@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : bsu24160: (2016-07-08 )
MEIKQIMVAGAGQMGSGIAQTAADAGFYVRMYDVNPEAAEAGLKRLKKQLARDAEKGKRTETEVKSVINRISISQTLEEAEHADIVIEAIAENMAAKTEMFKTLDRICPPHTILASNTSSLPITEIAAVTNRPQRVIGMHFMNPVPVMKLVEVIRGLATSEETALDVMALAEKMGKTAVEVNDFPGFVSNRVLLPMINEAIYCVYEGVAKPEAIDEVMKLGMNHPMGPLALADFIGLDTCLSIMEVLHSGLGDSKYRPCPLLRKYVKAGWLGKKSGRGFYDYEEKTS
Atome Classification :
(39 SA)
.........10........20........30......---..40........50-..--......60........70........80...-......90........100.......110.......120.......130.......140.......150.......160.......170.......180........190.......200.......210.......220.......230.......240.......250...---....260.......270.......280.....
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
ME
I
K
Q
I
M
VAGAGQMGS
G
I
A
Q
T
AADA
G
F
Y
V
R
M
Y
DV
N
P
E
---
A
A
E
A
G
L
K
R
L
K
K
Q
L
A
-
R
D
--
A
E
KGKR
T
E
T
E
V
K
S
V
I
N
R
I
S
I
S
Q
T
L
E
EA-
E
H
A
-
D
I
V
I
E
A
I
A
E
N
M
A
A
K
T
E
M
F
K
T
L
D
R
ICPP
H
T
I
LASNTSSLP
I
T
E
I
A
A
VTNRP
Q
R
V
I
G
M
HFMNPV
P
V
M
K
L
V
E
V
I
R
G
LATS
E
E
T
A
L
D
V
M
A
L
A
E
K
MGK
T
A
V
EV-NDFP
G
F
VSN
R
V
L
L
P
M
I
N
E
A
I
Y
C
V
YEGVAK
P
E
A
I
D
E
V
M
K
LGMNHPM
G
P
L
A
L
A
D
F
I
G
L
D
T
C
L
S
I
M
E
V
L
HSGLGDSK---YRP
C
P
L
L
R
K
Y
V
K
AGWLGKKSGRGFYDYEEKTS
100
HHSearch
97.45
56%
-125
- C2 -
4R1N
-
?
A:
[1-282]
--
M
K
K
V
F
V
L
G
A
G
T
M
G
A
G
I
V
Q
A
F
A
A
K
G
C
E
V
I
V
R
D
I
K
E
E
---
F
V
D
R
G
I
A
T
I
T
K
S
L
S
-
K
L
--
V
A
K
E
K
I
T
E
A
D
K
E
E
I
L
S
R
I
S
G
T
T
D
M
K
L
A
-
A
D
C
-
D
L
V
V
E
A
A
I
E
N
M
K
I
K
K
E
I
F
A
E
L
D
G
I
C
K
P
E
T
I
L
A
S
N
T
S
S
L
S
I
T
E
V
A
S
A
T
K
R
A
D
K
V
I
G
M
H
F
F
N
P
A
P
V
M
K
L
V
E
V
I
R
G
A
A
T
S
Q
E
T
F
D
A
V
K
E
M
S
E
S
I
G
K
T
P
V
E
V
-
A
E
A
P
G
F
V
V
N
R
I
L
I
P
M
I
N
E
A
T
F
I
L
Q
E
G
V
A
K
E
E
D
I
D
A
A
M
K
L
G
A
N
H
P
M
G
P
L
A
L
G
D
L
I
G
L
D
V
C
L
A
I
M
D
V
L
Y
N
E
T
G
D
T
K
---
Y
R
A
S
S
L
L
R
K
Y
V
R
A
G
W
L
G
R
K
T
G
K
G
F
Y
D
Y
S
K
---
2
PsiBlast_PDB
97.01
55%
-125
- C2 -
4R1N
-
?
A:
[1-282]
--
M
K
K
V
F
V
L
G
A
G
T
M
G
A
G
I
V
Q
A
F
A
A
K
G
C
E
V
I
V
R
D
I
K
E
E
---
F
V
D
R
G
I
A
T
I
T
K
S
L
S
-
K
L
--
V
A
K
E
K
I
T
E
A
D
K
E
E
I
L
S
R
I
S
G
T
T
D
M
K
L
A
-
A
D
C
-
D
L
V
V
E
A
A
I
E
N
M
K
I
K
K
E
I
F
A
E
L
D
G
I
C
K
P
E
T
I
L
A
S
N
T
S
S
L
S
I
T
E
V
A
S
A
T
K
R
A
D
K
V
I
G
M
H
F
F
N
P
A
P
V
M
K
L
V
E
V
I
R
G
A
A
T
S
Q
E
T
F
D
A
V
K
E
M
S
E
S
I
G
K
T
P
V
E
V
-
A
E
A
P
G
F
V
V
N
R
I
L
I
P
M
I
N
E
A
T
F
I
L
Q
E
G
V
A
K
E
E
D
I
D
A
A
M
K
L
G
A
N
H
P
M
G
P
L
A
L
G
D
L
I
G
L
D
V
C
L
A
I
M
D
V
L
Y
N
E
T
G
D
T
K
---
Y
R
A
S
S
L
L
R
K
Y
V
R
A
G
W
L
G
R
K
T
G
K
G
F
Y
D
Y
S
K
---
3
PsiBlast_PDB
96.75
55%
-124
- C2 -
4KUG
1
?
A:
[1-282]
--
M
K
K
V
F
V
L
G
A
G
T
M
G
A
G
I
V
Q
A
F
A
A
K
G
C
E
V
I
V
R
D
I
K
E
E
---
F
V
D
R
G
I
A
T
I
T
K
S
L
S
-
K
L
--
V
A
K
E
K
I
T
E
A
D
K
E
E
I
L
S
R
I
S
G
T
T
D
M
K
L
A
-
A
D
C
-
D
L
V
V
E
A
A
I
E
N
M
K
I
K
K
E
I
F
A
E
L
D
G
I
C
K
P
E
T
I
L
A
S
N
T
S
S
L
S
I
T
E
V
A
S
A
T
K
R
A
D
K
V
I
G
M
H
F
F
N
P
A
P
V
M
K
L
V
E
V
I
R
G
A
A
T
S
Q
E
T
F
D
A
V
K
E
M
S
E
S
I
G
K
T
P
V
E
V
-
A
E
A
P
G
F
V
V
N
R
I
L
I
P
M
I
N
E
A
T
F
I
L
Q
E
G
V
A
K
E
E
D
I
D
A
A
M
K
L
G
A
N
H
P
M
G
P
L
A
L
G
D
L
I
G
L
D
V
C
L
A
I
M
D
V
L
Y
N
E
T
G
D
T
K
---
Y
R
A
S
S
L
L
R
K
Y
V
R
A
G
W
L
G
R
K
T
G
K
G
F
Y
D
Y
S
K
---
25
PsiBlast_CBE
96.44
56%
-122
- C2 -
4KUH
1
?
G:
[1-280]
--
M
K
K
V
F
V
L
G
A
G
T
M
G
A
G
I
V
Q
A
F
A
A
K
G
C
E
V
I
V
R
D
I
K
E
E
---
F
V
D
R
G
I
A
T
I
T
K
S
L
S
-
K
L
--
V
A
K
E
K
I
T
E
A
D
K
E
E
I
L
S
R
I
S
G
T
T
D
M
K
L
A
-
A
D
C
-
D
L
V
V
E
A
A
I
E
N
M
K
I
K
K
E
I
F
A
E
L
D
G
I
C
K
P
E
T
I
L
A
S
N
T
S
S
L
S
I
T
E
V
A
S
A
T
K
R
A
D
K
V
I
G
M
H
F
F
N
P
A
P
V
M
K
L
V
E
V
I
R
G
A
A
T
S
Q
E
T
F
D
A
V
K
E
M
S
E
S
I
G
K
T
P
V
E
V
-
A
E
A
P
G
F
V
V
N
R
I
L
I
P
M
I
N
E
A
T
F
I
L
Q
E
G
V
A
K
E
E
D
I
D
A
A
M
K
L
G
A
N
H
P
M
G
P
L
A
L
G
D
L
I
G
L
D
V
C
L
A
I
M
D
V
L
Y
N
E
T
G
D
T
K
---
Y
R
A
S
S
L
L
R
K
Y
V
R
A
G
W
L
G
R
K
T
G
K
G
F
Y
D
Y
-----
30
PsiBlast_CBE
95.99
56%
-121
- C2 -
4KUH
1
?
B:
[1-280]
--
M
K
K
V
F
V
L
G
A
G
T
M
G
A
G
I
V
Q
A
F
A
A
K
G
C
E
V
I
V
R
D
I
K
E
E
---
F
V
D
R
G
I
A
T
I
T
K
S
L
S
-
K
L
--
V
A
K
E
K
I
T
E
A
D
K
E
E
I
L
S
R
I
S
G
T
T
D
M
K
L
A
-
A
D
C
-
D
L
V
V
E
A
A
I
E
N
M
K
I
K
K
E
I
F
A
E
L
D
G
I
C
K
P
E
T
I
L
A
S
N
T
S
S
L
S
I
T
E
V
A
S
A
T
K
R
A
D
K
V
I
G
M
H
F
F
N
P
A
P
V
M
K
L
V
E
V
I
R
G
A
A
T
S
Q
E
T
F
D
A
V
K
E
M
S
E
S
I
G
K
T
P
V
E
V
-
A
E
A
P
G
F
V
V
N
R
I
L
I
P
M
I
N
E
A
T
F
I
L
Q
E
G
V
A
K
E
E
D
I
D
A
A
M
K
L
G
A
N
H
P
M
G
P
L
A
L
G
D
L
I
G
L
D
V
C
L
A
I
M
D
V
L
Y
N
E
T
G
D
T
K
---
Y
R
A
S
S
L
L
R
K
Y
V
R
A
G
W
L
G
R
K
T
G
K
G
F
Y
D
Y
-----
28
PsiBlast_CBE
95.83
56%
-121
- C2 -
4KUH
1
?
D:
[1-280]
--
M
K
K
V
F
V
L
G
A
G
T
M
G
A
G
I
V
Q
A
F
A
A
K
G
C
E
V
I
V
R
D
I
K
E
E
---
F
V
D
R
G
I
A
T
I
T
K
S
L
S
-
K
L
--
V
A
K
E
K
I
T
E
A
D
K
E
E
I
L
S
R
I
S
G
T
T
D
M
K
L
A
-
A
D
C
-
D
L
V
V
E
A
A
I
E
N
M
K
I
K
K
E
I
F
A
E
L
D
G
I
C
K
P
E
T
I
L
A
S
N
T
S
S
L
S
I
T
E
V
A
S
A
T
K
R
A
D
K
V
I
G
M
H
F
F
N
P
A
P
V
M
K
L
V
E
V
I
R
G
A
A
T
S
Q
E
T
F
D
A
V
K
E
M
S
E
S
I
G
K
T
P
V
E
V
-
A
E
A
P
G
F
V
V
N
R
I
L
I
P
M
I
N
E
A
T
F
I
L
Q
E
G
V
A
K
E
E
D
I
D
A
A
M
K
L
G
A
N
H
P
M
G
P
L
A
L
G
D
L
I
G
L
D
V
C
L
A
I
M
D
V
L
Y
N
E
T
G
D
T
K
---
Y
R
A
S
S
L
L
R
K
Y
V
R
A
G
W
L
G
R
K
T
G
K
G
F
Y
D
Y
-----
4
PsiBlast_PDB
95.66
56%
-121
- C2 -
4KUH
1
?
A:
[1-280]
--
M
K
K
V
F
V
L
G
A
G
T
M
G
A
G
I
V
Q
A
F
A
A
K
G
C
E
V
I
V
R
D
I
K
E
E
---
F
V
D
R
G
I
A
T
I
T
K
S
L
S
-
K
L
--
V
A
K
E
K
I
T
E
A
D
K
E
E
I
L
S
R
I
S
G
T
T
D
M
K
L
A
-
A
D
C
-
D
L
V
V
E
A
A
I
E
N
M
K
I
K
K
E
I
F
A
E
L
D
G
I
C
K
P
E
T
I
L
A
S
N
T
S
S
L
S
I
T
E
V
A
S
A
T
K
R
A
D
K
V
I
G
M
H
F
F
N
P
A
P
V
M
K
L
V
E
V
I
R
G
A
A
T
S
Q
E
T
F
D
A
V
K
E
M
S
E
S
I
G
K
T
P
V
E
V
-
A
E
A
P
G
F
V
V
N
R
I
L
I
P
M
I
N
E
A
T
F
I
L
Q
E
G
V
A
K
E
E
D
I
D
A
A
M
K
L
G
A
N
H
P
M
G
P
L
A
L
G
D
L
I
G
L
D
V
C
L
A
I
M
D
V
L
Y
N
E
T
G
D
T
K
---
Y
R
A
S
S
L
L
R
K
Y
V
R
A
G
W
L
G
R
K
T
G
K
G
F
Y
D
Y
-----
29
PsiBlast_CBE
95.47
56%
-118
- C2 -
4KUH
1
?
C:
[1-280]
--
M
K
K
V
F
V
L
G
A
G
T
M
G
A
G
I
V
Q
A
F
A
A
K
G
C
E
V
I
V
R
D
I
K
E
E
---
F
V
D
R
G
I
A
T
I
T
K
S
L
S
-
K
L
--
V
A
K
E
K
I
T
E
A
D
K
E
E
I
L
S
R
I
S
G
T
T
D
M
K
L
A
-
A
D
C
-
D
L
V
V
E
A
A
I
E
N
M
K
I
K
K
E
I
F
A
E
L
D
G
I
C
K
P
E
T
I
L
A
S
N
T
S
S
L
S
I
T
E
V
A
S
A
T
K
R
A
D
K
V
I
G
M
H
F
F
N
P
A
P
V
M
K
L
V
E
V
I
R
G
A
A
T
S
Q
E
T
F
D
A
V
K
E
M
S
E
S
I
G
K
T
P
V
E
V
-
A
E
A
P
G
F
V
V
N
R
I
L
I
P
M
I
N
E
A
T
F
I
L
Q
E
G
V
A
K
E
E
D
I
D
A
A
M
K
L
G
A
N
H
P
M
G
P
L
A
L
G
D
L
I
G
L
D
V
C
L
A
I
M
D
V
L
Y
N
E
T
G
D
T
K
---
Y
R
A
S
S
L
L
R
K
Y
V
R
A
G
W
L
G
R
K
T
G
K
G
F
Y
D
Y
-----
27
PsiBlast_CBE
95.24
56%
-120
- C2 -
4KUH
2
?
E:
[1-280]
--
M
K
K
V
F
V
L
G
A
G
T
M
G
A
G
I
V
Q
A
F
A
A
K
G
C
E
V
I
V
R
D
I
K
E
E
---
F
V
D
R
G
I
A
T
I
T
K
S
L
S
-
K
L
--
V
A
K
E
K
I
T
E
A
D
K
E
E
I
L
S
R
I
S
G
T
T
D
M
K
L
A
-
A
D
C
-
D
L
V
V
E
A
A
I
E
N
M
K
I
K
K
E
I
F
A
E
L
D
G
I
C
K
P
E
T
I
L
A
S
N
T
S
S
L
S
I
T
E
V
A
S
A
T
K
R
A
D
K
V
I
G
M
H
F
F
N
P
A
P
V
M
K
L
V
E
V
I
R
G
A
A
T
S
Q
E
T
F
D
A
V
K
E
M
S
E
S
I
G
K
T
P
V
E
V
-
A
E
A
P
G
F
V
V
N
R
I
L
I
P
M
I
N
E
A
T
F
I
L
Q
E
G
V
A
K
E
E
D
I
D
A
A
M
K
L
G
A
N
H
P
M
G
P
L
A
L
G
D
L
I
G
L
D
V
C
L
A
I
M
D
V
L
Y
N
E
T
G
D
T
K
---
Y
R
A
S
S
L
L
R
K
Y
V
R
A
G
W
L
G
R
K
T
G
K
G
F
Y
D
Y
-----
23
PsiBlast_CBE
95.16
55%
-123
- C2 -
4KUG
1
?
B:
[1-282]
--
M
K
K
V
F
V
L
G
A
G
T
M
G
A
G
I
V
Q
A
F
A
A
K
G
C
E
V
I
V
R
D
I
K
E
E
---
F
V
D
R
G
I
A
T
I
T
K
S
L
S
-
K
L
--
V
A
K
E
K
I
T
E
A
D
K
E
E
I
L
S
R
I
S
G
T
T
D
M
K
L
A
-
A
D
C
-
D
L
V
V
E
A
A
I
E
N
M
K
I
K
K
E
I
F
A
E
L
D
G
I
C
K
P
E
T
I
L
A
S
N
T
S
S
L
S
I
T
E
V
A
S
A
T
K
R
A
D
K
V
I
G
M
H
F
F
N
P
A
P
V
M
K
L
V
E
V
I
R
G
A
A
T
S
Q
E
T
F
D
A
V
K
E
M
S
E
S
I
G
K
T
P
V
E
V
-
A
E
A
P
G
F
V
V
N
R
I
L
I
P
M
I
N
E
A
T
F
I
L
Q
E
G
V
A
K
E
E
D
I
D
A
A
M
K
L
G
A
N
H
P
M
G
P
L
A
L
G
D
L
I
G
L
D
V
C
L
A
I
M
D
V
L
Y
N
E
T
G
D
T
K
---
Y
R
A
S
S
L
L
R
K
Y
V
R
A
G
W
L
G
R
K
T
G
K
G
F
Y
D
Y
S
K
---
22
PsiBlast_CBE
95.02
55%
-122
- C2 -
4KUG
1
?
C:
[1-282]
--
M
K
K
V
F
V
L
G
A
G
T
M
G
A
G
I
V
Q
A
F
A
A
K
G
C
E
V
I
V
R
D
I
K
E
E
---
F
V
D
R
G
I
A
T
I
T
K
S
L
S
-
K
L
--
V
A
K
E
K
I
T
E
A
D
K
E
E
I
L
S
R
I
S
G
T
T
D
M
K
L
A
-
A
D
C
-
D
L
V
V
E
A
A
I
E
N
M
K
I
K
K
E
I
F
A
E
L
D
G
I
C
K
P
E
T
I
L
A
S
N
T
S
S
L
S
I
T
E
V
A
S
A
T
K
R
A
D
K
V
I
G
M
H
F
F
N
P
A
P
V
M
K
L
V
E
V
I
R
G
A
A
T
S
Q
E
T
F
D
A
V
K
E
M
S
E
S
I
G
K
T
P
V
E
V
-
A
E
A
P
G
F
V
V
N
R
I
L
I
P
M
I
N
E
A
T
F
I
L
Q
E
G
V
A
K
E
E
D
I
D
A
A
M
K
L
G
A
N
H
P
M
G
P
L
A
L
G
D
L
I
G
L
D
V
C
L
A
I
M
D
V
L
Y
N
E
T
G
D
T
K
---
Y
R
A
S
S
L
L
R
K
Y
V
R
A
G
W
L
G
R
K
T
G
K
G
F
Y
D
Y
S
K
---
24
PsiBlast_CBE
94.67
56%
-115
- C2 -
4KUH
1
?
H:
[1-280]
--
M
K
K
V
F
V
L
G
A
G
T
M
G
A
G
I
V
Q
A
F
A
A
K
G
C
E
V
I
V
R
D
I
K
E
E
---
F
V
D
R
G
I
A
T
I
T
K
S
L
S
-
K
L
--
V
A
K
E
K
I
T
E
A
D
K
E
E
I
L
S
R
I
S
G
T
T
D
M
K
L
A
-
A
D
C
-
D
L
V
V
E
A
A
I
E
N
M
K
I
K
K
E
I
F
A
E
L
D
G
I
C
K
P
E
T
I
L
A
S
N
T
S
S
L
S
I
T
E
V
A
S
A
T
K
R
A
D
K
V
I
G
M
H
F
F
N
P
A
P
V
M
K
L
V
E
V
I
R
G
A
A
T
S
Q
E
T
F
D
A
V
K
E
M
S
E
S
I
G
K
T
P
V
E
V
-
A
E
A
P
G
F
V
V
N
R
I
L
I
P
M
I
N
E
A
T
F
I
L
Q
E
G
V
A
K
E
E
D
I
D
A
A
M
K
L
G
A
N
H
P
M
G
P
L
A
L
G
D
L
I
G
L
D
V
C
L
A
I
M
D
V
L
Y
N
E
T
G
D
T
K
---
Y
R
A
S
S
L
L
R
K
Y
V
R
A
G
W
L
G
R
K
T
G
K
G
F
Y
D
Y
-----
1
PsiBlast_PDB
94.65
55%
-122
- C2 -
4KUE
-
?
A:
[1-280]
--
M
K
K
V
F
V
L
G
A
G
T
M
G
A
G
I
V
Q
A
F
A
A
K
G
C
E
V
I
V
R
D
I
K
E
E
---
F
V
D
R
G
I
A
T
I
T
K
S
L
S
-
K
L
--
V
A
K
E
K
I
T
E
A
D
K
E
E
I
L
S
R
I
S
G
T
T
D
M
K
L
A
-
A
D
C
-
D
L
V
V
E
A
A
I
E
N
M
K
I
K
K
E
I
F
A
E
L
D
G
I
C
K
P
E
T
I
L
A
S
N
T
S
S
L
S
I
T
E
V
A
S
A
T
K
R
A
D
K
V
I
G
M
H
F
F
N
P
A
P
V
M
K
L
V
E
V
I
R
G
A
A
T
S
Q
E
T
F
D
A
V
K
E
M
S
E
S
I
G
K
T
P
V
E
V
-
A
E
A
P
G
F
V
V
N
R
I
L
I
P
M
I
N
E
A
T
F
I
L
Q
E
G
V
A
K
E
E
D
I
D
A
A
M
K
L
G
A
N
H
P
M
G
P
L
A
L
G
D
L
I
G
L
D
V
C
L
A
I
M
D
V
L
Y
N
E
T
G
D
T
K
---
Y
R
A
S
S
L
L
R
K
Y
V
R
A
G
W
L
G
R
K
T
G
K
G
F
Y
D
Y
-----
26
PsiBlast_CBE
94.60
56%
-117
- C2 -
4KUH
2
?
F:
[1-280]
--
M
K
K
V
F
V
L
G
A
G
T
M
G
A
G
I
V
Q
A
F
A
A
K
G
C
E
V
I
V
R
D
I
K
E
E
---
F
V
D
R
G
I
A
T
I
T
K
S
L
S
-
K
L
--
V
A
K
E
K
I
T
E
A
D
K
E
E
I
L
S
R
I
S
G
T
T
D
M
K
L
A
-
A
D
C
-
D
L
V
V
E
A
A
I
E
N
M
K
I
K
K
E
I
F
A
E
L
D
G
I
C
K
P
E
T
I
L
A
S
N
T
S
S
L
S
I
T
E
V
A
S
A
T
K
R
A
D
K
V
I
G
M
H
F
F
N
P
A
P
V
M
K
L
V
E
V
I
R
G
A
A
T
S
Q
E
T
F
D
A
V
K
E
M
S
E
S
I
G
K
T
P
V
E
V
-
A
E
A
P
G
F
V
V
N
R
I
L
I
P
M
I
N
E
A
T
F
I
L
Q
E
G
V
A
K
E
E
D
I
D
A
A
M
K
L
G
A
N
H
P
M
G
P
L
A
L
G
D
L
I
G
L
D
V
C
L
A
I
M
D
V
L
Y
N
E
T
G
D
T
K
---
Y
R
A
S
S
L
L
R
K
Y
V
R
A
G
W
L
G
R
K
T
G
K
G
F
Y
D
Y
-----
21
PsiBlast_CBE
93.85
55%
-120
- C2 -
4KUG
1
?
D:
[1-282]
--
M
K
K
V
F
V
L
G
A
G
T
M
G
A
G
I
V
Q
A
F
A
A
K
G
C
E
V
I
V
R
D
I
K
E
E
---
F
V
D
R
G
I
A
T
I
T
K
S
L
S
-
K
L
--
V
A
K
E
K
I
T
E
A
D
K
E
E
I
L
S
R
I
S
G
T
T
D
M
K
L
A
-
A
D
C
-
D
L
V
V
E
A
A
I
E
N
M
K
I
K
K
E
I
F
A
E
L
D
G
I
C
K
P
E
T
I
L
A
S
N
T
S
S
L
S
I
T
E
V
A
S
A
T
K
R
A
D
K
V
I
G
M
H
F
F
N
P
A
P
V
M
K
L
V
E
V
I
R
G
A
A
T
S
Q
E
T
F
D
A
V
K
E
M
S
E
S
I
G
K
T
P
V
E
V
-
A
E
A
P
G
F
V
V
N
R
I
L
I
P
M
I
N
E
A
T
F
I
L
Q
E
G
V
A
K
E
E
D
I
D
A
A
M
K
L
G
A
N
H
P
M
G
P
L
A
L
G
D
L
I
G
L
D
V
C
L
A
I
M
D
V
L
Y
N
E
T
G
D
T
K
---
Y
R
A
S
S
L
L
R
K
Y
V
R
A
G
W
L
G
R
K
T
G
K
G
F
Y
D
Y
S
K
---
44
PsiBlast_CBE
92.63
51%
-127
- C2 -
4PZD
1
?
D:
[2-284]
-
S
I
R
T
V
G
I
V
G
A
G
T
M
G
N
G
I
A
Q
A
C
A
V
V
G
L
N
V
V
M
V
D
I
S
D
A
---
A
V
Q
K
G
V
A
T
V
A
S
S
L
D
-
R
L
--
I
K
K
E
K
L
T
E
A
D
K
A
S
A
L
A
R
I
K
G
S
T
S
Y
D
D
L
-
K
A
T
-
D
I
V
I
E
A
A
T
E
N
Y
D
L
K
V
K
I
L
K
Q
I
D
G
I
V
G
E
N
V
I
I
A
S
N
T
S
S
I
S
I
T
K
L
A
A
V
T
S
R
A
D
R
F
I
G
M
H
F
F
N
P
V
P
V
M
A
L
V
E
L
I
R
G
L
Q
T
S
D
T
T
H
A
A
V
E
A
L
S
K
Q
L
G
K
Y
P
I
T
V
-
K
N
S
P
G
F
V
V
N
R
I
L
C
P
M
I
N
E
A
F
C
V
L
G
E
G
L
A
S
P
E
E
I
D
E
G
M
K
L
G
C
N
H
P
I
G
P
L
A
L
A
D
M
I
G
L
D
T
M
L
A
V
M
E
V
L
Y
T
E
F
A
D
P
K
---
Y
R
P
A
M
L
M
R
E
M
V
A
A
G
Y
L
G
R
K
T
G
R
G
V
Y
V
Y
S
K
---
40
PsiBlast_CBE
92.16
51%
-136
- C2 -
4PZD
1
?
H:
[2-284]
-
S
I
R
T
V
G
I
V
G
A
G
T
M
G
N
G
I
A
Q
A
C
A
V
V
G
L
N
V
V
M
V
D
I
S
D
A
---
A
V
Q
K
G
V
A
T
V
A
S
S
L
D
-
R
L
--
I
K
K
E
K
L
T
E
A
D
K
A
S
A
L
A
R
I
K
G
S
T
S
Y
D
D
L
-
K
A
T
-
D
I
V
I
E
A
A
T
E
N
Y
D
L
K
V
K
I
L
K
Q
I
D
G
I
V
G
E
N
V
I
I
A
S
N
T
S
S
I
S
I
T
K
L
A
A
V
T
S
R
A
D
R
F
I
G
M
H
F
F
N
P
V
P
V
M
A
L
V
E
L
I
R
G
L
Q
T
S
D
T
T
H
A
A
V
E
A
L
S
K
Q
L
G
K
Y
P
I
T
V
-
K
N
S
P
G
F
V
V
N
R
I
L
C
P
M
I
N
E
A
F
C
V
L
G
E
G
L
A
S
P
E
E
I
D
E
G
M
K
L
G
C
N
H
P
I
G
P
L
A
L
A
D
M
I
G
L
D
T
M
L
A
V
M
E
V
L
Y
T
E
F
A
D
P
K
---
Y
R
P
A
M
L
M
R
E
M
V
A
A
G
Y
L
G
R
K
T
G
R
G
V
Y
V
Y
S
K
---
99
HHSearch
91.95
51%
-126
- C2 -
4PZC
-
?
A:
[2-284]
-
S
I
R
T
V
G
I
V
G
A
G
T
M
G
N
G
I
A
Q
A
C
A
V
V
G
L
N
V
V
M
V
D
I
S
D
A
---
A
V
Q
K
G
V
A
T
V
A
S
S
L
D
-
R
L
--
I
K
K
E
K
L
T
E
A
D
K
A
S
A
L
A
R
I
K
G
S
T
S
Y
D
D
L
-
K
A
T
-
D
I
V
I
E
A
A
T
E
N
Y
D
L
K
V
K
I
L
K
Q
I
D
G
I
V
G
E
N
V
I
I
A
S
N
T
S
S
I
S
I
T
K
L
A
A
V
T
S
R
A
D
R
F
I
G
M
H
F
F
N
P
V
P
V
M
A
L
V
E
L
I
R
G
L
Q
T
S
D
T
T
H
A
A
V
E
A
L
S
K
Q
L
G
K
Y
P
I
T
V
-
K
N
S
P
G
F
V
V
N
R
I
L
C
P
M
I
N
E
A
F
C
V
L
G
E
G
L
A
S
P
E
E
I
D
E
G
M
K
L
G
C
N
H
P
I
G
P
L
A
L
A
D
M
I
G
L
D
T
M
L
A
V
M
E
V
L
Y
T
E
F
A
D
P
K
---
Y
R
P
A
M
L
M
R
E
M
V
A
A
G
Y
L
G
R
K
T
G
R
G
V
Y
V
Y
S
K
---
5
PsiBlast_PDB
91.95
51%
-126
- C2 -
4PZC
-
?
A:
[2-284]
-
S
I
R
T
V
G
I
V
G
A
G
T
M
G
N
G
I
A
Q
A
C
A
V
V
G
L
N
V
V
M
V
D
I
S
D
A
---
A
V
Q
K
G
V
A
T
V
A
S
S
L
D
-
R
L
--
I
K
K
E
K
L
T
E
A
D
K
A
S
A
L
A
R
I
K
G
S
T
S
Y
D
D
L
-
K
A
T
-
D
I
V
I
E
A
A
T
E
N
Y
D
L
K
V
K
I
L
K
Q
I
D
G
I
V
G
E
N
V
I
I
A
S
N
T
S
S
I
S
I
T
K
L
A
A
V
T
S
R
A
D
R
F
I
G
M
H
F
F
N
P
V
P
V
M
A
L
V
E
L
I
R
G
L
Q
T
S
D
T
T
H
A
A
V
E
A
L
S
K
Q
L
G
K
Y
P
I
T
V
-
K
N
S
P
G
F
V
V
N
R
I
L
C
P
M
I
N
E
A
F
C
V
L
G
E
G
L
A
S
P
E
E
I
D
E
G
M
K
L
G
C
N
H
P
I
G
P
L
A
L
A
D
M
I
G
L
D
T
M
L
A
V
M
E
V
L
Y
T
E
F
A
D
P
K
---
Y
R
P
A
M
L
M
R
E
M
V
A
A
G
Y
L
G
R
K
T
G
R
G
V
Y
V
Y
S
K
---
41
PsiBlast_CBE
91.82
51%
-124
- C2 -
4PZD
1
?
G:
[2-284]
-
S
I
R
T
V
G
I
V
G
A
G
T
M
G
N
G
I
A
Q
A
C
A
V
V
G
L
N
V
V
M
V
D
I
S
D
A
---
A
V
Q
K
G
V
A
T
V
A
S
S
L
D
-
R
L
--
I
K
K
E
K
L
T
E
A
D
K
A
S
A
L
A
R
I
K
G
S
T
S
Y
D
D
L
-
K
A
T
-
D
I
V
I
E
A
A
T
E
N
Y
D
L
K
V
K
I
L
K
Q
I
D
G
I
V
G
E
N
V
I
I
A
S
N
T
S
S
I
S
I
T
K
L
A
A
V
T
S
R
A
D
R
F
I
G
M
H
F
F
N
P
V
P
V
M
A
L
V
E
L
I
R
G
L
Q
T
S
D
T
T
H
A
A
V
E
A
L
S
K
Q
L
G
K
Y
P
I
T
V
-
K
N
S
P
G
F
V
V
N
R
I
L
C
P
M
I
N
E
A
F
C
V
L
G
E
G
L
A
S
P
E
E
I
D
E
G
M
K
L
G
C
N
H
P
I
G
P
L
A
L
A
D
M
I
G
L
D
T
M
L
A
V
M
E
V
L
Y
T
E
F
A
D
P
K
---
Y
R
P
A
M
L
M
R
E
M
V
A
A
G
Y
L
G
R
K
T
G
R
G
V
Y
V
Y
S
K
---
8
PsiBlast_PDB
67.79
41%
-11
- C2 -
1F0Y
3
HCDH_HUMAN
A:
[15-302]
--
V
K
H
V
T
V
I
G
G
G
L
M
G
A
G
I
A
Q
V
A
A
A
T
G
H
T
V
V
L
V
D
Q
T
E
D
I
L
A
K
S
K
K
G
I
E
E
S
L
R
K
V
A
-
K
K
K
F
A
E
N
P
K
A
G
D
E
F
V
E
K
T
L
S
T
I
A
T
S
T
D
A
A
S
V
-
V
H
S
T
D
L
V
V
E
A
I
V
E
N
L
K
V
K
N
E
L
F
K
R
L
D
K
F
A
A
E
H
T
I
F
A
S
N
T
S
S
L
Q
I
T
S
I
A
N
A
T
T
R
Q
D
R
F
A
G
L
H
F
F
N
P
V
P
V
M
K
L
V
E
V
I
K
T
P
M
T
S
Q
K
T
F
E
S
L
V
D
F
S
K
A
L
G
K
H
P
V
S
C
-
K
D
T
P
G
F
I
V
N
R
L
L
V
P
Y
L
M
E
A
I
R
L
Y
E
R
G
D
A
S
K
E
D
I
D
T
A
M
K
L
G
A
G
Y
P
M
G
P
F
E
L
L
D
Y
V
G
L
D
T
T
K
F
I
V
D
G
W
H
E
M
D
A
E
N
P
L--
H
Q
P
S
P
S
L
N
K
L
V
A
E
N
K
F
G
K
K
T
G
E
G
F
Y
K
Y
K
----
16
PsiBlast_PDB
67.73
41%
-12
- C2 -
3HAD
1
HCDH_HUMAN
A:
[15-302]
--
V
K
H
V
T
V
I
G
G
G
L
M
G
A
G
I
A
Q
V
A
A
A
T
G
H
T
V
V
L
V
D
Q
T
E
D
I
L
A
K
S
K
K
G
I
E
E
S
L
R
K
V
A
-
K
K
K
F
A
E
N
P
K
A
G
D
E
F
V
E
K
T
L
S
T
I
A
T
S
T
D
A
A
S
V
-
V
H
S
T
D
L
V
V
E
A
I
V
E
N
L
K
V
K
N
E
L
F
K
R
L
D
K
R
A
A
E
H
T
I
F
A
S
N
T
S
S
L
Q
I
T
S
I
A
N
A
T
T
R
Q
D
R
F
A
G
L
H
F
F
N
P
V
P
V
M
K
L
V
E
V
I
K
T
P
M
T
S
Q
K
T
F
E
S
L
V
D
F
S
K
A
L
G
K
H
P
V
S
C
-
K
D
T
P
G
F
I
V
N
R
L
L
V
P
Y
L
M
E
A
I
R
L
Y
E
R
G
D
A
S
K
E
D
I
D
T
A
M
K
L
G
A
G
Y
P
M
G
P
F
E
L
L
D
Y
V
G
L
D
T
T
K
F
I
V
D
G
W
H
E
M
D
A
E
N
P
L--
H
Q
P
S
P
S
L
N
K
L
V
A
E
N
K
F
G
K
K
T
G
E
G
F
Y
K
Y
K
----
17
PsiBlast_PDB
67.65
41%
-15
- C2 -
1M76
3
HCDH_HUMAN
A:
[15-302]
--
V
K
H
V
T
V
I
G
G
G
L
M
G
A
G
I
A
Q
V
A
A
A
T
G
H
T
V
V
L
V
D
Q
T
E
D
I
L
A
K
S
K
K
G
I
E
E
S
L
R
K
V
A
-
K
K
K
F
A
E
N
P
K
A
G
D
E
F
V
E
K
T
L
S
T
I
A
T
S
T
D
A
A
S
V
-
V
H
S
T
D
L
V
V
E
A
I
V
E
N
L
K
V
K
N
E
L
F
K
R
L
D
K
F
A
A
E
H
T
I
F
A
S
N
T
C
S
L
Q
I
T
S
I
A
N
A
T
T
R
Q
D
R
F
A
G
L
H
F
F
N
P
V
P
V
M
K
L
V
E
V
I
K
T
P
M
T
S
Q
K
T
F
E
S
L
V
D
F
S
K
A
L
G
K
H
P
V
S
C
-
K
D
T
P
G
F
I
V
N
R
L
L
V
P
Y
L
M
E
A
I
R
L
Y
E
R
G
D
A
S
K
E
D
I
D
T
A
M
K
L
G
A
G
Y
P
M
G
P
F
E
L
L
D
Y
V
G
L
D
T
T
K
F
I
V
D
G
W
H
E
M
D
A
E
N
P
L--
H
Q
P
S
P
S
L
N
K
L
V
A
E
N
K
F
G
K
K
T
G
E
G
F
Y
K
Y
K
----
11
PsiBlast_PDB
67.28
41%
-16
- C2 -
1F17
1
HCDH_HUMAN
A:
[15-302]
--
V
K
H
V
T
V
I
G
G
G
L
M
G
A
G
I
A
Q
V
A
A
A
T
G
H
T
V
V
L
V
D
Q
T
E
D
I
L
A
K
S
K
K
G
I
E
E
S
L
R
K
V
A
-
K
K
KF
A
E
N
P
K
A
G
D
E
C
V
E
K
T
L
S
T
I
A
T
S
T
D
A
A
S
V
-
V
H
S
T
D
L
V
V
E
A
I
V
E
N
L
K
V
K
N
E
L
F
K
R
L
D
K
F
A
A
E
H
T
I
F
A
S
N
T
S
S
L
Q
I
T
S
I
A
N
A
T
T
R
Q
D
R
F
A
G
L
H
F
F
N
P
V
P
V
M
K
L
V
E
V
I
K
T
P
M
T
S
Q
K
T
F
E
S
L
V
D
F
S
K
A
L
G
K
H
P
V
S
C
-
K
D
T
P
G
F
I
V
N
R
L
L
V
P
Y
L
M
E
A
I
R
L
Y
E
R
G
D
A
S
K
E
D
I
D
T
A
M
K
L
G
A
G
Y
P
M
G
P
F
E
L
L
D
Y
V
G
L
D
T
T
K
F
I
V
D
G
W
H
E
M
D
A
E
N
P
L--
H
Q
P
S
P
S
L
N
K
L
V
A
E
N
K
F
G
K
K
T
G
E
G
F
Y
K
Y
K
----
55
PsiBlast_CBE
67.21
41%
-12
- C2 -
1M76
3
HCDH_HUMAN
B:
[15-302]
--
V
K
H
V
T
V
I
G
G
G
L
M
G
A
G
I
A
Q
V
A
A
A
T
G
H
T
V
V
L
V
D
Q
T
E
D
ILA
K
S
K
K
G
I
E
E
S
L
R
K
V
A
-
K
K
KF
A
E
N
P
K
A
G
D
E
F
V
E
K
T
L
S
T
I
A
T
S
T
D
A
A
S
V
-
V
H
S
T
D
L
V
V
E
A
I
V
E
N
L
K
V
K
N
E
L
F
K
R
L
D
K
F
A
A
E
H
T
I
F
A
S
N
T
C
S
L
Q
I
T
S
I
A
N
A
T
T
R
Q
D
R
F
A
G
L
H
F
F
N
P
V
P
V
M
K
L
V
E
V
I
K
T
P
M
T
S
Q
K
T
F
E
S
L
V
D
F
S
K
A
L
G
K
H
P
V
S
C
-
K
D
T
P
G
F
I
V
N
R
L
L
V
P
Y
L
M
E
A
I
R
L
Y
E
R
G
D
A
S
K
E
D
I
D
T
A
M
K
L
G
A
G
Y
P
M
G
P
F
E
L
L
D
Y
V
G
L
D
T
T
K
F
I
V
D
G
W
H
E
M
D
A
E
N
P
L--
H
Q
P
S
P
S
L
N
K
L
V
A
E
N
K
F
G
K
K
T
G
E
G
F
Y
K
Y
K
----
48
PsiBlast_CBE
67.16
41%
-14
- C2 -
1F17
1
HCDH_HUMAN
B:
[15-302]
--
V
K
H
V
T
V
I
G
G
G
L
M
G
A
G
I
A
Q
V
A
A
A
T
G
H
T
V
V
L
V
D
Q
T
E
D
ILA
K
S
K
K
G
I
E
E
S
L
R
K
V
A
-
K
K
KF
A
E
N
P
K
A
G
D
E
C
V
E
K
T
L
S
T
I
A
T
S
T
D
A
A
S
V
-
V
H
S
T
D
L
V
V
E
A
I
V
E
N
L
K
V
K
N
E
L
F
K
R
L
D
K
F
A
A
E
H
T
I
F
A
S
N
T
S
S
L
Q
I
T
S
I
A
N
A
T
T
R
Q
D
R
F
A
G
L
H
F
F
N
P
V
P
V
M
K
L
V
E
V
I
K
T
P
M
T
S
Q
K
T
F
E
S
L
V
D
F
S
K
A
L
G
K
H
P
V
S
C
-
K
D
T
P
G
F
I
V
N
R
L
L
V
P
Y
L
M
E
A
I
R
L
Y
E
R
G
D
A
S
K
E
D
I
D
T
A
M
K
L
G
A
G
Y
P
M
G
P
F
E
L
L
D
Y
V
G
L
D
T
T
K
F
I
V
D
G
W
H
E
M
D
A
E
N
P
L--
H
Q
P
S
P
S
L
N
K
L
V
A
E
N
K
F
G
K
K
T
G
E
G
F
Y
K
Y
K
----
15
PsiBlast_PDB
66.86
41%
-18
- C2 -
1LSO
1
HCDH_HUMAN
A:
[15-302]
--
V
K
H
V
T
V
I
G
G
G
L
M
G
A
G
I
A
Q
V
A
A
A
T
G
H
T
V
V
L
V
D
Q
T
E
D
I
L
A
K
S
K
K
G
I
E
E
S
L
R
K
V
A
-
K
K
K
F
A
E
N
P
K
A
G
D
E
F
V
E
K
T
L
S
T
I
A
T
S
T
D
A
A
S
V
-
V
H
S
T
D
L
V
V
E
A
I
V
E
N
L
K
V
K
N
E
L
F
K
R
L
D
K
F
A
A
E
H
T
I
F
A
S
N
T
A
S
L
Q
I
T
S
I
A
N
A
T
T
R
Q
D
R
F
A
G
L
H
F
F
N
P
V
P
V
M
K
L
V
E
V
I
K
T
P
M
T
S
Q
K
T
F
E
S
L
V
D
F
S
K
A
L
G
K
H
P
V
S
C
-
K
D
T
P
G
F
I
V
N
R
L
L
V
P
Y
L
M
E
A
I
R
L
Y
E
R
G
D
A
S
K
E
D
I
D
T
A
M
K
L
G
A
G
Y
P
M
G
P
F
E
L
L
D
Y
V
G
L
D
T
T
K
F
I
V
D
G
W
H
E
M
D
A
E
N
P
L--
H
Q
P
S
P
S
L
N
K
L
V
A
E
N
K
F
G
K
K
T
G
E
G
F
Y
K
Y
K
----
13
PsiBlast_PDB
66.76
41%
-9
- C2 -
1IL0
3
HCDH_HUMAN
A:
[15-302]
--
V
K
H
V
T
V
I
G
G
G
L
M
G
A
G
I
A
Q
V
A
A
A
T
G
H
T
V
V
L
V
D
Q
T
E
D
I
L
A
K
S
K
K
G
I
E
E
S
L
R
K
V
A
-
K
K
K
F
A
E
N
P
K
A
G
D
E
F
V
E
K
T
L
S
T
I
A
T
S
T
D
A
A
S
V
-
V
H
S
T
D
L
V
V
E
A
I
V
E
N
L
K
V
K
N
E
L
F
K
R
L
D
K
F
A
A
E
H
T
I
F
A
S
N
T
S
S
L
Q
I
T
S
I
A
N
A
T
T
R
Q
D
R
F
A
G
L
H
F
F
N
P
V
P
V
M
K
L
V
Q
V
I
K
T
P
M
T
S
Q
K
T
F
E
S
L
V
D
F
S
K
A
L
G
K
H
P
V
S
C
-
K
D
T
P
G
F
I
V
N
R
L
L
V
P
Y
L
M
E
A
I
R
L
Y
E
R
G
D
A
S
K
E
D
I
D
T
A
M
K
L
G
A
G
Y
P
M
G
P
F
E
L
L
D
Y
V
G
L
D
T
T
K
F
I
V
D
G
W
H
E
M
D
A
E
N
P
L--
H
Q
P
S
P
S
L
N
K
L
V
A
E
N
K
F
G
K
K
T
G
E
G
F
Y
K
Y
K
----
51
PsiBlast_CBE
66.47
41%
-13
- C2 -
1LSJ
1
HCDH_HUMAN
B:
[15-302]
--
V
K
H
V
T
V
I
G
G
G
L
M
G
A
G
I
A
Q
V
A
A
A
T
G
H
T
V
V
L
V
D
Q
T
E
D
ILA
K
S
K
K
G
I
E
E
S
L
R
K
V
A
-
K
K
KF
A
E
N
P
K
A
G
D
E
F
V
E
K
T
L
S
T
I
A
T
S
T
D
A
A
S
V
-
V
H
S
T
D
L
V
V
E
A
I
V
Q
N
L
K
V
K
N
E
L
F
K
R
L
D
K
F
A
A
E
H
T
I
F
A
S
N
T
S
S
L
Q
I
T
S
I
A
N
A
T
T
R
Q
D
R
F
A
G
L
H
F
F
N
P
V
P
V
M
K
L
V
E
V
I
K
T
P
M
T
S
Q
K
T
F
E
S
L
V
D
F
S
K
A
L
G
K
H
P
V
S
C
-
K
D
T
P
G
F
I
V
N
R
L
L
V
P
Y
L
M
E
A
I
R
L
Y
E
R
G
D
A
S
K
E
D
I
D
T
A
M
K
L
G
A
G
Y
P
M
G
P
F
E
L
L
D
Y
V
G
L
D
T
T
K
F
I
V
D
G
W
H
E
M
D
A
E
N
P
L--
H
Q
P
S
P
S
L
N
K
L
V
A
E
N
K
F
G
K
K
T
G
E
G
F
Y
K
Y
K
----
52
PsiBlast_CBE
66.34
41%
-8
- C2 -
1IL0
3
HCDH_HUMAN
B:
[15-302]
--
V
K
H
V
T
V
I
G
G
G
L
M
G
A
G
I
A
Q
V
A
A
A
T
G
H
T
V
V
L
V
D
Q
T
E
D
ILA
K
S
K
K
G
I
E
E
S
L
R
K
V
A
-
K
K
KF
A
E
N
P
K
A
G
D
E
F
V
E
K
T
L
S
T
I
A
T
S
T
D
A
A
S
V
-
V
H
S
T
D
L
V
V
E
A
I
V
E
N
L
K
V
K
N
E
L
F
K
R
L
D
K
F
A
A
E
H
T
I
F
A
S
N
T
S
S
L
Q
I
T
S
I
A
N
A
T
T
R
Q
D
R
F
A
G
L
H
F
F
N
P
V
P
V
M
K
L
V
Q
V
I
K
T
P
M
T
S
Q
K
T
F
E
S
L
V
D
F
S
K
A
L
G
K
H
P
V
S
C
-
K
D
T
P
G
F
I
V
N
R
L
L
V
P
Y
L
M
E
A
I
R
L
Y
E
R
G
D
A
S
K
E
D
I
D
T
A
M
K
L
G
A
G
Y
P
M
G
P
F
E
L
L
D
Y
V
G
L
D
T
T
K
F
I
V
D
G
W
H
E
M
D
A
E
N
P
L--
H
Q
P
S
P
S
L
N
K
L
V
A
E
N
K
F
G
K
K
T
G
E
G
F
Y
K
Y
K
----
56
PsiBlast_CBE
66.21
41%
-8
- C2 -
1M75
3
HCDH_HUMAN
B:
[15-302]
--
V
K
H
V
T
V
I
G
G
G
L
M
G
A
G
I
A
Q
V
A
A
A
T
G
H
T
V
V
L
V
D
Q
T
E
D
ILA
K
S
K
K
G
I
E
E
S
L
R
K
V
A
-
K
K
KF
A
E
N
P
K
A
G
D
E
F
V
E
K
T
L
S
T
I
A
T
S
T
D
A
A
S
V
-
V
H
S
T
D
L
V
V
E
A
I
V
E
N
L
K
V
K
N
E
L
F
K
R
L
D
K
F
A
A
E
H
T
I
F
A
S
N
T
S
S
L
Q
I
T
S
I
A
N
A
T
T
R
Q
D
R
F
A
G
L
H
F
F
N
P
V
P
V
M
K
L
V
E
V
I
K
T
P
M
T
S
Q
K
T
F
E
S
L
V
D
F
S
K
A
L
G
K
H
P
V
S
C
-
K
D
T
P
G
F
I
V
S
R
L
L
V
P
Y
L
M
E
A
I
R
L
Y
E
R
G
D
A
S
K
E
D
I
D
T
A
M
K
L
G
A
G
Y
P
M
G
P
F
E
L
L
D
Y
V
G
L
D
T
T
K
F
I
V
D
G
W
H
E
M
D
A
E
N
P
L--
H
Q
P
S
P
S
L
N
K
L
V
A
E
N
K
F
G
K
K
T
G
E
G
F
Y
K
Y
K
----
54
PsiBlast_CBE
65.93
41%
-12
- C2 -
3HAD
1
HCDH_HUMAN
B:
[15-302]
--
V
K
H
V
T
V
I
G
G
G
L
M
G
A
G
I
A
Q
V
A
A
A
T
G
H
T
V
V
L
V
D
Q
T
E
D
ILA
K
S
K
K
G
I
E
E
S
L
R
K
V
A
-
K
K
KF
A
E
N
P
K
A
G
D
E
F
V
E
K
T
L
S
T
I
A
T
S
T
D
A
A
S
V
-
V
H
S
T
D
L
V
V
E
A
I
V
E
N
L
K
V
K
N
E
L
F
K
R
L
D
K
R
A
A
E
H
T
I
F
A
S
N
T
S
S
L
Q
I
T
S
I
A
N
A
T
T
R
Q
D
R
F
A
G
L
H
F
F
N
P
V
P
V
M
K
L
V
E
V
I
K
T
P
M
T
S
Q
K
T
F
E
S
L
V
D
F
S
K
A
L
G
K
H
P
V
S
C
-
K
D
T
P
G
F
I
V
N
R
L
L
V
P
Y
L
M
E
A
I
R
L
Y
E
R
G
D
A
S
K
E
D
I
D
T
A
M
K
L
G
A
G
Y
P
M
G
P
F
E
L
L
D
Y
V
G
L
D
T
T
K
F
I
V
D
G
W
H
E
M
D
A
E
N
P
L--
H
Q
P
S
P
S
L
N
K
L
V
A
E
N
K
F
G
K
K
T
G
E
G
F
Y
K
Y
K
----
18
PsiBlast_PDB
65.81
41%
-11
- C2 -
1M75
3
HCDH_HUMAN
A:
[15-302]
--
V
K
H
V
T
V
I
G
G
G
L
M
G
A
G
I
A
Q
V
A
A
A
T
G
H
T
V
V
L
V
D
Q
T
E
D
I
L
A
K
S
K
K
G
I
E
E
S
L
R
K
V
A
-
K
K
KF
A
E
N
P
K
A
G
D
E
F
V
E
K
T
L
S
T
I
A
T
S
T
D
A
A
S
V
-
V
H
S
T
D
L
V
V
E
A
I
V
E
N
L
K
V
K
N
E
L
F
K
R
L
D
K
F
A
A
E
H
T
I
F
A
S
N
T
S
S
L
Q
I
T
S
I
A
N
A
T
T
R
Q
D
R
F
A
G
L
H
F
F
N
P
V
P
V
M
K
L
V
E
V
I
K
T
P
M
T
S
Q
K
T
F
E
S
L
V
D
F
S
K
A
L
G
K
H
P
V
S
C
-
K
D
T
P
G
F
I
V
S
R
L
L
V
P
Y
L
M
E
A
I
R
L
Y
E
R
G
D
A
S
K
E
D
I
D
T
A
M
K
L
G
A
G
Y
P
M
G
P
F
E
L
L
D
Y
V
G
L
D
T
T
K
F
I
V
D
G
W
H
E
M
D
A
E
N
P
L--
H
Q
P
S
P
S
L
N
K
L
V
A
E
N
K
F
G
K
K
T
G
E
G
F
Y
K
Y
K
----
47
PsiBlast_CBE
65.65
41%
-8
- C2 -
1F0Y
3
HCDH_HUMAN
B:
[15-302]
--
V
K
H
V
T
V
I
G
G
G
L
M
G
A
G
I
A
Q
V
A
A
A
T
G
H
T
V
V
L
V
D
Q
T
E
D
ILA
K
S
K
K
G
I
E
E
S
L
R
K
V
A
-
K
K
KF
A
E
N
P
K
A
G
D
E
F
V
E
K
T
L
S
T
I
A
T
S
T
D
A
A
S
V
-
V
H
S
T
D
L
V
V
E
A
I
V
E
N
L
K
V
K
N
E
L
F
K
R
L
D
K
F
A
A
E
H
T
I
F
A
S
N
T
S
S
L
Q
I
T
S
I
A
N
A
T
T
R
Q
D
R
F
A
G
L
H
F
F
N
P
V
P
V
M
K
L
V
E
V
I
K
T
P
M
T
S
Q
K
T
F
E
S
L
V
D
F
S
K
A
L
G
K
H
P
V
S
C
-
K
D
T
P
G
F
I
V
N
R
L
L
V
P
Y
L
M
E
A
I
R
L
Y
E
R
G
D
A
S
K
E
D
I
D
T
A
M
K
L
G
A
G
Y
P
M
G
P
F
E
L
L
D
Y
V
G
L
D
T
T
K
F
I
V
D
G
W
H
E
M
D
A
E
N
P
L--
H
Q
P
S
P
S
L
N
K
L
V
A
E
N
K
F
G
K
K
T
G
E
G
F
Y
K
Y
K
----
14
PsiBlast_PDB
65.29
41%
-15
- C2 -
1LSJ
1
HCDH_HUMAN
A:
[15-302]
--
V
K
H
V
T
V
I
G
G
G
L
M
G
A
G
I
A
Q
V
A
A
A
T
G
H
T
V
V
L
V
D
Q
T
E
D
I
L
A
K
S
K
K
G
I
E
E
S
L
R
K
V
A
-
K
K
K
F
A
E
N
P
K
A
G
D
E
F
V
E
K
T
L
S
T
I
A
T
S
T
D
A
A
S
V
-
V
H
S
T
D
L
V
V
E
A
I
V
Q
N
L
K
V
K
N
E
L
F
K
R
L
D
K
F
A
A
E
H
T
I
F
A
S
N
T
S
S
L
Q
I
T
S
I
A
N
A
T
T
R
Q
D
R
F
A
G
L
H
F
F
N
P
V
P
V
M
K
L
V
E
V
I
K
T
P
M
T
S
Q
K
T
F
E
S
L
V
D
F
S
K
A
L
G
K
H
P
V
S
C
-
K
D
T
P
G
F
I
V
N
R
L
L
V
P
Y
L
M
E
A
I
R
L
Y
E
R
G
D
A
S
K
E
D
I
D
T
A
M
K
L
G
A
G
Y
P
M
G
P
F
E
L
L
D
Y
V
G
L
D
T
T
K
F
I
V
D
G
W
H
E
M
D
A
E
N
P
L--
H
Q
P
S
P
S
L
N
K
L
V
A
E
N
K
F
G
K
K
T
G
E
G
F
Y
K
Y
K
----
12
PsiBlast_PDB
64.52
40%
-6
- C2 -
3HDH
1
HCDH_PIG
A:
[15-302]
--
V
K
H
V
T
V
I
G
G
G
L
M
G
A
G
I
A
Q
V
A
A
A
T
G
H
T
V
V
L
V
D
Q
T
E
D
I
L
A
K
S
K
K
G
I
E
E
S
L
R
K
V
A
-
K
K
K
F
A
E
N
P
K
A
G
D
E
F
V
E
K
T
L
S
S
I
S
T
S
T
D
A
A
S
V
-
V
H
S
T
D
L
V
V
E
A
I
V
E
N
L
K
V
K
S
E
L
F
K
R
L
D
K
F
A
A
E
H
T
I
F
A
S
N
T
S
S
L
Q
I
T
S
L
A
N
A
T
T
R
Q
D
R
F
A
G
L
H
F
F
N
P
V
P
L
M
K
L
V
E
V
V
K
T
P
M
T
S
Q
K
T
L
E
S
L
V
D
F
S
K
T
L
G
K
H
P
V
S
C
-
K
D
T
P
G
F
I
V
N
R
L
L
V
P
Y
L
I
E
A
V
R
L
Y
E
R
G
D
A
S
K
E
D
I
D
T
A
M
K
L
G
A
G
Y
P
M
G
P
F
E
L
L
D
Y
V
G
L
D
T
T
K
F
I
I
D
G
W
H
E
--
M
D
S
Q
NPL
F
Q
P
S
P
A
M
N
K
L
V
A
E
N
K
F
G
K
K
T
G
E
G
F
Y
K
Y
K
----
50
PsiBlast_CBE
64.36
40%
-8
- C2 -
3HDH
1
HCDH_PIG
B:
[15-302]
--
V
K
H
V
T
V
I
G
G
G
L
M
G
A
G
I
A
Q
V
A
A
A
T
G
H
T
V
V
L
V
D
Q
T
E
D
ILA
K
S
K
K
G
I
E
E
S
L
R
K
V
A
-
K
K
KF
A
E
N
P
K
A
G
D
E
F
V
E
K
T
L
S
S
I
S
T
S
T
D
A
A
S
V
-
V
H
S
T
D
L
V
V
E
A
I
V
E
N
L
K
V
K
S
E
L
F
K
R
L
D
K
F
A
A
E
H
T
I
F
A
S
N
T
S
S
L
Q
I
T
S
L
A
N
A
T
T
R
Q
D
R
F
A
G
L
H
F
F
N
P
V
P
L
M
K
L
V
E
V
V
K
T
P
M
T
S
Q
K
T
L
E
S
L
V
D
F
S
K
T
L
G
K
H
P
V
S
C
-
K
D
T
P
G
F
I
V
N
R
L
L
V
P
Y
L
I
E
A
V
R
L
Y
E
R
G
D
A
S
K
E
D
I
D
T
A
M
K
L
G
A
G
Y
P
M
G
P
F
E
L
L
D
Y
V
G
L
D
T
T
K
F
I
I
D
G
W
H
E
--
M
D
S
Q
NPL
F
Q
P
S
P
A
M
N
K
L
V
A
E
N
K
F
G
K
K
T
G
E
G
F
Y
K
Y
K
----
53
PsiBlast_CBE
64.05
41%
-19
- C2 -
1LSO
1
HCDH_HUMAN
B:
[15-302]
--
V
K
H
V
T
V
I
G
G
G
L
M
G
A
G
I
A
Q
V
A
A
A
T
G
H
T
V
V
L
V
D
Q
T
E
D
ILA
K
S
K
K
G
I
E
E
S
L
R
K
V
A
-
K
K
KF
A
E
N
P
K
A
G
D
E
F
V
E
K
T
L
S
T
I
A
T
S
T
D
A
A
S
V
-
V
H
S
T
D
L
V
V
E
A
I
V
E
N
L
K
V
K
N
E
L
F
K
R
L
D
K
F
A
A
E
H
T
I
F
A
S
N
T
A
S
L
Q
I
T
S
I
A
N
A
T
T
R
Q
D
R
F
A
G
L
H
F
F
N
P
V
P
V
M
K
L
V
E
V
I
K
T
P
M
T
S
Q
K
T
F
E
S
L
V
D
F
S
K
A
L
G
K
H
P
V
S
C
-
K
D
T
P
G
F
I
V
N
R
L
L
V
P
Y
L
M
E
A
I
R
L
Y
E
R
G
D
A
S
K
E
D
I
D
T
A
M
K
L
G
A
G
Y
P
M
G
P
F
E
L
L
D
Y
V
G
L
D
T
T
K
F
I
V
D
G
W
H
E
M
D
A
E
N
P
L--
H
Q
P
S
P
S
L
N
K
L
V
A
E
N
K
F
G
K
K
T
G
E
G
F
Y
K
Y
K
----
86
PsiBlast_CBE
62.17
31%
-20
- C2 -
4E13
7
?
A:
[4-283]
--
I
T
N
V
T
V
L
G
T
G
V
L
G
S
Q
I
A
F
Q
T
A
F
H
G
F
A
V
T
A
Y
D
I
N
T
D
---
A
L
D
A
A
K
K
R
F
E
G
L
A
A
V
Y
E
--
K
E
V
A
G
A
A
D
G
A
A
Q
K
A
L
G
G
I
R
Y
S
D
D
L
A
Q
A
V
K
D
A
-
D
L
V
I
E
A
V
P
E
S
L
D
L
K
R
D
I
Y
T
K
L
G
E
L
A
P
A
K
T
I
F
A
T
N
S
S
T
L
L
P
S
D
L
V
G
Y
T
G
R
G
D
K
F
L
A
L
H
F
A
N
H
V
W
V
N
N
T
A
E
V
M
G
T
T
K
T
D
P
E
V
Y
Q
Q
V
V
E
F
A
S
A
I
G
M
V
P
I
E
L
K
K
E
K
A
G
Y
V
L
N
S
L
L
V
P
L
L
D
A
A
A
E
L
L
V
D
G
I
A
D
P
E
T
I
D
K
T
W
R
I
G
T
G
A
P
K
G
P
F
E
I
F
D
I
V
G
L
T
T
A
Y
N
I
S
S
V
--
S
G
P
K
Q
R
E
---
F
-
A
A
Y
L
K
E
N
Y
I
D
K
G
K
L
G
L
A
T
G
E
G
F
Y
R
Y
-----