A
N
-
E
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
L
F
M
D
G
G
Y
I
I
E
E
G
K
P
E
D
L
F
D
R
P
Q
H
E
R
T
K
A
F
L
S
K
V
F
11
PsiBlast_PDB
89.34
63%
-119
- C1 -
3C4J
3
?
A:
[24-263]
M
I
D
V
H
Q
L
K
K
S
F
G
S
L
E
----
V
L
K
G
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
E
D
F
D
E
G
E
I
I
I
----------
D
--------
G
I
N
L
K
A
--
K
D
T
N
L
N
K
V
-
R
E
-
E
V
G
M
V
F
Q
R
--
F
N
L
F
P
H
M
T
V
L
N
N
I
T
L
A
P
M
K
V
R
K
W
P
R
E
K
A
E
A
K
A
M
E
L
L
D
--
K
V
G
L
K
D
K
-
A
--
H
A
-
Y
P
D
S
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
S
V
M
-
K
Q
L
-
A
N
-
E
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
L
F
M
D
G
G
Y
I
I
E
E
G
K
P
E
D
L
F
D
R
P
Q
H
E
R
T
K
A
F
L
S
K
V
F
30
PsiBlast_CBE
89.16
63%
-120
- C1 -
2OLK
1
?
C:
[24-263]
M
I
D
V
H
Q
L
K
K
S
F
G
S
L
E
----
V
L
K
G
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
E
D
F
D
E
G
E
I
I
I
----------
D
--------
G
I
N
L
K
A
--
K
D
T
N
L
N
K
V
-
R
E
-
E
V
G
M
V
F
Q
R
--
F
N
L
F
P
H
M
T
V
L
N
N
I
T
L
A
P
M
K
V
R
K
W
P
R
E
K
A
E
A
K
A
M
E
L
L
D
--
K
V
G
L
K
D
K
-
A
--
H
A
-
Y
P
D
S
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
S
V
M
-
K
Q
L
-
A
N
-
E
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
L
F
M
D
G
G
Y
I
I
E
E
G
K
P
E
D
L
F
D
R
P
Q
H
E
R
T
K
A
F
L
S
K
V
F
25
PsiBlast_CBE
89.01
63%
-125
- C1 -
2Q0H
4
?
B:
[24-263]
M
I
D
V
H
Q
L
K
K
S
F
G
S
L
E
----
V
L
K
G
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
E
D
F
D
E
G
E
I
I
I
----------
D
--------
G
I
N
L
K
A
--
K
D
T
N
L
N
K
V
-
R
E
-
E
V
G
M
V
F
Q
R
--
F
N
L
F
P
H
M
T
V
L
N
N
I
T
L
A
P
M
K
V
R
K
W
P
R
E
K
A
E
A
K
A
M
E
L
L
D
--
K
V
G
L
K
D
K
-
A
--
H
A
-
Y
P
D
S
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
S
V
M
-
K
Q
L
-
A
N
-
E
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
L
F
M
D
G
G
Y
I
I
E
E
G
K
P
E
D
L
F
D
R
P
Q
H
E
R
T
K
A
F
L
S
K
V
F
32
PsiBlast_CBE
89.00
63%
-116
- C1 -
2OLJ
3
?
B:
[24-263]
M
I
D
V
H
Q
L
K
K
S
F
G
S
L
E
----
V
L
K
G
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
E
D
F
D
E
G
E
I
I
I
----------
D
--------
G
I
N
L
K
A
--
K
D
T
N
L
N
K
V
-
R
E
-
E
V
G
M
V
F
Q
R
--
F
N
L
F
P
H
M
T
V
L
N
N
I
T
L
A
P
M
K
V
R
K
W
P
R
E
K
A
E
A
K
A
M
E
L
L
D
--
K
V
G
L
K
D
K
-
A
--
H
A
-
Y
P
D
S
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
S
V
M
-
K
Q
L
-
A
N
-
E
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
L
F
M
D
G
G
Y
I
I
E
E
G
K
P
E
D
L
F
D
R
P
Q
H
E
R
T
K
A
F
L
S
K
V
F
12
PsiBlast_PDB
86.39
55%
-108
- C1 -
4U00
3
?
A:
[4-242]
I
I
R
I
R
N
L
H
K
W
F
G
P
L
H
----
V
L
K
G
I
H
L
E
V
A
P
G
E
K
L
V
I
I
G
P
S
G
S
G
K
S
T
L
I
R
T
I
N
R
L
E
D
F
Q
E
G
E
V
V
V
-------------------
D
G
L
S
V
K
--
D
D
R
A
L
R
E
I
-
R
R
-
E
V
G
M
V
F
Q
Q
--
F
N
L
F
P
H
M
T
V
L
E
N
V
T
L
A
P
M
R
V
R
R
W
P
R
E
K
A
E
K
K
A
L
E
L
L
E
--
R
V
G
I
L
D
Q
-
A
--
R
K
-
Y
P
A
Q
L
S
G
G
Q
Q
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
D
V
M
-
R
D
L
-
A
Q
-
G
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
A
D
R
V
V
F
M
D
G
G
Q
I
V
E
E
G
R
P
E
E
I
F
T
R
P
K
E
E
R
T
R
S
F
L
Q
R
V
L
8
PsiBlast_PDB
85.70
63%
-122
- C1 -
2OLK
1
?
A:
[24-263]
M
I
D
V
H
Q
L
K
K
S
F
G
S
L
E
----
V
L
K
G
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
E
D
F
D
E
G
E
I
I
I
----------
D
--------
G
I
N
L
K
A
--
K
D
T
N
L
N
K
V
-
R
E
-
E
V
G
M
V
F
Q
R
--
F
N
L
F
P
H
M
T
V
L
N
N
I
T
L
A
P
M
K
V
R
K
W
P
R
E
K
A
E
A
K
A
M
E
L
L
D
--
K
V
G
L
K
D
K
-
A
--
H
A
-
Y
P
D
S
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
S
V
M
-
K
Q
L
-
A
N
-
E
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
L
F
M
D
G
G
Y
I
I
E
E
G
K
P
E
D
L
F
D
R
P
Q
H
E
R
T
K
A
F
L
S
K
V
F
14
PsiBlast_PDB
75.93
52%
-1
- C1 -
1B0U
4
HISP_SALTY
A:
[7-257]
-
L
H
V
I
D
L
H
K
R
Y
G
G
H
E
----
V
L
K
G
V
S
L
Q
A
R
A
G
D
V
I
S
I
I
G
S
S
G
S
G
K
S
T
F
L
R
C
I
N
F
L
E
K
P
S
E
G
A
I
I
V
NGQNI
N
L
V
R
D
K
--------
D
G
Q
L
K
V
--
A
D
K
N
Q
L
R
L
L
R
T
-
R
L
T
M
V
F
Q
H
--
F
N
L
W
S
H
M
T
V
L
E
N
V
M
E
A
P
I
Q
V
L
G
L
S
K
H
D
A
R
E
R
A
L
K
Y
L
A
--
K
V
G
I
D
E
R
A
Q
--
G
K
-
Y
P
V
H
L
S
G
G
Q
Q
Q
R
V
S
I
A
R
A
L
A
M
E
P
D
V
L
L
F
D
E
P
T
S
A
L
D
P
E
L
V
G
E
V
L
R
I
M
-
Q
Q
L
-
A
E
-
E
G
K
T
M
V
V
V
T
H
E
M
G
F
A
R
H
V
S
S
H
V
I
F
L
H
Q
G
K
I
E
E
E
G
D
P
E
Q
V
F
G
N
P
Q
S
P
R
L
Q
Q
F
L
K
G
S
L
54
PsiBlast_CBE
63.10
40%
-42
- C1 -
3FVQ
3
FBPC_NEIG1
B:
[5-239]
-
L
H
I
G
H
L
S
K
S
F
Q
N
T
P
----
V
L
N
D
I
S
L
S
L
D
P
G
E
I
L
F
I
I
G
A
S
G
C
G
K
T
T
L
L
R
C
L
A
G
F
E
Q
P
D
S
G
E
I
S
L
----------
S
--------
G
K
T
I
F
S
--
K
N
T
N
-
L
P
V
-
R
E
R
R
L
G
Y
L
V
Q
E
--
G
V
L
F
P
H
L
T
V
Y
R
N
I
A
Y
G
L
G
N
G
K
G
R
T
A
Q
E
R
Q
-
R
I
E
A
M
L
E
--
L
T
G
I
S
E
L
-
A
--
G
R
-
Y
P
H
E
L
S
G
G
Q
Q
Q
R
A
A
L
A
R
A
L
A
P
D
P
E
L
I
L
L
D
E
P
F
S
A
L
D
E
Q
L
R
R
Q
I
R
E
D
M
I
A
A
L
-
R
A
-
N
G
K
S
A
V
F
V
S
H
D
R
E
E
A
L
Q
Y
A
D
R
I
A
V
M
K
Q
G
R
I
L
Q
T
A
S
P
H
E
L
Y
R
Q
P
A
D
L
D
A
A
L
F
I
----
45
PsiBlast_CBE
61.78
36%
-15
- C1 -
1VCI
1
?
A:
[13-249]
-
V
K
L
E
N
L
T
K
R
F
G
N
F
T
----
A
V
N
K
L
N
L
T
I
K
D
G
E
F
L
V
L
L
G
P
S
G
C
G
K
T
T
T
L
R
M
I
A
G
L
E
E
P
T
E
G
R
I
Y
F
----------
G
--------
D
R
D
V
T
Y
LP
P
K
D
R
--------
N
I
S
M
V
F
Q
--------
H
M
T
V
Y
E
N
I
A
F
-
P
L
--
K
K
F
P
K
D
E
I
D
K
R
V
R
W
A
A
E
--
L
L
Q
I
E
E
L
-
L
--
N
R
-
Y
P
A
Q
L
S
G
G
Q
R
Q
R
V
A
V
A
R
A
I
V
V
E
P
D
V
L
L
M
D
E
P
L
S
N
L
D
A
K
L
R
V
A
M
R
A
E
I
-
K
K
L
-
Q
Q
K
L
K
V
T
T
I
Y
V
T
H
D
Q
V
E
A
M
T
M
G
D
R
I
A
V
M
N
R
G
Q
L
L
Q
I
G
S
P
T
E
V
Y
L
R
P
N
S
V
F
V
A
T
F
I
----
55
PsiBlast_CBE
61.56
40%
-46
- C1 -
3FVQ
3
FBPC_NEIG1
A:
[5-244]
-
L
H
I
G
H
L
S
K
S
F
Q
N
T
P
----
V
L
N
D
I
S
L
S
L
D
P
G
E
I
L
F
I
I
G
A
S
G
C
G
K
T
T
L
L
R
C
L
A
G
F
E
Q
P
D
S
G
E
I
S
L
----------
S
--------
G
K
T
I
F
S
--
K
N
T
N
-
L
P
V
-
R
E
R
R
L
G
Y
L
V
Q
E
--
G
V
L
F
P
H
L
T
V
Y
R
N
I
A
Y
G
L
G
N
G
K
G
R
T
A
Q
E
R
Q
-
R
I
E
A
M
L
E
--
L
T
G
I
S
E
L
-
A
--
G
R
-
Y
P
H
E
L
S
G
G
Q
Q
Q
R
A
A
L
A
R
A
L
A
P
D
P
E
L
I
L
L
D
E
P
F
S
A
L
D
E
Q
L
R
R
Q
I
R
E
D
M
I
A
A
L
-
R
A
-
N
G
K
S
A
V
F
V
S
H
D
R
E
E
A
L
Q
Y
A
D
R
I
A
V
M
K
Q
G
R
I
L
Q
T
A
S
P
H
E
L
Y
R
Q
P
A
D
L
D
A
A
L
F
I
----
53
PsiBlast_CBE
61.49
38%
-23
- C1 -
4MKI
4
ECFA2_CALS4
A:
[27-245]
--------------------
L
K
D
I
N
F
S
I
D
D
E
E
F
V
G
I
I
G
H
T
G
S
G
K
S
T
L
I
Q
Q
L
N
G
L
L
K
P
S
K
G
K
I
Y
I
----------
N
--------
G
I
D
I
T
D
--
K
K
V
S
L
K
D
I
-
R
K
-
Q
V
G
L
V
F
Q
Y
PE
Y
Q
L
F
-
E
E
T
V
F
K
D
I
A
F
G
P
S
N
L
G
L
-
S
E
E
E
V
K
E
R
V
Y
E
A
M
E
--
I
V
G
I
S
K
E
-
L
--
A
D
K
S
P
F
E
L
S
G
G
Q
K
R
R
V
A
I
A
G
I
L
A
M
R
P
K
I
L
I
L
D
E
P
T
A
G
L
D
P
K
G
K
Q
E
I
L
N
K
I
-
K
E
I
-
H
D
K
Y
K
M
I
T
I
L
V
S
H
N
M
E
D
I
A
R
I
A
D
K
I
I
V
M
N
R
G
K
I
E
L
I
G
T
P
R
E
V
F
------
R
E
A
E
R
L
E
K
I
-
52
PsiBlast_CBE
60.70
38%
-21
- C1 -
4MKI
4
ECFA2_CALS4
B:
[27-245]
--------------------
L
K
D
I
N
F
S
I
D
D
E
E
F
V
G
I
I
G
H
T
G
S
G
K
S
T
L
I
Q
Q
L
N
G
L
L
K
P
S
K
G
K
I
Y
I
----------
N
--------
G
I
D
I
T
D
--
K
K
V
S
L
K
D
I
-
R
K
-
Q
V
G
L
V
F
Q
Y
PE
Y
Q
L
F
-
E
E
T
V
F
K
D
I
A
F
G
P
S
N
L
G
L
-
S
E
E
E
V
K
E
R
V
Y
E
A
M
E
--
I
V
G
I
S
K
E
-
L
--
A
D
K
S
P
F
E
L
S
G
G
Q
K
R
R
V
A
I
A
G
I
L
A
M
R
P
K
I
L
I
L
D
E
P
T
A
G
L
D
P
K
G
K
Q
E
I
L
N
K
I
-
K
E
I
-
H
D
K
Y
K
M
I
T
I
L
V
S
H
N
M
E
D
I
A
R
I
A
D
K
I
I
V
M
N
R
G
K
I
E
L
I
G
T
P
R
E
V
F
------
R
E
A
E
R
L
E
K
I
-
49
PsiBlast_CBE
47.23
39%
48
- C1 -
3TIF
7
Y796_METJA
A:
[1-223]
M
V
K
L
K
N
V
T
K
T
Y
K
M
G
E
E
I
I
Y
A
L
K
N
V
N
L
N
I
K
E
G
E
F
V
S
I
M
G
P
S
G
S
G
K
S
T
M
L
N
I
I
G
C
L
D
K
P
T
E
G
E
V
Y
I
----------
D
NIKTNDLD
D
D
E
L
T
K
--
I
R
-------
R
D
-
K
I
G
F
V
F
Q
Q
--
F
N
L
I
P
L
L
T
A
L
E
N
V
E
L
-
P
L
I
F
K
Y
R
G
A
M
S
G
E
E
R
R
K
R
A
L
E
C
L
K
M
A
E
L
E
E
-
R
FA
N
H
-
K
P
N
Q
L
S
G
G
Q
Q
Q
R
V
A
I
A
R
A
L
A
N
N
P
P
I
I
L
A
D
Q
P
T
W
A
L
D
S
K
T
G
E
K
I
M
Q
L
L
-
K
K
L
N
E
E
-
D
G
K
T
V
V
V
V
T
H
D
I
N
V
A
R
-
F
G
E
R
I
I
Y
L
K
D
G
E
V
--------------------------
47
PsiBlast_CBE
47.07
40%
47
- C1 -
1L2T
4
Y796_METJA
A:
[1-223]
M
I
K
L
K
N
V
T
K
T
Y
K
M
G
E
E
I
I
Y
A
L
K
N
V
N
L
N
I
K
E
G
E
F
V
S
I
M
G
P
S
G
S
G
K
S
T
M
L
N
I
I
G
C
L
D
K
P
T
E
G
E
V
Y
I
----------
D
NIKTNDLD
D
D
E
L
T
K
--
I
R
-------
R
D
-
K
I
G
F
V
F
Q
Q
--
F
N
L
I
P
L
L
T
A
L
E
N
V
E
L
-
P
L
I
F
K
Y
R
G
A
M
S
G
E
E
R
R
K
R
A
L
E
C
L
K
M
A
E
L
E
E
-
R
FA
N
H
-
K
P
N
Q
L
S
G
G
Q
Q
Q
R
V
A
I
A
R
A
L
A
N
N
P
P
I
I
L
A
D
Q
P
T
G
A
L
D
S
K
T
G
E
K
I
M
Q
L
L
-
K
K
L
N
E
E
-
D
G
K
T
V
V
V
V
T
H
D
I
N
V
A
R
-
F
G
E
R
I
I
Y
L
K
D
G
E
V
--------------------------
46
PsiBlast_CBE
45.36
40%
51
- C1 -
1L2T
4
Y796_METJA
B:
[1-223]
M
I
K
L
K
N
V
T
K
T
Y
K
M
G
E
EIIY
A
L
K
N
V
N
L
N
I
K
E
G
E
F
V
S
I
M
G
P
S
G
S
G
K
S
T
M
L
N
I
I
G
C
L
D
K
P
T
E
G
E
V
Y
I
----------
D
NIKTNDLD
D
D
E
L
T
K
--
I
R
-------
R
D
-
K
I
G
F
V
F
Q
Q
--
F
N
L
I
P
L
L
T
A
L
E
N
V
E
L
-
P
L
I
F
K
Y
R
G
A
M
S
G
E
E
R
R
K
R
A
L
E
CL
K
M
A
E
L
E
E
-
R
FA
N
H
-
K
P
N
Q
L
S
G
G
Q
Q
Q
R
V
A
I
A
R
A
L
A
N
N
P
P
I
I
L
A
D
Q
P
T
G
A
L
D
S
K
T
G
E
K
I
M
Q
L
L
-
K
K
L
N
E
E
-
D
G
K
T
V
V
V
V
T
H
D
I
N
V
A
R
-
F
G
E
R
I
I
Y
L
K
D
G
E
V
--------------------------
48
PsiBlast_CBE
44.66
39%
52
- C1 -
3TIF
7
Y796_METJA
B:
[1-223]
M
V
K
L
K
N
V
T
K
T
Y
K
M
G
E
EIIY
A
L
K
N
V
N
L
N
I
K
E
G
E
F
V
S
I
M
G
P
S
G
S
G
K
S
T
M
L
N
I
I
G
C
L
D
K
P
T
E
G
E
V
Y
I
----------
D
NIKTNDLD
D
D
E
L
T
K
--
I
R
-------
R
D
-
K
I
G
F
V
F
Q
Q
--
F
N
L
I
P
L
L
T
A
L
E
N
V
E
L
-
P
L
I
F
K
Y
R
G
A
M
S
G
E
E
R
R
K
R
A
L
E
CL
K
M
A
E
L
E
E
-
R
FA
N
H
-
K
P
N
Q
L
S
G
G
Q
Q
Q
R
V
A
I
A
R
A
L
A
N
N
P
P
I
I
L
A
D
Q
P
T
W
A
L
D
S
K
T
G
E
K
I
M
Q
L
L
-
K
K
L
N
E
E
-
D
G
K
T
V
V
V
V
T
H
D
I
N
V
A
R
-
F
G
E
R
I
I
Y
L
K
D
G
E
V
--------------------------